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Canine renal failure

Anita Y Chhabra, Joseph Leventhal, Andrea R Merchak, Suzanne Ildstad
Renal transplantation has become the preferred treatment for end stage kidney failure. Although short-term graft survival has significantly improved as advances in immunosuppression have occurred, long term patient and graft survival have not. Approximately only 50% of renal transplant recipients are alive at 10 years due to the toxicities of immunosuppression and alloimmunity. Emerging research on cell-based therapies is opening a new door for patients to receive the organs they need without sacrificing quality of life and longevity because of drug based immunosuppression...
June 1, 2017: Transplantation
Tomoko Ichiki, Brenda K Huntley, Gail J Harty, S Jeson Sangaralingham, John C Burnett
Heart failure (HF) is a major health problem with worsening outcomes when renal impairment is present. Therapeutics for early phase HF may be effective for cardiorenal protection, however the detailed characteristics of the kidney in early-stage HF (ES-HF), and therefore treatment for potential renal protection, are poorly defined. We sought to determine the gene and protein expression profiles of specific maladaptive pathways of ES-HF in the kidney and heart. Experimental canine ES-HF, characterized by de-novo HF with atrial remodeling but not ventricular fibrosis, was induced by right ventricular pacing for 10 days...
May 2017: Physiological Reports
Qian Yin, Dana Abendschein, David Muccigrosso, Robert O'Connor, Thomas Goldstein, Ridong Chen, Jie Zheng
PURPOSE: Safe, sensitive, and non-invasive imaging methods to assess the presence, extent, and turnover of myocardial fibrosis are needed for early stratification of risk in patients who might develop heart failure after myocardial infarction. We describe a non-contrast cardiac magnetic resonance (CMR) approach for sensitive detection of myocardial fibrosis using a canine model of myocardial infarction and reperfusion. METHODS: Seven dogs had coronary thrombotic occlusion of the left anterior descending coronary arteries followed by fibrinolytic reperfusion...
April 28, 2017: Magnetic Resonance Imaging
June H Williams, Zandri Whitehead, Erna Van Wilpe
Paraquat is a bipyridylium non-selective contact herbicide commonly used worldwide. When ingestion occurs by humans and animals either accidentally, intentionally or maliciously, paraquat selectively accumulates in the lungs resulting in the production of oxygen-free radicals, causing membrane damage and cell death. Intoxicated subjects typically show progressive and fatal pulmonary haemorrhage, collapse and oedema. In individuals surviving the acute phase, pulmonary fibrosis develops. Gastrointestinal-, renal- and central nervous system clinical signs may also occur...
November 9, 2016: Journal of the South African Veterinary Association
Dagmara Winiarczyk, Łukasz Adaszek, Michał Bartnicki, Beata Abramowicz, Paweł Łyp, Jacek Madany, Stanisław Winiarczyk
OBJECTIVE: Canine babesiosis is a common and clinically significant tick-borne disease caused by haemoprotozoan parasites of the genus Babesia. Acute renal failure is considered to be one of the most prevalent complications of canine babesiosis. This complication leads to a decrease in the glomerular filtration rate and in consequence causes azotemia and uremia. The objective of this study was to assess the localization and extent of renal damage in dogs infected with Babesia canis using an urinary marker for glomerular (urinary immunoglobulin G, uIgG), proximal tubular dysfunction (urinary retinol binding protein, uRBP) and distal tubular dysfunction (urinary Tamm-Horsfal protein, uTHP)...
April 19, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Rosita Zakeri, Gilles Moulay, Qiang Chai, Ozgur Ogut, Saad Hussain, Hiroyuki Takahama, Tong Lu, Xiao-Li Wang, Wolfgang A Linke, Hon-Chi Lee, Margaret M Redfield
BACKGROUND: Left atrial (LA) compliance and contractility influence left ventricular stroke volume. We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. METHODS AND RESULTS: Cardiac magnetic resonance imaging, echocardiography, left ventricular and LA pressure-volume studies, and tissue analyses were performed in a model of early HFpEF (elderly dogs, renal wrap-induced hypertension, exogenous aldosterone; n=9) and young control dogs (sham surgery; n=13)...
October 2016: Circulation. Heart Failure
Meric Kocaturk, Oya Eralp-Inan, A Tvarijonaviciute, Mehmet Cansev, M Ozgur Ozyigit, J J Ceron, Zeki Yilmaz, M Mufit Kahraman
The aim of the present study was to investigate effects of intravenous (i.v.) choline treatment on serum matrix metalloproteinases (MMP), MMP tissue inhibitors (TIMP) and immunoglobulins (Igs), and to determine if there were relations between serum MMPs/TIMPs and C-reactive protein (CRP) (as a marker of the acute phase response), immunoglobulin G and M (IgG and IgM) (as a maker of the Ig responses) and markers of organ damage such as muscular damage (creatine phosphokinase, [CPK]), liver damage (alanine aminotransferase [ALT]) and renal dysfunction (blood urea nitrogen [BUN] and creatinine, [Cr]) in dogs with endotoxemia...
