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Dog kidney failure

E Martinelli, C Locatelli, S Bassis, S Crosara, S Paltrinieri, P Scarpa, I Spalla, A M Zanaboni, C Quintavalla, P Brambilla
BACKGROUND: Veterinary literature lacks data about cardiovascular-renal disorders (CvRD) and cardiorenal-anemia syndrome (CRAS) in dogs. HYPOTHESIS: A direct correlation exists between ACVIM class and IRIS stage; chronic kidney disease (CKD) complicates chronic mitral valve disease (CMVD) more often than does anemia in dogs. ANIMALS: One hundred and fifty-eight client-owned dogs with CMVD. METHODS: Signalment, physical examination findings, electrocardiography, thoracic radiographs, echocardiography, and blood analysis were retrospectively evaluated to assess the prevalence of CKD and anemia in dogs with CMVD and to investigate the relationships among ACVIM class, IRIS stage, and survival...
September 2016: Journal of Veterinary Internal Medicine
T R Spraker, P A White
A previously unrecognized condition is described in wild free-ranging Pribilof arctic foxes (Alopex lagopus pribilofensis) from the Pribilof Islands, Alaska, USA. This condition is called shaggy lame fox syndrome (SLFS) denoting the primary clinical signs first observed. Criteria used to suspect SLFS on gross examination included emaciation, failure to shed winter pelage and moderate to severe polyarthritis. Criteria used to confirm SLFS histologically included polyarthritis (characterized by lymphoplasmacytic synovitis, tenosynovitis, bursitis, periosteal bony proliferation, and periarticular lymphoplasmacytic vasculitis) and systemic leukocytoclastic vasculitis...
August 19, 2016: Veterinary Pathology
Seyed Masoud Zolhavarieh, Alireza Norian, Morteza Yavari
Dioctophyma renale infection is found in a wide range of mammalian species, typically in temperate areas of the world. Here, we report for the first time, the parasitism of a domestic dog by D. renale in Hamedan, Iran, a mountainous cold region, lacking significant amounts of rainfall, high humidity and temperature. A 2.5 yr old male mixed breed dog was presented with a two months history of progressive hematuria and muscle weakness. Complete blood count and serum biochemistry were performed with results indicating impaired renal function...
January 2016: Iranian Journal of Parasitology
Clark Kensinger, Seth Karp, Rishi Kant, Benjamin W Chui, Kenneth Goldman, Torin Yeager, Edward R Gould, Amanda Buck, David C Laneve, Joseph J Groszek, Shuvo Roy, William H Fissell
An implantable hemofilter for the treatment of kidney failure depends critically on the transport characteristics of the membrane and the biocompatibility of the membrane, cartridge, and blood conduits. A novel membrane with slit-shaped pores optimizes the trade-off between permeability and selectivity, enabling implanted therapy. Sustained (3-8) day function of an implanted parallel-plate hemofilter with minimal anticoagulation was achieved by considering biocompatibility at the subnanometer scale of chemical interactions and the millimeter scale of blood fluid dynamics...
July 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Umit Karademir, Dilek Aksit, Cavit Kum, Hasan Erdogan, Eyup Hakan Ucar, Cevdet Peker, Cengiz Gokbulut
BACKGROUND: Meloxicam (MLX) is a nonsteroidal anti-inflammatory drug used in the relief of postoperative pain for human and veterinary medicine. This study was designed to investigate the effect of surgery on the plasma disposition of MLX in dogs undergoing ovariohysterectomy following a single intravenous injection at a dose of 0.2 mg/kg bodyweight. Eight crossbred bitches were used in the study. A two-phase experimental design with a 10-day washout period was used. Pre-operative MLX was administered intravenously to 8 bitches about 10 days before surgery (Phase I, control) at a dose of 0...
2016: BMC Veterinary Research
Hani N Sabbah, Ramesh C Gupta, Smita Kohli, Mengjun Wang, Souheila Hachem, Kefei Zhang
BACKGROUND: Elamipretide (MTP-131), a novel mitochondria-targeting peptide, was shown to reduce infarct size in animals with myocardial infarction and improve renal function in pigs with acute and chronic kidney injury. This study examined the effects of chronic therapy with elamipretide on left ventricular (LV) and mitochondrial function in dogs with heart failure (HF). METHODS AND RESULTS: Fourteen dogs with microembolization-induced HF were randomized to 3 months monotherapy with subcutaneous injections of elamipretide (0...
February 2016: Circulation. Heart Failure
Nethaji Lokeswar Oburai, V Vaikunta Rao, Ram Babu Naik Bonath
BACKGROUND: Complementing herbal drugs with conservative modern treatment could improve renal condition in canine chronic renal failure (CRF). OBJECTIVE: In this study, clinical evaluation of Boerhavia diffusa root extract was carried out in CRF in dogs in comparison with standard enalapril. MATERIALS AND METHODS: A total of 20 dogs of mixed breeds suffering from CRF from 1 to 2 months were divided into two groups (n = 10) and treated as follows: Group I - Enalapril at 0...
