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https://www.readbyqxmd.com/read/29040434/differential-processing-of-isolated-object-and-multi-item-pop-out-displays-in-lip-and-pfc
#1
Ethan M Meyers, Andy Liang, Fumi Katsuki, Christos Constantinidis
Objects that are highly distinct from their surroundings appear to visually "pop-out." This effect is present for displays in which: (1) a single cue object is shown on a blank background, and (2) a single cue object is highly distinct from surrounding objects; it is generally assumed that these 2 display types are processed in the same way. To directly examine this, we applied a decoding analysis to neural activity recorded from the lateral intraparietal (LIP) area and the dorsolateral prefrontal cortex (dlPFC)...
October 11, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29040216/depressive-symptoms-screening-in-postmenopausal-women-with-symptomatic-pelvic-organ-prolapse
#2
Fangfang Ai, Mou Deng, Meng Mao, Tao Xu, Lan Zhu
OBJECTIVE: This study aimed to investigate the prevalence of depressive symptoms in postmenopausal women with symptomatic pelvic organ prolapse (POP) and to identify the factors associated with depressive symptoms in this population. METHODS: We conducted a cross-sectional study involving postmenopausal women with symptomatic POP who visited the Center of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, between July 2016 and March 2017...
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29035940/perspectives-on-hypertension-s-prevalence-treatment-and-control-in-a-high-cardiovascular-risk-east-european-country-data-from-the-sephar-iii-survey
#3
Maria Dorobantu, Oana-Florentina Tautu, Doina Dimulescu, Crina Sinescu, Paul Gusbeth-Tatomir, Catalina Arsenescu-Gerogescu, Florin Mitu, Daniel Lighezan, Calin Pop, Katalin Babes, Alina Giuca, Ileana Branza, Mihaela Udrescu, Valeria Herdea, Roxana Darabont
OBJECTIVES: To estimate the trend in arterial hypertension's prevalence, awareness, treatment, and control in Romania, starting from the latest national survey Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in Romania III that has a crucial importance for the development of prevention strategies at national level. METHODS: A representative sample of 1970 Romanian adults (mean age 48.38 years, age range 18-80 years, 52.5% women, 72...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29034209/bridge-induced-translocation-between-nup145-and-top2-yeast-genes-models-the-genetic-fusion-between-the-human-orthologs-associated-with-acute-myeloid-leukemia
#4
Valentina Tosato, Nicole West, Jan Zrimec, Dmitri V Nikitin, Giannino Del Sal, Roberto Marano, Michael Breitenbach, Carlo V Bruschi
In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions. We previously developed a system named bridge-induced translocation (BIT) that allows linking together two different chromosomes exploiting the strong endogenous homologous recombination system of the yeast Saccharomyces cerevisiae. The BIT system generates a heterogeneous population of cells with different aneuploidies and severe aberrant phenotypes reminiscent of a cancerogenic transformation...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29033548/the-new-era-of-nanotechnology-an-alternative-to-change-cancer-treatment
#5
REVIEW
Ancuta Jurj, Cornelia Braicu, Laura-Ancuta Pop, Ciprian Tomuleasa, Claudia Diana Gherman, Ioana Berindan-Neagoe
In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29033376/evolution-of-prophylaxis-protocols-for-venous-thromboembolism-in-neurosurgery-results-from-a-prospective-comparative-study-on-low-molecular-weight-heparin-elastic-stockings-and-intermittent-pneumatic-compression-devices
#6
Salvatore Chibbaro, Helene Cebula, Julien Todeschi, Marco Fricia, Doris Vigouroux, Houssem Abid, Houssen Kourbanhoussen, Raoul Pop, Beniamino Nannavecchia, Arthur Gubian, Lara Prisco, Gianfranco K I Ligarotti, Francois Proust, Mario Ganau
BACKGROUND: The incidence of venous thromboembolism (VT) in neurosurgical practice is astonishingly high representing a major cause of morbidity and mortality. Prophylaxis strategies include elastic stockings (ES), low-molecular weight heparin (LMWH) and intermittent pneumatic compression (IPC) devices. OBJECTIVE: To assess the safety and efficacy of two different VT prophylaxis protocols implemented in a European neurosurgical centre. METHODS: All patients admitted for neurosurgical intervention between 2012 and 2016 were stratified in low-, moderate- and high-risk of VT, and received a combination of ES and LMWH...
October 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29033114/a-bibliometric-and-social-network-analysis-of-pelvic-organ-prolapse-during-2007-2016
#7
Feng Huang, Quan Zhou, Bing-Jie Leng, Qiao-Ling Mao, Li-Min Zheng, Man-Zhen Zuo
BACKGROUND: Pelvic organ prolapse (POP) seriously affects the life quality of old females. In the present work, we described the knowledge structure of POP in a macroscopic view, and summarized the recent research focus. METHODS: Candidates were identified through reading and screening publications from PubMed database with a MeSH term of "pelvic organ prolapse" during 2007-2016. Relevant journals and journal-affiliated countries were extracted, and essential information, such as the number of publication of each year, first authors and MeSH/subheading words, was analyzed with BICOMB...
