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https://www.readbyqxmd.com/read/29166592/hiv-envelope-glycoform-heterogeneity-and-localized-diversity-govern-the-initiation-and-maturation-of-a-v2-apex-broadly-neutralizing-antibody-lineage
#1
Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, Andrew B Ward, Ian A Wilson, Dennis R Burton, Davey Smith, Sergei L Kosakovsky Pond, Pascal Poignard
Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop during natural infection can help guide the rational design of an HIV vaccine. Here, we described a bnAb lineage targeting the Env V2 apex and the Ab-Env co-evolution that led to development of neutralization breadth. The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino acids, among the shortest known for this class of Abs, and achieved breadth with only 10% nucleotide somatic hypermutation and no insertions or deletions...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166300/effect-of-age-on-high-t1-signal-intensity-of-the-dentate-nucleus-and-globus-pallidus-in-a-large-population-exposed-to-gadodiamide
#2
Carlo Cosimo Quattrocchi, Yuri Errante, Carlo Augusto Mallio, Luca Marinelli, Gianguido LoVullo, Gabriele Giannotti, Sabino Walter Della Sala, Aart J van der Molen, Bruno Beomonte Zobel
OBJECTIVE: The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS: A large, single-center retrospective population survey was designed and received institutional review board approval. Between January 2014 and December 2014, T1w signal intensity ratios were obtained from a large population of 2500 consecutive enhanced brain magnetic resonance imaging (MRI) scans...
November 21, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29165991/ultra-stretchable-graphene-based-molecular-barriers-for-chemical-protection-detection-and-actuation
#3
Po-Yen Chen, Mengke Zhang, Muchun Liu, Ian Y Wong, Robert H Hurt
A wide range of technologies require barrier films to impede molecular transport between the external environment and a desired internal microclimate. Adding stretchability to barrier films would enable new applications in packaging, textiles, and flexible devices, but classical barrier materials utilized dense, ordered molecular architectures that easily fracture under small tensile strain. Here, we show that textured graphene-based coatings can serve as ultra-stretchable molecular barriers expandable to 1500% areal strain through programmed unfolding that mimics the elasticity of polymers...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29164767/the-association-between-steatosis-and-diabetes-with-hepatocellular-carcinoma-in-non-genotype-3-chronic-hepatitis-c-patients
#4
Yi-Hao Yen, Ming-Tsung Lin, Fang-Ying Kuo, Kuo-Chin Chang, Ming-Chao Tsai, Po-Lin Tseng, Cheng-Kun Wu, Jung-Ting Lin, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen
BACKGROUND AND AIMS: Diabetes mellitus (DM) has been found to be strongly associated with an increased risk of hepatocellular carcinoma (HCC) among chronic hepatitis C (CHC) patients. Several studies have also found an association between metabolic steatosis and the risk of HCC in CHC patients, whether this latter association has been accounted for by the known relationship between DM and HCC is still unknown. METHODS: A cohort consisting of 976 non-genotype 3 patients histologically proven to have CHC and treated with interferon and ribavirin was studied...
November 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29164545/-sleep-quality-depression-anxiety-and-self-esteem-in-people-living-with-hiv-aids-plwha
#5
Hsiang-Chun Wu, Po-Liang Lu, Wen-Chuan Lin, Chien-Tai Yu, Ming-Chu Feng
BACKGROUND: HIV has become a chronic disease. Therefore, the mental health and sleep quality of people living with HIV/AIDS (PLWHA) have become increasingly important issues of concern. PURPOSE: To explore the sleep quality, depression, anxiety, and self-esteem of PLWHA and the correlation between sleep quality and various related mental-health factors. METHODS: A cross-sectional, descriptive, correlational study was conducted at a medical center in southern Taiwan in 2013-2014...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29164403/a-novel-photodynamic-therapy-based-drug-delivery-system-layered-on-a-stent-for-treating-cholangiocarcinoma
#6
Po-Chin Liang, Kai-Wen Huang, Chien-Chih Tung, Ming-Chu Chang, Fuh-Yu Chang, Jau-Min Wong, Yu-Ting Chang
This study aimed to investigate the drug delivery efficacy and bio-effectiveness of a novel photodynamic therapy (PDT)-matrix drug delivery system for cholangiocarcinoma (CCA). Metallic stents were coated with polyurethane (PU) as the first layer. A 2-hydroxyethyl methacrylate (2-HEMA)/ethylene glycol dimethacrylate (EGDMA)/benzoyl peroxide (BPO) layer and a poly(ethylene-co-vinyl acetate) (PEVA)/poly(n-butyl methacrylate) (PBMA)/polyvinylpyrrolidone K30 (K30) layer containing various concentrations of Photofrin were then incorporated onto the stent as the second and third layers...
