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https://www.readbyqxmd.com/read/29769573/discovery-of-a-novel-il-15-based-protein-with-improved-developability-and-efficacy-for-cancer-immunotherapy
#1
Qiyue Hu, Xin Ye, Xiangdong Qu, Dongbing Cui, Lei Zhang, Zhibin Xu, Hong Wan, Lianshan Zhang, Weikang Tao
Interleukin-15 (IL-15) can promote both innate and adaptive immune reactions by stimulating CD8+ /CD4+ T cells and natural killer cells (NK) while showing no effect in activating T-regulatory (Treg) cells or inducing activation-associated death among effector T cells and NK cells. Thus, IL-15 is considered as one of the most promising molecules for antitumor immune therapy. To improve the drug-like properties of natural IL-15, we create an IL-15-based molecule, named P22339, with the following characteristics: 1) building a complex of IL-15 and the Sushi domain of IL-15 receptor α chain to enhance the agonist activity of IL-15 via transpresentation; 2) through a rational structure-based design, creating a disulfide bond linking the IL-15/Sushi domain complex with an IgG1 Fc to augment its half-life...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29723377/gnathostomiasis-an-emerging-infectious-disease-relevant-to-all-dermatologists
#2
Francisco Bravo, Bernardo Gontijo
Gnathostomiasis is a parasitic infection caused by the third larval stage of nematodes of the genus Gnathostoma. The disease is endemic in some countries around the world. In the American continent, the majority of cases is concentrated in Mexico, Ecuador, and Peru. However, due to increasing traveling either at the intercontinental or intracontinental level, the disease is seen each time more frequently in tourists. Furthermore, countries, such as Brazil, that have never been considered endemic are reporting autochthonous cases...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29716661/detection-of-ascaridoid-nematode-parasites-in-the-important-marine-food-fish-conger-myriaster-brevoort-anguilliformes-congridae-from-the-zhoushan-fishery-china
#3
Hui-Xia Chen, Lu-Ping Zhang, David I Gibson, Liang Lü, Zhen Xu, Hai-Tao Li, Hui-Dong Ju, Liang Li
BACKGROUND: The whitespotted conger Conger myriaster (Brevoort) (Anguilliformes: Congridae) is an extremely marketable food fish, commonly consumed as sashimi or sushi in some Asian countries (i.e. Japan, Korea and China). Conger myriaster is also suspected as being an extremely important source of human anisakidosis. However, there is currently very little information on the levels of infection with ascaridoid nematode parasites in this economically important marine fish. The aims of the present study are to determine the species composition, prevalence and mean intensity of ascaridoid parasites of C...
May 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29679892/electric-field-driven-assembly-of-live-bacterial-cell-microarrays-for-rapid-phenotypic-assessment-and-cell-viability-testing
#4
Meenal Goel, Abhishek Verma, Shalini Gupta
Microarray technology to isolate living cells using external fields is a facile way to do phenotypic analysis at the cellular level. We have used alternating current dielectrophoresis (AC-DEP) to drive the assembly of live pathogenic Salmonella typhi (S.typhi) and Escherichia coli (E.coli) bacteria into miniaturized single cell microarrays. The effects of voltage and frequency were optimized to identify the conditions for maximum cell capture which gave an entrapment efficiency of 90% in 60 min. The chip was used for calibration-free estimation of cellular loads in binary mixtures and further applied for rapid and enhanced testing of cell viability in the presence of drug via impedance spectroscopy...
