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https://www.readbyqxmd.com/read/27918551/hepatocarcinogenesis-in-transgenic-mice-carrying-hepatitis-b-virus-pre-s-s-gene-with-the-sw172-mutation
#1
M-W Lai, K-H Liang, W-R Lin, Y-H Huang, S-F Huang, T-C Chen, C-T Yeh
Hepatitis B virus (HBV) carrying the rtA181T/sW172* mutation conferred cross-resistance to adefovir and lamivudine. Cell-based and clinical studies indicated that HBV carrying this mutation had an increased oncogenic potential. Herein, we created transgenic mouse models to study the oncogenicity of the HBV pre-S/S gene containing this mutation. Transgenic mice were generated by transfer of the HBV pre-S/S gene together with its own promoter into C57B6 mice. Four lines of mice were created. Two of them carried wild-type gene and produced high and low levels of HBV surface antigen (HBsAg) (TgWT-H and L)...
December 5, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27775699/susd2-expression-in-high-grade-serous-ovarian-cancer-correlates-with-increased-patient-survival-and-defective-mesothelial-clearance
#2
J N Sheets, M Iwanicki, J F Liu, B E Howitt, M S Hirsch, J A A Gubbels, R Drapkin, K A Egland
The cause of death among the majority of epithelial ovarian cancer (EOC) patients involves passive dissemination of cancer cells within the peritoneal cavity and subsequent implantation of cancer spheroids into adjacent organs. Thus, it is important to identify the factors that mediate EOC metastasis and implantation, including clearance of the mesothelium. Sushi domain containing 2 (SUSD2) encodes a type I transmembrane protein containing several functional domains inherent to adhesion molecules. Immunohistochemical analysis determined the presence of SUSD2 in several subtypes of EOC, with the strongest staining observed in high-grade serous ovarian carcinomas (HGSOCs)...
October 24, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27764775/complement-inhibitor-csmd1-acts-as-tumor-suppressor-in-human-breast-cancer
#3
Astrid Escudero-Esparza, Michael Bartoschek, Chrysostomi Gialeli, Marcin Okroj, Sioned Owen, Karin Jirström, Akira Orimo, Wen G Jiang, Kristian Pietras, Anna M Blom
Human CUB and Sushi multiple domains 1 (CSMD1) is a membrane-bound complement inhibitor suggested to act as a putative tumor suppressor gene, since allelic loss of this region encompassing 8p23 including CSMD1 characterizes various malignancies. Here, we assessed the role of CSMD1 as a tumor suppressor gene in the development of breast cancer in vitro and in vivo. We found that human breast tumor tissues expressed CSMD1 at lower levels compared to that in normal mammary tissues. The decreased expression of CSMD1 was linked to a shorter overall survival of breast cancer patients...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27756250/mir-10b-exerts-oncogenic-activity-in-human-hepatocellular-carcinoma-cells-by-targeting-expression-of-cub-and-sushi-multiple-domains-1-csmd1
#4
Qiao Zhu, Li Gong, Jun Wang, Qian Tu, Li Yao, Jia-Rui Zhang, Xiu-Juan Han, Shao-Jun Zhu, Shu-Mei Wang, Yan-Hong Li, Wei Zhang
BACKGROUND: Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This study assessed expression and the oncogenic activity of miRNA-10b (miR-10b) in HCC. METHODS: Forty-five paired human HCC and adjacent non-tumor tissues were collected for qRT-PCR and immunohistochemistry analysis of miR-10b and CUB and Sushi multiple domains 1 (CSMD1), respectively...
