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https://www.readbyqxmd.com/read/29452573/the-effect-of-metformin-treatment-in-obese-insulin-resistant-patients-with-euthyroid-goiter
#1
Nicoleta Răcătăianu, Sorana Daniela Bolboacă, Adela-Viviana Sitar-Tăut, Smaranda Mârza, Daniela Moga, Ana Valea, Cristina Ghervan
Objective The study's objective was to evaluate the thyroid parameters in obese insulin-resistant patients with euthyroid diffuse or nodular goiter, following Metformin treatment. Patients and methods The study was experimental, open, and prospective. Fifty-three patients aged 18-68 were enrolled for two years. Obese insulin-resistant patients (cut-off Homeostasis-Model-Assessment of Insulin Resistance-HOMA-IR ≥ 2.5) with euthyroid nodular/diffuse goiter were included. Subjects with diabetes, hypo-/hyper-thyroidism, autoimmune thyroiditis, psychiatric disorders, liver or heart failure were excluded...
February 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29442060/thyroid-hemiagenesis-associated-with-multinodular-goiter-and-hashimoto-s-thyroiditis
#2
Daniela Bosco, A Cammarata, R Cannarella, R Latino, R Lanteri, A Di Cataldo, A Calogero
Thyroid hemiagenesis is a rare congenital abnormality in which one of the thyroid lobes is not developed. It can be associated with various thyroid diseases, such as Grave's disease, nodular goiter and thyroid neoplasm, rarely with hyperparathyroidism. We report a case of a 50-year old woman with left thyroid lobe agenesis diagnosed by ultrasonography and scintigraphy. Right thyroidectomy was performed and the histopathological examination showed diffuse hyperplasia, multinodular goiter and Hashimoto's thyroiditis...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29438906/alteration-in-the-serum-concentrations-of-fgf19-fgfr4-and-%C3%AE-klotho-in-patients-with-thyroid-cancer
#3
Ewelina Motylewska, Tomasz Stępień, Magdalena Borkowska, Krzysztof Kuzdak, Agnieszka Siejka, Jan Komorowski, Henryk Stępień, Hanna Ławnicka
INTRODUCTION: βKlotho (βKL) is known to act as co-receptor for fibroblast growth factor receptor 4 (FGFR4) which is the main cognate receptor for fibroblast growth factor 19 (FGF19). Dysregulation of this FGF19/FGFR4/βKL signaling axis has been implicated in the pathogenesis of several cancers. However, its role in the pathogenesis of thyroid cancer has not been determined. MATERIALS AND METHODS: The aim of this study was to assess FGF19, FGFR4 and βKL concentrations in a group of 36 patients with papillary thyroid cancer (PTC), 11 patients with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and a group of 19 subjects with multinodular nontoxic goiter (MNG)...
February 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29435670/diagnostic-accuracy-of-a-new-fluoroenzyme-immunoassay-for-the-detection-of-tsh-receptor-autoantibodies-in-graves-disease
#4
Danilo Villalta, Federica D'Aurizio, Mirella Da Re, Debora Ricci, Francesco Latrofa, Renato Tozzoli
PURPOSE: Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves' disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme immunoassay for TRAb measurement in GD, in comparison with two current IMAs. METHODS: Sera of 439 subjects (57 patients with untreated GD, 34 with treated GD, 15 with GD and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiA ™ anti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAK ™ RIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the Immulite ™ TSI assay (Siemens Healthcare, Llanberis, UK)...
February 12, 2018: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/29435108/genetic-and-functional-analysis-of-two-missense-duox2-mutations-in-congenital-hypothyroidism-and-goiter
#5
Shiguo Liu, Wenhui Zhang, Liqin Zhang, Hui Zou, Kunna Lu, Qiang Li, Hongfei Xia, Shengli Yan, Xu Ma
Mutations in the dual oxidase 2 gene ( DUOX2 ) impair hydrogen peroxide (H 2 O 2 ) production and cause dyshormonogenesis. In addition, these mutations have been implicated in autosomal recessive congenital hypothyroidism (CH) with goiter. In this study, we identified DUOX2 mutations that were causative for CH and explored the effects of these mutations on DUOX2 function. Blood samples were collected from 10 infants born with CH and goiter to unrelated parents. We extracted genomic DNA and sequenced all exons by polymerase chain reaction direct sequencing...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29412382/thyroid-disorders-in-obese-patients-does-insulin-resistance-make-a-difference
#6
Nicoleta Răcătăianu, Nicoleta Leach, Cosmina Ioana Bondor, Smaranda Mârza, Daniela Moga, Ana Valea, Cristina Ghervan
OBJECTIVE: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the results between insulin-resistant and noninsulin-resistant patients. SUBJECTS AND METHODS: Obese/nondiabetic patients, aged 18-70 years, attending the outpatient endocrinology service for 2 years were consecutively included. We evaluated the patients' fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), thyroid-stimulating hormone (TSH), free thyroxine (FT4), antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (Tg-Ab), and thyroid ultrasound...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29409365/a-single-session-of-laser-ablation-for-toxic-thyroid-nodules-three-year-follow-up-results
#7
Giovanni Gambelunghe, Elisa Stefanetti, Renato Colella, Massimo Monacelli, Nicola Avenia, Pierpaolo De Feo
PURPOSE: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up. MATERIAL AND METHODS: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goiter. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated...
