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John costello

Ashton A Connor, Robert E Denroche, Gun Ho Jang, Lee Timms, Sangeetha N Kalimuthu, Iris Selander, Treasa McPherson, Gavin W Wilson, Michelle A Chan-Seng-Yue, Ivan Borozan, Vincent Ferretti, Robert C Grant, Ilinca M Lungu, Eithne Costello, William Greenhalf, Daniel Palmer, Paula Ghaneh, John P Neoptolemos, Markus Buchler, Gloria Petersen, Sarah Thayer, Michael A Hollingsworth, Alana Sherker, Daniel Durocher, Neesha Dhani, David Hedley, Stefano Serra, Aaron Pollett, Michael H A Roehrl, Prashant Bavi, John M S Bartlett, Sean Cleary, Julie M Wilson, Ludmil B Alexandrov, Malcolm Moore, Bradly G Wouters, John D McPherson, Faiyaz Notta, Lincoln D Stein, Steven Gallinger
Importance: Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. Advances in next-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step toward personalized treatment strategies for this disease. Objective: To classify PDAC according to distinct mutational processes, and explore their clinical significance. Design, Setting, and Participants: We performed a retrospective cohort study of resected PDAC, using cases collected between 2008 and 2015 as part of the International Cancer Genome Consortium...
October 20, 2016: JAMA Oncology
Helen Costello, Gillian M Hayes, Elizabeth Highton-Williamson, Shirley Nurock, Dave Hanbury, Paul T Francis
OBJECTIVE: Test the feasibility of assessing cognition, psychiatric symptoms and daily living skills of potential brain donors by telephone and compare satisfaction and attitudes across telephone and face-to-face assessment. METHOD: Data were collected from 108 healthy participants from the Brains for Dementia Research cohort. Purposive sampling was used to assess feasibility and a randomised control trial design compared satisfaction and attitudes towards telephone and face-to-face assessment...
October 7, 2016: International Journal of Geriatric Psychiatry
Boris Gershman, R Houston Thompson, Daniel M Moreira, Stephen A Boorjian, Matthew K Tollefson, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
BACKGROUND: It is uncertain whether lymph node dissection (LND) provides a therapeutic benefit in renal cell carcinoma (RCC). OBJECTIVE: To evaluate the association of LND with oncologic outcomes among patients undergoing radical nephrectomy (RN) for nonmetastatic RCC. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study of 1797 patients treated with RN for M0 RCC between 1990 and 2010, including 606 (34%) who underwent LND. INTERVENTION: RN with or without LND...
September 23, 2016: European Urology
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
September 2, 2016: International Journal of Palliative Nursing
Giulia Bandini, John R Haserick, Edwin Motari, Dinkorma T Ouologuem, Sebastian Lourido, David S Roos, Catherine E Costello, Phillips W Robbins, John Samuelson
Toxoplasma gondii is an intracellular parasite that causes disseminated infections in fetuses and immunocompromised individuals. Although gene regulation is important for parasite differentiation and pathogenesis, little is known about protein organization in the nucleus. Here we show that the fucose-binding Aleuria aurantia lectin (AAL) binds to numerous punctate structures in the nuclei of tachyzoites, bradyzoites, and sporozoites but not oocysts. AAL also binds to Hammondia and Neospora nuclei but not to more distantly related apicomplexans...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Boris Gershman, R Houston Thompson, Daniel M Moreira, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
PURPOSE: The oncologic benefit of lymph node dissection (LND) for patients undergoing cytoreductive nephrectomy (CN) for metastatic renal cell carcinoma (mRCC) is uncertain. We evaluated the association of LND with oncologic outcomes among patients undergoing CN. MATERIALS AND METHODS: We identified 305 patients treated with CN for mRCC between 1990 and 2010, of whom 188 (62%) underwent LND. Several propensity-score techniques were used to evaluate cancer-specific (CSM) and all-cause mortality (ACM)...
September 20, 2016: Journal of Urology
Katherine Cashen, Roland L Chu, Justin Klein, Peter T Rycus, John M Costello
INTRODUCTION: Pediatric patients with hemophagocytic lymphohistiocytosis (HLH) may develop refractory respiratory or cardiac failure that warrants consideration for extracorporeal membrane oxygenation (ECMO) support. The purposes of this study were to describe the use and outcomes of ECMO in pediatric HLH patients, to identify risk factors for hospital mortality and to compare their ECMO use and outcomes to the ECMO population as a whole. METHODS: Pediatric patients (⩽ 18 years) with a diagnosis of HLH in the Extracorporeal Life Support Organization (ELSO) Registry were included...
September 13, 2016: Perfusion
Imran Sulaiman, Jansen Seheult, Elaine MacHale, Shona D'Arcy, Fiona Boland, Katrina McCrory, John Casey, Gerard Bury, Mazen Al-Alawi, Susan O'Dwyer, Sheila A Ryder, Richard B Reilly, Richard W Costello
BACKGROUND: Cross-sectional observational studies suggest that between 50% and 60% of patients misuse a dry powder inhaler, whereas studies with electronic monitors indicate that patients sometimes overuse/underuse their inhalers. It is not known what impact errors and erratic use have on inhaler adherence. OBJECTIVES: The purpose of this study was to longitudinally quantify when and how patients adhered to a twice-daily preventer treatment by using a novel acoustic recording device attached to an inhaler (INhaler Compliance Assessment)...
