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Misoprostol

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https://www.readbyqxmd.com/read/29643818/intrinsic-hormone-like-molecules-and-external-root-resorption-during-orthodontic-tooth-movement-a-systematic-review-and-meta-analysis-in-preclinical-in-vivo-research
#1
Andreas Spoerri, Despina Koletsi, Theodore Eliades
Background: External root resorption constitutes an adverse effect of orthodontic treatment. The aim of the present meta-analysis was to identify the effect of induced intrinsic/ hormone-like molecules such as prostaglandins, interleukins and others on external root resorption after orthodontic tooth movement in experimental animals Methods: An electronic database search of the literature was performed (Medline via PubMed, EMBASE, LILACS, and Open Gray). Search terms included root resorption, tooth movement and animal type...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29624638/medical-management-of-miscarriage-predictive-factors-of-success
#2
Vanessa Lusink, Clare Wong, Bradley de Vries, Joanne Ludlow
Medical management of miscarriage is an acceptable option available to women, and has advantages of providing timely treatment, while avoiding exposure to surgery and anaesthesia. This retrospective cohort study aimed to determine factors predictive of successful medical management, utilising a single dose protocol of 800 µg vaginal misoprostol. In this cohort, the success rate was 67% (199/296), and smaller mean gestational sac diameter independent of gestational age predicted success (P = 0.046). Success is not significantly related to parity, miscarriage type, pelvic pain or vaginal bleeding at the outset of treatment...
April 6, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29614276/induction-of-labor-using-one-dose-versus-multiple-doses-of-misoprostol-a-randomized-controlled-trial
#3
Verónica Maria Pimentel, Moona Arabkhazaeli, Jee-Young Moon, Alexander Wang, Arisa Kapedani, Peter S Bernstein, Pamela J Tropper
BACKGROUND: Misoprostol is a common agent used to ripen the cervix and induce labor, yet there is no clear evidence of the optimal number of doses needed to achieve a higher rate of vaginal delivery. OBJECTIVE: Our primary objective was to compare the rate of vaginal delivery within 24 hours between a one-dose and a multiple-dose regimen of misoprostol for induction of labor STUDY DESIGN: A randomized controlled trial was conducted from March 2016 to March 2017 comparing a single dose to up to four doses of misoprostol...
March 31, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29610945/effect-of-maternal-obesity-on-labor-induction-in-postdate-pregnancy
#4
Ahmed M Maged, Ali M El-Semary, Heba M Marie, Doaa S Belal, Ayman Hany, Mohammad A Taymour, Eman F Omran, Sahar M Y Elbaradie, Mohamed A Kamal Mohamed
OBJECTIVE: To test the hypothesis that there is a higher rate of unsuccessful induction of labor (IOL) in post-term obese pregnant women compared to non-obese ones. METHODS: In this prospective cohort study, 144 obese (BMI > 30) and 144 non-obese (BMI < 29.9) post-term (> 41 weeks) pregnant women were recruited. IOL was done by misoprostol or amniotomy and oxytocin infusion according to the Bishop score. Comparison of percentage of failed IOL in both groups (primary outcome) was performed by the Chi-test...
April 2, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29603139/a-direct-to-patient-telemedicine-abortion-service-in-australia-retrospective-analysis-of-the-first-18-months
#5
Paul Hyland, Elizabeth G Raymond, Erica Chong
BACKGROUND: In 2015, the Tabbot Foundation launched a nationwide direct-to-patient telemedicine service to enable women to obtain medical abortion without visiting an abortion provider. AIMS: We aimed to describe results from the first 18 months of this service. MATERIALS AND METHODS: To have an abortion through the Foundation, a woman obtained screening tests locally and had a telephone consultation with a Foundation doctor. If she was eligible, mifepristone, misoprostol and other medications were sent to her by mail...
