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John costello

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https://www.readbyqxmd.com/read/29132713/perioperative-morbidity-of-lymph-node-dissection-for-renal-cell-carcinoma-a-propensity-score-based-analysis
#1
Boris Gershman, Daniel M Moreira, R Houston Thompson, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
BACKGROUND: There are little data regarding the morbidity of lymph node dissection (LND) for renal cell carcinoma (RCC) to assess its risk-benefit ratio. OBJECTIVE: To evaluate the association of LND with 30-d complications among patients undergoing radical nephrectomy (RN) for RCC. DESIGN, SETTING, AND PARTICIPANTS: A total of 2066 patients underwent RN for M0 or M1 RCC between 1990 and 2010, of whom 774 (37%) underwent LND. INTERVENTION: RN with or without LND...
November 10, 2017: European Urology
https://www.readbyqxmd.com/read/29099775/whole-blood-mrna-expression-based-prognosis-of-metastatic-renal-cell-carcinoma
#2
Karthik V Giridhar, Carlos P Sosa, David W Hillman, Cristobal Sanhueza, Candace L Dalpiaz, Brian A Costello, Fernando J Quevedo, Henry C Pitot, Roxana S Dronca, Donna Ertz, John C Cheville, Krishna Vanaja Donkena, Manish Kohli
The Memorial Sloan Kettering Cancer Center (MSKCC) prognostic score is based on clinical parameters. We analyzed whole blood mRNA expression in metastatic clear cell renal cell carcinoma (mCCRCC) patients and compared it to the MSKCC score for predicting overall survival. In a discovery set of 19 patients with mRCC, we performed whole transcriptome RNA sequencing and selected eighteen candidate genes for further evaluation based on associations with overall survival and statistical significance. In an independent validation of set of 47 patients with mCCRCC, transcript expression of the 18 candidate genes were quantified using a customized NanoString probeset...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29082019/antenatal-corticosteroids-for-women-at-risk-of-imminent-preterm-birth-in-low-resource-countries-the-case-for-equipoise-and-the-need-for-efficacy-trials
#3
REVIEW
Joshua P Vogel, Olufemi T Oladapo, Cynthia Pileggi-Castro, Ebunoluwa A Adejuyigbe, Fernando Althabe, Shabina Ariff, Adejumoke Idowu Ayede, Abdullah H Baqui, Anthony Costello, Davy M Chikamata, Caroline Crowther, Bukola Fawole, Luz Gibbons, Alan H Jobe, Monica Lulu Kapasa, John Kinuthia, Alka Kriplani, Oluwafemi Kuti, James Neilson, Janna Patterson, Gilda Piaggio, Rahat Qureshi, Zahida Qureshi, Mari Jeeva Sankar, Jeffrey S A Stringer, Marleen Temmerman, Khalid Yunis, Rajiv Bahl, A Metin Gülmezoglu
The scientific basis for antenatal corticosteroids (ACS) for women at risk of preterm birth has rapidly changed in recent years. Two landmark trials-the Antenatal Corticosteroid Trial and the Antenatal Late Preterm Steroids Trial-have challenged the long-held assumptions on the comparative health benefits and harms regarding the use of ACS for preterm birth across all levels of care and contexts, including resource-limited settings. Researchers, clinicians, programme managers, policymakers and donors working in low-income and middle-income countries now face challenging questions of whether, where and how ACS can be used to optimise outcomes for both women and preterm newborns...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29074501/single-agent-ibrutinib-in-relapsed-or-refractory-follicular-lymphoma-a-phase-2-consortium-trial
#4
Nancy L Bartlett, Brian A Costello, Betsy R LaPlant, Stephen M Ansell, John G Kuruvilla, Craig B Reeder, Lim S Thye, Daniel M Anderson, Kilannin Krysiak, Cody Ramirez, Jing Qi, Barry A Siegel, Malachi Griffith, Obi L Griffith, Felicia Gomez, Todd A Fehniger
Most patients with follicular lymphoma experience multiple relapses necessitating subsequent lines of therapy. Ibrutinib, a Bruton tyrosine kinase inhibitor approved for the treatment of several B-cell malignancies, showed promising activity in follicular lymphoma in a Phase 1 study. We report the results of a Phase 2 trial evaluating ibrutinib in recurrent follicular lymphoma. Forty patients with recurrent follicular lymphoma were treated with ibrutinib, 560 mg/day until progression or intolerance. The primary endpoint was overall response rate...
