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https://www.readbyqxmd.com/read/28914478/mechanistic-insights-into-cyclic-peptide-generation-by-dnae-split-inteins-through-quantitative-and-structural-investigation
#1
Leonhard Kick, Sabrina Harteis, Maximilian F Koch, Sabine Schneider
Inteins carry out protein-splicing reactions, which are utilised in protein chemistry, protein engineering and biotechnological applications. Rearrangement of the order of the domains in split-inteins results in a head-to-tail cyclisation of the target sequence, which can be used to genetically encode and express libraries of cyclic peptides. The efficiency of the splicing reaction depends on the target sequence. Here we used mass spectrometry to assess the cyclic peptide formation of different, hexameric target sequences in vivo by the DnaE split-inteins from Synechocystis sp...
September 15, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28912743/act-on-numbers-numerical-magnitude-influences-selection-and-kinematics-of-finger-movement
#2
Rosa Rugani, Sonia Betti, Francesco Ceccarini, Luisa Sartori
In the past decade hand kinematics has been reliably adopted for investigating cognitive processes and disentangling debated topics. One of the most controversial issues in numerical cognition literature regards the origin - cultural vs. genetically driven - of the mental number line (MNL), oriented from left (small numbers) to right (large numbers). To date, the majority of studies have investigated this effect by means of response times, whereas studies considering more culturally unbiased measures such as kinematic parameters are rare...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28910200/comparison-of-two-%C3%AE-alanine-dosing-protocols-on-muscle-carnosine-elevations
#3
David D Church, Jay R Hoffman, Alyssa N Varanoske, Ran Wang, Kayla M Baker, Michael B La Monica, Kyle S Beyer, Sarah J Dodd, Leonardo P Oliveira, Roger C Harris, David H Fukuda, Jeffrey R Stout
OBJECTIVE: β-alanine (BA) is a nonproteogenic amino acid that combines with histidine to form carnosine. The amount taken orally in individual doses, however, is limited due to symptoms of paresthesia that are associated with higher doses. The use of a sustained-release formulation has been reported to reduce the symptoms of paresthesia, suggesting that a greater daily dose may be possible. The purpose of the present study was to determine whether increasing the daily dose of BA can result in a similar increase in muscle carnosine in a reduced time...
September 14, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28903824/pharmacokinetic-profiles-of-nalbuphine-after-intraperitoneal-and-subcutaneous-administration-to-c57bl-6-mice
#4
Brenda L Kick, Pan Shu, Bo Wen, Duxin Sun, Douglas K Taylor
Mice undergo a variety of procedures that necessitate the use of analgesic agents. Opioids are often essential to successful pain management plans, but most are controlled substances, and their use requires appropriate federal and state registrations. Nalbuphine is a potentially effective opioid analgesic for mice that is not currently classified as a controlled substance. This compound has received little attention as an analgesic for mice, and standard dosage regimens have not been developed. Here we compared the pharmacokinetic profiles of 10 mg/kg nalbuphine in male C57BL/6 mice subcutaneous or intraperitoneal administration...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28900560/building-a-better-gluteal-bridge-electromyographic-analysis-of-hip-muscle-activity-during-modified-single-leg-bridges
#5
B J Lehecka, Michael Edwards, Ryan Haverkamp, Lani Martin, Kambry Porter, Kailey Thach, Richard J Sack, Nils A Hakansson
BACKGROUND: Gluteal strength plays a role in injury prevention, normal gait patterns, eliminating pain, and enhancing athletic performance. Research shows high gluteal muscle activity during a single-leg bridge compared to other gluteal strengthening exercises; however, prior studies have primarily measured muscle activity with the active lower extremity starting in 90 ° of knee flexion with an extended contralateral knee. This standard position has caused reports of hamstring cramping, which may impede optimal gluteal strengthening...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28894444/modeling-kick-kill-strategies-toward-hiv-cure
#6
REVIEW
Esteban A Hernandez-Vargas
Although combinatorial antiretroviral therapy (cART) potently suppresses the virus, a sterile or functional cure still remains one of the greatest therapeutic challenges worldwide. Reservoirs are infected cells that can maintain HIV persistence for several years in patients with optimal cART, which is a leading obstacle to eradicate the virus. Despite the significant progress that has been made in our understanding of the diversity of cells that promote HIV persistence, many aspects that are critical to the development of effective therapeutic approaches able to purge the latent CD4+ T cell reservoir are poorly understood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28894130/a-chinese-pane-like-2d-metal-organic-framework-showing-magnetic-relaxation-and-luminescence-dual-functions
#7
Cai-Ming Liu, De-Qing Zhang, Xiang Hao, Dao-Ben Zhu
The discovery of graphene kicked off the curtain of atom-type two-dimensional (2D) materials. Layered metal-organic frameworks (MOFs) as parallel molecule-based 2D materials are more designable and more diverse, and magnetism may be induced by their metal ion nodes. However, the multifunctional 2D plane-like MOFs are very difficult to obtain. Here we describe a Chinese pane-like 2D MOF constructed from the Ln(3+) cation and the nanoscale luminescent tritopic ligand tris(4'-carboxybiphenyl)-amine, responding to the slow magnetic relaxation and luminescence properties, respectively...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893455/-enjoying-the-kick-locating-pleasure-within-the-drug-consumption-room
#8
Tristan Duncan, Cameron Duff, Bernadette Sebar, Jessica Lee
BACKGROUND: Harm reduction policy and praxis has long struggled to accommodate the pleasures of alcohol and other drug use. Whilst scholars have consistently highlighted this struggle, how pleasure might come to practically inform the design and delivery of harm reduction policies and programs remains less clear. The present paper seeks to move beyond conceptual critiques of harm reduction's 'pleasure oversight' to more focused empirical analysis of how flows of pleasure emerge, circulate and, importantly, may be reoriented in the course of harm reduction practice...
