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https://www.readbyqxmd.com/read/28107758/retroperitoneal-unicentric-castleman-s-disease-a-case-report
#1
Nihed Abdessayed, Ahlem Bdioui, Houssem Ammar, Rahul Gupta, Nozha Mhamdi, Marwa Guerfela, Moncef Mokni
INTRODUCTION: Castleman's disease (CD) is an angio-follicular lymph node hyperplasia presenting as a localized or a systemic disease masquerading malignancy. The most common sites of CD are mediastinum, neck, axilla and pelvis. Unicentric CD in the peripancreatic region is very rare. PRESENTATION OF CASE: We report a case of the 34-year-old lady presenting with epigastric pain for 3 months. Abdominal imaging revealed a retroperitoneal mass arising from the pancreas suspected to be neuroendocrine tumor...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28107624/tocilizumab-alendronate-conjugate-for-treatment-of-rheumatoid-arthritis
#2
Hwiwon Lee, Suk Ho Bhang, Jeong Ho Lee, Hyemin Kim, Sei Kwang Hahn
An autoimmune disease of rheumatoid arthritis (RA) causes severe inflammation on the synovial membrane, which results in the destruction of articular cartilage and bone. Here, Tocilizumab (TCZ) - Alendronate (ALD) conjugate is synthesized for the early intervention of RA. A humanized monoclonal antibody of TCZ shows an immunosuppressive effect, targeting interleukin-6 (IL-6) receptor in the RA pathogenesis. ALD is an anti-inflammatory bisphosphonate drug which can bind to the exposed bone surface. ALD is conjugated selectively to N-glycan on Fc region of TCZ using a chemical linker of 3-(2-pyridyldithio) propionyl hydrazide (PDPH) - poly(ethylene glycol) - N-hydroxysuccinimide (PDPH-PEG-NHS)...
January 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28107549/detection-of-alect2-amyloidosis-by-positron-emission-tomography-computed-tomography-imaging-with-florbetapir
#3
Nelson Leung, Marina Ramirez-Alvarado, Samih H Nasr, Bradley J Kemp, Geoffrey B Johnson
No abstract text is available yet for this article.
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28107543/quantification-of-pulmonary-fibrosis-in-a-bleomycin-mouse-model-using-automated-histological-image-analysis
#4
Jean-Claude Gilhodes, Yvon Julé, Sebastian Kreuz, Birgit Stierstorfer, Detlef Stiller, Lutz Wollin
Current literature on pulmonary fibrosis induced in animal models highlights the need of an accurate, reliable and reproducible histological quantitative analysis. One of the major limits of histological scoring concerns the fact that it is observer-dependent and consequently subject to variability, which may preclude comparative studies between different laboratories. To achieve a reliable and observer-independent quantification of lung fibrosis we developed an automated software histological image analysis performed from digital image of entire lung sections...
2017: PloS One
https://www.readbyqxmd.com/read/28107468/micro-x-ray-computed-tomography-mass-loss-assessment-of-different-uhmwpe-a-hip-joint-simulator-study-on-standard-vs-cross-linked-polyethylene
#5
Saverio Affatato, Filippo Zanini, Simone Carmignato
More than 60.000 hip arthroplasty are performed every year in Italy. Although Ultra-High-Molecular-Weight-Polyethylene remains the most used material as acetabular cup, wear of this material induces over time in vivo a foreign-body response and consequently osteolysis, pain, and the need of implant revision. Furthermore, oxidative wear of the polyethylene provoke several and severe failures. To solve these problems, highly cross-linked polyethylene and Vitamin-E-stabilized polyethylene were introduced in the last years...
2017: PloS One
https://www.readbyqxmd.com/read/28107436/a-micro-ct-study-in-patients-with-breast-microcalcifications-using-a-mathematical-algorithm-to-assess-3d-structure
#6
David Kenkel, Zsuzsanna Varga, Heike Heuer, Konstantin J Dedes, Nicole Berger, Lukas Filli, Andreas Boss
PURPOSE: The aim of this study was to evaluate the relevance of the three-dimensional (3D) structure of breast microcalcifications (MC) as a predictor of malignancy using highly resolved micro-computed tomography (micro-CT) datasets of biopsy samples. MATERIAL AND METHODS: The study included 28 women with suspicious MC in their mammogram undergoing vacuum-assisted biopsy. Directly after the intervention, the specimens were scanned in a micro-CT with an isometric spatial resolution of 9 μm...