July 2015: Journal of Ayurveda and Integrative Medicine
L Kiczak, E Wałecka-Zacharska, J Bania, I Sambor, T Stefaniak, P Dzięgiel, M Zacharski, A Tomaszek, I Rybińska, U Pasławska
The IL-1β gene can be also be spliced with the intron 4 retention; the result is a IL-1β splice variant 1 (IL-1βsv1), which was significantly up-regulated in failing myocardium of dogs suffering from chronic degenerative valvular disease (CDVD). Expression of IL-1βsv1 was assessed, at both RNA and protein levels, in organs affected by heart failure, namely, kidneys, liver, and lungs from 35 dogs suffering chronic degenerative valvular disease (CDVD) and in 20 disease free control dogs. IL-1βsv1 RNA was detected in the dogs from both groups...
October 15, 2015: Veterinary Immunology and Immunopathology
Gary Gabriels, Mike Lambert, Pete Smith, Lubbe Wiesner, Donavon Hiss
BACKGROUND: Nutritional supplements are used or experimented with by consumers, notably these are; competitive and recreational athletes of all ages, and 'weekend warriors'. As a consequence the supplement industry has grown to meet the increasing demand. A Global Industry Analysts Inc. report indicates that the herbal supplement market has not declined during the worldwide recession, but in fact exhibited steady growth over the period 2008 to 2009. It is anticipated that the market will reach US$93...
2015: Nutrition Journal
Kevin J Esch, Robert G Schaut, Ian M Lamb, Gwendolyn Clay, Ádila L Morais Lima, Paulo R P do Nascimento, Elizabeth M Whitley, Selma M B Jeronimo, Fayyaz S Sutterwala, Joseph S Haynes, Christine A Petersen
Chronic kidney disease is a major contributor to human and companion animal morbidity and mortality. Renal complications are sequelae of canine and human visceral leishmaniasis (VL). Despite the high incidence of infection-mediated glomerulonephritis, little is known about pathogenesis of VL-associated renal disease. Leishmania infantum-infected dogs are a naturally occurring model of VL-associated glomerulonephritis. Membranoproliferative glomerulonephritis type I [24 of 25 (96%)], with interstitial lymphoplasmacytic nephritis [23 of 25 (92%)], and glomerular and interstitial fibrosis [12 of 25 (48%)] were predominant lesions...
August 2015: American Journal of Pathology
M B Nabity, G E Lees, M M Boggess, M Yerramilli, E Obare, M Yerramilli, A Rakitin, J Aguiar, R Relford
BACKGROUND: Symmetric dimethylarginine (SDMA) is a small molecule formed by methylation of arginine, and released into blood during protein degradation. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate (GFR). OBJECTIVES: To validate an assay for SDMA measurement, determine stability of SDMA in blood, and compare SDMA with serum creatinine concentration (sCr) and GFR for early detection of decreasing kidney function in dogs with chronic kidney disease (CKD)...
July 2015: Journal of Veterinary Internal Medicine
Jennifer M Herring, Maureen A McMichael, Raffaella Corsi, Virginie Wurlod
OBJECTIVE: To report a case series of canine naproxen overdoses successfully treated with intravenous lipid emulsion therapy (IVLE). SERIES SUMMARY: Three dogs were presented for acute ingestion of naproxen and were treated with IVLE. Baseline and post treatment serum naproxen concentrations were measured. The first exposure involved ingestion of 61 mg/kg of an over-the-counter naproxen formulation in a 7-month-old male intact Labrador Retriever. Pre-IVLE toxin concentration assessed by high performance liquid chromatography (HPLC) was 73 μg/mL with a one-hour post-IVLE concentration decreasing to 30 μg/mL...
September 2015: Journal of Veterinary Emergency and Critical Care
Behnam Pedram, Ahmad Taghavi Moghadam, Zahra Kamyabi-Moghaddam, Omid Mavedati, Babak Abbas Beigi, Adel Khodaei Sharabiyani, Ali Bashiri Dezfuli, Soheil Khalili, Ali Mohammad Bahrami, Alireza Nasoori
Cisplatin (CP) is a remarkably effective Pt-based anticancer drug, but it also exhibits severe toxic side effects, including nephrotoxicity and ototoxicity, and CP nephrotoxicity is a major constraint for the treatment of solid tumors. This study was designed to evaluate the electrolyte and biochemical changes in dogs with acute kidney injury (acute renal failure) following administration of CP as a chemotherapeutic agent to exhibit broad efficacy in solid tumors. A total of 10 adult male dogs were selected (treated dogs = 7 and control dogs = 3)...
