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Misoprostol

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https://www.readbyqxmd.com/read/28099741/abortion-choices-among-women-in-cambodia-after-introduction-of-a-socially-marketed-medicated-abortion-product
#1
Khim Sotheary, Dianna Long, Gary Mundy, Yasmin Madan, Paul D Blumenthal
OBJECTIVE: To assess whether a social marketing initiative focusing on medicated abortion via a mifepristone/misoprostol "combipack" has contributed to reducing unsafe abortion in Cambodia. METHODS: In a questionnaire-based cross-sectional study, annual household surveys were conducted across 13 Cambodian provinces in 2010, 2011, and 2012. One married woman of reproductive age who was not pregnant and did not wish to be within the next 2 years in each randomly selected household was approached for inclusion...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099731/provision-of-harm-reduction-services-to-limit-unsafe-abortion-in-tanzania
#2
Catherine Kahabuka, Andrea Pembe, Alejandra Meglioli
OBJECTIVE: To investigate the feasibility of providing harm-reduction services to reduce unsafe abortion in Tanzania. METHODS: A cross-sectional study was conducted among 110 women who received harm-reduction counseling at a public health center in Dar es Salaam between February 10 and October 10, 2014. Background and clinical information was collected for all women; a subgroup (n=50) undertook a semi-structured survey that measured the type of services women received, women's perception of the services, and pregnancy outcome...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099728/effects-of-an-intervention-initiated-by-a-national-society-to-improve-postabortion-care-in-rural-facilities-in-burkina-faso
#3
Sibraogo Kiemtoré, Hyacinthe Zamané, Danlotoma P Kaïn, Yobi A Sawadogo, Issa Ouédraogo, Ali Ouédraogo, Jean Lankoandé
OBJECTIVE: To evaluate the results of an intervention by the Societé de Gynécologues et Obstétriciens du Burkina (SOGOB) to improve postabortion care (PAC) in rural areas of Burkina Faso. METHODS: From June 1, 2012, to May 31, 2013, SOGOB increased capacity for PAC by providing training in health care and equipment to 45 rural health facilities. Performance in PAC in the year before intervention (June 1, 2011, to May 31, 2012) was compared with that in the year following intervention (June 1, 2013, to May 31, 2014)...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28088498/vaginal-misoprostol-prior-to-intrauterine-device-insertion-in-women-delivered-only-by-elective-cesarean-section-a-randomized-double-blind-clinical-trial
#4
Mohamed S Abdellah, Ahmed M Abbas, Aml M Hegazy, Ihab M El-Nashar
OBJECTIVE: The current study aims to evaluate if vaginal misoprostol (400 mcg) administered prior to intrauterine device (IUD) insertion increase the ease and success of insertion among women who had delivered only by elective Cesarean delivery (CD). STUDY DESIGN: The current study was a randomized, double-blind, placebo-controlled trial, conducted in Assiut Women's Health Hospital, Egypt between the 1st of April 2015 and the 31st of March 2016 included women delivered only by elective CD...
January 11, 2017: Contraception
https://www.readbyqxmd.com/read/28076696/proton-pump-inhibitors-for-preventing-non-steroidal-anti-inflammatory-drug-induced-gastrointestinal-toxicity-a-systematic-review
#5
Man Yang, Min He, Miao Zhao, Bing Zou, Jun Liu, Ling-Min Luo, Qiu-Lan Li, Jun-Hui He, Ping-Guang Lei
OBJECTIVE: Proton pump inhibitors (PPIs) are recommended for preventing gastrointestinal lesions induced by non-steroidal anti-inflammatory drug (NSAID). We performed this study (1) to evaluate the effectiveness and safety of PPIs, (2) to explore the association between effectiveness and potential influential factors, and (3) to investigate the comparative effect of different PPIs. METHODS: MEDLINE, EMBASE, and the Cochrane Library were searched to identify randomized controlled trials comparing different classes of PPIs, or comparing PPIs with placebo, H2 receptor antagonists or misoprostol in NSAIDs users...
