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https://www.readbyqxmd.com/read/29717230/therapeutic-developments-in-pancreatic-cancer-current-and-future-perspectives
#1
REVIEW
John P Neoptolemos, Jörg Kleeff, Patrick Michl, Eithne Costello, William Greenhalf, Daniel H Palmer
The overall 5-year survival for pancreatic cancer has changed little over the past few decades, and pancreatic cancer is predicted to be the second leading cause of cancer-related mortality in the next decade in Western countries. The past few years, however, have seen improvements in first-line and second-line palliative therapies and considerable progress in increasing survival with adjuvant treatment. The use of biomarkers to help define treatment and the potential of neoadjuvant therapies also offer opportunities to improve outcomes...
May 1, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29703108/research-roundup
#2
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
April 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29702024/video-preoperative-ct-angiography-for-fibular-free-flap-reconstructions
#3
Bilal Mujtaba, Gaurav K Synghal, Patrick B Garvey, Behrang Amini, Tamara Miner Haygood, John E Madewell, Colleen M Costelloe
OBJECTIVE: The objective of this video article is to provide an introduction to the use of fibular free flaps. Normal and variant vascular anatomy of the fibular free flap is discussed, as are imaging acquisition and CT angiography interpretation, computer-assisted design and manufacturing, and the limitations of the fibular free flap. CONCLUSION: The fibular free flap is commonly used for head and neck reconstructive surgery. Variation exists between individuals regarding the origin of the peroneal artery and the perforating arteries...
April 27, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29608381/research-roundup
#4
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
March 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29572526/rapid-and-lasting-gains-from-solving-illegal-fishing
#5
Reniel B Cabral, Juan Mayorga, Michaela Clemence, John Lynham, Sonny Koeshendrajana, Umi Muawanah, Duto Nugroho, Zuzy Anna, Mira, Abdul Ghofar, Nimmi Zulbainarni, Steven D Gaines, Christopher Costello
Perhaps the greatest challenge facing global fisheries is that recovery often requires substantial short-term reductions in fishing effort, catches and profits. These costs can be onerous and are borne in the present; thus, many countries are unwilling to undertake such socially and politically unpopular actions. We argue that many nations can recover their fisheries while avoiding these short-term costs by sharply addressing illegal, unreported and unregulated (IUU) fishing. This can spur fishery recovery, often at little or no cost to local economies or food provision...
April 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29544418/brom-aortoplasty-for-supravalvular-aortic-stenosis
#6
Michael C Mongé, Osama M Eltayeb, John M Costello, Joyce T Johnson, Andrada R Popescu, Cynthia K Rigsby, Carl L Backer
BACKGROUND: Controversy remains regarding the optimal surgical approach for children with supravalvular aortic stenosis (SVAS). METHODS: Since 1997 we have used Brom three-patch aortoplasty for patients with SVAS. We prefer computed tomography (CT) imaging for preoperative evaluation rather than cardiac catheterization as it avoids the well-known morbidity of general anesthesia. The purpose of this study was to present our intermediate-term results of this strategy...
March 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29538381/taxonomy-based-on-science-is-necessary-for-global-conservation
#7
