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https://www.readbyqxmd.com/read/29151830/antihypertensive-properties-of-tilapia-oreochromis-spp-frame-and-skin-enzymatic-protein-hydrolysates
#1
Hsin-Chieh Lin, Adeola M Alashi, Rotimi E Aluko, Bonnie Sun Pan, Yu-Wei Chang
Proteins from tilapia frame and skin can potentially be precursors of antihypertensive peptides according to the result of BIOPEP analyses. The aim was to generate peptides with inhibitory effects against angiotensin-converting enzyme (ACE) and renin from tilapia frame and skin protein isolates (FPI and SPI). The most active hydrolysate was then tested for blood pressure-lowering ability in spontaneously hypertensive rats (SHRs). Tilapia frame and skin protein hydrolysates (FPHs and SPHs) were respectively produced from FPI and SPI hydrolysis using pepsin, papain, or bromelain...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29128226/camel-milk-protein-hydrolysates-with-improved-technofunctional-properties-and-enhanced-antioxidant-potential-in-in-vitro-and-in-food-model-systems
#2
Kholoud Awad Al-Shamsi, Priti Mudgil, Hassan Mohamed Hassan, Sajid Maqsood
Camel milk protein hydrolysates (CMPH) were generated using proteolytic enzymes, such as alcalase, bromelain, and papain, to explore the effect on the technofunctional properties and antioxidant potential under in vitro and in real food model systems. Characterization of the CMPH via degree of hydrolysis, sodium dodecyl sulfate-PAGE, and HPLC revealed that different proteins in camel milk underwent degradation at different degrees after enzymatic hydrolysis using 3 different enzymes for 2, 4, and 6 h, with papain displaying the highest degradation...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29102407/physical-and-kinematic-properties-of-cryopreserved-camel-sperm-after-elimination-of-semen-viscosity-by-different-techniques
#3
Khalid El-Bahrawy, Sherif Rateb, Marwa Khalifa, Davide Monaco, Giovanni Lacalandra
This investigation aimed to determine the influence of using different techniques for liquefaction of semen on post-thaw physical and dynamic characteristics of camel spermatozoa. A total of 144 ejaculates were collected from 3 adult camels, Camelus dromedarius, twice-weekly over 3 consecutive breeding seasons. A raw aliquot of each ejaculate was evaluated for physical and morphological properties, whereas the remaining portion was diluted (1:3) with glycerolated Tris lactose egg yolk extender, and was further subjected to one of the following liquefaction treatments: control (untreated), 5μl/ml α-amylase, 0...
October 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29081621/penetration-of-bromelain-in-serum-and-rhinosinusal-mucosa-in-patients-undergoing-endoscopic-sinus-surgery
#4
Desiderio Passali, Luisa Maria Bellussi, Codrut Sarafoleanu, Michele Loglisci, Claudiu Manea, Cristina Iosif, Francesco Maria Passali
No abstract text is available yet for this article.
July 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29080507/mucus-permeating-self-emulsifying-drug-delivery-systems-sedds-about-the-impact-of-mucolytic-enzymes
#5
Nuri Ari Efiana, Thi Nhu Quynh Phan, Arko Jatmiko Wicaksono, Andreas Bernkop-Schnürch
This study aimed to improve the mucus permeating properties of self-emulsifying drug delivery systems (SEDDS) by anchoring lipidized bromelain, papain and trypsin using palmitoyl chloride. SEDDS containing enzyme-palmitate conjugates were characterized regarding droplet size and zeta potential. Their mucus permeating properties were evaluated by Transwell diffusion and rotating tube method using fluorescein diacetate (FDA) as marker. Degree of substitution of modified enzymes was 35.3%, 47.8% and 38.5% for bromelain-palmitate, papain-palmitate and trypsin-palmitate, respectively...
