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https://www.readbyqxmd.com/read/28475599/susd2-promotes-tumor-associated-macrophage-recruitment-by-increasing-levels-of-mcp-1-in-breast-cancer
#1
Elizabeth M Hultgren, Mitch E Patrick, Rick L Evans, Catherine T Stoos, Kristi A Egland
Tumor-associated macrophages (TAMs) play a role in tumor angiogenesis and are recruited into the tumor microenvironment (TME) by secreted chemokines, including Monocyte Chemoattractant Protein-1 (MCP-1/CCL2). Angiogenesis is required to sustain proliferation and enable metastasis of breast cancer (BCa) cells. Understanding the underlying mechanisms of TAM recruitment would allow for the identification of desperately needed novel drug targets. Sushi Domain Containing 2 (SUSD2), a transmembrane protein on BCa cells, was previously shown to promote tumor angiogenesis in a murine model...
2017: PloS One
https://www.readbyqxmd.com/read/28462733/epidemiology-and-whole-genome-sequencing-of-an-ongoing-point-source-salmonella-agona-outbreak-associated-with-sushi-consumption-in-western-sydney-australia-2015
#2
C K Thompson, Q Wang, S K Bag, N Franklin, C T Shadbolt, P Howard, E J Fearnley, H E Quinn, V Sintchenko, K G Hope
During May 2015, an increase in Salmonella Agona cases was reported from western Sydney, Australia. We examine the public health actions used to investigate and control this increase. A descriptive case-series investigation was conducted. Six outbreak cases were identified; all had consumed cooked tuna sushi rolls purchased within a western Sydney shopping complex. Onset of illness for outbreak cases occurred between 7 April and 24 May 2015. Salmonella was isolated from food samples collected from the implicated premise and a prohibition order issued...
May 2, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28437165/survey-for-listeria-monocytogenes-in-and-on-ready-to-eat-foods-from-retail-establishments-in-the-united-states-2010-through-2013-assessing-potential-changes-of-pathogen-prevalence-and-levels-in-a-decade
#3
John B Luchansky, Yuhuan Chen, Anna C S Porto-Fett, Régis Pouillot, Bradley A Shoyer, Rachel Johnson-DeRycke, Denise R Eblen, Karin Hoelzer, William K Shaw, Jane M van Doren, Michelle Catlin, Jeehyun Lee, Rohan Tikekar, Daniel Gallagher, James A Lindsay, Sherri Dennis
A multiyear interagency Listeria monocytogenes Market Basket Survey was undertaken for selected refrigerated ready-to-eat foods purchased at retail in four FoodNet sites in the United States. Food samples from 16 food categories in six broad groups (seafood, produce, dairy, meat, eggs, and combination foods) were collected weekly at large national chain supermarkets and independent grocery stores in California, Maryland, Connecticut, and Georgia for 100 weeks between December 2010 and March 2013. Of the 27,389 total samples, 116 samples tested positive by the BAX PCR system for L...
April 24, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28393817/efficacy-of-triphala-extract-and-chlorhexidine-mouth-rinse-against-plaque-accumulation-and-gingival-inflammation-among-female-undergraduates-a-randomized-controlled-trial
#4
Sahana Umesh Baratakke, Rekha Raju, Sushi Kadanakuppe, Nagashree R Savanur, Radha Gubbihal, Pallavi Swamy Kousalaya
AIM: To know the efficacy of Triphala extract and Chlorhexidine mouth rinse against plaque and gingival inflammation. MATERIALS AND METHODS: A double blinded parallel arm randomised control trial was done among 60 participants aged 18-24 years. Participants were randomly allotted to three groups with 20 participants in each group of 0.6% triphala, 0.12% chlorhexidine and control group. Study was done in 2 phases of 21 days duration. During the experimental period, participants rinsed with the allocated mouth rinse 10ml twice daily for 30 seconds without any supervision...
