keyword
MENU ▼
Read by QxMD icon Read
search

mot

keyword
https://www.readbyqxmd.com/read/29021584/mortalin-deficiency-suppresses-fibrosis-and-induces-apoptosis-in-keloid-spheroids
#1
Won Jai Lee, Hyo Min Ahn, Youjin Na, Renu Wadhwa, JinWoo Hong, Chae-Ok Yun
Mortalin (Mot) is a mitochondrial chaperone of the heat shock protein 70 family and it's pro-proliferative and anti-apoptosis functions could be associated with keloid pathogenesis, and blocking of mortalin and its interaction with p53 might be a potential novel target for the treatment of keloid. Therefore, we generated mortalin-specific small hairpin (sh) RNAs (dE1-RGD/GFP/shMot) and introduced into keloid spheroids for examination of its apoptotic and anti-fibrotic effect. On keloid tissues, mortalin expression was higher than adjacent normal tissues and it's protein expressions were activated keloid fibroblasts (KFs)...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29016693/driving-simulator-scenarios-and-measures-to-faithfully-evaluate-risky-driving-behavior-a-comparative-study-of-different-driver-age-groups
#2
COMPARATIVE STUDY
Jesse Michaels, Romain Chaumillon, David Nguyen-Tri, Donald Watanabe, Pierro Hirsch, Francois Bellavance, Guillaume Giraudet, Delphine Bernardin, Jocelyn Faubert
To investigate the links between mental workload, age and risky driving, a cross-sectional study was conducted on a driving simulator using several established and some novel measures of driving ability and scenarios of varying complexity. A sample of 115 drivers was divided into three age and experience groups: young inexperienced (18-21 years old), adult experienced (25-55 years old) and older adult (70-86 years old). Participants were tested on three different scenarios varying in mental workload from low to high...
2017: PloS One
https://www.readbyqxmd.com/read/28994791/subcellular-fractionation-for-erk-activation-upon-mitochondrial-derived-peptide-treatment
#3
Su-Jeong Kim, Jialin Xiao, Pinchas Cohen, Kelvin Yen
Mitochondrial-derived peptides (MDPs) are a new class of peptides that are encoded by small open reading frames within other known genes of the mitochondrial genome. MDPs have a wide variety of biological effects such as protecting neurons from apoptosis, improving metabolic markers, and protecting cells from chemotherapy. Humanin was the first MDP to be discovered and is the most studied peptide among the MDP family. The membrane receptors and downstream signaling pathways of humanin have been carefully characterized...
September 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28949175/radio-frequency-magneto-optical-trapping-of-caf-with-high-density
#4
Loïc Anderegg, Benjamin L Augenbraun, Eunmi Chae, Boerge Hemmerling, Nicholas R Hutzler, Aakash Ravi, Alejandra Collopy, Jun Ye, Wolfgang Ketterle, John M Doyle
We demonstrate significantly improved magneto-optical trapping of molecules using a very slow cryogenic beam source and either rf modulated or dc magnetic fields. The rf magneto-optical trap (MOT) confines 1.0(3)×10^{5} CaF molecules at a density of 7(3)×10^{6}  cm^{-3}, which is an order of magnitude greater than previous molecular MOTs. Near Doppler-limited temperatures of 340(20)  μK are attained. The achieved density enables future work to directly load optical tweezers and create optical arrays for quantum simulation...
September 8, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28935058/n-o-349-consommation-de-substances-psychoactives-pendant-la-grossesse
#5
Alice Ordean, Suzanne Wong, Lisa Graves
OBJECTIFS: Accroître la sensibilisation à la consommation problématique de substances psychoactives pendant la grossesse et les connaissances à ce sujet, et formuler des recommandations factuelles relatives à la prise en charge de cet épineux problème clinique à l'intention de l'ensemble des fournisseurs de soins. OPTIONS: La présente directive clinique analyse l'utilisation d'outils de dépistage, l'approche générale de soins et les recommandations pour la prise en charge clinique de la consommation problématique de substances psychoactives pendant la grossesse...
