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https://www.readbyqxmd.com/read/28635216/-ret-ptc-rearrangement-affects-multifocal-formation-of-papillary-thyroid-carcinoma
#1
X Zhang, X Su, W C Chen, Y Li, Z Y Yang, W Z Deng, T C Deng, A K Yang
Objective:RET/PTC gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of RET/PTC rearrangements with PTC clinical factors. Methods: From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Clinicopathological parameters, lifestyle, and thyroid hormone levels were collected. RET/PTC rearrangements were detected by TaqMan PCR and verified by Sanger sequencing...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28627279/maternal-autoimmune-disorders-and-fetal-defects
#2
Anca Maria Panaitescu, Kypros Nicolaides
Maternal autoantibodies can cross the placenta and cause fetal damage. This article summarizes the development and management of fetal thyroid goiter in response to maternal Graves' disease and/or its treatment with antithyroid medication, fetal heart block due to maternal anti-Ro and anti-La antibodies, fetal athrogryposis multiplex congenita in association with maternal myasthenia gravis and fetal brain hemorrhage due to maternal autoimmune thrombocytopenia.
June 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28626131/homozygous-duoxa2-mutation-p-tyr138-in-a-girl-with-congenital-hypothyroidism-and-her-apparently-unaffected-brother-case-report-and-review-of-the-literature
#3
Chiho Sugisawa, Shinji Higuchi, Masaki Takagi, Yukihiro Hasegawa, Matsuo Taniyama, Kiyomi Abe, Tomonobu Hasegawa, Satoshi Narumi
Mutations in DUOXA2, encoding dual oxidase maturation factor 2, is a rare genetic cause of congenital hypothyroidism. Only four biallelic DUOXA2 mutation carriers have been described to date. This study was conducted to report the clinical and genetic findings of a DUOXA2 mutation-carrying family, and to review the previously reported cases. The proband was a 4-year-old girl, who was diagnosed as having congenital hypothyroidism in the frame of newborn screening. She had a high serum TSH level (138 mU/L) and a low free T4 level (0...
June 16, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28620496/growth-hormone-and-insulin-like-growth-factor-1-affect-the-severity-of-graves-disease
#4
Alfredo Di Cerbo, Federica Pezzuto, Alessandro Di Cerbo
Graves' disease, the most common form of hyperthyroidism in iodine-replete countries, is associated with the presence of immunoglobulins G (IgGs) that are responsible for thyroid growth and hyperfunction. In this article, we report the unusual case of a patient with acromegaly and a severe form of Graves' disease. Here, we address the issue concerning the role of growth hormone (GH) and insulin-like growth factor 1 (IGF1) in influencing thyroid function. Severity of Graves' disease is exacerbated by coexistent acromegaly and both activity indexes and symptoms and signs of Graves' disease improve after the surgical remission of acromegaly...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28620008/pten-dicer1-fh-and-their-associated-tumor-susceptibility-syndromes-clinical-features-genetics-and-surveillance-recommendations-in-childhood
#5
REVIEW
Kris Ann P Schultz, Surya P Rednam, Junne Kamihara, Leslie Doros, Maria Isabel Achatz, Jonathan D Wasserman, Lisa R Diller, Laurence Brugières, Harriet Druker, Katherine A Schneider, Rose B McGee, William D Foulkes
PTEN hamartoma tumor syndrome (PHTS), DICER1 syndrome, and hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome are pleiotropic tumor predisposition syndromes that include benign and malignant neoplasms affecting adults and children. PHTS includes several disorders with shared and distinct clinical features. These are associated with elevated lifetime risk of breast, thyroid, endometrial, colorectal, and renal cancers as well as melanoma. Thyroid cancer represents the predominant cancer risk under age 20 years...
June 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28612896/total-thyroidectomy-the-first-the-best-the-recurrent-goiter-issue
#6
A Cappellani, A Zanghì, F Cardì, A Cavallaro, G Piccolo, S Palmucci, G Fuccio Sanzà, M Di Vita
BACKGROUND: Redo surgery for recurrent goiter is still now, even in experienced hands, followed by higher morbidity than primary total thyroidectomy. Suppressive Levothyroxine therapy failed to improve the recurrence rate, while inducing a subclinical hyperthyroidism. Aim of this study is to verify morbidity after total thyroidectomy for benign thyroid diseases, both primary and after recurrence. MATERIALS AND METHODS: A series of 20 cases of total thyroidectomy for recurrent benign diseases (RG), performed between January 2001 and December 2013 was compared with 225 cases of primary total thyroidectomy (PT) ...
