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https://www.readbyqxmd.com/read/28671755/discriminating-agonist-from-antagonist-ligands-of-the-nuclear-receptors-using-different-chemoinformatics-approaches
#1
Nathalie Lagarde, Solenne Delahaye, Aurore Jérémie, Nesrine Ben Nasr, Hélène Guillemain, Charly Empereur-Mot, Vincent Laville, Taoufik Labib, Manon Réau, Florent Langenfeld, Jean-François Zagury, Matthieu Montes
Nuclear receptors (NRs) constitute an important class of therapeutic targets. During the last 4 years, we tackled the pharmacological profile assessment of NR ligands for which we constructed the NRLiSt BDB. We evaluated and compared the performance of different virtual screening approaches: mean of molecular descriptor distribution values, molecular docking and 3D pharmacophore models. The simple comparison of the distribution profiles of 4885 molecular descriptors between the agonist and antagonist datasets didn't provide satisfying results...
July 3, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28669422/slower-resting-alpha-frequency-is-associated-with-superior-localisation-of-moving-targets
#2
Christina J Howard, Craig P A Arnold, Matthew K Belmonte
We examined the neurophysiological underpinnings of individual differences in the ability to maintain up-to-date representations of the positions of moving objects. In two experiments similar to the multiple object tracking (MOT) task, we asked observers to monitor continuously one or several targets as they moved unpredictably for a semi-random period. After all objects disappeared, observers were immediately prompted to report the perceived final position of one queried target. Precision of these position reports declined with attentional load, and reports tended to best resemble positions occupied by the queried target between 0 and 30ms in the past...
June 29, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28622556/early-chemical-and-ecotoxicological-responses-of-the-varano-lagoon-se-italy-to-a-flood-event
#3
Adele Fabbrocini, Daniele Cassin, Angela Santucci, Tommaso Scirocco, Antonietta Specchiulli, Raffaele D'Adamo
The effects on coastal lagoons of floods resulting from intense rainfall need to be assessed using a multidisciplinary approach, able to describe in real time the occurrence of changes in sediment quality, anticipating risk situations. In the present study the effectiveness as pre-screening tool of the MOT-test, an innovative bioassay that uses sperm motility as endpoint, has been evaluated; its response has been compared with the sediment chemical characterization, in order to determine the effects of a flood event occurred in the Varano lagoon, a poorly anthropized Mediterranean coastal lagoon...
June 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28600676/the-contributions-of-visual-and-central-attention-to-visual-working-memory
#4
Alessandra S Souza, Klaus Oberauer
We investigated the role of two kinds of attention-visual and central attention-for the maintenance of visual representations in working memory (WM). In Experiment 1 we directed attention to individual items in WM by presenting cues during the retention interval of a continuous delayed-estimation task, and instructing participants to think of the cued items. Attending to items improved recall commensurate with the frequency with which items were attended (0, 1, or 2 times). Experiments 1 and 3 further tested which kind of attention-visual or central-was involved in WM maintenance...
June 9, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28586771/can-in-bag-manual-morcellation-represent-an-alternative-to-uncontained-power-morcellation-in-laparoscopic-myomectomy-a-randomized-controlled-trial
#5
Clarissa Frascà, Eugenia Degli Esposti, Alessandro Arena, Gianmarco Tuzzato, Elisa Moro, Valentina Martelli, Renato Seracchioli
AIMS: The study aimed to evaluate feasibility and safety of in-bag manual morcellation compared to uncontained power morcellation during laparoscopic myomectomy. METHODS: A total of 72 women undergoing laparoscopic myomectomy were randomized into 2 treatment groups: 34 patients underwent in-bag manual morcellation (experimental group) and 38 were submitted to uncontained power morcellation (control group). The primary end point was the comparison of morcellation operative time (MOT)...
June 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28574175/mitochondrial-derived-peptides-as-novel-regulators-of-metabolism
#6
Su-Jeong Kim, Jialin Xiao, Junxiang Wan, Pinchas Cohen, Kelvin Yen
Mitochondrial derived peptides represent a new class of circulating signalling molecules. Humanin, the first member of this class, has been shown to have several metabolic effects such as reducing weight gain and visceral fat and increasing glucose stimulated insulin release. The discovery of several other new members such as MOTS-c and SHLP1-6, have further added to this group. These new peptides have also been found to affect metabolism with MOTS-c potently decreasing weight gain in mice on a high fat diet...
June 2, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28569539/distracting-tracking-interactions-between-negative-emotion-and-attentional-load-in-multiple-object-tracking
#7
Gina M D'Andrea-Penna, Sebastian M Frank, Todd F Heatherton, Peter U Tse
Stimuli that attract exogenous attention have been shown to interfere with behavioral performance on various tasks. In the present study, participants performed multiple-object tracking (MOT) in conditions where either neutral or negatively valenced images were flashed at fixation. Results reveal a significant impairment of tracking accuracy in the emotional MOT conditions compared to the neutral conditions specifically at the highest level of task difficulty. These findings suggest that emotional distraction is most detrimental when maximal endogenous attentional engagement is required...