October 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28914932/observation-of-7pp23-2%C3%A2-7dd2-optical-transitions-in-209-and-210-francium-isotopes
#6
S Agustsson, G Bianchi, R Calabrese, L Corradi, A Dainelli, A Khanbekyan, C Marinelli, E Mariotti, L Marmugi, G Mazzocca, L Moi, L Ricci, L Stiaccini, L Tomassetti
We report on the direct experimental observation of the 7pP23/2→7dD2 optical transitions in 209 and 210 francium isotopes. By continuously monitoring the fluorescence emitted by the isotopes collected in a magneto-optical trap (MOT), the electric dipole transitions 7pP23/2→7dD25/2 of Fr209, not yet experimentally observed, and 7pP23/2→7dD25/2, 7pP23/2→7dD25/2 of Fr210 were detected as sub-Doppler depletion dips of the cold atom population. This approach allowed unambiguous identification of the excited state hyperfine structures, even in the absence of a large stable vapor...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28891229/effect-of-different-mini-volume-colloid-centrifugation-configurations-on-flow-cytometrically-sorted-sperm-recovery-efficiency-and-quality-using-a-computer-assisted-semen-analyzer
#7
L B Ferré, J L Chitwood, C Fresno, H H Ortega, M E Kjelland, P J Ross
Straws of sex-sorted sperm are usually packaged at a low concentration (e.g., ~2.1 × 10(6)  sperm/ml) and cost significantly more than unsorted conventional semen from the same sire. In order to maximize the efficiency of using sex-sorted sperm under in vitro fertilization conditions, the selection of an appropriate sperm separation technique is essential. In this study, the effect of using different silane-coated silica colloid dilutions and layering configurations during centrifugation of sex-sorted sperm was examined over an extended period of incubation time...
September 11, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28865297/effects-of-hcg-and-salmon-gonadoliberine-analogue-on-spermiation-in-the-eurasian-perch-perca-fluviatilis
#8
Daniel Żarski, Gergely Bernáth, Jarosław Król, Beata I Cejko, Zoltán Bokor, Katarzyna Palińska-Żarska, Sylvain Milla, Pascal Fontaine, Sławomir Krejszeff
This study analysed (i) the effect of human chorionic gonadotropin (hCG) and salmon gonadoliberine analogue (sGnRHa) on the effectiveness of induction of spermiation and (ii) the effect of latency time following the application of those spawning agents on the quantity and quality of the sperm of Eurasian perch, Perca fluviatilis, obtained during out-of-season spawning. For this study, pond-reared fish were used which had been acclimated to the controlled conditions. Three groups were distinguished which were treated with either saline (0...
August 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/28818362/two-year-follow-up-of-crohn-s-patients-substituted-to-certolizumab-anti-tnfa-therapy-savant-2
#9
Andrew Motlis, Moheb Boktor, Paul Jordan, Urska Cvek, Marjan Trutschl, J Steven Alexander
The effectiveness of ant-TNF 'biologic' therapy in is well supported in the management of moderate to severe Crohn's Disease (CD). Our first 'SAVANT' study was to our knowledge the first study report one- year outcomes in patients (n=60) who switched from previous anti-TNFa treatment to Cimzia/Certolizumab. This current study (SAVANT 2) follows up on longer term outcomes and provides additional clinical and biochemical data that may contribute to therapeutic responses. This IRB approved study was a retrospective analysis of the initial patients included in SAVANT 1...
August 9, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28783726/proteins-evolve-on-the-edge-of-supramolecular-self-assembly
#10
Hector Garcia-Seisdedos, Charly Empereur-Mot, Nadav Elad, Emmanuel D Levy
The self-association of proteins into symmetric complexes is ubiquitous in all kingdoms of life. Symmetric complexes possess unique geometric and functional properties, but their internal symmetry can pose a risk. In sickle-cell disease, the symmetry of haemoglobin exacerbates the effect of a mutation, triggering assembly into harmful fibrils. Here we examine the universality of this mechanism and its relation to protein structure geometry. We introduced point mutations solely designed to increase surface hydrophobicity among 12 distinct symmetric complexes from Escherichia coli...