March 30, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29593817/identification-of-toxic-metals-in-human-embryonic-tissues
#6
Piotr Rzymski, Przemysław Niedzielski, Barbara Poniedziałek, Katarzyna Tomczyk, Paweł Rzymski
Introduction: The cause of a significant number of miscarriages remains unexplained. There is a need to identify the potential role of environmental, dietary and lifestyle factors in the risk of pregnancy loss. The present study was the first to investigate the content of miscarried embryonic material with respect to eight metals (aluminium, cadmium, chromium, copper, manganese, nickel, lead and zinc). Material and methods: Embryonic tissue samples ( n = 20) were obtained from women undergoing misoprostol-induced removal of the embryo between the 6th and 9th week of gestation...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29564312/effectiveness-and-safety-of-sublingual-misoprostol-in-medical-treatment-of-the-1st-trimester-miscarriage-experience-of-off-label-use-in-korea
#7
Jung Yeon Park, Hyo Jeong Ahn, Ba Raem Yoo, Kyu Ri Hwang, Taek Sang Lee, Hye Won Jeon, Sun Min Kim, Byoung Jae Kim
Objective: This study was conducted to determine the effectiveness and safety of medical treatment with sublingual misoprostol (MS) in the 1st trimester miscarriage under the approval by Health Insurance Review and Assessment Service (HIRA) for off-label usage by the single medical center in Korea. Methods: A retrospective cohort study was performed in one institution between April 2013 and June 2016. Ninety-one patients diagnosed with miscarriage before 14 weeks of gestation and wanted to try medical treatment were included...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29553433/management-of-pregnancy-loss-in-the-first-trimester-a-retrospective-audit
#8
Rami Musallam, Nabeel Salem, Ramez Al Halol, Hammam Al Deeb, Bettina Bottcher, Hanaa AlHamaida
BACKGROUND: Early pregnancy loss occurs in 10% of all clinically recognised pregnancies. 80% of pregnancy losses occur in the first trimester. Offering choice and participation in the management decisions is essential to patient-centred care. The aim of this study was to assess the management of first trimester pregnancy loss at the Emirati Hospital in Rafah, Gaza Strip. METHODS: In this retrospective audit, we compared the management of first trimester pregnancy loss at Emirati Hospital using the American College of Obstetricians and Gynecologists guidelines (ACOG, No...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29534996/low-sensitivity-urine-pregnancy-testing-to-assess-medical-abortion-outcome-a-systematic-review
#9
REVIEW
Elizabeth G Raymond, Tara Shochet, Hillary Bracken
OBJECTIVES: To summarize data on the accuracy and acceptability of a strategy for identifying ongoing pregnancy after medical abortion treatment using a low-sensitivity pregnancy test (LSPT). STUDY DESIGN: We searched PubMed to identify studies that evaluated the use of a single post-treatment LSPT for detection of ongoing pregnancy after treatment with mifepristone and misoprostol. We extracted, assessed, and summarized data from each study. RESULTS: We found 10 studies that evaluated 6 LSPTs with human chorionic gonadotropin detection thresholds of 1000, 1500, or 2000 mIU/ml...
March 10, 2018: Contraception
https://www.readbyqxmd.com/read/29528933/simultaneous-compared-with-interval-medical-abortion-regimens-where-home-use-is-restricted
#10
Patricia A Lohr, Jennifer E Starling, James G Scott, Abigail R A Aiken
OBJECTIVE: To evaluate outcomes with simultaneous administration of mifepristone and misoprostol for medical abortion at 63 days of gestation or less in the year after its implementation in a British clinic system. METHODS: We conducted a retrospective cohort study using deidentified data from the electronic booking and complications databases and medical records of women who underwent medical abortion at British Pregnancy Advisory Service. Our primary outcome was treatment success with simultaneous dosing compared with a regimen with a 24- to 48-hour interval between medications...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29528924/harm-reduction-for-abortion-in-the-united-states
#11
Julia Tasset, Lisa H Harris
Access to abortion in the United States has eroded significantly. Accordingly, there is a growing movement to empower women to self-induce abortion. To date, physicians' roles and responsibilities in this changing environment have not been defined. Here, we consider a harm reduction approach to first-trimester abortion as a way for physicians to honor clinical and moral obligations to care for women, negotiate ever-increasing abortion restrictions, and support women who consider abortion self-induction. Harm reduction approaches to abortion have been successfully implemented in a range of countries around the world and typically take the form of teaching women how to use misoprostol...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29490288/use-of-medications-to-decrease-bleeding-during-surgical-abortion-a-survey-of-abortion-providers-practices-in-the-united-states
#12
Katherine Whitehouse, Tiana Fontanilla, Leslie Kim, Mary Tschann, Reni Soon, Jennifer Salcedo, Bliss Kaneshiro
OBJECTIVE: Our objective was to document current practices of abortion providers on the use of medications to decrease bleeding during surgical abortion. STUDY DESIGN: We emailed surveys to 336 abortion providers through a professional listserv to elicit information on their use of medications to prevent and treat bleeding during first- and second-trimester surgical abortion. RESULTS: One hundred sixty-eight (50%) providers responded to our survey...
February 25, 2018: Contraception
https://www.readbyqxmd.com/read/29462500/antifibrinolytic-drugs-for-treating-primary-postpartum-haemorrhage
#13
REVIEW
Haleema Shakur, Danielle Beaumont, Sue Pavord, Angele Gayet-Ageron, Katharine Ker, Hatem A Mousa
BACKGROUND: Postpartum haemorrhage (PPH) - heaving bleeding within the first 24 hours after giving birth - is one of the main causes of death of women after childbirth. Antifibrinolytics, primarily tranexamic acid (TXA), have been shown to reduce bleeding in surgery and safely reduces mortality in trauma patients with bleeding without increasing the risk of adverse events.An earlier Cochrane review on treatments for primary PPH covered all the various available treatments - that review has now been split by types of treatment...