October 26, 2017: Blood
https://www.readbyqxmd.com/read/29056344/comprehensive-analysis-of-hypermutation-in-human-cancer
#5
Brittany B Campbell, Nicholas Light, David Fabrizio, Matthew Zatzman, Fabio Fuligni, Richard de Borja, Scott Davidson, Melissa Edwards, Julia A Elvin, Karl P Hodel, Walter J Zahurancik, Zucai Suo, Tatiana Lipman, Katharina Wimmer, Christian P Kratz, Daniel C Bowers, Theodore W Laetsch, Gavin P Dunn, Tanner M Johanns, Matthew R Grimmer, Ivan V Smirnov, Valérie Larouche, David Samuel, Annika Bronsema, Michael Osborn, Duncan Stearns, Pichai Raman, Kristina A Cole, Phillip B Storm, Michal Yalon, Enrico Opocher, Gary Mason, Gregory A Thomas, Magnus Sabel, Ben George, David S Ziegler, Scott Lindhorst, Vanan Magimairajan Issai, Shlomi Constantini, Helen Toledano, Ronit Elhasid, Roula Farah, Rina Dvir, Peter Dirks, Annie Huang, Melissa A Galati, Jiil Chung, Vijay Ramaswamy, Meredith S Irwin, Melyssa Aronson, Carol Durno, Michael D Taylor, Gideon Rechavi, John M Maris, Eric Bouffet, Cynthia Hawkins, Joseph F Costello, M Stephen Meyn, Zachary F Pursell, David Malkin, Uri Tabori, Adam Shlien
We present an extensive assessment of mutation burden through sequencing analysis of >81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associated with high mutation burden. Replication repair deficiency was a major contributing factor. We uncovered new driver mutations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite instability and replication repair deficiency on the scale of mutation load...
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29033190/3d-modelling-of-radical-prostatectomy-specimens-developing-a-method-to-quantify-tumor-morphometry-for-prostate-cancer-risk-prediction
#6
Marcus C Hovens, Kevin Lo, Michael Kerger, John Pedersen, Timothy Nottle, Natalie Kurganovs, Andrew Ryan, Justin S Peters, Daniel Moon, Anthony J Costello, Niall M Corcoran, Matthew K H Hong
Prostate cancer displays a wide spectrum of clinical behaviour from biological indolence to rapidly lethal disease, but we remain unable to accurately predict an individual tumor's future clinical course at an early curable stage. Beyond basic dimensions and volume calculations, tumor morphometry is an area that has received little attention, as it requires the analysis of the prostate gland and tumor foci in three-dimensions. Previous efforts to generate three-dimensional prostate models have required specialised graphics units and focused on the spatial distribution of tumors for optimisation of biopsy strategies rather than to generate novel morphometric variables such as tumor surface area...
September 27, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28987397/duration-of-postoperative-mechanical-ventilation-as-a-quality-metric-for-pediatric-cardiac-surgical-programs
#7
Michael Gaies, David K Werho, Wenying Zhang, Janet E Donohue, Sarah Tabbutt, Nancy S Ghanayem, Mark A Scheurer, John M Costello, J William Gaynor, Sara K Pasquali, Justin B Dimick, Mousumi Banerjee, Steven M Schwartz
BACKGROUND: Few metrics exist to assess quality of care at pediatric cardiac surgical programs, limiting opportunities for benchmarking and quality improvement. Postoperative duration of mechanical ventilation (POMV) may be an important quality metric because of its association with complications and resource utilization. In this study we modelled case-mix-adjusted POMV duration and explored hospital performance across POMV metrics. METHODS: This study used the Pediatric Cardiac Critical Care Consortium clinical registry to analyze 4,739 hospitalizations from 15 hospitals (October 2013 to August 2015)...
October 4, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28985418/the-systemhc-atlas-project
#8
Wenguang Shao, Patrick G A Pedrioli, Witold Wolski, Cristian Scurtescu, Emanuel Schmid, Juan A Vizcaíno, Mathieu Courcelles, Heiko Schuster, Daniel Kowalewski, Fabio Marino, Cecilia S L Arlehamn, Kerrie Vaughan, Bjoern Peters, Alessandro Sette, Tom H M Ottenhoff, Krista E Meijgaarden, Natalie Nieuwenhuizen, Stefan H E Kaufmann, Ralph Schlapbach, John C Castle, Alexey I Nesvizhskii, Morten Nielsen, Eric W Deutsch, David S Campbell, Robert L Moritz, Roman A Zubarev, Anders Jimmy Ytterberg, Anthony W Purcell, Miguel Marcilla, Alberto Paradela, Qi Wang, Catherine E Costello, Nicola Ternette, Peter A van Veelen, Cécile A C M van Els, Albert J R Heck, Gustavo A de Souza, Ludvig M Sollid, Arie Admon, Stefan Stevanovic, Hans-Georg Rammensee, Pierre Thibault, Claude Perreault, Michal Bassani-Sternberg, Ruedi Aebersold, Etienne Caron
Mass spectrometry (MS)-based immunopeptidomics investigates the repertoire of peptides presented at the cell surface by major histocompatibility complex (MHC) molecules. The broad clinical relevance of MHC-associated peptides, e.g. in precision medicine, provides a strong rationale for the large-scale generation of immunopeptidomic datasets and recent developments in MS-based peptide analysis technologies now support the generation of the required data. Importantly, the availability of diverse immunopeptidomic datasets has resulted in an increasing need to standardize, store and exchange this type of data to enable better collaborations among researchers, to advance the field more efficiently and to establish quality measures required for the meaningful comparison of datasets...
