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https://www.readbyqxmd.com/read/29793127/effects-of-sodium-salicylate-on-the-determination-of-lead-210-bismuth-210-by-cerenkov-counting
#1
Yadong Wang, Yonggang Yang, Lijuan Song, Yan Ma, Maoyi Luo, Xiongxin Dai
Due to the nature of Cerenkov radiation and instrumental limitations, detection efficiencies of 210 Bi by Cerenkov counting are generally quite low (~15%). Sodium salicylate, acting as a wavelength shifter, has been used to improve the detection efficiency of Cerenkov photons. In this study, we found that the addition of sodium salicylate could significantly increase the counting efficiencies of 210 Pb/210 Bi in aqueous samples. Meanwhile, a sharp increase of the counting efficiency for the alphas from 210 Po was also observed with the addition of high concentration of sodium salicylate, implying that scintillation light rather than Cerenkov photons from the alphas has been produced...
May 21, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29792884/pharmacological-inhibition-of-dna-methylation-attenuates-pressure-overload-induced-cardiac-hypertrophy-in-rats
#2
Justus Stenzig, Yvonne Schneeberger, Alexandra Löser, Barbara S Peters, Andreas Schaefer, Rong-Rong Zhao, Shi Ling Ng, Grit Höppner, Birgit Geertz, Marc N Hirt, Wilson Tan, Eleanor Wong, Hermann Reichenspurner, Roger S-Y Foo, Thomas Eschenhagen
BACKGROUND: Heart failure is associated with altered gene expression and DNA methylation. De novo DNA methylation is associated with gene silencing, but its role in cardiac pathology remains incompletely understood. We hypothesized that inhibition of DNA methyltransferases (DNMT) might prevent the deregulation of gene expression and the deterioration of cardiac function under pressure overload (PO). To test this hypothesis, we evaluated a DNMT inhibitor in PO in rats and analysed DNA methylation in cardiomyocytes...
May 21, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29791656/long-term-maintenance-of-glucose-and-lipid-concentrations-after-roux-en-y-gastric-bypass
#3
Fernanda Cristina Carvalho Mattos Magno, Priscila Alves Medeiros de Sousa, Marcelo Paiva Rodrigues, Lícia Lopes Pio Pereira, José Egídio Paulo de Oliveira, Eliane Lopes Rosado, João Régis Ivar Carneiro
OBJECTIVE: Roux-en-Y gastric bypass (RYGB) reduces body weight and the comorbidities associated with obesity. The aim of this study was to evaluate whether glucose and lipid profiles were maintained during a 5-year follow-up period after RYGB. SUBJECTS AND METHODS: Anthropometric and laboratory data from 323 patients who had undergone this operation were analyzed. Differences in laboratory variables between the baseline and 12, 24, 36, 48 and 60 months postoperatively (PO) were assessed using a one-way ANOVA test to compare the three groups...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29790233/factors-regulating-carbon-sinks-in-mangrove-ecosystems
#4
Shi-Bo Li, Po-Hung Chen, Jih-Sheng Huang, Mei-Li Hsueh, Li-Yung Hsieh, Chen-Lu Lee, Hsing-Juh Lin
Mangroves are recognized as one of the richest carbon storage systems. However, the factors regulating carbon sinks in mangrove ecosystems are still unclear, particularly in the subtropical mangroves. The biomass, production, litterfall, detrital export and decomposition of the dominant mangrove vegetation in subtropical (Kandelia obovata) and tropical (Avicennia marina) Taiwan were quantified from October 2011 to July 2014 to construct the carbon budgets. Despite the different tree species, a principal component analysis revealed the site or environmental conditions had a greater influence than the tree species on the carbon processes...
