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https://www.readbyqxmd.com/read/27149268/a-cochlear-implant-performance-prognostic-test-based-on-electrical-field-interactions-evaluated-by-eabr-electrical-auditory-brainstem-responses
#1
Nicolas Guevara, Michel Hoen, Eric Truy, Stéphane Gallego
BACKGROUND: Cochlear implants (CIs) are neural prostheses that have been used routinely in the clinic over the past 25 years. They allow children who were born profoundly deaf, as well as adults affected by hearing loss for whom conventional hearing aids are insufficient, to attain a functional level of hearing. The "modern" CI (i.e., a multi-electrode implant using sequential coding strategies) has yielded good speech comprehension outcomes (recognition level for monosyllabic words about 50% to 60%, and sentence comprehension close to 90%)...
2016: PloS One
https://www.readbyqxmd.com/read/27080646/suitability-of-the-binaural-interaction-component-for-interaural-electrode-pairing-of-bilateral-cochlear-implants
#2
Hongmei Hu, Birger Kollmeier, Mathias Dietz
Although bilateral cochlear implants (BiCIs) have succeeded in improving the spatial hearing performance of bilateral CI users, the overall performance is still not comparable with normal hearing listeners. Limited success can be partially caused by an interaural mismatch of the place-of-stimulation in each cochlea. Pairing matched interaural CI electrodes and stimulating them with the same frequency band is expected to facilitate binaural functions such as binaural fusion, localization, or spatial release from masking...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26491026/smad4-defect-causes-auditory-neuropathy-via-specialized-disruption-of-cochlear-ribbon-synapses-in-mice
#3
Ke Liu, Fei Ji, Guan Yang, Zhaohui Hou, Jianhe Sun, Xiaoyu Wang, Weiwei Guo, Wei Sun, Weiyan Yang, Xiao Yang, Shiming Yang
More than 100 genes have been associated with deafness. However, SMAD4 is rarely considered a contributor to deafness in humans, except for its well-defined role in cell differentiation and regeneration. Here, we report that a SMAD4 defect in mice can cause auditory neuropathy, which was defined as a mysterious hearing and speech perception disorder in human for which the genetic background remains unclear. Our study showed that a SMAD4 defect induces failed formation of cochlear ribbon synapse during the earlier stage of auditory development in mice...
October 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26382170/objective-and-subjective-evaluations-of-the-nurotron-venus-cochlear-implant-system-via-animal-experiments-and-clinical-trials
#4
Na Gao, Xin-Da Xu, Fang-Lu Chi, Fan-Gang Zeng, Qian-Jie Fu, Xian-Hao Jia, Yan-Bo Yin, Li-Chuan Ping, Hou-Yong Kang, Hai-Hong Feng, Yong-Zhen Wu, Ye Jiang
CONCLUSION: This study described objective and subjective evaluations of the Nurotron® Venus™ Cochlear Implant System and indicated that this system produced a satisfactory performance. OBJECTIVE: To observe the performance of the Nurotron® Venus™ cochlear implant (CI) system via electrophysiological and psychophysical evaluations. METHODS: A 26-electrode CI system was specially designed. The performance of MRI in animal and cadaveric head experiments, EABR in cats experiment, the correlation between ESRT and C level, and psychophysics evaluations in clinical trials were observed...
2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26302945/interaural-stimulation-timing-in-single-sided-deaf-cochlear-implant-users
#5
S Zirn, S Arndt, A Aschendorff, T Wesarg
The interaural time difference (ITD) is an important cue for the localization of sounds. ITD changes as little as 10 μs can be detected by the human auditory system. By provision of one ear with a cochlear implant (CI) ITD are altered due to the partial replacement of the peripheral auditory system. A hearing aid (HA), in contrast, does not replace but adds a processing delay component to the peripheral auditory system extending ITD. The aim of the present study was to quantify interaural stimulation timing between these different modalities to estimate the need for central auditory temporal compensation in single sided deaf CI users or bimodal CI/HA users...