Scott A Thomson, Richard L Pyle, Shane T Ahyong, Miguel Alonso-Zarazaga, Joe Ammirati, Juan Francisco Araya, John S Ascher, Tracy Lynn Audisio, Valter M Azevedo-Santos, Nicolas Bailly, William J Baker, Michael Balke, Maxwell V L Barclay, Russell L Barrett, Ricardo C Benine, James R M Bickerstaff, Patrice Bouchard, Roger Bour, Thierry Bourgoin, Christopher B Boyko, Abraham S H Breure, Denis J Brothers, James W Byng, David Campbell, Luis M P Ceríaco, István Cernák, Pierfilippo Cerretti, Chih-Han Chang, Soowon Cho, Joshua M Copus, Mark J Costello, Andras Cseh, Csaba Csuzdi, Alastair Culham, Guillermo D'Elía, Cédric d'Udekem d'Acoz, Mikhail E Daneliya, René Dekker, Edward C Dickinson, Timothy A Dickinson, Peter Paul van Dijk, Klaas-Douwe B Dijkstra, Bálint Dima, Dmitry A Dmitriev, Leni Duistermaat, John P Dumbacher, Wolf L Eiserhardt, Torbjørn Ekrem, Neal L Evenhuis, Arnaud Faille, José L Fernández-Triana, Emile Fiesler, Mark Fishbein, Barry G Fordham, André V L Freitas, Natália R Friol, Uwe Fritz, Tobias Frøslev, Vicki A Funk, Stephen D Gaimari, Guilherme S T Garbino, André R S Garraffoni, József Geml, Anthony C Gill, Alan Gray, Felipe G Grazziotin, Penelope Greenslade, Eliécer E Gutiérrez, Mark S Harvey, Cornelis J Hazevoet, Kai He, Xiaolan He, Stephan Helfer, Kristofer M Helgen, Anneke H van Heteren, Francisco Hita Garcia, Norbert Holstein, Margit K Horváth, Peter H Hovenkamp, Wei Song Hwang, Jaakko Hyvönen, Melissa B Islam, John B Iverson, Michael A Ivie, Zeehan Jaafar, Morgan D Jackson, J Pablo Jayat, Norman F Johnson, Hinrich Kaiser, Bente B Klitgård, Dániel G Knapp, Jun-Ichi Kojima, Urmas Kõljalg, Jenő Kontschán, Frank-Thorsten Krell, Irmgard Krisai-Greilhuber, Sven Kullander, Leonardo Latella, John E Lattke, Valeria Lencioni, Gwilym P Lewis, Marcos G Lhano, Nathan K Lujan, Jolanda A Luksenburg, Jean Mariaux, Jader Marinho-Filho, Christopher J Marshall, Jason F Mate, Molly M McDonough, Ellinor Michel, Vitor F O Miranda, Mircea-Dan Mitroiu, Jesús Molinari, Scott Monks, Abigail J Moore, Ricardo Moratelli, Dávid Murányi, Takafumi Nakano, Svetlana Nikolaeva, John Noyes, Michael Ohl, Nora H Oleas, Thomas Orrell, Barna Páll-Gergely, Thomas Pape, Viktor Papp, Lynne R Parenti, David Patterson, Igor Ya Pavlinov, Ronald H Pine, Péter Poczai, Jefferson Prado, Divakaran Prathapan, Richard K Rabeler, John E Randall, Frank E Rheindt, Anders G J Rhodin, Sara M Rodríguez, D Christopher Rogers, Fabio de O Roque, Kevin C Rowe, Luis A Ruedas, Jorge Salazar-Bravo, Rodrigo B Salvador, George Sangster, Carlos E Sarmiento, Dmitry S Schigel, Stefan Schmidt, Frederick W Schueler, Hendrik Segers, Neil Snow, Pedro G B Souza-Dias, Riaan Stals, Soili Stenroos, R Douglas Stone, Charles F Sturm, Pavel Štys, Pablo Teta, Daniel C Thomas, Robert M Timm, Brian J Tindall, Jonathan A Todd, Dagmar Triebel, Antonio G Valdecasas, Alfredo Vizzini, Maria S Vorontsova, Jurriaan M de Vos, Philipp Wagner, Les Watling, Alan Weakley, Francisco Welter-Schultes, Daniel Whitmore, Nicholas Wilding, Kipling Will, Jason Williams, Karen Wilson, Judith E Winston, Wolfgang Wüster, Douglas Yanega, David K Yeates, Hussam Zaher, Guanyang Zhang, Zhi-Qiang Zhang, Hong-Zhang Zhou
No abstract text is available yet for this article.
March 2018: PLoS Biology
https://www.readbyqxmd.com/read/29533351/useful-references-in-pediatric-cardiac-intensive-care-the-2017-update
#8
Karen C Uzark, John M Costello, Holly C DeSena, Ravi Thiagajaran, Melissa Smith-Parrish, Katja M Gist
OBJECTIVES: Pediatric cardiac intensive care continues to evolve, with rapid advances in knowledge and improvement in clinical outcomes. In the past, the Board of Directors of the Pediatric Cardiac Intensive Care Society created and subsequently updated a list of sentinel references focused on the care of critically ill children with congenital and acquired heart disease. The objective of this article is to provide clinicians with a compilation and brief summary of updated and useful references that have been published since 2012...
