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https://www.readbyqxmd.com/read/29106852/postoperative-objective-detecting-techniques-for-cochlear-implant-children-with-inner-ear-malformation
#1
Xiao-Feng Qiao, Xin Li, Qiang-Wei Zhang, Tong-Li Li, Dong Wang
OBJECTIVES: This study aims to investigate the changing characteristics and rules of electrically-evoked auditory brainstem response (EABR), electrically-evoked stapedius reflex threshold (ESRT) and neural response telemetry (NRT) after cochlear implant in children with inner ear malformation, and guide postoperative equipment debug. METHODS: A total of 88 children with either normal cochlea (control group) or inner ear malformation (test group) received Australian 24 multi-channel cochlear implants...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29076926/usefulness-of-electrical-auditory-brainstem-responses-to-assess-the-functionality-of-the-cochlear-nerve-using-an-intracochlear-test-electrode
#2
Luis Lassaletta, Marek Polak, Jan Huesers, Miguel Díaz-Gómez, Miryam Calvino, Isabel Varela-Nieto, Javier Gavilán
OBJECTIVE: To use an intracochlear test electrode to assess the integrity and the functionality of the auditory nerve in cochlear implant (CI) recipients and to compare electrical auditory brainstem responses (eABR) via the test electrode with the eABR responses with the CI. SETTING: Otolaryngology department, tertiary referral hospital. PATIENTS: Ten subjects (age at implantation 55 yr, range, 19-72) were subsequently implanted with a MED-EL CONCERTO CI on the side without any useful residual hearing...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28964288/the-value-of-intraoperative-eabrs-in-auditory-brainstem-implantation
#3
Abbas Anwar, Alison Singleton, Yixin Fang, Binhuan Wang, William Shapiro, J Thomas Roland, Susan B Waltzman
OBJECTIVE: To compare the intraoperative electrically evoked auditory brainstem response (EABR) morphologies between neurofibromatosis II (NF2) adult auditory brainstem implant (ABI) recipients who had auditory percepts post-operatively and those who did not and between NF2 adult ABI recipients and non-NF2 pediatric ABI recipients. METHODS: This was a retrospective case series at a single tertiary academic referral center examining all ABI recipients from 1994 to 2016, which included 34 NF2 adults and 11 non-NF2 children...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28859106/local-inner-ear-application-of-dexamethasone-in-cochlear-implant-models-is-safe-for-auditory-neurons-and-increases-the-neuroprotective-effect-of-chronic-electrical-stimulation
#4
Verena Scheper, Roland Hessler, Mareike Hütten, Maciej Wilk, Claude Jolly, Thomas Lenarz, Gerrit Paasche
Dexamethasone (DEX) can reduce fibrous tissue growth as well as loss of residual hearing which may occur after cochlear implantation. Little is known about the effect of local inner ear DEX treatment on the spiral ganglion neurons (SGN), which are the target of the electrical stimulation with a cochlear implant (CI). Three different clinically relevant strategies of DEX-delivery into the inner ear were used. DEX was either eluted from the electrode carriers' silicone, released from a reservoir by passive diffusion, or actively applied using a pump based system...
2017: PloS One
https://www.readbyqxmd.com/read/28812341/efficient-sky-blue-perovskite-light-emitting-devices-based-on-ethylammonium-bromide-induced-layered-perovskites
#5
Qi Wang, Jie Ren, Xue-Feng Peng, Xia-Xia Ji, Xiao-Hui Yang
Low-dimensional organometallic halide perovskites are actively studied for the light-emitting applications due to their properties such as solution processability, high luminescence quantum yield, large exciton binding energy, and tunable band gap. Introduction of large-group ammonium halides not only serves as a convenient and versatile method to obtain layered perovskites but also allows the exploitation of the energy-funneling process to achieve a high-efficiency light emission. Herein, we investigate the influence of the addition of ethylammonium bromide on the morphology, crystallite structure, and optical properties of the resultant perovskite materials and report that the phase transition from bulk to layered perovskite occurs in the presence of excess ethylammonium bromide...