January 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28069480/different-routes-of-misoprostol-for-same-day-cervical-priming-prior-to-operative-hysteroscopy-a-randomized-blind-trial
#6
Hadas Ganer Herman, Ram Kerner, Ohad Gluk, Hagit Feit, Ran Keidar, Jacob Bar, Ron Sagiv
STUDY OBJECTIVE: To compare the effectiveness and patient satisfaction of different routes of misoprostol for short term cervical priming prior to operative hysteroscopy. DESIGN: randomized blind trial DESIGN: classification: Canadian Task Force classification I SETTING: University hospital PATIENTS: 120 patients undergoing operative hysteroscopy. INTERVENTIONS: Patients were randomly assigned to receive 400 μg misoprostol administered orally (n=40), vaginally (n=40) and sub-lingual (n=40) for cervical priming 1...
January 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28056879/association-between-infection-and-fever-in-terminations-of-pregnancy-using-misoprostol-a-retrospective-cohort-study
#7
Tobias A J Nijman, Kevin G J A Voogdt, Pim W Teunissen, Patrick J Jp van der Voorn, Christianne J M de Groot, Petra C A M Bakker
BACKGROUND: Fever is a well-known side effect of misoprostol, but clinically difficult to distinguish from an intra uterine infection. The aim of this study was to determine the incidence of fever in terminations of pregnancy (TOP) using misoprostol and to evaluate fever as indication of intra uterine infection. METHODS: A retrospective cohort study was performed. Consecutive second trimester TOP with misoprostol between January 2008 and October 2012 were selected...
January 5, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28050900/planned-early-birth-versus-expectant-management-waiting-for-prelabour-rupture-of-membranes-at-term-37-weeks-or-more
#8
REVIEW
Philippa Middleton, Emily Shepherd, Vicki Flenady, Rosemary D McBain, Caroline A Crowther
BACKGROUND: Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES: The objective of this review is to assess the effects of planned early birth (immediate intervention or intervention within 24 hours) when compared with expectant management (no planned intervention within 24 hours) for women with term PROM on maternal, fetal and neonatal outcomes...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28040121/sublingual-misoprostol-versus-intravenous-oxytocin-in-reducing-bleeding-during-and-after-cesarean-delivery-a-randomized-clinical-trial
#9
Essam Rashad Othman, Margaret Fathy Fayez, Diaa Eldeen Mohamed Abd El Aal, Hazem Saad El-Dine Mohamed, Ahmed Mohammed Abbas, Mohammed Khairy Ali
OBJECTIVE: This study compares the efficacy of sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery. MATERIALS AND METHODS: A randomized clinical trial conducted on 120 pregnant women at term (37-40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either sublingual misoprostol 400 μg or intravenous infusion of 20 units of oxytocin after delivery of the neonate. The main outcome measures were blood loss at and 2 hours after cesarean delivery, change in hematocrit value, need for any additional oxytocic drugs, and drug-related side effects...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28031316/implementing-medical-abortion-with-mifepristone-and-misoprostol-in-norway-1998-2013
#10
Mette Løkeland, Tone Bjørge, Ole-Erik Iversen, Rupali Akerkar, Line Bjørge
BACKGROUND: Medical abortion with mifepristone and misoprostol was introduced in Norway in 1998, and since then there has been an almost complete change from predominantly surgical to medical abortions. We aimed to describe the medical abortion implementation process, and to compare characteristics of women obtaining medical and surgical abortion. METHODS: Information from all departments of obstetrics and gynaecology in Norway on the time of implementation of medical abortion and abortion procedures in use up to 12 weeks of gestation was assessed by surveys in 2008 and 2012...