October 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29030882/accelerated-multicontrast-volumetric-imaging-with-isotropic-resolution-for-improved-peri-infarct-characterization-using-parallel-imaging-low-rank-and-spatially-varying-edge-preserving-sparse-modeling
#8
Li Zhang, Peng Lai, Mihaela Pop, Graham A Wright
PURPOSE: To achieve consistent effectiveness in reconstruction of fine image features for cases of varying contrast-to-noise ratio (CNR) to facilitate translating accelerated multicontrast volumetric imaging with isotropic resolution toward clinical utility in peri-infarct characterization. THEORY AND METHODS: A low-rank and spatially varying edge-preserving constrained compressed sensing parallel imaging reconstruction method (CP-LASER) is developed to effectively preserve contrast of small-scale structures for highly accelerated multicontrast volumetric imaging in CNR-limited scenarios...
October 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29030152/identification-of-microbiota-dynamics-using-robust-parameter-estimation-methods
#9
Matthias Chung, Justin Krueger, Mihai Pop
The compositions of in-host microbial communities (microbiota) play a significant role in host health, and a better understanding of the microbiota's role in a host's transition from health to disease or vice versa could lead to novel medical treatments. One of the first steps toward this understanding is modeling interaction dynamics of the microbiota, which can be exceedingly challenging given the complexity of the dynamics and difficulties in collecting sufficient data. Methods such as principal differential analysis, dynamic flux estimation, and others have been developed to overcome these challenges...
October 10, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/29029071/visual-cortex-limits-pop-out-in-the-superior-colliculus-of-awake-mice
#10
Mehran Ahmadlou, Azadeh Tafreshiha, J Alexander Heimel
We detect objects more readily if they differ from their surroundings in motion, color, or texture. This increased saliency is thought to be related to increased responses in the visual cortex. The superior colliculus is another brain area involved in vision and especially in directing gaze and attention. In this study, we show that differences in texture orientation also increase responses in the superficial layers of the superior colliculus that receive retinal and cortical input. We found that gratings evoke more neural response when surrounded by orthogonal gratings than when surrounded by parallel gratings, particularly in the awake mouse...
September 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29028198/a-benchmark-dataset-and-saliency-guided-stacked-autoencoders-for-video-based-salient-object-detection
#11
Jia Li, Changqun Xia, Xiaowu Chen
Image-based salient object detection (SOD) has been extensively studied in past decades. However, video-based SOD is much less explored due to the lack of large-scale video datasets within which salient objects are unambiguously defined and annotated. Toward this end, this paper proposes a video-based SOD dataset that consists of 200 videos. In constructing the dataset, we manually annotate all objects and regions over 7,650 uniformly sampled keyframes and collect the eye-tracking data of 23 subjects who free-view all videos...
October 12, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29027694/can-we-evaluate-hiatal-ballooning-by-measuring-the-anteroposterior-diameter-with-2-dimensional-translabial-ultrasonography
#12
Lieming Wen, Qichang Zhou
OBJECTIVES: To analyze the association between the anteroposterior hiatal diameter and pelvic organ prolapse and to determine whether 2-dimensional translabial ultrasonography can evaluate hiatal ballooning by measuring the anteroposterior diameter. METHODS: This study was a retrospective analysis of 312 women seen for lower urinary tract symptoms or pelvic organ prolapse between December 2014 and July 2016. All women had an International Continence Society (ICS) Pelvic Organ Prolapse Quantification (POP-Q) system examination and 4-dimensional translabial ultrasonography...
October 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29024913/retrospective-study-on-de-novo-postoperative-urinary-incontinence-after-pelvic-organ-prolapse-surgery
#13
Aiste Ugianskiene, Niels Kjærgaard, Anna Sofie Inger Lindquist, Thomas Larsen, Karin Glavind
OBJECTIVE: Reported incidences of de novo urinary incontinence (UI) following pelvic organ prolapse (POP) surgery in preoperatively continent women vary between 2% and 43%. The aim of this study was to investigate the incidence and the types of de novo UI and differences between operations in different compartments. STUDY DESIGN: Retrospective study of 678 women with POP surgery using native tissue repair during a 3-year period. Patients completed three modified prolapse questions from the International Consultation on Incontinence-Vaginal Symptoms (ICIQ-VS) and the International Consultation on Incontinence Questionnaire- Urinary Incontinence Short Form (ICIQ-UI SF) before undergoing surgery and 3 months postoperatively...
October 4, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29024695/cops-and-pops-patrol-inflammasome-activation
#14
REVIEW
Mohanalaxmi Indramohan, Christian Stehlik, Andrea Dorfleutner
Sensing and responding to pathogens and tissue damage is a core mechanism of innate immune host defense and inflammasomes represent a central cytosolic pattern recognition receptor (PRR) pathway leading to the generation of the pro-inflammatory cytokines IL-1β and IL-18 and pyroptotic cell death that causes the subsequent release of danger signals to propagate and perpetuate inflammatory responses. While inflammasome activation is essential for host defense, deregulated inflammasome responses and excessive release of inflammatory cytokines and danger signals are linked to an increasing spectrum of inflammatory diseases...