October 2015: Hearing Research
https://www.readbyqxmd.com/read/26257649/dendrogenin-a-and-b-two-new-steroidal-alkaloids-increasing-neural-responsiveness-in-the-deafened-guinea-pig
#6
Anette Fransson, Philippe de Medina, Michaël R Paillasse, Sandrine Silvente-Poirot, Marc Poirot, Mats Ulfendahl
AIM: To investigate the therapeutic potential for treating inner ear damage of two new steroidal alkaloid compounds, Dendrogenin A and Dendrogenin B, previously shown to be potent inductors of cell differentiation. METHODS: Guinea pigs, unilaterally deafened by neomycin infusion, received a cochlear implant followed by immediate or a 2-week delayed treatment with Dendrogenin A, Dendrogenin B, and, as comparison artificial perilymph and glial cell-line derived neurotrophic factor...
2015: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/26227924/a-microelectromechanical-system-artificial-basilar-membrane-based-on-a-piezoelectric-cantilever-array-and-its-characterization-using-an-animal-model
#7
Jongmoon Jang, JangWoo Lee, Seongyong Woo, David J Sly, Luke J Campbell, Jin-Ho Cho, Stephen J O'Leary, Min-Hyun Park, Sungmin Han, Ji-Wong Choi, Jeong Hun Jang, Hongsoo Choi
We proposed a piezoelectric artificial basilar membrane (ABM) composed of a microelectromechanical system cantilever array. The ABM mimics the tonotopy of the cochlea: frequency selectivity and mechanoelectric transduction. The fabricated ABM exhibits a clear tonotopy in an audible frequency range (2.92-12.6 kHz). Also, an animal model was used to verify the characteristics of the ABM as a front end for potential cochlear implant applications. For this, a signal processor was used to convert the piezoelectric output from the ABM to an electrical stimulus for auditory neurons...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26162414/delayed-auditory-brainstem-responses-in-prelingually-deaf-and-late-implanted-cochlear-implant-users
#8
Marc J W Lammers, Ruben H M van Eijl, Gijsbert A van Zanten, Huib Versnel, Wilko Grolman
Neurophysiological studies in animals and humans suggest that severe hearing loss during early development impairs the maturation of the auditory brainstem. To date, studies in humans have mainly focused on the neural activation of the auditory brainstem in children treated with a cochlear implant (CI), but little is known about the pattern of activation in adult CI users with early onset of deafness (prelingual, before the age of 2 years). In this study, we compare auditory brainstem activation in prelingually deaf and late-implanted adult CI users to that in postlingually deaf CI users...
October 2015: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/26103671/-the-relization-of-eabr-test-out-of-cochlea-and-the-effects-of-different-location-of-electrode-on-eabr-wave
#9
Ruxiang Zhang, Daoxing Zhang, Xiuyong Ding
OBJECTIVE: To investigate the feasibility of the round window stimulation electrical evoked auditory brainstem response (EABR) test, and optimize the parameters of recording and stimulation electrodes positions. METHOD: Ten healthy Hartley guinea pigs (20 ears) were used for the EABR test. The positive stimulation electrodes were placed into the round window niche, the animals were divided into three group according to the negative electrodes position, group A: the electric field was parallel with the projection of cochlear modiolus on the tympanic membrane, group B: the electric field was perpendicular to modiolus projection toward to the mastoid, group C: the electric field was perpendicular to modiolus projection toward to the zygomatic process...
March 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26067504/the-energy-saving-anaerobic-baffled-reactor-membrane-bioreactor-eabr-mbr-system-for-recycling-wastewater-from-a-high-rise-building
#10
Chavalit Ratanatamskul, Chakraphan Charoenphol
A novel energy-saving anaerobic baffled reactor-membrane bioreactor (EABR-MBR) system has been developed as a compact biological treatment system for reuse of water from a high-rise building. The anaerobic baffled reactor (ABR) compartment had five baffles and served as the anaerobic degradation zone, followed by the aerobic MBR compartment. The total operating hydraulic retention time (HRT) of the EABR-MBR system was 3 hours (2 hours for ABR compartment and very short HRT of 1 hour for aerobic MBR compartment)...
