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https://www.readbyqxmd.com/read/28087496/digital-pills-to-measure-opioid-ingestion-patterns-in-emergency-department-patients-with-acute-fracture-pain-a-pilot-study
#1
Peter R Chai, Stephanie Carreiro, Brendan J Innes, Rochelle K Rosen, Conall O'Cleirigh, Kenneth H Mayer, Edward W Boyer
BACKGROUND: Nonadherence to prescribed regimens for opioid analgesic agents contributes to increasing opioid abuse and overdose death. Opioids are frequently prescribed on an as-needed basis, placing the responsibility to determine opioid dose and frequency with the patient. There is wide variability in physician prescribing patterns because of the lack of data describing how patients actually use as-needed opioid analgesics. Digital pill systems have a radiofrequency emitter that directly measures medication ingestion events, and they provide an opportunity to discover the dose, timing, and duration of opioid therapy...
January 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28081172/influence-of-corneal-opacity-on-intraocular-pressure-assessment-in-patients-with-lysosomal-storage-diseases
#2
Joanna Wasielica-Poslednik, Giuseppe Politino, Irene Schmidtmann, Katrin Lorenz, Katharina Bell, Norbert Pfeiffer, Susanne Pitz
AIMS: To investigate an influence of mucopolysaccharidosis (MPS)- and Morbus Fabry-associated corneal opacities on intraocular pressure (IOP) measurements and to evaluate the concordance of the different tonometry methods. METHODS: 25 MPS patients with or without corneal clouding, 25 Fabry patients with cornea verticillata ≥ grade 2 and 25 healthy age matched controls were prospectively included into this study. Outcome measures: Goldmann applanation tonometry (GAT); palpatory assessment of IOP; Goldmann-correlated intraocular pressure (IOPg), corneal-compensated intraocular pressure (IOPcc), corneal resistance factor (CRF) and corneal hysteresis (CH) assessed by Ocular Response Analyzer (ORA); central corneal thickness (CCT) and density assessed with Pentacam...
2017: PloS One
https://www.readbyqxmd.com/read/28079074/climate-change-save-last-cloud-forests-in-western-andes
#3
Jens Mutke, Tim Böhnert, Maximilian Weigend
No abstract text is available yet for this article.
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28078499/carbonaceous-chondrite-meteorites-the-chronicle-of-a-potential-evolutionary-path-between-stars-and-life
#4
Sandra Pizzarello, Everett Shock
The biogenic elements, H, C, N, O, P and S, have a long cosmic history, whose evolution can still be observed in diverse locales of the known universe, from interstellar clouds of gas and dust, to pre-stellar cores, nebulas, protoplanetary discs, planets and planetesimals. The best analytical window into this cosmochemical evolution as it neared Earth has been provided so far by the small bodies of the Solar System, some of which were not significantly altered by the high gravitational pressures and temperatures that accompanied the formation of larger planets and may carry a pristine record of early nebular chemistry...
January 11, 2017: Origins of Life and Evolution of the Biosphere
https://www.readbyqxmd.com/read/28076440/application-of-a-cloud-model-set-pair-analysis-in-hazard-assessment-for-biomass-gasification-stations
#5
Fang Yan, Kaili Xu
Because a biomass gasification station includes various hazard factors, hazard assessment is needed and significant. In this article, the cloud model (CM) is employed to improve set pair analysis (SPA), and a novel hazard assessment method for a biomass gasification station is proposed based on the cloud model-set pair analysis (CM-SPA). In this method, cloud weight is proposed to be the weight of index. In contrast to the index weight of other methods, cloud weight is shown by cloud descriptors; hence, the randomness and fuzziness of cloud weight will make it effective to reflect the linguistic variables of experts...
2017: PloS One
https://www.readbyqxmd.com/read/28075633/reckoning-with-the-rise-of-the-carceral-state
#6
David H Cloud
No abstract text is available yet for this article.
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28075347/sdtcp-towards-datacenter-tcp-congestion-control-with-sdn-for-iot-applications
#7
Yifei Lu, Zhen Ling, Shuhong Zhu, Ling Tang
The Internet of Things (IoT) has gained popularity in recent years. Today's IoT applications are now increasingly deployed in cloud platforms to perform Big Data analytics. In cloud data center networks (DCN), TCP incast usually happens when multiple senders simultaneously communicate with a single receiver. However, when TCP incast happens, DCN may suffer from both throughput collapse for TCP burst flows and temporary starvation for TCP background flows. In this paper, we propose a software defined network (SDN)-based TCP congestion control mechanism, referred to as SDTCP, to leverage the features, e...
January 8, 2017: Sensors
https://www.readbyqxmd.com/read/28075343/a-fast-synthetic-aperture-radar-raw-data-simulation-using-cloud-computing
#8
Zhixin Li, Dandan Su, Haijiang Zhu, Wei Li, Fan Zhang, Ruirui Li
Synthetic Aperture Radar (SAR) raw data simulation is a fundamental problem in radar system design and imaging algorithm research. The growth of surveying swath and resolution results in a significant increase in data volume and simulation period, which can be considered to be a comprehensive data intensive and computing intensive issue. Although several high performance computing (HPC) methods have demonstrated their potential for accelerating simulation, the input/output (I/O) bottleneck of huge raw data has not been eased...
