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https://www.readbyqxmd.com/read/29451883/management-of-post-abortion-complications-in-botswana-the-need-for-a-standardized-approach
#1
Tadele Melese, Dereje Habte, Billy M Tsima, Keitshokile Dintle Mogobe, Mercy N Nassali
BACKGROUND: Post abortion complications are the third leading cause of maternal death after hemorrhage and hypertension in Botswana where abortion is not legalized. This study aimed at assessing the management of post abortion complications in Botswana. METHODS: A retrospective study was conducted at four hospitals in Botswana in 2014. Socio-demographic, patient management and outcomes data were extracted from patients' medical records. Descriptive statistics and chi-square test were used to analyze and present the data...
2018: PloS One
https://www.readbyqxmd.com/read/29440163/severity-and-management-of-postabortion-complications-among-women-in-zimbabwe-2016-a-cross-sectional-study
#2
Mugove Gerald Madziyire, Chelsea B Polis, Taylor Riley, Elizabeth A Sully, Onikepe Owolabi, Tsungai Chipato
OBJECTIVES: Abortion complications cause significant morbidity and mortality. We aimed to assess the severity and factors associated with abortion complications (induced or spontaneous), and the management of postabortion care (PAC) in Zimbabwe. DESIGN: Prospective, facility-based 28 day survey among women seeking PAC and their providers. SETTING: 127 facilities in Zimbabwe with the capacity to provide PAC, including all central and provincial hospitals, and a sample of primary health centres (30%), district/general/mission hospitals (52%), private (77%) and non-governmental organisation (NGO) (68%) facilities...
February 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438271/efficacy-of-misoprostol-before-diagnostic-hysteroscopy-in-postmenopausal-women-a-randomized-clinical-trial
#3
Fabiana Y Nakano, Daniela A Yela, Joao P L Pinto, Talita Riegas, Cristina L Benetti-Pinto, Adriana Orcesi Pedro, Lucia Helena Costa Paiva
OBJECTIVE: To evaluate pain and determine the efficacy of misoprostol, compared with placebo, for postmenopausal women before diagnostic hysteroscopy. METHODS: This randomized, double-blind, placebo-controlled clinical trial included 158 postmenopausal women who received either 200 μg of misoprostol or placebo through the vaginal route before diagnostic hysteroscopy (79 women/group). The primary outcome was pain assessment (presence and intensity) during the four steps of hysteroscopy: cervical grasping with a Pozzi tenaculum forceps immediately before hysteroscopy, during hysteroscopy, during performance of the endometrial biopsy, and postprocedure...
February 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29438118/nsaids-and-the-small-bowel
#4
Foong Way David Tai, Mark E McAlindon
PURPOSE OF REVIEW: The review describes the effects of NSAID gastrointestinal toxicity on the small bowel, wherein injury is as prevalent as in the gastroduodenum. This is well documented by capsule endoscopy, which also provides an endoscopic endpoint for novel treatment strategies. RECENT FINDINGS: Appreciation of the prevalence of NSAID enteropathy has grown with capsule endoscopy and the use of composite end points that include obscure haemoglobin decreases in clinical studies...
February 12, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29421836/drugs-in-pregnancy-and-lactation-medications-used-in-swiss-obstetrics
#5
Larissa Schenkel, Ana Paula Simões-Wüst, Irene Hösli, Ursula von Mandach
BACKGROUND: In order to improve the safety for drugs in pregnancy and lactation, data on the clinical practice must be collected and validated. METHODS: Data on the medications routinely used were requested from the university hospitals for obstetrics and the non-university perinatal centres in Switzerland and recommendations and guidelines of scientific societies for the various fields of application were sought. RESULTS: Part I: For during pregnancy and the peripartal period respectively, 69 and 21 different active constituents of medications were identified from at least 4 centres...
