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https://www.readbyqxmd.com/read/29235404/understanding-the-interactions-of-different-substrates-with-wild-type-and-mutant-acylaminoacyl-peptidase-using-molecular-dynamics-simulations
#1
Jingxuan Zhu, Yan Wang, Xin Li, Weiwei Han, Li Zhao
Acylaminoacylpeptidase (AAP) belongs to peptidase protein family (POP), which can degrade amyloid β-peptide forms in the brains of patients and hence leads to Alzheimer's disease. And so, AAP is considered to be a novel target in the design of drugs against Alzheimer's disease. In this investigation, six molecular dynamics simulations were used to find that the interaction between the wild-type and R526V AAP with two different substrates (p-nitrophenylcaprylate and Ac-Leu-p-nitroanilide). Our results were as follows: firstly, Ac-Leu-p-nitroanilide bound to R526V AAP to form a more disordered loop (residues 552-562) in the α/β-hydrolase fold like of AAP, which caused an open and inactive AAP domain form, secondly, binding p-nitrophenylcaprylate and Ac-Leu-p-nitroanilide to AAP can decrease the flexibility of residues 225-250, 260-270 and 425-450, in which the ordered secondary structures may contain the suitable geometrical structure and so it is useful to serine attack...
December 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29234097/observation-of-deformation-twinning-and-martensitic-transformation-during-nanoindentation-of-a-transformation-induced-plasticity-steel
#2
Zhiping Xiong, Gilberto Casillas, Ahmed A Saleh, Shaogang Cui, Elena V Pereloma
For the first time, deformation twinning and martensitic transformation were observed in retained austenite in a low-alloyed transformation-induced plasticity steel using nanoindentation in conjunction with electron backscattering diffraction and transmission electron microscopy. Dislocation glide, martensite formation and deformation twinning were correlated to pop-ins and deviation from linearity in the load-displacement curve. Deformation twinning was found to enhance the stability of retained austenite...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234090/modeling-and-optimization-of-thermal-conductivity-and-viscosity-of-mnfe2o4-nanofluid-under-magnetic-field-using-an-ann
#3
Mohammad Amani, Pouria Amani, Alibakhsh Kasaeian, Omid Mahian, Ioan Pop, Somchai Wongwises
This research investigates the applicability of an ANN and genetic algorithms for modeling and multiobjective optimization of the thermal conductivity and viscosity of water-based spinel-type MnFe2O4 nanofluid. Levenberg-Marquardt, quasi-Newton, and resilient backpropagation methods are employed to train the ANN. The support vector machine (SVM) method is also presented for comparative purposes. Experimental results demonstrate the efficacy of the developed ANN with the LM-BR training algorithm and the 3-10-10-2 structure for the prediction of the thermophysical properties of nanofluids in terms of the significantly superior accuracy compared to developing the correlation and employing SVM regression...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227942/the-interaction-between-bacterial-abundance-and-selected-pollutants-concentration-levels-in-an-arctic-catchment-southwest-spitsbergen-svalbard
#4
Klaudia Kosek, Katarzyna Kozak, Krystyna Kozioł, Katarzyna Jankowska, Stanisław Chmiel, Żaneta Polkowska
Persistent organic pollutants (POPs) have been a topic of interest in environmental sciences for >60years. POPs in the Arctic have been investigated since the 1970s, when first atmospheric measurements revealed the presence of these pollutants in the polar regions. Major contaminant transport routes to the Arctic include atmospheric and oceanic transport, as well as inflow from rivers and sea ice. The sources of pollutants, such as industry, power generators, vehicle and ship exhausts, introduce the PAHs, phenols, formaldehyde or metals into the Arctic...
December 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29227932/an-overview-of-natural-antimicrobials-role-in-food
#5
REVIEW
Aurelia Magdalena Pisoschi, Aneta Pop, Cecilia Georgescu, Violeta Turcuş, Neli Kinga Olah, Endre Mathe
The present paper aims to review the natural food preservatives with antimicrobial properties emphasizing their importance for the future of food manufacturing and consumers' health. The extraction procedures applied to natural antimicrobials will be considered, followed by the description of some natural preservatives' antimicrobial mechanism of action, including (i) membrane rupture with ATP-ase activity inhibition, (ii) leakage of essential biomolecules from the cell, (iii) disruption of the proton motive force and (iiii) enzyme inactivation...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29222608/the-impact-of-subsidized-private-health-insurance-and-health-facility-upgrades-on-healthcare-utilization-and-spending-in-rural-nigeria
#6
Emily Gustafsson-Wright, Gosia Popławska, Zlata Tanović, Jacques van der Gaag
This paper analyzes the quantitative impact of an intervention that provides subsidized low-cost private health insurance together with health facility upgrades in Nigeria. The evaluation, which measures impact on healthcare utilization and spending, is based on a quasi-experimental design and utilizes three population-based household surveys over a 4-year period. After 4 years, the intervention increased healthcare use by 25.2 percentage points in the treatment area overall and by 17.7 percentage points among the insured...