January 8, 2017: Sensors
https://www.readbyqxmd.com/read/28074840/observational-evidence-for-cloud-cover-enhancement-over-western-european-forests
#9
Adriaan J Teuling, Christopher M Taylor, Jan Fokke Meirink, Lieke A Melsen, Diego G Miralles, Chiel C van Heerwaarden, Robert Vautard, Annemiek I Stegehuis, Gert-Jan Nabuurs, Jordi Vilà-Guerau de Arellano
Forests impact regional hydrology and climate directly by regulating water and heat fluxes. Indirect effects through cloud formation and precipitation can be important in facilitating continental-scale moisture recycling but are poorly understood at regional scales. In particular, the impact of temperate forest on clouds is largely unknown. Here we provide observational evidence for a strong increase in cloud cover over large forest regions in western Europe based on analysis of 10 years of 15 min resolution data from geostationary satellites...
January 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28073251/interfaces-select-specific-stereochemical-conformations-the-isomerization-of-glyoxal-at-the-liquid-water-interface
#10
Chongqin Zhu, Sabre Kais, Xiao Cheng Zeng, Joseph S Francisco, Ivan Gladich
Interfacial chemistry involving glyoxal at aerosol surfaces is postulated to catalyze aerosol growth. This chemistry remains speculative due to a lack of detailed information concerning the physicochemical behavior of glyoxal at the interface of atmospheric aerosols. Here, we report results from high-level electronic structure calculations as well as both classical and Born-Oppenheimer ab initio molecular dynamics simulations of glyoxal solvation at the air/liquid water interface. When compared to the gas phase, the trans to cis isomerization of glyoxal at the liquid water interface is found to be catalyzed; additionally, the trans conformation is selectively solvated within the bulk to a greater degree than is the cis conformation...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28072883/variability-in-the-effectiveness-of-two-ornithological-survey-methods-between-tropical-forest-ecosystems
#11
Thomas Edward Martin, Josh Nightingale, Jack Baddams, Joseph Monkhouse, Aronika Kaban, Hafiyyan Sastranegara, Yeni Mulyani, George Alan Blackburn, Wilf Simcox
Birds are a frequently chosen group for biodiversity monitoring as they are comparatively straightforward and inexpensive to sample and often perform well as ecological indicators. Two commonly used techniques for monitoring tropical forest bird communities are point counts and mist nets. General strengths and weaknesses of these techniques have been well-defined; however little research has examined how their effectiveness is mediated by the ecology of bird communities and their habitats. We examine how the overall performance of these methodologies differs between two widely separated tropical forests-Cusuco National Park (CNP), a Honduran cloud forest, and the lowland forests of Buton Forest Reserves (BFR) located on Buton Island, Indonesia...
2017: PloS One
https://www.readbyqxmd.com/read/28072580/in-vivo-real-time-cavitation-imaging-in-moving-organs
#12
B Arnal, J Baranger, C Demene, M Tanter, M Pernot
The stochastic nature of cavitation implies visualization of the cavitation cloud in real-time and in a discriminative manner for the safe use of focused ultrasound therapy. This visualization is sometimes possible with standard echography, but it strongly depends on the quality of the scanner, and is hindered by difficulty in discriminating from highly reflecting tissue signals in different organs. A specific approach would then permit clear validation of the cavitation position and activity. Detecting signals from a specific source with high sensitivity is a major problem in ultrasound imaging...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28070989/fullerenes-in-space
#13
John Paul Maier, Ewen Kyle Campbell
In 1985 the football structure of $\textrm{C}_{60}$, buckminsterfullerene was proposed and subsequently confirmed following its macroscopic synthesis in 1990. From the very beginning the role of $\textrm{C}_{60}$ and $\textrm{C}_{60}^{+}$ in space was considered, particularly in the context of the enigmatic diffuse interstellar bands. These are absorption features found in the spectra of reddened star light. The first astronomical observations were made around one hundred years ago and despite significant efforts none of the interstellar molecules responsible have been identified...
January 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28070700/clouds-homogenize-shoot-temperatures-transpiration-and-photosynthesis-within-crowns-of-abies-fraseri-pursh-poiret
#14
J Melissa Hernandez-Moreno, Nicole M Bayeur, Harold D Coley, Nicole M Hughes
Multiple studies have examined the effects of clouds on shoot and canopy-level microclimate and physiological processes; none have yet done so on the scale of individual plant crowns. We compared incident photosynthetically active radiation (PAR), leaf temperatures, chlorophyll fluorescence, and photosynthetic gas exchange of shoots in three different spatial locations of Abies fraseri crowns on sunny (clear to partly cloudy) versus overcast days. The field site was a Fraser fir farm (1038 m elevation) in the Appalachian mountains, USA...
