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https://www.readbyqxmd.com/read/28439194/fetal-neonatal-hyperthyroidism-diagnostic-and-therapeutic-approachment
#1
REVIEW
Selim Kurtoğlu, Ahmet Özdemir
Fetal and neonatal hyperthyroidism may occur in mothers with Graves' disease. Fetal thyrotoxicosis manifestation is observed with the transition of TSH receptor stimulating antibodies to the fetus from the 17th-20th weeks of pregnancy and with the fetal TSH receptors becoming responsive after 20 weeks. The diagnosis is confirmed by fetal tachycardia, goiter and bone age advancement in pregnancy and maternal treatment is conducted in accordance. The probability of neonatal hyperthyroidism is high in the babies of mothers that have ongoing antithyroid requirement and higher antibody levels in the last months of pregnancy...
March 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28436636/-iodine-131-joint-radio-frequency-ablation-treatment-for-child-with-hyperthyroidism-goiter-one-case-report
#2
Yonghua Chen, Li Liang, Yanlan Fang, Chunlin Wang, Linfa Li, Tian'an Jiang
A 12-year-old girl presented with a history of cervical mass, and one week of throat discomfort and dyspnea. Five years ago, the patient was diagnosed as Hashimoto's thyroiditis and hyperthyroidism; she received antithyroid drug treatment, but the result was not satisfactory. B-ultrasonic showed that the size of thyroid gland was 8.1 cm×3.2 cm in the left and 8.2 cm×4.8 cm in the right. After iodine 131 combined with radiofrequency ablation (RFA) treatment, throat discomfort and recumbent breathing difficulties disappeared, and B-ultrasonic showed that the size of thyroid reduced to 2...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28432675/transoral-thyroidectomy-advantages-and-limitations
#3
G Dionigi, R P Tufano, J Russell, H Y Kim, E Piantanida, A Anuwong
In this opinion paper of the Journal of Endocrinological Investigation, leading experts in the field report on their current clinical experience with a novel approach for thyroid gland surgery, namely, "transoral thyroidectomy" (TOT). This feasible and novel surgical procedure does not require visible incisions and is, therefore, a truly scarless surgery. Patients meeting the following criteria can be considered as candidates for TOT: (a) an ultrasonographically (US) estimated thyroid diameter ≤10 cm; (b) US-estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) presence of a benign tumor such as a thyroid cyst or a single- or multi-nodular goiter; (e) Bethesda 3 and/or 4 category and (f) papillary microcarcinoma without the evidence of metastasis...
April 21, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28420409/assessing-the-status-of-iodine-deficiency-disorder-idd-and-associated-factors-in-wolaita-and-dawro-zones-school-adolescents-southern-ethiopia
#4
Shimelash Bitew Workie, Yemane Gebremariam Abebe, Amha Admasie Gelaye, Tefera Chane Mekonen
BACKGROUND: Iodine deficiency is the major preventable cause of irreversible mental retardation in the world. Ethiopia is a country with high prevalence of iodine deficiency disorders which continue to affect a large number of the country's population. The aim of the study was to assess the prevalence of iodine deficiency disorder in Wolaita and Dawuro zones. METHODS: A descriptive, cross-sectional study was conducted in high school and preparatory students in Wolaita and Dawuro zones between April and May 2012...
April 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28405949/transoral-endoscopic-thyroidectomy-preliminary-experience-in-italy
#5
Gianlorenzo Dionigi, Alessandro Bacuzzi, Matteo Lavazza, Davide Inversini, Luigi Boni, Stefano Rausei, Hoon Yub Kim, Angkoon Anuwong
Transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a feasible novel surgical procedure that does not need visible incisions. We describe our initial experience with TOETVA. We recruited 15 patients who were willing to undergo TOETVA. Inclusion criteria were (a) patients who had a neck ultrasound (US) with a estimated thyroid diameter not larger than 10 cm; (b) US estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (e) follicular neoplasm; (f) papillary microcarcinoma without evidence of metastasis...
