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https://www.readbyqxmd.com/read/29783084/organochlorine-pesticides-ocps-and-polychlorinated-biphenyls-pcbs-in-cyprinidae-fish-towards-hints-of-their-arrangements-using-advanced-classification-methods
#1
Snježana Herceg Romanić, Gordana Vuković, Darija Klinčić, Marijana Matek Sarić, Ivan Župan, Davor Antanasijević, Aleksandar Popović
To tackle the ever-present global concern regarding human exposure to persistent organic pollutants (POPs) via food products, this study strived to indicate associations between organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in lake-fish tissue depending on the species and sampling season. Apart from the monitoring initiatives recommended in the Global Monitoring Plan for POPs, the study discussed 7 OCPs and 18 PCB congeners determined in three Cyprinidae species (rudd, carp, and Prussian carp) from Vransko Lake (Croatia), which are widely domesticated and reared as food fish across Europe and Asia...
May 18, 2018: Environmental Research
https://www.readbyqxmd.com/read/29782183/effect-of-cabbage-wraps-on-the-reduction-of-post-traumatic-knee-exudates-in-men
#2
Jacek Dygut, Monika Piwowar, Kinga Fijałkowska, Ibeth Guevara, Robert Jakubas, Gustaw Gonzales, Krzysztof Popławski, Anna Strokowska, Hanna Wikariak, Wiktor Jurkowski
OBJECTIVES: The study investigates measurable effects of cabbage leaf wraps on post-traumatic knee injury exudate absorption in men. DESIGN: Case-control experiment on the same group of patients (before and after treatment). SETTINGS/LOCATION: One academic center and two hospitals. SUBJECTS: The study was carried out on a group of patients with different degrees of injury severity in the acute stage of the knee injury who were divided into three groups based on the width of suprapatellar recess gap (3-5 mm in group 1, 6-10 mm in group 2, and 11 mm or more in group 3) as assessed by ultrasonography...
May 21, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29781073/the-impact-of-concurrent-pelvic-organ-prolapse-reconstructive-surgery-on-midurethral-sling-procedure-outcome
#3
Buğra Çoşkun, Orhan S Aksakal, Bora Çoşkun, Engin Yurtçu, Mehmet Özgür Akkurt, Özgül Kafadar, Melike Doğanay
OBJECTIVES: To evaluate the effect of concurrent pelvic organ prolapse (POP) reconstructive surgery on midurethral sling (MUS) procedure outcome. MATERIAL AND METHODS: The present retrospective study included 300 women with urodynamically diagnosed stress urinary incontinence that underwent MUS procedures with or without concurrent POP reconstructive surgery. Patients were divided into four groups according to the performed surgery; 1) transobturator tape (TOT), 2) TOT with POP surgery (anterior colporrhaphy, posterior colporrhaphy and vaginal hysterectomy), 3) tension free vaginal tape (TVT), 4) TVT with POP surgery...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29779956/targeted-covalent-inhibition-of-prolyl-oligopeptidase-pop-discovery-of-sulfonylfluoride-peptidomimetics
#4
Salvador Guardiola, Roger Prades, Laura Mendieta, Arwin J Brouwer, Jelle Streefkerk, Laura Nevola, Teresa Tarragó, Rob M J Liskamp, Ernest Giralt
Prolyl oligopeptidase (POP), a serine protease highly expressed in the brain, has recently emerged as an enticing therapeutic target for the treatment of cognitive and neurodegenerative disorders. However, most reported inhibitors suffer from short duration of action, poor protease selectivity, and low blood-brain barrier (BBB) permeability, which altogether limit their potential as drugs. Here, we describe the structure-based design of the first irreversible, selective, and brain-permeable POP inhibitors. At low-nanomolar concentrations, these covalent peptidomimetics produce a fast, specific, and sustained inactivation of POP, both in vitro and in human cells...
