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https://www.readbyqxmd.com/read/29228436/the-effect-of-ventilator-mask-atomization-inhalation-of-ipratropium-bromide-and-budesonide-suspension-liquid-in-the-treatment-of-copd-in-acute-exacerbation-period-on-circulating-levels-of-inflammation-and-prognosis
#1
D-H Jiang, X Wang, L-S Liu, D-D Ji, N Zhang
OBJECTIVE: We investigated the effects of ventilator mask atomization inhalation of ipratropium bromide and budesonide suspension liquid in the treatment of acute exacerbation COPD (AECOPD) on circulating levels of inflammatory factors and prognosis. PATIENTS AND METHODS: A total of 86 cases of patients on ventilator support were randomly divided into control group and observation group with 43 cases each. The control group was administered routine treatment including basic disease treatment, anti-infection, maintenance of a stable internal environment, nutritional support, oxygen inhalation and so on...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228347/exposure-of-mice-to-1-2-dichloropropane-induces-cyp450-dependent-proliferation-and-apoptosis-of-cholangiocytes
#2
Xiao Zhang, Cai Zong, Lingyi Zhang, Edwin Garner, Shigeyuki Sugie, Chinyen Huang, Wenting Wu, Jie Chang, Toshihiro Sakurai, Masashi Kato, Sahoko Ichihara, Shinji Kumagai, Gaku Ichihara
1, 2-Dichloropropane (1, 2-DCP) has been used as a paint remover in the industry. The International Agency for Research on Cancer reclassified this compound recently to Group 1 (carcinogenic to humans) based on epidemiological studies of cholangiocarcinoma among offset-color proof-printing workers exposed to 1, 2-DCP in Japan. Two-year rodent carcinogenicity bioassays demonstrated that 1, 2-DCP induced tumors in liver and lung, but not in bile duct. The present study was designed to assess the toxic effects of 1, 2-DCP on proliferation and apoptosis in mice bile duct and the role of cytochrome P450 (CYP450) in any such effect...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29227727/a-randomized-clinical-trial-comparing-the-ellipta-and-handihaler-dry-powder-inhalers-in-patients-with-copd-inhaler-specific-attributes-and-overall-patient-preference
#3
Kathryn A Collison, Pinal Patel, Andrew F Preece, Richard H Stanford, Raj K Sharma, Gregory Feldman
This randomised, open-label, cross-over, placebo-containing inhaler study assessed patient preference indicators for ELLIPTA and HandiHaler dry powder inhalers in patients with COPD (NCT02786927; GSK identifier: 204983). The primary objective of this study was to assess patient preference between ELLIPTA and HandiHaler based on the number of steps needed to use the inhaler. Eligible patients ≥40 years of age with COPD were randomised 1:1 to receive their current COPD medication plus a placebo-containing ELLIPTA or HandiHaler inhaler once daily for 7 ± 2 days (treatment period 1); this was followed by a 7 ± 2-day placebo treatment with the alternative inhaler...
December 11, 2017: COPD
https://www.readbyqxmd.com/read/29227637/urban-organic-aerosol-exposure-spatial-variations-in-composition-and-source-impacts
#4
Hugh Z Li, Timothy R Dallmann, Xiang Li, Peishi Gu, Albert A Presto
We conducted a mobile sampling campaign in a historically industrialized terrain (Pittsburgh, PA) targeting spatial heterogeneity of organic aerosol. Thirty-six sampling sites were chosen based on stratification of traffic, industrial source density, and elevation. We collected organic carbon (OC) on quartz filters, quantified different OC components with thermal-optical analysis, and grouped them based on volatility in decreasing order (OC1, OC2, OC3, OC4, and pyrolyzed carbon (PC)). We compared our ambient OC concentrations (both gas and particle phase) to similar measurements from vehicle dynamometer tests, cooking emissions, biomass burning emissions, and a highway traffic tunnel...
December 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29227315/inhaled-anesthetics-in-acute-lung-injury
#5
Ameeka Pannu, Brian O'Gara
No abstract text is available yet for this article.
