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John costello

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https://www.readbyqxmd.com/read/27930909/fda-regulation-of-neurological-and-physical-medicine-devices-access-to-safe-and-effective-neurotechnologies-for-all-americans
#1
Leigh Anderson, Patrick Antkowiak, Aden Asefa, Amber Ballard, Tushar Bansal, Ayo Bello, Bernard Berne, Kristen Bowsher, Bennett Blumenkopf, Ian Broverman, Mohamad Bydon, Kuo Chao, Peter Como, Karlene Cork, Ann Costello, Kathryn De Laurentis, Angela DeMarco, Heather Dean, John Doucet, Bradley Dworak, Lisa Epperson, Eric Franca, Naz Ghassemian, Chandramallika Ghosh, Anupama Govindarajan, Jay Gupta, Stacie Gutowski, Robert Herrmann, Michael Hoffmann, William Heetderks, Steven Hsu, Daryl Kaufman, Erin Keegan, Gregg Kittlesen, Kevin Khuu, Hyung Lee, Larry Lo, Ian Marcus, Timothy Marjenin, Binoy Mathews, Sanjay Misra, Vivek Pinto, Vesper Ramos, Samuel Raben, Avena Russell, Devjani Saha, Joonil Seog, Christian Shenouda, Myra Smith, Xiaorui Tang, Kelliann Wachrathit, Jaime Waterhouse, Dhanya Williams, Xiaolin Zheng, Carlos Peña
The United States Food and Drug Administration (FDA) ensures that patients in the U.S. have access to safe and effective medical devices. The Division of Neurological and Physical Medicine Devices reviews medical technologies that interface with the nervous system. This article addresses how to navigate the FDA's regulatory landscape to successfully bring medical devices to patients.
December 7, 2016: Neuron
https://www.readbyqxmd.com/read/27893535/cytoplasmic-hur-status-predicts-disease-free-survival-in-resected-pancreatic-cancer-a-post-hoc-analysis-from-the-international-phase-iii-espac-3-clinical-trial
#2
Talar Tatarian, Wei Jiang, Benjamin E Leiby, Amanda Grigoli, Masaya Jimbo, Nooreen Dabbish, John P Neoptolemos, William Greenhalf, Eithne Costello, Paula Ghaneh, Christopher Halloran, Daniel Palmer, Markus Buchler, Charles J Yeo, Jordan M Winter, Jonathan R Brody
OBJECTIVES: We tested cytoplasmic HuR (cHuR) as a predictive marker for response to chemotherapy by examining tumor samples from the international European Study Group of Pancreatic Cancer-3 trial, in which patients with resected pancreatic ductal adenocarcinoma (PDA) received either gemcitabine (GEM) or 5-fluorouracil (5-FU) adjuvant monotherapy. BACKGROUND: Previous studies have implicated the mRNA-binding protein, HuR (ELAVL1), as a predictive marker for PDA treatment response in the adjuvant setting...
November 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27885909/research-roundup
#3
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
November 2, 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27849774/130-glucocorticoid-receptor-profiles-in-children-undergoing-cardiopulmonary-bypass
#4
Vishal Gunnala, Nga Du, Emily Petersen, Hannah Palac, John Costello, Carl Backer, Conrad Epting, Eric Wald
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849769/125-multicenter-validation-of-the-vasoactive-ventilation-renal-score-for-neonatal-cardiac-surgery
#5
Christopher Mastropietro, Katherine Cashen, Keshava Murthy Narayana Gowda, Kurt Piggott, Michael Wilhelm, John Costello
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27826709/risk-factors-for-cardiac-arrest-or-mechanical-circulatory-support-in-children-with-fulminant-myocarditis
#6
Joseph R Casadonte, Mjaye L Mazwi, Katheryn E Gambetta, Hannah L Palac, Mary E McBride, Osama M Eltayeb, Michael C Monge, Carl L Backer, John M Costello
In children with fulminant myocarditis (FM), we sought to describe presenting characteristics and clinical outcomes, and identify risk factors for cardiac arrest and mechanical circulatory support (MCS). A retrospective review of patients with FM admitted at our institution between January 1, 2004, and June 31, 2015, was performed. We compared characteristics and outcomes of FM patients who received cardiopulmonary resuscitation (CPR) and/or were placed on MCS (CPR/MCS group) to those who did not develop these outcomes (Control group)...