August 10, 2017: Nature
https://www.readbyqxmd.com/read/28767740/cryopreservation-of-waigieu-seaperch-psammoperca-waigiensis-sperm
#11
M H Le
BACKGROUND: The cryopreservation protocols have been applied for sperm prevervation of many fish species, but have not been developed for Waigieu seaperch Psammoperca waigiensis, an important aquaculture species in Vietnam. OBJECTIVE: The objectives of this study were to find the best cryoprotectant, extender, freezing method and dilution ratio for sperm cryopreservation of Waigieu seaperch. MATERIALS AND METHODS: An effective protocol was established by comparing different cryodiluents created by mixing various cryoprotectants and extenders...
May 2017: Cryo Letters
https://www.readbyqxmd.com/read/28729105/n-o-223-tenue-syst%C3%A3-matique-d%C3%A2-un-examen-%C3%A3-chographique-obst%C3%A3-trical-au-cours-du-deuxi%C3%A3-me-trimestre-contenu-d%C3%A2-un-examen-et-d%C3%A2-un-rapport-exhaustifs
#12
Yvonne Cargill, Lucie Morin
OBJECTIF: Analyser les avantages d'un examen échographique exhaustif au cours du deuxième trimestre et les conditions nécessaires à sa tenue, ainsi que la documentation requise. ISSUES: Un examen échographique exhaustif au cours du deuxième trimestre offre des renseignements au sujet du nombre de fœtus, de l'âge gestationnel, de l'emplacement du placenta et de l'anatomie fœtale et maternelle. RéSULTATS: Dans le cadre de la rédaction du présent document, le document « Practice Guideline for the Performance of Obstetric Ultrasound Examinations » du American Institute of Ultrasound in Medicine, le bulletin de pratique « Ultrasound in Pregnancy » du American College of Obstetricians and Gynaecologists et le rapport de groupe de travail « Ultrasound Screening » du Royal College of Obstetricians and Gynaecologists ont été analysés...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28671755/discriminating-agonist-from-antagonist-ligands-of-the-nuclear-receptors-using-different-chemoinformatics-approaches
#13
Nathalie Lagarde, Solenne Delahaye, Aurore Jérémie, Nesrine Ben Nasr, Hélène Guillemain, Charly Empereur-Mot, Vincent Laville, Taoufik Labib, Manon Réau, Florent Langenfeld, Jean-François Zagury, Matthieu Montes
Nuclear receptors (NRs) constitute an important class of therapeutic targets. During the last 4 years, we tackled the pharmacological profile assessment of NR ligands for which we constructed the NRLiSt BDB. We evaluated and compared the performance of different virtual screening approaches: mean of molecular descriptor distribution values, molecular docking and 3D pharmacophore models. The simple comparison of the distribution profiles of 4885 molecular descriptors between the agonist and antagonist datasets didn't provide satisfying results...
July 3, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28669422/slower-resting-alpha-frequency-is-associated-with-superior-localisation-of-moving-targets
#14
Christina J Howard, Craig P A Arnold, Matthew K Belmonte
We examined the neurophysiological underpinnings of individual differences in the ability to maintain up-to-date representations of the positions of moving objects. In two experiments similar to the multiple object tracking (MOT) task, we asked observers to monitor continuously one or several targets as they moved unpredictably for a semi-random period. After all objects disappeared, observers were immediately prompted to report the perceived final position of one queried target. Precision of these position reports declined with attentional load, and reports tended to best resemble positions occupied by the queried target between 0 and 30ms in the past...
October 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28622556/early-chemical-and-ecotoxicological-responses-of-the-varano-lagoon-se-italy-to-a-flood-event
#15
Adele Fabbrocini, Daniele Cassin, Angela Santucci, Tommaso Scirocco, Antonietta Specchiulli, Raffaele D'Adamo
The effects on coastal lagoons of floods resulting from intense rainfall need to be assessed using a multidisciplinary approach, able to describe in real time the occurrence of changes in sediment quality, anticipating risk situations. In the present study the effectiveness as pre-screening tool of the MOT-test, an innovative bioassay that uses sperm motility as endpoint, has been evaluated; its response has been compared with the sediment chemical characterization, in order to determine the effects of a flood event occurred in the Varano lagoon, a poorly anthropized Mediterranean coastal lagoon...
