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Dog renal failure

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https://www.readbyqxmd.com/read/27892876/low-expression-of-cyclooxygenase-2-in-chronic-kidney-disease-in-young-dogs
#1
Akira Yabuki, Akiko Miyazaki, Osamu Ichii, Moeko Kohyama, Mariko Sawa, Osamu Yamato
Chronic kidney disease (CKD) often results in end-stage renal failure in young dogs; however, the pathogenesis of this disease is not established. This study investigated renal expression of cyclooxygenase (COX)-1 and COX-2 proteins in three dogs with chronic kidney disease by immunohistochemistry. Histopathology showed asynchronous differentiation of renal tissues, including immature glomeruli. COX-1 signals were not detected in diseased or normal kidneys. COX-2 signals were low or undetectable in diseased kidneys, while normal kidneys showed clear positive signals in the macula densa (MD)...
September 13, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27758811/left-atrial-remodeling-and-atrioventricular-coupling-in-a-canine-model-of-early-heart-failure-with-preserved-ejection-fraction
#2
Rosita Zakeri, Gilles Moulay, Qiang Chai, Ozgur Ogut, Saad Hussain, Hiroyuki Takahama, Tong Lu, Xiao-Li Wang, Wolfgang A Linke, Hon-Chi Lee, Margaret M Redfield
BACKGROUND: Left atrial (LA) compliance and contractility influence left ventricular stroke volume. We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. METHODS AND RESULTS: Cardiac magnetic resonance imaging, echocardiography, left ventricular and LA pressure-volume studies, and tissue analyses were performed in a model of early HFpEF (elderly dogs, renal wrap-induced hypertension, exogenous aldosterone; n=9) and young control dogs (sham surgery; n=13)...
October 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27725349/evaluation-of-serum-cystatin-c-and-symmetric-dimethylarginine-concentrations-in-dogs-with-heart-failure-from-chronic-mitral-valvular-insufficiency
#3
Bum-Sul Choi, Hyeong-Sun Moon, Sang-Hyuk Seo, Changbaig Hyun
Reduction in glomerular filtration rate (GFR) is a common complication in advanced stages of heart failure (HF). The convenient and precise assessment for GFR would be useful for early detection of renal impairment in HF dogs. Our hypothesis of this study was the GFR would be reduced in advanced stages of HF from chronic mitral valvular disease (CMVI), as indicated by renal markers including serum cystatin-C (Cys-C) and symmetric dimethylarginine (SDMA) concentrations. Forty-three client-owned dogs consisting of 33 dogs with different stages of HF from CMVI and 10 age-matched healthy dogs were enrolled in this study...
September 30, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27717188/preliminary-investigation-of-cardiovascular-renal-disorders-in-dogs-with-chronic-mitral-valve-disease
#4
E Martinelli, C Locatelli, S Bassis, S Crosara, S Paltrinieri, P Scarpa, I Spalla, A M Zanaboni, C Quintavalla, P Brambilla
BACKGROUND: Veterinary literature lacks data about cardiovascular-renal disorders (CvRD) and cardiorenal-anemia syndrome (CRAS) in dogs. HYPOTHESIS: A direct correlation exists between ACVIM class and IRIS stage; chronic kidney disease (CKD) complicates chronic mitral valve disease (CMVD) more often than does anemia in dogs. ANIMALS: One hundred and fifty-eight client-owned dogs with CMVD. METHODS: Signalment, physical examination findings, electrocardiography, thoracic radiographs, echocardiography, and blood analysis were retrospectively evaluated to assess the prevalence of CKD and anemia in dogs with CMVD and to investigate the relationships among ACVIM class, IRIS stage, and survival...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27692098/effects-of-choline-treatment-in-concentrations-of-serum-matrix-metalloproteinases-mmps-mmp-tissue-inhibitors-timps-and-immunoglobulins-in-an-experimental-model-of-canine-sepsis
#5
Meric Kocaturk, Oya Eralp-Inan, A Tvarijonaviciute, Mehmet Cansev, M Ozgur Ozyigit, J J Ceron, Zeki Yilmaz, M Mufit Kahraman
The aim of the present study was to investigate effects of intravenous (i.v.) choline treatment on serum matrix metalloproteinases (MMP), MMP tissue inhibitors (TIMP) and immunoglobulins (Igs), and to determine if there were relations between serum MMPs/TIMPs and C-reactive protein (CRP) (as a marker of the acute phase response), immunoglobulin G and M (IgG and IgM) (as a maker of the Ig responses) and markers of organ damage such as muscular damage (creatine phosphokinase, [CPK]), liver damage (alanine aminotransferase [ALT]) and renal dysfunction (blood urea nitrogen [BUN] and creatinine, [Cr]) in dogs with endotoxemia...
