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https://www.readbyqxmd.com/read/28207167/bisap-ranson-lactate-and-others-biomarkers-in-prediction-of-severe-acute-pancreatitis-in-a-european-cohort
#1
Francisco Valverde-López, Ana M Matas-Cobos, Carlos Alegría-Motte, Rita Jiménez-Rosales, Margarita Úbeda-Muñoz, Eduardo Redondo-Cerezo
BACKGROUND AND AIM: Assessing and comparing the predicting ability of some scores and biomarkers in Acute Pancreatitis (AP). METHODS: We prospectively collected data from 269 patients diagnosed of AP, admitted to Virgen de las Nieves University Hospital between June 2010 and June 2012. Blood urea nitrogen (BUN), C-reactive protein (CRP) and creatinine (Cr) were measured on admission and after 48 hours, lactate and BISAP only on admission and RANSON within the first 48 hours...
February 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28181127/role-of-bedside-pancreatic-scores-and-c-reactive-protein-in-predicting-pancreatic-fluid-collections-and-necrosis
#2
Doraiswami Babu Vinish, Vishnu Abishek, K Sujatha, S Arulprakash, Rajkumar Solomon, P Ganesh
BACKGROUND: Acute pancreatitis is a disease with variable outcome; the course of the disease can be modified by early aggressive management in patients with severe pancreatitis. Easily calculable pancreatic scores and investigations can help to triage these patients. We aimed to determine the role of bedside index for severity in acute pancreatitis (BISAP), harmless acute pancreatitis score (HAPS), and systemic inflammatory response syndrome (SIRS) scores on day of admission and C-reactive protein (CRP) at 48 h for predicting the presence of pancreatic fluid collection (PFC) and necrosis on CT scans done at 72 h...
February 9, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28164588/elevated-presepsin-levels-are-associated-with-severity-and-prognosis-of-severe-acute-pancreatitis
#3
Jianbo Lin, Zhe Li, Yanhong Zheng, Yang Zhang, Cunhua Shao, Gongpan Liu, Jiangong Li
BACKGROUND: Current clinical scoring systems are insufficient in the early identification of severe acute pancreatitis (SAP) patients at risk of developing potentially lethal complications. This present study was designed to evaluate the relationship of presepsin with disease severity, local complications, organ failure, and mortality of SAP. METHODS: Eighty-five SAP patients and 85 gender- and age-matched healthy volunteers were enrolled. Presepsin concentrations were measured on admission from SAP patients and at study entry from healthy individuals...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28125855/predictors-and-outcomes-of-acute-pancreatitis-in-critically-ill-patients-presenting-to-the-emergency-department-of-a-tertiary-referral-centre-in-australia
#4
Krishnaswamy Sundararajan, Tom Schoeman, Lara Hughes, Suzanne Edwards, Benjamin Reddi
OBJECTIVE: To provide a current review of the clinical characteristics, predictors and outcomes in critically ill patients presenting to the ED with acute pancreatitis and subsequently admitted to an intensive care unit (ICU) of a tertiary referral centre in Australia. METHODS: A retrospective single-centre study of adult patients admitted with pancreatitis. Severe acute pancreatitis defined by Bedside Index of Severity in Acute Pancreatitis (BISAP) score ≥2. RESULTS: Eighty-seven patients fulfilled criteria for inclusion during the study period, representing 0...
