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Medicinal marijuana

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https://www.readbyqxmd.com/read/27900531/accidental-cannabis-poisoning-in-the-elderly
#1
Anja Zupan Mežnar, Miran Brvar, Gregor Kralj, Dragan Kovačič
There are two main varieties of Cannabis sativa plant, namely, hemp which is cultivated for fiber and seeds and contains low amounts of psychoactive cannabinoids and the other which is cultivated for the drug cannabis or marijuana. Increasing popularity of hemp food products and alleged beneficial effects of cannabinoids in the drug variety of cannabis might lead to confusion in the lay population and unintentional ingestion of marijuana, as described in this case report. During a workshop on the use of hemp for medicinal purposes, there was a degustation of various hemp food products including also cookies that were brought by one of the attendees...
November 29, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27846066/prevalence-and-patterns-of-marijuana-use-in-young-adults-with-inflammatory-bowel-disease
#2
Uma Padhye Phatak, Danilo Rojas-Velasquez, Anthony Porto, Dinesh S Pashankar
OBJECTIVES: Recent studies in adults report symptom relief with marijuana use in patients with inflammatory bowel disease (IBD). We assessed the prevalence, pattern, effects and adverse effects of marijuana use in young adults with IBD. METHODS: We conducted a prospective questionnaire survey study at a pediatric IBD clinic. All patients (18 to 21 years of age) answered anonymous questionnaires about demographics, IBD, medications and marijuana use. RESULTS: Fifty-three patients (Mean age 18...
November 14, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27832442/cannabinoids-in-the-management-of-musculoskeletal-or-rheumatic-diseases
#3
REVIEW
Mary-Ann Fitzcharles, Winfried Häuser
The endocannabinoid system impacts pain and inflammation with potential for therapeutic effect on patients with rheumatic diseases. The current treatment options include the herbal product derived from the plant Cannabis sativa, as well as pharmaceutical preparations. The legalization of medicinal cannabis (marijuana) in many jurisdictions and widespread public advocacy has propelled an interest in use either by prescription or self-medication. In this review, we examine current evidence for efficacy and adverse effects of any cannabinoid product in rheumatic conditions...
December 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27829351/recent-updates-in-imperative-natural-compounds-for-healthy-brain-and-nerve-function-a-systematic-review-of-implications-for-multiple-sclerosis
#4
Nima Sanadgol, Shahram Shahraki Zahedani, Mohammad Sharifzadeh, Roghayeh Khalseh, Gullam Reza Barbari, Mohammad Abdollahi
BACKGROUND: The evolution of the 'Green' movement in western society has changed attitudes in the general population who now perceive natural compounds as being inherently harmless and more desirable than artificial chemical products. OBJECTIVE: Considering the growing interest towards introducing naturally emerged medicines, the purpose of this review was to overview the ongoing research into prevention and treatment of multiple sclerosis (MS) lesions. METHOD: This review was carried out by searching bibliographic databases such as PubMed and Scopus for studies reported between 1th January 2008 to 30rd January 2016 on MS patients or animal models of MS, investigating the beneficial effects of natural compounds in MS treatment...
November 8, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27798074/stability-of-tetrahydrocannabinol-and-cannabidiol-in-prepared-quality-control-medible-brownies
#5
Carl E Wolf, Justin L Poklis, Alphonse Poklis
The legalization of marijuana in the USA for both medicinal and recreational use has increased in the past few years. Currently, 24 states have legalized marijuana for medicinal use. The US Drug Enforcement Administration has classified marijuana as a Schedule I substance. The US Food and Drug Administration does not regulate formulations or packages of marijuana that are currently marketed in states that have legalized marijuana. Marijuana edibles or "medibles" are typically packages of candies and baked goods consumed for medicinal as well as recreational marijuana use...
October 18, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27789118/adverse-structural-and-functional-effects-of-marijuana-on-the-brain-evidence-reviewed
#6
REVIEW
David E Mandelbaum, Suzanne M de la Monte
The growing use and legalization of cannabis are leading to increased exposures across all age groups, including in adolescence. The touting of its medicinal values stems from anecdotal reports related to treatment of a broad range of illnesses including epilepsy, multiple sclerosis, muscle spasms, arthritis, obesity, cancer, Alzheimer disease, Parkinson disease, post-traumatic stress, inflammatory bowel disease, and anxiety. However, it is essential that anecdotal data and the high level of interest in this treatment not obscure objective assessments of any potential and realized short- and long-term adverse effects of cannabis, particularly with respect to age of onset and chronicity of exposure...