May 7, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29778940/pcbs-and-organochlorine-pesticides-in-indoor-environments-a-comparison-of-indoor-contamination-in-canada-and-czech-republic
#5
Ondrej Audy, Lisa Melymuk, Marta Venier, Simon Vojta, Jitka Becanova, Kevin Romanak, Martina Vykoukalova, Roman Prokes, Petr Kukucka, Miriam L Diamond, Jana Klanova
Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are restricted compounds that are ubiquitously detected in the environment, including indoor matrices such as air and residential dust. We report concentrations of PCBs and selected OCPs in indoor air and dust from homes in Canada (23 homes) and Czech Republic (20 homes). Indoor air concentrations of PCBs and OCPs were ∼10 times higher than that outdoors. PCB concentrations of ∼450 ng/m3 were similar in both countries, higher in homes built before the restrictions on PCBs, and had congener profiles consistent with PCB mixtures manufactured or used in each country...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29778681/portable-x-ray-fluorescence-for-the-detection-of-pop-bfrs-in-waste-plastics
#6
Martin Sharkey, Mohamed Abou-Elwafa Abdallah, Daniel S Drage, Stuart Harrad, Harald Berresheim
The purpose of this study was to establish the efficacy of portable X-ray fluorescence (XRF) instrumentation as a screening tool for a variety of end of life plastics which may contain excess amounts of brominated flame retardants (BFRs), in compliance with European Union (EU) and United Nations Environment Programme (UNEP) legislative limits (low POP concentration limits - LPCLs). 555 samples of waste plastics were collected from eight waste and recycling sites in Ireland, including waste electrical and electronic equipment (WEEE), textiles, polyurethane foams (PUFs), and expanded polystyrene foams...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778059/tracking-pollutants-in-dietary-fish-oil-from-ocean-to-table
#7
Sheng-Xiang Sun, Xue-Ming Hua, Yun-Yun Deng, Yun-Ni Zhang, Jia-Min Li, Zhao Wu, Samwel Mchele Limbu, Da-Sheng Lu, Hao-Wen Yin, Guo-Quan Wang, Rune Waagbø, Frøyland Livar, Mei-Ling Zhang, Zhen-Yu Du
Dietary fish oil used in aquafeed transfers marine pollutants to farmed fish. However, the entire transfer route of marine pollutants in dietary fish oil from ocean to table fish has not been tracked quantitatively. To track the entire transfer route of marine pollutants from wild fish to farmed fish through dietary fish oil and evaluate the related human health risks, we obtained crude and refined fish oils originating from the same batch of wild ocean anchovy and prepared fish oil-containing purified aquafeeds to feed omnivorous lean Nile tilapia and carnivorous fatty yellow catfish for eight weeks...
May 16, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29777821/regional-cardiac-function-analysis-from-tagged-mri-images-comparison-of-techniques-harmonic-phase-harp-versus-sinusoidal-modeling-sinmod-analysis
#8
El-Sayed H Ibrahim, Jadranka Stojanovska, Azza Hassanein, Claire Duvernoy, Pierre Croisille, Rodica Pop-Busui, Scott D Swanson
Cardiac MRI tagging is a valuable technique for evaluating regional heart function. Currently, there are a number of different techniques for analyzing the tagged images. Specifically, k-space-based analysis techniques showed to be much faster than image-based techniques, where harmonic-phase (HARP) and sine-wave modeling (SinMod) stand as two famous techniques of the former group, which are frequently used in clinical studies. In this study, we compared HARP and SinMod and studied inter-observer variability between the two techniques for evaluating myocardial strain and apical-to-base torsion in numerical phantom, nine healthy controls, and thirty diabetic patients...
May 16, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29777272/modified-extraperitoneal-uterosacral-ligament-suspension-for-prevention-of-vault-prolapse-after-vaginal-hysterectomy
#9
Manidip Pal, Soma Bandyopadhyay
INTRODUCTION AND HYPOTHESIS: During vaginal hysterectomy, extraperitoneal uterosacral ligament suspension (ULS) bites can be taken before removing the uterus. We evaluated this modified extraperitoneal ULS for vault prolapse prevention. METHODS: Study period was 3.5 years. Fifty-one women with third- and fourth-degree prolapse were enrolled. An inverted V incision was made on the anterior vaginal wall and continued as a semicircular incision on the posterior vaginal wall...
May 17, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29777251/association-of-anterior-and-posterior-occlusal-planes-with-different-angle-and-skeletal-classes-in-permanent-dentitions-a-lateral-cephalometric-radiograph-study
#10
Aleš Čelar, Ekrem Tafaj, Alexandra Graf, Stefan Lettner
OBJECTIVES: Malocclusions affect about two-thirds of the population and orthodontic treatment is justified in 65% of these. However, the associations between anterior and posterior occlusal plane (AOP, POP) inclinations and Angle classification are lacking. PATIENTS AND METHODS: In a retrospective study, lateral cephalometric radiograph tracings of 230 previously untreated Caucasians, aged 13 to 49 years, yielded inclines of the bisector occlusal plane, AOP, and POP...