May 23, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29789841/f-doping-effects-on-carbon-coated-li-3-v-2-po-4-3-as-a-cathode-for-high-performance-lithium-rechargeable-batteries-combined-experimental-and-dft-studies
#5
Jinggao Wu, Maowen Xu, Chun Tang, Guannan Li, Hong He, Chang Ming Li
F-Doping effects on polyaniline-derived carbon coated Li3V2(PO4)3 (Li3V2(PO4)3-xFx@C) as a cathode for high performance Li rechargeable batteries are systematically investigated with a combined experimental and DFT theoretical calculation approach. The results clearly indicate that the doping amount has a significant impact on the rate capability and long cycle life. The optimal material (Li3V2(PO4)2.88F0.12@C) delivers 123.16 mA h g-1@2C, which is close to the theoretical value (133 mA h g-1), while showing a greatly improved cycle stability...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29789225/grafting-for-bone-defects-after-curettage-of-benign-bone-tumor-analysis-of-factors-influencing-the-bone-healing
#6
Po-Kuei Wu, Cheng-Fong Chen, Chao-Ming Chen, Shang-Wen Tsai, Yu-Chi Cheng, Ming-Chau Chang, Wei-Ming Chen
BACKGROUND: Simple bone cyst often weaken bone properties and predispose to pathological fractures, requiring tumor excision and the filling of bone defects with grafts to prevent complications. The purpose of this study was to evaluate factors potentially affecting the quality and efficiency of graft healing. METHODS: This study retrospectively assessed 84 patients with simple bone cysts who had undergone tumor excision and filling of the bone defects with grafts between 2004 and 2014...
May 19, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29788114/magnolol-inhibits-human-glioblastoma-cell-migration-by-regulating-n-cadherin
#7
Yu-Chen Cheng, Min-Jen Tsao, Chen-Yang Chiu, Po-Chieh Kan, Ying Chen
Glioblastoma is a primary malignant brain tumor with a poor prognosis. An effective treatment for glioblastoma is needed. Magnolol is a natural compound from Magnolia officinalis suggested to have antiproliferative activity. The aim of this research was to investigate the anticancer effects of magnolol in glioma, with an emphasis on migration and the underlying mechanism. Magnolol decreased the expression of focal adhesion-related proteins and inhibited LN229 and U87MG glioma cell migration. The levels of phosphorylated myosin light chain (p-MLC), phosphorylated myosin light chain kinase and myosin phosphatase target subunit 1 were reduced in response to magnolol treatment...
June 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29787994/bioavailability-of-wilforlide-a-in-mice-and-its-concentration-determination-using-an-hplc-apci-ms-ms-method
#8
Zhijun Wang, Steven Yeung, Shang Chen, Yasmin Moatazedi, Moses S S Chow
Wilforlide A (WA), an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases, is a quality control marker for TW product. At present, the bioavailability/pharmacokinetics of WA is not known. Such information is not only essential to evaluate the relevance of WA as a quality control maker, but also important for future clinical efficacy studies. Therefore, a high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometric method (HPLC-APCI-MS/MS) was developed and applied to a bioavailability/pharmacokinetic study of WA...
May 16, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29786630/effect-of-cadence-on-time-trial-performance-in-recreational-female-cyclists
#9
Patricia L Graham, Robert F Zoeller, Patrick L Jacobs, Michael A Whitehurst
Graham, PL, Zoeller, RF, Jacobs, PL, and Whitehurst, MA. Effect of cadence on time trial performance in recreational female cyclists. J Strength Cond Res 32(6): 1739-1744, 2018-The impact of pedaling cadence on cycling performance remains unresolved especially in female cyclists. The purpose of this study was to determine the effect of cadence on time trial (TT) performance in recreational female cyclists. Ten recreational female cyclists volunteered to participate in this study. Subjects performed 3 exercise sessions: 1 to assess peak oxygen uptake (V[Combining Dot Above]O2peak) and 2 TTs...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29785836/facing-death-alone-or-together-investigating-the-interdependence-of-death-anxiety-dysfunctional-attitudes-and-quality-of-life-in-patient-caregiver-dyads-confronting-lung-cancer
#10
Bobo Hi-Po Lau, Daniel F K Wong, Y L Fung, Jillian Zhou, Cecilia L W Chan, Amy Y M Chow
BACKGROUND: Based on the cognitive theory, anxiety arising from the awareness of death and dying may activate dysfunctional attitudes, which may then reduce quality of life. This study examined the interdependence and the mediating role of dysfunctional attitudes on the relationship between death anxiety and quality of life among patients with lung cancer and their caregivers. METHODS: From March 2016 to April 2017, 173 pairs of patients and their caregivers enrolled in a randomized controlled trial of psychosocial support...