September 13, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27757048/medical-cannabis-the-canadian-perspective
#7
Gordon D Ko, Sara L Bober, Sean Mindra, Jason M Moreau
Cannabis has been widely used as a medicinal agent in Eastern medicine with earliest evidence in ancient Chinese practice dating back to 2700 BC. Over time, the use of medical cannabis has been increasingly adopted by Western medicine and is thus a rapidly emerging field that all pain physicians need to be aware of. Several randomized controlled trials have shown a significant and dose-dependent relationship between neuropathic pain relief and tetrahydrocannabinol - the principal psychoactive component of cannabis...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27750182/prevalence-and-correlates-of-substance-use-among-youth-living-with-hiv-in-clinical-settings
#8
Kristi E Gamarel, Larry Brown, Christopher W Kahler, M Isabel Fernandez, Douglas Bruce, Sharon Nichols
OBJECTIVES: The purpose of this study was to better understand the prevalence and correlates of substance use behaviors among HIV-infected adolescents in HIV care settings. METHODS: A cross-sectional sample of 2216 youth living with HIV (YLWH; ages 12-26) were recruited through the Adolescent Trials Network for HIV Interventions. Participants completed a one-time survey on sociodemographic factors, substance use and health behaviors. We used logistic regression models to understand the correlates of substance use outcomes...
December 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27749797/adolescent-intentional-abuse-ingestions-overall-10-year-trends-and-regional-variation
#9
David C Sheridan, Robert G Hendrickson, Gillian Beauchamp, Amber Laurie, Rongwei Fu, B Zane Horowitz
OBJECTIVE: Adolescent intentional ingestions remain a significant public health problem in the United States with little research to date on the over-the-counter or prescription medicines that adolescents abuse. These data are important for anticipatory guidance by primary care providers, preventive health, and poison center outreach. METHODS: This was an observational study using the American Association of Poison Control Centers National Poison Data System. The study population consisted of all cases of patients aged 13 to 19 years from 2004 to 2013 with a coding of "intentional abuse...
October 4, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27719666/cannabis-a-treasure-trove-or-pandora-s-box
#10
Katalin Solymosi, Attila Köfalvi
Cannabis is one of the earliest cultivated plants. Cannabis of industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is bred for medical, spiritual and recreational purposes is called marijuana. The female marijuana plant produces a significant quantity of bio- and psychoactive phytocannabinoids, which regained the spotlight with the discovery of the endocannabinoid system of the animals in the early 90's. Nevertheless, marijuana is surrounded by controversies, debates and misconceptions related to its taxonomic classification, forensic identification, medical potential, legalization and its long-term health consequences...
October 4, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27673500/near-infrared-spectroscopy-combined-with-chemometrics-for-growth-stage-classification-of-cannabis-cultivated-in-a-greenhouse-from-seized-seeds
#11
Bruna Tassi Borille, Marcelo Caetano Alexandre Marcelo, Rafael Scorsatto Ortiz, Kristiane de Cássia Mariotti, Marco Flôres Ferrão, Renata Pereira Limberger
Cannabis sativa L. (cannabis, Cannabaceae), popularly called marijuana, is one of the oldest plants known to man and it is the illicit drug most used worldwide. It also has been the subject of increasing discussions from the scientific and political points of view due to its medicinal properties. In recent years in Brazil, the form of cannabis drug trafficking has been changing and the Brazilian Federal Police has exponentially increased the number of seizures of cannabis seeds sent by the mail. This new form of trafficking encouraged the study of cannabis seeds seized germinated in a greenhouse through NIR spectroscopy combined with chemometrics...
September 22, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27660881/use-of-marijuana-for-medical-purposes
#12
EDITORIAL
Jarosław Pinkas, Piotr Jabłoński, Michal Kidawa, Waldemar Wierzba
Cannabis is the most popular illicit drug on the European market. Over 16 million young Europeans have used it at least once in the last few years. The recent trends in the consumption of marihuana differ between countries. Some countries face an increase in the prevalence of cannabis use, including Poland, where the level cannabis use has been systematically increasing since the 1990's. According to a recent ESPAD study, 19% of Polish adolescents aged 15-16 have used cannabis in the last year. Marihuana is also a leading substance when analyzing the data of seizures and crimes...
September 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/27579692/cannabis-and-pediatric-inflammatory-bowel-disease-change-blossoms-a-mile-high
#13
Edward J Hoffenberg, Heike Newman, Colm Collins, Kristina Leinwand, Sally Tarbell
The trend towards decriminalization of cannabis (marijuana) continues sweeping across the United States. Colorado has been a leader of legalization of medical and recreational cannabis use. The growing public interest in the medicinal properties of cannabis and its use by patients with a variety of illnesses including inflammatory bowel disease (IBD) makes it important for pediatric gastroenterologists to understand this movement and its potential impact on patients. This article describes the path to legalization and "medicalization" of cannabis in Colorado as well as the public perception of safety despite the known adverse health effects of use...