May 17, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/29777050/the-yeast-telomerase-recruitment-module-requires-a-specific-rna-architecture
#11
Nancy Laterreur, Bruno Lemieux, Hannah Neumann, Jean-Christophe Berger-Dancause, Daniel Lafontaine, Raymund J Wellinger
Telomerases are ribonucleoprotein (RNP) enzymes that are related to reverse transcriptases. While they maintain genome stability, their composition varies significantly between species. Yeast telomerase RNPs contain an RNA that is comparatively large and its overall folding shows long helical segments with distal functional parts. Here we investigated the essential stem IVc module of the budding yeast telomerase RNA, called Tlc1. The distal part of stem IVc includes a conserved sequence element CS2a and structurally conserved features to which bind the Pop1/Pop6/Pop7 proteins and which together function analogously to the P3 domains of the RNase P/MRP RNPs...
May 18, 2018: RNA
https://www.readbyqxmd.com/read/29775944/alterations-of-cytochrome-p450-and-the-occurrence-of-persistent-organic-pollutants-in-tilapia-caged-in-the-reservoirs-of-the-igua%C3%A3-u-river
#12
F Y Yamamoto, G D Diamante, M S Santana, D R Santos, R Bombardeli, C C Martins, C A Oliveira Ribeiro, D Schlenk
Environmental chemicals originating from human activities, such as persistent organic pollutants (POPs), may interfere with the endocrine system of aquatic organisms. The effect of these chemicals on biota and human populations is of high public concern but remains poorly understood, especially in aquatic environments of South America. The aim of this study was to investigate the bioavailability of POPs and the related effects in caged male tilapia (Oreochromis niloticus) in four cascading reservoirs of the Iguaçu River, Southern Brazil...
May 15, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29775424/optimized-yeast-based-in-vitro-bioassay-for-determination-of-estrogenic-and-androgenic-activity-of-hydroxylated-methoxylated-metabolites-of-bdes-cbs-and-related-lipophilic-organic-pollutants
#13
Marek Roszko, Marta Kamińska, Krystyna Szymczyk, Katarzyna Piasecka-Jóźwiak, Beata Chabłowska
Persistent organic pollutants (POPs) are known to show endocrine disrupting (ED) activity, including interactions with hormone receptors. The aim of this work was to develop a bioassay applicable for evaluation of ED potency of highly lipophilic metabolites of POPs. To that end, a yeast-based bio-assay protocol was used. Estrogenic / androgenic activity of some native brominated biphenyl ethers (BDEs) / chlorinated biphenyls (CBs), and their hydroxylated / methoxylated metabolites was assessed. Since data (including potency compared to reference native hormones) obtained using different protocols vary, the possibility that yeast transforms POPs into some more potent compounds was first checked; it seems that no such transformation is important from the test applicability standpoint...
May 18, 2018: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29774820/robotic-sacral-colpopexy
#14
Charles R Powell, Isamu Tachibana, Bridget Eckrich, Jeffrey Rothenberg, Jon Hathaway
INTRODUCTION AND OBJECTIVE: Robot-assisted sacral colpopexy (RASC) is a fast growing approach for surgeons treating patients with advanced stage pelvic organ prolapse (POP). Open abdominal sacral colpopexy has been the gold standard for advanced POP but requires longer hospital stays and a much larger incision. The indications, preoperative preparation, operative positioning, and operative steps are detailed, and an accompanying video shows the approach. METHODS: RASC can be broken down into 11 steps and the reader will be able to reference the article to the corresponding portion of the video...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29765504/polyphenolic-compounds-antioxidant-and-cardioprotective-effects-of-pomace-extracts-from-feteasc%C3%A4-neagr%C3%A4-cultivar
#15
Ştefania Silvia Balea, Alina Elena Pârvu, Nastasia Pop, Fernando Zamora Marín, Marcel Pârvu
Grape pomace is a potential source of natural antioxidant agents. Phenolic compounds and antioxidant and cardioprotective properties of fresh and fermented pomace extracts obtained from Vitis vinifera L. red variety Fetească neagră grown in Romania in 2015 were investigated. Grape pomace extracts total phenolic index, total tannins, total anthocyanins, proanthocyanidins, flavan-3-ol monomers, stilbenes, and DPPH free radical scavenger were measured. The effect of a seven-day pretreatment with grape pomace extracts on the isoprenaline-induced infarct-like lesion in rats was assessed by ECG monitoring, serum levels of creatine kinase, aspartate transaminase, and alanine transaminase...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29759495/in-vitro-validation-of-the-lesion-size-index-to-predict-lesion-width-and-depth-after-irrigated-radiofrequency-ablation-in-a-porcine-model
#16
Vittorio Calzolari, Luca De Mattia, Stefano Indiani, Martino Crosato, Alberto Furlanetto, Claudia Licciardello, Paolo Antonio Maria Squasi, Zoran Olivari
OBJECTIVES: In an in vitro model, the authors tested the hypotheses that: 1) lesion dimensions correlate with lesion size index (LSI); and 2) LSI could predict lesion dimensions better than power, contact force (CF), and force-time integral (FTI). BACKGROUND: When performing radiofrequency (RF) catheter ablation for cardiac arrhythmias, reliable predictors of lesion quality are lacking. The LSI is a multiparametric index incorporating time, power, CF, and impedance recorded during ablation...