December 8, 2017: International Journal of Health Economics and Management
https://www.readbyqxmd.com/read/29218226/hamman-s-syndrome-in-diabetic-ketoacidosis
#7
Alexandra Rose Pain, Josh Pomroy, Andrea Benjamin
Hamman's syndrome (spontaneous subcutaneous emphysema and pneumomediastinum) is a rare complication of diabetic ketoacidosis (DKA), with a multifactorial etiology. Awareness of this syndrome is important: it is likely underdiagnosed as the main symptom of shortness of breath is often attributed to Kussmaul's breathing and the findings on chest radiograph can be subtle and easily missed. It is also important to be aware of and consider Boerhaave's syndrome as a differential diagnosis, a more serious condition with a 40% mortality rate when diagnosis is delayed...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29218035/characterization-of-two-cryptic-plasmids-isolated-in-haiti-from-clinical-vibrio-cholerae-non-o1-non-o139
#8
Daniela Ceccarelli, Geneviève Garriss, Seon Y Choi, Nur A Hasan, Ramunas Stepanauskas, Mihai Pop, Anwar Huq, Rita R Colwell
We report the complete sequence of two novel plasmids, pSDH-1 and pSDH-2, isolated from clinical Vibrio cholerae non-O1/non-O139 during the early phase of the 2010 Haitian cholera epidemic. Plasmids were revealed by employing single-cell genomics and their genome content suggests self-mobilization and, for pSDH-2, a toxin-antitoxin (TA) system for plasmid stabilization was identified. The putative origin of replication of pSDH-2 was mapped suggesting it replicates following the ColE1 model of plasmid replication...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29216509/in-vitro-study-on-the-joint-hepatoxicity-upon-combined-exposure-of-cadmium-and-bde-209
#9
Lixin Wang, Miaomiao Zheng, Yu Gao, Jiansheng Cui
Joint toxicity is an important issue during the risk assessment of environmental pollutants. Contamination of heavy metals and persistent organic pollutants (POPs) under the environmental and biological settings poses substantial health risk to humans. Although previous studies demonstrated the co-occurrence of cadmium and decabrominated diphenyl ether (BDE-209) in environmental mediums, food chains and even human body, their potentially joint toxicities remain elusive thus far. Our investigation here with respect to the hepatotoxicity in vitro clearly demonstrated that combined exposure of cadmium and BDE-209 aggravated the injuries in hepatocytes, which was evidenced by the additive effects on the induction of remarkable morphological alternations, LDH release, cell apoptosis and necrosis, impairment of mitochondrial activity and transmembrane potential...
November 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29216357/parental-history-of-type-2-diabetes-abrogates-ethnic-disparities-in-key-glucoregulatory-indices
#10
Ebenezer Nyenwe, Ibiye Owei, Jim Wan, Sam Dagogo-Jack
Background: There are ethnic differences in glucoregulation and prevalence of type 2 diabetes but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African-Americans and Caucasians with or without parental diabetes. Design and Methods: Fifty subjects with parental diabetes (from the POP-ABC cohort) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and BMI...
December 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29214341/sternocostal-slipping-rib-syndrome
#11
Patrick C Bonasso, Shannon N Petrus, Samuel D Smith, Richard J Jackson
PURPOSE: Classical slipping rib syndrome (SRS) can be subclassified based on anatomical location. We describe our experience with three patients suffering from symptomatic sternocostal slipping rib syndrome (SCSRS), a much less common variant of SRS. METHODS: This was a retrospective review of patients with SRS from 1988 to 2016. Described is our experience. RESULTS: Of 44 patients identified with SRS, three patients underwent operations for SCSRS variant...
December 6, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29209805/selected-persistent-organic-pollutants-pops-in-water-of-river-niger-occurrence-and-distribution
#12
J P Unyimadu, O Osibanjo, J O Babayemi
This study assessed the levels and distribution of selected persistent organic pollutants (POPs) in water of River Niger. The selected POPs of interest were organochlorine pesticides (OCPs). Fifteen representative sites along River Niger: three each from Gurara River (tributary) in Niger State, Lokoja (confluence) in Kogi State, Onitsha in Anambra State, Brass and Nicolas Rivers (tributaries) in Bayelsa State were selected for sampling quarterly over a 24-month period. A total of 240 surface and bottom water samples were collected using Van Dorn water sampler in the eight quarters of 2008-2009...
