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Zahra Eslami, Mahsa Torabizadeh, Zahra Talebpour, Mohammad Talebpour, Alireza Ghassempour, Hassan Y Aboul-Enein
During a decade and more since its discovery, the emerging physiological roles of ghrelin in mammalian are increasingly being introduced, proposing a critical need for its quantification in biological milieu. Here in, a simple and sensitive single-step method for extraction and quantification of ghrelin in human plasma was developed and validated using stir bar sorptive extraction (SBSE) followed by high-performance liquid chromatography (HPLC) with diode array detection (DAD) coupled to mass spectrometry (MS)...
August 9, 2016: Journal of Chromatographic Science
Renata Stawerska, Małgorzata Szałapska, Maciej Hilczer, Andrzej Lewiński
BACKGROUND: In children born small for gestational age (SGA) with catch-up growth, a higher risk of insulin resistance (IR) and cardiovascular diseases is noted. Ghrelin stimulates a growth hormone (GH) secretion and regulates lipid and carbohydrate metabolism. We assessed gherlin's influence on achieving normal height and the occurrence of metabolic complications in SGA children. METHODS: Ghrelin, insulin-like growth factor type I (IGF-I), leptin, adiponectin, resistin, glucose, insulin and lipid concentrations were analysed in 134 prepubertal children in four groups: normal-height SGA, short SGA, normal-height born appropriate for gestational age (AGA) and short AGA...
August 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Wenlong Zhang, Gaoshui Yu, Yong Huang, Dan Xu, Jingjing Ren, Liang Jiang, Changlong Wu, Dewen Tong
Recent studies have implicated the peripheral actions of ghrelin in reproductive tissues. The present study provides novel evidence for the expression of ghrelin and its functional receptor (GHSR-1a) in the mammary glands of dairy goat during lactation and the effects of ghrelin on regulation of mammary function in vitro. Ghrelin and GHSR-1a mRNA and protein were persistently detected in goat mammary glands throughout the lactation, and patterns of expression of ghrelin, GHSR-1a and β-casein were generally similar, with highest levels during peak milk yield (day 60-120 of lactation) and lower levels during late (day 180) of lactation...
May 6, 2013: Molecular and Cellular Endocrinology
H R Hady, J Dadan, P Gołaszewski
PURPOSE: Obesity is a widespread health issue caused by chronic impaired balance between energy supply and its expenditure. It leads to gathering of excessive fat tissue and numerous co-morbidities.The aim of this study is to present the influence of laparoscopic adjustable gastric banding (LAGB) on plasma ghrelin, insulin, glucose, triglycerides, total, HDL- and LDL-cholesterol concentration as well as on alanine and aspartate aminotransferase in obese patients and influence on co-morbidities such as type 2 diabetes mellitus, dislipidemy, hypertension and sleep apnea...
June 1, 2012: Advances in Medical Sciences
Hui-Ming Yang, Meng Mao, Fan Yang, Su-Fei Yang, Fei Xiong
OBJECTIVE: To study the relationship between Ghrelin and growth hormone secretagogue receptor (GHSR) expression and the catch-up growth in rats with intrauterine growth restriction (IUGR). METHODS: The rat model of IUGR was established by food restriction during pregnancy. The small for gestational age (SGA) and appropriate for gestational age (AGA) rat pups from the pregnant rats were used as the experimental group. The AGA rat pups from the pregnant rats without food restriction served as the control group...
July 2010: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
A Dei Cas, A Muoio, I Zavaroni
Chronic heart failure (CHF) is a major health problem that carries a devastating prognosis. The prognosis worsens considerably once cardiac cachexia has been diagnosed. Neurohormonal, metabolic, hemodynamic and immunological alterations are involved in the initiation and progression of cardiac cachexia. Cachexia is characterized by a hypothalamic inappropriate response to the mechanisms controlling energy homeostasis. Levels of the anorexigenic hormone leptin are decreased whereas the orexigenic gherlin hormone levels are normal or elevated...
December 2011: Minerva Cardioangiologica
Christina I Messini, Konstantinos Dafopoulos, Nektarios Chalvatzas, Panagiotis Georgoulias, George Anifandis, Ioannis E Messinis
OBJECTIVE: To investigate the effect of bromocriptine on ghrelin-induced PRL secretion in women. DESIGN: Longitudinal study. SETTING: University hospital. PATIENT(S): Ten healthy, normally cycling women. INTERVENTION(S): The women were injected IV on day 3 of three cycles with a single dose of normal saline (cycle 1) or ghrelin (1 microg/kg) after pretreatment for 2 days either with placebo (cycle 2) or with bromocriptine (cycle 3) per os...
September 2010: Fertility and Sterility
E A Shuster
The function of hormones has expanded to include immunomodulation and neuroprotection in addition to their classic roles. The story of how hormones influence inflammation and neuron and glial function is being slowly unraveled. There is increasing evidence that estrogen, progesterone, and testosterone contain immune responses and influence damage repair in the nervous system. Hormones such as prolactin and vitamin D are being explored as immunomodulators and may influence diseases such as multiple sclerosis (MS) or may be used therapeutically to modulate the immune response...
2008: Current Topics in Microbiology and Immunology
Qian Wang, Lynda Elghazi, Sophie Martin, Isabelle Martins, R Satish Srinivasan, Xin Geng, Mark Sleeman, Patrick Collombat, Janet Houghton, Beatriz Sosa-Pineda
Pax4-deficient mice have a severe gastrointestinal endocrine deficiency: they lack most pancreatic cells that produce insulin or somatostatin and various duodenal endocrine cell types. Remarkably, Pax4-deficient mice also have an overabundance of ghrelin-expressing cells in the pancreas and duodenum. Detailed analysis of the Pax4 nullizygous pancreas determined that the mutant islets are largely composed of a distinctive endocrine cell type that expresses ghrelin, glucagon, islet amyloid polypeptide (IAPP), and low levels of Pdx1...
January 2008: Developmental Dynamics: An Official Publication of the American Association of Anatomists
Eman El Eter, Ali Al Tuwaijiri, Hanan Hagar, Maha Arafa
BACKGROUND AND AIM: Gherlin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R), is produced by stomach cells. It regulates food intake, gastric secretion and motility. However, its role as a protective agent in gastric ischemia/reperfusion (I/R) injury has not yet been investigated. Therefore, the objectives of the present study were to: (i) test the in vivo effect of peripherally administered ghrelin on gastric I/R-induced lesions in rats; and (ii) investigate in vitro the effect of ghrelin on reactive oxygen species (ROS) production by human polymorphoneuclear (PMN) cells...
November 2007: Journal of Gastroenterology and Hepatology
J Skommer, K Katulski, E Poreba, B Meczekalski, R Slopień, R Plewa, A Gozdzicka-Józefiak, A Warenik-Szymankiewicz
The etiology and pathogenesis of polycystic ovary syndrome (PCOS) is still unknown. Using real-time PCR, we detected that polycystic ovaries showed almost ten times lower expression of ghrelin mRNA than normal ovaries, whereas the mRNA levels in blood cells were similar in both study groups. This suggests that the presence of ghrelin in PCOS and normal ovaries may have an autocrine/paracrine modulatory effect on ovary functions and local significance in the etiology of PCOS.
2005: European Journal of Gynaecological Oncology
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