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Misoprostol

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https://www.readbyqxmd.com/read/28209537/misorest-surgical-versus-expectant-management-in-women-with-an-incomplete-evacuation-of-the-uterus-after-misoprostol-treatment-for-miscarriage-a-cohort-study
#1
Marike Lemmers, Marianne A C Verschoor, Katrien Oude Rengerink, Christiana Naaktgeboren, Patrick M Bossuyt, Judith A F Huirne, Ineke A H Janssen, Celine Radder, Ellen R Klinkert, Josje Langenveld, Lucet van der Voet, F Frederike Siemens, Marlies Y Bongers, Marcel H van Hooff, Marinus van der Ploeg, F P J Sjors, S F P J Coppus, W M Ankum, Ben Willem J Mol
OBJECTIVE: To assess the effectiveness of curettage versus expectant management in women with an incomplete evacuation of the uterus after misoprostol treatment for first trimester miscarriage. STUDY DESIGN: We conducted a multicenter cohort study alongside a randomized clinical trial (RCT) between June 2012 until July 2014. 27 Dutch hospitals participated. Women with an incomplete evacuation after misoprostol treatment for first trimester miscarriage who declined to participate in the RCT, received treatment of their preference; curettage (n=65) or expectant management (n=132)...
January 27, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28209173/moving-from-legality-to-reality-how-medical-abortion-methods-were-introduced-with-implementation-science-in-zambia
#2
Tamara Fetters, Ghazaleh Samandari, Patrick Djemo, Bellington Vwallika, Stephen Mupeta
BACKGROUND: Although abortion is technically legal in Zambia, the reality is far more complicated. This study describes the process and results of galvanizing access to medical abortion where abortion has been legal for many years, but provision severely limited. It highlights the challenges and successes of scaling up abortion care using implementation science to document 2 years of implementation. METHODS: An intervention between the Ministry of Health, University Teaching Hospital and the international organization Ipas, was established to introduce medical abortion and to address the lack of understanding and implementation of the country's abortion law...
February 16, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28204882/comparison-between-vaginal-and-sublingual-misoprostol-50%C3%A2-%C3%A2%C2%B5g-for-cervical-ripening-prior-to-induction-of-labor-randomized-clinical-trial
#3
Andrés Conde, Sebastián Ben, Josefina Tarigo, Santiago Artucio, Virginia Varela, Pamela Grimaldi, Claudio Sosa, Justo Alonso
OBJECTIVE: To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6 h of administration. METHODS: Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. Bishop score was assessed at the time of induction and 6 h after administration of 50 µg misoprostol. Analysis was made over difference in mean Bishop score of 2 points, using a standard deviation of 2, with 90% power, reaching a 95% confidence interval...
February 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28199872/fertility-and-obstetric-outcomes-after-curettage-versus-expectant-management-in-randomised-and-non-randomised-women-with-an-incomplete-evacuation-of-the-uterus-after-misoprostol-treatment-for-miscarriage
#4
M Lemmers, M A C Verschoor, K Overwater, P M Bossuyt, D Hendriks, M Hemelaar, J M Schutte, A H Adriaanse, W M Ankum, J A F Huirne, B W J Mol
OBJECTIVE: To assess fertility and obstetric outcomes in women treated with curettage or undergoing expectant management for an incomplete miscarriage after misoprostol treatment. STUDY DESIGN: Between June 2012 and July 2014, we conducted a multicentre randomised clinical trial (RCT) with a parallel cohort study for non-randomised women, treated according to their preference. In the RCT 30 women were allocated curettage and 29 expectant management. In the cohort 197 women participated; 65 underwent curettage and 132 women underwent expectant management...
