keyword
MENU ▼
Read by QxMD icon Read
search

Inhalation

keyword
https://www.readbyqxmd.com/read/29906556/antinociceptive-effect-of-inhalation-of-the-essential-oil-of-bergamot-in-mice
#1
Damiana Scuteri, Michele Crudo, Laura Rombolà, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Tsukasa Sakurada, Rosaria Greco, Maria Tiziana Corasaniti, Luigi Antonio Morrone, Giacinto Bagetta
Bergamot essential oil (BEO) has proven wide evidence of pharmacological antinociceptive effectiveness both in nociceptive and in neuropathic pain models. The antinociceptive properties of BEO for inhalation have not been investigated. The purpose of this study is to evaluate the effects of the inhalation of BEO on formalin-induced nociceptive response in mice. Male ddY-strain mice (Japan SLC, Hamamatsu, Japan) of 23-25 g of weight at the time the experiments underwent the formalin test. Twenty μL of formalin (2% in saline) were administered into the plantar surface of the mice hindpaw and the time of licking/biting was observed and recorded at intervals of 5 min...
June 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29906536/mahuang-decoction-mitigates-airway-inflammation-and-regulates-il-21-stat3-signaling-pathway-in-rat-asthma-model
#2
Yu He, Xiaohui Lou, Zhan Jin, Li Yu, Ling Deng, Haitong Wan
ETHNOPHARMACOLOGICAL RELEVANCE: Nowadays, bronchial asthma is still a severe disease threatening human health, and it is incumbent upon us to seek effective therapeutic drugs. Mahuang decoction (MHD), a classic famous Chinese prescription, has been used for thousands of years to prevent phlegm from forming, stop coughing and relieve asthma, but the relevant mechanism has not been thoroughly clarified. This study aims to investigate the anti-airway inflammation effect of MHD and the possible molecular mechanism underlying IL21/STAT3 signaling pathway, so as to provide guidance for the treatment of MHD on bronchial asthma...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29906501/repurposing-drugs-as-inhaled-therapies-in-asthma
#3
Sandra D Anderson
For the first 40 years of the 20th century treatment for asthma occurred in response to an asthma attack. The treatments were given by injection or orally and included the adrenergic agonists adrenalin/epinephrine and ephedrine and a phosphodiesterase inhibitor theophylline. Epinephrine became available as an aerosol in 1930. After 1945, isoprenaline, a non-selective beta agonist, became available for oral use but it was most widely used by inhalation. Isoprenaline was short-acting with unwanted cardiac effects...
June 12, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29906340/sympatho-excitatory-response-to-pulmonary-chemosensitive-spinal-afferent-activation-in-anesthetized-vagotomized-rats
#4
Julia Shanks, Zhiqiu Xia, Steven J Lisco, George J Rozanski, Harold D Schultz, Irving H Zucker, Han-Jun Wang
The sensory innervation of the lung is well known to be innervated by nerve fibers of both vagal and sympathetic origin. Although the vagal afferent innervation of the lung has been well characterized, less is known about physiological effects mediated by spinal sympathetic afferent fibers. We hypothesized that activation of sympathetic spinal afferent nerve fibers of the lung would result in an excitatory pressor reflex, similar to that previously characterized in the heart. In this study, we evaluated changes in renal sympathetic nerve activity (RSNA) and hemodynamics in response to activation of TRPV1-sensitive pulmonary spinal sensory fibers by agonist application to the visceral pleura of the lung and by administration into the primary bronchus in anesthetized, bilaterally vagotomized, adult Sprague-Dawley rats...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29905977/inspiromatic-safety-and-efficacy-study-of-a-new-generation-dry-powder-inhaler-in-asthmatic-children
#5
Guy Steuer, Dario Prais, Huda Mussaffi, Meir Mei-Zahav, Ophir Bar-On, Hagit Levine, Yulia Gendler, Hannah Blau, Patrick Stafler
BACKGROUND: Dry powder inhalers (DPI) are effective but forceful inhalation required to fluidize the powder may be difficult for children and patients with airway disease. Inspiromatic is a new generation active DPI that actively suspends drugs in synchrony with inhalation. We evaluated safety and efficacy of Formoterol delivery via Inspiromatic, compared to Aerolizer, a conventional DPI, in pediatric asthmatic subjects. METHODS: A phase I/II, randomized, single-center, double-blind, double-dummy, placebo-controlled, cross-over study...