March 10, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29469644/research-roundup
#9
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
February 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29432615/glioma-through-the-looking-glass-molecular-evolution-of-diffuse-gliomas-and-the-glioma-longitudinal-analysis-consortium
#10
Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, Hoon Kim, Mathilde C M Kouwenhoven, Kerrie L McDonald, Hrvoje Miletic, Do-Hyun Nam, Ho Keung Ng, Simone P Niclou, Houtan Noushmehr, Ryan Ormond, Laila M Poisson, Guido Reifenberger, Federico Roncaroli, Jason K Sa, Peter A E Sillevis Smitt, Marion Smits, Camila F Souza, Ghazaleh Tabatabai, Erwin G Van Meir, Roel G W Verhaak, Colin Watts, Pieter Wesseling, Adelheid Woehrer, W K Alfred Yung, Christine Jungk, Ann-Christin Hau, Eric van Dyck, Bart A Westerman, Julia Yin, Olajide Abiola, Nikolaj Zeps, Sean Grimmond, Michael Buckland, Mustafa Khasraw, Erik P Sulman, Andrea M Muscat, Lucy Stead
Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas (TCGA) and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal AnalySiS Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas...
February 8, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29409553/diagnostic-errors-in-paediatric-cardiac-intensive-care
#11
Priya N Bhat, John M Costello, Ranjit Aiyagari, Paul J Sharek, Claudia A Algaze, Mjaye L Mazwi, Stephen J Roth, Andrew Y Shin
IntroductionDiagnostic errors cause significant patient harm and increase costs. Data characterising such errors in the paediatric cardiac intensive care population are limited. We sought to understand the perceived frequency and types of diagnostic errors in the paediatric cardiac ICU. METHODS: Paediatric cardiac ICU practitioners including attending and trainee physicians, nurse practitioners, physician assistants, and registered nurses at three North American tertiary cardiac centres were surveyed between October 2014 and January 2015...
May 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29402724/effects-of-acute-or-chronic-heat-exposure-exercise-and-dehydration-on-plasma-cortisol-il-6-and-crp-levels-in-trained-males
#12
Joseph T Costello, Rebecca A Rendell, Matthew Furber, Heather C Massey, Michael J Tipton, John S Young, Jo Corbett
This study examined the acute and chronic effects of euhydrated and hypohydrated heat exposure, on biomarkers of stress and inflammation. Eight trained males [mean (SD) age: 21 (3) y; mass: 77.30 (4.88) kg; V̇O2max : 56.9 (7.2) mL kg-1  min-1 ] undertook two heat acclimation programmes (balanced cross-over design), once drinking to maintain euhydration and once with restricted fluid-intake (permissive dehydration). Days 1, 6, and 11 were 60 min euhydrated exercise-heat stress tests (40 °C; 50% RH, 35% peak power output), days 2-5 and 7-10 were 90 min, isothermal-strain (target rectal temperature: 38...
February 2, 2018: Cytokine
https://www.readbyqxmd.com/read/29397933/associations-between-unplanned-cardiac-reinterventions-and-outcomes-after-pediatric-cardiac-operations
#13
John M Costello, Michael C Mongé, Kevin D Hill, Sunghee Kim, Sara K Pasquali, Babatunde A Yerokun, Jeffrey P Jacobs, Carl L Backer, Mjaye L Mazwi, Marshall L Jacobs
BACKGROUND: After pediatric heart operations, we sought to determine the incidence of unplanned cardiac reinterventions during the same hospitalization, assess risk factors for these reinterventions, and explore associations between reinterventions and outcomes. We hypothesized that younger patients undergoing more complex operations would be at greater risk for unplanned cardiac reinterventions and that operative mortality and postoperative length of stay (PLOS) would be greater in patients who undergo reintervention than in those who do not...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29395633/the-reproducibility-of-10-and-20km-time-trial-cycling-performance-in-recreational-cyclists-runners-and-team-sport-athletes
#14
David N Borg, John O Osborne, Ian B Stewart, Joseph T Costello, Jesse N L Sims, Geoffrey M Minett
OBJECTIVES: This study aimed to determine the reliability of 10 and 20km cycling time trial (TT) performance on the Velotron Pro in recreational cyclists, runners and intermittent-sprint based team sport athletes, with and without a familiarisation. DESIGN: Thirty-one male, recreationally active athletes completed four 10 or 20km cycling TTs on different days. METHODS: During cycling, power output, speed and cadence were recorded at 23Hz, and heart rate and rating of perceived exertion (RPE) were recorded every km...
January 26, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29368555/research-roundup
#15
John Costello
Synopses of a selection of recently published research articles of relevance to palliative care.