2015: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/26062093/usefulness-of-measuring-electrically-evoked-auditory-brainstem-responses-in-children-with-inner-ear-malformations-during-cochlear-implantation
#11
Shujiro B Minami, Hideki Takegoshi, Yukiko Shinjo, Chieko Enomoto, Kimitaka Kaga
CONCLUSIONS: EABR is a reliable and effective way of objectively confirming device function and implant-responsiveness of the peripheral auditory neurons up to the level of the brainstem in cases of inner ear malformation. OBJECTIVE: To investigate the usefulness of measuring the intra-operative electrically evoked compound action potential (ECAP) and electrically evoked auditory brainstem response (EABR) in patients with and without congenital inner ear anomalies during cochlear implantation...
2015: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/25963359/auditory-rehabilitation-in-rhesus-macaque-monkeys-macaca-mulatta-with-auditory-brainstem-implants
#12
Zhen-Min Wang, Zhi-Jun Yang, Fu Zhao, Bo Wang, Xing-Chao Wang, Pei-Ran Qu, Pi-Nan Liu
BACKGROUND: The auditory brainstem implants (ABIs) have been used to treat deafness for patients with neurofibromatosis Type 2 and nontumor patients. The lack of an appropriate animal model has limited the study of improving hearing rehabilitation by the device. This study aimed to establish an animal model of ABI in adult rhesus macaque monkey (Macaca mulatta). METHODS: Six adult rhesus macaque monkeys (M. mulatta) were included. Under general anesthesia, a multichannel ABI was implanted into the lateral recess of the fourth ventricle through the modified suboccipital-retrosigmoid (RS) approach...
May 20, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/25798647/prognostic-value-of-electrically-evoked-auditory-brainstem-responses-in-cochlear-implantation
#13
Karin Lundin, Fredrik Stillesjö, Helge Rask-Andersen
OBJECTIVES: The aim of this study was to investigate whether electrical auditory brainstem responses (eABRs) obtained during cochlear implantation (CI) can predict CI outcomes. We also aimed to assess whether eABR can be used to select patients for auditory brainstem implantation (ABI). METHODS: This was a retrospective study. The latencies and quality of the eABR waveforms from adult patients implanted with CI in Uppsala from 2011 to 2013 (n = 74) and four children with severe cochlear abnormalities were analyzed...
September 2015: Cochlear Implants International
https://www.readbyqxmd.com/read/25681972/fabrication-and-evaluation-of-an-improved-polymer-based-cochlear-electrode-array-for-atraumatic-insertion
#14
Tae Mok Gwon, Kyou Sik Min, Jin Ho Kim, Seung Ha Oh, Ho Sun Lee, Min-Hyun Park, Sung June Kim
An atraumatic cochlear electrode array has become indispensable to high-performance cochlear implants such as electric acoustic stimulation (EAS), wherein the preservation of residual hearing is significant. For an atraumatic implantation, we propose and demonstrate a new improved design of a cochlear electrode array based on liquid crystal polymer (LCP), which can be fabricated by precise batch processes and a thermal lamination process, in contrast to conventional wire-based cochlear electrode arrays. Using a thin-film process of LCP-film-mounted silicon wafer and thermal press lamination, we devise a multi-layered structure with variable layers of LCP films to achieve a sufficient degree of basal rigidity and a flexible tip...
April 2015: Biomedical Microdevices
https://www.readbyqxmd.com/read/25677645/the-relationship-between-eabr-and-auditory-performance-and-speech-intelligibility-outcomes-in-pediatric-cochlear-implant-recipients
#15
Yu Wang, Tao Pan, Shruti Balvalli Deshpande, Furong Ma
PURPOSE: The primary purpose of the present study was to investigate the relationship between postimplant electrically evoked auditory brainstem response (EABR) measures (wave V threshold, wave V latency, input-output functions) and auditory performance and speech intelligibility outcomes measured using parental rating scales, such as Categories of Auditory Performance (CAP; Archbold, Lutman, & Marshall, 1995) and the Speech Intelligibility Rating scale (SIR; Allen, Nikolopoulos, Dyar, & O'Donoghue, 2001), respectively...