April 12, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28400351/frequency-of-nodular-goiter-and-autoimmune-thyroid-disease-and-association-of-these-disorders-with-insulin-resistance-in-polycystic-ovary-syndrome
#6
Melia Karaköse, Sema Hepsen, Erman Çakal, Müyesser Saykı Arslan, Esra Tutal, Şafak Akın, İlknur Ünsal, Mustafa Özbek
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women. Nodular goiter and autoimmune thyroid disease (AITD) are the endocrinological abnormalities that have high prevalence. The purpose of our study was to detect the prevalence of AITD and nodular goiter in PCOS patients and investigate whether PCOS related hormones and metabolic factors affect these thyroid disorders. MATERIAL AND METHODS: Ninety-seven with PCOS and seventy-one healthy female volunteers were recruited in the study...
February 7, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28395497/-assessment-and-surgical-treatment-for-58-substernal-goiter
#7
X Zhu, Z C Huang, X Feng, F Tao
Objective: To investigate the diagnosis and treatment of substernal goiter. Methods: A total of 58 cases with substernal goiters undergoing surgery between January 2005 and December 2015 were analysed retrospectively. There were 10 males and 48 females and their age ranged from 38 to 82 years with a median age of 58 years. According to enhanced CT and clinical signs of substernal goiters, there were 40 cases for typeⅠ, 17 cases for type Ⅱ, and 1 case for type Ⅲ. Results: Patients with typeⅠand Ⅱ substernal goiters (8 cases of papillary carcinoma) underwent low neck and collar-type incision, and patients with type Ⅲ substernal goiters received carotid chest surgery...
March 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28389458/probable-interaction-between-levothyroxine-and-ritonavir-case-report-and-literature-review
#8
Rahul Sahajpal, Rabia A Ahmed, Christine A Hughes, Michelle M Foisy
PURPOSE: A case of probable interaction of levothyroxine and ritonavir is presented along with a review of the relevant literature and recommendations on clinical management. SUMMARY: A 37-year-old woman with human immunodeficiency virus infection who had recently undergone thyroidectomy for a benign multinodular goiter presented to a clinic with hypothyroidism (she was also found to be pregnant), and treatment with levothyroxine 75 μg daily was initiated. While receiving antiretroviral therapy (abacavir-lamivudine and lopinavir-ritonavir) during pregnancy, the patient had persistently elevated serum thyroid-stimulating hormone (TSH) concentrations (up to 125...
April 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28388869/annals-express-stimulating-tsh-receptor-autoantibodies-immunoassay-analytical-evaluation-and-clinical-performance-in-graves-disease
#9
Chiara Autilio, Renato Morelli, Pietro Locantore, Alfredo Pontecorvi, Cecilia Zuppi, Cinzia Carrozza
BACKGROUND: Thyroid stimulating hormone (TSH) receptor (TSHR) autoantibodies (TRAbs) are a heterogeneous group of antibodies (Abs) with different functionality. Among all TRAbs only the stimulating one (S-TRAbs) are considered the pathogenetic marker of Graves' Disease (GD). To date, the methods available for TRAbs testing are based on immunoassays (IMAs) which detect total serum TRAbs or bioassays which are not suitable in clinical practice, even though they discern Abs functionality...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28387647/management-of-childhood-thyroid-nodules-surgical-and-endocrinological-experience-in-more-than-one-hundred-cases
#10
Emre Divarcı, Ülgen Celtik, Zafer Dökümcü, Orkan Ergün, Geylani Özok, Samim Özen, Damla Gökşen Şimşek, Şükran Darcan, Nazan Çetingül, Aylin Oral, Yeşim Ertan, Bengü Demirağ, Ahmet Çelik
OBJECTIVE: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children. METHODS: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Detailed ultrasonography and fine needle aspiration biopsy(FNAB) were the corner stones of the diagnostic approach. RESULTS: One hundred-three children(72F,31M) with a mean age of 13...