April 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29673434/diphyllobothriasis-in-a-u-s-military-aviator
#5
Stephen D Kasteler
BACKGROUND: Diphyllobothriasis is estimated to afflict 10-20 million people worldwide; however, this is the first case reported in a United States military aviator. Among the largest parasites of humans, the "fish tapeworm" grows from 2-15 m in length, can live >20 yr in the intestines, and is contracted through consumption of uncooked, unfrozen freshwater or anadromous fish species. CASE REPORT: A 32-yr-old male F-22 pilot presented with mild stomach cramping, bloating, nausea, and intermittent loose stools...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29663392/sushi-repeat-containing-protein-x-linked-2-a-novel-phylogenetically-conserved-hypothalamo-pituitary-protein
#6
Mehwish Anwer, Tamuna Bolkvadze, Xavier Ekolle Ndode-Ekane, Noora Puhakka, Tuomas Rauramaa, Ville Leinonen, Erwin A van Vliet, Dick F Swaab, Annakaisa Haapasalo, Stina Leskelä, Nea Bister, Tarja Malm, Synnöve Carlson, Eleonora Aronica, Asla Pitkänen
Sushi repeat-containing protein X-linked 2 (SRPX2) is a novel protein associated with language development, synaptic plasticity, tissue remodeling, and angiogenesis. We investigated the expression and spatial localization of SRPX2 in normal mouse, rat, monkey, and human brain using in situ hybridization and immunohistochemistry. Antibody specificity was determined using in vitro siRNA based silencing of SRPX2. Cell type-specific expression was verified by double-labeling with oxytocin or vasopressin. Western blot was used to detect SRPX2 protein in rat and human plasma and cerebrospinal fluid...
April 16, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29607219/lactic-acid-bacteria-isolated-from-japanese-fermented-fish-funa-sushi-inhibit-mesangial-proliferative-glomerulonephritis-by-alcohol-intake-with-stress
#7
Yumiko Yamada, Masumi Endou, Shunichi Morikawa, Jun Shima, Noriko Komatshzaki
The aim of this study was to examine the effect of heat-killed Lactobacillus paracasei NFRI 7415 on kidney and bone in mice fed an ethanol-containing diet with stress. Eight-week-old Cril  :  CD1 mice were fed a control diet (CD), an alcohol diet (AD) (35.8% of total energy from ethanol), or an alcohol diet containing 20% heat-killed Lb. paracasei NFRI 7415 (107  CFU/g) (LD) for 4 weeks. Mice in the AD and LD groups also underwent restraint stress for two weeks from 13 days. The mice were placed in a 50 mL plastic tube, which had a small hole drilled around its base to allow ventilation, and restrained for 1 h every day...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29575998/human-endometrial-reconstitution-from-somatic-stem-cells-the-importance-of-niche-like-cells
#8
Nuria López-Pérez, Claudia Gil-Sanchis, Hortensia Ferrero, Amparo Faus, Ana Díaz, Antonio Pellicer, Irene Cervelló, Carlos Simón
Endometrial regeneration has long been proposed to be mediated by stem cells, but the isolation of endometrial stem cells has been hampered by a lack of validated markers. Specific markers would enable isolation of these stem cells, thereby promoting advancements in regenerative medicine for the treatment of endometrial diseases and dysfunctions. We sought to investigate the regenerative ability of human endometrial positive for sushi domain containing 2/intercellular adhesion molecule 1 (SUSD2+ /ICAM1+ ) cells and Side Population cell lines in a xenograft mice model...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29538362/surgical-necrotizing-enterocolitis-in-extremely-premature-neonates-is-associated-with-genetic-variations-in-an-intergenic-region-of-chromosome-eight
#9
Tamas Jilling, Namasivayam Ambalavanan, C Michael Cotten, Colin A Martin, Akhil Maheshwari, Kurt Schibler, Joshua Levy, Grier P Page
BACKGROUND: Twin studies suggest that genetic factors may account for up to 50% increased risk for necrotizing enterocolitis (NEC), but genome-wide association studies (GWAS) for NEC are lacking. METHODS: Genotyping was done on Illumina BeadChip, followed by analysis using PLINK with logistic regression under an additive model. RESULTS: Among 751 extremely low birth weight (<1000 g, >401 g) neonates, 30 had surgical NEC. 261 single nucleotide polymorphisms (SNPs) showed association with NEC at P<0...