December 28, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27986461/randomized-clinical-trial-between-hourly-titrated-and-2-hourly-static-oral-misoprostol-solution-for-induction-of-labor
#11
Abdulrahim A Rouzi, Nora Alsahly, Rana Alamoudi, Nisma Almansouri, Nawal Alsinani, Souzan Alkafy, Rayyan Rozzah, Hassan Abduljabbar
BACKGROUND: Misoprostol is an effective agent for the induction of labor. Existing guidelines recommend oral misoprostol solution 25 μg every 2 hours. However, more research is required to optimize the use of oral misoprostol solution for the induction of labor. OBJECTIVE: The purpose of this study was to compare efficacy and safety of hourly titrated-dose oral misoprostol solution with static-dose oral misoprostol solution every 2 hours for labor induction. STUDY DESIGN: In this randomized controlled study, oral misoprostol solution was administered as (1) 20 μg hourly (≤4 doses) that was increased in the absence of regular uterine contractions to 40 μg hourly (≤4 doses) and then to 60 μg hourly (≤16 doses) or (2) 25 μg every 2 hours until active labor began (≤12 doses)...
December 14, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27928864/vaginal-misoprostol-and-cervical-ripening-balloon-for-induction-of-labor-in-late-term-pregnancies
#12
Jorge Duro Gómez, María Fernanda Garrido Oyarzún, Ana Belén Rodríguez Marín, Antonio Jesús de la Torre González, José Eduardo Arjona Berral, Camil Castelo-Branco
AIM: The aim of this study was to compare vaginal misoprostol with the Cook cervical ripening balloon (CCRB) for induction of labor in late-term nulliparous women. METHODS: This open, quasi-experimental, prospective study included 109 nulliparous women with late-term pregnancies and Bishop scores < 7. Fifty-five women were allocated to receive vaginal misoprostol 25 mcg and 54 received the CCRB to induce labor. The primary outcome was the time until delivery...
December 8, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27921088/intra-uterine-extra-amniotic-versus-vaginal-misoprostol-for-termination-of-second-trimester-miscarriage-a-randomized-controlled-trial
#13
Abo Bakr Abbas Mitwaly, Ahmed Mohamed Abbas, Mohamed Sayed Abdellah
BACKGROUND: Termination of pregnancy in the second trimester using prostaglandins has been shown to be safe and effective. Misoprostol has multiple routes of administration; oral, vaginal, buccal, rectal and sublingual. OBJECTIVE: The study aims to compare the efficacy and safety of intrauterine extra-amniotic and vaginal misoprostol in a dose of 200 microgram every 4 hours for the termination of pregnancy in cases of second trimester miscarriage. MATERIALS AND METHODS: A prospective randomized open labeled clinical trial included 180 women with missed miscarriage in gestational age between 13 and 24 wks...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27918616/nitric-oxide-donors-for-cervical-ripening-and-induction-of-labour
#14
REVIEW
Arpita Ghosh, Katherine R Lattey, Anthony J Kelly
BACKGROUND: Sometimes it is necessary to bring on labour artificially because of safety concerns for the mother or baby. This review is one of a series of reviews of methods of labour induction using a standardised protocol. OBJECTIVES: To determine the effects of NO donors (isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), nitroglycerin and sodium nitroprusside) for third trimester cervical ripening or induction of labour, in comparison with placebo or no treatment or other treatments from a predefined hierarchy...
5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27903087/two-cervical-preparation-regimens-prior-to-surgical-abortion-at-10-14-weeks-of-gestation-a-randomized-clinical-trial
#15
Qingyun Guo, Zhida Qian, Lili Huang
BACKGROUND: The aim of the study was to determine whether same-day cervical preparation with an osmotic dilator and misoprostol was as effective and safe as overnight cervical preparation for surgical abortions at 10-14 weeks. METHODS: Seventy women seeking surgical abortion at 10-14 weeks were allocated to receive one osmotic dilator 16-17 h or 6-7 h prior to an abortion. All women received misoprostol 400 μg orally 2 h before the abortion. RESULTS: The abortion time of the same-day group was 7...