October 18, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27650494/a-novel-fusion-of-alt-803-interleukin-il-15-superagonist-with-an-antibody-demonstrates-antigen-specific-antitumor-responses
#5
Bai Liu, Lin Kong, Kaiping Han, Hao Hong, Warren D Marcus, Xiaoyue Chen, Emily K Jeng, Sarah Alter, Xiaoyun Zhu, Mark P Rubinstein, Sixiang Shi, Peter R Rhode, Weibo Cai, Hing C Wong
IL-15 and its receptor α (IL-15Rα) are co-expressed on antigen-presenting cells, allowing transpresentation of IL-15 to immune cells bearing IL-2RβγC and stimulation of effector immune responses. We reported previously that the high-affinity interactions between an IL-15 superagonist (IL-15N72D) and the extracellular IL-15Rα sushi domain (IL-15RαSu) could be exploited to create a functional scaffold for the design of multivalent disease-targeted complexes. The IL-15N72D·IL-15RαSuFc complex, also known as ALT-803, is a multimeric complex constructed by fusing IL-15N72D·IL-15RαSu to the Fc domain of IgG1...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27595206/mycobacterium-marinum-skin-infection-in-a-sushi-cook
#6
Stefano Veraldi, Ermira Çuka, Fabrizio Vaira, Gianluca Nazzaro
No abstract text is available yet for this article.
October 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27498877/phospho-dependent-accumulation-of-gababrs-at-presynaptic-terminals-after-nmdar-activation
#7
Saad Hannan, Kim Gerrow, Antoine Triller, Trevor G Smart
Here, we uncover a mechanism for regulating the number of active presynaptic GABAB receptors (GABABRs) at nerve terminals, an important determinant of neurotransmitter release. We find that GABABRs gain access to axon terminals by lateral diffusion in the membrane. Their relative accumulation is dependent upon agonist activation and the presence of the two distinct sushi domains that are found only in alternatively spliced GABABR1a subunits. Following brief activation of NMDA receptors (NMDARs) using glutamate, GABABR diffusion is reduced, causing accumulation at presynaptic terminals in a Ca(2+)-dependent manner that involves phosphorylation of GABABR2 subunits at Ser783...
August 16, 2016: Cell Reports
https://www.readbyqxmd.com/read/27493247/ampk-dependent-regulation-of-glp1-expression-in-l-like-cells
#8
Sushi Jiang, Hening Zhai, Danjie Li, Jiana Huang, Heng Zhang, Ziru Li, Weizhen Zhang, Geyang Xu
This study examined whether AMPK, an evolutionarily conserved sensor of cellular energy status, determines the production of glucagon-like peptide-1 (GLP1). A negative relation existed between phosphorylation of AMPKα and the expression and secretion of GLP1 during changes in energy status in STC-1 cells, an L-like cell line. High concentration of glucose (25 mmol/L) decreased AMPKα phosphorylation, whereas it stimulated the expression and secretion of GLP1 relative to 5.6 mmol/L glucose. Serum starvation upregulated AMPKα phosphorylation, whereas it reduced GLP1 production significantly...
October 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27488533/stimulation-of-natural-killer-cell-mediated-tumor-immunity-by-an-il15-tgf%C3%AE-neutralizing-fusion-protein
#9
Spencer Ng, Jiusheng Deng, Raghavan Chinnadurai, Shala Yuan, Andrea Pennati, Jacques Galipeau
The clinical efficacy of immune cytokines used for cancer therapy is hampered by elements of the immunosuppressive tumor microenvironment such as TGFβ. Here we demonstrate that FIST15, a recombinant chimeric protein composed of the T-cell-stimulatory cytokine IL15, the sushi domain of IL15Rα and a TGFβ ligand trap, can overcome immunosuppressive TGFβ to effectively stimulate the proliferation and activation of natural killer (NK) and CD8(+) T cells with potent antitumor properties. FIST15-treated NK and CD8(+) T cells produced more IFNγ and TNFα compared with treatment with IL15 and a commercially available TGFβ receptor-Fc fusion protein (sTβRII) in the presence of TGFβ...
October 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27446905/an-ltr-retrotransposon-derived-gene-displays-lineage-specific-structural-and-putative-species-specific-functional-variations-in-eutherians
#10
Masahito Irie, Akihiko Koga, Tomoko Kaneko-Ishino, Fumitoshi Ishino
Amongst the 11 eutherian-specific genes acquired from a sushi-ichi retrotransposon is the CCHC type zinc-finger protein-encoding gene SIRH11/ZCCHC16. Its contribution to eutherian brain evolution is implied because of its involvement in cognitive function in mice, possibly via the noradrenergic system. Although, the possibility that Sirh11/Zcchc16 functions as a non-coding RNA still remains, dN/dS ratios in pairwise comparisons between its orthologs have provided supportive evidence that it acts as a protein...
