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https://www.readbyqxmd.com/read/27929393/xylobiose-an-alternative-sweetener-ameliorates-diabetes-related-metabolic-changes-by-regulating-hepatic-lipogenesis-and-mir-122a-33a-in-db-db-mice
#1
Eunjin Lim, Ji Ye Lim, Eunju Kim, Yoo-Sun Kim, Jae-Ho Shin, Pu Reum Seok, Sangwon Jung, Sang-Ho Yoo, Yuri Kim
Type 2 diabetes is a major public health concern worldwide. Xylobiose (XB) consists of two molecules of d-xylose and is a major disaccharide in xylooligosaccharides that are used as prebiotics. We hypothesized that XB could regulate diabetes-related metabolic and genetic changes via microRNA expression in db/db mice. For six weeks, C57BL/KsJ-db/db mice received 5% XB as part of the total sucrose content of their diet. XB supplementation improved glucose tolerance with reduced levels of OGTT AUC, fasting blood glucose, HbA1c, insulin, and HOMA-IR...
December 5, 2016: Nutrients
https://www.readbyqxmd.com/read/27924908/development-of-novel-noninvasive-prenatal-testing-protocol-for-whole-autosomal-recessive-disease-using-picodroplet-digital-pcr
#2
Mun Young Chang, Ah Reum Kim, Min Young Kim, Soyoung Kim, Jinsun Yoon, Jae Joon Han, Soyeon Ahn, Changsoo Kang, Byung Yoon Choi
We developed a protocol of noninvasive prenatal testing (NIPT), employing a higher-resolution picodroplet digital PCR, to detect genetic imbalance in maternal plasma DNA (mpDNA) caused by cell-free fetal DNA (cffDNA). In the present study, this approach was applied to four families with autosomal recessive (AR) congenital sensorineural hearing loss. First, a fraction of the fetal DNA in mpDNA was calculated. Then, we made artificial DNA mixtures (positive and negative controls) to simulate mpDNA containing the fraction of cffDNA with or without mutations...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924196/nasogastric-tube-insertion-using-airway-tube-exchanger-in-anesthetized-and-intubated-patients
#3
Hyae-Jin Kim, Hyeon Jeong Lee, Hyun-Jun Cho, Hae-Kyu Kim, Ah-Reum Cho, Narae Oh
BACKGROUND: A nasogastric tube (NGT) is commonly inserted into patients undergoing abdominal surgery to decompress the stomach during or after surgery. However, for anatomic reasons, the insertion of NGTs into anesthetized and intubated patients may be challenging. We hypothesized that the use of a tube exchanger for NGT insertion could increase the success rate and reduce complications. METHODS: One hundred adult patients, aged 20-70 years, who were scheduled for gastrointestinal surgeries with general anesthesia and NGT insertion were enrolled in our study...
December 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27913885/effect-of-sensor-location-on-regional-cerebral-oxygen-saturation-measured-by-invos-5100-in-on-pump-cardiac-surgery
#4
Ah-Reum Cho, Jae-Young Kwon, Choongrak Kim, Jung-Min Hong, Christine Kang
PURPOSE: Near-infrared spectroscopy sensors often cannot be attached at the commercially recommended locations because combined use of neurological monitoring systems is common during on-pump cardiac surgery. The primary purpose of this study was to compare the incidence of regional cerebral oxygen desaturation and regional cerebral oxygen saturation values detected using near-infrared spectroscopy between the upper and lower forehead during on-pump cardiac surgery. METHODS: A prospective observational study was conducted with 25 adult patients scheduled for elective on-pump cardiac surgery...
December 2, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27899071/having-a-usual-source-of-care-and-its-associated-factors-in-korean-adults-a-cross-sectional-study-of-the-2012-korea-health-panel-survey
#5
Ah Reum An, Kyoungwoo Kim, Jae-Ho Lee, Nak-Jin Sung, Sang-Il Lee, Min Kyung Hyun
BACKGROUND: Usual source of care (USC) is one of the hallmarks of primary care. We aimed to examine the status of having a USC and its patient-related sociodemographic factors among Korean adults. METHODS: Data were obtained from the 2012 Korea Health Panel survey. Panel participants were selected for the study who were aged 18 years or older and who replied to questionnaire items on having a USC (n = 11,935). RESULTS: Of the participants, 21...