June 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29905773/an-evaluation-of-the-relationship-among-urine-air-and-hand-measures-of-exposure-to-bisphenol-a-bpa-in-us-manufacturing-workers
#6
Cynthia J Hines, Annette L Christianson, Matthew V Jackson, Xiaoyun Ye, Jack R Pretty, James E Arnold, Antonia M Calafat
Background: Exposure to bisphenol A (BPA) can be assessed using external and internal exposure measures. We examined the relationship between two measures of external BPA exposure (air and hand-wipe samples) and one of internal exposure (total BPA in urine) for a group of US manufacturing workers. Methods: During 2013-2014, we recruited 78 workers from six US companies that made BPA or made products with BPA. We quantified BPA in seven urine samples, two full-shift air samples and in pre- and end-shift hand-wipe samples collected from workers over 2 consecutive days...
June 13, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29905673/blood-brain-barrier-dysfunction-after-smoke-inhalation-injury-with-and-without-skin-burn
#7
Anita C Randolph, Satoshi Fukuda, Koji Ihara, Perenlei Enkhbaatar, Maria-Adelaide Micci
Only a handful of published reports exist today that describe neurological complications following smoke inhalation injury. In this study, we characterize acute pathophysiological changes in the brain of sheep exposed to smoke inhalation, with- and without third-degree skin burn that models the injuries sustained by human victims of fire accidents. Blood-brain barrier integrity and hemorrhage were analyzed throughout the brain using specific histological stains: Hematoxylin & Eosin, Luxol fast blue, Periodic acid-Schiff (PAS), and Martius, Scarlet and Blue (MSB)...
June 13, 2018: Shock
https://www.readbyqxmd.com/read/29904643/prevalidation-of-an-acute-inhalation-toxicity-test-using-the-epiairway-in-vitro-human-airway-model
#8
George R Jackson, Anna G Maione, Mitchell Klausner, Patrick J Hayden
Introduction: Knowledge of acute inhalation toxicity potential is important for establishing safe use of chemicals and consumer products. Inhalation toxicity testing and classification procedures currently accepted within worldwide government regulatory systems rely primarily on tests conducted in animals. The goal of the current work was to develop and prevalidate a nonanimal ( in vitro ) test for determining acute inhalation toxicity using the EpiAirway™ in vitro human airway model as a potential alternative for currently accepted animal tests...
June 1, 2018: Applied in Vitro Toxicology
https://www.readbyqxmd.com/read/29904421/contrast-enhanced-magnetic-resonance-imaging-with-a-novel-nano-size-contrast-agent-for-the-clinical-diagnosis-of-patients-with-lung-cancer
#9
Jianwei Gao, Lei Li, Xia Liu, Rui Guo, Bin Zhao
Recent studies have indicated that magnetic resonance imaging (MRI) efficiently diagnoses lung cancer. However, the efficacy of MRI in diagnosing lung cancer requires improving for patients in the early stage of the disease. In the present study, a novel nano-sized contrast agent of chistosan/Fe3 O4 -enclosed bispecific antibodies (BsAbCENS) was introduced, which targeted carcino-embryonic antigen (CEA) and neuron-specific enolase (NSE) in lung cancer cells. The diagnostic efficacy of contrast-enhanced MRI with BsAbCENS (CEMRI-BsAbCENS) was investigated in a total of 182 patients with suspected lung cancer who had high serum levels of CEA and NSE...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29903734/ige-to-the-mammalian-oligosaccharide-galactose-%C3%AE-1-3-galactose-is-associated-with-increased-atheroma-volume-and-plaques-with-unstable-characteristics
#10
Jeffrey M Wilson, Anh T Nguyen, Alexander J Schuyler, Scott P Commins, Angela M Taylor, Thomas A E Platts-Mills, Coleen A McNamara
OBJECTIVE: Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal)-the target allergen of delayed anaphylaxis to red meat-is associated with coronary artery disease. APPROACH AND RESULTS: Total IgE and specific IgE to α-Gal were assayed on sera from 118 subjects who presented for cardiac catheterization and underwent intravascular ultrasound...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29903600/revisiting-extracorporeal-membrane-oxygenation-for-ards-in-burns-a-case-series-and-review-of-the-literature
#11
Craig R Ainsworth, Jeffrey Dellavolpe, Kevin K Chung, Leopoldo C Cancio, Phillip Mason
INTRODUCTION: Recent reports on the use of extracorporeal membrane oxygenation (ECMO) in critically ill burn patients with Acute Respiratory Distress Syndrome (ARDS) recommended against the use of ECMO. The authors cited the high mortality rates associated with the use of ECMO in these patients with no appreciable benefit. Accumulating evidence from referral centers suggests improved survival in patients with ARDS receiving ECMO. We report our recent experience treating patients with severe ARDS with ECMO in a burn intensive care unit...