July 29, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28983920/transcriptional-variations-in-the-wider-peritumoral-tissue-environment-of-pancreatic-cancer
#9
Andrea S Bauer, Petr V Nazarov, Nathalia A Giese, Stefania Beghelli, Anette Heller, William Greenhalf, Eithne Costello, Arnaud Muller, Melanie Bier, Oliver Strobel, Thilo Hackert, Laurent Vallar, Aldo Scarpa, Markus W Büchler, John P Neoptolemos, Stephanie Kreis, Jörg D Hoheisel
Transcriptional profiling was performed on 452 RNA preparations isolated from various types of pancreatic tissue from tumour patients and healthy donors, with a particular focus on peritumoral samples. Pancreatic ductal adenocarcinomas (PDAC) and cystic tumours were most different in these non-tumorous tissues surrounding them, whereas the actual tumours exhibited rather similar transcript patterns. The environment of cystic tumours was transcriptionally nearly identical to normal pancreas tissue. In contrast, the tissue around PDAC behaved a lot like the tumour, indicating some kind of field defect, while showing far less molecular resemblance to both chronic pancreatitis and healthy tissue...
October 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28970586/microscale-bioreactors-for-in-situ-characterization-of-gi-epithelial-cell-physiology
#10
Cait M Costello, Mikkel B Phillipsen, Leonard M Hartmanis, Marek A Kwasnica, Victor Chen, David Hackam, Matthew W Chang, William E Bentley, John C March
The development of in vitro artificial small intestines that realistically mimic in vivo systems will enable vast improvement of our understanding of the human gut and its impact on human health. Synthetic in vitro models can control specific parameters, including (but not limited to) cell types, fluid flow, nutrient profiles and gaseous exchange. They are also "open" systems, enabling access to chemical and physiological information. In this work, we demonstrate the importance of gut surface topography and fluid flow dynamics which are shown to impact epithelial cell growth, proliferation and intestinal cell function...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28947870/low-hypoxia-inducible-factor-1%C3%AE-hif-1%C3%AE-expression-in-testicular-germ-cell-tumors-a-major-reason-for-enhanced-chemosensitivity
#11
Niraj Shenoy, Roxana Dronca, Fernando Quevedo, Stephen A Boorjian, John Cheville, Brian Costello, Manish Kohli, Thomas Witzig, Lance Pagliaro
The molecular basis for enhanced chemosensitivity of testicular germ cell tumors (GCT) has been an area of great interest, as it could potentially give us therapeutic leads in other resistant malignancies. Thus far, however, the increased sensitivity of GCT has been variously attributed to multiple factors - an inability to detoxify cisplatin, a lack of export pumps, an inability to repair the DNA damage, an intact apoptotic cascade and lack of p53 mutation; but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive...
August 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28933996/research-roundup
#12
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
September 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28928879/-18-f-fdg-pet-ct-as-an-indicator-of-survival-in-ewing-sarcoma-of-bone
#13
Usama Salem, Behrang Amini, Hubert H Chuang, Najat C Daw, Wei Wei, Tamara Miner Haygood, John E Madewell, Colleen M Costelloe
Objective: The existing literature of 18 F-FDG PET/CT in Ewing sarcoma investigates mixed populations of patients with both soft tissue and bone primary tumors. The aim of our study was to evaluate whether the maximum standardized uptake value (SUVmax) obtained with 18F-FDG PET/CT before and after induction chemotherapy can be used as an indicator of survival in patients with Ewing sarcoma originating exclusively in the skeleton. Materials and Methods: A retrospective database search from 2004-2011 identified 28 patients who underwent 18 F-FDG PET/CT before (SUV1, n= 28) and after (SUV2, n=23) induction chemotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28892836/repurposing-consumer-products-as-a-gateway-to-just-in-time-communication
#14
Amanda O'Brien, Meghan O'Brien, Ralf W Schlosser, Christina Yu, Anna A Allen, Suzanne Flynn, John Costello, Howard C Shane
No abstract text is available yet for this article.