June 2015: American Journal of Audiology
https://www.readbyqxmd.com/read/25634467/usefulness-of-mri-and-eabr-testing-for-predicting-ci-outcomes-immediately-after-cochlear-implantation-in-cases-with-cochlear-nerve-deficiency
#16
Hiroshi Yamazaki, Jaime Leigh, Robert Briggs, Yasushi Naito
OBJECTIVE: Cochlear nerve deficiency (CND) is often associated with poor cochlear implant (CI) outcomes, and patients with CND may be candidates for auditory brainstem implantation (ABI). The purpose of this study was to identify investigations which predict CI outcomes immediately after cochlear implantation to recommend ABI within the critical period of auditory development when cochlear implantation precedes ABI. STUDY DESIGN: Retrospective case review. SETTING: Cochlear implant centers at tertiary referral hospitals...
July 2015: Otology & Neurotology
https://www.readbyqxmd.com/read/25623869/-development-of-electrically-evoked-auditory-brainstem-response-modules-of-rez-i-domestic-cochlear-implant-device
#17
Xiuyong Ding, Ruxiang Zhang, Changjian Xu, Wei Fan, Daoxing Zhang
OBJECTIVE: To develop electrically evoked auditory brainstem response(EABR) modules of REZ-I domestic cochlear implant device, and testify the reliability and validity of the modules. METHODS: Postoperative EABR were recorded in guinea pigs by using the self-designed EABR module. RESULTS: EABR waves were recorded in all 15 ears of 9 guinea pigs with normal hearing. The threshold was (159.00 ± 50.21) current level (CL) and eIII wave latency was (2...
December 2014: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/25508185/-surgery-and-electroneurophysiological-evaluation-for-ci-case-with-modiolus-ossification
#18
Daoxing Zhang
OBJECTIVE: The purpose of this study is to report surgical skills for CI cases with modiolus ossification and to investigate the relation between post-operational electroneurophysilogical test result and speech recognition result. Further more, we also attempt to confirm indications for CI in this specific population. METHOD: Based on temporal bone HRCT, 7 subjects were identified as modiolus ossification from 101 cases with cochlear ossification. Modiolus ossification is confirmed by CT scan if CT value in modiolus reaches or exceeds 900 HU with the exception of congenital modiolus ossification or modiolus seal off...
August 2014: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/25473959/auditory-brainstem-implantation-in-a-16-month-old-boy-with-cochlear-hypoplasia
#19
Sidharth V Puram, Aaron D Tward, David H Jung, Amanda E Dilger, Barbara S Herrmann, Ann-Christine Duhaime, Fred G Barker, Daniel J Lee
OBJECTIVE: To determine the safety and feasibility of auditory brainstem implantation in children younger than 5 years. PATIENT(S): Patients younger than 5 years who were not candidates for cochlear implantation because of anatomic considerations were included in the analyses. INTERVENTION(S): Auditory brainstem implantation via retrosigmoid craniotomy. MAIN OUTCOME MEASURE(S): Audiologic, speech, quality of life, and safety outcomes were assessed...
April 2015: Otology & Neurotology
https://www.readbyqxmd.com/read/25464554/-surgery-and-electroneurophysiological-evaluation-for-ci-case-with-modiolus-ossification
#20
Daoxing Zhang
OBJECTIVE: The purpose of this study is to report surgical skills for CI cases with modiolus ossification and to investigate the relation between post-operational electroneurophysilogical test result and speech recognition result. Further more, we also attempt to confirm indications for CI in this specific population. METHOD: Based on temporal bone HRCT, 7 subjects were identified as modiolus ossification from 101 cases with cochlear ossification. Modiolus ossification is confirmed by CT scan if CT value in modiolus reaches or exceeds 900 HU with the exception of congenital modiolus ossification or modiolus seal off...
August 2014: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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