December 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27871315/management-of-uterine-rupture-a-case-report-and-review-of-the-literature
#16
Thomas Obinchemti Egbe, Gregory Edie Halle-Ekane, Charlotte Nguefack Tchente, Jacques Ernest Nyemb, Eugene Belley-Priso
BACKGROUND: Maternal morbidity and mortality has been a major World Health Organization concern over the years, especially in sub-Saharan Africa. This paper reports uterine rupture with severe hypovolemic shock managed at the Douala General Hospital, Cameroon. Early clinical diagnosis is paramount to maternal survival. CASE PRESENTATION: Mrs. MM aged 25 years, G3P2012, of the Bamileke tribe in Cameroon was admitted to our Department in hypovolemic shock BP = 70/40 mmHg, pulse 120 beats per minute, with altered consciousness (Glasgow Coma Scale = 13)...
November 21, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27871191/second-trimester-medical-abortion-with-mifepristone-followed-by-unlimited-dosing-of-buccal-misoprostol-in-armenia
#17
Karmen S Louie, Erica Chong, Tamar Tsereteli, Gayane Avagyan, Ruzanna Abrahamyan, Beverly Winikoff
OBJECTIVES: The aim of the study was to assess the efficacy and acceptability of a regimen using mifepristone and buccal misoprostol with unlimited dosing for second trimester abortion in Armenia. METHODS: Women seeking to terminate 13-22 week pregnancies were enrolled in the study. Participants swallowed 200 mg mifepristone in the clinic and were instructed to return to the hospital for induction 24-48 h later. During induction, women were given 400 μg buccal misoprostol every 3 h until the fetus and placenta were expelled...
November 21, 2016: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/27865944/misoprostol-exposure-during-the-first-trimester-of-pregnancy-is-the-malformation-risk-varying-depending-on-the-indication
#18
Marine Auffret, Nathalie Bernard-Phalippon, Joëlle Dekemp, Patrick Carlier, Marie Gervoise Boyer, Thierry Vial, Sophie Gautier
OBJECTIVE: To report the prospective follow-up of pregnancies exposed to misoprostol during the first trimester and analyse the teratogenic risk depending on the indication for use. STUDY DESIGN: Prospective observational study of 265 women exposed to misoprostol during the first 12 weeks of pregnancy and followed until the delivery. Women were included if they or their physician had contacted a French pharmacovigilance centre before 22 weeks of gestation (WG) to obtain information on the risk of misoprostol exposure, and if there had been misoprostol exposure before 13 WG...
December 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27843354/postpartum-hemorrhage-incidence-risk-factors-and-outcomes-in-a-low-resource-setting
#19
Solwayo Ngwenya
BACKGROUND: Primary postpartum hemorrhage (PPH) is defined as blood loss from the genital tract of 500 mL or more following a normal vaginal delivery (NVD) or 1,000 mL or more following a cesarean section within 24 hours of birth. PPH contributes significantly to maternal morbidity and mortality worldwide. Women can rapidly hemorrhage and die soon after giving birth. It can be a devastating outcome to many young families. Women giving birth in low-resource settings are at a higher risk of death than their counterparts in resource-rich environments...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27836586/intrauterine-contraception-after-medical-abortion-factors-affecting-success-of-early-insertion
#20
Elina Pohjoranta, Satu Suhonen, Maarit Mentula, Oskari Heikinheimo
OBJECTIVE: To assess the success and factors affecting early intrauterine device (IUD) provision after first trimester medical termination of pregnancy (MTOP). STUDY DESIGN: Subgroup analysis of a randomized contraceptive trial assessing the long-term effects of early provision of intrauterine contraception following abortion. Altogether, 606 women undergoing MTOP were included and followed for 3 months. The intervention group (n=307) was offered an IUD (either the levonorgestrel-releasing intrauterine system or copper-IUD) at a follow-up visit 1-4 weeks after MTOP...
November 9, 2016: Contraception
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