May 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28604619/flavonoids-thyroid-iodide-uptake-and-thyroid-cancer-a-review
#7
REVIEW
Carlos F L Gonçalves, Mariana L de Freitas, Andrea C F Ferreira
Thyroid cancer is the most common malignant tumor of the endocrine system and the incidence has been increasing in recent years. In a great part of the differentiated carcinomas, thyrocytes are capable of uptaking iodide. In these cases, the main therapeutic approach includes thyroidectomy followed by ablative therapy with radioiodine. However, in part of the patients, the capacity to concentrate iodide is lost due to down-regulation of the sodium-iodide symporter (NIS), the protein responsible for transporting iodide into the thyrocytes...
June 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28602544/morbidity-of-total-thyroidectomy-for-substernal-goiter-a-series-of-70-patients
#8
N Tabchouri, Z Anil, F Marques, N Michot, P Dumont, V Arnault, L De Calan
Total thyroidectomy for substernal goiter occasionally requires a sternotomy associated with a cervical incision. We sought to analyze the postoperative complications of thyroidectomy for substernal goiters in our center and more precisely the complications related to the sternotomy. All patients who underwent total thyroidectomy for substernal goiter in our center between 2007 and 2016 were reviewed retrospectively. Patients with combined cervical incision and sternotomy (ST group, n=16) were compared to those with cervical incision alone (CT group, n=54), with regard to postoperative complications...
June 8, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28589091/when-is-thyroidectomy-the-right-choice-comparison-between-fine-needle-aspiration-and-final-histology-in-a-single-institution-experience
#9
Francesco Quaglino, Valentina Marchese, Enrico Mazza, Cristina Gottero, Riccardo Lemini, Stefano Taraglio
OBJECTIVES: The aim of this study was to compare SIAPEC-IAP-based cytological reports with their corresponding histological diagnoses to establish when thyroidectomy is the right choice in the management of thyroid diseases. STUDY DESIGN: This is a retrospective review of all the consecutive thyroidectomies/lobectomies performed at Maria Vittoria Hospital during the 10-year period between January 2005 and December 2015. Patients who underwent both fine-needle aspiration (FNA) and surgical procedures in our institution were included in the study...
April 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28588422/a-rare-case-of-poorly-differentiated-thyroid-carcinoma-probably-arising-from-a-nodular-goiter
#10
Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Ken-Ichi Yoshida, Kana Anno, Masayuki Tori, Masahiko Tsujimoto
BACKGROUND: Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare. CASE PRESENTATION: A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Carcinoma cells were arranged in trabecular, solid, and microfollicular histological patterns and displayed high mitotic activity...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28569050/serum-mir-146a-mir-155-and-mir-210-as-potential-markers-of-graves-disease
#11
Lei Zheng, Chunbo Zhuang, Xiaobei Wang, Liang Ming
BACKGROUND: Previous studies have demonstrated that dysfunctional regulatory T cells (Tregs) may be associated with Graves' disease (GD). In this study, we evaluated four serum Treg-associated miRNAs (miR-210, miR-182, miR-155, and miR-146a) expressions and assessed the potential of serum miRNAs as biomarkers of GD. METHODS: Foxp3 and serum miRNAs expressions both in GD patients and healthy controls were measured by RT-PCR. RESULTS: Serum miR-210 in GD patients was significantly higher than that of healthy controls (2...
May 31, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28562510/pancytopenia-and-hypothyroidism-in-a-patient-with-leukemic-infiltration-of-the-thyroid-as-the-first-presentation-of-acute-lymphoblastic-leukemia
#12
Christiaan F Mooij, Janiëlle A E M van Alfen-van der Velden, Romana T Netea-Maier, Roel Ten Broek, Martin Gotthardt, Melanie M Hagleitner
We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia...
May 29, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28552706/mother-young-recognition-in-goitered-gazelle-during-hiding-period
#13
D A Blank, W Yang
The mother-young recognition process is crucial for the growth and survival of progeny. In "follower" ungulate species, vocal and visual cues have been found to play a leading role in the mother-young identification process from the first days postpartum, with olfactory cues also important in establishing the initial selective mother-young bond immediately after birth. In "hider" species, however, much less has been documented of mother-young recognition behaviors, especially in their natural habitat. In this paper, we investigated this process in goitered gazelle (Gazella subgutturosa), a typical hider species, in its native environment in Kazakhstan...