October 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29758876/selection-of-passerine-birds-as-bio-sentinel-of-persistent-organic-pollutants-in-terrestrial-environment
#17
Ling Mo, Xiaobo Zheng, Yuxin Sun, Lehuan Yu, Xiaojun Luo, Xiangrong Xu, Xiaoquan Qin, Yongli Gao, Bixian Mai
A broad suite of persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and dichlorodiphenyltrichloroethane (DDT) and its metabolites, were analyzed in pectoral muscle of eight terrestrial passerine bird species from an extensive e-waste recycling site in South China. Concentrations of PCBs, PBDEs, and DDTs in bird samples ranged from 1260-279,000, 121-14,200, and 31-7910ng/g lipid weight, respectively. Insectivorous birds had significantly higher levels of PCBs, PBDEs, and DDTs than those in granivorous birds...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29757572/comparison-of-the-kelly-s-plication-and-tot-simultaneously-with-vaginal-hysterectomy-on-the-incontinence-and-sexual-functions
#18
Neslihan Bayramoglu Tepe, Omer Bayrak, Huseyin Caglayan Ozcan, Mete Gurol Ugur, Ilker Seckiner
PURPOSE: To compare the effect of vaginal hysterectomy-anterior/posterior colporrhaphy with Kelly's plication(VH-KP), versus vaginal hysterectomy-anterior/posterior colporrhaphy-transobturator tape(VH-TOT) surgeries on incontinence, quality of life, and sexual functions in patients with pelvic organ prolapse(POP), and concurrent obvious stress urinary incontinence(SUI). MATERIALS AND METHODS: Between 2013 and 2017, fifty patients treated with VH-KP(n = 25), and VH-TOT(n = 25) due to POP and SUI, were evaluated prospective consecutively...
May 5, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29755337/influence-of-apoe-and-rnf219-on-behavioral-and-cognitive-features-of-female-patients-affected-by-mild-cognitive-impairment-or-alzheimer-s-disease
#19
Alessandra Mosca, Samantha Sperduti, Viorela Pop, Domenico Ciavardelli, Alberto Granzotto, Miriam Punzi, Liborio Stuppia, Valentina Gatta, Francesca Assogna, Nerisa Banaj, Fabrizio Piras, Federica Piras, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi
The risk for Alzheimer's disease (AD) is associated with the presence of the
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29753214/snap-crack-and-pop-of-explosive-fruit
#20
REVIEW
Anahit Galstyan, Angela Hay
There is an increasing appreciation for the role of physical forces in plant development. Mechanics are fundamental to how explosive fruit eject their seeds, and recent studies have successfully combined mechanics with developmental genetics to help explain how these dispersal traits are produced and how they evolved. Computational modeling is used more and more to address developmental questions, and explosive fruit are particularly good systems for combining biology and modeling approaches. Finite element models have been recently used to explore questions such as: Why do touch-me-not species with similar fruits, differ so much in how efficiently they transfer stored energy to eject seeds? And how do popping cress fruits use the expansive force of turgor pressure for tissue contraction?...
May 9, 2018: Current Opinion in Genetics & Development
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