January 26, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28013317/determination-of-serum-neutrophil-gelatinase-associated-lipocalin-at-the-early-stage-of-acute-pancreatitis
#5
Mateusz Sporek, Paulina Dumnicka, Agnieszka Gala-Błądzińska, Małgorzata Mazur-Laskowska, Jerzy Walocha, Piotr Ceranowicz, Zygmunt Warzecha, Artur Dembiński, Marek Kuźniewski, Rafał Olszanecki, Beata Kuśnierz-Cabala
AIM: e aim of the study was to assess the diagnostic value of serum concentrations of neutrophil gelatinase-associated lipocalin (sNGAL) for the determination of the severity of acute pancreatitis (AP) at the early stage of the disease. MATERIALS AND METHOD: The study group consisted of 65 patients(34 men and 31 women),aged 62.2 ± 16.0, admitted to the Surgery Department of the District Hospital in Sucha Beskidzka, Poland, with the diagnosis of AP according to the revised Atlanta classification (2012)...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28007685/early-prediction-of-organ-failure-under-the-revised-atlanta-classification
#6
Jian Liu, Feng Cao, Xiao Min Dong, Peng Yu Li, Hai Chao Li, Bao Ju Qi, Fei Li
BACKGROUND/AIMS: This study aimed to compare the ability of conventional laboratory markers and scoring systems to early predict organ failure (OF) and to differentiate between transient and persistent OF in patients with acute pancreatitis (AP) using the revised Atlanta classification. MATERIALS AND METHODS: We retrospectively analyzed the medical records of 214 patients with AP between January 2014 and July 2015. The predictive values of laboratory markers were analyzed...
January 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27929426/serum-soluble-fms-like-tyrosine-kinase-1-sflt-1-predicts-the-severity-of-acute-pancreatitis
#7
Paulina Dumnicka, Mateusz Sporek, Małgorzata Mazur-Laskowska, Piotr Ceranowicz, Marek Kuźniewski, Ryszard Drożdż, Tadeusz Ambroży, Rafał Olszanecki, Beata Kuśnierz-Cabala
Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27914940/soluble-urokinase-type-plasminogen-activator-receptor-supar-in-patients-with-acute-pancreatitis-ap-progress-in-prediction-of-ap-severity
#8
Michal Lipinski, Alicja Rydzewska-Rosolowska, Andrzej Rydzewski, Malgorzata Cicha, Grazyna Rydzewska
BACKGROUND: Soluble urokinase-type plasminogen activator receptor (suPAR) is a glycoprotein secreted during inflammation and infections. Moreover, increased levels of suPAR are observed after hypoxia and ischaemia. The aim of the study was to assess whether suPAR could represent a useful marker of acute pancreatitis (AP) severity. PATIENTS AND METHODS: We have observed a cohort of 126 prospectively enrolled patients. Based on the presence of persistent organ failure (more than 48 h) and local complications (diagnosis of moderate AP [MSAP]), patients were classified into three groups: mild AP (MAP), moderate and severe AP (SAP)...
November 25, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27882045/comparison-of-bisap-ranson-mctsi-and-apache-ii-in-predicting-severity-and-prognoses-of-hyperlipidemic-acute-pancreatitis-in-chinese-patients
#9
Lixin Yang, Jing Liu, Yun Xing, Lichuan Du, Jing Chen, Xin Liu, Jianyu Hao
In recent years, with the developing of living standard, hyperlipidemia becomes the second major reason of acute pancreatitis. It is important to predict the severity and prognosis at early stage of hyperlipidemic acute pancreatitis (HLAP). We compared the BISAP, Ranson, MCTSI, and APACHE II scoring system in predicting MSAP and SAP, local complications, and mortality of HLAP. A total of 326 diagnosed hyperlipidemic acute pancreatitis patients from August 2006 to July 2015 were studied retrospectively. Our result showed that all four scoring systems can be used to predict the severity, local complications, and mortality of HLAP...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27586977/-the-role-of-four-criteria-in-assessment-of-the-severity-and-prognosis-of-hyperlipidemic-acute-pancreatitis
#10
L X Yang, L C Du, X Liu, J Chen, J Y Hao
OBJECTIVE: To explore the four criteria, including bedside index for severity in acute pancreatitis(BISAP), Ranson score, modified CT severity index(MCTSI) and acute physiology and chronic health evaluation scoring systemⅡ(APACHE Ⅱ) in assessment of severity and prognosis of hyperlipidemic acute pancreatitis. METHODS: A total of 326 patients with hyperlipidemic acute pancreatitis were studied retrospectively from August 2006 to July 2015. The discrepancy of the four criteria in assessment of severity and prognosis of hyperlipidemic acute pancreatitis was compared with chi-square test and receiver operating characteristic curve...