January 30, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28192275/first-trimester-medical-abortion-practices-in-canada-national-survey
#5
Edith R Guilbert, Althea S Hayden, Heidi E Jones, Katharine O'Connell White, E Steven Lichtenberg, Maureen Paul, Wendy V Norman
OBJECTIVE: To understand the current availability and practice of first-trimester medical abortion (MA) in Canada. DESIGN: Using public sources and professional networks, abortion facilities across Canada were identified for a cross-sectional survey on medical and surgical abortion. English and French surveys were distributed by surface or electronic mail between July and November 2013. SETTING: Canada. PARTICIPANTS: A total of 94 abortion facilities were identified...
April 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28188146/abortion-and-fertility-control-in-pakistan-the-role-of-misoprostol
#6
Harneet Chahal, Zubia Mumtaz
OBJECTIVE: To examine how availability of misoprostol has impacted women's abortion-seeking behaviour in Pakistan. DESIGN: Focused ethnography. SETTING: A facility providing reproductive health services, including induced abortions in Chakwal, a small town in Northern Punjab, Pakistan. POPULATION: Women who came to the clinic seeking an abortion or who had had one in the last 6 months (n=23) and all healthcare providers working in the facility (n=14)...
February 10, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28164737/anti-helicobacter-pylori-and-antiulcerogenic-activity-of-aframomum-pruinosum-seeds-on-indomethacin-induced-gastric-ulcer-in-rats
#7
Laure Brigitte Kouitcheu Mabeku, Blandine Nanfack Nana, Bertrand Eyoum Bille, Roland Tchuenteu Tchuenguem, Eveline Nguepi
CONTEXT: Peptic ulcer is one of the most common diseases affecting mankind. Although there are many products used for its treatment, most of these products produce severe adverse reactions requiring the search for novel compounds. Some Afromomum species are used traditionally to cure acute gastritis. OBJECTIVE: To evaluate the antiulcer activity of the methanol extract of Aframomum pruinosum Gagnepain (Zingiberaceae) seeds against two major etiologic agents of peptic ulcer disease; Helicobacter pylori and non-steroidal anti-inflammatory drugs...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28138973/medical-treatments-for-incomplete-miscarriage
#8
REVIEW
Caron Kim, Sharmani Barnard, James P Neilson, Martha Hickey, Juan C Vazquez, Lixia Dou
BACKGROUND: Miscarriage occurs in 10% to 15% of pregnancies. The traditional treatment, after miscarriage, has been to perform surgery to remove any remaining placental tissues in the uterus ('evacuation of uterus'). However, medical treatments, or expectant care (no treatment), may also be effective, safe, and acceptable. OBJECTIVES: To assess the effectiveness, safety, and acceptability of any medical treatment for incomplete miscarriage (before 24 weeks). SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (13 May 2016) and reference lists of retrieved papers...
January 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28125096/diabetes-mellitus-an-independent-predictor-of-duration-of-prostaglandin-labor-induction
#9
J S Hawkins, M Stephenson, B Powers, D A Wing
OBJECTIVE: The objective of this study is to analyze the association of diabetes mellitus with progress and outcomes of prostaglandin (PG) labor induction using a retrievable vaginal insert. STUDY DESIGN: This is a secondary analysis of data collected during the Misoprostol Vaginal Insert Trial (Miso-Obs-004), a multicenter, double-blind, randomized controlled trial of women undergoing induction of labor with PGs. The duration, characteristics and outcomes of labor were compared in women with and without diabetes...
January 26, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28109045/misoprostol-for-cervical-priming-prior-to-hysteroscopy-in-postmenopausal-and-premenopausal-nulliparous-women-a-multicentre-randomised-placebo-controlled-trial
#10
M L Tasma, M Louwerse, W J Hehenkamp, P M Geomini, M Y Bongers, S Veersema, P J van Kesteren, E Tromp, J A Huirne, G C Graziosi
OBJECTIVE: To evaluate the reduction of pain by Misoprostol compared to placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. DESIGN: Randomised multicentre double-blind placebo controlled trial. SETTING: Two Dutch teaching hospitals and one Dutch university medical centre. POPULATION: Postmenopausal and premenopausal nulliparous women undergoing office hysteroscopy. METHODS: Patients were randomised to receive either 400 mcg Misoprostol or placebo 12 and 24 hours before hysteroscopy...