June 11, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29902799/is-cannabis-use-treatment-also-indicated-for-patients-with-low-to-moderate-polysubstance-use
#12
Maria Neumann, Gerhard Bühringer, Michael Höfler, Hans-Ulrich Wittchen, Eva Hoch
BACKGROUND: Polysubstance use (PSU) is common among patients with cannabis use (CU) and is related to more severe CU problems. However, it is unclear how PSU predicts CU treatment outcomes beyond CU patterns. We examined the frequency, amount, and class of additionally used substances as predictors for primary and secondary outcomes. METHODS: We conducted crude and adjusted regression analyses for PSU variables as predictors of remission, abstinence, -reduction, and secondary outcomes in 166 help-seeking -patients from a randomized clinical trial of CANDIS, a -cognitive behavioral treatment program...
June 14, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29902699/abuse-of-fentanyl-an-emerging-problem-to-face
#13
REVIEW
Katarzyna Kuczyńska, Piotr Grzonkowski, Łukasz Kacprzak, Jolanta B Zawilska
Fentanyl is a potent synthetic opioid used as a narcotic analgesic supplement in general and regional anesthesia as well as in management of persistent, severe chronic pain. Alarming epidemiological and forensic medicine reports, accumulated mainly during the last two decades, point to a growing increase in illicit use of fentanyl, mainly in North America and Europe. Toxicological data indicates that fentanyl use is inextricably linked with polydrug use. There are two main sources of fentanyl on the "recreational" drug market...
June 2, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29902546/review-surgical-smoke-risks-assessment-and-mitigation-strategies
#14
REVIEW
Corey Georgesen, Shari R Lipner
BACKGROUND: Although many dermatologic surgeons are aware of the risks of surgical smoke, many do not employ hazard reduction strategies. OBJECTIVE: To identify the infectious, inhalational, chemical, and mutagenic risks of surgical smoke in dermatologic procedures and suggest evidence based hazard reduction strategies. METHODS: A review of articles indexed for MEDLINE on PubMed using keywords "surgical smoke", "dermatology", "surgical mask", "respirator", "smoke evacuator", and "guidelines" was performed in 13 combinations using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols...
June 11, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29902195/theoretical-open-loop-model-of-respiratory-mechanics-in-the-extremely-preterm-infant
#15
Laura Ellwein Fix, Joseph Khoury, Russell R Moores, Lauren Linkous, Matthew Brandes, Henry J Rozycki
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to their markedly increased chest wall compliance that does not provide enough structure against which the forces of inhalation can generate sufficient pressure. To address the continued challenge of studying treatments in this fragile population, we developed a nonlinear lumped-parameter respiratory system mechanics model of the extremely preterm infant that incorporates nonlinear lung and chest wall compliances and lung volume parameters tuned to this population...