September 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27513835/urine-ngal-is-useful-in-the-clinical-evaluation-of-renal-function-in-the-early-course-of-acute-pancreatitis
#11
Mateusz Sporek, Agnieszka Gala-Błądzińska, Paulina Dumnicka, Małgorzata Mazur-Laskowska, Stanislas Kielczewski, Jerzy Walocha, Piotr Ceranowicz, Marek Kuźniewski, Jerzy Mituś, Beata Kuśnierz-Cabala
INTRODUCTION: Acute Kidney Injury (AKI) is a serious early complications in patients with acute pancreatitis (AP) that signifcantly increases mortality rates compared to patients without AKI. The early diagnosis of AKI during its treatable phases and implementation of appropriate treatment protocols can improve outcomes for this group of patients. A promising biomarker for AKI is neutrophil gelatinase-associated lipocalin (NGAL). AIM: This study evaluated the diagnostic value of NGAL concentrations in serum and in urine for patients developing AKI as an early complication of AP compared to AP patients without AKI...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/27459482/-early-diagnosis-of-mild-acute-pancreatitis
#12
A V Popov, D A Mineev, A I Ershova, N N Popova
AIM: to analyze the efficacy of early detection of patients with mild acute pancreatitis. MATERIAL AND METHODS: 61 patients with acute pancreatitis who do not require intensive care were analyzed. Severity of condition was assessed using integral scales, i.e. modified index of severe pancreatitis severity (MITOP), BISAP, HAPS, SOFA, SIRS, CTSI and Atlanta classification (2012). RESULTS: Verification of mild course of disease according to MITOP scores ≤0...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27148850/stereotypical-metabolic-response-to-endoscopic-retrograde-cholangiopancreatography-show-alterations-in-pancreatic-function-regardless-of-post-procedure-pancreatitis
#13
Elizabeth R Lusczek, Kristen Colling, Sydne Muratore, Darwin Conwell, Martin Freeman, Greg Beilman
OBJECTIVES: Metabolomics-based diagnosis or prediction of risk may improve patient outcomes and improve understanding of the pathogenesis of acute pancreatitis (AP). Endoscopic retrograde cholangiopancreatography (ERCP) is a risk factor for developing AP. This pilot study examined metabolomes of patients before and after ERCP, hypothesizing that metabolomics could differentiate between patients who did and did not develop post-ERCP pancreatitis, and that biomarkers associated with development of AP could be identified...
May 5, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27042605/differences-in-severity-and-outcomes-between-hypertriglyceridemia-and-alcohol-induced-pancreatitis
#14
Hemant Goyal, Betsy Smith, Chelsey Bayer, Carla Rutherford, Danielle Shelnut
BACKGROUND: Alcohol and hypertriglyceridemia (HTG) are among the most common causes of acute pancreatitis (AP) after gallstones. However, differences in severity at the time of presentation and outcomes have not been well-studied. OBJECTIVE: The aim of this study is to assess the differences between severity at presentation and outcomes of AP of hypertriglyceridemic and alcoholic origins. MATERIALS AND METHODS: A retrospective review of 177 patients who were discharged with diagnosis of AP was performed...
February 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/26613249/evaluating-the-ability-of-the-bedside-index-for-severity-of-acute-pancreatitis-score-to-predict-severe-acute-pancreatitis-a-meta-analysis
#15
Yu-Xia Yang, Li Li
OBJECTIVE: To evaluate the diagnostic performance of the bedside index for severity in acute pancreatitis (BISAP) score in predicting severe acute pancreatitis (SAP). MATERIALS AND METHODS: A systematic search was conducted using PubMed, Cochrane library and EMBASE databases up to May 2014, and 9 related studies, including 1,972 subjects, were reviewed. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnosis of odds ratio (DOR) and hierarchic summary receiver-operating characteristic (HSROC) curves, as well as the area under the HSROC curve (AUC), were assessed using the HSROC and bivariate mixed effects models...