February 8, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29409965/optimal-dose-of-vaginal-misoprostol-for-cervical-ripening-before-hysteroscopy-a-randomized-double-blind-study
#6
Ji Young Hwang, Seung Hun Song
STUDY OBJECTIVE: To evaluate the optimal dose of vaginal misoprostol (200 and 400 mcg) for cervical priming before operative hysteroscopy. DESIGN: Prospective, randomized, controlled, double-blind trial (Canadian Task Force classification I). SETTING: University hospital. PATIENTS: Sixty eight patients undergoing operative hysteroscopy. INTERVENTIONS: Patients were randomized to receive a low (200 mcg) or high (400 mcg) dose of misoprostol administered vaginally 8 hours before operative hysteroscopy...
January 30, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29409456/task-shifting-in-active-management-of-the-third-stage-of-labor-a-systematic-review
#7
Tessa M Raams, Joyce L Browne, Verena J M M Festen-Schrier, Kerstin Klipstein-Grobusch, Marcus J Rijken
BACKGROUND: Active management of the third stage of labor (AMTSL) describes interventions with the common goal to prevent postpartum hemorrhage (PPH). In low- and middle-income countries, implementation of AMTSL is hampered by shortage of skilled birth attendants and a high percentage of home deliveries. Task shifting of specific AMTSL components to unskilled birth attendants or self-administration could be a strategy to increase access to potentially life-saving interventions. This study was designed to evaluate the effect, acceptance and safety of task shifting of specific aspects of AMTSL to unskilled birth attendants...
February 6, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29408754/elective-abortion-clinical-practice-guidelines-from-the-french-college-of-gynecologists-and-obstetricians-cngof
#8
REVIEW
Christophe Vayssière, Adrien Gaudineau, Luisa Attali, Karima Bettahar, Sophie Eyraud, Philippe Faucher, Patrick Fournet, Danielle Hassoun, Marie Hatchuel, Christian Jamin, Brigitte Letombe, Teddy Linet, Marie Msika Razon, Alexandra Ohanessian, Hélène Segain, Solène Vigoureux, Norbert Winer, Sophie Wylomanski, Aubert Agostini
The number of elective abortions has been stable for several decades. Many factors explain women's choice of abortion in cases of unplanned pregnancies. Early initiation of contraceptive use and a choice of contraceptive choices appropriate to the woman's life are associated with lower rates of unplanned pregnancies. Reversible long-acting contraceptives should be favored as first-line methods for adolescents because of their effectiveness (grade C). Ultrasound scan before an elective abortion must be encouraged but should not be obligatory (professional consensus)...
January 26, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29393690/benefits-of-vaginal-misoprostol-prior-to-iud-insertion-in-women-with-previous-caesarean-delivery-a-randomised-controlled-trial
#9
Ahmed M Maged, Gamal Youssef, Ashraf Eldaly, Eman Omran, Mohamed El Naggar, Ahmed Abdel Hak, Amal Kotb, Asmaa I Ogila
OBJECTIVE: The aim of the study was to evaluate the value of vaginal misoprostol 6 h prior to intrauterine device (IUD) insertion in women with previous Caesarean delivery. METHODS: A double-blind randomised controlled trial was conducted in 120 women who were eligible for IUD insertion. Participants were randomly divided to receive either 600 μg vaginal misoprostol or placebo 6 h before IUD insertion. The primary outcome measure was the pain score during the procedure...
February 2, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29391674/comparison-of-mifepristone-followed-by-misoprostol-with-misoprostol-alone-for-treatment-of-early-pregnancy-failure-a-randomized-double-blind-placebo-controlled-trial
#10
Priya Sinha, Amita Suneja, Kiran Guleria, Richa Aggarwal, Neelam B Vaid
Objective: To compare the efficacy and safety of mifepristone followed by misoprostol with misoprostol alone in the management of early pregnancy failure (EPF). Study Design: A randomized double-blind placebo-controlled clinical trial. Methods: Ninety-two women with EPF ≤12 weeks were recruited and randomly allocated to receive either mifepristone 200 mg (n = 46) or placebo (n = 46). Forty-eight hours later, patients in both the groups were given 800 µg misoprostol per-vaginum...
