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Francisco Jimenez, Antonia M Rojano-Delgado, Pablo Tomas Fernández, Cristina Rodríguez-Suárez, Sergio G Atienza, Rafael De Prado
The Clearfield(®) wheat cultivars possessing imidazolinone (IMI)-resistant traits provide an efficient option for controlling weeds. The imazamox-resistant cultivar Pantera (Clearfield(®) ) was compared with a susceptible cultivar (Gazul). Target and non-target mechanisms of resistance were studied to characterize the resistance of Pantera and to identify the importance of each mechanism involved in this resistance. Pantera is resistant to imazamox as was determined in previous experiments. The molecular study confirmed that it carries a mutation Ser-Asn627 conferring resistance to imazamox in two out of three acetolactate synthase (ALS) genes (imi1 and imi2), located in wheat on chromosomes 6B and 6D, respectively...
September 2016: Physiologia Plantarum
Sebastian G Ciancio, Adam D Marberger, Fadi Ayoub, Davis A Garlapo, Eugene A Pantera, Carole T Pantera, Sultan Al-Mubarak, Benita D Sobieraj, David Y He, Srinivas R Myneni
BACKGROUND: This double-masked, parallel-design, clinical trial assessed whether a combination nasal spray (K305; 3% tetracaine hydrochloride and 0.05% oxymetazoline hydrochloride) compared with a tetracaine-only spray and a placebo spray would be safer and superior in producing local anesthesia sufficient to complete a direct restorative procedure in maxillary nonmolar teeth. METHODS: The authors randomized eligible patients to receive K305 spray (n = 44), tetracaine hydrochloride spray (n = 44), or a placebo solution (n = 22)...
May 2016: Journal of the American Dental Association
E Pantera, C Pourtier-Piotte, L Bensoussan, E Coudeyre
OBJECTIVE: To perform a systematic review of the literature regarding amputee self-care, and analyze current experts' opinions. METHOD: The research in Medline and Cochrane Library databases was performed using the keywords "amputee self-care", "amputee health care", "amputee education", and "amputee health management". The methodological quality of the articles was assessed using four levels of evidence and three guideline grades (A: strong; B: moderate; C: poor)...
April 2014: Annals of Physical and Rehabilitation Medicine
Ralph Toelg, Béla Merkely, Andrejs Erglis, Stefan Hoffman, Huret Bruno, Ran Kornowski, Ton Slagboom, Christoph Naber, Bernhard Witzenbichler, Kristof Graf, Gert Richardt, Christoph Hehrlein
AIMS: Safety and efficacy of percutaneous coronary interventions using the Pantera Lux paclitaxel-coated balloon have been demonstrated in the PEPPER first-in-man trial. This prospective, multicentre, clinical registry aims to evaluate its safety and efficacy in an international real-world setting in a larger cohort of patients. METHODS AND RESULTS: Between April 2010 and April 2011, 1,064 patients were treated for predominantly diffuse and proliferative in-stent restenosis of bare metal stents (BMS-ISR) and drug-eluting stents (DES-ISR), or for de novo lesions...
September 2014: EuroIntervention
S G Ciancio, M C Hutcheson, F Ayoub, E A Pantera, C T Pantera, D A Garlapo, B D Sobieraj, S A Almubarak
This study examines the efficacy, safety, and tolerability of a nasal spray to induce anesthesia of maxillary teeth. Forty-five healthy adults requiring restoration of one maxillary tooth were randomized in a 1:2 ratio to receive (1) an intra-oral lidocaine-epinephrine injection with buffered saline nasal spray bilaterally, or (2) a tetracaine hydrochloride-oxymetazoline hydrochloride nasal spray bilaterally with sham injection. Primary endpoints were use of rescue anesthesia and patient global pain assessment...
July 2013: Journal of Dental Research
Peter J Moses, Daniel A Power, Amy M Jesionowski, Howard F Jenkinson, Eugene A Pantera, M Margaret Vickerman
INTRODUCTION: The surface-associated collagen-binding protein Ace of Enterococcus faecalis has been implicated as a virulence factor that contributes to bacterial persistence in endodontic infections. The purpose of this study was to determine if proteins with amino acid sequence similarity to Ace found in more abundant oral streptococci could play a similar role in potentially enhancing endodontic infections. METHODS: A Streptococcus gordonii gene similar to ace was identified by genome sequence searches in silico...
January 2013: Journal of Endodontics
Federica Martellini, Franco Faoro, Lara Carresi, Barbara Pantera, Ivan Baccelli, Dario Maffi, Bruno Tiribilli, Francesca Sbrana, Simone Luti, Cecilia Comparini, Rodolfo Bernardi, Gianni Cappugi, Aniello Scala, Luigia Pazzagli
Based on sequence homology, several fungal Cys-rich secreted proteins have been grouped in the cerato-platanin (CP) family, which comprises at least 40 proteins involved mainly in eliciting defense-related responses. The core member of this family is cerato-platanin, a moderately hydrophobic protein with a double ψ-β barrel fold. CP and the recently identified orthologous cerato-populin (Pop1) are involved in host-fungus interaction, and can be considered non-catalytic fungal PAMPs. CP is more active in inducing defense when in an aggregated conformation than in its native form, but little is known about other CP-orthologous proteins...