January 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28099741/abortion-choices-among-women-in-cambodia-after-introduction-of-a-socially-marketed-medicated-abortion-product
#11
Khim Sotheary, Dianna Long, Gary Mundy, Yasmin Madan, Paul D Blumenthal
OBJECTIVE: To assess whether a social marketing initiative focusing on medicated abortion via a mifepristone/misoprostol "combipack" has contributed to reducing unsafe abortion in Cambodia. METHODS: In a questionnaire-based cross-sectional study, annual household surveys were conducted across 13 Cambodian provinces in 2010, 2011, and 2012. One married woman of reproductive age who was not pregnant and did not wish to be within the next 2 years in each randomly selected household was approached for inclusion...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099731/provision-of-harm-reduction-services-to-limit-unsafe-abortion-in-tanzania
#12
Catherine Kahabuka, Andrea Pembe, Alejandra Meglioli
OBJECTIVE: To investigate the feasibility of providing harm-reduction services to reduce unsafe abortion in Tanzania. METHODS: A cross-sectional study was conducted among 110 women who received harm-reduction counseling at a public health center in Dar es Salaam between February 10 and October 10, 2014. Background and clinical information was collected for all women; a subgroup (n=50) undertook a semi-structured survey that measured the type of services women received, women's perception of the services, and pregnancy outcome...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099728/effects-of-an-intervention-initiated-by-a-national-society-to-improve-postabortion-care-in-rural-facilities-in-burkina-faso
#13
Sibraogo Kiemtoré, Hyacinthe Zamané, Danlotoma P Kaïn, Yobi A Sawadogo, Issa Ouédraogo, Ali Ouédraogo, Jean Lankoandé
OBJECTIVE: To evaluate the results of an intervention by the Societé de Gynécologues et Obstétriciens du Burkina (SOGOB) to improve postabortion care (PAC) in rural areas of Burkina Faso. METHODS: From June 1, 2012, to May 31, 2013, SOGOB increased capacity for PAC by providing training in health care and equipment to 45 rural health facilities. Performance in PAC in the year before intervention (June 1, 2011, to May 31, 2012) was compared with that in the year following intervention (June 1, 2013, to May 31, 2014)...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28088498/vaginal-misoprostol-prior-to-intrauterine-device-insertion-in-women-delivered-only-by-elective-cesarean-section-a-randomized-double-blind-clinical-trial
#14
Mohamed S Abdellah, Ahmed M Abbas, Aml M Hegazy, Ihab M El-Nashar
OBJECTIVE: The current study aims to evaluate if vaginal misoprostol (400 mcg) administered prior to intrauterine device (IUD) insertion increases the ease and success of insertion among women who had delivered only by elective cesarean delivery (CD). STUDY DESIGN: The current study was a randomized, double-blind, placebo-controlled trial conducted in Assiut Women's Health Hospital, Egypt, between the 1st of April 2015 and the 31st of March 2016 and included women who delivered only by elective CD...
January 11, 2017: Contraception
https://www.readbyqxmd.com/read/28076696/proton-pump-inhibitors-for-preventing-non-steroidal-anti-inflammatory-drug-induced-gastrointestinal-toxicity-a-systematic-review
#15
Man Yang, Min He, Miao Zhao, Bing Zou, Jun Liu, Ling-Min Luo, Qiu-Lan Li, Jun-Hui He, Ping-Guang Lei
OBJECTIVE: Proton pump inhibitors (PPIs) are recommended for preventing gastrointestinal lesions induced by non-steroidal anti-inflammatory drugs (NSAIDs). We performed this study: (1) to evaluate the effectiveness and safety of PPIs, (2) to explore the association between effectiveness and potential influential factors, and (3) to investigate the comparative effect of different PPIs. METHODS: MEDLINE, EMBASE, and the Cochrane Library were searched to identify randomized controlled trials comparing different classes of PPIs, or comparing PPIs with placebo, H2 receptor antagonists or misoprostol in NSAIDs users...
