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https://www.readbyqxmd.com/read/28098502/united-kingdom-national-paediatric-bilateral-project-results-of-professional-rating-scales-and-parent-questionnaires
#1
H E Cullington, D Bele, J C Brinton, S Cooper, M Daft, J Harding, N Hatton, J Humphries, M E Lutman, J Maddocks, J Maggs, K Millward, G O'Donoghue, S Patel, K Rajput, V Salmon, T Sear, A Speers, A Wheeler, K Wilson
OBJECTIVES: This fourteen-centre project used professional rating scales and parent questionnaires to assess longitudinal outcomes in a large non-selected population of children receiving simultaneous and sequential bilateral cochlear implants. METHODS: This was an observational non-randomized service evaluation. Data were collected at four time points: before bilateral cochlear implants or before the sequential implant, one year, two years, and three years after...
January 18, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28097603/comprehensive-preclinical-evaluation-of-a-multi-physics-model-of-liver-tumor-radiofrequency-ablation
#2
Chloé Audigier, Tommaso Mansi, Hervé Delingette, Saikiran Rapaka, Tiziano Passerini, Viorel Mihalef, Marie-Pierre Jolly, Raoul Pop, Michele Diana, Luc Soler, Ali Kamen, Dorin Comaniciu, Nicholas Ayache
PURPOSE: We aim at developing a framework for the validation of a subject-specific multi-physics model of liver tumor radiofrequency ablation (RFA). METHODS: The RFA computation becomes subject specific after several levels of personalization: geometrical and biophysical (hemodynamics, heat transfer and an extended cellular necrosis model). We present a comprehensive experimental setup combining multimodal, pre- and postoperative anatomical and functional images, as well as the interventional monitoring of intra-operative signals: the temperature and delivered power...
January 17, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28094868/biomaterials-a-potential-pathway-to-healing-chronic-wounds
#3
Mara A Pop, Benjamin D Almquist
Chronic dermal wounds are a devastating problem that disproportionally affect individuals with conditions such as diabetes, paralysis, or simply old age. These wounds are extremely challenging to treat due to a heterogeneous combination of causative factors, creating a substantial burden on healthcare systems worldwide. Despite their large impact, there is currently a startling lack of options for effectively treating the underlying biological changes that occur within the wounds. Biomaterials possess an enticing ability to provide new comprehensive approaches to healing these devastating wounds; advanced wound dressings are now being developed that enable the ability to coordinate temporal delivery of multiple therapeutics, protect sensitive biologics from degradation, and provide supportive matrices that encourage the growth of tissue...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28093645/erratum-to-urinary-angiotensin-converting-enzyme-2-is-strongly-related-to-urinary-nephrin-in-type-2-diabetes-patients
#4
Mariana Ciorba Pop, Alina Ramona Potra, Cosmina Ioana Bondor, Diana Moldovan, Crina Claudia Rusu, Dan Stefan Vladutiu, Ina Maria Kacso
No abstract text is available yet for this article.
January 16, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28093218/-the-effect-of-different-genres-of-music-on-the-stress-levels-of-kennelled-dogs
#5
A Bowman, F J Dowell, N P Evans
Classical music has been shown to reduce stress in kennelled dogs; however, rapid habituation of dogs to this form of auditory enrichment has also been demonstrated. The current study investigated the physiological and behavioural response of kennelled dogs (n=38) to medium-term (5days) auditory enrichment with five different genres of music including Soft Rock, Motown, Pop, Reggae and Classical, to determine whether increasing the variety of auditory stimulation reduces the level of habituation to auditory enrichment...
January 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28091710/role-of-concurrent-vaginal-hysterectomy-in-the-outcomes-of-mesh-based-vaginal-pelvic-organ-prolapse-surgery
#6
James C Forde, Bilal Chughtai, Jennifer T Anger, Jialin Mao, Art Sedrakyan
INTRODUCTION AND HYPOTHESIS: Hysterectomy is often performed at the time of pelvic organ prolapse (POP) surgery; yet, there is insufficient evidence regarding the specific effect of hysterectomy on outcomes. We sought to determine the outcomes and associated short-term complications of mesh-based POP surgery with and without concurrent hysterectomy. METHODS: We utilized the New York Statewide Planning and Research Cooperation System (SPARCS) database to identify patients under 55 years of age undergoing surgeries for POP with mesh between 2009 and 2014...
January 13, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28091661/biochemical-characterization-of-the-selenoproteome-in-gallus-gallus-via-bioinformatics-analysis-structure-function-relationships-and-interactions-of-binding-molecules
#7
Shi-Yong Zhu, Xue-Nan Li, Xiao-Chen Sun, Jia Lin, Wei Li, Cong Zhang, Jin-Long Li
Knowledge about mammalian selenoproteins is increasing. However, the selenoproteome of birds remains considerably less understood, especially concerning its biochemical characterization, structure-function relationships and the interactions of binding molecules. In this work, the SECIS elements, subcellular localization, protein domains and interactions of binding molecules of the selenoproteome in Gallus gallus were analyzed using bioinformatics tools. We carried out comprehensive analyses of the structure-function relationships and interactions of the binding molecules of selenoproteins, to provide biochemical characterization of the selenoproteome in Gallus gallus...