September 2013: Molecular Biotechnology
Michael Joner, Peter W Radke, Robert A Byrne, Sonja Hartwig, Kristin Steigerwald, Guy Leclerc, Eric Wittchow
Despite advances in contemporary stent technology, in-stent restenosis (ISR) remains the major limitation following revascularization procedures. We developed a porcine model of ISR to specifically investigate the preclinical outcomes of a novel drug-eluting balloon (DEB) in this particular setting. Fifteen pigs received bare metal stents in each of the major coronary arteries for 28 days to induce neointimal growth. Following repeat angiography, animals were allocated to fourdifferent treatment groups. The control group consisted of a bare angioplasty catheter, while the Pantera Lux™ (3...
February 2013: Journal of Biomaterials Applications
Christoph Hehrlein, Gert Richardt, Marcus Wiemer, Henrik Schneider, Christoph Naber, Ellen Hoffmann, Ulrich Dietz
AIMS: Drug-eluting balloons (DEB) have recently emerged as a valuable treatment option for patients with coronary in-stent restenosis (ISR). However, little information exists on results of DEB therapy of in-stent restenosis from drug-eluting stents (DES). METHODS AND RESULTS: The Pantera Lux balloon catheter, a novel DEB releasing paclitaxel with a BTHC matrix was studied in a prospective, multicentre first-in-man trial of patients with ISR either from bare metal stents (BMS) or drug-eluting stents (DES)...
May 2011: EuroIntervention
Aline L de Oliveira, Mariana Gallo, Luigia Pazzagli, Celso E Benedetti, Gianni Cappugi, Aniello Scala, Barbara Pantera, Alberto Spisni, Thelma A Pertinhez, Daniel O Cicero
Cerato-platanin (CP) is a secretion protein produced by the fungal pathogen Ceratocystis platani, the causal agent of the plane canker disease and the first member of the CP family. CP is considered a pathogen-associated molecular pattern because it induces various defense responses in the host, including production of phytoalexins and cell death. Although much is known about the properties of CP and related proteins as elicitors of plant defense mechanisms, its biochemical activity and host target(s) remain elusive...
May 20, 2011: Journal of Biological Chemistry
M Joner, R A Byrne, J-M Lapointe, P W Radke, G Bayer, K Steigerwald, E Wittchow
The advent of drug-eluting balloon (DEB) therapy has represented an important development in interventional cardiology. Nevertheless, preclinical data with this technology remain scant, and comparative studies have not previously been published. Bare metal stents were implanted in the coronary arteries of 15 pigs followed by balloon angioplasty. Animals were allocated to treatment with a 60-second inflation of one of four different balloon catheters: a conventional untreated plain angioplasty balloon (PBA, Biotronik AG), the Pantera Lux DEB (3...
May 2011: Thrombosis and Haemostasis
Gregory A Sgueglia, Daniel Todaro, Andrea Bisciglia, Micaela Conte, Antonino Stipo, Edoardo Pucci
OBJECTIVE: To assess the feasibility of kissing second-generation drug-eluting balloons (DEB), which have better mechanical properties than the first-generation DEB, in order to optimize provisional bare-metal stenting (BMS) when treating coronary bifurcation lesions in patients with contraindication to drug-eluting stents. METHODS: Consecutive patients with anticipated low compliance to dual antiplatelet therapy who are undergoing provisional stenting with an open-cell design BMS and final kissing balloon with second-generation DEB were enrolled in this feasibility study...
September 2011: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Paolo Paoli, Francesca Sbrana, Bruno Tiribilli, Anna Caselli, Barbara Pantera, Paolo Cirri, Alina De Donatis, Lucia Formigli, Daniele Nosi, Giampaolo Manao, Guido Camici, Giampietro Ramponi
Previous works reported that a mild increase in homocysteine level is a risk factor for cardiovascular and neurodegenerative diseases in humans. Homocysteine thiolactone is a cyclic thioester, most of which is produced by an error-editing function of methionyl-tRNA synthetase, causing in vivo post-translational protein modifications by reacting with the epsilon-amino group of lysine residues. In cells, the rate of homocysteine thiolactone synthesis is strictly dependent on the levels of the precursor metabolite, homocysteine...