November 1, 2016: Veterinary Immunology and Immunopathology
Anna Bajer, Anna Rodo, Ewa J Mierzejewska, Katarzyna Tołkacz, Renata Welc-Faleciak
BACKGROUND: Dirofilaria repens is a mosquito-transmitted, filarial nematode parasitizing dogs, cats and other carnivores. Recently, this parasite has spread in central Europe, including Poland. The aim of the present study was to estimate the prevalence of D. repens in cats and dogs in different regions of the country and to investigate the occurrence and consequences of co-infection with another fast-spreading vector-borne parasite, Babesia canis. RESULTS: In the period 2013-2015, 147 blood samples from cats from central Poland and 257 blood samples from dogs from central, northern, southern and western Poland were collected...
September 5, 2016: BMC Veterinary Research
Takashi Iijima, Junichi Hoshino, Koki Mise, Keiichi Sumida, Tatsuya Suwabe, Noriko Hayami, Toshiharu Ueno, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Naoya Morisada, Kazumoto Iijima, Yoshifumi Ubara
A 35-year-old woman was admitted to our hospital for evaluation of end-stage renal failure. Diagnostic imaging, including ultrasonography and magnetic resonance imaging, showed polycystic kidneys and peribiliary hepatic cysts, but the renal cysts were isointense and her kidneys were smaller than the end-stage kidneys of patients with autosomal dominant polycystic kidney disease. Glomerulocystic kidney disease was diagnosed by renal biopsy. Clinical examination revealed findings such as a missing maxillary canine, lingual anomalies, and brachydactyly...
September 2016: Human Pathology
Elnaz Gozalpour, Martijn J Wilmer, Albert Bilos, Rosalinde Masereeuw, Frans G M Russel, Jan B Koenderink
Digitalis-like compounds (DLCs), the ancient medication of heart failure and Na,K-ATPase inhibitors, are characterized by their toxicity. Drug-drug interactions (DDIs) at absorption and excretion levels play a key role in their toxicity, hence, knowledge about the transporters involved might prevent these unwanted interactions. In the present study, the transport of fourteen DLCs with human P-glycoprotein (P-gp; ABCB1) was studied using a liquid chromatography-mass spectrometry (LC-MS) quantification method...
April 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Nethaji Lokeswar Oburai, V Vaikunta Rao, Ram Babu Naik Bonath
BACKGROUND: Complementing herbal drugs with conservative modern treatment could improve renal condition in canine chronic renal failure (CRF). OBJECTIVE: In this study, clinical evaluation of Boerhavia diffusa root extract was carried out in CRF in dogs in comparison with standard enalapril. MATERIALS AND METHODS: A total of 20 dogs of mixed breeds suffering from CRF from 1 to 2 months were divided into two groups (n = 10) and treated as follows: Group I - Enalapril at 0...
July 2015: Journal of Ayurveda and Integrative Medicine
Hsin-Yi Shyu, Chun-Jung Ko, Yu-Chen Luo, Hsin-Ying Lin, Shang-Ru Wu, Shao-Wei Lan, Tai-Shan Cheng, Shih-Hsiung Hu, Ming-Shyue Lee
Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous effects, including renal failure; however, the underlying mechanism is poorly understood. The process called epithelial phenotypic changes (EPCs) causes the loss of cell-cell adhesion and cell polarity in renal diseases, as well as the acquisition of migratory and invasive properties. Madin-Darby canine kidney cells, an in vitro cell model, were subjected to experimental manipulation to investigate whether ketamine could promote EPCs...
April 2016: Journal of Cellular Biochemistry
Tomoko Ichiki, Brenda K Huntley, S Jeson Sangaralingham, John C Burnett
OBJECTIVES: The aim of this study was to determine if the atrial natriuretic peptide (ANP) precursor proANP is biologically active compared with ANP and B-type natriuretic peptide (BNP). BACKGROUND: ProANP is produced in the atria and processed to ANP and activates the guanylyl cyclase receptor-A (GC-A) and its second messenger, cyclic guanosine monophosphate (cGMP). ProANP is found in the human circulation, but its bioavailability is undefined. METHODS: The in vivo actions of proANP compared with ANP, BNP, and placebo were investigated in normal canines (667 pmol/kg, n = 5/group)...
September 2015: JACC. Heart Failure
Xiaozhan Wang, Qingyan Zhao, Shengbo Yu, Xule Wang, Jinping Xiao, Zixuan Dai, He Huang, Yanhong Tang, Congxin Huang
OBJECTIVE: To explore the role of renal sympathetic denervation (RSD) on ventricular substrate remodeling in dogs with pacing-induced heart failure (HF). METHODS: A total of 19 dogs were randomized into 3 groups of sham-operated control (n = 7), right ventricular pacing induction of HF (n = 6) and RSD (n = 6). After 8-week pacing induction of HF. Hemodynamic variables were monitored at baseline and after HF. Masson's trichrome staining, enzyme-linked immunosorbent assay (ELISA) and Western blot were used to measure ventricular interstitial fibrosis, brain natriuretic peptide (BNP), angiotensin II (Ang II), aldosterone and transforming growth factor-beta (TGF-β)...