February 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29451883/management-of-post-abortion-complications-in-botswana-the-need-for-a-standardized-approach
#14
Tadele Melese, Dereje Habte, Billy M Tsima, Keitshokile Dintle Mogobe, Mercy N Nassali
BACKGROUND: Post abortion complications are the third leading cause of maternal death after hemorrhage and hypertension in Botswana where abortion is not legalized. This study aimed at assessing the management of post abortion complications in Botswana. METHODS: A retrospective study was conducted at four hospitals in Botswana in 2014. Socio-demographic, patient management and outcomes data were extracted from patients' medical records. Descriptive statistics and chi-square test were used to analyze and present the data...
2018: PloS One
https://www.readbyqxmd.com/read/29440163/severity-and-management-of-postabortion-complications-among-women-in-zimbabwe-2016-a-cross-sectional-study
#15
Mugove Gerald Madziyire, Chelsea B Polis, Taylor Riley, Elizabeth A Sully, Onikepe Owolabi, Tsungai Chipato
OBJECTIVES: Abortion complications cause significant morbidity and mortality. We aimed to assess the severity and factors associated with abortion complications (induced or spontaneous), and the management of postabortion care (PAC) in Zimbabwe. DESIGN: Prospective, facility-based 28 day survey among women seeking PAC and their providers. SETTING: 127 facilities in Zimbabwe with the capacity to provide PAC, including all central and provincial hospitals, and a sample of primary health centres (30%), district/general/mission hospitals (52%), private (77%) and non-governmental organisation (NGO) (68%) facilities...
February 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438271/efficacy-of-misoprostol-before-diagnostic-hysteroscopy-in-postmenopausal-women-a-randomized-clinical-trial
#16
Fabiana Y Nakano, Daniela A Yela, Joao P L Pinto, Talita Riegas, Cristina L Benetti-Pinto, Adriana Orcesi Pedro, Lucia Helena Costa Paiva
OBJECTIVE: To evaluate pain and determine the efficacy of misoprostol, compared with placebo, for postmenopausal women before diagnostic hysteroscopy. METHODS: This randomized, double-blind, placebo-controlled clinical trial included 158 postmenopausal women who received either 200 μg of misoprostol or placebo through the vaginal route before diagnostic hysteroscopy (79 women/group). The primary outcome was pain assessment (presence and intensity) during the four steps of hysteroscopy: cervical grasping with a Pozzi tenaculum forceps immediately before hysteroscopy, during hysteroscopy, during performance of the endometrial biopsy, and postprocedure...
February 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29438118/nsaids-and-the-small-bowel
#17
Foong Way David Tai, Mark E McAlindon
PURPOSE OF REVIEW: The review describes the effects of NSAID gastrointestinal toxicity on the small bowel, wherein injury is as prevalent as in the gastroduodenum. This is well documented by capsule endoscopy, which also provides an endoscopic endpoint for novel treatment strategies. RECENT FINDINGS: Appreciation of the prevalence of NSAID enteropathy has grown with capsule endoscopy and the use of composite end points that include obscure haemoglobin decreases in clinical studies...
May 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29421836/drugs-in-pregnancy-and-lactation-medications-used-in-swiss-obstetrics
#18
Larissa Schenkel, Ana Paula Simões-Wüst, Irene Hösli, Ursula von Mandach
BACKGROUND: In order to improve the safety for drugs in pregnancy and lactation, data on the clinical practice must be collected and validated. METHODS: Data on the medications routinely used were requested from the university hospitals for obstetrics and the non-university perinatal centres in Switzerland and recommendations and guidelines of scientific societies for the various fields of application were sought. RESULTS: Part I: For during pregnancy and the peripartal period respectively, 69 and 21 different active constituents of medications were identified from at least 4 centres...
February 8, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29409965/optimal-dose-of-vaginal-misoprostol-for-cervical-ripening-before-hysteroscopy-a-randomized-double-blind-study
#19
Ji Young Hwang, Seung Hun Song
STUDY OBJECTIVE: To evaluate the optimal dose of vaginal misoprostol (200 and 400 mcg) for cervical priming before operative hysteroscopy. DESIGN: Prospective, randomized, controlled, double-blind trial (Canadian Task Force classification I). SETTING: University hospital. PATIENTS: Sixty eight patients undergoing operative hysteroscopy. INTERVENTIONS: Patients were randomized to receive a low (200 mcg) or high (400 mcg) dose of misoprostol administered vaginally 8 hours before operative hysteroscopy...
January 30, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29409456/task-shifting-in-active-management-of-the-third-stage-of-labor-a-systematic-review
#20
Tessa M Raams, Joyce L Browne, Verena J M M Festen-Schrier, Kerstin Klipstein-Grobusch, Marcus J Rijken
BACKGROUND: Active management of the third stage of labor (AMTSL) describes interventions with the common goal to prevent postpartum hemorrhage (PPH). In low- and middle-income countries, implementation of AMTSL is hampered by shortage of skilled birth attendants and a high percentage of home deliveries. Task shifting of specific AMTSL components to unskilled birth attendants or self-administration could be a strategy to increase access to potentially life-saving interventions. This study was designed to evaluate the effect, acceptance and safety of task shifting of specific aspects of AMTSL to unskilled birth attendants...
February 6, 2018: BMC Pregnancy and Childbirth
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