March 14, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29534103/prevalence-and-correlates-of-persistent-intracellular-hiv-transcription-in-individuals-on-efavirenz-versus-atazanavir-based-regimens-a-prospective-cohort-study
#10
Dimitrios Pilalas, Lemonia Skoura, Apostolia Margariti, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Olga Tsachouridou, Pantelis Zebekakis, Simeon Metallidis, Maria Papaioannou
OBJECTIVES: Despite successful virological suppression, HIV transcription frequently persists intracellularly. In this study, we hypothesize that HIV persistent transcription(HIVpt) may affect to a different extent patients on stable efavirenz(EFV) versus atazanavir(ATV)-based regimens. The role of the expression of drug efflux transporters in HIVpt was also investigated. METHODS: We prospectively enrolled 51 virologically suppressed patients on first-line treatment for one year with EFV or ATV combined with emtricitabine and tenofovir and followed them up for one year...
2018: PloS One
https://www.readbyqxmd.com/read/29511442/srpx2-regulates-colon-cancer-cell-metabolism-by-mir-192-215-via-pi3k-akt
#11
Jian Zhao, Jian Xu, Rui Zhang
Colon cancer is one of common cancer in the world and glycolysis is one of the major problems in colon cancer therapy. MicroRNAs (miRNAs) involve in colon cancer progression. Sushi repeat-containing protein X-linked 2 (SRPX2) is associated with poor prognosis in some cancer patients, however, the role of SRPX2 including glycolytic metabolism regulated by miRNAs is unclear in colon cancer. So, the purpose of the present study is to elucidate the underlying mechanism in colon cancer metabolism mediated by SRPX2...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29503071/a-young-man-with-acute-onset-epigastric-pain-after-the-ingestion-of-japanese-sushi
#12
Yusaku Kajihara
No abstract text is available yet for this article.
March 1, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29474910/super-resolution-imaging-of-the-extracellular-space-in-living-brain-tissue
#13
Jan Tønnesen, V V G Krishna Inavalli, U Valentin Nägerl
The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED microscopy and fluorescent labeling of the extracellular fluid to develop super-resolution shadow imaging (SUSHI) of brain ECS in living organotypic brain slices. SUSHI enables quantitative analysis of ECS structure and reveals dynamics on multiple scales in response to a variety of physiological stimuli...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29452720/evaluation-of-the-biological-activities-of-the-il-15-superagonist-complex-alt-803-following-intravenous-versus-subcutaneous-administration-in-murine-models
#14
Bai Liu, Monica Jones, Lin Kong, Terra Noel, Emily K Jeng, Sixiang Shi, Christopher G England, Sarah Alter, Jeffrey S Miller, Weibo Cai, Peter R Rhode, Hing C Wong
ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8+ T cell proliferation and activation, and effectively promoting potent anti-tumor responses. Currently, ALT-803 is in clinical trials for treatment of various solid tumors and hematological malignancies. In the initial phase of these clinical studies, intravenous (iv) injection was used according to the route used in pre-clinical efficacy studies...
July 2018: Cytokine
https://www.readbyqxmd.com/read/29421362/increased-exposure-to-extended-spectrum-%C3%AE-lactamase-producing-multidrug-resistant-enterobacteriaceae-through-the-consumption-of-chicken-and-sushi-products
#15
Ana Isabel Vitas, Dixita Naik, Lara Pérez-Etayo, David González
The aim of this study was to determine the occurrence and patterns of resistance of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food products purchased in Navarra, northern Spain. A total of 174 samples of fish and chicken were analyzed from September 2015 to September 2016, including raw and ready-to-eat products: trout (n = 25), salmon (n = 28), panga (n = 13), chicken nuggets and chicken scalopes (n = 32), sushi (n = 31) and sliced cooked poultry (n = 45)...