November 22, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29164112/details-matter-noise-and-model-structure-set-the-relationship-between-cell-size-and-cell-cycle-timing
#7
Felix Barber, Po-Yi Ho, Andrew W Murray, Ariel Amir
Organisms across all domains of life regulate the size of their cells. However, the means by which this is done is poorly understood. We study two abstracted "molecular" models for size regulation: inhibitor dilution and initiator accumulation. We apply the models to two settings: bacteria like Escherichia coli, that grow fully before they set a division plane and divide into two equally sized cells, and cells that form a bud early in the cell division cycle, confine new growth to that bud, and divide at the connection between that bud and the mother cell, like the budding yeast Saccharomyces cerevisiae...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29163432/stratified-bacterial-and-archaeal-community-in-mangrove-and-intertidal-wetland-mudflats-revealed-by-high-throughput-16s-rrna-gene-sequencing
#8
Zhichao Zhou, Han Meng, Yang Liu, Ji-Dong Gu, Meng Li
The stratified distribution of bacterial and archaeal communities has been detected in many sediment profiles from various natural environments. A better understanding of microbial composition and diversity pattern in coastal mangrove wetlands in relation to physicochemical and spatial-temporal influences could provide more insights into the ecological functions of microbes in coastal wetlands. In this study, seasonal variations of microbial communities within sediment profiles from two sediment types (mangrove forest and intertidal mudflats) at three sampling locations in coastal Mai Po wetland were characterized using MiSeq high throughput sequencing and 16S rRNA quantitative PCR methods...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163381/functional-characterization-of-acinetobacter-baumannii-lacking-the-rna-chaperone-hfq
#9
Han-Yueh Kuo, Hsuan-Hao Chao, Po-Cheng Liao, Long Hsu, Kai-Chih Chang, Chi-Hua Tung, Chang-Hua Chen, Ming-Li Liou
The RNA chaperone Hfq is involved in the riboregulation of diverse genes via small RNAs. Recent studies have demonstrated that Hfq contributes to the stress response and the virulence of several pathogens, and the roles of Hfq vary among bacterial species. Here, we attempted to elucidate the role of Hfq in Acinetobacter baumannii ATCC 17978. In the absence of hfq, A. baumannii exhibited retarded cell growth and was highly sensitive to environmental stress, including osmotic and oxidative pressure, pH, and temperature...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163222/an-update-on-sec61-channel-functions-mechanisms-and-related-diseases
#10
REVIEW
Sven Lang, Stefan Pfeffer, Po-Hsien Lee, Adolfo Cavalié, Volkhard Helms, Friedrich Förster, Richard Zimmermann
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the protein translocon, which facilitates membrane integration or translocation of almost every newly synthesized polypeptide targeted to organelles of the endo- and exocytotic pathway. The translocon comprises the polypeptide-conducting Sec61 channel and several additional proteins and complexes that are permanently or transiently associated with the heterotrimeric Sec61 complex. This ensemble of proteins facilitates ER targeting of precursor polypeptides, modification of precursor polypeptides in transit through the Sec61 complex, and Sec61 channel gating, i...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162502/vagus-nerve-magnetic-modulation-facilitates-dysphagia-recovery-in-patients-with-stroke-involving-the-brainstem-a-proof-of-concept-study
#11
Wang-Sheng Lin, Chen-Liang Chou, Miao-Hsiang Chang, Yuh-Mei Chung, Fu-Gong Lin, Po-Yi Tsai
BACKGROUND & AIMS: Stroke involving the brainstem (SBS) causes severe oropharyngeal dysphagia (OD). Research on the therapeutic efficacy of vagus nerve modulation (VNM) by using repetitive transcranial magnetic stimulation (rTMS) in SBS patients with OD has been limited thus far. We aimed to assess the effect of VNM by using rTMS in improving swallowing function after SBS. METHOD: We conducted a sham-controlled, double-blinded, parallel pilot study in 28 SBS patients with OD randomly allocated to a real rTMS group (n = 13; TMSreal) or a sham group (n = 15; TMSsham)...