September 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28893280/eradication-of-hiv-1-latent-reservoirs-through-therapeutic-vaccination
#9
REVIEW
Joshua Pankrac, Katja Klein, Jamie F S Mann
Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such as cancer, imaging, and genetic engineering have fueled rapid advancements in HIV cure research. In the last few years, several studies have focused on the development of "Kick and Kill" therapies to reverse HIV latency and kick start viral translational activity...
September 12, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28892460/fatigue-related-changes-in-technique-emerge-at-different-timescales-during-repetitive-training
#10
Daniel Aragonés, Alexander Eekhoff, Fabian Horst, Wolfgang Immanuel Schöllhorn
Training consisting of numerous repetitions performed as closely as possible to ideal techniques is common in sports and every-day tasks. Little is known about fatigue-related technique changes that emerge at different timescales when repeating complex actions such as a karate front kick. Accordingly, 15 karatekas performed 600 kicks (1 pre-block and 9 blocks). The pre-block comprised 6 kicks (3 with each leg) at maximum intensity (K-100%). Each block comprised 60 kicks (10 with each leg) at 80% of their self-perceived maximum intensity (K-80%) plus 6 K-100%...
September 11, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28889073/infant-intralimb-coordination-and-torque-production-influence-of-prematurity
#11
Barbara Sargent, Hendrik Reimann, Masayoshi Kubo, Linda Fetters
The purpose of this study is to investigate changes in leg joint coordination, intersegmental dynamics, and their relation in infants born preterm (PT) during the first months of life. Kicking actions were analyzed of 11 infants born PT at 6 and 15-weeks corrected age (CA) using three-dimensional kinematics and kinetics; results were compared to the kicking actions of 10 infants born full-term (FT). Both groups changed from a predominately in-phase coordination at 6-weeks CA to a less in-phase coordination at 15-weeks CA, however, at 6-weeks CA, infants born PT demonstrated less in-phase coordination of their ankle joints with their hip and knee joints...
September 7, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28889042/marginal-en-bloc-resection-of-c2-3-chordoma-with-bilateral-vertebral-artery-preservation-and-mesh-cage-reconstruction-with-review-of-previously-published-cases
#12
Steven O Tenny, Landon D Ehlers, J Will Robbins, Christopher C Gillis
BACKGROUND: Chordomas arise from remnants of the notocord and occur throughout the neuroaxis. En bloc resection of chordomas can prove especially challenging in the upper cervical spine secondary to the unique structural anatomy and intimate relationship to the vertebral arteries and spinal cord. CASE DESCRIPTION: We describe the resection of a C2-3 chordoma in a 55 year old female in two stage fashion with preservation of the vertebral arteries. First a posterior instrumented fusion and removal of the posterior elements was performed, followed by an anterior transmandibular en bloc resection with cage reconstruction with kick-plate support achievable with off-the-shelf products...
September 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28888326/artists-create-puzzles-scientists-solve-them
#13
Joseph L Goldstein
The Spanish artist Diego Velázquez created a puzzle-painting 360 years ago that to this day remains unsolved, but still mystifies and intrigues. Unlike artists who get their thrills by creating puzzles that stimulate the imagination, scientists get their kicks by solving puzzles that advance biomedical research.