October 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29079537/enzyme-decorated-drug-carriers-targeted-swords-to-cleave-and-overcome-the-mucus-barrier
#6
Claudia Menzel, Andreas Bernkop-Schnürch
The use of mucus permeating drug carrier systems being able to overcome the mucus barrier can lead to a remarkable enhancement in bioavailability. One promising approach is the design of mucolytic enzyme decorated carrier systems (MECS). These systems include micro- and nanoparticles as well as self-emulsifying drug delivery systems (SEDDS) decorated with mucin cleaving enzymes such as papain (PAP) or bromelain (BRO). MECS are able to cross the mucus barrier in a comparatively efficient manner by cleaving mucus substructures in front of them on their way to the epithelium...
October 24, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29068048/possibilities-for-developing-texture-modified-beef-steaks-suitable-for-older-consumers-using-fruit-derived-proteolytic-enzymes
#7
Cristina Botinestean, Carolina Gomez, Yingqun Nian, Mark A E Auty, Joseph P Kerry, Ruth M Hamill
Meat intakes in the older population are commonly reduced because the relatively tough texture of meat can impair mastication. Fruit-derived proteolytic enzymes have been reported to have beneficial effects on tenderness, by causing significant degradation of myofibrillar proteins and collagen. Three treatments including: papain, bromelain and a 50:50 mixture of papain/bromelain, alongside one control were applied to beef M. semitendinosus steaks. Effects on Warner - Bratzler shear force, texture parameters, color, and cook loss were determined...
October 25, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/29033046/eschar-removal-by-bromelain-based-enzymatic-debridement-nexobrid-%C3%A2-in-burns-an-european-consensus
#8
Christoph Hirche, Antonella Citterio, Henk Hoeksema, Ján Koller, Martina Lehner, José Ramón Martinez, Stan Monstrey, Alexandra Murray, Jan A Plock, Frank Sander, Alexandra Schulz, Benjamin Ziegler, Ulrich Kneser
Early debridement and/or eschar removal is regarded as a significant step in the treatment of deep partial and full thickness burns. It aims to control wound bioburden and allows early wound closure by conservative treatment or skin grafting. Preservation of viable dermis accompanied by early wound closure, is regarded as a necessary step to reduce scar related complication, e.g. functional limitations and/or unaesthetic scar formation. Aside from the classical techniques of surgical excision as tangential excision for eschar removal, hydro-surgery, maggot therapy, laser, enzymatic debridement have been described as additional techniques in the burn surgeon's armamentarium...
October 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29028858/approach-to-the-mature-cosmetic-patient-aging-gracefully
#9
Susan Weinkle, Michael Saco
<p>Aging gracefully has taken on a whole new meaning over the past few decades as new aesthetic treatments have been developed and are becoming more sophisticated by the day. The aging process, which is exacerbated by chronic UV exposure, results in dyspigmentation, loss of skin laxity, precancerous and cancerous skin lesions, fat loss and redistribution, and bone resorption. Laser and light devices can be used to treat dyspigmentation, while neuromodulators and soft tissue fillers can be used for rhytides and revolumization...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29027934/angiotensin-i-converting-enzyme-ace-inhibitory-activity-antioxidant-properties-phenolic-content-and-amino-acid-profiles-of-fucus-spiralis-l-protein-hydrolysate-fractions
#10
Lisete Paiva, Elisabete Lima, Ana Isabel Neto, José Baptista
Food protein-derived hydrolysates with multi-bioactivities such as antihypertensive and antioxidant properties have recently received special attention since both activities can play significant roles in preventing cardiovascular diseases. This study reports, for the first time, the angiotensin I-converting enzyme (ACE)-inhibition and antioxidant properties of ultrafiltrate fractions (UF) with different molecular weight ranges (<1, 1-3 and ≥3 kDa) obtained from Fucus spiralis protein hydrolysate (FSPH) digested with cellulase-bromelain...