2017: PloS One
https://www.readbyqxmd.com/read/28107411/xenon-enhanced-dual-energy-ct-imaging-in-combined-pulmonary-fibrosis-and-emphysema
#7
Keishi Sugino, Masahiro Kobayashi, Yasuhiko Nakamura, Kyoko Gocho, Fumiaki Ishida, Kazutoshi Isobe, Nobuyuki Shiraga, Sakae Homma
BACKGROUND: Little has been reported on the feasibility of xenon-enhanced dual-energy computed tomography (Xe-DECT) in the visual and quantitative analysis of combined pulmonary fibrosis and emphysema (CPFE). OBJECTIVES: We compared CPFE with idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), as well as correlation with parameters of pulmonary function tests (PFTs). METHODS: Studied in 3 groups were 25 patients with CPFE, 25 with IPF without emphysema (IPF alone), 30 with COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28107246/reliability-and-usefulness-of-intraoperative-3-dimensional-imaging-by-mobile-c-arm-with-flat-panel-detector
#8
Takahito Fujimori, Motoki Iwasaki, Yukitaka Nagamoto, Masafumi Kashii, Masaki Takao, Tsuyoshi Sugiura, Hideki Yoshikawa
STUDY DESIGN: Reliability and agreement study. OBJECTIVE: To assess the reliability of intraoperative 3-dimensional imaging with a mobile C-arm (3D C-arm) equipped with a flat-panel detector. SUMMARY OF BACKGROUND DATA: Pedicle screws are widely used in spinal surgery. Postoperative computed tomography (CT) is the most reliable method to detect screw misplacement. Recent advances in imaging devices have enabled surgeons to acquire 3D images of the spine during surgery...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107234/comparison-between-acrylic-cage-and-polyetheretherketone-peek-cage-in-single-level-anterior-cervical-discectomy-and-fusion-a-randomized-clinical-trial
#9
Majid R Farrokhi, Zahra Nikoo, Mehrnaz Gholami, Khadijeh Hosseini
STUDY DESIGN: Prospective, single-blind randomized-controlled clinical study. OBJECTIVE: To compare polyetheretherketone (PEEK) cage with a novel Acrylic cage to find out which fusion cage yielded better clinical outcomes following single-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is considered a standard neurosurgical treatment for degenerative diseases of cervical intervertebral disks. There are many options, including bone grafts, bone cement, and spacers made of titanium, carbon fiber, and synthetic materials, used to restore physiological disk height and enhance spinal fusion, but the ideal device, which would provide immediate structural support and subsequent osteointegration and stability, has not been identified yet...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107213/computed-tomography-in-the-management-of-adrenal-tumors-does-size-still-matter
#10
Saïd C Azoury, Neeraja Nagarajan, Allen Young, Aarti Mathur, Jason D Prescott, Elliot K Fishman, Martha A Zeiger
OBJECTIVE: We sought to evaluate computed tomography (CT) imaging as a predictor of adrenal tumor pathology. METHODS: A retrospective review was conducted of patients who underwent unilateral adrenalectomy for an adrenal mass between January 2005 and July 2015. Tumors were classified as benign, indeterminate, or malignant based on preoperative CT findings. RESULTS: Of 697 patients who underwent unilateral adrenalectomy, 216 met the inclusion criteria...
January 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28107092/a-solid-pseudopapillary-neoplasm-of-the-pancreas-associated-with-igg4-related-pancreatitis
#11
Yuichiro Hatano, Keisuke Kawashima, Takuji Iwashita, Masaki Kimura, Masahito Shimizu, Akira Hara
A solid and cystic pancreatic lesion was incidentally found in a 62-year-old woman on abdominal computed tomography. The lesion was diagnosed as a solid pseudopapillary neoplasm by using endoscopic ultrasound-guided fine needle aspiration, and the tumor was resected. Histologically, the tumor cells had relatively small, round nuclei and papillary-like architecture in a hemorrhagic background. On immunohistochemical examination, the tumor cells were diffusely positive for nuclear β-catenin and cytoplasmic CD10...
November 1, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28106942/assessment-of-intracranial-meningioma-associated-calcifications-using-susceptibility-weighted-mri
#12
Lisa C Adams, Sarah M Böker, Yvonne Y Bender, Eva M Fallenberg, Moritz Wagner, Ralph Buchert, Bernd Hamm, Marcus R Makowski
PURPOSE: To determine the diagnostic accuracy of susceptibility-weighted MRI (SW-MRI) for the detection of intracranial meningioma-associated calcifications compared with standard MR sequences, using computed tomography (CT) as a reference standard. MATERIALS AND METHODS: 354 patients, who had received both a CT and a 1.5 Tesla clinical brain MRI with SW-MRI sequences between January 2014 and July 2016, were retrospectively evaluated and 316 patients were included...
January 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28106911/positron-emission-tomography-computed-tomography-imaging-of-adrenocorticotropic-hormone-producing-small-cell-neuroendocrine-carcinoma-of-the-cervix
#13
Vien X Nguyen, Ba D Nguyen, Dora M Lam-Himlin
Ectopic ACTH-dependent Cushing syndrome-inducing small-cell neuroendocrine carcinoma of the cervix, undiagnosed by computed tomography and whole-body octreotide scintigraphy, was identified using F-18 FDG PET/CT imaging. This article is protected by copyright. All rights reserved.