January 10, 2017: Oecologia
https://www.readbyqxmd.com/read/28066963/phenotiki-an-open-software-and-hardware-platform-for-affordable-and-easy-image-based-phenotyping-of-rosette-shaped-plants
#15
Massimo Minervini, Mario Valerio Giuffrida, Pierdomenico Perata, Sotirios A Tsaftaris
Phenotyping is important to understand plant biology but current solutions are either costly, not versatile or difficult to deploy. To solve this problem, we present Phenotiki, an affordable system for plant phenotyping which, relying on off-the-shelf parts, provides an easy to install and maintain platform, offering an out-of-box experience for a well established phenotyping need: imaging rosette-shaped plants. The accompanying software (with available source code) processes data originating from our device seamlessly and automatically...
January 9, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28066694/ice-residual-properties-in-mixed-phase-clouds-at-the-high-alpine-jungfraujoch-site
#16
Piotr Kupiszewski, Marco Zanatta, Stephan Mertes, Paul Vochezer, Gary Lloyd, Johannes Schneider, Ludwig Schenk, Martin Schnaiter, Urs Baltensperger, Ernest Weingartner, Martin Gysel
Ice residual (IR) and total aerosol properties were measured in mixed-phase clouds (MPCs) at the high-alpine Jungfraujoch research station. Black carbon (BC) content and coating thickness of BC-containing particles were determined using single-particle soot photometers. The ice activated fraction (IAF), derived from a comparison of IR and total aerosol particle size distributions, showed an enrichment of large particles in the IR, with an increase in the IAF from values on the order of 10(-4) to 10(-3) for 100 nm (diameter) particles to 0...
October 27, 2016: Journal of Geophysical Research. Atmospheres: JGR
https://www.readbyqxmd.com/read/28065898/metaspark-a-spark-based-distributed-processing-tool-to-recruit-metagenomic-reads-to-reference-genomes
#17
Wei Zhou, Ruilin Li, Shuo Yuan, ChangChun Liu, Shaowen Yao, Jing Luo, Beifang Niu
: With the advent of next-generation sequencing, traditional bioinformatics tools are challenged by massive raw metagenomic datasets. One of the bottlenecks of metagenomic studies is lack of large-scale and cloud computing suitable data analysis tools. In this paper, we proposed a Spark -: based tool, called MetaSpark, to recruit metagenomic reads to reference genomes. MetaSpark benefits from the distributed data set (RDD) of Spark, which makes it able to cache data set in memory across cluster nodes and scale well with the datasets...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28063110/toward-the-next-step-in-g-protein-coupled-receptor-research-a-knowledge-driven-analysis-for-the-next-potential-targets-in-drug-discovery
#18
Koji Nagata, Yukie Katayama, Tomomi Sato, Yeondae Kwon, Takeshi Kawabata
More than 800 G protein-coupled receptor (GPCR) genes have been discovered in the human genome. Towards the next step in GPCR research, we performed a knowledge-driven analysis of orphan class-A GPCRs that may serve as novel targets in drug discovery. We examined the relationship between 61 orphan class-A GPCR genes and diseases using the Online Mendelian Inheritance in Man (OMIM) database and the DDSS tool. The OMIM database contains data on disease-related variants of the genes. Particularly, the variants of GPR101, GPR161, and GPR88 are related to the genetic diseases: growth hormone-secreting pituitary adenoma 2, pituitary stalk interruption syndrome (not confirmed), and childhood-onset chorea with psychomotor retardation, respectively...
January 6, 2017: Journal of Structural and Functional Genomics
https://www.readbyqxmd.com/read/28062191/tracking-hcv-protease-population-diversity-during-transmission-and-susceptibility-of-founder-populations-to-antiviral-therapy
#19
Tanvi Khera, Daniel Todt, Koen Vercauteren, C Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J P Brown
Due to the highly restricted species-tropism of Hepatitis C virus (HCV) a limited number of animal models exist for pre-clinical evaluation of vaccines and antiviral compounds. The human-liver chimeric mouse model allows heterologous challenge with clinically relevant strains derived from patients. However, to date, the transmission and longitudinal evolution of founder viral populations in this model have not been characterized in-depth using state-of-the-art sequencing technologies. Focusing on NS3 protease encoding region of the viral genome, mutant spectra in a donor inoculum and individual recipient mice were determined via Illumina sequencing and compared, to determine the effects of transmission on founder viral population complexity...
January 3, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28060298/knowledge-based-cloud-fe-simulation-of-sheet-metal-forming-processes
#20
Du Zhou, Xi Yuan, Haoxiang Gao, Ailing Wang, Jun Liu, Omer El Fakir, Denis J Politis, Liliang Wang, Jianguo Lin
The use of Finite Element (FE) simulation software to adequately predict the outcome of sheet metal forming processes is crucial to enhancing the efficiency and lowering the development time of such processes, whilst reducing costs involved in trial-and-error prototyping. Recent focus on the substitution of steel components with aluminum alloy alternatives in the automotive and aerospace sectors has increased the need to simulate the forming behavior of such alloys for ever more complex component geometries...
December 13, 2016: Journal of Visualized Experiments: JoVE
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