October 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29022979/the-antibacterial-and-antibiofilm-efficacies-of-a-liposomal-peptide-originating-from-rice-bran-protein-against-listeria-monocytogenes
#11
Chuanfen Pu, Wenting Tang
With the aim of exploring a natural antilisterial peptide from food-derived origin, an antibacterial peptide named as Alpep7 was purified from the bromelain hydrolysate of rice bran protein (RBP) in this study. The resulting amino acid consequence was identified as KVDHFPL (Lys-Val-Asp-His-Phe-Pro-Leu) by ultraperformance liquid chromatography tandem matrix-assisted laser desorption/ionisation quadrupole time-of-flight mass spectrometry (MALDI Q-TOF MS). In addition, to assess the probability of the targeted delivery of liposome encapsulation of the peptide to Listeria biofilm, Alpep7-loaded liposomes were further prepared from a mixture of dipalmitoylphosphatidylcholine, stearylamine and cholesterol in a molar ratio of 10 : 3 : 2 and characterised by the analysis of particle size, zeta potential, microtopography and storage stability...
October 12, 2017: Food & Function
https://www.readbyqxmd.com/read/28942160/gold-nanoconjugates-reinforce-the-potency-of-conjugated-cisplatin-and-doxorubicin
#12
Sana Iram, Manaal Zahera, Salman Khan, Imran Khan, Asad Syed, Abu Ayoobul Ansary, Fuad Ameen, Omar H M Shair, Mohd Sajid Khan
Osteosarcoma or osteogenic sarcoma is the most common and prevalent cancerous tumor of bone and occurs especially in children and teens. Recent treatment strategy includes a combination of both chemotherapy and surgeries. Although, the use of single drug-based chemotherapy treatment remains unsatisfactory. Therefore, combinatorial therapy has emerged as a potential strategy for treatment with limited side- effects. Here, we evaluated the combinatorial anticancerous effect of cisplatin (CIS) and doxorubicin (DOX) bioconjugated bromelain encapsulated gold nanoparticles (B-AuNPs conjugated CIS and DOX) in the treatment of osteosarcoma...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28917871/inhibition-of-gelatinized-rice-starch-retrogradation-by-rice-bran-protein-hydrolysates
#13
Liya Niu, Leiyan Wu, Jianhui Xiao
The retrogradation of gelatinized rice starch (GRS) during the shelf life of a product is the biggest barrier related to starch-containing foods. The objective of this study was to produce rice bran protein hydrolysate (RBPH) using proteolytic enzymes (alcalase, flavourzyme, protamex, neutrase, bromelain, papain and trypsin) to suppress the retrogradation of GRS and understand the physical phenomena underlying the reduced retrogradation of GRS by RBPH during short- and long-term storage. Mixtures of GRS incorporated with Protamex-hydrolyzed rice bran protein at 1h (PRBPH-1) at a degree of hydrolysis of 15...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28887189/fluorescence-spectroscopic-analysis-of-the-interaction-of-papain-and-bromelain-with-l-ascorbic-acid-%C3%AE-tocopherol-%C3%AE-carotene-and-astaxanthin
#14
Xiangrong Li, Zhenhua Yang, Yulin Bai
In this study, the interaction between four classic dietary antioxidants (including L-ascorbic acid, α-tocopherol, β-carotene and astaxanthin) and papain/bromelain was investigated by fluorescence spectroscopy. The results show that the quenching mechanisms are all static quenching at lower concentrations of antioxidants, but at higher concentrations of antioxidants, predominantly by the "sphere of action" quenching mechanisms. The binding processes of the four antioxidants to papain/bromelain are all synergistically driven by enthalpy and entropy, and the major driving forces are electrostatic effect and hydrophobic interactions...