2018: PloS One
https://www.readbyqxmd.com/read/29902079/hydrogen-gas-improves-left-ventricular-hypertrophy-in-dahl-rat-of-salt-sensitive-hypertension
#16
Hiroki Matsuoka, Seiko Miyata, Nozomi Okumura, Takuya Watanabe, Katsunori Hashimoto, Miki Nagahara, Kazuko Kato, Sayaka Sobue, Kozue Takeda, Masatoshi Ichihara, Takashi Iwamoto, Akiko Noda
PURPOSE: Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure. Hydrogen (H2 ) gas protects against many diseases, including ischemia-reperfusion injury and stroke. The effects of H2 on hypertension and its related left ventricular (LV) function have not been fully elucidated. The purpose of this study was to investigate the effects of H2 gas on hypertension and LV hypertrophy using echocardiography. METHODS: Dahl salt-sensitive (DS) rats were randomly divided into three groups: those fed an 8% NaCl diet until 12 weeks of age (8% NaCl group), those additionally treated with H2 gas (8% NaCl + H2 group), and control rats maintained on a diet containing 0...
June 14, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29901860/pharmacokinetics-of-co-suspension-delivery-technology-budesonide-glycopyrronium-formoterol-fumarate-dihydrate-bgf-mdi-and-budesonide-formoterol-fumarate-dihydrate-bff-mdi-fixed-dose-combinations-compared-with-an-active-control-a-phase-1-randomized-single-dose
#17
Andrea Maes, Paolo DePetrillo, Shahid Siddiqui, Colin Reisner, Paul Dorinsky
This randomized, phase 1, single-dose, crossover study (NCT02189304) compared the 12-hour pharmacokinetic (PK) and safety profiles of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler (BGF MDI) 320/14.4/10 μg and budesonide/formoterol fumarate dihydrate (BFF) MDI 320/10 μg (both formulated using innovative co-suspension delivery technology) to an active comparator (budesonide/formoterol fumarate dihydrate dry powder inhaler [BUD/FORM DPI] 320/9-μg delivered dose) in healthy adults...
June 14, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29901798/the-use-of-extracorporeal-membrane-oxygenation-for-acute-respiratory-distress-syndrome-in-severe-burns-without-inhalation-injury
#18
Juliet J Ray, Richard J Straker, Valerie J Hart, Jonathan P Meizoso, Carl I Schulman, Matthias Loebe, Ali Ghodsizad
Burn injury results in a severe systemic inflammatory response which is associated with the development of acute respiratory distress syndrome (ARDS), even without associated inhalation injury. Venous-venous extracorporeal membrane oxygenation (VV-ECMO) has been implemented in various cases of ARDS to provide support and allow for protective lung ventilation strategies. We report the case of a 27-year-old man presenting with a 60% total body surface area partial thickness burn who developed refractory ARDS with Murray Score of 3...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29901406/recommendations-for-initiating-use-of-afrezza-inhaled-insulin-in-individuals-with-type-1-diabetes
#19
Jeremy Pettus, Tricia Santos Cavaiola, Steven V Edelman
Treatment with Afrezza® (insulin human) inhalation powder in individuals with type 1 diabetes (T1D) reduces HbA1c levels similar to rapid-acting insulin analogs, but with significantly less hypoglycemia due to its unique time action profile. Examinations of studies of Afrezza pharmacokinetics/pharmacodynamics, relevant clinical trials, and U.S. Food and Drug Administration (FDA) documentation suggest that current FDA-mandated dosing recommendations for initiating Afrezza treatment may not result in optimal glycemic control for individuals with T1D...
June 14, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29899047/self-management-of-patients-with-mild-copd-in-primary-care-randomised-controlled-trial
#20
Kate Jolly, Manbinder S Sidhu, Catherine A Hewitt, Peter A Coventry, Amanda Daley, Rachel Jordan, Carl Heneghan, Sally Singh, Natalie Ives, Peymane Adab, Susan Jowett, Jinu Varghese, David Nunan, Khaled Ahmed, Lee Dowson, David Fitzmaurice
OBJECTIVE: To evaluate the effectiveness of telephone health coaching delivered by a nurse to support self management in a primary care population with mild symptoms of chronic obstructive pulmonary disease (COPD). DESIGN: Multicentre randomised controlled trial. SETTING: 71 general practices in four areas of England. PARTICIPANTS: 577 patients with Medical Research Council dyspnoea scale scores of 1 or 2, recruited from primary care COPD registers with spirometry confirmed diagnosis...
June 13, 2018: BMJ: British Medical Journal
keyword
keyword
38519
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"