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Canine kidney failure

Dagmara Winiarczyk, Łukasz Adaszek, Michał Bartnicki, Beata Abramowicz, Paweł Łyp, Jacek Madany, Stanisław Winiarczyk
OBJECTIVE: Canine babesiosis is a common and clinically significant tick-borne disease caused by haemoprotozoan parasites of the genus Babesia. Acute renal failure is considered to be one of the most prevalent complications of canine babesiosis. This complication leads to a decrease in the glomerular filtration rate and in consequence causes azotemia and uremia. The objective of this study was to assess the localization and extent of renal damage in dogs infected with Babesia canis using an urinary marker for glomerular (urinary immunoglobulin G, uIgG), proximal tubular dysfunction (urinary retinol binding protein, uRBP) and distal tubular dysfunction (urinary Tamm-Horsfal protein, uTHP)...
January 11, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Ping Xu, Zhao-Li Ling, Ji Zhang, Ying Li, Nan Shu, Ze-Yu Zhong, Yang Chen, Xin-Yu Di, Zhong-Jian Wang, Li Liu, Xiao-Dong Liu
AIM: Liver failure is associated with dyshomeostasis of efflux transporters at the blood-brain barrier (BBB), which contributes to hepatic encephalopathy. In this study we examined whether breast cancer resistance protein (BCRP), a major efflux transporter at the BBB, was altered during liver failure in rats. METHODS: Rats underwent bile duct ligation (BDL) surgery, and then were sacrificed after intravenous injection of prazosin on d3, d7 and d14. The brains and blood samples were collected...
August 2016: Acta Pharmacologica Sinica
Takashi Iijima, Junichi Hoshino, Koki Mise, Keiichi Sumida, Tatsuya Suwabe, Noriko Hayami, Toshiharu Ueno, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Naoya Morisada, Kazumoto Iijima, Yoshifumi Ubara
A 35-year-old woman was admitted to our hospital for evaluation of end-stage renal failure. Diagnostic imaging, including ultrasonography and magnetic resonance imaging, showed polycystic kidneys and peribiliary hepatic cysts, but the renal cysts were isointense and her kidneys were smaller than the end-stage kidneys of patients with autosomal dominant polycystic kidney disease. Glomerulocystic kidney disease was diagnosed by renal biopsy. Clinical examination revealed findings such as a missing maxillary canine, lingual anomalies, and brachydactyly...
September 2016: Human Pathology
Elnaz Gozalpour, Martijn J Wilmer, Albert Bilos, Rosalinde Masereeuw, Frans G M Russel, Jan B Koenderink
Digitalis-like compounds (DLCs), the ancient medication of heart failure and Na,K-ATPase inhibitors, are characterized by their toxicity. Drug-drug interactions (DDIs) at absorption and excretion levels play a key role in their toxicity, hence, knowledge about the transporters involved might prevent these unwanted interactions. In the present study, the transport of fourteen DLCs with human P-glycoprotein (P-gp; ABCB1) was studied using a liquid chromatography-mass spectrometry (LC-MS) quantification method...
April 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Nethaji Lokeswar Oburai, V Vaikunta Rao, Ram Babu Naik Bonath
BACKGROUND: Complementing herbal drugs with conservative modern treatment could improve renal condition in canine chronic renal failure (CRF). OBJECTIVE: In this study, clinical evaluation of Boerhavia diffusa root extract was carried out in CRF in dogs in comparison with standard enalapril. MATERIALS AND METHODS: A total of 20 dogs of mixed breeds suffering from CRF from 1 to 2 months were divided into two groups (n = 10) and treated as follows: Group I - Enalapril at 0...
July 2015: Journal of Ayurveda and Integrative Medicine
Hsin-Yi Shyu, Chun-Jung Ko, Yu-Chen Luo, Hsin-Ying Lin, Shang-Ru Wu, Shao-Wei Lan, Tai-Shan Cheng, Shih-Hsiung Hu, Ming-Shyue Lee
Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous effects, including renal failure; however, the underlying mechanism is poorly understood. The process called epithelial phenotypic changes (EPCs) causes the loss of cell-cell adhesion and cell polarity in renal diseases, as well as the acquisition of migratory and invasive properties. Madin-Darby canine kidney cells, an in vitro cell model, were subjected to experimental manipulation to investigate whether ketamine could promote EPCs...
April 2016: Journal of Cellular Biochemistry
Tomoko Ichiki, Brenda K Huntley, S Jeson Sangaralingham, John C Burnett
OBJECTIVES: The aim of this study was to determine if the atrial natriuretic peptide (ANP) precursor proANP is biologically active compared with ANP and B-type natriuretic peptide (BNP). BACKGROUND: ProANP is produced in the atria and processed to ANP and activates the guanylyl cyclase receptor-A (GC-A) and its second messenger, cyclic guanosine monophosphate (cGMP). ProANP is found in the human circulation, but its bioavailability is undefined. METHODS: The in vivo actions of proANP compared with ANP, BNP, and placebo were investigated in normal canines (667 pmol/kg, n = 5/group)...