December 6, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29207080/effect-of-puerarin-on-collagen-metabolism-of-fibroblasts-in-pelvic-tissue-of-women-with-pelvic-organ-prolapse
#13
Yang Li, Li Hong, Cheng Liu, Jie Min, Shasha Hong, Ming Hu, Yang Zhao, Qing Yang, Jianming Tang, Songming He
The aim of the present study was to investigate the protective effect of puerarin on pelvic organ prolapse (POP) and the underlying mechanisms that regulate the metabolism of human parametrial ligament fibroblasts (HPLFs). HPLFs obtained from the pelvic tissue of patients with (n=10) or without (n=8) POP during hysterectomy were isolated by enzymatic digestion and subsequently identified by immunocytochemistry in a previous study of the authors. Following this, cultured HPLFs were treated with 0.01, 0.10 or 1...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204486/fracture-of-the-femoral-adapter-bolt-and-taper-adapter-in-a-modern-rotating-platform-knee-arthroplasty
#14
Elexis C Baral, Alexander S McLawhorn, Timothy M Wright, Edwin P Su
A 58-year-old woman presented with onset of pain associated with a popping sound after a twisting motion 4 years after left total knee revision arthroplasty. She had a complex medical history, including a reported bone cement allergy, and presented to the hospital unable to bear weight. Plain radiographs revealed a broken femoral component, with the femoral metaphyseal sleeve separated from the distal articular component. During surgery, it was observed that the femoral adapter bolt and taper adapter had both fractured...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29202919/stakeholders-guidance-document-for-consumer-analytical-devices-with-a-focus-on-gluten-and-food-allergens
#15
Bert Popping, Laura Allred, François Bourdichon, Kurt Brunner, Carmen Diaz-Amigo, Patricia Galan-Malo, Markus Lacorn, Jennifer North, Salvatore Parisi, Adrian Rogers, Jennifer Sealy-Voyksner, Tricia Thompson, Jupiter Yeung
Until recently, analytical tests for food were performed primarily in laboratories, but technical developmentsnow enable consumers to use devices to test their food at home or when dining out. Current consumer devices for food can determine nutritional values, freshness, and, most recently, the presence of food allergens and substances that cause food intolerances. The demand for such products is driven by an increase in the incidence of food allergies, as well as consumer desire for more information about what is in their food...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29202904/a-global-reflection-on-food-allergen-regulations-management-and-analysis
#16
Carmen Diaz-Amigo, Bert Popping
No abstract text is available yet for this article.
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29202901/european-regulations-for-labeling-requirements-for-food-allergens-and-substances-causing-intolerances-history-and-future
#17
Bert Popping, Carmen Diaz-Amigo
Food allergens and intolerances have been diagnosed by doctors for decades, but have received heightened attention in the last two decades because diagnosis and awareness have increased. Consequently, regulators in many jurisdictions have addressed this topic by introducing labeling requirements for substances causing allergies and intolerance reactions in affected individuals. Mandatory labeling of food allergens allows persons suffering from these to make informed choices. However, regulations in some geographic areas have resulted in significant problems for manufacturers as well as consumers...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29202330/genetic-alterations-in-sporadic-triple-negative-breast-cancer
#18
Laura-Ancuta Pop, Roxana-Maria Cojocneanu-Petric, Valentina Pileczki, Gabriela Morar-Bolba, Alexandru Irimie, Vladimir Lazar, Claudio Lombardo, Angelo Paradiso, Ioana Berindan-Neagoe
BACKGROUND: Recent studies have aimed to identify gene mutation profiles to explain the cause of TNBC therapy limitations. METHODS: The purpose of our study was to use Next Generation Sequencing (NGS) of 46 genes with a well-defined role in cancer in a cohort of TNBC patients in order to identify novel markers that could lead to the development of strategic, adjuvant, gene-targeted therapies. RESULTS: A total of 118 gene mutations in 35 genes, 75 mutations in BRCA1 and 92 mutations in BRCA2 were identified...
December 1, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29200022/relationship-between-ventricular-arrhythmias-conduction-disorders-and-myocardial-fibrosis-in-patients-with-systemic-sclerosis
#19
Lucian Muresan, Irinel Oancea, Razvan Ovidiu Mada, Ana Petcu, Cristina Pamfil, Crina Muresan, Mirela Rinzis, Dana Pop, Dumitru Zdrenghea, Simona Rednic
BACKGROUND: Delayed-enhancement magnetic resonance imaging (DE-MRI) is a noninvasive diagnostic tool able to identify myocardial fibrosis. In patients with scleroderma, its relationship with arrhythmias and conduction disorders has not been fully explored. OBJECTIVES: The aim of this study was to evaluate the possible correlations between ventricular arrhythmias, conduction disorders, and myocardial fibrosis in patients with systemic sclerosis. METHODS: Thirty-six patients with diffuse or limited cutaneous scleroderma underwent 12-lead electrocardiogram (ECG), 24-hour Holter ECG monitoring, transthoracic echocardiography, and cardiac DE-MRI, with gadolinium administration in 33 patients...
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29198248/effects-of-dark-brooders-and-overhangs-on-free-range-use-and-behaviour-of-slow-growing-broilers
#20
L M Stadig, T B Rodenburg, B Reubens, B Ampe, F A M Tuyttens
Broiler chickens often make limited use of the free-range area. Range use is influenced by type of shelter available. Range use may possibly be improved by a more gradual transition from the house to the range and by using dark brooders (secluded warm, dark areas in the home pen) that mimic aspects of a broody hen and possibly reduce fearfulness. The aim of this study was to assess effects of dark brooders on fearfulness, free-range use and behaviour later in life. Another aim was to test the chickens' preference for shelter type and the effects of overhangs outside of the pop holes to provide a gradual transition to the range...
December 4, 2017: Animal: An International Journal of Animal Bioscience
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