2018: International Anesthesiology Clinics
https://www.readbyqxmd.com/read/29227043/the-association-of-air-pollutants-and-allergic-and-nonallergic-rhinitis-in-chronic-rhinosinusitis
#6
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas M Kaffenberger, Thomas J Willson, Stella E Lee
BACKGROUND: There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity. METHODS: CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial modeling from pollutant monitoring sites was used to estimate exposures for patients meeting the inclusion criteria (total, n = 125; CRSsNP, n = 67; CRSsNP, n = 58)...
December 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29225322/immunohistochemical-study-on-the-secretory-host-defense-system-with-lysozyme-and-secretory-phospholipase-a2-throughout-rat-respiratory-tract
#7
Natsumi Masuda, Youhei Mantani, Chiaki Yoshitomi, Hideto Yuasa, Miho Nishida, Masaya Arai, Junichi Kawano, Toshifumi Yokoyama, Nobuhiko Hoshi, Hiroshi Kitagawa
The host defense system with lysozyme and secretory phospholipase A2 (sPLA2) was immunohistochemically investigated in rat respiratory tract under healthy conditions. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NC) and a small number of goblet cells (GC) were immunopositive for lysozyme and sPLA2. A few acinar cells and almost all epithelial cells of intercalated ducts were immunopositive for both bactericidal substances in the nasal glands. In the laryngeal and tracheal epithelia, few NC and GC were immunopositive for both bactericidal substances...
December 8, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29224733/validated-maldi-tof-ms-method-for-anthrax-lethal-factor-provides-early-diagnosis-and-evaluation-of-therapeutics
#8
Maribel Gallegos-Candela, Anne E Boyer, Adrian R Woolfitt, Judy Brumlow, Renato C Lins, Conrad P Quinn, Alex R Hoffmaster, Gabriel Meister, John R Barr
Anthrax lethal factor (LF) is a zinc-dependent endoprotease and a critical virulence factor for Bacillus anthracis, the causative agent of anthrax. The mass spectrometry (MS) method for total-LF quantification includes three steps; 1) LF specific antibody capture/concentration, 2) LF-specific hydrolysis of a peptide substrate, and 3) detection and quantification of LF-cleaved peptides by isotope-dilution MALDI-TOF/MS. Recombinant LF spiked plasma was used for calibration and quality control (QC) materials. Specificity was 100% from analysis of serum and plasma from 383 non-infected humans, 31 rabbits, and 24 rhesus macaques...
December 7, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29224711/-risk-factors-associated-with-anesthesia-emergence-delirium-in-children-undergoing-outpatient-surgery
#9
Ana Carolina Tavares Paes Barreto, Ana Carolina Rangel da Rocha Paschoal, Carolina Barbosa Farias, Paulo Sérgio Gomes Nogueira Borges, Rebeca Gonelli Albanez da Cunha Andrade, Flávia Augusta de Orange
INTRODUCTION: Anesthesia emergence delirium (AED) is a self-limiting clinical phenomenon very common in children. Although pathophysiology is still uncertain, some factors seem to be involved, such as rapid awakening in an unknown environment, agitation during anesthetic induction, preoperative anxiety, environmental disorders, use of preanesthetic medication, use of inhalational anesthetics, and postoperative pain. OBJECTIVE: To determine the prevalence and risk factors associated with AED in children undergoing outpatient surgery...
December 7, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29224407/quantification-of-regional-aerosol-deposition-patterns-as-a-function-of-aerodynamic-particle-size-in-rhesus-macaques-using-pet-ct-imaging
#10
P A Dabisch, Z Xu, J A Boydston, J Solomon, J K Bohannon, J J Yeager, J R Taylor, R J Reeder, P Sayre, J Seidel, D J Mollura, M C Hevey, P B Jahrling, M G Lackemeyer
Aerosol aerodynamic particle size is known to affect deposition patterns of inhaled aerosol particles, as well as the virulence of inhaled bioaerosol particles. While a significant amount of work has been performed to describe the deposition of aerosol particles in the human respiratory tract, only a limited amount of work has been performed to describe the deposition of aerosol particles in the respiratory tract of nonhuman primates, an animal model commonly utilized in pharmacological and toxicological studies, especially in the biodefense field...