January 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28089717/persistent-organic-pollutants-pops-in-human-follicular-fluid-and-in-vitro-fertilization-outcomes-a-pilot-study
#8
Michael S Bloom, Victor Y Fujimoto, Robin Storm, Li Zhang, Celeste D Butts, Diana Sollohub, Robert L Jansing
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF)...
January 9, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28089209/assessment-of-seasonal-variations-in-persistent-organic-pollutants-across-the-region-of-tuscany-using-passive-air-samplers
#9
Victor H Estellano, Karla Pozo, Petra Přibylová, Jana Klánová, Ondřej Audy, Silvano Focardi
Concentrations of persistent organic pollutants (POPs) were measured for an entire year in the region of Tuscany, Italy. Passive air samplers consisting of polyurethane foam (PUF) disks were deployed over four sampling periods of 3-5 months from April 2008 to July 2009 in urban (n = 6) and rural (n = 4) sites. The aim of the study was to characterize the spatial and seasonal variations in selected POPs. The POP concentrations (pg m(-3)) in the air were dominated by dichlorodiphenyltrichloroethane and metabolites (DDTs) and polychlorinated biphenyls (∑7PCBs)...
January 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28087412/pain-prediction-by-serum-biomarkers-of-bone-turnover-in-people-with-knee-osteoarthritis-an-observational-study-of-tracp5b-and-cathepsin-k-in-oa
#10
Lilian N Nwosu, Maximilian Allen, Laura Wyatt, Janet L Huebner, Victoria Chapman, David A Walsh, Virginia B Kraus
OBJECTIVES: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). METHODS: Sera and clinical data were collected from 129 people (97 with 3-year follow-up) with knee OA from the Prediction of Osteoarthritis Progression (POP) cohort. Knee OA-related outcomes in POP included: WOMAC pain, NHANES I (pain, aching and stiffness), subchondral sclerosis, and radiographically determined tibiofemoral and patellofemoral OA...
January 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28079124/axisymmetric-rotational-stagnation-point-flow-impinging-radially-a-permeable-stretching-shrinking-surface-in-a-nanofluid-using-tiwari-and-das-model
#11
Natalia C Roşca, Ioan Pop
In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078670/levator-ani-muscle-avulsion-is-a-risk-factor-for-vaginal-pessary-expulsion-within-1-year-for-pelvic-organ-prolapse
#12
Rachel Yau Kar Cheung, Jacqueline Ho Sze Lee, Lai Loi Lee, Tony Kwok Hung Chung, Symphorosa Shing Chee Chan
OBJECTIVE: The aim of this study was to investigate whether presence of levator ani muscle (LAM) avulsion was associated with expulsion of vaginal pessary for women with pelvic organ prolapse (POP). METHODS: This prospective observational study recruited consecutive women with symptomatic POP. Vaginal pessary was offered and offline analysis of the 3D/4D transperineal ultrasound volume data of women was performed. Volume acquisition had been performed before pessary insertion...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28073797/physical-and-cultural-determinants-of-postpartum-pelvic-floor-support-and-symptoms-following-vaginal-delivery-a-protocol-for-a-mixed-methods-prospective-cohort-study
#13
Ingrid E Nygaard, Erin Clark, Lauren Clark, Marlene J Egger, Robert Hitchcock, Yvonne Hsu, Peggy Norton, Ana Sanchez-Birkhead, Janet Shaw, Xiaoming Sheng, Michael Varner
INTRODUCTION: Pelvic floor disorders (PFDs), including pelvic organ prolapse (POP), stress and urgency urinary incontinence, and faecal incontinence, are common and arise from loss of pelvic support. Although severe disease often does not occur until women become older, pregnancy and childbirth are major risk factors for PFDs, especially POP. We understand little about modifiable factors that impact pelvic floor function recovery after vaginal birth. This National Institutes of Health (NIH)-funded Program Project, 'Bridging physical and cultural determinants of postpartum pelvic floor support and symptoms following vaginal delivery', uses mixed-methods research to study the influences of intra-abdominal pressure, physical activity, body habitus and muscle fitness on pelvic floor support and symptoms as well as the cultural context in which women experience those changes...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28070831/the-prolyl-oligopeptidase-inhibitor-suam-14746-attenuates-the-proliferation-of-human-breast-cancer-cell-lines-in-vitro
#14
Satoshi Tanaka, Kanayo Suzuki, Minoru Sakaguchi
BACKGROUND: Prolyl oligopeptidase (POP, EC 3.4.1.26) is a serine peptidase that hydrolyzes post-proline peptide bonds in peptides that are <30 amino acids in length. We previously reported that POP inhibition suppressed the growth of NB-1 human neuroblastomas cells and KATO III human gastric cancer cells. POP activity is commonly elevated in many cancers, which includes breast cancer. However, the effect of POP inhibition as a candidate breast cancer therapy is unknown. METHODS: The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression)...