August 23, 2017: Cell
https://www.readbyqxmd.com/read/28885092/infant-discovery-learning-and-lower-extremity-coordination-influence-of-prematurity
#14
Barbara Sargent, Masayoshi Kubo, Linda Fetters
AIMS: Preterm infants at increased risk for neurodevelopmental disabilities, including cerebral palsy, demonstrate reduced selective leg joint coordination. Full-term infants demonstrate more selective hip-knee coordination when specific leg actions are reinforced using an overhead infant mobile. The purpose of this pilot study was to determine the ability of preterm infants to: (1) perform and learn through discovery, the contingency between leg action and mobile activation, and (2) demonstrate more selective hip-knee coordination when leg actions are reinforced with mobile activation...
September 8, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28878534/endoscopic-management-of-posterior-ankle-impingement-syndrome-a-case-report
#15
Jayant Kumar, Maninder S Singh, Suparna Tandon
Posterior ankle impingement syndrome (PAIS) is a clinical condition characterized by pain in the posterior aspect of ankle on performing activities requiring extreme plantar flexion. The impinging lesion could be bony and/or soft tissue. The operative treatment aims at removing the impinging lesion either by open or endoscopic surgery. The later has been shown to have benefits of early return to sports, better cosmesis, less wound complications. We report a case of a 19 year old footballer with PAIS secondary to Os Trigonum...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28872372/the-specificity-of-rugby-union-training-sessions-in-preparation-for-match-demands
#16
Patrick G Campbell, Jonathan M Peake, Geoffrey M Minett
PURPOSE: Investigations into the specificity of rugby union training practices in preparation for competitive demands has predominantly focussed on physical and physiological demands. The evaluation of the contextual variance in perceptual strain or skill requirements between training and matches in rugby union is unclear, yet holistic understanding may assist to optimise training design. This study evaluated the specificity of physical, physiological, perceptual and skill demands of training sessions compared with competitive match-play in pre-professional, elite club rugby union...
September 5, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28869580/association-between-functional-movements-skills-and-health-indicators-in-children-aged-between-9-and-12-years-old
#17
Megan E Comeau, Danielle R Bouchard, Cindy Levesque, Michel J Jonhson, Brittany V Rioux, Andrea Mayo, Martin Sénéchal
Background: Children's health is a current concern and data suggests that poor fundamental movement skills (FMS) could be associated with poor health, which may or may not be mediated by low physical activity level. However, tools to assess FMS have not been standardized, and could consequently lead to different associations between FMS and health indicators. Objective: The primary objective of this study was to evaluate the associations between FMS and health indicators using two different FMS measurement tools often used in Canada...
September 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28867139/bite-wounds-caused-by-a-wild-boar-a-case-report
#18
Hiroki Nagasawa, Kazuhiko Omori, Hiroyuki Maeda, Ikuto Takeuchi, Suguru Kato, Takashi Iso, Kei Jitsuiki, Toshihiko Yoshizawa, Kouhei Ishikawa, Hiromichi Ohsaka, Youichi Yanagawa
A 74-year-old man was attacked by a wild boar while on his way home from his farm in the daytime in winter 2017 on the rural Izu peninsula. He did not provoke the boar; however, hunters were hunting animals in the mountains near the farm around the same time. The boar bit his left leg, and the man fell to the ground. The boar continued biting the man's left leg, and the man delivered a few kicks to the boar's face with his right leg. The boar then bit his right foot and ran away. The man was taken to a hospital, and a physical examination revealed 3 bite wounds on his left leg and right foot...
August 31, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28861054/screening-of-tb-actives-for-activity-against-nontuberculous-mycobacteria-delivers-high-hit-rates
#19
Jian Liang Low, Mu-Lu Wu, Dinah Binte Aziz, Benoît Laleu, Thomas Dick
The prevalence of lung disease due to infections with nontuberculous mycobacteria (NTM) has been increasing and surpassed tuberculosis (TB) in some countries. Treatment outcomes are often unsatisfactory, highlighting an urgent need for new anti-NTM medications. Although NTM in general do not respond well to TB specific drugs, the similarities between NTM and Mycobacterium tuberculosis at the molecular and cell structural level suggest that compound libraries active against TB could be leveraged for NTM drug discovery...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28858059/the-relationship-between-repeated-kicking-performance-and-maximal-aerobic-capacity-in-elite-junior-australian-football
#20
Jacob Joseph, Carl Woods, Christopher Joyce
Australian football (AF) is a physically demanding game, requiring players to engage in a range of anaerobic activities interspersed with prolonged aerobic exercise. Coupled, players have to perform a range of technical skills, the most fundamental of which being to effectively kick (dispose) the ball. The aim of this study was to ascertain the extent to which aerobic capacity influenced kicking performance in AF. Twenty four elite U18 players competing in the same U18 competition performed the Australian Football Kicking test (AFK) three times with the yo-yo IR2 completed twice (between each AFK), with no rest between all three AFKs...
August 26, 2017: Journal of Strength and Conditioning Research
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