November 29, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27886419/functional-characterization-of-a-novel-loss-of-function-mutation-of-prps1-related-to-early-onset-progressive-nonsyndromic-hearing-loss-in-koreans-dfnx1-potential-implications-on-future-therapeutic-intervention
#6
So Young Kim, Ah Reum Kim, Nayoung K D Kim, Chung Lee, Jin Hee Han, Min Young Kim, Eun-Hee Jeon, Woong-Yang Park, Rahul Mittal, Denise Yan, Xue Zhong Liu, Byung Yoon Choi
BACKGROUND: The symptoms of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) deficiency diseases have been reported to be alleviated by medication. Herein, we report biochemical data to favor PRPS1 deficiency-related hearing loss as a potential target for pharmaceutical treatment. METHODS: We recruited 42 probands from subjects under the age of 15 years with a moderate degree of nonsyndromic autosomal-recessive or sporadic sensorineural hearing loss (SNHL) in at least one side...
November 25, 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27857027/determination-and-prediction-of-digestible-and-metabolizable-energy-concentrations-in-byproduct-feed-ingredients-fed-to-growing-pigs
#7
Ah Reum Son, Chan Sol Park, Beob Gyun Kim
Objective: An experiment was conducted to determine digestible energy (DE) and metabolizable energy (ME) of different byproduct feed ingredients fed to growing pigs, and to generate prediction equations for the DE and ME in feed ingredients. Methods: Twelve barrows with an initial mean body weight of 31.8 kg were individually housed in metabolism crates that were equipped with a feeder and a nipple drinker. A 12 × 10 incomplete Latin square design was employed with 12 dietary treatments, 10 periods, and 12 animals...
November 17, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27853382/genetic-variation-rs7930-in-the-mir-4273-5p-target-site-is-associated-with-a-risk-of-colorectal-cancer
#8
Ah-Reum Lee, Jongkeun Park, Keum Ji Jung, Sun Ha Jee, Sungjoo Kim-Yoon
PURPOSE: MicroRNAs (miRNAs) are noncoding RNAs that play roles as tumor suppressors or oncogenes by regulating the expression of target genes via binding to seed-match sequences. Polymorphisms in the miRNA-binding site of a target gene can alter miRNA binding and potentially affect the risk of cancer. The objective of this study was to identify single-nucleotide polymorphisms (SNPs) in miRNA-binding sites and assess their involvement in the risk of colorectal cancer (CRC). MATERIALS AND METHODS: SNPs in the 3' untranslated regions of genes were selected and assessed for their effects on CRC risk in Korean population using participants in Korean Cancer Prevention Study-II...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27833853/mouse-specific-up-regulation-of-ccnb1-expression-by-mir-199a-5p-in-keratinocyte
#9
Bong-Kyu Kim, Injung Kim, Ah-Reum Lee, Hye-In Yoo, Sungjoo Kim Yoon
MicroRNA (miRNA) are a class of single-stranded, small non-coding RNA that regulate various biological processes, including skin and hair cycle regulation, by modulating the expression of specific genes at the post-transcriptional level. Recently, several studies reported that miRNA directly or indirectly up-regulate target genes. Previously, we performed microarray analysis to identify the target genes of miR-199a-5p in a mouse skin keratinocyte cell line and detected more than 200 genes whose expression was significantly increased by miR-199a-5p overexpression (> 1...
November 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27800302/the-therapeutic-effect-of-plag-against-oral-mucositis-in-hamster-and-mouse-model
#10
Ha-Reum Lee, Nina Yoo, Joo Heon Kim, Ki-Young Sohn, Heung-Jae Kim, Myung-Hwan Kim, Mi Young Han, Sun Young Yoon, Jae Wha Kim
Chemotherapy-induced mucositis can limit the effectiveness of cancer therapy and increase the risk of infections. However, no specific therapy for protection against mucositis is currently available. In this study, we investigated the therapeutic effect of PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride) in 5-fluorouracil (5-FU)-induced oral mucositis animal models. Hamsters were administered 5-FU (80 mg/kg) intraperitoneally on days 0, 6, and 9. The animals' cheek pouches were then scratched equally with the tip of an 18-gage needle on days 1, 2, and 7...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27792758/discovery-of-cdh23-as-a-significant-contributor-to-progressive-postlingual-sensorineural-hearing-loss-in-koreans
#11
Bong Jik Kim, Ah Reum Kim, Chung Lee, So Young Kim, Nayoung K D Kim, Mun Young Chang, Jihye Rhee, Mi-Hyun Park, Soo Kyung Koo, Min Young Kim, Jin Hee Han, Seung-Ha Oh, Woong-Yang Park, Byung Yoon Choi
CDH23 mutations have mostly been associated with prelingual severe-to-profound sensorineural hearing loss (SNHL) in either syndromic or nonsyndromic SNHL (DFNB12). Herein, we demonstrate the contribution of CDH23 mutations to postlingual nonsyndromic SNHL (NS-SNHL). We screened 32 Korean adult probands with postlingual NS-SNHL sporadically or in autosomal recessive fashion using targeted panel or whole exome sequencing. We identified four (12.5%, 4/32) potential postlingual DFNB12 families that segregated the recessive CDH23 variants, qualifying for our criteria along with rapidly progressive SNHL...
