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https://www.readbyqxmd.com/read/29031157/a-european-multi-centre-external-quality-assessment-eqa-study-on-phenotypic-and-genotypic-methods-used-for-herpes-simplex-virus-hsv-drug-resistance-testing
#1
Baharak Afshar, David F Bibby, Renata Piorkowska, Natasha Ohemeng-Kumi, Robert Snoeck, Graciela Andrei, Sarah Gillemot, Florence Morfin, Emilie Frobert, Sonia Burrel, David Boutolleau, Brendan Crowley, Jean L Mbisa
BACKGROUND: Herpes Simplex Virus (HSV) drug resistance is a significant public health concern among immunocompromised individuals. Phenotypic assays are considered the gold standard method for detecting HSV drug resistance. However, plaque reduction assays (PRAs) are technically demanding, often with long turnaround times of up to four weeks. In contrast, genotypic tests can be performed within a few days. OBJECTIVES: The development and coordination of the first European External Quality Assessment (EQA) study to evaluate phenotypic and genotypic methods used for HSV drug resistance testing in specialised reference laboratories...
October 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29029023/comprehensive-evaluation-of-the-effectiveness-and-safety-of-balloon-pulmonary-angioplasty-for-inoperable-chronic-thrombo-embolic-pulmonary-hypertension-long-term-effects-and-procedure-related-complications
#2
Tatsuo Aoki, Koichiro Sugimura, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Hideaki Suzuki, Haruka Sato, Katsuya Kozu, Ryo Konno, Satoshi Miyata, Kotaro Nochioka, Kimio Satoh, Hiroaki Shimokawa
Aims: Although balloon pulmonary angioplasty (BPA) improves haemodynamics and short-term prognosis in patients with inoperable chronic thrombo-embolic pulmonary hypertension (CTEPH), the long-term effects of BPA, and procedure-related complications remain to be fully elucidated. Methods and results: From July 2009 to October 2016, we performed a total of 424 BPA sessions in 84 consecutive patients with inoperable CTEPH. We used 3D reconstructed computed tomography to determine target lesions of pulmonary arteries and optical computed tomography to select balloon size, if needed...
September 23, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29028650/fast-digestive-proteins-and-sarcopenia-of-aging
#3
Yves Boirie, Christelle Guillet
PURPOSE OF REVIEW: The speed of dietary protein digestion influences postprandial amino acid availability which is crucial for improving altered anabolic response of skeletal muscle one feature of sarcopenia during aging. RECENT FINDINGS: By analogy with carbohydrate and in reference to their absorption rate, dietary proteins can be classified as 'fast' or 'slow' proteins depending on matrix food structure and technological processes, which can influence amino acids availability and their subsequent metabolic actions...
October 11, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29026725/effects-of-exercise-training-on-physical-fitness-and-biomarker-levels-in-breast-cancer-survivors
#4
REVIEW
Tae Ho Kim, Jae Seung Chang, In Deok Kong
BACKGROUND: Exercise has been identified as a beneficial intervention to enhance quality of life in breast cancer survivors. In addition, there has been a noteworthy increase in studies emphasizing the benefits of exercise in cancer. We sought to summarize the empirical literature concerning the effects of exercise on physical fitness and biomarker levels in breast cancer survivors according to the type of exercise. METHODS: We searched PubMed and PubMed Central for studies on the association of exercise with the levels of various biomarkers and physical fitness in breast cancer survivors...
July 2017: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/29025901/effects-of-age-and-exercise-training-on-coronary-microvascular-smooth-muscle-phenotype-and-function
#5
Judy M Muller-Delp, Kazuki Hotta, Bei Chen, Bradley Jon Behnke, Joshua J Maraj, Michael D Delp, Tiffani R Lucero, Jeremy A Bramy, David B Alarcon, Hannah E Morgan, Morgan R Cowan, Anthony D Haynes
Coronary microvascular function and blood flow responses during acute exercise are impaired in the aged heart, but can be restored by exercise training. Coronary microvascular resistance is directly dependent on vascular smooth muscle function in coronary resistance arterioles; therefore, we hypothesized that age impairs contractile function and alters the phenotype of vascular smooth muscle in coronary arterioles. We further hypothesized that exercise training restores contractile function and reverses age-induced phenotypic alterations of arteriolar smooth muscle...