2016: Frontiers in Chemistry
https://www.readbyqxmd.com/read/27377754/no-association-between-the-rs10503253-polymorphism-in-the-csmd1-gene-and-schizophrenia-in-a-han-chinese-population
#11
Yansong Liu, Zaohuo Cheng, Jun Wang, Chunhui Jin, Jianmin Yuan, Guoqiang Wang, Fuquan Zhang, Xudong Zhao
BACKGROUND: Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population. METHODS: We conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27345758/the-consumption-of-fish-cooked-by-different-methods-was-related-to-the-risk-of-hyperuricemia-in-japanese-adults-a-3-year-follow-up-study
#12
Z Ren, C Huang, H Momma, Y Cui, S Sugiyama, K Niu, R Nagatomi
BACKGROUND AND AIMS: Fish consumption is a recognized risk factor for elevated serum uric acid (UA) levels, hyperuricemia, and gout. However, the relationship between the consumption of fish cooked by different methods and the risk of hyperuricemia is unclear. Therefore, we aimed to investigate the relationship between the consumption of fish cooked by different methods and the risk of hyperuricemia in Japanese adults. METHODS AND RESULTS: A 3-year follow-up study was conducted with 424 Japanese adults aged 29-74 years...
September 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27255077/sushi-an-exquisite-recipe-for-fully-documented-reproducible-and-reusable-ngs-data-analysis
#13
Masaomi Hatakeyama, Lennart Opitz, Giancarlo Russo, Weihong Qi, Ralph Schlapbach, Hubert Rehrauer
BACKGROUND: Next generation sequencing (NGS) produces massive datasets consisting of billions of reads and up to thousands of samples. Subsequent bioinformatic analysis is typically done with the help of open source tools, where each application performs a single step towards the final result. This situation leaves the bioinformaticians with the tasks to combine the tools, manage the data files and meta-information, document the analysis, and ensure reproducibility. RESULTS: We present SUSHI, an agile data analysis framework that relieves bioinformaticians from the administrative challenges of their data analysis...
2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27217584/il-15-trans-signaling-with-the-superagonist-rli-promotes-effector-memory-cd8-t-cell-responses-and-enhances-antitumor-activity-of-pd-1-antagonists
#14
Mélanie Desbois, Pauline Le Vu, Clélia Coutzac, Elie Marcheteau, Coralie Béal, Magali Terme, Alain Gey, Sébastien Morisseau, Géraldine Teppaz, Lisa Boselli, Yannick Jacques, David Béchard, Eric Tartour, Lydie Cassard, Nathalie Chaput
Tumors with the help of the surrounding environment facilitate the immune suppression in patients, and immunotherapy can counteract this inhibition. Among immunotherapeutic strategies, the immunostimulatory cytokine IL-15 could represent a serious candidate for the reactivation of antitumor immunity. However, exogenous IL-15 may have a limited impact on patients with cancer due to its dependency on IL-15Rα frequently downregulated in cancer patients. In this work, we studied the antitumor activity of the IL-15 superagonist receptor-linker-IL-15 (RLI), designed to bypass the need of endogenous IL-15Rα...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27198810/food-adulteration-in-switzerland-from-ravioli-over-springbok-to-disco-sushi
#15
Philipp Hubner
The driving force behind food adulteration is monetary profit and this has remained unchanged for at least the last hundred years. Food adulterations were and still are difficult to uncover because they occur mostly in an unpredictable and unexpected way. Very often food falsifiers take advantage of modern technology in such a way that food adulterations are difficult or sometimes even impossible to detect. Targets for food adulteration were and still are highly priced food items such as spirits, meat, seafood and olive oil...