March 24, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Kevin J Esch, Robert G Schaut, Ian M Lamb, Gwendolyn Clay, Ádila L Morais Lima, Paulo R P do Nascimento, Elizabeth M Whitley, Selma M B Jeronimo, Fayyaz S Sutterwala, Joseph S Haynes, Christine A Petersen
Chronic kidney disease is a major contributor to human and companion animal morbidity and mortality. Renal complications are sequelae of canine and human visceral leishmaniasis (VL). Despite the high incidence of infection-mediated glomerulonephritis, little is known about pathogenesis of VL-associated renal disease. Leishmania infantum-infected dogs are a naturally occurring model of VL-associated glomerulonephritis. Membranoproliferative glomerulonephritis type I [24 of 25 (96%)], with interstitial lymphoplasmacytic nephritis [23 of 25 (92%)], and glomerular and interstitial fibrosis [12 of 25 (48%)] were predominant lesions...
August 2015: American Journal of Pathology
Jennifer M Herring, Maureen A McMichael, Raffaella Corsi, Virginie Wurlod
OBJECTIVE: To report a case series of canine naproxen overdoses successfully treated with intravenous lipid emulsion therapy (IVLE). SERIES SUMMARY: Three dogs were presented for acute ingestion of naproxen and were treated with IVLE. Baseline and post treatment serum naproxen concentrations were measured. The first exposure involved ingestion of 61 mg/kg of an over-the-counter naproxen formulation in a 7-month-old male intact Labrador Retriever. Pre-IVLE toxin concentration assessed by high performance liquid chromatography (HPLC) was 73 μg/mL with a one-hour post-IVLE concentration decreasing to 30 μg/mL...
September 2015: Journal of Veterinary Emergency and Critical Care
Wayne L Miller, Daniel D Borgeson, J Aaron Grantham, Andreas Luchner, Margaret M Redfield, John C Burnett
AIMS: Aldosterone activation is central to the sodium–fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the role of dietary sodium during the progression of experimental HF. METHODS AND RESULTS: Experimental HF was produced in a canine model by rapid right ventricular pacing which evolves from early mild HF to overt, severe HF...
February 2015: European Journal of Heart Failure
T P Crotty
Experiments on canine lateral saphenous vein segments have shown that noradrenaline causes potent, flow dependent effects, at a threshold concentration comparable to that of plasma noradrenaline, when it stimulates a segment by diffusion from its microcirculation (vasa vasorum). The effects it causes contrast with those neuronal noradrenaline causes in vivo and that, in the light of the principle that all information is transmitted in patterns that need contrast to be detected - star patterns need darkness, sound patterns, quietness - has generated the hypothesis that plasma noradrenaline provides the obligatory contrast tissues need to detect and respond to the regulatory information encrypted in the diffusion pattern of neuronal noradrenaline...
November 2015: Medical Hypotheses
R Rørtveit, M R Reiten, F Lingaas, S B Sveri, A Brech, A Espenes, J H Jansen
Collagen type III glomerulopathy, also known as collagenofibrotic glomerulopathy, is a rare renal disease of unknown pathogenesis. The disease occurs in humans and animals and is characterized by massive glomerular accumulations of collagen type III. In the present study, we describe a Drever dog litter affected by an early onset variant of this glomerular disease, where 4 of 9 puppies developed renal failure within 50 days of age. Necropsy specimens of kidney from the 4 affected cases were studied by light microscopy, electron microscopy, and immunohistochemistry, and characteristic lesions compatible with a diagnosis of collagen type III glomerulopathy were found...
November 2015: Veterinary Pathology
Matteo Vassallo, Olivier Moranne, Damien Ambrosetti, Pierre-Yves Jeandel, Christelle Pomares, Elisabeth Cassuto, Annick Boscagli, Guillaume Giraud, Nathalie Montagne, Chiara Dentone, Ilaria Demacina, Barbara Villaggio, Giovanni Secondo, Giuseppe Ferrea, Corinne Passeron, Laurence Saudes, Regis Kaphan, Pierre Marty, Eric Rosenthal
BACKGROUND: We describe histological, clinical findings and outcomes of renal involvement during Leishmania infantum infection in four HIV-infected patients in South France and North Italy hospital settings. CASES PRESENTATION: Four HIV-infected Caucasian patients (age 24-49) performed renal biopsy during episodes of visceral leishmaniasis. They presented severe immunosuppression, frequent relapses of visceral leishmaniasis during a follow-up period of several years and partial or complete recovery of renal function after anti-parasitic treatment...
2014: BMC Infectious Diseases
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