September 2017: Seminars in Speech and Language
https://www.readbyqxmd.com/read/28854052/research-roundup
#15
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
August 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28792526/cryptosporidium-parvum-vaccine-candidates-are-incompletely-modified-with-o-linked-n-acetylgalactosamine-or-contain-n-terminal-n-myristate-and-s-palmitate
#16
John R Haserick, Joshua A Klein, Catherine E Costello, John Samuelson
Cryptosporidium parvum (studied here) and Cryptosporidium hominis are important causes of diarrhea in infants and immunosuppressed persons. C. parvum vaccine candidates, which are on the surface of sporozoites, include glycoproteins with Ser- and Thr-rich domains (Gp15, Gp40, and Gp900) and a low complexity, acidic protein (Cp23). Here we used mass spectrometry to determine that O-linked GalNAc is present in dense arrays on a glycopeptide with consecutive Ser derived from Gp40 and on glycopeptides with consecutive Thr derived from Gp20, a novel C...
2017: PloS One
https://www.readbyqxmd.com/read/28790138/amifostine-does-not-protect-thyroid-cancer-cells-in-dna-damaging-in-vitro-models
#17
Joanna Klubo-Gwiezdzinska, John Costello, Kirk Jensen, Aneeta Patel, Rok Tkavc, Douglas Van Nostrand, Kenneth D Burman, Leonard Wartofsky, Vasyl Vasko
BACKGROUND: Amifostine is a potent scavenger of reactive oxygen species that is used for the salivary gland protection during therapy with radioactive iodine for thyroid cancer. There are no data on the potential effect of amifostine on thyroid cancer cells. METHODS: We investigated the effects of the active form of amifostine (WR-1065) on the response of thyroid cancer cells to treatment with DNA-damaging agents. WR-1065 was examined in human thyroid cancer cell lines (FTC133, TPC1, BCPAP and C643) and embryonic fibroblast cells NIH3T3...
October 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28765340/lack-of-association-for-reported-endocrine-pancreatic-cancer-risk-loci-in-the-pandora-consortium
#18
Daniele Campa, Ofure Obazee, Manuela Pastore, Francesco Panzuto, Valbona Liço, William Greenhalf, Verena Katzke, Francesca Tavano, Eithne Costello, Vincenzo Corbo, Renata Talar-Wojnarowska, Oliver Strobel, Carlo Federico Zambon, John P Neoptolemos, Giulia Zerboni, Rudolf Kaaks, Timothy J Key, Carlo Lombardo, Krzysztof Jamroziak, Domenica Gioffreda, Thilo Hackert, Kay-Tee Khaw, Stefano Landi, Anna Caterina Milanetto, Luca Landoni, Rita T Lawlor, Franco Bambi, Felice Pirozzi, Daniela Basso, Claudio Pasquali, Gabriele Capurso, Federico Canzian
Background: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms for which very little is known about either environmental or genetic risk factors. Only a handful of association studies have been performed so far, suggesting a small number of risk loci.Methods: To replicate the best findings, we have selected 16 SNPs suggested in previous studies to be relevant in PNET etiogenesis. We genotyped the selected SNPs (rs16944, rs1052536, rs1059293, rs1136410, rs1143634, rs2069762, rs2236302, rs2387632, rs3212961, rs3734299, rs3803258, rs4962081, rs7234941, rs7243091, rs12957119, and rs1800629) in 344 PNET sporadic cases and 2,721 controls in the context of the PANcreatic Disease ReseArch (PANDoRA) consortium...
August 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28756749/research-roundup
#19
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
July 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28742724/epidemiology-of-noninvasive-ventilation-in-pediatric-cardiac-icus
#20
Ryan A Romans, Steven M Schwartz, John M Costello, Nikhil K Chanani, Parthak Prodhan, Avihu Z Gazit, Andrew H Smith, David S Cooper, Jeffrey Alten, Kshitij P Mistry, Wenying Zhang, Janet E Donohue, Michael Gaies
OBJECTIVE: To describe the epidemiology of noninvasive ventilation therapy for patients admitted to pediatric cardiac ICUs and to assess practice variation across hospitals. DESIGN: Retrospective cohort study using prospectively collected clinical registry data. SETTING: Pediatric Cardiac Critical Care Consortium clinical registry. PATIENTS: Patients admitted to cardiac ICUs at PC4 hospitals. INTERVENTIONS: None...
October 2017: Pediatric Critical Care Medicine
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