September 2016: Journal of Allergy and Clinical Immunology in Practice
Jörg Kleeff, Eithne Costello, Richard Jackson, Chris Halloran, William Greenhalf, Paula Ghaneh, Richard F Lamb, Markus M Lerch, Julia Mayerle, Daniel Palmer, Trevor Cox, Charlotte L Rawcliffe, Oliver Strobel, Markus W Büchler, John P Neoptolemos
BACKGROUND: Diabetes mellitus is frequently observed in pancreatic cancer patients and is both a risk factor and an early manifestation of the disease. METHODS: We analysed the prognostic impact of diabetes on the outcome of pancreatic cancer following resection and adjuvant chemotherapy using individual patient data from three European Study Group for Pancreatic Cancer randomised controlled trials. Analyses were carried out to assess the association between clinical characteristics and the presence of preoperative diabetes, as well as the effect of diabetic status on overall survival...
September 27, 2016: British Journal of Cancer
Reem Kayyali, Vilius Savickas, Martijn A Spruit, Evangelos Kaimakamis, Roshan Siva, Richard W Costello, John Chang, Barbara Pierscionek, Nikki Davies, Anouk W Vaes, Rita Paradiso, Nada Philip, Eleni Perantoni, Shona D'Arcy, Andreas Raptopoulos, Shereen Nabhani-Gebara
OBJECTIVES: To ascertain the stakeholders' views and devise recommendations for further stages of the Wearable Sensing and Smart Cloud Computing for Integrated Care to Chronic Obstructive Pulmonary Disease (COPD) Patients with Co-morbidities (WELCOME) system development. This system aims to create a wearable vest to monitor physiological signals for patients concerned incorporating an inhaler adherence monitoring, weight, temperature, blood pressure and glucose metres, and a mobile health application for communication with healthcare professionals (HCPs)...
2016: BMJ Open
Pouria Jandaghi, Hamed S Najafabadi, Andrea S Bauer, Andreas I Papadakis, Matteo Fassan, Anita Hall, Anie Monast, Magnus von Knebel Doeberitz, John P Neoptolemos, Eithne Costello, William Greenhalf, Aldo Scarpa, Bence Sipos, Daniel Auld, Mark Lathrop, Morag Park, Markus W Büchler, Oliver Strobel, Thilo Hackert, Nathalia A Giese, George Zogopoulos, Veena Sangwan, Sidong Huang, Yasser Riazalhosseini, Jörg D Hoheisel
BACKGROUND & AIMS: Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, are almost equivalent, so better treatments are needed. We studied gene expression profiles of PDACs and the functions of genes with altered expression to identify new therapeutic targets. METHODS: We performed microarray analysis to analyze gene expression profiles of 195 PDAC and 41 non-tumor pancreatic tissue samples. We undertook an extensive analysis of PDAC transcriptome by superimposing interaction networks of proteins encoded by aberrantly expressed genes over signaling pathways associated with PDAC development to identify factors that might alter regulation of these pathways during tumor progression...
August 28, 2016: Gastroenterology
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
August 2016: International Journal of Palliative Nursing
Daniel D Joyce, Sarah P Psutka, Ryan T Groeschl, R Houston Thompson, Stephen A Boorjian, John C Cheville, Suzanne B Stewart-Merrill, Christine M Lohse, Brian A Costello, Florencia G Que, Bradley C Leibovich
OBJECTIVES: To assess the safety and utility of more aggressive surgical resection of renal cell carcinoma (RCC) involving the liver at the time of nephrectomy. METHODS: We identified 34 cases at our institution where patients underwent simultaneous nephrectomy and hepatic resection for direct hepatic invasion (n=17) or metastatic RCC (n=21). Perioperative outcomes and complication rates were compared to a matched referent cohort (n=68) undergoing simultaneous nephrectomy and resection of non-hepatic locally invasive/metastatic disease...
August 17, 2016: Urology
Mark P Mooney, Jocelyn M Shand, Anne Burrows, Timothy D Smith, John F Caccamese, Gregory M Cooper, James J Cray, James Gilbert, Bernard J Costello, Joseph E Losee, Amr M Moursi, Michael I Siegel
OBJECTIVES:   An overexpression of Tgf-β2 leads to calvarial hyperostosis and suture fusion in individuals with craniosynostosis. Inhibition of Tgf-β2 may help rescue fusing sutures and restore normal growth. The present study was designed to test this hypothesis. DESIGN:   Twenty-eight New Zealand White rabbits with delayed-onset coronal synostosis had radiopaque markers placed on either side of the coronal sutures at 10 days of age. The rabbits were randomly assigned to: (1) sham control rabbits (n = 10), (2) rabbits with control IgG (100 μg/suture) delivered in a collagen vehicle (n = 9), and (3) rabbits with Tgf-β2 neutralizing antibody (100 μg/suture) delivered in a collagen vehicle (n = 9)...