June 1, 2017: Emotion
https://www.readbyqxmd.com/read/28559020/establishment-and-characterization-of-a-clear-cell-odontogenic-carcinoma-cell-line-with-ewsr1-atf1-fusion-gene
#8
Satoko Kujiraoka, Takaaki Tsunematsu, Yukiko Sato, Maki Yoshida, Ayataka Ishikawa, Rei Tohyama, Michio Tanaka, Yutaka Kobayashi, Tomoyuki Kondo, Aya Ushio, Kunihiro Otsuka, Mie Kurosawa, Masako Saito, Akiko Yamada, Rieko Arakaki, Hirokazu Nagai, Hiromasa Nikai, Kengo Takeuchi, Toshitaka Nagao, Youji Miyamoto, Naozumi Ishimaru, Yasusei Kudo
OBJECTIVE: Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and characterized this cell line. MATERIALS AND METHODS: To detect the EWSR1-ATF1 fusion gene, we used three CCOC cases, including the present case, by RT-PCR and FISH analysis...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28556765/erratum-bardid-et-al-2016
#9
(no author information available yet)
In the article by Bardid F., Huyben F., Deconinck F.J.A., De Martelaer K., Seghers J., & Lenoir M., "Convergent and Divergent Validity Between the KTK and MOT 4-6 Motor Tests in Early Childhood, " in Adapted Pyhsical Activity Quarterly, 33(1), the wrong DOI was printed. The DOI for this article is http://dx.doi.org/10.1123/APAQ.2014-0228. The online version has been corrected.
April 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28549562/n-o-346-%C3%A3-ge-g%C3%A3-n%C3%A3-sique-avanc%C3%A3-et-fertilit%C3%A3
#10
Kimberly E Liu, Allison Case
OBJECTIFS: Sensibiliser la population à la baisse naturelle de la fertilité avec l'âge, chez les femmes et les hommes, et à l'égard de la reproduction naturelle et des technologies de procréation assistée (TPA); formuler des recommandations de prise en charge; et analyser les méthodes d'évaluation du vieillissement ovarien. OPTIONS: La présente directive clinique passe en revue les options offertes pour l'évaluation de la réserve ovarienne et pour le traitement de l'infertilité faisant appel aux TPA chez les femmes d'âge génésique avancé infertiles...
May 23, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28495200/genotyping-of-theileria-lestoquardi-from-sheep-and-goats-in-sudan-to-support-control-of-malignant-ovine-theileriosis
#11
A M Ali, D A Salih, M N Njahira, S K Hassan, A M El Hussein, Z Liu, H Yin, R Pelle, R A Skilton
Theileriosis, caused by parasitic protozoa of the genus Theileria parasites, are among the major tick-borne diseases of ruminant livestock. The largest economic losses are attributed in particular to those caused by the leukoproliferative species of Theileria: T. parva, T. annulata and T. lestoquardi. Theileria lestoquardi is transmitted by Hyalomma ticks and causes malignant ovine theileriosis (MOT), a disease that is particularly prevalent in Sudan. The disease is considered of a high economic importance in Sudan, where export of sheep is a major component of the national economy...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28493319/an-elitist-multiobjective-tabu-search-for-optimal-design-of-groundwater-remediation-systems
#12
Yun Yang, Jianfeng Wu, Jinguo Wang, Zhifang Zhou
This study presents a new multiobjective evolutionary algorithm (MOEA), the elitist multiobjective tabu search (EMOTS), and incorporates it with MODFLOW/MT3DMS to develop a groundwater simulation-optimization (SO) framework based on modular design for optimal design of groundwater remediation systems using pump-and-treat (PAT) technique. The most notable improvement of EMOTS over the original multiple objective tabu search (MOTS) lies in the elitist strategy, selection strategy, and neighborhood move rule. The elitist strategy is to maintain all nondominated solutions within later search process for better converging to the true Pareto front...
May 10, 2017: Ground Water
https://www.readbyqxmd.com/read/28471736/cognitive-motor-dual-task-ability-of-athletes-with-and-without-intellectual-impairment
#13
Debbie Van Biesen, Lore Jacobs, Katina McCulloch, Luc Janssens, Yves C Vanlandewijck
Cognition is important in many sports, for example, making split-second-decisions under pressure, or memorising complex movement sequences. The dual-task (DT) paradigm is an ecologically valid approach for the assessment of cognitive function in conjunction with motor demands. This study aimed to determine the impact of impaired intelligence on DT performance. The motor task required balancing on one leg on a beam, and the cognitive task was a multiple-object-tracking (MOT) task assessing dynamic visual-search capacity...
May 4, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28463274/theoretical-design-for-generation-of-slow-light-in-a-two-dimensional-magneto-optical-trap-using-electromagnetically-induced-transparency
#14
Sumit Bhushan, Raghavan K Easwaran
In this paper, we propose a novel technique for slow light experiments using electromagnetically induced transparency using a two-dimensional magneto optical trap (2D-MOT). A compact 2D-MOT design efficient for quantum memory applications with adjustable optical depth (OD) is proposed. We estimated the OD for our 2D-MOT setup and found that light group velocities as low as 1.4 m/s can be attained. Our design for 2D-MOT allows precise control and optimization of the OD such that high storage efficiencies could also be achieved...
