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Misoprostol

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https://www.readbyqxmd.com/read/29233830/placental-abruption-leading-to-hysterectomy
#1
Hannah Catherine Sylvester, Madeleine Stringer
A 32-year-old multigravid patient at 21 weeks gestation presents with major concealed placental abruption and subsequent fetal demise. During an eventually failed misoprostol regime aiming for vaginal delivery she develops severe disseminated intravascular coagulopathy. Subsequent hysterotomy reveals Couvelaire uterus with major haemorrhage and requires subtotal hysterectomy for haemostasis. This case highlights the severity of the systemic response to abruption and fetal demise in utero and the multifactorial nature of its management...
December 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29215514/misoprostol-with-foley-bulb-compared-with-misoprostol-alone-for-cervical-ripening-a-randomized-controlled-trial
#2
Zainab Al-Ibraheemi, Lois Brustman, Brianne E Bimson, Natalie Porat, Barak Rosenn
OBJECTIVE: To test the hypothesis that cervical ripening using a combination of misoprostol and a transcervical Foley bulb leads to delivery within a shorter time compared with misoprostol alone. METHODS: This randomized controlled trial was offered to women admitted for cervical ripening. Inclusion criteria were gestational age 37 weeks or greater with intact membranes, singleton fetus, cephalic presentation, and Bishop score 6 or less. Exclusion criteria included, among others, prior uterine surgery, ruptured membranes, and any contraindication to vaginal delivery...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29200473/effect-of-premature-rupture-of-membranes-on-induction-of-labor-a-historical-cohort-study
#3
Sven Kehl, Christel Weiss, Ulf Dammer, Friederike Baier, Florian Faschingbauer, Matthias W Beckmann, Marc Sütterlin, Jutta Pretscher
Objective: The aim of this study was to assess the influence of premature rupture of membranes (PROM) on the induction of labor. Material and Method: This historical cohort study analyzed 1861 inductions of labor at term using misoprostol which occurred between 2010 and 2015. Exclusion criteria included intrauterine fetal death, previous cesarean section, and fetal structural or chromosomal anomalies. Induction of labor for PROM (PROM group) was compared to induction for other indications (no-PROM group); the primary outcome measure was the cesarean section rate...
November 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29196154/labour-induction-practices-in-france-a-population-based-declarative-survey-in-94-maternity-units
#4
P Blanc-Petitjean, M Salomé, C Dupont, C Crenn-Hebert, A Gaudineau, F Perrotte, P Raynal, E Clouqueur, G Beucher, B Carbonne, F Goffinet, C Le Ray
INTRODUCTION: In 2010, 22.7% of deliveries in France were induced. The current lack of high level of evidence data about the methods and indications for induction of labour has promoted heterogeneous and non-recommended practices. The extent of these different practices is not adequately known in France today, although they may influence perinatal outcomes. The objective of this study was to report current practices of induction of labour in France. MATERIAL AND METHODS: This study surveyed 94 maternity units in seven perinatal networks...
November 28, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29175274/provision-of-menstrual-regulation-with-medication-among-pharmacies-in-three-municipal-districts-of-bangladesh-a-situation-analysis
#5
Fauzia Akhter Huda, Hassan Rushekh Mahmood, Anadil Alam, Faisal Ahmmed, Farzana Karim, Bidhan Krishna Sarker, Nafis Al Haque, Anisuddin Ahmed
OBJECTIVE: To assess the provision of the combination of mifepristone-misoprostol for menstrual regulation (MR) in randomly selected urban pharmacies in Bangladesh. STUDY DESIGN: We conducted a cross-sectional survey among 553 pharmacy workers followed by 548 mystery client visits to the same pharmacies in three municipal districts during July 2014-December 2015. RESULTS: The survey found that 99% of pharmacy workers visited had knowledge of MR procedures but only two-thirds (67%) could state the legal time limit correctly; they mentioned misoprostol (86%) over mifepristone-misoprostol combination (78%) as a procedure of MR with medication (MRM); 36% reported knowing the recommended dosage of mifepristone-misoprostol combination; 70% reported providing information on effectiveness of the medicines; 50% reported recommending at least one follow-up visit to them; 63% reported explaining possible complications of using the medications; and 47% reported offering any post-MR contraception to their clients...
November 22, 2017: Contraception
https://www.readbyqxmd.com/read/29173181/misoprostol-induced-acute-coronary-syndrome-in-a-premenopausal-woman-a-case-report-with-literature-review
#6
Faizan Mazhar, Jabeen Sultana, Shahzad Akram
Misoprostol is a synthetic analog of prostaglandin-E1 and it is most widely used drug for the medical management of incomplete abortion. Acute coronary syndrome (ACS) rarely occurs in perimenopausal women, in addition, the presentation is atypical, so the disease is not always recognized. We describe a case of 39-year-old woman with no major underlying cardiovascular risk factors, who developed an episode of ACS following the administration of two doses of misoprostol. After the discontinuation of misoprostol treatment, there was a complete resolution of patient's symptoms...