2016: PloS One
https://www.readbyqxmd.com/read/27769678/serine-rich-repeat-adhesin-gordonii-surface-protein-b-is-important-for-streptococcus-gordonii-biofilm-formation
#12
A Reum Kim, Ki Bum Ahn, Hyun Young Kim, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
INTRODUCTION: Streptococcus gordonii is a predominant member of the oral microflora and has been isolated from root canals of teeth with refractory apical periodontitis. Biofilm formation is important for various dental diseases, and S. gordonii is involved in dental biofilm formation as an early colonizer. Although serine-rich repeat (SRR) adhesins of S. gordonii such as gordonii surface protein B (GspB) are associated with bacterial colonization, the role of GspB in biofilm formation is not clearly understood...
October 18, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27768721/regulation-of-srpr-expression-by-mir-330-5p-controls-proliferation-of-mouse-epidermal-keratinocyte
#13
Bong-Kyu Kim, Hye-In Yoo, Keonwoo Choi, Ah-Reum Lee, Sungjoo Kim Yoon
Srpr is a gene encoding α subunit of the signal recognition particle receptor which is involved in the targeting and translocation of nascent secretory and membrane proteins to the endoplasmic reticulum. Previous studies showed aberrant expression of Srpr in several cell types with abnormal growth rate. Although Srpr is expressed in various tissues including skin, the role of Srpr in keratinocytes and regulation of its expression by miRNAs have not been studied. In this study, we investigated the role of SRPR and regulation of its expression by miRNA in skin keratinocytes...
2016: PloS One
https://www.readbyqxmd.com/read/27757125/effects-of-psychiatric-symptoms-on-attention-in-north-korean-refugees
#14
Yu Jin Lee, Jin Yong Jun, Juhyun Park, Soohyun Kim, Ah Reum Gwak, So Hee Lee, So Young Yoo, Seog Ju Kim
OBJECTIVE: We investigated the performance of North Korean refugees on attention tasks, and the relationship between that performance and psychiatric symptoms. METHODS: Sustained and divided attention was assessed using the computerized Comprehensive Attention Test in North Korean refugees and in South Koreans. All participants also completed the Beck Depression Inventory, the Beck Anxiety Inventory, the Impact of Event Scale-Revised and the Dissociative Experiences Scale-II (DES-II)...
September 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27711255/scaffold-role-of-dusp22-in-ask1-mkk7-jnk-signaling-pathway
#15
Anna Ju, Young-Chang Cho, Ba Reum Kim, Sung Goo Park, Jeong-Hoon Kim, Kwonseop Kim, Jaehwi Lee, Byoung Chul Park, Sayeon Cho
Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed cell death. MAPKs are activated by dual phosphorylation on threonine and tyrosine residues through sequential activation of protein kinases. Recent studies have shown that the protein kinases involved in MAPK signal transductions might be organized into signaling complexes by scaffold proteins. These scaffold proteins are essential regulators that function by assembling the relevant molecular components in mammalian cells...