December 11, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29224252/are-inhaled-steroids-safe-and-effective-for-prevention-or-treatment-of-bronchopulmonary-dysplasia
#11
Eric S Shinwell
Bronchopulmonary Dysplasia (BPD) represents a major threat to the short and long-term health and development of very preterm infants. Unfortunately, despite much study and progress in neonatology in recent years and some modest improvements in survival, both the incidence and severity of BPD remain frustratingly stable (1). This article is protected by copyright. All rights reserved.
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29223575/a-comparison-between-inhalational-desflurane-and-total-intravenous-anaesthesia-propofol-and-dexmedetomidine-in-improving-postoperative-recovery-for-morbidly-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-a-double-blinded-randomised-controlled-trial
#12
Abd-Elazeem Elbakry, Wesam-Eldin Sultan, Ezzeldin Ibrahim
STUDY OBJECTIVE: Laparoscopic sleeve gastrectomy is commonly performed under total intravenous anaesthesia (TIVA) or balanced anaesthesia using an intravenous and inhalation agent. It is still unclear which anaesthesia regimen is better for this group of patients. The present study has been conducted to compare the use of the inhalation anaesthesia technique using desflurane with the TIVA technique, using propofol and dexmedetomidine. DESIGN: Prospective, randomised, double-blinded study...
December 7, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29223508/on-the-pharmacokinetics-of-two-inhaled-budesonide-formoterol-combinations-in-asthma-patients-using-modeling-approaches
#13
K Soulele, P Macheras, V Karalis
Dry powder inhalers containing the budesonide/formoterol combination have currently a well-established position among other inhaled products. Even though their efficacy mainly depends on the local concentrations of the drug they deliver within the lungs, their safety profile is directly related to their total systemic exposure. The aim of the present investigation was to explore the absorption and disposition kinetics of the budesonide/formoterol combination delivered via two different dry powder inhalers in asthma patients...
December 6, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29223148/exhaled-nitric-oxide-helps-discriminating-asthmatic-children-with-and-without-positive-specific-ige-to-aeroallergens
#14
Li-Ching Fang, Shyh-Dar Shyur, Jun Yang, Jen-Yu Wang, Yu-Hsuan Kao, Chien-Hui Yang, Yu-Ting Yu
BACKGROUND: Aeroallergen sensitization may predict higher fractional exhaled nitric oxide (FeNO) levels. OBJECTIVE: We evaluate cut-off values of FeNO in asthmatic children with and without positive specific immunoglobulin E (IgE) to at least one of 5 aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, and cockroach). METHODS: 564 patients with asthma and allergic rhinitis (AR) aged 5 to 18 years were enrolled into two groups...
December 10, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29223101/cognitive-impairment-measured-by-event-related-potentials-during-early-and-late-postoperative-period-following-intravenous-or-inhalation-anaesthesia
#15
Irena Holečková, Jakub Kletečka, David Štěpánek, Slavomír Žídek, David Bludovský, Jiří Pouska, Pavel Mautner, Vladimír Přibáň
OBJECTIVE: This study investigated modification in cognitive function following inhalation (IA) and total intravenous (TIVA) anaesthesia measured using auditory ERPs (Event Related Potentials). METHODS: Auditory ERPs examination with N1, P3a and P3b component registration was carried out one day before surgery (D-1) and on the first (D+1), sixth (D+6) and 42nd (D+42) days after surgery. Results were compared between two anaesthetic groups. RESULTS: On D+1, N1 latency was increased in the IA group...