January 9, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28070080/%C3%AE-melt-structure-of-1-3-dipalmitoyl-2-oleoyl-sn-glycerol-pop-under-a-thermal-thawing-process-studied-by-infrared-spectroscopy
#15
Hiroharu Yui, Yuuki Isozaki, Toshinori Morisaku
The temperature thawing, as called tempering, of triacylglycerols (TAGs) is an important processing method in food productions, such as chocolates, cream, confections, and spreads. Especially, melt-mediation by temperature thawing is famous in chocolate production for controlling the polymorphic crystalline forms and accelerating crystallization. In the present study, we investigated the α-melt structure of 1,3-dipalmitoyl-2-oleoyl-sn-glycerol (POP), one of the major continuants of cacao butter, under a phase transition from its melt to γ-crystal with in-situ attenuated total reflection-infrared (ATR-IR) spectroscopy...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28068065/sustained-nitric-oxide-release-from-a-tertiary-s-nitrosothiol-based-polyphosphazene-coating
#16
Alec Lutzke, Jesus B Tapia, Megan J Neufeld, Melissa M Reynolds
Nitric oxide (NO) occurs naturally in mammalian biochemistry as a critical signaling molecule and exhibits antithrombotic, antibacterial, and wound-healing properties. NO-forming biodegradable polymers have been utilized in the development of antithrombotic or antibacterial materials for biointerfacial applications, including tissue engineering and the fabrication of erodible coatings for medical devices such as stents. Use of such NO-forming polymers has frequently been constrained by short-term release or limited NO storage capacity and has led to the pursuit of new materials with improved NO release function...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28067747/readmission-and-reoperation-after-surgery-for-pelvic-organ-prolapse
#17
Erik D Hokenstad, Amy E Glasgow, Elizabeth B Habermann, John A Occhino
OBJECTIVES: We aimed to determine the rates of readmission and reoperation for patients undergoing surgery for pelvic organ prolapse (POP). METHODS: The American College of Surgeons National Surgical Quality Improvement Program Participant User File was used to select all surgeries performed for POP from 2012 through 2014. The cohort was then reviewed for unplanned readmissions and unplanned reoperations within 30 days of POP surgery. Patient and procedural factors associated with readmission or reoperation were compared using χ analyses and Student t test...
January 6, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28063657/persistent-organic-pollutants-pops-in-the-atmosphere-of-three-chilean-cities-using-passive-air-samplers
#18
Karla Pozo, Germán Oyola, Victor H Estellano, Tom Harner, Anny Rudolph, Petra Prybilova, Petr Kukucka, Ondrej Audi, Jana Klánová, America Metzdorff, Silvano Focardi
In this study passive air samplers containing polyurethane foam (PUF) disks were deployed in three cities across Chile; Santiago (STG) (n=5, sampling sites), Concepciόn (CON) (n=6) and Temuco (TEM) (n=6) from 2008 to 2009. Polychlorinated biphenyls (PCBs) (7 indicator congeners), chlorinated pesticides hexachlorocyclohexanes (HCHs), dichlorodiphenyl trichloroethanes (DDTs) and flame retardants such as polybrominated diphenyl ethers (PBDEs) were determined by gas chromatography coupled mass spectrometry (GC/MS)...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28062904/turkish-adaptation-of-the-pelvic-organ-prolapse-symptom-score-and-its-validity-and-reliability
#19
Nuriye Özengin, Serap Kaya, Ceren Orhan, Yeşim Bakar, Bülent Duran, Handan Ankaralı, Türkan Akbayrak
INTRODUCTION AND HYPOTHESIS: The purpose of this study was to adapt the Pelvic Organ Prolapse Symptom Score (POP-SS) into Turkish and evaluate its reliability and validity. METHODS: The POP-SS was adapted into Turkish by following the steps of the intercultural adaptation process. One hundred and three women with symptomatic or asymptomatic pelvic organ prolapse (POP) completed the Turkish POP-SS and other valid and reliable Turkish tools for POP: Pelvic Organ Prolapse Distress Inventory 6 (POPDI-6), Colorectal-Anal Distress Inventory 8 (CRADI-8), Urinary Distress Inventory 6 (UDI-6), Pelvic Floor Distress Inventory 20 (PFDI-20), and Pelvic Organ Prolapse Impact Questionnaire 7 (POPIQ-7)...
January 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28061853/location-location-location-environmental-factors-better-predict-malaria-positive-individuals-during-reactive-case-detection-than-index-case-demographics-in-southern-province-zambia
#20
David A Larsen, Tokozile Ngwenya-Kangombe, Sanford Cheelo, Busiku Hamainza, John Miller, Anna Winters, Daniel J Bridges
BACKGROUND: Decreasing malaria transmission leads to increasing heterogeneity with increased risk in both hot spots (locations) and hot pops (certain demographics). In Southern Province, Zambia, reactive case detection has formed a part of malaria surveillance and elimination efforts since 2011. Various factors may be associated with finding malaria infections during case investigations, including the demographics of the incident case and environmental characteristics of the location of the incident case...
January 6, 2017: Malaria Journal
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