May 21, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29785011/a-genome-wide-cross-trait-analysis-from-uk-biobank-highlights-the-shared-genetic-architecture-of-asthma-and-allergic-diseases
#11
Zhaozhong Zhu, Phil H Lee, Mark D Chaffin, Wonil Chung, Po-Ru Loh, Quan Lu, David C Christiani, Liming Liang
Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available independent genome-wide association studies were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (rg  = 0.75, P = 6.84 × 10-62 ). Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci...
May 21, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29783900/the-efficacy-comparison-of-citalopram-fluoxetine-and-placebo-on-motor-recovery-after-ischemic-stroke-a-double-blind-placebo-controlled-randomized-controlled-trial
#12
Marjan Asadollahi, Mahtab Ramezani, Ziba Khanmoradi, Ehsan Karimialavijeh
OBJECTIVE: The present study aimed to assess the effectiveness of oral citalopram, compared with fluoxetine and a placebo, in patients with post-stroke motor disabilities. DESIGN: A randomized double-blind placebo-controlled clinical trial was conducted between January 2015 and January 2016. SETTING: The neurology department of a university-affiliated urban hospital in Tehran, Iran. SUBJECTS: Ninety adult patients with acute ischemic stroke, hemiplegia, or hemiparesis and a Fugl-Meyer Motor Scale score of below 55 were included...
May 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29782917/detoxification-and-immunoprotection-of-zn-ii-curcumin-in-juvenile-pacific-white-shrimp-litopenaeus-vannamei-feed-with-aflatoxin-b1
#13
Ying-Ying Yu, Jin Niu, Pen Yin, Yong-Jian Liu, Li-Xia Tian, Donghui Xu
Aflatoxins, which was produced by Aspergillus flavus or Aspergillus parasiticus fungi during grain and feed processing or storage, could cause severe health problems and reduction of yield during shrimp cultures. To evaluate toxic effects of aflatoxin B1 (AFB1) in juvenile Pacific white shrimp (Litopenaeus vannamei) and potential protective effect of Zn(II)-curcumin (Zn-CM), four experimental diets (control, 500 μg/kg AFB1, 500 μg/kg AFB1+100 mg/kg Zn-CM, 500 μg/kg AFB1+200 mg/kg Zn-CM) were formulated in quadruplicate to feed the shrimp for 8 weeks...
May 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29782859/a-paeonol-derivative-yph-pa3-promotes-the-differentiation-of-monocyte-macrophage-lineage-precursor-cells-into-osteoblasts-and-enhances-their-autophagy
#14
Chun-Hao Tsai, Ming-Hua Hsu, Po-Hao Huang, Chin-Tung Hsieh, Ying-Ming Chiu, Dong-Chen Shieh, Yi-Ju Lee, Gregory J Tsay, Yi-Ying Wu
Previous studies have indicated that paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting the ERK, p38, and NF-κB pathway. We modified paeonol to form a new compound, YPH-PA3, and found that it promoted osteoclastogenesis rather than inhibited it the way paeonol does. The aim of this study is to investigate the mechanisms involved in YPH-PA3-promoted osteoclastogenesis. YPH-PA3-promoted differentiation of RAW264.7 cells (human monocytes) into osteoclasts is activated through ERK/p38/JNK phosphorylation, affecting c-FOS, NF-κB, and NFATc2...
May 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29781138/comparison-of-the-progressive-resolution-optimizer-and-photon-optimizer-in-vmat-optimization-for-stereotactic-treatments
#15
Han Liu, Benjamin Sintay, Keith Pearman, Qingyang Shang, Lane Hayes, Jacqueline Maurer, Caroline Vanderstraeten, David Wiant
The photon optimization (PO) algorithm was recently released by Varian Medical Systems to improve volumetric modulated arc therapy (VMAT) optimization within Eclipse (Version 13.5). The purpose of this study is to compare the PO algorithm with its predecessor, progressive resolution optimizer (PRO) for lung SBRT and brain SRS treatments. A total of 30 patients were selected retrospectively. Previously, all the plans were generated with the PRO algorithm within Eclipse Version 13.6. In the new version of PO algorithm (Version 15), dynamic conformal arcs (DCA) were first conformed to the target, then VMAT inverse planning was performed to achieve the desired dose distributions...