November 21, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/29170088/simplified-medical-abortion-screening-a-demonstration-project
#7
Elizabeth G Raymond, Yi-Ling Tan, Rodica Comendant, Irina Sagaidac, Stelian Hodorogea, Melissa Grant, Patricio Sanhueza, Emigdio Van Pratt, Ginger Gillespie, Christy Boraas, Mark A Weaver, Ingrida Platais, Manuel Bousieguez, Beverly Winikoff
OBJECTIVES: To evaluate the safety and acceptability of outpatient medical abortion in selected women without a pretreatment ultrasound or pelvic examination. STUDY DESIGN: We conducted a prospective case-series study to estimate the incidence of serious adverse events (death, life-threatening event, hospitalization, transfusion, or any other medical problem that we judged to be significant), surgical completion of the abortion, and satisfaction in women provided with medical abortion without a pretreatment ultrasound or pelvic examination...
November 20, 2017: Contraception
https://www.readbyqxmd.com/read/29168561/combination-therapy-with-mifepristone-and-misoprostol-for-the-management-of-first-trimester-miscarriage-improved-success
#8
Angela Dunford, Rina Fyfe
BACKGROUND: First trimester miscarriage affects 20% of pregnancies. Medical management has a high degree of patient acceptance and does not increase the risk of infection. Mifepristone is an anti-progesterone shown to improve outcomes when used in conjunction with misoprostol for first trimester abortion. However, there have been conflicting results when it has been added to treatment regimens for miscarriage. METHODS: We performed a retrospective cohort analysis of women presenting to the Acute Gynaecology Service of our tertiary referral centre for miscarriage management from December 2010 until December 2013...
November 23, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29154779/letrozole-pre-treatment-prior-to-medical-termination-of-pregnancy-a-systematic-review
#9
Christopher M Nash, Lauren Philp, Prakesh Shah, Kellie E Murphy
OBJECTIVE(S): The purpose of this systematic review was to evaluate the efficacy of pretreatment with letrozole prior to either a first or second trimester medical termination of pregnancy. STUDY DESIGN: We searched letrozole, femara, aromatase inhibitors, abortifacient agents, termination of pregnancy, and labour induction in MEDLINE, EMBASE, Cochrane Database, Google Scholar, and PubMed from inception of each database until September 2015 with no language limitation...
November 14, 2017: Contraception
https://www.readbyqxmd.com/read/29153318/misoprostol-drug-to-be-withdrawn-from-french-market
#10
Barbara Casassus
No abstract text is available yet for this article.
November 16, 2017: Lancet
https://www.readbyqxmd.com/read/29153317/retraction-and-republication-misoprostol-drug-to-be-withdrawn-from-french-market
#11
The Editors Of The Lancet
No abstract text is available yet for this article.
November 16, 2017: Lancet
https://www.readbyqxmd.com/read/29138519/time-to-delivery-and-delivery-outcomes-comparing-three-methods-of-labor-induction-in-7551-nulliparous-women-a-population-based-cohort-study
#12
C Lindblad Wollmann, M Ahlberg, G Petersson, S Saltvedt, O Stephansson
OBJECTIVE: Determine time-to-delivery and mode-of-delivery in labor induction among women with unripe cervix. STUDY DESIGN: 7551 nulliparous women with singleton deliveries, ⩾37 weeks, Bishop Score ⩽6, induced with dinoprostone, misoprostol or transcervical single balloon catheter. Linear regression analysis was used to estimate mean time-to-delivery with β-estimates and 95% confidence intervals with adjustments. Multivariable logistic regression analysis was used to calculate odds of cesarean delivery, instrumental vaginal delivery, maternal and neonatal outcomes...
November 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29133110/provision-of-medical-abortion-by-mid-level-healthcare-providers-in-kyrgyzstan-testing-an-intervention-to-expand-safe-abortion-services-to-under-served-rural-and-peri-urban-areas
#13
Brooke Ronald Johnson, Elmira Maksutova, Aigull Boobekova, Ainura Davletova, Chinara Kazakbaeva, Yelena Kondrateva, Sihem Landoulsi, Gunta Lazdane, Kubanychbek Monolbaev, Armando H Seuc Jo
OBJECTIVE: To demonstrate the feasibility and safety of training mid-level healthcare providers (midwives and family nurses) to provide medical abortion and post-abortion contraception in under-served areas in Kyrgyzstan. STUDY DESIGN: This was an implementation study at four referral facilities and 28 Felsher Obstetric Points in two districts to train their midwives and family nurses to deliver safe and effective abortion care with co-packaged mifepristone-misoprostol and provide contraceptives post-abortion...