May 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28459508/effect-of-electric-acupoint-stimulation-on-gastrointestinal-hormones-and-motility-among-geriatric-postoperative-patients-with-gastrointestinal-tumors
#15
RANDOMIZED CONTROLLED TRIAL
Lili Hou, Lei Xu, Yan Shi, Fen Gu
OBJECTIVE: To evaluate the effects of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors, and to explore an efficient and noninvasive method for postoperative recovery of bowel functions. METHODS: Forty patients were randomly and evenly assigned into a regular nursing care group (RNC) and an acupoint electric stimulation group (AES). Patients in the RNC group received regular nursing care and patients in the AES group received regular nursing care plus electric stimulation of acupoints...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/28458145/chlorite-reactivity-with-myoglobin-analogy-with-peroxide-and-nitrite-chemistry
#16
Cristina Bischin, Augustin Mot, Andrei Stefancu, Nicolae Leopold, Denisa Hathazi, Grigore Damian, Radu Silaghi-Dumitrescu
Stopped-flow UV-vis data allow for the first time direct spectroscopic detection of a ferryl species during the reaction of met myoglobin (Mb) with chlorite, analogous to what is observed in the reaction with peroxides. Ferryl is also observed in the reaction of oxy Mb+chlorite. A pathway involving Fe-O-O-ClO2 is explored by analogy with the Fe-O-O-NO and Fe-O-O-NO2 previously proposed as intermediates in the reactions of oxy globins with nitric oxide and nitrite, respectively. However, Fe-O-O-ClO2 is not detectable in these stopped-flow experiments and is in fact, unlike its nitrogenous congeners, predicted by density functional theory (DFT) to be impossible for a heme complex...
April 23, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28454895/sustained-attention-to-objects-motion-sharpens-position-representations-attention-to-changing-position-and-attention-to-motion-are-distinct
#17
Christina J Howard, Victoria Rollings, Amy Hardie
In tasks where people monitor moving objects, such the multiple object tracking task (MOT), observers attempt to keep track of targets as they move amongst distracters. The literature is mixed as to whether observers make use of motion information to facilitate performance. We sought to address this by two means: first by superimposing arrows on objects which varied in their informativeness about motion direction and second by asking observers to attend to motion direction. Using a position monitoring task, we calculated mean error magnitudes as a measure of the precision with which target positions are represented...
May 4, 2017: Vision Research
https://www.readbyqxmd.com/read/28448037/cooling-an-optically-trapped-ultracold-fermi-gas-by-periodical-driving
#18
Jiaming Li, Leonardo F de Melo, Le Luo
We present a cooling method for a cold Fermi gas by parametrically driving atomic motions in a crossed-beam optical dipole trap (ODT). Our method employs the anharmonicity of the ODT, in which the hotter atoms at the edge of the trap feel the anharmonic components of the trapping potential, while the colder atoms in the center of the trap feel the harmonic one. By modulating the trap depth with frequencies that are resonant with the anharmonic components, we selectively excite the hotter atoms out of the trap while keeping the colder atoms in the trap, generating parametric cooling...
March 30, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28431864/toward-an-integrative-and-predictive-sperm-quality-analysis-in-bos-taurus
#19
J L Yániz, C Soler, C Alquézar-Baeta, P Santolaria
There is a need to develop more integrative sperm quality analysis methods, enabling researchers to evaluate different parameters simultaneously cell by cell. In this work, we present a new multi-parametric fluorescent test able to discriminate different sperm subpopulations based on their labeling pattern and motility characteristics. Cryopreserved semen samples from 20 Holstein bulls were used in the study. Analyses of sperm motility using computer-assisted sperm analysis (CASA-mot), membrane integrity by acridine orange-propidium iodide combination and multi-parametric by the ISAS(®)3Fun kit, were performed...
March 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28428259/rabl2-interacts-with-the-intraflagellar-transport-b-complex-and-cep19-and-participates-in-ciliary-assembly
#20
Yuya Nishijima, Yohei Hagiya, Tomohiro Kubo, Ryota Takei, Yohei Katoh, Kazuhisa Nakayama
Proteins localized to the basal body and the centrosome play crucial roles in ciliary assembly and function. Although RABL2 and CEP19 are conserved in ciliated organisms and have been implicated in ciliary/flagellar functions, their roles are poorly understood. Here we show that RABL2 interacts with CEP19 and is recruited to the mother centriole and basal body in a CEP19-dependent manner and that CEP19 is recruited to the centriole probably via its binding to the centrosomal protein FGFR1OP. Disruption of the RABL2 gene in Chlamydomonas reinhardtii results in the nonflagellated phenotype, suggesting a crucial role of RABL2 in ciliary/flagellar assembly...
June 15, 2017: Molecular Biology of the Cell
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