January 20, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28106704/rapid-spontaneously-resolving-acute-subdural-hematoma
#14
Qi Gan, Hexiang Zhao, Hanmei Zhang, Chao You
INTRODUCTION: This study reports a rare patient of a rapid spontaneously resolving acute subdural hematoma. In addition, an analysis of potential clues for the phenomenon is presented with a review of the literature. PATIENT PRESENTATION: A 1-year-and-2-month-old boy fell from a height of approximately 2 m. The patient was in a superficial coma with a Glasgow Coma Scale of 8 when he was transferred to the authors' hospital. Computed tomography revealed the presence of an acute subdural hematoma with a midline shift beyond 1 cm...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106698/do-the-angle-and-length-of-the-eustachian-tube-affect-the-success-rate-of-pediatric-cartilage-type-1-tympanoplasty
#15
Yakup Yegin, Mustafa Çelik, Ahmet Altintaş, Ceylan Çolak, Fatma Tülin Kayhan
OBJECTIVES: To investigate the relationships between the angle and length of the Eustachian tube (ET) (the ETa and the ETl) and the success rates of pediatric type 1 tympanoplasty. STUDY DESIGN: A retrospective clinical chart review. METHODS: In total, 51 children (31 females and 20 males; average age, 11.92 ± 3.46 years; age range: 7-18 years) who underwent cartilage type 1 tympanoplasty were included. Demographics and anatomical outcomes were recorded...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106615/metal-artifact-reduction-in-x-ray-computed-tomography-using-computer-aided-design-data-of-implants-as-prior-information
#16
Veikko Ruth, Daniel Kolditz, Christian Steiding, Willi A Kalender
OBJECTIVES: The performance of metal artifact reduction (MAR) methods in x-ray computed tomography (CT) suffers from incorrect identification of metallic implants in the artifact-affected volumetric images. The aim of this study was to investigate potential improvements of state-of-the-art MAR methods by using prior information on geometry and material of the implant. MATERIALS AND METHODS: The influence of a novel prior knowledge-based segmentation (PS) compared with threshold-based segmentation (TS) on 2 MAR methods (linear interpolation [LI] and normalized-MAR [NORMAR]) was investigated...
January 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28106517/traditional-invasive-and-synchrotron-based-non-invasive-assessments-of-3d-printed-hybrid-cartilage-constructs
#17
Adeola Deborah Olubamiji, Ning Zhu, Tuanjie Chang, Chijioke Nwankwo, Zohreh Izadifar, Ali Honaramooz, Daniel Chen, B Frank Eames
Three-dimensional (3D)-printed constructs made of polycaprolactone (PCL) and chondrocyte-impregnated alginate hydrogel (hybrid cartilage constructs) mimic the biphasic nature of articular cartilage, offering promise for cartilage tissue engineering (CTE) applications. However, the regulatory pathway for medical device development requires validation of such constructs through in vitro bench tests and in vivo preclinical examinations premarket approval. Furthermore, non-invasive imaging techniques are required for effective evaluation of the progress of these cartilage constructs, especially when implanted in animal models or human subjects...
January 20, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28106503/ct-and-mri-findings-of-thymic-carcinoid
#18
Aya Shimamoto, Kazuto Ashizawa, Yasuo Kido, Hideyuki Hayashi, Takeshi Nagayasu, Atsushi Kawakami, Hiroshi Mukae, Tomayoshi Hayashi, Mayumi Ohtsubo, Kazuto Shigematsu, Takahiko Nakazono, Hidetake Yabuuchi, Masataka Uetani
OBJECTIVES: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) findings of thymic carcinoid and to compare these findings with previously published findings of thymoma. METHODS: Eleven cases of pathologically proven thymic carcinoid were reviewed retrospectively. Three patients had typical carcinoid and eight patients had atypical carcinoid. The characteristics of the tumours and related thoracic abnormalities were assessed in each case on CT and/or MRI by two chest radiologists...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28106480/radio-pathological-correlation-of-organising-pneumonia-op-a-pictorial-review
#19
Mohammad Zare Mehrjardi, Shahram Kahkouee, Mihan Pourabdollah
Since the description of cryptogenic organising pneumonia (COP) in 1983 by Davison et al. and the subsequent report on bronchiolitis obliterans organising pneumonia (BOOP) by Epler et al., some reports have been published regarding the imaging features of organising pneumonia (OP). In this pictorial review, we aim to describe different manifestations of OP on high-resolution computed tomography (HRCT) accompanied by their histopathological correlations for a better comprehension of the radiological findings pathomechanism...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28106226/applied-taguchi-method-for-fatigue-testing-of-customized-hip-implant
#20
Mangesh R Dharme, Abhaykumar M Kuthe, Tushar R Deshmukh
PURPOSE: Human activities generate stresses, which vary with time and may result in fatigue failure of the customized hip implant. This study aims to investigate fatigue testing of customized hip implants using the minimum number of experiments by the Taguchi method, for 147 patients. This study was also useful to determine the influential geometrical parameters on the fatigue safety factor of customized hip implants. METHODS: Horizontal offset (HO), vertical offset (VO) and neck shaft angle (NSA) of the hip joint of 147 patients were measured on computed tomography (CT) scanned images...
January 20, 2017: International Journal of Artificial Organs
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