November 10, 2017: Contraception
https://www.readbyqxmd.com/read/29124067/labor-induction-with-orally-administrated-misoprostol-a-retrospective-cohort-study
#14
Tove Wallstrom, Hans Jarnbert-Pettersson, David Stenson, Helena Akerud, Elisabeth Darj, Kristina Gemzell-Danielsson, Eva Wiberg-Itzel
Introduction: One great challenge in obstetric care is labor inductions. Misoprostol has advantages in being cheap and stable at room temperature and available in resource-poor settings. Material and Methods: Retrospective cohort study of 4002 singleton pregnancies with a gestational age ≥34 w at Sodersjukhuset, Stockholm, during 2009-2010 and 2012-2013. Previously used methods of labor induction were compared with misoprostol given as a solution to drink, every second hour...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29122709/evaluation-of-effect-of-letrozole-prior-to-misoprostol-in-comparison-with-misoprostol-alone-in-success-rate-of-induced-abortion
#15
Somayeh Derakhshan-Aydenloo, Tahereh Behroozi-Lak, Farzaneh Broomand
BACKGROUND: Abortion, spontaneous or induced, is a common complication of pregnancy and exploration of available and safe regimens for medical abortion in developing countries seems crucial. AIMS: The present study was aimed to assess the effect of letrozole in combination with misoprostol in women eligible for legal therapeutic abortion with gestational age ≤14weeks. MATERIALS AND METHODS: This clinical randomized trial was conducted on 78 women who were candidate of medical abortion and eligible for legal abortion with gestational age ≤14 weeks that were randomly divided into two groups of case and controls...
November 6, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29115228/misoprostol-drug-to-be-withdrawn-from-french-market
#16
Barbara Casassus
No abstract text is available yet for this article.
October 28, 2017: Lancet
https://www.readbyqxmd.com/read/29105381/early-gestational-hypoxia-and-adverse-developmental-outcomes
#17
REVIEW
Helen E Ritchie, Diana J Oakes, Debra Kennedy, Jaimie W Polson
Hypoxia is a normal and essential part of embryonic development. However, this state may leave the embryo vulnerable to damage when oxygen supply is disturbed. Embryofetal response to hypoxia is dependent on duration and depth of hypoxia, as well as developmental stage. Early postimplantation rat embryos were resilient to hypoxia, with many surviving up to 1.5 hr of uterine clamping, while most mid-gestation embryos were dead after 1 hour of clamping. Survivors were small and many had a range of defects, principally terminal transverse limb reduction defects...
October 16, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29104024/abortion-in-two-francophone-african-countries-a-study-of-whether-women-have-begun-to-use-misoprostol-in-benin-and-burkina-faso
#18
Carine Baxerres, Ines Boko, Adjara Konkobo, Fatoumata Ouattara, Agnès Guillaume
OBJECTIVES: This study aimed to document the means women use to obtain abortions in the capital cities of Benin and Burkina Faso, and to learn whether or not use of misoprostol has become an alternative to other methods of abortion, and the implications for future practice. STUDY DESIGN: We conducted in-depth, qualitative interviews between 2014 and 2015 with 34 women - 21 women in Cotonou (Benin) and 13 women in Ouagadougou (Burkina Faso) - about their pathways to abortion...
November 3, 2017: Contraception
https://www.readbyqxmd.com/read/29094502/association-between-uterine-position-and-transvaginal-misoprostol-treatment-for-early-pregnancy-failure
#19
Henry H Chill, Nirit Malyanker, Gilad Karavani, Rani Haj-Yahya, Shmuel Herzberg, Raz Bahar, David Shveiky, Uri P Dior
AIM: We aimed to determine the importance of uterine position as a predicting factor of success rate in medically treated early pregnancy failure (EPF). METHODS: We carried out a retrospective cohort study at the Obstetrics and Gynecology Department of a tertiary medical center between January 2011 and June 2012. We included women diagnosed with EPF, which we defined as women diagnosed with missed abortion up to 13 gestational weeks. Patients were treated with one or two doses of 800 μg of misoprostol vaginally in accordance with the department's protocol...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29078777/barriers-or-gaps-in-implementation-of-misoprostol-use-for-post-abortion-care-and-post-partum-hemorrhage-prevention-in-developing-countries-a-systematic-review
#20
REVIEW
Amir Ali Barket Ali Samnani, Narjis Rizvi, Tazeen Saeed Ali, Farina Abrejo
BACKGROUND: Around 303,000 maternal deaths occur every year; most of these are preventable (World Health Organization), ICD-10: International classification of diseases and related health problems, 10th revision. Volume 2: Instruction manual, 2010). Ninety-nine percent of these maternal deaths occur in developing countries. PPH contributed 35 % (35%) of total maternal. Several interventions being done to reduce the number of maternal deaths. It has been noted that a simple low cost intervention of providing misoprostol timely could prevent these deaths...
October 27, 2017: Reproductive Health
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