Nan Fang, Bing Liu, Qiuzhong Pan, Tingting Gong, Meixiao Zhan, Jingjing Zhao, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Fengze Sun, Ligong Lu, Jianchuan Xia
Hepatocellular carcinoma (HCC) has a pathogenesis that remains elusive with restricted therapeutic strategies and efficacy. This study aimed to investigate the role of SMG5, a crucial component in nonsense-mediated mRNA decay (NMD) that degrades mRNA containing a premature termination codon (PTC), in HCC pathogenesis and therapeutic resistance. We demonstrated an elevated expression of SMG5 in HCC and scrutinized its potential as a therapeutic target. Our findings revealed that SMG5 knockdown not only inhibited the migration, invasion, and proliferation of HCC cells but also influenced sorafenib resistance...
April 22, 2024: Molecular Cancer Therapeutics