April 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28387096/-a-familial-non-medullary-thyroid-carcinoma-fnmtc-a-clinical-and-genetic-update
#11
REVIEW
H Valdes-Socin, L Palmeira, M-C Burlacu, A-F Daly, V Bours, A Beckers
The syndrome of Familial Non Medullary Thyroid Carcinoma (FNMTC) includes two or more patients with an isolated non-medullary thyroid cancer (papillary, follicular, anaplastic) within the same family. To diagnose FNMTC, the clinician must exclude a syndromic presentation such as the syndromes of Cowden, Gardner or Werner, and the Carney Complex. Up to now, a hundred families with FNMTC have been genetically studied, including forms with (Ch19p13.2) or without oxyphilia (Ch2q21), in association with a multinodular goiter (Ch14q32), or with a renal cancer (Ch1q21)...
December 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28384929/a-case-report-on-multiple-stones-in-the-thyroid-gland-in-association-with-sclerosing-thyroiditis-an-unusual-encounter
#12
Gaurav Shandilya, Ravish Kumar Sinha, Nishith Ekka, Vinod Kumar
Stones are very frequently found in the gallbladder and urinary tract. Rarely the thyroid gland can be a site for stone formation. Few cases of calcification in thyroid gland have been described in the medical literature in association with papillary carcinoma and multinodular goiter. A unique case of a thyroid swelling studded with multiple stones in its parenchyma, in the histopathological background of sclerosing thyroiditis in an 80-year-old male is documented here. Surgical excision was undertaken with an uneventful postoperative period...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28383300/nevi-ambient-ultraviolet-radiation-and-thyroid-cancer-risk-a-french-prospective-study
#13
Sylvie Mesrine, Marina Kvaskoff, Thierno Bah, Lucien Wald, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault
BACKGROUND: Incidence rates have increased considerably worldwide for both differentiated thyroid cancer and cutaneous melanoma, and two-way associations between these neoplasms have been described. Whether melanoma risk factors are associated with thyroid cancer risk remains unknown. METHODS: Using Cox regression modeling, we prospectively analyzed the relationship between self-reported pigmentary traits, baseline residential ultraviolet (UV) exposure, and thyroid cancer risk in 86,960 women from the E3N cohort, followed-up over 1990-2008 through biennial questionnaires...
April 5, 2017: Epidemiology
https://www.readbyqxmd.com/read/28381452/management-of-endocrine-disease-arguments-for-the-prolonged-use-of-antithyroid-drugs-in-children-with-graves-disease
#14
Juliane Leger, Jean-Claude Carel
Graves' disease is an autoimmune disorder. It is the major cause of hyperthyroidism but is rare in children. Patients are initially managed with antithyroid drugs (ATD), in the form of methimazole/carbimazole. A major disadvantage of ATD treatment is the high risk of relapse, exceeding 70% of children treated for a duration of two years, and the potential major side effects of the drug reported in exceptional cases. The major advantage of ATD treatment is that normal homeostasis of the hypothalamus-pituitary thyroid axis may be restored, with periods of drug treatment followed by freedom from medical intervention achieved in about 40 to 50% of cases after prolonged ATD treatment for several years in recent studies...