November 7, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29162281/targeted-next-generation-sequencing-identified-adamts5-as-novel-genetic-substrate-in-patients-with-bicuspid-aortic-valve
#12
Xiaoping Lin, Xianbao Liu, Lihan Wang, Jubo Jiang, Yinghao Sun, Qifeng Zhu, Zexin Chen, Yuxin He, Po Hu, Qiyuan Xu, Feng Gao, Yan Lin, Sanjay Jaiswal, Meixiang Xiang, Jian'an Wang
BACKGROUND: Bicuspid Aortic Valve (BAV) is the most common congenital heart disease, affecting >1% of the general population. Up to date, three genes, NOTCH1, GATA5 and SMAD6, have been linked to the isolated form of BAV. However, potential genetic determinants remain largely unknown in most BAV patients. MATERIAL AND METHODS: Targeted next-generation sequencing of 7 BAV candidate genes (NOTCH1, GATA5, SMAD6, NOS3, ADAMTS5, Alk2 and SMAD2) was performed in 32 BAV patients...
November 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29162108/reduced-suppressive-effect-of-%C3%AE-2-adrenoceptor-agonist-on-fibrocyte-function-in-severe-asthma
#13
Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo, Kian Fan Chung
BACKGROUND: Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of corticosteroids, and long acting β2-adrenergic receptor (AR) agonists (LABAs). We determined the effect of β2-AR agonists, alone or in combination with corticosteroids, on fibrocyte function. METHODS: Non-adherent non-T cells from peripheral blood mononuclear cells isolated from healthy subjects and patients with non-severe or severe asthma were treated with the β2-AR agonist, salmeterol, in the presence or absence of the corticosteroid dexamethasone...
November 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29160795/differential-expression-patterns-of-pleurotus-ostreatus-catalase-genes-during-developmental-stages-and-under-heat-stress
#14
Lining Wang, Xiangli Wu, Wei Gao, Mengran Zhao, Jinxia Zhang, Chenyang Huang
Catalases are ubiquitous hydrogen peroxide-detoxifying enzymes. They participate in fungal growth and development, such as mycelial growth and cellular differentiation, and in protecting fungi from oxidative damage under stressful conditions. To investigate the potential functions of catalases in Pleurotus ostreatus, we obtained two catalase genes from a draft genome sequence of P. ostreatus, and cloned and characterized them (Po-cat1 and Po-cat2). Po-cat1 (group II) and Po-cat2 (group III) encoded putative peptides of 745 and 528 amino acids, respectively...