June 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Gultekin Genctoy, Serap Arikan, Olcay Gedik
PURPOSE: Hyperparathyroidism is associated with pulmonary vascular calcification and pulmonary hypertension (PH) in a chronic kidney failure dog model, and increased prevalence of PH and a PH-hyperparathyroidism relationship in pre-dialysis chronic kidney disease (CKD) and hemodialysis patients are reported. This study investigated the prevalence of PH and relationships between PH and metabolic abnormalities in patients with stage 1-4 proteinuria CKD. METHODS: One-hundred and ninety patients (mean age 61 ± 17...
February 2015: International Urology and Nephrology
R Rørtveit, M R Reiten, F Lingaas, S B Sveri, A Brech, A Espenes, J H Jansen
Collagen type III glomerulopathy, also known as collagenofibrotic glomerulopathy, is a rare renal disease of unknown pathogenesis. The disease occurs in humans and animals and is characterized by massive glomerular accumulations of collagen type III. In the present study, we describe a Drever dog litter affected by an early onset variant of this glomerular disease, where 4 of 9 puppies developed renal failure within 50 days of age. Necropsy specimens of kidney from the 4 affected cases were studied by light microscopy, electron microscopy, and immunohistochemistry, and characteristic lesions compatible with a diagnosis of collagen type III glomerulopathy were found...
November 2015: Veterinary Pathology
Davide Rolla, Novella Conti, Francesca Ansaldo, Laura Panaro, Tiziano Lusenti
INTRODUCTION: We report a case of a patient with acute renal failure in Lyme disease-associated focal proliferative mesangial nephropathy. Lyme disease is a vector-borne disease caused by Borrelia burgdorferi, transmitted by the bite of an infected ixodes tick. Post-infectious glomerulonephritis (GN)secondary to Borrelia burgdorferi infection in man could be fatal, as it is in canine Lyme borreliosis. CASE: A 61-year old man with chronic ethanolic hepatitis was admitted to a provincial hospital, complaining of nausea, diarrhoea and loss of his sense of taste...
2014: Journal of Renal Injury Prevention
Ariane Schweighauser, Iwan A Burgener, Frédéric Gaschen, Nicole Luckschander, Andreas Hasler, Johann Lang, Thierry Francey
OBJECTIVES: This case series describes 5 dogs with small intestinal intussusception and acute kidney injury due to infection with Leptospira interrogans serovar Australis. CASE SERIES SUMMARY: Small intestinal intussusception was observed in 4 dogs diagnosed with acute kidney injury due to leptospirosis presented between 1997 and 2005. Intussusception was diagnosed at initial presentation or later during hospitalization. An additional dog fulfilling our inclusion criteria was presented to a small animal specialty clinic nearby and was included...
August 2009: Journal of Veterinary Emergency and Critical Care
Angela Borchers, Steven E Epstein, Blaz Gindiciosi, Andrew Cartoceti, Birgit Puschner
Manganese is a ubiquitous, essential trace element and a common ingredient of joint supplement tablets. Little information is known about the inherent toxic potential if ingested at higher doses. A 5-year-old female spayed Pug dog presented for evaluation of vomiting and ataxia after accidental ingestion of approximately 100 joint supplement tablets. The dog developed acute hepatic failure and was euthanized 6 days after presentation due to progression of the disease. Necropsy showed severe acute hepatic necrosis...
September 2014: Journal of Veterinary Diagnostic Investigation
Yukiko Muramoto, Jason E Shoemaker, Mai Quynh Le, Yasushi Itoh, Daisuke Tamura, Yuko Sakai-Tagawa, Hirotaka Imai, Ryuta Uraki, Ryo Takano, Eiryo Kawakami, Mutsumi Ito, Kiyoko Okamoto, Hirohito Ishigaki, Hitomi Mimuro, Chihiro Sasakawa, Yukiko Matsuoka, Takeshi Noda, Satoshi Fukuyama, Kazumasa Ogasawara, Hiroaki Kitano, Yoshihiro Kawaoka
UNLABELLED: Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans causes severe pneumonia with high mortality. To better understand the mechanisms via which H5N1 viruses induce severe disease in humans, we infected cynomolgus macaques with six different H5N1 strains isolated from human patients and compared their pathogenicity and the global host responses to the virus infection. Although all H5N1 viruses replicated in the respiratory tract, there was substantial heterogeneity in their replicative ability and in the disease severity induced, which ranged from asymptomatic to fatal...
August 2014: Journal of Virology
Karen M Tefft, Darcy H Shaw, Sherri L Ihle, Shelley A Burton, LeeAnn Pack
BACKGROUND: Markedly overweight people can develop progressive proteinuria and kidney failure secondary to obesity-related glomerulopathy (ORG). Glomerular lesions in dogs with experimentally induced obesity are similar to those in people with ORG. OBJECTIVES: The aim of this study was to evaluate if urine protein and albumin excretion is greater in overweight and obese dogs than in dogs of ideal body condition. METHODS: Client-owned dogs were screened for underlying health conditions...
June 2014: Veterinary Clinical Pathology
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