September 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28864390/protease-functionalized-mucus-penetrating-microparticles-in-vivo-evidence-for-their-potential
#15
Arshad Mahmood, Flavia Laffleur, Gintare Leonaviciute, Andreas Bernkop-Schnürch
The focus of the current study was to explore whether immobilization of proteases to microparticles could result in their enhanced penetration into mucus. The proteases papain (PAP) and bromelain (BROM) were covalently attached to a polyacrylate (PAA; Carbopol 971P) via amide bond formation based on carbodiimide reaction. Microparticles containing these conjugates were generated via ionic gelation with calcium chloride and were characterized regarding size, surface charge, enzymatic activity and fluorescein diacetate (FDA) loading efficiency...
August 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28822027/impact-of-orientation-and-flexibility-of-peptide-linkers-on-t-maritima-lipase-tm1350-displayed-on-bacillus-subtilis-spores-surface-using-cotb-as-fusion-partner
#16
Jawad Ullah, Huayou Chen, Ake Vastermark, Jinru Jia, Bangguo Wu, Zhong Ni, Yilin Le, Hongcheng Wang
Fusion protein construction often requires peptide linkers for prolonged conformation, extended stability and enzyme activity. In this study a series of fusion between Thermotoga maritima lipase Tm1350 and Bacillus subtillis coat protein CotB, comprising of several peptide linkers, with different length, flexibility and orientations were constructed. Effects of temperature, pH and chemicals were examined, on the activity of displayed enzyme. The fusion protein with longer flexible linkers L9 [(GGGGS)4] and L7 (GGGGS-GGGGS-EAAAK-EAAAK-GGGGS-GGGGS) possess 1...
August 18, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28764284/efficacy-of-bromelain-along-with-trypsin-rutoside-trihydrate-enzymes-and-diclofenac-sodium-combination-therapy-for-the-treatment-of-tmj-osteoarthritis-a-randomised-clinical-trial
#17
S Jayachandran, Priyanka Khobre
INTRODUCTION: Osteoarthritis (OA) is a degenerative disorder characterized by chronic inflammatory response of cartilage and articular surface involving Temporomandibular Joint (TMJ). Pain as one of the major symptom of osteoarthritis affects the quality of life and is usually managed by Non Steroidal Anti Inflammatory Drugs (NSAIDs) such as diclofenac sodium. Bromelain, trypsin and rutoside trihydrate formulation can be used to treat this disease because of anti-inflammatory and anti-oxidant effects...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28734166/naturally-occurring-immunomodulators-with-antitumor-activity-an-insight-on-their-mechanisms-of-action
#18
REVIEW
Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque
Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities...
September 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28716747/cysteine-as-a-potential-anti-amyloidogenic-agent-with-protective-ability-against-amyloid-induced-cytotoxicity
#19
Masihuz Zaman, Syed Mohammad Zakariya, Saima Nusrat, Tajalli Ilm Chandel, Syed Musthapa Meeran, Mohammad Rehan Ajmal, Parvez Alam, Wahiduzzaman, Rizwan Hasan Khan
Protein aggregation and misfolding have been allied with numerous human disorders and thus inhibition of such occurrence has been center for intense research efforts against these diseases. Here, we investigated anti-fibrillation activity of cysteine and its effect on kinetics of stem bromelain amyloid fibril formation. We established the anti-fibrillation and anti aggregation activities of cysteine by using multiple approaches like turbidity measurements, dye binding assays (ThT and ANS) and structural changes were monitored by circular dichroism (CD) followed by electron microscopy...
December 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28706952/development-of-an-economical-method-to-reduce-the-extractable-latex-protein-levels-in-finished-dipped-rubber-products
#20
Ambegoda Liyanage Harini Amalka Perera, Bulathsinhalage Gayani Kanchana Perera
Natural rubber latex (NRL) allergy is caused by the extractable latex proteins in dipped rubber products. It is a major concern for the consumers who are sensitive to the allergenic extractable proteins (EP) in products such as NRL gloves. Objective of this research was to develop an economical method to reduce the EP in finished dipped NRL products. In order to reduce the EP levels, two natural proteases, bromelain from pineapple and papain from papaya, were extracted and partially purified using (NH4)2SO4...
2017: BioMed Research International
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