August 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27561826/the-gastrointestinal-tract-a-central-organ-of-cannabinoid-signaling-in-health-and-disease
#14
REVIEW
C Hasenoehrl, U Taschler, M Storr, R Schicho
BACKGROUND: In ancient medicine, extracts of the marijuana plant Cannabis sativa were used against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of the Cannabis plant has remarkably advanced enabling us to use a variety of herbal and synthetic cannabinoid (CB) compounds to study the endocannabinoid system (ECS), a physiologic entity that controls tissue homeostasis with the help of endogenously produced CBs and their receptors. After many anecdotal reports suggested beneficial effects of Cannabis in GI disorders, it was not surprising to discover that the GI tract accommodates and expresses all the components of the ECS...
December 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27428345/-cannabis-effects-in-the-central-nervous-system-therapeutic-societal-and-legal-consequences
#15
Víctor Manuel Rivera-Olmos, Marisela C Parra-Bernal
The consumption of marijuana extracted from Cannabis sativa and indica plants involves an important cultural impact in Mexico. Their psychological stimulatory effect is widely recognized; their biochemical and molecular components interact with CB1 and CB2 (endocannabinoid system) receptors in various central nervous system structures (CNS) and immune cells. The psychoactive element Δ-9-tetrahydrocannabinol (THC) can be reproduced synthetically. Systematic reviews show evidence of therapeutic effectiveness of therapeutic marijuana only for certain symptoms of multiple sclerosis (spasticity, spasms and pain), despite attempts for its widespread use, including refractory childhood epilepsy...
September 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27268054/rna-seq-analysis-of-%C3%AE-9-tetrahydrocannabinol-treated-t-cells-reveals-altered-gene-expression-profiles-that-regulate-immune-response-and-cell-proliferation
#16
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Marijuana has drawn significant public attention and concern both for its medicinal and recreational use. Δ9-Tetrahydrocannabinol (THC), which is the main bioactive component in marijuana, has also been shown to possess potent anti-inflammatory properties by virtue of its ability to activate cannabinoid receptor-2 (CB-2) expressed on immune cells. In this study, we used RNA-seq to quantify the transcriptomes and transcript variants that are differentially regulated by THC in super antigen-activated lymph node cells and CD4(+) T cells...
July 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27191472/capturing-heterogeneity-in-medical-marijuana-policies-a-taxonomy-of-regulatory-regimes-across-the-united-states
#17
Susan A Chapman, Joanne Spetz, Jessica Lin, Krista Chan, Laura A Schmidt
BACKGROUND: There is considerable movement in the U.S. to legalize use of cannabis for medicinal purposes. Twenty-three U.S. states and the District of Columbia have laws that decriminalize use of marijuana for medicinal purposes. Most prior studies of state medical marijuana laws and their association with overall marijuana use, adolescent use, crime rates, and alcohol traffic fatalities have used a binary coding of whether the state had a medical marijuana law or not. Mixed results from these studies raise the question of whether this method for measuring policy characteristics is adequate...
July 28, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27172576/measuring-protective-behavioral-strategies-for-marijuana-use-among-young-adults
#18
Eric R Pedersen, Justin F Hummer, Dipali Venkataraman Rinker, Zach K Traylor, Clayton Neighbors
OBJECTIVE: Marijuana use can result in a variety of negative consequences, yet it remains popular among young adults and the general public at large. Combined with the growing empirical support for the benefits of medicinal marijuana as well as the steady increase in popular opinion regarding its legalization, it is of growing importance to identify strategies that may mitigate the harms related to marijuana use, reduce consumption levels, and limit resulting negative consequences among young adults who use marijuana...
May 2016: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27139708/pediatric-concerns-due-to-expanded-cannabis-use-unintended-consequences-of-legalization
#19
George Sam Wang
An "unintended consequence" of marijuana legalization is the impact on the pediatric population. From prenatal exposure to unintentional childhood exposures, through concerns of adolescence abuse and marijuana use for medicinal indications in children, marijuana exposure can affect pediatric patients at every stage in childhood. Regardless of the stage or reason of exposure, concerns exist about short-term and long-term consequences in a child's physical and mental health. The use of cannabidiol (CBD) may have some benefit for the treatment of epilepsy, but emphasis needs to be on rigorous clinical trials to evaluate efficacy and safety...
May 2, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27108324/in-vitro-propagation-of-cannabis-sativa-l-and-evaluation-of-regenerated-plants-for-genetic-fidelity-and-cannabinoids-content-for-quality-assurance
#20
Hemant Lata, Suman Chandra, Ikhlas A Khan, Mahmoud A ElSohly
Cannabis sativa L. (Marijuana; Cannabaceae), one of the oldest medicinal plants in the world, has been used throughout history for fiber, food, as well as for its psychoactive properties. The dioecious and allogamous nature of C. sativa is the major constraint to maintain the consistency in chemical profile and overall efficacy if grown from seed. Therefore, the present optimized in vitro propagation protocol of the selected elite germplasm via direct organogenesis and quality assurance protocols using genetic and chemical profiling provide an ideal pathway for ensuring the efficacy of micropropagated Cannabis sativa germplasm...
2016: Methods in Molecular Biology
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