February 6, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29406821/effect-of-goiter-dispersion-formula-on-serum-cytokines-in-hyperthyroidism-patients-with-neurologic-manifestations-of-graves-disease-a-randomized-trial-on-80-cases
#8
Wen-Hong Tian, Ying Wang, Rui Yang, Hai-Bing Hu
PURPOSE: This study is aimed to explore the combined use of goiter dispersion formula and antithyroid drugs in the treatment of patients with neurologic manifestations of Graves' disease by examining its modulating effects on patients' cytokines. METHODS: A total of 80 patients with Graves' disease were randomly divided into treatment and control groups. Patients of the treatment group received goiter dispersion formula and antithyroid drugs (methimazole or propylthiouracil), whereas those of the control group received antithyroid drug alone...
February 6, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29406334/hmga2-gene-expression-in-fine-needle-aspiration-samples-of-thyroid-nodules-as-a-marker-for-preoperative-diagnosis-of-thyroid-cancer
#9
Ivan Šamija, Neven Mateša, Sanja Kožaj, Ivana Majstorović, Ante Bolanča, Zvonko Kusić
There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction...
February 5, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29396967/frequency-of-thyroid-stimulating-hormone-monitoring-in-patients-after-thyroidectomy-a-retrospective-study-in-primary-care-practices-in-germany
#10
Karel Kostev, Margarethe Winiarski, Lisa Schüller, Andreas M Sesterhenn, Louis Jacob
AIM: The goal of this study was to analyze the frequency of thyroid-stimulating hormone (TSH) monitoring in thyroidectomy patients followed by general practitioners in Germany. METHODS: This study included all individuals ≥18 years who had undergone a thyroidectomy between 2000 and 2015 in 258 general practices in Germany. Another inclusion criterion was a minimum of three medical visits between 2015 and 2016, following thyroidectomy. The primary outcome was the annual frequency of TSH monitoring in thyroidectomy patients in 2015...
February 2, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29395824/when-cardiopulmonary-bypass-is-not-an-option-a-case-of-massive-retrosternal-goiter-with-severe-tracheal-compression-in-an-extremely-obese-patient
#11
Phillip Kwan-Giet Lee, Anton Willis Gerard Booth, Benjamin Simon Lloyd
No abstract text is available yet for this article.
June 17, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29390279/ectopic-thyrotropin-secreting-pituitary-adenoma-concomitant-with-papillary-thyroid-carcinoma-case-report
#12
Jing Yang, Shu Liu, Zhe Yang, Yin Bing Shi
RATIONALE: Ectopic thyrotropin (TSH)-secreting pituitary adenomas are exceedingly rare. To date, there are only 6 cases reported. Here, we describe an even rarer ectopic TSH-secreting pituitary adenoma (TSH-oma) concomitant with papillary thyroid carcinoma. PATIENT CONCERNS: A 27-year-old female was admitted to the hospital in 2002 for neck enlargement and palpitation. Thyroid function test showed increased thyroid hormones and unrepressed TSH. Thyroid ultrasound examination displayed diffuse goiter...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383239/abnormal-distance-of-the-extralaryngeal-bifurcation-point-of-the-recurrent-laryngeal-nerve-from-the-cricothyroid-joint
#13
Theodoros Piperos, Ioannis Kaklamanos, Dimosthenis Chrysikos, Maria Zarokosta, Eleni Boumpa, Menelaos Zoulamoglou, Vasileios Kalles, Georgia-Ioanna Gkogka, Theodoros Mariolis-Sapsakos
The extralaryngeal bifurcation point of the recurrent laryngeal nerve (RLN) is typically located in a mean distance of 0-2 cm from the cricothyroid joint (CTJ). In the presented case though, the left RLN was unexpectedly identified bifurcating in a mean distance of 7 cm from the left CTJ in a young woman with multinodular goiter during total thyroidectomy. The RLN was carefully exposed throughout its course for the avoidance of iatrogenic injury of the nerval structure. The operation was uneventful. The present manuscript aims to highlight a scarce anatomic variation and its implications for thyroidectomy...