June 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28600676/the-contributions-of-visual-and-central-attention-to-visual-working-memory
#16
Alessandra S Souza, Klaus Oberauer
We investigated the role of two kinds of attention-visual and central attention-for the maintenance of visual representations in working memory (WM). In Experiment 1 we directed attention to individual items in WM by presenting cues during the retention interval of a continuous delayed-estimation task, and instructing participants to think of the cued items. Attending to items improved recall commensurate with the frequency with which items were attended (0, 1, or 2 times). Experiments 1 and 3 further tested which kind of attention-visual or central-was involved in WM maintenance...
June 9, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28586771/can-in-bag-manual-morcellation-represent-an-alternative-to-uncontained-power-morcellation-in-laparoscopic-myomectomy-a-randomized-controlled-trial
#17
Clarissa Frascà, Eugenia Degli Esposti, Alessandro Arena, Gianmarco Tuzzato, Elisa Moro, Valentina Martelli, Renato Seracchioli
AIMS: The study aimed to evaluate feasibility and safety of in-bag manual morcellation compared to uncontained power morcellation during laparoscopic myomectomy. METHODS: A total of 72 women undergoing laparoscopic myomectomy were randomized into 2 treatment groups: 34 patients underwent in-bag manual morcellation (experimental group) and 38 were submitted to uncontained power morcellation (control group). The primary end point was the comparison of morcellation operative time (MOT)...
June 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28574175/mitochondrially-derived-peptides-as-novel-regulators-of-metabolism
#18
Su-Jeong Kim, Jialin Xiao, Junxiang Wan, Pinchas Cohen, Kelvin Yen
Mitochondrially derived peptides represent a new class of circulating signalling molecules. Humanin, the first member of this class, has been shown to have several metabolic effects such as reducing weight gain and visceral fat and increasing glucose-stimulated insulin release. The discovery of several other new members, such as MOTS-c and SHLP1-6, has further added to this group. These new peptides have also been found to affect metabolism with MOTS-c potently decreasing weight gain in mice on a high-fat diet...
June 2, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28569539/distracting-tracking-interactions-between-negative-emotion-and-attentional-load-in-multiple-object-tracking
#19
Gina M D'Andrea-Penna, Sebastian M Frank, Todd F Heatherton, Peter U Tse
Stimuli that attract exogenous attention have been shown to interfere with behavioral performance on various tasks. In the present study, participants performed multiple-object tracking (MOT) in conditions where either neutral or negatively valenced images were flashed at fixation. Results reveal a significant impairment of tracking accuracy in the emotional MOT conditions compared to the neutral conditions specifically at the highest level of task difficulty. These findings suggest that emotional distraction is most detrimental when maximal endogenous attentional engagement is required...
September 2017: Emotion
https://www.readbyqxmd.com/read/28559020/establishment-and-characterization-of-a-clear-cell-odontogenic-carcinoma-cell-line-with-ewsr1-atf1-fusion-gene
#20
Satoko Kujiraoka, Takaaki Tsunematsu, Yukiko Sato, Maki Yoshida, Ayataka Ishikawa, Rei Tohyama, Michio Tanaka, Yutaka Kobayashi, Tomoyuki Kondo, Aya Ushio, Kunihiro Otsuka, Mie Kurosawa, Masako Saito, Akiko Yamada, Rieko Arakaki, Hirokazu Nagai, Hiromasa Nikai, Kengo Takeuchi, Toshitaka Nagao, Youji Miyamoto, Naozumi Ishimaru, Yasusei Kudo
OBJECTIVE: Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and characterized this cell line. MATERIALS AND METHODS: To detect the EWSR1-ATF1 fusion gene, we used three CCOC cases, including the present case, by RT-PCR and FISH analysis...
June 2017: Oral Oncology
keyword
keyword
38489
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"