November 1, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27641998/aspergillus-spp-panophthalmitis-with-intralenticular-invasion-in-dogs-report-of-two-cases
#6
Penelope J Wooff, Darryl D Dees, Leandro Teixeria
This case series describes the ocular, clinical and histologic manifestations of disseminated Aspergillosis in two dogs. Two dogs presented for severe unilateral panophthalmitis and secondary glaucoma with positive Aspergillus spp. titers. Case 1 showed no clinicopathologic systemic symptoms of fungal dissemination, however, case 2 was affected with acute renal failure. The affected eye of case 1 did not respond to medical therapy and was enucleated for comfort. The affected eye of case 2 responded to aggressive topical and systemic medical therapies, however, the patient was euthanized for acute renal failure...
September 19, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27595920/the-prevalence-of-dirofilaria-repens-in-cats-healthy-dogs-and-dogs-with-concurrent-babesiosis-in-an-expansion-zone-in-central-europe
#7
Anna Bajer, Anna Rodo, Ewa J Mierzejewska, Katarzyna Tołkacz, Renata Welc-Faleciak
BACKGROUND: Dirofilaria repens is a mosquito-transmitted, filarial nematode parasitizing dogs, cats and other carnivores. Recently, this parasite has spread in central Europe, including Poland. The aim of the present study was to estimate the prevalence of D. repens in cats and dogs in different regions of the country and to investigate the occurrence and consequences of co-infection with another fast-spreading vector-borne parasite, Babesia canis. RESULTS: In the period 2013-2015, 147 blood samples from cats from central Poland and 257 blood samples from dogs from central, northern, southern and western Poland were collected...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27555054/efficacy-and-safety-of-renal-sympathetic-denervation-on-dogs-with-pressure-overload-induced-heart-failure
#8
Pingan Chen, Shuilong Leng, Yishan Luo, Shaonan Li, Zicheng Huang, Zhenxi Liu, Zhen Liu, Jie Wang, Xiaoming Lei
BACKGROUND: In dogs with heart failure (HF) induced by overload pressure, the role of renal sympathetic denervation (RSD) on heart failure and in the renal artery is unclear. Therefore, we investigated the efficacy and safety of RSD in dogs with pressure overload-induced heart failure. METHODS: Twenty mongrel dogs were divided into a sham-operated group, an HF group and an HF + RSD group. In the sham-operated group, the abdominal aorta was located but was not constricted, in the HF group, the abdominal aorta was constricted without RSD, and the HF+RSD group underwent RSD with constriction of the abdominal aorta after 10 weeks...
July 26, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27543449/shaggy-lame-fox-syndrome-in-pribilof-island-arctic-foxes-alopex-lagopus-pribilofensis-alaska
#9
T R Spraker, P A White
A previously unrecognized condition is described in wild free-ranging Pribilof arctic foxes (Alopex lagopus pribilofensis) from the Pribilof Islands, Alaska, USA. This condition is called shaggy lame fox syndrome (SLFS) denoting the primary clinical signs first observed. Criteria used to suspect SLFS on gross examination included emaciation, failure to shed winter pelage and moderate to severe polyarthritis. Criteria used to confirm SLFS histologically included polyarthritis (characterized by lymphoplasmacytic synovitis, tenosynovitis, bursitis, periosteal bony proliferation, and periarticular lymphoplasmacytic vasculitis) and systemic leukocytoclastic vasculitis...