February 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29390996/realising-the-right-to-sexual-and-reproductive-health-access-to-essential-medicines-for-medical-abortion-as-a-core-obligation
#11
Katrina Perehudoff, Lucía Berro Pizzarossa, Jelle Stekelenburg
BACKGROUND: WHO has a pivotal role to play as the leading international agency promoting good practices in health and human rights. In 2005, mifepristone and misoprostol were added to WHO's Model List of Essential Medicines for combined use to terminate unwanted pregnancies. However, these drugs were considered 'complementary' and qualified for use when in line with national legislation and where 'culturally acceptable'. DISCUSSION: This article argues that these qualifications, while perhaps appropriate at the time, must now be removed...
February 1, 2018: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/29382306/quality-medicines-in-maternal-health-results-of-oxytocin-misoprostol-magnesium-sulfate-and-calcium-gluconate-quality-audits
#12
Chimezie Anyakora, Yetunde Oni, Uchenna Ezedinachi, Adebola Adekoya, Ibrahim Ali, Charles Nwachukwu, Charles Esimone, Victor Abiola, Jude Nwokike
BACKGROUND: The high level of maternal mortality and morbidity as a result of complications due to childbirth is unacceptable. The impact of quality medicines in the management of these complications cannot be overemphasized. Most of those medicines are sensitive to environmental conditions and must be handled properly. In this study, the quality of oxytocin injection, misoprostol tablets, magnesium sulfate, and calcium gluconate injections was assessed across the six geopolitical zones of Nigeria...
January 30, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29377641/malformations-attributed-to-the-process-of-vascular-disruption
#13
Lewis B Holmes, Marie-Noel Westgate, Hanah Nasri, M Hassan Toufaily
BACKGROUND: Several malformations have been attributed to the process of vascular disruption. The central hypothesis for this etiology is that blood flow to a structure has been altered after that structure had formed normally. The decreased blood flow leads to hypoxia, endothelial cell damage, hemorrhage, tissue loss, and repair. After recovery, some structures are normal and others show either tissue loss or structural abnormalities, such as syndactyly and constriction rings. METHODS: The phenotypic features of the 7,020 infants with one or more malformations, who were born to women who had always planned to deliver at Brigham and Women's Hospital (BWH) between, 1972 and 2012, that is, maternal nontransfers, were reviewed...
January 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29376620/oral-misoprostol-versus-intravaginal-dinoprostone-for-labor-induction-a-comparison-study
#14
Caterina Neri, Alessandra Familiari, Francesco Preziosi, Chiara Vassallo, Angela Botta, Antonio Lanzone, Brigida Carducci, Alessandro Caruso
BACKGROUND: Labor induction (IOL) is one of the most common procedures performed in obstetrics, accounting for about the 20% of deliveries in the developed countries and it still represents a challenge to obstetricians. PURPOSE: The aim of this study is the comparison between two techniques for induction of Labor (IOL): oral Misoprostol and Propess. MATERIALS AND METHODS: Restrospective study in a single tertiary referral center. Clinical maternal, fetal and neonatal informations were recorded...
January 26, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29375147/letrozole-vs-placebo-pretreatment-in-the-medical-management-of-first-trimester-missed-miscarriage-a-randomized-controlled-trial
#15
Haitham A Torky, Heba Marie, ElSayed ElDesouky, Samy Gebreel, Osama Raslan, Asem A Moussa, Ali M Ahmad, Eman Zain, Mohamed N Mohsen
Introduction: Misoprostol is used for the medical management of miscarriage as it is more effective in the early stages of pregnancy. Letrozole has an anti-estrogen effect and is used for the pretreatment of miscarriage with misoprostol. Aim: The aim of this study was compare the efficacy and safety of letrozole with placebo pretreatment in the medical management of first trimester missed miscarriage. Design: This was a prospective randomized case-control study...