April 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28373882/increased-chromosomal-and-oxidative-dna-damage-in-patients-with-multinodular-goiter-and-their-association-with-cancer
#15
Hamiyet Donmez-Altuntas, Fahri Bayram, Nazmiye Bitgen, Sibel Ata, Zuhal Hamurcu, Gulden Baskol
Thyroid nodules are a common clinical problem worldwide. Although thyroid cancer accounts for a small percentage of thyroid nodules, the majority are benign. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) levels are a marker of oxidative stress and play a key role in the initiation and development of a range of diseases and cancer types. This study evaluates cytokinesis-block micronucleus cytome (CBMN-cyt) assay parameters and plasma 8-OHdG levels and their association with thyroid nodule size and thyroid hormones in patients with multinodular goiter...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28368444/cyclic-peptides-for-effective-treatment-in-a-long-term-model-of-graves%C3%A2-disease-and-orbitopathy-in-female-mice
#16
Hans-Peter Holthoff, Zhongmin Li, Julia Faßbender, Andreas Reimann, Kristin Adler, Götz Münch, Martin Ungerer
A model for human Graves´ disease in mice was used to compare several novel treatment approaches. The mice received regular adenoviral (Ad) thyroid-stimulating receptor (TSHR) A subunit immunisations (4-weekly injections). Generation of anti-TSHR antibodies, enlarged thyroid sizes (goiter), elevated serum thyroxin levels, retro-orbital fibrosis and cardiac involvement (tachycardia and hypertrophy) were consistently observed during 9 months.Treatment of established disease in these mice with novel cyclic peptides which mimic one of the cylindrical loops of the TSHR leucin-rich repeat domain improved or even cured all investigated parameters after 6 consecutive monthly injections...
March 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/28368069/-congenital-goiter-in-the-neonatal-foal-two-case-reports
#17
Jennifer Nieth, Kernt Köhler, Axel Wehrend
Two cases of an innate hyperplastic goiter in foals as well as the sonographic evaluation of the hyperplastic gland are presented. One foal displayed skeletal deformities in the form of a mandibular prognathism and forelimb contractures in addition to the swollen thyroid gland. Because of a poor prognosis, the animal was euthanized. The second foal was premature and displayed respiratory signs. Under symptomatic therapy, the goiter regressed within a few weeks.
April 3, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28356911/factors-associated-with-the-prevalence-of-thyroid-nodules-and-goiter-in-middle-aged-euthyroid-subjects
#18
Dalia Dauksiene, Janina Petkeviciene, Jurate Klumbiene, Rasa Verkauskiene, Jelena Vainikonyte-Kristapone, Audrone Seibokaite, Jonas Ceponis, Vygantas Sidlauskas, Laura Daugintyte-Petrusiene, Antanas Norkus, Birute Zilaitiene
The aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and thyroid nodules in middle-aged euthyroid subjects. Methods. The study consisted of 317 euthyroid subjects aged 48-49 from the Kaunas Cardiovascular Risk Cohort study. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and antithyroid peroxidase antibody (ATPO) levels, as well as anthropometric and metabolic parameters and smoking information, were evaluated...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28348999/goiter-prevalence-in-school-going-children-a-cross-sectional-study-in-two-border-districts-of-sub-himalayan-jammu-and-kashmir
#19
Rajiv Kumar Gupta, Bhavna Langer, Sunil Kumar Raina, Rashmi Kumari, Reyaz Jan, Renu Rani
INTRODUCTION: Iodine deficiency disorder remains one of the major public health problems, despite it being easily preventable. Initially thought as the disorder of Himalayan goiter belt, the disorder has been found to have a pan-India presence. The study was planned with the aim to assess the prevalence of goiter among 6-12 years school-going children and to identify levels of iodine in salt consumed at the household level in the study area. MATERIALS AND METHODS: The study was conducted among 3955 school-going (2162 children from Rajouri and 1793 children from Poonch) children age 6-12 years in Rajouri and Poonch districts of Jammu Province...
October 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28348902/atypical-complications-of-graves-disease-a-case-report-and-literature-review
#20
Khaled Ahmed Baagar, Mashhood Ahmed Siddique, Shaimaa Ahmed Arroub, Ahmed Hamdi Ebrahim, Amin Ahmed Jayyousi
Graves' disease (GD) may display uncommon manifestations. We report a patient with rare complications of GD and present a comprehensive literature review. A 35-year-old woman presented with a two-week history of dyspnea, palpitations, and edema. She had a raised jugular venous pressure, goiter, and exophthalmos. Laboratory tests showed pancytopenia, a raised alkaline phosphatase level, hyperbilirubinemia (mainly direct bilirubin), and hyperthyroidism [TSH: <0.01 mIU/L (reference values: 0.45-4.5), fT4: 54...
2017: Case Reports in Endocrinology
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