Xin-Fang Lv, Ruo-Qing Wen, Kai Liu, Xin-Ke Zhao, Chen-Liang Pan, Xiang Gao, Xue Wu, Xiao-Dong Zhi, Chun-Zhen Ren, Qi-Lin Chen, Wei-Jie Lu, Ting-Yan Bai, Ying-Dong Li
Cardiotoxicity is a serious complication of cancer therapy. It is the second leading cause of morbidity and mortality in cancer survivors and is associated with a variety of factors, including oxidative stress, inflammation, apoptosis, autophagy, endoplasmic reticulum stress, and abnormal myocardial energy metabolism. A number of studies have shown that traditional Chinese medicine (TCM) can mitigate chemoradiotherapy-associated cardiotoxicity via these pathways. Therefore, this study reviews the effects and molecular mechanisms of TCM on chemoradiotherapy-related cardiotoxicity...
2022: Frontiers in Cardiovascular Medicine