August 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28776202/neurotrophin-gene-therapy-in-deafened-ears-with-cochlear-implants-long-term-effects-on-nerve-survival-and-functional-measures
#6
Bryan E Pfingst, Deborah J Colesa, Donald L Swiderski, Aaron P Hughes, Stefan B Strahl, Moaz Sinan, Yehoash Raphael
Because cochlear implants function by stimulating the auditory nerve, it is assumed that the condition of the nerve plays an important role in the efficacy of the prosthesis. Thus, considerable research has been devoted to methods of preserving the nerve following deafness. Neurotrophins have been identified as a potential contributor to neural health, but most of the research to date has been done in young animals and for short periods (less than 3 to 6 months) after the onset of treatment. The first objective of the current experiment was to examine the effects of a neurotrophin gene therapy delivery method on spiral ganglion neuron (SGN) preservation and function in the long term (5 to 14 months) in mature guinea pigs with cochlear implants...
August 3, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28634435/the-clinical-uses-of-electrocochleography
#7
REVIEW
William P Gibson
The clinical uses of electrocochleography are reviewed with some technical notes on the apparatus needed to get clear recordings under different conditions. Electrocochleography can be used to estimate auditory thresholds in difficult to test children and a golf club electrode is described. The same electrode can be used to obtain electrical auditory brainstem responses (EABR). Diagnostic testing in the clinic can be performed with a transtympanic needle electrode, and a suitable disposable monopolar electrode is described...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28631161/the-role-of-eabr-with-intracochlear-test-electrode-in-decision-making-between-cochlear-and-brainstem-implants-preliminary-results
#8
Betul Cicek Cinar, Mehmet Yarali, Gamze Atay, Munir Demir Bajin, Gonca Sennaroglu, Levent Sennaroglu
The objective of the study was to discuss the findings of intraoperative electrically evoked auditory brainstem response (eABR) test results with a recently designed intracochlear test electrode (ITE) in terms of their relation to decisions of cochlear or auditory brainstem implantation. This clinical study was conducted in Hacettepe University, Department of Otolaryngology, Head and Neck Surgery and Department of Audiology. Subjects were selected from inner ear malformation (IEM) database. Eleven subjects with profound sensorineural hearing loss were included in the current study with age range from 1 year 3 months to 4 years 3 months for children with prelingual hearing loss...
June 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28607224/evaluation-of-focused-multipolar-stimulation-for-cochlear-implants-a-preclinical-safety-study
#9
Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon
OBJECTIVE: Cochlear implants (CIs) have a limited number of independent stimulation channels due to the highly conductive nature of the fluid-filled cochlea. Attempts to develop highly focused stimulation to improve speech perception in CI users includes the use of simultaneous stimulation via multiple current sources. Focused multipolar (FMP) stimulation is an example of this approach and has been shown to reduce interaction between stimulating channels. However, compared with conventional biphasic current pulses generated from a single current source, FMP is a complex stimulus that includes extended periods of stimulation before charge recovery is achieved, raising questions on whether chronic stimulation with this strategy is safe...
August 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28537687/the-effect-of-optimizing-eabr-parameters-in-artificial-cochlear-implantation-for-auditory-rehabilitation
#10
H-L Yang, Z Liu
OBJECTIVE: The objective of the present study was to observe the relationship between V extraction rate and threshold value of electrically evoked auditory brainstem response (EABR) waves in artificial cochlear implantation, in order to optimize EABR parameters for improving auditory rehabilitation. PATIENTS AND METHODS: Thirty patients without residual hearing and treated with artificial cochlear implants were selected. The experimental group included 17 cases with normal cochlear morphology, four with large vestibular aqueduct syndrome (LVAS), six with Mondini malformation, and three with internal auditory canal stenosis...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28165519/mixing-cations-with-different-alkyl-chain-lengths-markedly-depresses-the-melting-point-in-deep-eutectic-solvents-formed-from-alkylammonium-bromide-salts-and-urea
#11
Zhengfei Chen, Tamar L Greaves, Gregory G Warr, Rob Atkin
The melting point of a deep eutectic solvent formed from a ternary mixture of ethylammonium bromide (EABr), butylammonium bromide (BABr) and urea is 10 °C, which is almost 40 °C lower than the melting points of binary DESs formed from either EABr:urea or BABr:urea mixtures. This reveals a new route to prepare room temperature DESs via mixing different cations.