March 23, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29376485/genome-wide-oxidative-bisulfite-sequencing-identifies-sex-specific-methylation-differences-in-the-human-placenta
#16
Sungsam Gong, Michelle D Johnson, Justyna Dopierala, Francesca Gaccioli, Ulla Sovio, Miguel Constância, Gordon Cs Smith, D Stephen Charnock-Jones
DNA methylation is an important regulator of gene function. Fetal sex is associated with the risk of several specific pregnancy complications related to placental function. However, the association between fetal sex and placental DNA methylation remains poorly understood. We carried out whole-genome oxidative bisulfite sequencing in the placentas of two healthy female and two healthy male pregnancies generating an average genome depth of coverage of 25x. Most highly ranked differentially methylated regions (DMRs) were located on the X chromosome but we identified a 225 kb sex-specific DMR in the body of the CUB and Sushi Multiple Domains 1 (CSMD1) gene on chromosome 8...
February 21, 2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29348232/a-self-assembled-nanoscale-robotic-arm-controlled-by-electric-fields
#17
Enzo Kopperger, Jonathan List, Sushi Madhira, Florian Rothfischer, Don C Lamb, Friedrich C Simmel
The use of dynamic, self-assembled DNA nanostructures in the context of nanorobotics requires fast and reliable actuation mechanisms. We therefore created a 55-nanometer-by-55-nanometer DNA-based molecular platform with an integrated robotic arm of length 25 nanometers, which can be extended to more than 400 nanometers and actuated with externally applied electrical fields. Precise, computer-controlled switching of the arm between arbitrary positions on the platform can be achieved within milliseconds, as demonstrated with single-pair Förster resonance energy transfer experiments and fluorescence microscopy...
January 19, 2018: Science
https://www.readbyqxmd.com/read/29342096/high-resolution-lipidomics-of-the-early-life-stages-of-the-red-seaweed-porphyra-dioica
#18
Elisabete da Costa, Vitor Azevedo, Tânia Melo, Andreia M Rego, Dmitry V Evtuguin, Pedro Domingues, Ricardo Calado, Rui Pereira, Maria H Abreu, Maria R Domingues
Porphyra dioica is a commercial seaweed consumed all over the world, mostly in the shape of nori sheets used for "sushi" preparation. It is a well-known part of the Asian diet with health benefits, which have been associated, among others, to the high levels of n-3 and n-6 fatty acids in this red alga. However, other highly valued lipids of Porphyra are polar lipids that remain largely undescribed and can have both nutritional value and bioactivity, thus could contribute to the valorization of this seaweed...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29279440/detection-of-anisakid-larvae-in-marinated-mackerel-sushi-in-tokyo-japan
#19
Toshihiro Tokiwa, Yuya Kobayashi, Kazunori Ike, Yasuyuki Morishima, Hiromu Sugiyama
No abstract text is available yet for this article.
January 23, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29244816/treatment-with-albumin-hydroxyoleic-acid-complex-restores-sensorimotor-function-in-rats-with-spinal-cord-injury-efficacy-and-gene-expression-regulation
#20
Gerardo Avila-Martin, Manuel Mata-Roig, Iriana Galán-Arriero, Julian S Taylor, Xavier Busquets, Pablo V Escribá
Sensorimotor dysfunction following incomplete spinal cord injury (SCI) is often characterized by paralysis, spasticity and pain. Previously, we showed that intrathecal (i.t.) administration of the albumin-oleic acid (A-OA) complex in rats with SCI produced partial improvement of these symptoms and that oral 2-hydroxyoleic acid (HOA, a non-hydrolyzable OA analogue), was efficacious in the modulation and treatment of nociception and pain-related anxiety, respectively. Here we observed that intrathecal treatment with the complex albumin-HOA (A-HOA) every 3 days following T9 spinal contusion injury improved locomotor function assessed with the Rotarod and inhibited TA noxious reflex activity in Wistar rats...
2017: PloS One
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