September 2015: JACC. Heart Failure
L Kiczak, E Wałecka-Zacharska, J Bania, I Sambor, T Stefaniak, P Dzięgiel, M Zacharski, A Tomaszek, I Rybińska, U Pasławska
The IL-1β gene can be also be spliced with the intron 4 retention; the result is a IL-1β splice variant 1 (IL-1βsv1), which was significantly up-regulated in failing myocardium of dogs suffering from chronic degenerative valvular disease (CDVD). Expression of IL-1βsv1 was assessed, at both RNA and protein levels, in organs affected by heart failure, namely, kidneys, liver, and lungs from 35 dogs suffering chronic degenerative valvular disease (CDVD) and in 20 disease free control dogs. IL-1βsv1 RNA was detected in the dogs from both groups...
October 15, 2015: Veterinary Immunology and Immunopathology
Kevin J Esch, Robert G Schaut, Ian M Lamb, Gwendolyn Clay, Ádila L Morais Lima, Paulo R P do Nascimento, Elizabeth M Whitley, Selma M B Jeronimo, Fayyaz S Sutterwala, Joseph S Haynes, Christine A Petersen
Chronic kidney disease is a major contributor to human and companion animal morbidity and mortality. Renal complications are sequelae of canine and human visceral leishmaniasis (VL). Despite the high incidence of infection-mediated glomerulonephritis, little is known about pathogenesis of VL-associated renal disease. Leishmania infantum-infected dogs are a naturally occurring model of VL-associated glomerulonephritis. Membranoproliferative glomerulonephritis type I [24 of 25 (96%)], with interstitial lymphoplasmacytic nephritis [23 of 25 (92%)], and glomerular and interstitial fibrosis [12 of 25 (48%)] were predominant lesions...
August 2015: American Journal of Pathology
Genya Izawa, Wakako Kobayashi, Misako Haraguchi, Akiharu Sudo, Masayuki Ozawa
Epithelial-mesenchymal transition (EMT), a key process in the tumor metastatic cascade, is characterized by the loss of cell-cell junctions and cell polarity, as well as by the acquisition of migratory and invasive properties. However, the precise molecular events that initiate this complex EMT process are poorly understood. Snail expression induces EMT in Madin-Darby canine kidney (MDCK) cells and the human epidermoid carcinoma cell line, A431. Snail is a zinc finger transcription factor and triggers EMT by suppressing E-cadherin expression...
July 2015: International Journal of Molecular Medicine
Jennifer M Herring, Maureen A McMichael, Raffaella Corsi, Virginie Wurlod
OBJECTIVE: To report a case series of canine naproxen overdoses successfully treated with intravenous lipid emulsion therapy (IVLE). SERIES SUMMARY: Three dogs were presented for acute ingestion of naproxen and were treated with IVLE. Baseline and post treatment serum naproxen concentrations were measured. The first exposure involved ingestion of 61 mg/kg of an over-the-counter naproxen formulation in a 7-month-old male intact Labrador Retriever. Pre-IVLE toxin concentration assessed by high performance liquid chromatography (HPLC) was 73 μg/mL with a one-hour post-IVLE concentration decreasing to 30 μg/mL...
September 2015: Journal of Veterinary Emergency and Critical Care
R Rørtveit, M R Reiten, F Lingaas, S B Sveri, A Brech, A Espenes, J H Jansen
Collagen type III glomerulopathy, also known as collagenofibrotic glomerulopathy, is a rare renal disease of unknown pathogenesis. The disease occurs in humans and animals and is characterized by massive glomerular accumulations of collagen type III. In the present study, we describe a Drever dog litter affected by an early onset variant of this glomerular disease, where 4 of 9 puppies developed renal failure within 50 days of age. Necropsy specimens of kidney from the 4 affected cases were studied by light microscopy, electron microscopy, and immunohistochemistry, and characteristic lesions compatible with a diagnosis of collagen type III glomerulopathy were found...
November 2015: Veterinary Pathology
Davide Rolla, Novella Conti, Francesca Ansaldo, Laura Panaro, Tiziano Lusenti
INTRODUCTION: We report a case of a patient with acute renal failure in Lyme disease-associated focal proliferative mesangial nephropathy. Lyme disease is a vector-borne disease caused by Borrelia burgdorferi, transmitted by the bite of an infected ixodes tick. Post-infectious glomerulonephritis (GN)secondary to Borrelia burgdorferi infection in man could be fatal, as it is in canine Lyme borreliosis. CASE: A 61-year old man with chronic ethanolic hepatitis was admitted to a provincial hospital, complaining of nausea, diarrhoea and loss of his sense of taste...