October 12, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29025506/maintenance-of-lifestyle-changes-at-12-month-follow-up-in-a-nutrition-and-physical-activity-trial-for-cancer-survivors
#6
Fiona G Stacey, David R Lubans, Kathy Chapman, Alessandra Bisquera, Erica L James
OBJECTIVES: In this paper, we report maintenance of behavior change in a nutrition and physical activity intervention for cancer survivors at 12-months follow-up. METHODS: The ENRICH (Exercise and Nutrition Routine Improving Cancer Health) program was an 8-week face-to-face program for cancer survivors and caregivers, focused on healthy eating, healthy weight, resistance training, and a walking program. Randomized controlled trial participants completed a survey and 7-days of pedometry at baseline, 8-weeks, and 20-weeks...
November 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29023328/strength-and-conditioning-habits-of-competitive-distance-runners
#7
Richard C Blagrove, Nicola Brown, Glyn Howatson, Philip R Hayes
Blagrove, RC, Brown, N, Howatson, G, and Hayes, PR. Strength and conditioning habits of competitive distance runners. J Strength Cond Res XX(X): 000-000, 2017-Targeted strength and conditioning (S&C) programs can potentially improve performance and reduce injury risk factors in competitive runners. However, S&C practices of distance runners are unknown. This study aimed to explore S&C practices of competitive middle- and long-distance runners and examined whether reported frequency of injuries was influenced by training behaviors...
October 10, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29023317/effects-of-physical-exercise-in-older-adults-with-reduced-physical-capacity-meta-analysis-of-resistance-exercise-and-multimodal-exercise
#8
Chiung-Ju Liu, Wen-Pin Chang, Islene Araujo de Carvalho, Katie E L Savage, Lori W Radford, Jotheeswaran Amuthavalli Thiyagarajan
Older adults with reduced physical capacity are at greater risk of progression to care dependency. Progressive resistance strength exercise and multimodal exercise have been studied to restore reduced physical capacity. To summarize the best evidence of the two exercise regimes, this meta-analysis study appraised randomized-controlled trials from published systematic reviews. Medline, Embase, and the Cochrane Database of Systematic Review and Cochrane Central Register of Controlled Clinical Trials were searched for relevant systematic reviews...
October 11, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29023250/biomechanical-determinants-of-right-ventricular-failure-in-pulmonary-hypertension
#9
Francesco Scardulla, Diego Bellavia, Patrizio Vitulo, Giuseppe Romano, Chiara Mina, Giovanni Gentile, Francesco Clemenza, Salvatore Pasta
Pulmonary hypertension (PH) is a disease characterized by progressive adverse remodeling of the distal pulmonary arteries, resulting in elevated pulmonary vascular resistance and load pressure on the right ventricle (RV), ultimately leading to RV failure. Invasive hemodynamic testing is the gold standard for diagnosing PH, and guiding patient therapy. We hypothesized that lumped-parameter and biventricular finite-element (FE) modeling may lead to noninvasive predictions of both PH-related hemodynamic and biomechanical parameters that induce PH...
October 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29022275/volume-for-muscle-hypertrophy-and-health-outcomes-the-most-effective-variable-in-resistance-training
#10
Vandré Casagrande Figueiredo, Belmiro Freitas de Salles, Gabriel S Trajano
Resistance training is the most effective method to increase muscle mass. It has also been shown to promote many health benefits. Although it is deemed safe and of clinical relevance for treating and preventing a vast number of diseases, a time-efficient and minimal dose of exercise has been the focus of a great number of research studies. Similarly, an inverted U-shaped relationship between training dose/volume and physiological response has been hypothesized to exist. However, the majority of available evidence supports a clear dose-response relationship between resistance training volume and physiological responses, such as muscle hypertrophy and health outcomes...