January 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28374770/identification-of-conserved-proteins-from-diverse-shell-matrix-proteome-in-crassostrea-gigas-characterization-of-genetic-bases-regulating-shell-formation
#5
Dandan Feng, Qi Li, Hong Yu, Lingfeng Kong, Shaojun Du
The calcifying shell is an excellent model for studying biomineralization and evolution. However, the molecular mechanisms of shell formation are only beginning to be elucidated in Mollusca. It is known that shell matrix proteins (SMPs) play important roles in shell formation. With increasing data of shell matrix proteomes from various species, we carried out a BLASTp bioinformatics analysis using the shell matrix proteome from Crassostrea gigas against 443 SMPs from nine other species. The highly conserved tyrosinase and chitin related proteins were identified in bivalve...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345259/the-role-of-complement-inhibitors-beyond-controlling-inflammation
#6
REVIEW
A M Blom
The complement system is an arm of innate immunity that aids in the removal of pathogens and dying cells. Due to its harmful, pro-inflammatory potential, complement is controlled by several soluble and membrane-bound inhibitors. This family of complement regulators has been recently extended by the discovery of several new members, and it is becoming apparent that these proteins harbour additional functions. In this review, the current state of knowledge of the physiological functions of four complement regulators will be described: cartilage oligomeric matrix protein (COMP), CUB and sushi multiple domains 1 (CSMD1), sushi domain-containing protein 4 (SUSD4) and CD59...
March 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28272991/risk-estimation-to-human-health-caused-by-the-mercury-content-of-sushi-and-sashimi-sold-in-japanese-restaurants-in-brazil
#7
Jeanne Clécia Alves, Esther Lima de Paiva, Raquel Fernanda Milani, Eduardo Bearzoti, Marcelo Antonio Morgano, Késia Diego Quintaes
Although fish is a healthy alternative for meat, it can be a vehicle for mercury (Hg), including in its most toxic organic form, methylmercury (MeHg). The objective of the present study was to estimate the risk to human health caused by the consumption of sushi and sashimi as commercialized by Japanese food restaurants in the city of Campinas (SP, Brazil). The total Hg content was determined by atomic absorption spectrometry with thermal decomposition and amalgamation, and the MeHg content calculated considering that 90% of the total Hg is in the organic form...
March 8, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28263345/group-b-streptococci-in-sushi-and-sashimi
#8
Tse Hsien Koh, Delphine Yh Cao, Boon Ching Khoo, Lan Huay Ong, Fionicca Teo, Terry Wp Tan
No abstract text is available yet for this article.
February 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28221849/restaurant-policies-and-practices-for-serving-raw-fish-in-minnesota
#9
Nicole Hedeen
The number of restaurants serving sushi within Minnesota is continuously increasing. The practices and protocols of serving raw fish are complex and require detailed planning to ensure that food served to patrons will not cause illness. Although the popularity of sushi is increasing, there is a lack of research on food safety issues pertaining to preparation of raw fish and sushi rice. To address this gap, the Minnesota Department of Health Environmental Health Specialists Network Food program collected descriptive data on restaurant practices and policies concerning the service of raw fish and sushi rice in 40 Minnesota restaurants...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28130869/proteomic-analysis-of-human-follicular-fluid-in-poor-ovarian-responders-during-in-vitro-fertilization
#10
Jae Won Oh, Seul Ki Kim, Kyung-Cho Cho, Min-Sik Kim, Chang Suk Suh, Jung Ryeol Lee, Kwang Pyo Kim
Poor ovarian response (POR) observed in controlled ovarian stimulation (COS) is often observed during in vitro fertilization and embryo transfer (IVF-ET) cycles and is a major problem. A POR has been found to be related to several factors, including advanced age, high body mass index, and history of ovarian or pelvic surgery. However, it is difficult to predict POR, as there are no specific biomarkers known. In this study, we used quantitative proteomic analyses to investigate potential biomarkers that can predict poor response during IVF based on follicular fluid samples...