August 19, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27539305/risk-factors-for-invasive-pasteurellosis-a-retrospective-case-study
#10
V Nollet, L Souply, B Rosolen, M Mohseni-Zadeh, M Martinot
Pasteurellosis is a frequent zoonosis mainly transmitted by cats and dogs. Invasive forms of pasteurellosis are associated with significant morbidity and mortality. This retrospective study aimed to highlight risk factors (RFs) for invasive pasteurellosis. We included patients with positive Pasteurella samples. The clinical forms were classified as invasive or local pasteurellosis. We evaluated 13 RFs: age, sex, alcohol use, tobacco use, chronic liver disease, chronic renal failure, diabetes, chronic cardiovascular disease, chronic pulmonary disease, chronic inflammatory disease, chronic osteoarticular disease, immunosuppression, and progressive cancers...
August 18, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27510812/renal-failure-in-dogs-kept-by-a-man-with-severe-psoriasis
#11
Y Fujita, K Hanazono, E Uchida, T Kawahata, A Suto, K Nakamura, H Shimizu
Psoriasis is a common inflammatory disorder characterized by well-demarcated hyperkeratotic erythema and plaques. Topical vitamin D3 analogues are among the first-line treatments for psoriasis, and prescribed for 59.6% of psoriasis patients in Japan.(1) It is well-informed that topical application of vitamin D3 analogues can cause hypercalcemia in humans.(2) However, little is recognized by dermatologists that pets have a possibility to cause hypercalcemia, which are kept by psoriasis patients using topical vitamin D3 analogues...
August 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27487916/a-mixed-grape-and-blueberry-extract-is-safe-for-dogs-to-consume
#12
Anne-Sophie Martineau, Véronique Leray, Anne Lepoudere, Géraldine Blanchard, Julien Bensalem, David Gaudout, Khadija Ouguerram, Patrick Nguyen
BACKGROUND: Grape and blueberry extracts are known to protect against age-related cognitive decline. However, beneficial effects achieved by mixing grape and blueberry extracts have yet to be evaluated in dogs, or their bioavailability assessed. Of concern to us were cases of acute renal failure in dogs, after their ingestion of grapes or raisins. The European Pet Food Industry Federation (2013) considers only the grape or raisin itself to be potentially dangerous; grape-seed extracts per-se, are not considered to be a threat...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27432892/the-renal-outer-medullary-potassium-channel-inhibitor-mk-7145-lowers-blood-pressure-and-manifests-features-of-bartter-s-syndrome-type-ii-phenotype
#13
Caryn Hampton, Xiaoyan Zhou, Birgit T Priest, Lee-Yuh Pai, John P Felix, Brande Thomas-Fowlkes, Jessica Liu, Martin Kohler, Jianying Xiao, Aaron Corona, Olga Price, Charles Gill, Kashmira Shah, Cordelia Rasa, Vince Tong, Karen Owens, James Ormes, Haifeng Tang, Sophie Roy, Kathleen A Sullivan, Joseph M Metzger, Magdalena Alonso-Galicia, Gregory J Kaczorowski, Alexander Pasternak, Maria L Garcia
The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption and potassium secretion, and represents a target for the development of new mechanism of action diuretics. This idea is supported by the phenotype of antenatal Bartter's syndrome type II associated with loss-of-function mutations in the human ROMK channel, as well as, by cardiovascular studies of heterozygous carriers of channel mutations associated with type II Bartter's syndrome...
October 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27334828/hemostatic-assessment-of-dogs-associated-with-hepatic-parasite-load-of-leishmania-infantum-chagasi
#14
Mariana de Medeiros Torres, Arleana do Bom Parto Ferreira de Almeida, Daphine Ariadne Jesus de Paula, Adriane Jorge Mendonça, Luciano Nakazato, Caroline Argenta Pescador, Valéria Régia Franco Sousa
Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis...
June 14, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27304522/hemostatic-assessment-of-dogs-associated-with-hepatic-parasite-load-of-leishmania-infantum-chagasi
#15
Mariana de Medeiros Torres, Arleana do Bom Parto Ferreira de Almeida, Daphine Ariadne Jesus de Paula, Adriane Jorge Mendonça, Luciano Nakazato, Caroline Argenta Pescador, Valéria Régia Franco Sousa
Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis...