October 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29021828/endurance-exercise-training-decreased-serum-levels-of-surfactant-protein-d-and-improved-aerobic-fitness-of-obese-women-with-type-2-diabetes
#11
Sajjad Rezaei, Mahdieh Molanouri Shamsi, Mehdi Mahdavi, Azadeh Jamali, Jonato Prestes, Ramires Alsamir Tibana, James Wilfred Navalta, Fabrício Azevedo Voltarelli
BACKGROUND: Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defense. To find the relationship between exercise training and SP-D in diabetes, we examined the possible effects of a 10-week endurance exercise-training program on serum levels of SP-D, leptin, lipid profile and insulin resistance in obese women with type-2 diabetes mellitus (T2DM). METHODS: Twenty-two obese women with T2DM were randomly assigned to either exercise training (ET) or control (C) group...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29020182/the-manufacturers-perspective-on-who-prequalification-of-in-vitro-diagnostics
#12
Sébastien Morin, Nelli Bazarova, Philippe Jacon, Stefano Vella
In vitro diagnostic devices (IVDs) help clinicians determine specific conditions, monitor therapeutic efficacy and prevent drug resistance development. While stringent regulatory authorities (SRAs) regulate IVDs in most high-income countries, regulatory authorities in many low- and middle-income countries (LMICs) are non-existent or do not enforce rigorous standards. In 2010, the World Health Organization (WHO) established its Prequalification of In Vitro Diagnostics (PQDx) Programme to ensure "access to safe, appropriate and affordable" IVDs, especially in LMICs with little or no domestic regulatory frameworks, thereby reaching underserved populations...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018628/combined-moderate-and-high-intensity-exercise-with-dietary-restriction-improves-cardiac-autonomic-function-associated-with-a-reduction-in-central-and-systemic-arterial-stiffness-in-obese-adults-a-clinical-trial
#13
Min Hu, Shen Wang, Dan Wang, Qinhao Lai, Xiaoying Chen, Shiwei Duan, Mengke Zhao, Junhao Huang
OBJECTIVE: The present study aimed to assess the effects of exercise with dietary restriction on cardiac autonomic activity, arterial stiffness, and cardiovascular biomarkers in obese individuals. METHODS: Seventeen obese adults completed an 8-week exercise and dietary program. Anthropometry, body composition, and multiple biochemical markers were measured. We used carotid-femoral pulse wave velocity (cfPWV), brachial-ankle pulse wave velocity (baPWV), central blood pressure, and augmentation index (AIx) to assess arterial stiffness...
2017: PeerJ
https://www.readbyqxmd.com/read/29018055/dose-response-effects-of-exercise-on-insulin-among-colon-cancer-survivors
#14
Justin Brown, Michael Rickels, Andrea Troxel, Babette Zemel, Nevena Damjanov, Bonnie Ky, Andrew Rhim, Anil Rustgi, Kerry S Courneya, Kathryn Schmitz
Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may include changes in metabolic growth factors, such as insulin. METHODS: Between January 2015 and August 2015, 39 stage I-III colon cancer survivors were randomized to one of three groups: usual-care control, 150 min∙wk-1 of aerobic exercise (low-dose), and 300 min∙wk-1 of aerobic exercise (high-dose) for six months...