July 23, 2010: Journal of Molecular Biology
Barbara Pantera, Chiara Bini, Paolo Cirri, Paolo Paoli, Guido Camici, Giampaolo Manao, Anna Caselli
Cellular prion protein (PrP(c)) is a ubiquitous glycoprotein, whose physiological role is poorly characterized. It has been suggested that PrP(c) participates in neuritogenesis, neuroprotection, copper metabolism, and signal transduction. In this study we detailed the intracellular events induced by PrP(c) antibody-mediated cross-linking in PC12 cells. We found a Fyn-dependent activation of the Ras-Raf pathway, which leads to a rapid and transient phosphorylation of extracellular regulated kinases. In addition, this activation cascade relies on the engagement of integrins, and involves focal adhesion kinase activation...
July 2009: Journal of Neurochemistry
Joseph D Bonavilla, Mary A Bush, Peter J Bush, Eugene A Pantera
With the increase in global terrorism there is a higher probability of having to identify victims of incineration events secondary to incendiary explosive devices. The victims of incineration events challenge forensic odontologists when coronal restorations are no longer present to compile postmortem data. With 40 million root canals being completed annually in the United States, a very large pool of antemortem data is available to the forensic odontologist to make positive identifications. When complete and thorough dental records exist, individuals that have undergone surgical and nonsurgical root canal therapy may have materials present in the canal that may aid in identification...
March 2008: Journal of Forensic Sciences
Lynn W Solomon, Eugene A Pantera, Edward Monaco, Stuart C White, Lakshmanan Suresh
Mandibular lingual bone depressions are considered to be developmental anomalies and most clinicians are familiar with the posterior variant (known as Stafne's bone cavity) that occurs in lingual mandibular molar regions, adjacent to the submandibular gland and below the mandibular canal. The anterior variant of the mandibular lingual bone depression is an asymptomatic bone cavity that occurs adjacent to the sublingual gland in the anterior mandible. Radiographically, it appears as a well-corticated radiolucency that retains a normal trabecular pattern internally...
September 2006: General Dentistry
Lara Carresi, Barbara Pantera, Camilla Zoppi, Gianni Cappugi, Aline L Oliveira, Thelma A Pertinhez, Alberto Spisni, Aniello Scala, Luigia Pazzagli
Cerato-platanin (CP) is a phytotoxic protein secreted by the Ascomycete Ceratocystis fimbriata f.sp. platani. This Ascomycete causes canker stain which is a severe disease with a high incidence in the European Platanus acerifolia. CP probably plays a role in the disease, eliciting defence-related responses in the host plants. CP is a 120 amino acid protein, containing 40% hydrophobic residues and two S-S bridges. In the EMBL data bank CP is the first member of a new fungal protein family known as the Cerato-Platanin Family...
October 2006: Protein Expression and Purification
Luigia Pazzagli, Barbara Pantera, Lara Carresi, Camilla Zoppi, Thelma A Pertinhez, Alberto Spisni, Stefania Tegli, Aniello Scala, Gianni Cappugi
The ascomycete Ceratocystis fimbriata, the causal agent of "canker stain disease," secretes a protein of 12.4 kDa that elicits phytoalexin synthesis and plant cell death. This protein, named cerato-platanin (CP), is also located in the cell walls of ascospores, hyphae, and conidia; it contains four cysteines (S-S bridged) and is moderately hydrophobic. The cp gene consists of a single exon and has 42 bp codifying for a signal peptide of 14 residues. The recombinant protein was obtained by cloning the cp gene of the mature protein in Escherichia coli (BL21), and a refolding step was needed to achieve the native active form...
2006: Cell Biochemistry and Biophysics
S Poienaru, N Sarpe, I Sarpe
In the latest years, sunflower was cultivated in Romania on an area of 800-900 thousand hectares. On 100 or 150 thousand hectares we find it cultivated also in agricultural farms in the Danube Meadow, because sunflower has favorable conditions on these soils, productions exceeding sometimes over 4000 kg/ha, of course, in irrigation conditions. In the Danube Meadow, the first experiments on Sorghum halepense (Johnson grass) species were performed by Fane Popa and colleagues (1986), at the agricultural station of Braila, using the herbicide Fusilade...
2005: Communications in Agricultural and Applied Biological Sciences
George S Lavenson, Richard L Pantera, Rosa M Garza, Tracey Neff, Sue D Rothwell, Jane Cisneros
BACKGROUND: Three medical conditions--cervical carotid artery disease, atrial fibrillation, and hypertension--cause the majority of strokes. Discovering these silent, immediate causes of stroke through screening, so they can be treated before stroke occurs, can potentially prevent strokes on an epidemiologic scale. METHODS: A rapid, accurate, and cost-effective stroke prevention screening (SPS) protocol was developed. RESULTS: The SPS protocol was used to screen 6,073 seniors residing in the central valley of California, at Madigan Army Medical Center, at New York University, and by the American Vascular Association at 68 leading institutions...
December 2004: American Journal of Surgery
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