August 9, 2016: Cleft Palate-craniofacial Journal
Carl L Backer, Osama Eltayeb, Michael C Mongé, Mjaye L Mazwi, John M Costello
OBJECTIVES: This review summarizes the current understanding of the pathophysiology and perioperative management of patent ductus arteriosus, atrial septal defect, ventricular septal defect, and atrioventricular septal defect. DATA SOURCE: MEDLINE and PubMed. CONCLUSIONS: The four congenital cardiac lesions that are the subject of this review, patent ductus arteriosus, atrial septal defect, ventricular septal defect, and atrioventricular septal defect, are the most commonly found defects causing a left-to-right shunt...
August 2016: Pediatric Critical Care Medicine
Eric L Wald, Gal Finer, Mary E McBride, Nguyenvu Nguyen, John M Costello, Conrad L Epting
OBJECTIVES: Focusing on critically ill children with cardiac disease, we will review common causes of fluid perturbations, clinical recognition, and strategies to minimize and treat fluid-related complications. DATA SOURCE: MEDLINE and PubMed. CONCLUSIONS: Meticulous fluid management is vital in critically ill children with cardiac disease. Fluid therapy is important to maintain adequate blood volume and perfusion pressure in order to support cardiac output, tissue perfusion, and oxygen delivery...
August 2016: Pediatric Critical Care Medicine
Sarah P Psutka, Mark Heidenreich, Stephen A Boorjian, George C Bailey, John C Cheville, Suzanne B Stewart-Merrill, Christine M Lohse, Thomas D Atwell, Brian A Costello, Bradley C Leibovich, R Houston Thompson
OBJECTIVE: To describe clinicopathologic features associated with increased risk of renal fossa recurrences (RFR) following radical nephrectomy (RN) and to describe prognostic features associated with cancer-specific survival (CSS) among patients with RFR treated with primarily locally-directed therapy, systemically directed therapy, or expectant management. PATIENTS AND METHODS: Records of 2502 patients treated with RN for unilateral, sporadic, localized RCC between 1970 and 2006 were reviewed...
August 4, 2016: BJU International
Daniele Campa, Manuela Pastore, Manuel Gentiluomo, Renata Talar-Wojnarowska, Juozas Kupcinskas, Ewa Malecka-Panas, John P Neoptolemos, Willem Niesen, Pavel Vodicka, Gianfranco Delle Fave, H Bas Bueno-de-Mesquita, Maria Gazouli, Paola Pacetti, Milena Di Leo, Hidemi Ito, Harald Klüter, Pavel Soucek, Vincenzo Corbo, Kenji Yamao, Satoyo Hosono, Rudolf Kaaks, Yogesh Vashist, Domenica Gioffreda, Oliver Strobel, Yasuhiro Shimizu, Frederike Dijk, Angelo Andriulli, Audrius Ivanauskas, Peter Bugert, Francesca Tavano, Ludmila Vodickova, Carlo Federico Zambon, Martin Lovecek, Stefano Landi, Timothy J Key, Ugo Boggi, Raffaele Pezzilli, Krzysztof Jamroziak, Beatrice Mohelnikova-Duchonova, Andrea Mambrini, Franco Bambi, Olivier Busch, Valerio Pazienza, Roberto Valente, George E Theodoropoulos, Thilo Hackert, Gabriele Capurso, Giulia Martina Cavestro, Claudio Pasquali, Daniela Basso, Cosimo Sperti, Keitaro Matsuo, Markus Büchler, Kay-Tee Khaw, Jakob Izbicki, Eithne Costello, Verena Katzke, Christoph Michalski, Anna Stepien, Cosmeri Rizzato, Federico Canzian
The CDKN2A (p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing familiar pancreatic cancer and CDKN2A promoter hyper-methylation has been suggested to play a critical role both in pancreatic cancer onset and prognosis. In addition several unrelated SNPs in the 9p21.3 region, that includes the CDNK2A, CDNK2B and the CDNK2B-AS1 genes, are associated with the development of cancer in various organs...
July 29, 2016: Oncotarget
Sarah P Psutka, John C Cheville, Brian A Costello, Suzanne B Stewart-Merrill, Christine M Lohse, Bradley C Leibovich, Stephen A Boorjian, R Houston Thompson
OBJECTIVE: To evaluate the concordance of pathologic features in metastatic renal cell carcinoma (RCC) between the primary nephrectomy and metastasectomy specimens. METHODS: Primary nephrectomy (n = 454) and matched metastasectomy specimens (n = 680) from patients treated between 1970 and 2009 for RCC were re-reviewed by 1 urologic pathologist in a blinded fashion. RCC histologic subtype, grade, coagulative necrosis, and the presence of sarcomatoid differentiation were compared between the primary and the metastatic tumor with kappa statistics...
October 2016: Urology
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
July 2, 2016: International Journal of Palliative Nursing
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