January 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29360138/interventions-to-reduce-acute-and-late-adverse-gastrointestinal-effects-of-pelvic-radiotherapy-for-primary-pelvic-cancers
#16
REVIEW
Theresa A Lawrie, John T Green, Mark Beresford, Linda Wedlake, Sorrel Burden, Susan E Davidson, Simon Lal, Caroline C Henson, H Jervoise N Andreyev
BACKGROUND: An increasing number of people survive cancer but a significant proportion have gastrointestinal side effects as a result of radiotherapy (RT), which impairs their quality of life (QoL). OBJECTIVES: To determine which prophylactic interventions reduce the incidence, severity or both of adverse gastrointestinal effects among adults receiving radiotherapy to treat primary pelvic cancers. SEARCH METHODS: We conducted searches of CENTRAL, MEDLINE, and Embase in September 2016 and updated them on 2 November 2017...
January 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29351313/effectiveness-and-safety-of-early-medication-abortion-provided-in-pharmacies-by-auxiliary-nurse-midwives-a-non-inferiority-study-in-nepal
#17
Corinne H Rocca, Mahesh Puri, Prabhakar Shrestha, Maya Blum, Dev Maharjan, Daniel Grossman, Kiran Regmi, Philip D Darney, Cynthia C Harper
BACKGROUND: Expanding access to medication abortion through pharmacies is a promising avenue to reach women with safe and convenient care, yet no pharmacy provision interventions have been evaluated. This observational non-inferiority study investigated the effectiveness and safety of mifepristone-misoprostol medication abortion provided at pharmacies, compared to government-certified public health facilities, by trained auxiliary nurse-midwives in Nepal. METHODS: Auxiliary nurse-midwives were trained to provide medication abortion through twelve pharmacies and public facilities as part of a demonstration project in two districts...
2018: PloS One
https://www.readbyqxmd.com/read/29327156/effectiveness-of-celecoxib-for-pain-relief-and-antipyresis-in-second-trimester-medical-abortions-with-misoprostol-a-randomized-controlled-trial
#18
Hatern Tintara, Peangpailin Voradithi, Thanapan Choobun
PURPOSE: To evaluate the effectiveness of celecoxib for pain relief and antipyresis during second trimester abortion using sublingual misoprostol. METHODS: Fifty-six pregnant women of gestational age 14-24 weeks were randomly assigned in a double-blind randomized controlled trial to receive 400 mg of celecoxib or placebo just before sublingual administration of misoprostol 400 µg every 6 h. Pain and body temperature (BT) were assessed every 1 h until the abortion or 24 h after the first dose of misoprostol...
January 11, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29320513/a-harm-reduction-model-of-abortion-counseling-about-misoprostol-use-in-peru-with-telephone-and-in-person-follow-up-a-cohort-study
#19
Daniel Grossman, Sarah E Baum, Denitza Andjelic, Carrie Tatum, Guadalupe Torres, Liza Fuentes, Jennifer Friedman
BACKGROUND: In Peru, abortion is legal only to preserve the life and health of the woman. A non-profit clinic system in Peru implemented a harm-reduction model for women with unwanted pregnancy that included pre-abortion care with instructions about misoprostol use and post-abortion care; they started offering telephone follow-up for clients in 2011. This study aimed to evaluate the effectiveness and safety of the harm-reduction model, and to compare outcomes by type of follow-up obtained...
2018: PloS One
https://www.readbyqxmd.com/read/29304769/a-comparison-of-misoprostol-vaginal-insert-and-misoprostol-vaginal-tablets-for-induction-of-labor-in-nulliparous-women-a-retrospective-cohort-study
#20
Kjersti Engen Marsdal, Ingvil Krarup Sørbye, Lise C Gaudernack, Mirjam Lukasse
BACKGROUND: Since Misoprostol Vaginal Insert (MVI - Misodel ®) was approved for labor induction in Europe in 2013, to date, no study has been published comparing MVI to Misoprostol vaginal tablets (MVT). The aim of this study, performed as part of a quality improvement project, was to compare the efficacy and safety of 200 μg MVI versus 25 μg MVT for labor induction in nulliparous women. METHODS: This retrospective cohort study included 171 nulliparous singleton term deliveries induced with MVI (n = 85) versus MVT (n = 86) at Oslo University Hospital Rikshospitalet, Norway, from November 2014 to December 2015...
January 5, 2018: BMC Pregnancy and Childbirth
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