June 14, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27302674/pharmacokinetic-study-of-meropenem-in-healthy-beagle-dogs-receiving-intermittent-hemodialysis
#16
S Y Byun, J W Jeong, J H Choi, K P Lee, H Y Youn, H J Maeng, K H Song, T S Koo, K W Seo
Meropenem, a second carbapenem antimicrobial agent with a broad spectrum of activity, is used to treat sepsis and resistant-bacterial infections in veterinary medicine. The objective of this study was to identify the pharmacokinetics of meropenem in dogs receiving intermittent hemodialysis (IHD) and to determine the proper dosing in renal failure patients receiving IHD. Five healthy beagle dogs were given a single i.v. dose of 24 mg/kg of meropenem and received IHD. The blood flow rate, dialysate flow, and ultrafiltration rate were maintained at 40 mL/min, 300 mL/min, and 40 mL/h, respectively...
June 15, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27145686/ethylene-glycol-poisoning-in-three-dogs-importance-of-early-diagnosis-and-role-of-hemodialysis-as-a-treatment-option
#17
A Schweighauser, T Francey
Poisoning with ethylene glycol as contained in antifreeze can rapidly lead to irreversible acute renal failure and other organ damage. It carries a grave prognosis unless diagnosed early and adequate treatment is initiated within 8 hours of ingestion. Toxicity of ethylene glycol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), leading to early signs of severe polyuria (PU) and polydipsia (PD), gastritis, ataxia and central nervous depression, followed by progressive dehydration, and ultimately oligoanuric renal failure...
February 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27095981/dioctophyma-renale-goeze-1782-infection-in-a-domestic-dog-from-hamedan-western-iran
#18
Seyed Masoud Zolhavarieh, Alireza Norian, Morteza Yavari
Dioctophyma renale infection is found in a wide range of mammalian species, typically in temperate areas of the world. Here, we report for the first time, the parasitism of a domestic dog by D. renale in Hamedan, Iran, a mountainous cold region, lacking significant amounts of rainfall, high humidity and temperature. A 2.5 yr old male mixed breed dog was presented with a two months history of progressive hematuria and muscle weakness. Complete blood count and serum biochemistry were performed with results indicating impaired renal function...
January 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/26917550/x-linked-hereditary-nephropathy-in-navasota-dogs-clinical-pathology-morphology-and-gene-expression-during-disease-progression
#19
S L Benali, G E Lees, M B Nabity, A Aricò, M Drigo, E Gallo, M Giantin, L Aresu
X-linked hereditary nephropathy (XLHN) in Navasota dogs is a spontaneously occurring disease caused by a mutation resulting in defective production of type IV collagen and juvenile-onset renal failure. The study was aimed at examining the evolution of renal damage and the expression of selected molecules potentially involved in the pathogenesis of XLHN. Clinical data and renal samples were obtained in 10 XLHN male dogs and 5 controls at 4 (T0), 6 (T1), and 9 (T2) months of age. Glomerular and tubulointerstitial lesions were scored by light microscopy, and the expression of 21 molecules was investigated by quantitative real-time polymerase chain reaction with selected proteins evaluated by immunohistochemistry...
July 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/26839394/chronic-therapy-with-elamipretide-mtp-131-a-novel-mitochondria-targeting-peptide-improves-left-ventricular-and-mitochondrial-function-in-dogs-with-advanced-heart-failure
#20
Hani N Sabbah, Ramesh C Gupta, Smita Kohli, Mengjun Wang, Souheila Hachem, Kefei Zhang
BACKGROUND: Elamipretide (MTP-131), a novel mitochondria-targeting peptide, was shown to reduce infarct size in animals with myocardial infarction and improve renal function in pigs with acute and chronic kidney injury. This study examined the effects of chronic therapy with elamipretide on left ventricular (LV) and mitochondrial function in dogs with heart failure (HF). METHODS AND RESULTS: Fourteen dogs with microembolization-induced HF were randomized to 3 months monotherapy with subcutaneous injections of elamipretide (0...
February 2016: Circulation. Heart Failure
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