February 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28121970/resorbable-mesh-cranioplasty-repair-of-bilateral-cerebrospinal-fluid-leaks-following-pediatric-simultaneous-bilateral-auditory-brainstem-implant-surgery
#12
Giacomo Colletti, Marco Mandalà, Vittorio Colletti, Alberto Deganello, Fabiana Allevi, Liliana Colletti
OBJECTIVE: To present a child with cochlear nerve deficiency (CND) who received simultaneous bilateral simultaneous auditory brainstem implants (BS-ABI) and subsequently presented with bilateral cerebrospinal fluid (CSF) leaks unresponsive to standard treatments. To propose a novel rigid retrosigmoid cranioplasty for treating and preventing CSF leaks in children at high risk for this complication. PATIENT: A 3.5-year-old child with CND, vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities, coloboma, heart defect, atresia choanae, retarded growth and development, genital abnormality, and ear abnormality, Arnold Chiari malformation, previous treated tracheo-esophageal fistula underwent BS-ABI...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28079462/establishing-the-standard-method-of-cochlear-implant-in-rongchang-pig
#13
Wei Chen, Haijin Yi, Liang Zhang, Fei Ji, Shuolong Yuan, Yue Zhang, Lili Ren, Jianan Li, Lei Chen, Weiwei Guo, Shiming Yang
CONCLUSIONS: In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic. OBJECTIVE: The aim of this study was to establish a standard method of cochlear implant in a large mammal-pig. METHODS: Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf +/+) and mutation group with hearing loss (Mitf -/-)...
May 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28010677/cochlear-implantation-in-chronic-demyelinating-inflammatory-polyneuropathy
#14
Sarah E Mowry, Sarah King
OBJECTIVE: To describe a case of chronic inflammatory demyelinating polyneuropathy (CDIP) with bilateral sudden sensorineural hearing loss who subsequently benefited from unilateral cochlear implantation. METHODS: case history review and review of the literature for the terms CDIP, hearing loss, cochleovestibular dysfunction, and cochlear implantation. RESULTS: A 49-year-old woman presented with bilateral rapidly progressive sensorineural hearing loss (SNHL) 1 month after an upper respiratory tract infection...
March 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/27938608/-detection-of-the-electric-brain-stem-auditory-response-before-cochlear-implantation-and-its-significance
#15
B Wang, K L Cao, C G Wei, Y Wang, H Li
Objective: Analysis of the outcome of the electric brain stem auditory response (EABR) before cochlear implantation (CI) and the mapping parameters after CI in 187 cases, to explore the significance of EABR before CI. Methods: From February, 2008 to December, 2014, EABR were performed in 187 patients with normal cochlear structures before CI with Nucleus 24R multi-channel cochlear. Including 105 cases of male, 82 cases of female; 152 cases of no residual hearing, 35 cases of residual hearing. Self-design electrical stimulator and US Bio-logic auditory evoked potential were taken, EABR were performed under general anesthesia before CI, recording EABR waveforms, measuring the latency of Ⅱ, Ⅲ, Ⅳ, Ⅴ wave and the Ⅲ-Ⅴ interval, Ⅴ-wave amplitude, Ⅴ-wave threshold and I/O curve slope...