November 8, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27802086/research-roundup
#7
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
October 2, 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27796362/reconstituted-b-cell-receptor-signaling-reveals-carbohydrate-dependent-mode-of-activation
#8
Rina F Villar, Jinal Patel, Grant C Weaver, Masaru Kanekiyo, Adam K Wheatley, Hadi M Yassine, Catherine E Costello, Kevin B Chandler, Patrick M McTamney, Gary J Nabel, Adrian B McDermott, John R Mascola, Steven A Carr, Daniel Lingwood
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B cell receptor (BCR) activation modality that proceeded through non-cognate interactions with antigen. Using a new approach to reconstitute antigen-receptor interactions in a human reporter B cell line, we found that sequence-defined BCRs from the human germline repertoire could be triggered by both complementarity to influenza HA and a separate mode of signaling that relied on multivalent ligation of BCR sialyl-oligosaccharide...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768182/association-of-distinct-mutational-signatures-with-correlates-of-increased-immune-activity-in-pancreatic-ductal-adenocarcinoma
#9
Ashton A Connor, Robert E Denroche, Gun Ho Jang, Lee Timms, Sangeetha N Kalimuthu, Iris Selander, Treasa McPherson, Gavin W Wilson, Michelle A Chan-Seng-Yue, Ivan Borozan, Vincent Ferretti, Robert C Grant, Ilinca M Lungu, Eithne Costello, William Greenhalf, Daniel Palmer, Paula Ghaneh, John P Neoptolemos, Markus Buchler, Gloria Petersen, Sarah Thayer, Michael A Hollingsworth, Alana Sherker, Daniel Durocher, Neesha Dhani, David Hedley, Stefano Serra, Aaron Pollett, Michael H A Roehrl, Prashant Bavi, John M S Bartlett, Sean Cleary, Julie M Wilson, Ludmil B Alexandrov, Malcolm Moore, Bradly G Wouters, John D McPherson, Faiyaz Notta, Lincoln D Stein, Steven Gallinger
Importance: Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. Advances in next-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step toward personalized treatment strategies for this disease. Objective: To classify PDAC according to distinct mutational processes, and explore their clinical significance. Design, Setting, and Participants: We performed a retrospective cohort study of resected PDAC, using cases collected between 2008 and 2015 as part of the International Cancer Genome Consortium...
October 20, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27714914/a-pilot-study-of-potential-brain-donor-satisfaction-and-attitudes-towards-telephone-assessment
#10
Helen Costello, Gillian M Hayes, Elizabeth Highton-Williamson, Shirley Nurock, Dave Hanbury, Paul T Francis
OBJECTIVE: Test the feasibility of assessing cognition, psychiatric symptoms and daily living skills of potential brain donors by telephone and compare satisfaction and attitudes across telephone and face-to-face assessment. METHOD: Data were collected from 108 healthy participants from the Brains for Dementia Research cohort. Purposive sampling was used to assess feasibility and a randomised control trial design compared satisfaction and attitudes towards telephone and face-to-face assessment...
October 7, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27671144/radical-nephrectomy-with-or-without-lymph-node-dissection-for-nonmetastatic-renal-cell-carcinoma-a-propensity-score-based-analysis
#11
Boris Gershman, R Houston Thompson, Daniel M Moreira, Stephen A Boorjian, Matthew K Tollefson, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
BACKGROUND: It is uncertain whether lymph node dissection (LND) provides a therapeutic benefit in renal cell carcinoma (RCC). OBJECTIVE: To evaluate the association of LND with oncologic outcomes among patients undergoing radical nephrectomy (RN) for nonmetastatic RCC. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study of 1797 patients treated with RN for M0 RCC between 1990 and 2010, including 606 (34%) who underwent LND. INTERVENTION: RN with or without LND...
September 23, 2016: European Urology
https://www.readbyqxmd.com/read/27666308/research-roundup
#12
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
September 2, 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27663739/o-fucosylated-glycoproteins-form-assemblies-in-close-proximity-to-the-nuclear-pore-complexes-of-toxoplasma-gondii
#13
Giulia Bandini, John R Haserick, Edwin Motari, Dinkorma T Ouologuem, Sebastian Lourido, David S Roos, Catherine E Costello, Phillips W Robbins, John Samuelson
Toxoplasma gondii is an intracellular parasite that causes disseminated infections in fetuses and immunocompromised individuals. Although gene regulation is important for parasite differentiation and pathogenesis, little is known about protein organization in the nucleus. Here we show that the fucose-binding Aleuria aurantia lectin (AAL) binds to numerous punctate structures in the nuclei of tachyzoites, bradyzoites, and sporozoites but not oocysts. AAL also binds to Hammondia and Neospora nuclei but not to more distantly related apicomplexans...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27663461/lymph-node-dissection-is-not-associated-with-improved-survival-among-patients-undergoing-cytoreductive-nephrectomy-for-metastatic-renal-cell-carcinoma-a-propensity-score-based-analysis
#14
Boris Gershman, R Houston Thompson, Daniel M Moreira, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
PURPOSE: The oncologic benefit of lymph node dissection for patients undergoing cytoreductive nephrectomy for metastatic renal cell carcinoma is uncertain. Therefore, we evaluated the association of lymph node dissection with oncologic outcomes among patients undergoing cytoreductive nephrectomy. MATERIALS AND METHODS: We identified 305 patients treated with cytoreductive nephrectomy for metastatic renal cell carcinoma between 1990 and 2010, of whom 188 (62%) underwent lymph node dissection...