2016: Chimia
https://www.readbyqxmd.com/read/27159596/increasing-risk-factors-for-imported-and-domestic-gnathostomiasis-in-the-united-states
#16
James H Diaz
Gnathostomiasis is a foodborne zoonotic helminthic infection, commonly described in Asia and Latin America, which may follow the consumption of raw fish, eels, amphibians, and reptiles infected with muscle-encysted larvae of Gnathostoma species nematodes. After an inoculum of as little as one infective larva and an incubation period of months to years, most infections are characterized by intermittent migratory swellings due to subdermal larval migration. Less commonly, larval migration to the central nervous system may result in radiculomyelopathy or eosinophilic meningoencephalitis with high fatality rates; or larval migration to the eye with resulting blindness in untreated cases...
September 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27138613/increasing-risk-factors-for-imported-and-domestic-gnathostomiasis-in-the-united-states
#17
James H Diaz
Gnathostomiasis is a foodborne zoonotic helminthic infection, commonly described in Asia and Latin America, which may follow the consumption of raw fish, eels, amphibians, and reptiles infected with muscle-encysted larvae of Gnathostoma species nematodes. After an inoculum of as little as one infective larva and an incubation period of months to years, most infections are characterized by intermittent migratory swellings due to subdermal larval migration. Less commonly, larval migration to the central nervous system may result in radiculomyelopathy or eosinophilic meningoencephalitis with high fatality rates; or larval migration to the eye with resulting blindness in untreated cases...
September 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27069819/sushi-barcoding-in-the-uk-another-kettle-of-fish
#18
Sara G Vandamme, Andrew M Griffiths, Sasha-Ann Taylor, Cristina Di Muri, Elizabeth A Hankard, Jessica A Towne, Mhairi Watson, Stefano Mariani
Although the spread of sushi restaurants in the European Union and United States is a relatively new phenomenon, they have rapidly become among the most popular food services globally. Recent studies indicate that they can be associated with very high levels (>70%) of fish species substitution. Based on indications that the European seafood retail sector may currently be under better control than its North American counterpart, here we investigated levels of seafood labelling accuracy in sushi bars and restaurants across England...
2016: PeerJ
https://www.readbyqxmd.com/read/27068305/shell-matrix-proteins-of-the-clam-mya-truncata-roles-beyond-shell-formation-through-proteomic-study
#19
Jaison Arivalagan, Benjamin Marie, Victoria A Sleight, Melody S Clark, Sophie Berland, Arul Marie
Mya truncata, a soft shell clam, is presented as a new model to study biomineralization through a proteomics approach. In this study, the shell and mantle tissue were analysed in order to retrieve knowledge about the secretion of shell matrix proteins (SMPs). Out of 67 and 127 shell and mantle proteins respectively, 16 were found in both shell and mantle. Bioinformatic analysis of SMP sequences for domain prediction revealed the presence of several new domains such as fucolectin tachylectin-4 pentraxin-1 (FTP), scavenger receptor, alpha-2-macroglobulin (α2 M), lipocalin and myosin tail along with previously reported SMP domains such as chitinase, carbonic anhydrase, tyrosinase, sushi, and chitin binding...
June 2016: Marine Genomics
https://www.readbyqxmd.com/read/27065071/fish-parasites-a-growing-concern-during-pregnancy
#20
Diana L Villazanakretzer, Peter G Napolitano, Kelly F Cummings, Everett F Magann
Intestinal parasitic worms affect more than 2 billion people worldwide according to the World Health Organization. Fish-borne parasitic infections are becoming more common with the increasing popularity of sushi, sashimi, Carpaccio, tartare, gefilte, and ceviche. The ingestion of these parasites can cause serve anemia, malabsorption, severe abdominal pain, nausea, vomiting, strong allergic reactions, and gastric ulcers. Knowledge about fish parasites and pregnancy is limited. A literature search on PubMed and Web of Science used the search terms "fish parasites" OR "diphyllobothrium" OR "anisakiasis" OR "pseudoterranova" OR ("food borne parasites" AND "fish") AND "pregnancy" OR "maternal" OR "fetus" OR "fetal" OR "newborn" OR "neonatal" OR "childbirth...
April 2016: Obstetrical & Gynecological Survey
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