January 25, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28069480/different-routes-of-misoprostol-for-same-day-cervical-priming-prior-to-operative-hysteroscopy-a-randomized-blind-trial
#16
Hadas Ganer Herman, Ram Kerner, Ohad Gluk, Hagit Feit, Ran Keidar, Jacob Bar, Ron Sagiv
STUDY OBJECTIVE: To compare the effectiveness and patient satisfaction of different routes of misoprostol for short term cervical priming prior to operative hysteroscopy. DESIGN: randomized blind trial DESIGN: classification: Canadian Task Force classification I SETTING: University hospital PATIENTS: 120 patients undergoing operative hysteroscopy. INTERVENTIONS: Patients were randomly assigned to receive 400 μg misoprostol administered orally (n=40), vaginally (n=40) and sub-lingual (n=40) for cervical priming 1...
January 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28056879/association-between-infection-and-fever-in-terminations-of-pregnancy-using-misoprostol-a-retrospective-cohort-study
#17
Tobias A J Nijman, Kevin G J A Voogdt, Pim W Teunissen, Patrick J Jp van der Voorn, Christianne J M de Groot, Petra C A M Bakker
BACKGROUND: Fever is a well-known side effect of misoprostol, but clinically difficult to distinguish from an intra uterine infection. The aim of this study was to determine the incidence of fever in terminations of pregnancy (TOP) using misoprostol and to evaluate fever as indication of intra uterine infection. METHODS: A retrospective cohort study was performed. Consecutive second trimester TOP with misoprostol between January 2008 and October 2012 were selected...
January 5, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28050900/planned-early-birth-versus-expectant-management-waiting-for-prelabour-rupture-of-membranes-at-term-37-weeks-or-more
#18
REVIEW
Philippa Middleton, Emily Shepherd, Vicki Flenady, Rosemary D McBain, Caroline A Crowther
BACKGROUND: Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES: The objective of this review is to assess the effects of planned early birth (immediate intervention or intervention within 24 hours) when compared with expectant management (no planned intervention within 24 hours) for women with term PROM on maternal, fetal and neonatal outcomes...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28040121/sublingual-misoprostol-versus-intravenous-oxytocin-in-reducing-bleeding-during-and-after-cesarean-delivery-a-randomized-clinical-trial
#19
Essam Rashad Othman, Margaret Fathy Fayez, Diaa Eldeen Mohamed Abd El Aal, Hazem Saad El-Dine Mohamed, Ahmed Mohammed Abbas, Mohammed Khairy Ali
OBJECTIVE: This study compares the efficacy of sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery. MATERIALS AND METHODS: A randomized clinical trial conducted on 120 pregnant women at term (37-40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either sublingual misoprostol 400 μg or intravenous infusion of 20 units of oxytocin after delivery of the neonate. The main outcome measures were blood loss at and 2 hours after cesarean delivery, change in hematocrit value, need for any additional oxytocic drugs, and drug-related side effects...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28031316/implementing-medical-abortion-with-mifepristone-and-misoprostol-in-norway-1998-2013
#20
Mette Løkeland, Tone Bjørge, Ole-Erik Iversen, Rupali Akerkar, Line Bjørge
BACKGROUND: Medical abortion with mifepristone and misoprostol was introduced in Norway in 1998, and since then there has been an almost complete change from predominantly surgical to medical abortions. We aimed to describe the medical abortion implementation process, and to compare characteristics of women obtaining medical and surgical abortion. METHODS: Information from all departments of obstetrics and gynaecology in Norway on the time of implementation of medical abortion and abortion procedures in use up to 12 weeks of gestation was assessed by surveys in 2008 and 2012...
December 28, 2016: International Journal of Epidemiology
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