November 21, 2017: Genes
https://www.readbyqxmd.com/read/29159180/the-influence-of-serum-prostate-specific-antigen-on-the-accuracy-of-magnetic-resonance-imaging-targeted-biopsy-versus-saturation-biopsy-in-patients-with-previous-negative-biopsy
#15
Chao-Hsiang Chang, Hung-Chieh Chiu, Wei-Ching Lin, Tzu-Lung Ho, Han Chang, Yi-Huei Chang, Chi-Ping Huang, Hsi-Chin Wu, Chi-Rei Yang, Po-Fan Hsieh
Objective: We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods: Overall 185 patients were enrolled. In the magnetic resonance imaging (MRI) group, 65 men underwent TB and SB. In the control group, 120 men underwent SB alone. The primary outcome was the difference in PCa detection rate between the MRI group and control group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29158826/label-free-biochips-for-accurate-detection-of-prostate-cancer-in-the-clinic-dual-biomarkers-and-circulating-tumor-cells
#16
Lung-Hsuan Pan, See-Tong Pang, Po-Yu Fang, Cheng-Keng Chuang, Hung-Wei Yang
Purpose: Early diagnosis of prostate cancer (PCa) is essential for the prevention of metastasis and for early treatment; therefore, we aimed to develop a simple, accurate, and multi-analyte assay system for early PCa diagnosis in this study. Experimental design: We fabricated three kinds of biochips then integrated into microfluidic device for simultaneous detection of vascularendothelial growth factor (VEGF), prostate-specific antigen (PSA), and PCa circulating tumor cells (CTC) in human serum for accurate diagnosis of PCa...
2017: Theranostics
https://www.readbyqxmd.com/read/29157675/corrigendum-to-loperamide-induced-cardiac-depression-is-enhanced-by-hyperglycemia-evidence-relevant-to-loperamide-abuse-archives-of-medical-research-48-2017-64-72
#17
Shih-Hsiang Lo, Ho-Shan Niu, Yung-Ze Cheng, Chiang-Shan Niu, Juei-Tang Cheng, Po-Ming Ku
No abstract text is available yet for this article.
May 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29156697/exploring-brusatol-as-a-new-anti-pancreatic-cancer-adjuvant-biological-evaluation-and-mechanistic-studies
#18
Zheng Lu, Zheng-Quan Lai, Albert W N Leung, Po Sing Leung, Zhao-Shen Li, Zhi-Xiu Lin
Pancreatic cancer is highly resistant to chemotherapeutic agents and is known to have a poor prognosis. The development of new therapeutic entities is badly needed for this deadly malignancy. In this study, we demonstrated for the first time that brusatol, a natural quassinoid isolated from a Chinese herbal medicine named Bruceae Fructus, possessed potent cytotoxic effect against different pancreatic adenocarcinoma cell lines. Its anti-pancreatic cancer effect was comparable to that of the first-line chemotherapeutic agents such as gemcitabine and 5-fluorouracil, with a more favorable safety profile...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156641/facile-control-of-the-porous-structure-of-larch-derived-mesoporous-carbons-via-self-assembly-for-supercapacitors
#19
Xin Zhao, Wei Li, Honglei Chen, Shoujuan Wang, Fangong Kong, Shouxin Liu
Mesoporous carbons have been successfully synthesized via self-assembly using larch-based resins as precursors and triblock copolymers as soft templates. The porous structure of mesoporous carbons can be tailored by adjusting the ratio of hydrophilic/hydrophobic (EO/PO) units owing to interfacial curvature. Interestingly, the porous structures show a distinct change from vortex-like to worm-like pores, to stripe-like pores, and to ordered two-dimensional hexagonal pores as the ratio of hydrophilic/hydrophobic units increases, indicating the significant effect of EO/PO ratio on the porous structure...
November 20, 2017: Materials
https://www.readbyqxmd.com/read/29155875/effect-of-long-term-irrigation-patterns-on-phosphorus-forms-and-distribution-in-the-brown-soil-zone
#20
Chang Liu, Xiuli Dang, Melanie A Mayes, Leilei Chen, Yulong Zhang
Continuous application of P fertilizers under different irrigation patterns can change soil phosphorus (P) chemical behavior and increase soil P levels that are of environmental concern. To assess the effect of long-term different irrigation patterns on soil P fractions and availability, this study examined sequential changes in soil organic P and inorganic P from furrow irrigation (FI), surface drip irrigation (SUR), and subsurface drip irrigation (SDI) in the brown soil zone (0-60 cm) during 1998 to 2011...
2017: PloS One
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