November 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27149268/a-cochlear-implant-performance-prognostic-test-based-on-electrical-field-interactions-evaluated-by-eabr-electrical-auditory-brainstem-responses
#16
Nicolas Guevara, Michel Hoen, Eric Truy, Stéphane Gallego
BACKGROUND: Cochlear implants (CIs) are neural prostheses that have been used routinely in the clinic over the past 25 years. They allow children who were born profoundly deaf, as well as adults affected by hearing loss for whom conventional hearing aids are insufficient, to attain a functional level of hearing. The "modern" CI (i.e., a multi-electrode implant using sequential coding strategies) has yielded good speech comprehension outcomes (recognition level for monosyllabic words about 50% to 60%, and sentence comprehension close to 90%)...
2016: PloS One
https://www.readbyqxmd.com/read/27080646/suitability-of-the-binaural-interaction-component-for-interaural-electrode-pairing-of-bilateral-cochlear-implants
#17
Hongmei Hu, Birger Kollmeier, Mathias Dietz
Although bilateral cochlear implants (BiCIs) have succeeded in improving the spatial hearing performance of bilateral CI users, the overall performance is still not comparable with normal hearing listeners. Limited success can be partially caused by an interaural mismatch of the place-of-stimulation in each cochlea. Pairing matched interaural CI electrodes and stimulating them with the same frequency band is expected to facilitate binaural functions such as binaural fusion, localization, or spatial release from masking...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26491026/smad4-defect-causes-auditory-neuropathy-via-specialized-disruption-of-cochlear-ribbon-synapses-in-mice
#18
Ke Liu, Fei Ji, Guan Yang, Zhaohui Hou, Jianhe Sun, Xiaoyu Wang, Weiwei Guo, Wei Sun, Weiyan Yang, Xiao Yang, Shiming Yang
More than 100 genes have been associated with deafness. However, SMAD4 is rarely considered a contributor to deafness in humans, except for its well-defined role in cell differentiation and regeneration. Here, we report that a SMAD4 defect in mice can cause auditory neuropathy, which was defined as a mysterious hearing and speech perception disorder in human for which the genetic background remains unclear. Our study showed that a SMAD4 defect induces failed formation of cochlear ribbon synapse during the earlier stage of auditory development in mice...
October 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26382170/objective-and-subjective-evaluations-of-the-nurotron-venus-cochlear-implant-system-via-animal-experiments-and-clinical-trials
#19
Na Gao, Xin-Da Xu, Fang-Lu Chi, Fan-Gang Zeng, Qian-Jie Fu, Xian-Hao Jia, Yan-Bo Yin, Li-Chuan Ping, Hou-Yong Kang, Hai-Hong Feng, Yong-Zhen Wu, Ye Jiang
CONCLUSION: This study described objective and subjective evaluations of the Nurotron® Venus™ Cochlear Implant System and indicated that this system produced a satisfactory performance. OBJECTIVE: To observe the performance of the Nurotron® Venus™ cochlear implant (CI) system via electrophysiological and psychophysical evaluations. METHODS: A 26-electrode CI system was specially designed. The performance of MRI in animal and cadaveric head experiments, EABR in cats experiment, the correlation between ESRT and C level, and psychophysics evaluations in clinical trials were observed...
2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26302945/interaural-stimulation-timing-in-single-sided-deaf-cochlear-implant-users
#20
S Zirn, S Arndt, A Aschendorff, T Wesarg
The interaural time difference (ITD) is an important cue for the localization of sounds. ITD changes as little as 10 μs can be detected by the human auditory system. By provision of one ear with a cochlear implant (CI) ITD are altered due to the partial replacement of the peripheral auditory system. A hearing aid (HA), in contrast, does not replace but adds a processing delay component to the peripheral auditory system extending ITD. The aim of the present study was to quantify interaural stimulation timing between these different modalities to estimate the need for central auditory temporal compensation in single sided deaf CI users or bimodal CI/HA users...
October 2015: Hearing Research
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