January 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29380231/riedel-s-thyroiditis-clinical-presentation-treatment-and-outcomes
#14
Henrik Falhammar, Carl Christofer Juhlin, Caroline Barner, Sergiu-Bogdan Catrina, Christos Karefylakis, Jan Calissendorff
BACKGROUND: Riedel´s thyroiditis (RT) is a rare inflammatory disease of the thyroid gland, causing compression and fibrosis of adjacent tissues. Typically the goiter is hard and firm. Hoarseness, dyspnea, and dysphagia may be present. METHODS: We retrospectively reviewed all patients known by us with RT in addition to all patients with appropriate ICD-10 codes evaluated at the Karolinska University Hospital 2003-2015. Clinical, biochemical, and histological data of patients with RT were recorded in detail...
January 29, 2018: Endocrine
https://www.readbyqxmd.com/read/29379895/aberrant-iodine-autoregulation-induces-hypothyroidism-in-a-mouse-strain-in-the-absence-of-thyroid-autoimmunity
#15
Sandra M McLachlan, Holly A Aliesky, Basil Rapoport
We investigated factors underlying the varying effects of a high dietary iodide intake on serum T4 levels in a wide spectrum of mouse strains, including thyroiditis-susceptible NOD.H2h4, NOD.H2k, and NOD mice, as well as other strains (BALB/c, C57BL/6, NOD.Lc7, and B10.A4R) not previously investigated. Mice were maintained for up to 8 months on control or iodide-supplemented water (NaI 0.05%). On iodized water, serum T4 was reduced in BALB/c (males and females) in association with colloid goiters but was not significantly changed in mice that developed thyroiditis, namely NOD...
January 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29374396/thyroid-adenolipoma-a-case-report
#16
Monica Pennisi, Alessandro Conti, Renato Farina, Pietro Valerio Foti, Giuseppe Cocuzza, Andrea Boncoraglio, Valeria Costanzo, Giuliana Costanzo
Generally, small quantities of adipose tissue is present in the thyroid gland. The adenolipoma of the thyroid gland is considered a rare finding. It consists in a benign, encapsulated neoplasm composed of mature adipose tissue and glandular elements. We report a case of a 71 year-old female patient presenting with swelling of the anterior neck and history of airway obstruction. Ultrasound (US) examination showed a bulky multinodular goiter which caused dislocation and compression of the trachea. The scans performed at the level of the isthmic region showed the presence of a hyperechoic oval formation with a homogeneous echostructure and regular contours; these characteristics suggested the lipomatous nature of the nodule...
November 30, 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29360235/obviating-the-need-for-sternotomy-safety-and-effectiveness-of-microdebrider-use-for-retrosternal-goiter
#17
Elad Dagan, Stephen Kleid
BACKGROUND: Most retrosternal goiter surgical removal can be performed via a transcervical approach. However, it is often a challenging procedure, which might include sternotomy. METHODS: We describe a surgical technique using a microdebrider for intracapsular volume reduction that precedes an extracapsular thyroidectomy, thereby avoiding the need for sternotomy, with decreased morbidity and risk. The procedure is described in detail with 2 representative cases and a summary of our experience in 26 cases...
January 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29359203/rare-undiagnosed-primary-amyloidosis-unmasked-during-surgical-treatment-of-primary-hyperparathyroidism-a-case-report
#18
Kathleen C Gallagher, Ariana B Geromes, John Stokes, India A Reddy, James S Lewis, Naira Baregamian
Primary amyloidosis (PA) is a protein deposition disorder that presents with localized or multisystemic disease. The incidence is low in the general public, ranging from three to eight cases per million, and with nonspecific presenting symptoms typically occurring later in life. Due to late presentation, substantial and irreversible damage has usually already occurred by the time of the diagnosis. However, if inadvertent diagnosis occurs before irreversible damage has taken place, as it did in the following case, some patients may benefit from the disease-arresting treatment...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29356740/incidental-detection-of-a-melanoma-by-18f-fluorocholine-pet-ct-performed-for-evaluation-of-primary-hyperparathyroidism
#19
Anne Marij Geertruida Burgers, Maurits Wondergem, Friso Martijn van der Zant, Remco Johannes Jacob Knol
An 80-year-old woman was evaluated with F-fluorocholine PET/CT in suspicion of a parathyroid adenoma. No focal parathyroid tracer uptake suggestive of adenoma was found, and instead a unilateral multinodular goiter without elevated F-fluorocholine uptake was diagnosed. In addition, focal uptake was found in a cutaneous nodule dorsally on the right shoulder. Upon pathological evaluation, this proved to be a malignant melanoma.
January 19, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29355489/itraq-analysis-of-urinary-proteins-potential-use-of-gelsolin-and-osteopontin-to-distinguish-benign-thyroid-goiter-from-papillary-thyroid-carcinoma
#20
Jaime Jacqueline Jayapalan, Cheng-Siang Lee, Ching Chin Lee, Khoon Leong Ng, Sarni Mat Junit, Onn Haji Hashim
No abstract text is available yet for this article.
January 17, 2018: Clinical Biochemistry
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