October 10, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29018016/successful-treatment-of-community-acquired-methicillin-resistant-staphylococcus-aureus-purulent-myopericarditis
#15
Henry DeYoung, Adam Bloom, Sally Tamayo
A previously healthy 48-year-old active duty man, who had been treated for an elbow abscess 3 weeks earlier, presented to an emergency department in Bahrain with tachycardia, pericardial friction rub and jugular venous distention. Cardiac tamponade was confirmed on transthoracic echocardiogram and he was taken for emergent pericardiocentesis. Pericardial fluid cultures grew community-acquired methicillin-resistant Staphylococcus aureus Despite ongoing treatment with intravenous vancomycin, he developed a recurrent fibrinous pericardial effusion and constrictive pericarditis requiring pericardiectomy...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29016485/a-medically-supervised-pregnancy-exercise-intervention-in-obese-women-a-randomized-controlled-trial
#16
Niamh Daly, Maria Farren, Aoife McKeating, Ruth OʼKelly, Mary Stapleton, Michael J Turner
OBJECTIVE: To evaluate whether an intensive, medically supervised exercise intervention improved maternal glycemia and gestational weight gain in obese pregnant women when compared with routine prenatal care. METHODS: This randomized controlled trial compared a medically supervised exercise intervention with routine prenatal care. The primary outcome was a reduction in mean maternal fasting plasma glucose in the intervention group by 6.9 mg/dL at the time of a 75-g oral glucose tolerance test at 24-28 weeks of gestation...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28993264/sensory-mechanical-effects-of-a-dual-bronchodilator-and-its-anticholinergic-component-in-copd
#17
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, J Alberto Neder, Katherine A Webb
This randomized, double-blind, crossover study examined the physiological rationale for using a dual long-acting bronchodilator (umeclidinium/vilanterol (UME/VIL)) versus its muscarinic-antagonist component (UME) as treatment for dyspnea and exercise intolerance in moderate COPD. After each 4-week treatment period, subjects performed pulmonary function and symptom-limited constant-work rate cycling tests with diaphragm electromyogram (EMGdi), esophageal (Pes), gastric (Pga) and transdiaphragmatic (Pdi) pressure measurements...
October 6, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28993146/exercise-training-reverses-the-negative-effects-of-chronic-l-arginine-supplementation-on-insulin-sensitivity
#18
Rafael Barrera Salgueiro, Frederico Gerlinger-Romero, Lucas Guimarães-Ferreira, Thais de Castro Barbosa, Maria Tereza Nunes
L-Arginine has emerged as an important supplement for athletes and non-athletes in order to improve performance. Arginine has been extensively used as substrate for nitric oxide synthesis, leading to increased vasodilatation and hormonal secretion. However, the chronic consumption of arginine has been shown to impair insulin sensitivity. In the present study, we aimed to evaluate whether chronic arginine supplementation associated with exercise training would have a beneficial impact on insulin sensitivity...
October 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/28993117/getting-to-the-heart-of-the-matter-what-is-the-landscape-of-exercise-rehabilitation-for-people-with-heart-failure-in-australia
#19
Simon Miller, Allison Mandrusiak, Julie Adsett
BACKGROUND: The benefits of exercise rehabilitation for people with heart failure (HF) are well established. In Australia, little is known about how the guidelines around exercise rehabilitation for people with HF are being implemented in clinical practice. Furthermore, it is unknown what organisational barriers are faced in providing exercise rehabilitation programs for this population. The aim of this study is to provide an updated review of exercise rehabilitation services for people with HF in Australia and to identify perceived organisational barriers to providing these services...
September 25, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28991039/heavy-load-lifting-acute-response-in-breast-cancer-survivors-at-risk-for-lymphedema
#20
Kira Bloomquist, Peter Oturai, Megan L Steele, Lis Adamsen, Tom Møller, Karl Bang Christensen, Bent Ejlertsen, Sandra C Hayes
PURPOSE: Despite a paucity of evidence, prevention guidelines typically advise avoidance of heavy lifting in an effort to protect against breast cancer-related lymphedema. This study compared acute responses in arm swelling and related symptoms after low- and heavy-load resistance exercise among women at risk of lymphedema while receiving adjuvant taxane-based chemotherapy. METHODS: This is a randomized, cross-over equivalence trial. Women receiving adjuvant taxane-based chemotherapy for breast cancer who had undergone axillary lymph node dissection (n=21) participated in low- (60-65% 1 repetition maximum (RM), two sets of 15-20 repetitions) and heavy-load (85-90% 1RM, three sets of 5-8 repetition) upper-extremity resistance exercise separated by a one-week wash-out period...
October 4, 2017: Medicine and Science in Sports and Exercise
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