2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/26513663/correction-the-value-of-bisap-score-for-predicting-mortality-and-severity-in-acute-pancreatitis-a-systematic-review-and-meta-analysis
#16
Wei Gao, Hong-Xia Yang, Cheng-En Ma
No abstract text is available yet for this article.
2015: PloS One
https://www.readbyqxmd.com/read/26201934/naso-jejunal-fluid-resuscitation-in-predicted-severe-acute-pancreatitis-randomized-comparative-study-with-intravenous-ringer-s-lactate
#17
RANDOMIZED CONTROLLED TRIAL
Vishal Sharma, Surinder S Rana, Ravi Sharma, Vinita Chaudhary, Rajesh Gupta, Deepak K Bhasin
INTRODUCTION: Early management of severe acute pancreatitis (SAP) includes intravenous fluid resuscitation. AIM: To confirm feasibility of naso-jejunal (NJ) fluid resuscitation using oral hydration solution (ORS) and compare its efficacy with intravenous (IV) fluid resuscitation using Ringer Lactate (RL) in predicted SAP. PATIENTS AND METHODS: All patients of predicted SAP (presence of SIRS or BISAP > 2) without significant co morbidities were randomized to NJ group (ORS: 20 ml/kg bolus and then 3 mL/kg/h) or IV group (RL infusion at same rate)...
January 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26129965/a-study-of-radiological-scoring-system-evaluating-extrapancreatic-inflammation-with-conventional-radiological-and-clinical-scores-in-predicting-outcomes-in-acute-pancreatitis
#18
Vishal Sharma, Surinder S Rana, Ravi K Sharma, Mandeep Kang, Rajesh Gupta, Deepak K Bhasin
BACKGROUND: A number of scoring systems are available to predict prognosis in acute pancreatitis (AP). The aim of the study was to compare extra-pancreatic inflammation on computed tomography (CT) (EPIC score) and renal rim sign with clinical scores (BISAP, SIRS) and conventional CT severity index (CTSI) and modified CTSI (MCTSI) in predicting persistent organ failure (POF), intervention and mortality. METHODS: The demographic, clinical and radiographic data from patients with AP were retrospectively evaluated...
July 2015: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/26126430/a-study-of-radiological-scoring-system-evaluating-extrapancreatic-inflammation-with-conventional-radiological-and-clinical-scores-in-predicting-outcomes-in-acute-pancreatitis
#19
Vishal Sharma, Surinder S Rana, Ravi K Sharma, Mandeep Kang, Rajesh Gupta, Deepak K Bhasin
BACKGROUND: A number of scoring systems are available to predict prognosis in acute pancreatitis (AP). The aim of the study was to compare extra-pancreatic inflammation on computed tomography (CT) (EPIC score) and renal rim sign with clinical scores (BISAP, SIRS) and conventional CT severity index (CTSI) and modified CTSI (MCTSI) in predicting persistent organ failure (POF), intervention and mortality. METHODS: The demographic, clinical and radiographic data from patients with AP were retrospectively evaluated...
July 2015: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/26091293/the-value-of-bisap-score-for-predicting-mortality-and-severity-in-acute-pancreatitis-a-systematic-review-and-meta-analysis
#20
REVIEW
Wei Gao, Hong-Xia Yang, Cheng-En Ma
PURPOSE: The Bedside Index for Severity in Acute Pancreatitis (BISAP) score has been developed to identify patients at high risk for mortality or severe disease early during the course of acute pancreatitis. We aimed to undertake a meta-analysis to quantify the accuracy of BISAP score for predicting mortality and severe acute pancreatitis (SAP). MATERIALS AND METHODS: We searched the databases of Pubmed, Embase, and the Cochrane Library to identify studies using the BISAP score to predict mortality or SAP...
2015: PloS One
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