May 20, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29780947/eplerenone-as-a-novel-treatment-for-persistent-subretinal-fluid-following-retinal-detachment-surgery
#16
Arezu Haghighi, Jiun Do, Hossein Ameri
Purpose: To describe the clinical course of a patient with persistent subretinal fluid (SRF) after primary scleral buckle surgery for a rhegmatogenous retinal detachment (RRD) repair who was subsequently treated with oral eplerenone for resolution of SRF. Observations: A 34 year-old-male presented with a large bullous macula-involving RRD of unknown duration and underwent primary scleral buckle and retinotomy for drainage of subretinal fluid (SRF). His post-operative course was characterized by persistent macular SRF for 1...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780505/macrophage-mediated-delivery-of-light-activated-nitric-oxide-prodrugs-with-spatial-temporal-and-concentration-control
#17
Michael A Evans, Po-Ju Huang, Yuji Iwamoto, Kelly N Ibsen, Emory M Chan, Yutaka Hitomi, Peter C Ford, Samir Mitragotri
Nitric oxide (NO) holds great promise as a treatment for cancer hypoxia, if its concentration and localization can be precisely controlled. Here, we report a "Trojan Horse" strategy to provide the necessary spatial, temporal, and dosage control of such drug-delivery therapies at targeted tissues. Described is a unique package consisting of (1) a manganese-nitrosyl complex, which is a photoactivated NO-releasing moiety (photoNORM), plus Nd3+ -doped upconverting nanoparticles (Nd-UCNPs) incorporated into (2) biodegradable polymer microparticles that are taken up by (3) bone-marrow derived murine macrophages...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780495/examining-the-chemical-and-structural-properties-that-influence-the-sensitivity-of-energetic-nitrate-esters
#18
Virginia W Manner, Marc J Cawkwell, Edward M Kober, Thomas W Myers, Geoff W Brown, Hongzhao Tian, Christopher J Snyder, Romain Perriot, Daniel N Preston
The sensitivity of explosives is controlled by factors that span from intrinsic chemical reactivity and chemical intramolecular effects to mesoscale structure and defects, and has been a topic of extensive study for over 50 years. Due to these complex competing chemical and physical elements, a unifying relationship between molecular framework, crystal structure, and sensitivity has yet to be developed. In order to move towards this goal, ideally experimental studies should be performed on systems with small, systematic structural modifications, with modeling utilized to interpret experimental results...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780017/metazoan-parasite-faunas-of-three-gobiid-species-actinopterygii-gobiidae-inhabiting-the-lower-k%C3%A4-z%C3%A4-l%C3%A4-rmak-delta-in-samsun-a-comparative-study
#19
Arzu Güven, Türkay Öztürk
OBJECTIVE: The aim of the present study was to investigate and compare metazoan parasite faunas of three gobiid fishes, Neogobius fluviatilis, Proterorhinus marmoratus, and Pomatoschistus marmoratus, inhabiting the Lower Kızılırmak Delta. METHODS: Fish specimens were caught using fishing nets and electroshock device. The fishes were transferred to the laboratory and examined under a dissecting microscope for metazoan parasites using conventional methods. The isolated parasites were fixed with 70% ethyl alcohol...
March 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29779925/the-application-of-p2psa-and-prostate-health-index-in-prostate-cancer-detection-a-prospective-cohort-in-a-tertiary-medical-center
#20
Yung-Ting Cheng, Chih-Hung Chiang, Yeong-Shiau Pu, Shih Ping Liu, Yu-Chuang Lu, Yi-Kai Chang, Hong-Chiang Chang, Kuo-How Huang, Yuan-Ju Lee, Po-Ming Chow, Shih-Chun Hung, Chao-Yuan Huang
BACKGROUND/PURPOSE: Prostate specific antigen (PSA) with low specificity that causes unnecessary prostate biopsies increases clinical morbidities, psychological stress, and medical expenses. We aimed to test the accuracy and cutoff value of Prostate Health Index (PHI) in men for prostate cancer detection. METHODS: We prospectively enrolled 213 men who underwent prostate biopsy with PSA≦10 ng/ml or abnormal findings on digital rectal examination. Total PSA (tPSA), free PSA (fPSA) and p2PSA levels were measured by serum samples before prostate biopsy...
May 17, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
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