November 16, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29222682/-three-dimensional-analysis-of-nasal-physiology-representation-by-means-of-computational-fluid-dynamics
#16
REVIEW
F Sommer, T K Hoffmann, G Mlynski, M Reichert, A-S Grossi, R Kröger, J Lindemann
The human nose takes primary responsibility for preconditioning inhaled air. Numerous pathologies can affect the physiology of the nose. The beginnings of flow analyzes were carried out with three-dimensional casting models and differently colored liquids. Temperature and humidity could not be taken into account. Today, much more complex analyzes are possible using computational fluid dynamics (CFD), which are based on three-dimensional models generated from computed tomography (CT) or magnetic resonance imaging (MRI) datasets...
December 8, 2017: HNO
https://www.readbyqxmd.com/read/29222627/pediatric-asthma-management-in-china-current-and-future-challenges
#17
Xiaojian Zhou, Jianguo Hong
The purpose of this report was to review the state of asthma diagnosis and treatment in China and to examine challenges in achieving earlier diagnosis and treatment. The prevalence of asthma in children in China has increased over past decades, and data published in 2013 indicated a prevalence of 3.0% in children aged 0-14 years. Although this prevalence has increased, the percentage of children with acute asthma attacks decreased from 86% in 2000 to 77% in 2010, and the frequency of hospitalizations for asthma attacks decreased from 54...
December 8, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29221966/lesion-magnetic-susceptibility-response-to-hyperoxic-challenge-a-biomarker-for-malignant-brain-tumor-microenvironment
#18
Pinar Senay Özbay, Sonja Stieb, Cristina Rossi, Oliver Riesterer, Andreas Boss, Tobias Weiss, Felix Kuhn, Klaas Paul Pruessmann, Daniel Nanz
BACKGROUND AND PURPOSE: Quantitative susceptibility mapping has been previously used to differentiate lesions in patients with brain tumors. The aim of this work was to characterize the response of magnetic susceptibility differences in malignant brain tumors and surrounding edema to hyperoxic and hypercapnic respiratory challenges. METHODS: Images of malignant brain tumor patients (2 glioblastoma multiforme, 2 anaplastic astrocytoma, 1 brain metastasis) with clinical MRI exams (contrast-enhanced T1w) were acquired at 3T...
December 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29221918/low-variability-in-peak-expiratory-flow-predicts-successful-inhaled-corticosteroid-step-down-in-adults-with-asthma
#19
Naomi Tsurikisawa, Chiyako Oshikata, Toshio Sato, Goro Kimura, Masami Mizuki, Takahiro Tsuburai, Shunsuke Shoji, Hiroshi Saito, Terufumi Shimoda
BACKGROUND: The prognosis for patients beyond 1 year after reduction of their inhaled corticosteroid (ICS) dose remains unknown. Predictive factors that can be evaluated before the initiation of asthma treatment or at ICS dose reduction are unknown. METHODS: We prospectively studied 223 patients in 6 hospitals in the National Hospital Organization of Japan during the 36 months after 50% reduction of their daily ICS dose. All patients recorded their morning and evening peak expiratory flows (PEFs) in their diaries...
December 5, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29221728/emulsified-isoflurane-induces-release-of-cytochrome-c-in-human-neuroblastoma-shsy-5y-cells-via-jnk-c-jun-n-terminal-kinases-signaling-pathway
#20
Zeyong Yang, Jingjing Lv, Xianfu Lu, Xingxing Li, Xiaohu An, Jianwei Wang, Hao Weng, Yuanhai Li
A large number of studies have demonstrated that inhalation anesthetic isoflurane induced neural cell death by apoptosis in various cell and animal models. Emulsified isoflurane (EIso) is a new type of intravenous preparation of isoflurane that attracts increasing research attention as a promising clinical agent due to its both advantages as an intravenous and inhalation anesthetics medication. However, its safety and underlying molecular mechanism of neurotoxicity largely remain unknown. Therefore, it is meaningful to investigate the safety of EIso and to further elucidate its mechanism of anesthetic neurotoxicity...
December 5, 2017: Neurotoxicology and Teratology
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