2016: PloS One
https://www.readbyqxmd.com/read/27703627/pretreatmet-with-5-lidocaine-patch-reduces-cannula-induced-and-propofol-induced-pain-a-randomized-double-blind-placebo-controlled-study
#16
Jung-Min Hong, Hyeon Jeong Lee, Ah Reum Cho, Ji Seok Baik, Do Won Lee, Young Tae Ji, Ki Chan Yoo, Hae-Kyu Kim
BACKGROUND: The purpose of this study was to determine the efficacy of 5% lidocaine patch in reducing propofol-induced pain and cannula-induced pain. METHODS: In a randomized, double-blind study, 126 patients were divided into one of three groups: pretreatment with a 5% lidocaine patch (Lidotop®) and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group A); pretreatment with a placebo patch and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group B); or pretreatment with a placebo patch and premixed 2 ml of 2% lidocaine (40 mg) with 1...
October 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27666485/thunbergia-alata-inhibits-inflammatory-responses-through-the-inactivation-of-erk-and-stat3-in-macrophages
#17
Young-Chang Cho, Ye Rang Kim, Ba Reum Kim, Tran The Bach, Sayeon Cho
Thunbergia alata (Acanthaceae) has been used traditionally to treat various inflammatory diseases such as fever, cough and diarrhea in East African countries including Uganda and Kenya. However, systemic studies elucidating the anti-inflammatory effects and precise mechanisms of action of T. alata have not been conducted, to the best of our knowledge. To address these concerns, we explored the anti-inflammatory effects of a methanol extract of T. alata (MTA) in macrophages. Non-cytotoxic concentrations of MTA (≤300 µg/ml) inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)‑stimulated RAW 264...
September 21, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27600064/biosynthesis-of-poly-2-hydroxyisovalerate-co-lactate-by-metabolically-engineered-escherichia-coli
#18
Jung Eun Yang, Je Woong Kim, Young Hoon Oh, So Young Choi, Hyuk Lee, A-Reum Park, Jihoon Shin, Si Jae Park, Sang Yup Lee
Polyhydroxyalkanoates (PHAs) containing 2-hydroxyacids such as lactate (LA) and 2-hydroxybutyrate (2HB) have recently been produced by metabolically engineered microorganisms. Here, we further expanded 2-hydroxyacid monomer spectrum of PHAs by engineering Escherichia coli to produce PHAs containing 2-hydroxyisovalerate (2HIV). To generate 2HIV in vivo, a feedback resistant ilvBN(mut) genes encoding acetohydroxyacid synthase and ilvCD genes encoding ketol-acid reductoisomerase and dihydroxyacid dehydratase, respectively, and panE gene encoding (D)-2-hydroxyacid dehydrogenase were overexpressed...
September 7, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27597151/adsorptive-separation-of-xenon-krypton-mixtures-using-a-zirconium-based-metal-organic-framework-with-high-hydrothermal-and-radioactive-stabilities
#19
Seung-Joon Lee, Tae-Ung Yoon, Ah-Reum Kim, Seo-Yul Kim, Kyung-Ho Cho, Young Kyu Hwang, Jei-Won Yeon, Youn-Sang Bae
The separation of xenon/krypton mixtures is important for both environmental and industrial purposes. The potential of three hydrothermally stable MOFs (MIL-100(Fe), MIL-101(Cr), and UiO-66(Zr)) for use in Xe/Kr separation has been experimentally investigated. From the observed single-component Xe and Kr isotherms, isosteric heat of adsorption (Qst(o)), and IAST-predicted Xe/Kr selectivities, we observed that UiO-66(Zr) has the most potential as an adsorbent among the three candidate MOFs. We performed dynamic breakthrough experiments with an adsorption bed filled with UiO-66(Zr) to evaluate further the potential of UiO-66(Zr) for Xe/Kr separation under mixture flow conditions...
December 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27596595/the-structure-of-the-pleiotropic-transcription-regulator-cody-provides-insight-into-its-gtp-sensing-mechanism
#20
Ah-Reum Han, Hye-Ri Kang, Jonghyeon Son, Do Hoon Kwon, Sulhee Kim, Woo Cheol Lee, Hyun Kyu Song, Moon Jung Song, Kwang Yeon Hwang
GTP and branched-chain amino acids (BCAAs) are metabolic sensors that are indispensable for the determination of the metabolic status of cells. However, their molecular sensing mechanism remains unclear. CodY is a unique global transcription regulator that recognizes GTP and BCAAs as specific signals and affects expression of more than 100 genes associated with metabolism. Herein, we report the first crystal structures of the full-length CodY complex with sensing molecules and describe their functional states...
September 4, 2016: Nucleic Acids Research
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