January 28, 2017: Proteomics
https://www.readbyqxmd.com/read/28075039/using-dna-barcoding-to-track-seafood-mislabeling-in-los-angeles-restaurants
#11
Demian A Willette, Sara E Simmonds, Samantha H Cheng, Sofia Esteves, Tonya L Kane, Hayley Nuetzel, Nicholas Pilaud, Rita Rachmawati, Paul H Barber
Seafood mislabeling is common in both domestic and international markets. Studies on seafood fraud often report high rates of mislabeling (e.g., >70%), but these studies have been limited to a single sampling year, which means it is difficult to assess the impact of stricter governmental truth-in-labeling regulations. We used DNA barcoding to assess seafood labeling in 26 sushi restaurants in Los Angeles over 4 years. Seafood from 3 high-end grocery stores were also sampled (n = 16) in 2014. We ordered 9 common sushi fish from menus, preserved tissue samples in 95% ethanol, extracted the genomic DNA, amplified and sequenced a portion of the mtDNA COI gene, and identified the resulting sequence to known fish sequences from the National Center for Biotechnology Information nucleotide database...
January 11, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28070635/incidence-of-three-kudoa-spp-k-neothunni-k-hexapunctata-and-k-thunni-myxosporea-multivalvulida-in-thunnus-tunas-distributed-in-the-western-pacific-ocean
#12
Akihiro Kasai, Hideaki Tsuduki, Lea Angsinco Jimenez, Ying-Chun Li, Shuhei Tanaka, Hiroshi Sato
A variety of tunas of the genus Thunnus are consumed daily in Japan as sliced raw fish (sashimi and sushi). The consumption of fresh sliced raw fish, i.e., unfrozen or uncooked, can sometimes cause food poisoning that is manifested by transient diarrhea and vomiting for a single day. One of the causes of this type of food poisoning has been identified as live Kudoa septempunctata (Myxosporea: Multivalvulida) in the olive flounder (Paralichthys olivaceus). Furthermore, raw slices of fresh tunas are highly suspected to be a possible causative fish of similar food poisoning in Japan...
January 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28034367/dendritic-trafficking-faces-physiologically-critical-speed-precision-tradeoffs
#13
Alex H Williams, Cian O'Donnell, Terrence J Sejnowski, Timothy O'Leary
Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model of neuron-wide transport, sometimes called the 'sushi-belt model' (Doyle and Kiebler, 2011). Current theories and experiments are based on this model, yet its predictions are not rigorously understood. We formalized the sushi belt model mathematically, and show that it can achieve arbitrarily complex spatial distributions of cargo in reconstructed morphologies...
December 30, 2016: ELife
https://www.readbyqxmd.com/read/27924249/gastrointestinal-anisakidosis-watch-what-you-eat
#14
Moiz Ahmed, Faez Ayoob, Mayurathan Kesavan, Vivek Gumaste, Ambreen Khalil
Gastrointestinal anisakidosis is an under-reported and often misdiagnosed parasitic infection caused by the larvae of a nematode anisakis. The majority of cases are seen in Japan due to the consumption of raw and undercooked seafood; however, the incidence is likely to rise in the United States given the rising popularity of Japanese cuisine like sashimi or sushi. This unique report highlights the importance of considering anisakiasis in the differential diagnoses for patients with nonspecific abdominal symptoms with a recent history of raw or undercooked fish consumption...
November 2, 2016: Curēus
https://www.readbyqxmd.com/read/27918551/hepatocarcinogenesis-in-transgenic-mice-carrying-hepatitis-b-virus-pre-s-s-gene-with-the-sw172-mutation
#15
M-W Lai, K-H Liang, W-R Lin, Y-H Huang, S-F Huang, T-C Chen, C-T Yeh
Hepatitis B virus (HBV) carrying the rtA181T/sW172* mutation conferred cross-resistance to adefovir and lamivudine. Cell-based and clinical studies indicated that HBV carrying this mutation had an increased oncogenic potential. Herein, we created transgenic mouse models to study the oncogenicity of the HBV pre-S/S gene containing this mutation. Transgenic mice were generated by transfer of the HBV pre-S/S gene together with its own promoter into C57B6 mice. Four lines of mice were created. Two of them carried wild-type gene and produced high and low levels of HBV surface antigen (HBsAg) (TgWT-H and L)...