May 24, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28551934/-parathyroid-autotransplantation-in-adults-and-children
#14
REVIEW
Michael M Krausz, Itamar Ashkenazi, Ricardo Alfici
The indications and methods of parathyroid autotransplantation in children and adults are reviewed, with special emphasis on the methods of immediate transplantation and delayed autotransplantation after cryopreservation. Parathyroid autotransplantation is performed during surgery when all four parathyroid glands have been intentionally resected in parathyroid hyperplasia, or when all four glands were inadvertently damaged during total thyroidectomy, or recurrent neck surgery. When parathyroid damage is suspected during thyroid or extensive neck surgery, cryopreservation of a parathyroid gland is performed...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551882/medical-geology-of-endemic-goiter-in-kalutara-sri-lanka-distribution-and-possible-causes
#15
G W A R Fernando, P L C L Liyanage, Anushka Upamali Rajapaksha, Meththika Vithanage
This study assesses the distribution of goiter in the Kalutara District, Sri Lanka in order to find causative factors for the occurrence of goiter even after the salt iodization. A questionnaire survey was conducted at the household level and at the same time iodine and selenium levels of the water sources were analyzed. Questionnaire survey results indicated the highest numbers of goiter patients in the northern part where the lowest were found in the southern sector which may be due to the presence of acid sulfate soils...
May 27, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28542048/case-report-of-a-massive-retropharyngeal-goiter-resulting-in-laryngeal-compression
#16
Carissa M Thomas, Jameson K Mattingly, Adrian Hendrickse, John I Song
This is a rare presentation of a morbidly obese male with a massive retropharyngeal goiter causing laryngeal compressive symptoms and unique airway management challenges. Flexible laryngoscopy revealed a retropharyngeal mass circumferentially compressing the oropharynx and supraglottis and preventing the visualization of the glottis. Awake tracheostomy was performed before total thyroidectomy. Airway compression from a goiter typically results from substernal extension, which usually does not cause difficulty with endotracheal intubation...
May 23, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28538410/extrapleural-solitary-fibrous-tumor-in-thymic-area-a-case-report
#17
Eun Kyung Jung, Young Yoon Kim, Dong Hoon Lee, Kyung Hwa Lee, Joon Kyoo Lee
RATIONALE: Solitary fibrous tumor (SFT) is a rare benign soft tissue mesenchymal neoplasm. There have been a few reports of extrapleural SFTs although it can occur anywhere in the body. PATIENT CONCERNS: A 30-year-old male presented with an anterior neck mass since one month. DIAGNOSES: Based on physical and radiologic examination, preliminary differential diagnosis was thymic neoplasm or intrathoracic goiter. INTERVENTIONS: We performed surgical excision of the neck mass...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535654/-expression-and-significance-of-nrf2-in-papillary-thyroid-carcinoma-and-thyroid-goiter
#18
W J Geng, L B Shan, J S Wang, N Li, Y M Wu
No abstract text is available yet for this article.
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28533836/primary-leiomyosarcoma-of-thyroid-gland-the-youngest-case
#19
Mouna Ayadi, Azza Gabsi, Khdija Meddeb, Amina Mokrani, Yosra Yahiaoui, Feryel Letaief, Nesrine Chraiet, Henda Rais, Amel Mezlini
Primary leiomyosarcomas of the thyroid gland are extremely rare. We report a case of a 32 year-old women with a multinodular goiter. She underwent total thyroidectomy. The tumor histology showed spindle-shaped cells that expressed desmine, caldesmone and smooth muscle actine but were negative cytokeratins.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28529587/expression-of-claudin-1-4-and-7-in-thyroid-neoplasms
#20
Dinç Süren, Mustafa Yildirim, Alper Sayiner, Arsenal Sezgin Alikanoğlu, Irem Atalay, Umut Riza Gündüz, Vildan Kaya, Şeyda Gündüz, Mehmet Tahir Oruç, Cem Sezer
The distinction of thyroid carcinoma from benign thyroid neoplasm, as well as the subtyping of papillary carcinoma (PC) and follicular carcinoma (FC), may be performed histopathologically in the majority of cases. However, in certain cases, it is difficult to histopathologically distinguish between PC and FC, as well as follicular adenoma (FA), FC and the dominant nodule of multinodular goiter (MNG-DN). The present study aimed to determine the roles of the expression levels of the tight junction proteins claudin 1, 4 and 7 in the differential diagnosis of PC, FC, FA, MNG-DN, medullary carcinoma (MC) and anaplastic carcinoma (AC)...
May 2017: Oncology Letters
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