October 9, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29023720/a-field-test-of-the-use-of-pop-off-data-storage-tags-in-freshwater-fishes
#15
G D Raby, T B Johnson, S T Kessel, T J Stewart, A T Fisk
In the present study, pop-off data storage tags (pDST) without any transmitting capabilities were attached to 118 adult salmonids in a 19 000 km(2) freshwater system (Lake Ontario). The 9·3 cm long cylindrical tags were externally attached to fishes using a backpack-style harness, set to record pressure (dBar ≈ depth in m) and temperature every 70 s (and at some key times, every 5 s) and programmed to release from the harness and float to the surface after c. 1 year. Recapture of the bright-orange tags for data retrieval relied on members of the public finding tags on shore, or on anglers capturing fishes with tags attached and using the contact information displayed on each tag to mail tags to the research team in exchange for a monetary reward...
October 12, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29022645/the-significance-of-trip11-and-t3-signaling-pathway-in-renal-cancer-progression-and-survival-of-patients
#16
Piotr Popławski, Agnieszka Piekiełko-Witkowska, Alicja Nauman
INTRODUCTION: TRIP11 is a multifunctional protein localizing either to Golgi apparatus, acting as a golgin, or in the nucleus, acting as coactivator of transcription mediated by thyroid hormone receptor (THR) and hypoxia induced factor (HIF). Triiodothyronine (T3) regulates nuclear localization of TRIP11 by inducing its phosphorylation. The exact mechanism of this regulation unknown. The expressions of THR and HIF are disturbed in various cancers, including renal cell cancer (RCC). In this study we aimed to analyze: 1) the mechanism of T3-dependent subcellular localization of TRIP11; 2) the significance of TRIP11 and T3 signaling pathway in RCC progression...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022199/injuries-in-children-with-autism-spectrum-disorder-study-to-explore-early-development-seed
#17
Carolyn DiGuiseppi, Susan E Levy, Katherine R Sabourin, Gnakub N Soke, Steven Rosenberg, Li-Ching Lee, Eric Moody, Laura A Schieve
This study examined caregiver-reported medically-attended injuries among 30-68 month old children with autism spectrum disorder (ASD) compared to general population (POP) and non-ASD developmental disorders (DD) controls in the Study to Explore Early Development. Injuries were common in ASD cases (32.3%) as well as POP (30.2%) and DD (27.8%) controls; most resulted in an emergency visit or hospitalization. After accounting for sociodemographic, health, IQ and behavior differences, odds of injury in ASD cases were significantly higher than DD controls but similar to POP controls...
October 11, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29019880/the-effect-of-water-immersion-delivery-on-the-strength-of-pelvic-floor-muscle-and-pelvic-floor-disorders-during-postpartum-period-an-experimental-study
#18
Yun Zhao, Mei Xiao, Fei Tang, Wan Tang, Heng Yin, Guo-Qiang Sun, Yin Lin, Yong Zhou, Yan Luo, Lu-Man Li, Zhi-Hua Tan
BACKGROUND: Water immersion delivery is a non-pharmacological approach to ease labor pain. This paper aims to investigate the effect of water immersion delivery on increasing strength of pelvic floor muscle (PFM) and relieving pelvic floor disorders (PFDs) during postpartum period. METHODS: A total of 2749 vaginal-delivery primiparas in postpartum 6-8 weeks were selected as research objects. Based on the modes of delivery, 600 patients were assigned into water immersion delivery group, 2149 were assigned into conventional delivery group...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019041/remediation-of-persistent-organic-pollutant-contaminated-soil-using-biosurfactant-enhanced-electrokinetics-coupled-with-a-zero-valent-iron-activated-carbon-permeable-reactive-barrier
#19
Yuchao Sun, Ke Gao, Yun Zhang, Hua Zou
Zero-valent iron/activated carbon (Fe/C) particles can degrade persistent organic pollutants via micro-electrolysis and therefore, they may be used to develop materials for permeable reactive barriers (PRBs). In this study, surfactant-enhanced electrokinetics (EK) was coupled with a Fe/C-PRB to treat phenanthrene (PHE) and 2,4,6-trichlorophenol (TCP) co-contaminated clay soil. An environment-friendly biosurfactant, rhamnolipid, was selected as the solubility-enhancing agent. Five bench-scale tests were conducted to investigate the performance of EK-PRB on PHE and TCP removal from soil as well as the impact of pH and rhamnolipid concentration...
October 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29017533/persistent-organic-pollutants-and-mortality-in-the-united-states-nhanes-1999-2011
#20
Kristiann Fry, Melinda C Power
BACKGROUND: Persistent organic pollutants (POPs) are environmentally and biologically persistent chemicals that include polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFASs), polychlorinated biphenyls (PCBs), and organochlorine (OC) pesticides. Currently, data on the associations between exposure to POPs and the risk of mortality in the U.S. population is limited. Our objective was to determine if higher exposure to POPs is associated with greater risk of all-cause, cancer, heart/cerebrovascular disease, or other-cause mortality...
October 10, 2017: Environmental Health: a Global Access Science Source
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