January 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29350556/rehabilitation-of-a-young-athlete-with-extension-based-low-back-pain-addressing-motor-control-impairments-and-central-sensitization
#16
John J Winslow, Mark Jackson, Andrew Getzin, Michael Costello
OBJECTIVE:   To describe the conservative management of a young athlete with extension-based (EB) low back pain (LBP). BACKGROUND:   We present the case of a 15-year-old female high school gymnast with a 4-year history of EB LBP. Magnetic resonance imaging revealed a healed spondylolysis and significant atrophy with fatty infiltrate of the lumbar multifidi muscles (LMM). She had several courses of outpatient orthopaedic rehabilitation that focused on core muscle strengthening (improving activation and strength of the LMM and transversus abdominus muscle in a neutral pelvic position) without long-lasting improvement...
February 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29228862/oculomotor-cognitive-control-abnormalities-in-australian-rules-football-players-with-a-history-of-concussion
#17
Meaghan Clough, Steven Mutimer, David K Wright, Adrian Tsang, Daniel M Costello, Andrew J Gardner, Peter Stanwell, Richelle Mychasiuk, Mujun Sun, Rhys D Brady, Stuart J McDonald, Kyria M Webster, Maddison R Johnstone, Bridgette D Semple, Denes V Agoston, Owen B White, Richard Frayne, Joanne Fielding, Terence J O'Brien, Sandy R Shultz
This study used oculomotor, cognitive, and multi-modal magnetic resonance imaging (MRI) measures to assess for neurological abnormalities in current asymptomatic amateur Australian rules footballers (i.e., Australia's most participated collision sport) with a history of sports-related concussion (SRC). Participants were 15 male amateur Australian rules football players with a history of SRC greater than 6 months previously, and 15 sex-, age-, and education-matched athlete control subjects that had no history of neurotrauma or participation in collision sports...
March 1, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29205054/best-practices-protocol-for-the-evaluation-of-bulbar-dysfunction-summary-recommendations-from-the-neals-bulbar-subcommittee-symposium
#18
Gary L Pattee, Emily K Plowman, Benjamin R Brooks, James D Berry, Nazem Atassi, Jennifer L Chapin, Kendrea Garand, Yana Yunusova, Courtney E Mcilduff, Eufrosina Young, John M Costello, Eric A Macklin, Eduardo R Locatelli, Vincenzo Silani, Daragh Heitzman, James Wymer, Stephen A Goutman, Deborah F Gelinas, Richard Smith, Bridget Perry, Paige Nalipinski, Kaila Stipancic, Meghan O'Brien, Stacey L Sullivan, Jordan Green
OBJECTIVE: The aim of this Symposium was to develop a consensus based, bulbar assessment protocol for implementation within NEALS clinics. METHODS: A one-day symposium, held in April 2017, was organized into Speech and Swallowing sections to establish summary recommendations for the assessment of bulbar dysfunction within each group. RESULTS: Summary recommendations included speech referrals and AAC evaluations at initial visit, CNS-BFS, maximum sustained phonation, and speaking rate...
May 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29187110/experience-with-an-acuity-adaptable-care-model-for-pediatric-cardiac-surgery
#19
John M Costello, Elizabeth Preze, Nguyenvu Nguyen, Mary E McBride, James W Collins, Osama M Eltayeb, Michael C Mongé, Barbara J Deal, Michelle M Stephenson, Carl L Backer
BACKGROUND: We describe the implementation of and outcomes associated with an acuity adaptable care model for pediatric patients undergoing cardiac surgery. METHODS: Consecutive patients undergoing an index cardiac operation between July 2007 and June 2015 were included. From July 2007 through June 2010, a conventional model existed in which patients moved among units and care teams based on age, severity of illness, and operative status (conventional group). A transitional period existed between July 2010 and June 8, 2012 (transitional group)...
November 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29180601/widespread-utilization-of-passive-energy-recapture-in-swimming-medusae
#20
Brad J Gemmell, Sean P Colin, John H Costello
Recently, it has been shown that some medusae are capable of swimming very efficiently, i.e. with a low cost of transport, and that this is in part due to passive energy recapture (PER) which occurs during bell relaxation. We compared the swimming kinematics among a diverse array of medusae, varying in taxonomy, morphology and propulsive and foraging modes, in order to evaluate the prevalence of PER in medusae. We found that while PER was common among taxa, the magnitude of the contribution to overall swimming varied greatly...
January 11, 2018: Journal of Experimental Biology
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