December 5, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27775699/susd2-expression-in-high-grade-serous-ovarian-cancer-correlates-with-increased-patient-survival-and-defective-mesothelial-clearance
#16
J N Sheets, M Iwanicki, J F Liu, B E Howitt, M S Hirsch, J A A Gubbels, R Drapkin, K A Egland
The cause of death among the majority of epithelial ovarian cancer (EOC) patients involves passive dissemination of cancer cells within the peritoneal cavity and subsequent implantation of cancer spheroids into adjacent organs. Thus, it is important to identify the factors that mediate EOC metastasis and implantation, including clearance of the mesothelium. Sushi domain containing 2 (SUSD2) encodes a type I transmembrane protein containing several functional domains inherent to adhesion molecules. Immunohistochemical analysis determined the presence of SUSD2 in several subtypes of EOC, with the strongest staining observed in high-grade serous ovarian carcinomas (HGSOCs)...
October 24, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27764775/complement-inhibitor-csmd1-acts-as-tumor-suppressor-in-human-breast-cancer
#17
Astrid Escudero-Esparza, Michael Bartoschek, Chrysostomi Gialeli, Marcin Okroj, Sioned Owen, Karin Jirström, Akira Orimo, Wen G Jiang, Kristian Pietras, Anna M Blom
Human CUB and Sushi multiple domains 1 (CSMD1) is a membrane-bound complement inhibitor suggested to act as a putative tumor suppressor gene, since allelic loss of this region encompassing 8p23 including CSMD1 characterizes various malignancies. Here, we assessed the role of CSMD1 as a tumor suppressor gene in the development of breast cancer in vitro and in vivo. We found that human breast tumor tissues expressed CSMD1 at lower levels compared to that in normal mammary tissues. The decreased expression of CSMD1 was linked to a shorter overall survival of breast cancer patients...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27756250/mir-10b-exerts-oncogenic-activity-in-human-hepatocellular-carcinoma-cells-by-targeting-expression-of-cub-and-sushi-multiple-domains-1-csmd1
#18
Qiao Zhu, Li Gong, Jun Wang, Qian Tu, Li Yao, Jia-Rui Zhang, Xiu-Juan Han, Shao-Jun Zhu, Shu-Mei Wang, Yan-Hong Li, Wei Zhang
BACKGROUND: Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This study assessed expression and the oncogenic activity of miRNA-10b (miR-10b) in HCC. METHODS: Forty-five paired human HCC and adjacent non-tumor tissues were collected for qRT-PCR and immunohistochemistry analysis of miR-10b and CUB and Sushi multiple domains 1 (CSMD1), respectively...
October 18, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27650494/a-novel-fusion-of-alt-803-interleukin-il-15-superagonist-with-an-antibody-demonstrates-antigen-specific-antitumor-responses
#19
Bai Liu, Lin Kong, Kaiping Han, Hao Hong, Warren D Marcus, Xiaoyue Chen, Emily K Jeng, Sarah Alter, Xiaoyun Zhu, Mark P Rubinstein, Sixiang Shi, Peter R Rhode, Weibo Cai, Hing C Wong
IL-15 and its receptor α (IL-15Rα) are co-expressed on antigen-presenting cells, allowing transpresentation of IL-15 to immune cells bearing IL-2RβγC and stimulation of effector immune responses. We reported previously that the high-affinity interactions between an IL-15 superagonist (IL-15N72D) and the extracellular IL-15Rα sushi domain (IL-15RαSu) could be exploited to create a functional scaffold for the design of multivalent disease-targeted complexes. The IL-15N72D·IL-15RαSuFc complex, also known as ALT-803, is a multimeric complex constructed by fusing IL-15N72D·IL-15RαSu to the Fc domain of IgG1...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27595206/mycobacterium-marinum-skin-infection-in-a-sushi-cook
#20
Stefano Veraldi, Ermira Çuka, Fabrizio Vaira, Gianluca Nazzaro
No abstract text is available yet for this article.
October 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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