September 20, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27625333/extracorporeal-membrane-oxygenation-outcomes-in-children-with-hemophagocytic-lymphohistiocytosis
#15
Katherine Cashen, Roland L Chu, Justin Klein, Peter T Rycus, John M Costello
INTRODUCTION: Pediatric patients with hemophagocytic lymphohistiocytosis (HLH) may develop refractory respiratory or cardiac failure that warrants consideration for extracorporeal membrane oxygenation (ECMO) support. The purposes of this study were to describe the use and outcomes of ECMO in pediatric HLH patients, to identify risk factors for hospital mortality and to compare their ECMO use and outcomes to the ECMO population as a whole. METHODS: Pediatric patients (⩽ 18 years) with a diagnosis of HLH in the Extracorporeal Life Support Organization (ELSO) Registry were included...
September 13, 2016: Perfusion
https://www.readbyqxmd.com/read/27587321/irregular-and-ineffective-a-quantitative-observational-study-of-the-time-and-technique-of-inhaler-use
#16
Imran Sulaiman, Jansen Seheult, Elaine MacHale, Shona D'Arcy, Fiona Boland, Katrina McCrory, John Casey, Gerard Bury, Mazen Al-Alawi, Susan O'Dwyer, Sheila A Ryder, Richard B Reilly, Richard W Costello
BACKGROUND: Cross-sectional observational studies suggest that between 50% and 60% of patients misuse a dry powder inhaler, whereas studies with electronic monitors indicate that patients sometimes overuse/underuse their inhalers. It is not known what impact errors and erratic use have on inhaler adherence. OBJECTIVES: The purpose of this study was to longitudinally quantify when and how patients adhered to a twice-daily preventer treatment by using a novel acoustic recording device attached to an inhaler (INhaler Compliance Assessment)...
September 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27584663/the-impact-of-diabetes-mellitus-on-survival-following-resection-and-adjuvant-chemotherapy-for-pancreatic-cancer
#17
Jörg Kleeff, Eithne Costello, Richard Jackson, Chris Halloran, William Greenhalf, Paula Ghaneh, Richard F Lamb, Markus M Lerch, Julia Mayerle, Daniel Palmer, Trevor Cox, Charlotte L Rawcliffe, Oliver Strobel, Markus W Büchler, John P Neoptolemos
BACKGROUND: Diabetes mellitus is frequently observed in pancreatic cancer patients and is both a risk factor and an early manifestation of the disease. METHODS: We analysed the prognostic impact of diabetes on the outcome of pancreatic cancer following resection and adjuvant chemotherapy using individual patient data from three European Study Group for Pancreatic Cancer randomised controlled trials. Analyses were carried out to assess the association between clinical characteristics and the presence of preoperative diabetes, as well as the effect of diabetic status on overall survival...
September 27, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27580831/qualitative-investigation-into-a-wearable-system-for-chronic-obstructive-pulmonary-disease-the-stakeholders-perspective
#18
Reem Kayyali, Vilius Savickas, Martijn A Spruit, Evangelos Kaimakamis, Roshan Siva, Richard W Costello, John Chang, Barbara Pierscionek, Nikki Davies, Anouk W Vaes, Rita Paradiso, Nada Philip, Eleni Perantoni, Shona D'Arcy, Andreas Raptopoulos, Shereen Nabhani-Gebara
OBJECTIVES: To ascertain the stakeholders' views and devise recommendations for further stages of the Wearable Sensing and Smart Cloud Computing for Integrated Care to Chronic Obstructive Pulmonary Disease (COPD) Patients with Co-morbidities (WELCOME) system development. This system aims to create a wearable vest to monitor physiological signals for patients concerned incorporating an inhaler adherence monitoring, weight, temperature, blood pressure and glucose metres, and a mobile health application for communication with healthcare professionals (HCPs)...
2016: BMJ Open
https://www.readbyqxmd.com/read/27578530/expression-of-drd2-is-increased-in-human-pancreatic-ductal-adenocarcinoma-and-inhibitors-slow-tumor-growth-in-mice
#19
Pouria Jandaghi, Hamed S Najafabadi, Andrea S Bauer, Andreas I Papadakis, Matteo Fassan, Anita Hall, Anie Monast, Magnus von Knebel Doeberitz, John P Neoptolemos, Eithne Costello, William Greenhalf, Aldo Scarpa, Bence Sipos, Daniel Auld, Mark Lathrop, Morag Park, Markus W Büchler, Oliver Strobel, Thilo Hackert, Nathalia A Giese, George Zogopoulos, Veena Sangwan, Sidong Huang, Yasser Riazalhosseini, Jörg D Hoheisel
BACKGROUND & AIMS: Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, are almost equivalent, so better treatments are needed. We studied gene expression profiles of PDACs and the functions of genes with altered expression to identify new therapeutic targets. METHODS: We performed microarray analysis to analyze gene expression profiles of 195 PDAC and 41 non-tumor pancreatic tissue samples. We undertook an extensive analysis of the PDAC transcriptome by superimposing interaction networks of proteins encoded by aberrantly expressed genes over signaling pathways associated with PDAC development to identify factors that might alter regulation of these pathways during tumor progression...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27568781/research-roundup
#20
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
August 2016: International Journal of Palliative Nursing
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