2014: Journal of Renal Injury Prevention
Meng He, Khadar M Abdi, Vann Bennett
Ankyrin-G and βII-spectrin colocalize at sites of cell-cell contact in columnar epithelial cells and promote lateral membrane assembly. This study identifies two critical inputs from lipids that together provide a rationale for how ankyrin-G and βII-spectrin selectively localize to Madin-Darby canine kidney (MDCK) cell lateral membranes. We identify aspartate-histidine-histidine-cysteine 5/8 (DHHC5/8) as ankyrin-G palmitoyltransferases required for ankyrin-G lateral membrane localization and for assembly of lateral membranes...
July 21, 2014: Journal of Cell Biology
Pengyuan Sun, Changyuan Wang, Qi Liu, Qiang Meng, Aijie Zhang, Xiaokui Huo, Huijun Sun, Kexin Liu
BACKGROUND: Eprosartan is an angiotensin II receptor antagonist, used in the treatment of hypertension and heart failure in clinical patients. The objective of this study was to clarify the mechanism underlying hepatic uptake and biliary excretion of eprosartan in rats and humans. METHODS: Perfused rat liver in situ, rat liver slices, isolated rat hepatocytes and human organic anion-transporting polypeptide (OATP)-transfected cells in vitro were used in this study...
April 2014: Pharmacological Reports: PR
Yukiko Muramoto, Jason E Shoemaker, Mai Quynh Le, Yasushi Itoh, Daisuke Tamura, Yuko Sakai-Tagawa, Hirotaka Imai, Ryuta Uraki, Ryo Takano, Eiryo Kawakami, Mutsumi Ito, Kiyoko Okamoto, Hirohito Ishigaki, Hitomi Mimuro, Chihiro Sasakawa, Yukiko Matsuoka, Takeshi Noda, Satoshi Fukuyama, Kazumasa Ogasawara, Hiroaki Kitano, Yoshihiro Kawaoka
UNLABELLED: Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans causes severe pneumonia with high mortality. To better understand the mechanisms via which H5N1 viruses induce severe disease in humans, we infected cynomolgus macaques with six different H5N1 strains isolated from human patients and compared their pathogenicity and the global host responses to the virus infection. Although all H5N1 viruses replicated in the respiratory tract, there was substantial heterogeneity in their replicative ability and in the disease severity induced, which ranged from asymptomatic to fatal...
August 2014: Journal of Virology
Ruifeng Lu, Debra L Johnson, Lorraine Stewart, Kelsey Waite, David Elliott, Jean M Wilson
Regulation of epithelial barrier function requires targeted insertion of tight junction proteins that have distinct selectively permeable characteristics. The insertion of newly synthesized proteins and recycling of internalized tight junction components control both polarity and junction function. Here we show that the small GTPase Rab14 regulates tight junction structure. In Madin-Darby canine kidney (MDCK) II cells, Rab14 colocalizes with junctional proteins, and knockdown of Rab14 results in increased transepithelial resistance...
June 2014: Molecular Biology of the Cell
Wojciech Zygner, Olga Gójska-Zygner, Piotr Bąska, Ewa Długosz
Canine babesiosis is a tick-borne disease caused by parasites of the genus Babesia. Tumour necrosis factor alpha (TNF-α) is a cytokine that plays a role in the pathogenesis of canine babesiosis. In this study, the authors determined the concentration of serum TNF-α in 11 dogs infected with Babesia canis and calculated Spearman's rank correlations between the concentration of TNF-α and blood pressure, and between TNF-α and indices of renal damage such as: fractional excretion of sodium (FE(Na(+))), urinary creatinine to serum creatinine ratio (UCr/SCr), renal failure index (RFI), urine specific gravity (USG) and urinary protein to urinary creatinine ratio (UPC)...
April 2014: Parasitology Research
Chaowalit Yuajit, Chatchai Muanprasat, Anna-Rachel Gallagher, Sorin V Fedeles, Suticha Kittayaruksakul, Sureeporn Homvisasevongsa, Stefan Somlo, Varanuj Chatsudthipong
Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) is associated with cAMP-activated proliferation of cyst-lining epithelial cells and transepithelial fluid secretion into the cyst lumen via cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel leading to renal failure for which no effective treatment is currently available. We previously reported that steviol retards Madin-Darby canine kidney (MDCK) cyst enlargement by inhibiting CFTR channel activity and promoting proteasomal-mediated CFTR degradation...
April 1, 2014: Biochemical Pharmacology
Kuang-Wei Lin, Yohan Kim, Adam D Maxwell, Tzu-Yin Wang, Timothy L Hall, Zhen Xu, J Brian Fowlkes, Charles A Cain
Histotripsy produces tissue fractionation through dense energetic bubble clouds generated by short, high-pressure, ultrasound pulses. Conventional histotripsy treatments have used longer pulses from 3 to 10 cycles, wherein the lesion-producing bubble cloud generation depends on the pressure-release scattering of very high peak positive shock fronts from previously initiated, sparsely distributed bubbles (the shock-scattering mechanism). In our recent work, the peak negative pressure (P-) for generation of dense bubble clouds directly by a single negative half cycle, the intrinsic threshold, was measured...
February 2014: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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