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https://www.readbyqxmd.com/read/28418336/intracranial-lesions-in-children-and-adolescents-with-morbid-obesity
#1
Ayça Törel Ergür, Sevinç Odabaşı Güneş, Sinan Tan, Ü Ayşe Tandırcıoğlu
BACKGROUND: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. AIMS: To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28404953/hydrogen-rich-saline-attenuates-spinal-cord-hemisection-induced-testicular-injury-in-rats
#2
Li Ge, Li-Hua Wei, Chang-Qing Du, Guo-Hua Song, Ya-Zhuo Xue, Hao-Shen Shi, Ming Yang, Xin-Xin Yin, Run-Ting Li, Xue-Er Wang, Zhen Wang, Wen-Gang Song
To study how hydrogen-rich saline (HS) promotes the recovery of testicular biological function in a hemi-sectioned spinal cord injury (hSCI) rat model, a right hemisection was performed at the T11-T12 of the spinal cord in Wistar rats. Animals were divided into four groups: normal group; vehicle group: sham-operated rats administered saline; hSCI group: subjected to hSCI and administered saline; HRST group: subjected to hSCI and administered HS. Hind limb neurological function, testis index, testicular morphology, mean seminiferous tubular diameter (MSTD) and seminiferous epithelial thickness (MSET), the expression of heme oxygenase-1 (HO-1), mitofusin-2 (MFN-2), and high-mobility group box 1 (HMGB-1), cell ultrastructure, and apoptosis of spermatogenic cells were studied...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28339047/hypothalamo%C3%A2-hypophysial-system-in-rats-with-autotransplantation-of-the-adrenal-cortex
#3
Nae Takizawa, Susumu Tanaka, Souichi Oe, Taro Koike, Tadashi Matsuda, Hisao Yamada
Patients with bilateral pheochromocytoma often require an adrenalectomy. Autotransplantation of the adrenal cortex is an alternative therapy that could potentially be performed instead of receiving glucocorticoid replacement following adrenalectomy. Adrenal cortex autotransplantation aims to avoid the side effects of long‑term steroid treatment and adrenal insufficiency. Although the function of the hypothalamo‑hypophysial system is critical for patients who have undergone adrenal cortex autotransplantation, the details of that system, with the exception of adrenocorticotropic hormone in the subjects with adrenal autotransplantation, have been overlooked for a long time...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28262495/-18-f-fdg-pet-ct-in-follow-up-evaluation-in-pediatric-patients-with-langerhans-histiocytosis
#4
J R Garcia, E Riera, P Bassa, S Mourelo, M Soler
PURPOSE: We evaluated the impact of (18)F-FDG PET/CT in identifying sites of active disease and to assess therapeutic follow up in a group of pediatric patients with Langerhans cell histiocytosis (LCH). METHOD: During 2007-2013, 13 (18)F-FDG PET/CT studies were performed for follow-up in 7 patients with a diagnosis of LCH (4 female, 3 male; 1-12 years-old). PET findings were analyzed and correlated with the CT and MRI. Findings were also follow-up by these techniques...
March 2, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28251898/pituitary-stalk-interruption-syndrome-a-rare-and-severe-cause-of-pituitary-deficiency-laboratory-diagnosis-of-a-newborn-case
#5
Thomas Boueilh, Corentin Bassi, Stéphanie Rouleau, Sébastien Le Crugel, Valérie Moal, Florence Boux de Casson, Régis Coutant, Delphine Mirebeau-Prunier, Pascal Reynier, Chadi Homedan
We report the case of a newborn with neonatal hypotonia associated to a micropenis and a bilateral cryptorchidia. The discovery of severe hypoglycemia at 0.22 mmol/L led to further biological investigations that revealed sharply decreased levels of several hypophyseal hormones. Altered corticotropic, somatotropic, thyreotropic, and gonadotropic axes finally suggested congenital hypophyseal insufficiency. This diagnostic was confirmed by a brain MRI (magnectic resonance imaging), which revealed a total interruption of the pituitary stalk...
March 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28235500/action-of-%C3%AE-endorphin-and-nonsteroidal-anti-inflammatory-drugs-and-the-possible-effects-of-nonsteroidal-anti-inflammatory-drugs-on-%C3%AE-endorphin
#6
REVIEW
Yuan-Hang Luan, Di Wang, Qi Yu, Xiao-Qing Chai
This study aimed to review research on the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on β-endorphin. NSAIDs are commonly used as anti-inflammatory and analgesic drugs. They are well known for inducing peripheral analgesia by inhibiting cyclooxygenase (COX). However, an increasing number of studies have shown that NSAIDs have an analgesic effect not only in the periphery but also at the center. It means that a central analgesic mechanism of the action of NSAIDs exists besides the peripheral mechanism, and the central mechanism likely involves β-endorphin...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28181232/does-iih-alter-brain-microstructures-a-dti-based-approach
#7
Christoph Schmidt, Edzard Wiener, Lutz Lüdemann, Hagen Kunte, Katharina Maria Kreutz, Nils Becker, Lutz Harms, Randolf Klingebiel, Jan Hoffmann
INTRODUCTION: To investigate the correlation of microstructural parameters with CSF pressure and macroscopic changes assessed by diffusion tensor imaging (DTI) in patients with idiopathic intracranial hypertension (IIH). METHODS: Twenty-three patients with IIH as well as age-, sex-, and body mass index (BMI)-matched controls underwent high resolution MR imaging of the optic nerve sheaths (ONS), pituitary gland, and ventricles. For DTI data a voxelwise permutation analysis was performed for the whole brain and ROI analysis was performed for the optic nerve and optic radiation...
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28149063/acute-effects-of-mobile-phone-radiations-on-subtle-energy-levels-of-teenagers-using-electrophotonic-imaging-technique-a-randomized-controlled-study
#8
Hemant Bhargav, T M Srinivasan, Suman Bista, A Mooventhan, Vandana Suresh, Alex Hankey, H R Nagendra
BACKGROUND: Mobile phones induce radio frequency electromagnetic field (RF-EMF) which has been found to affect subtle energy levels of adults through Electrophotonic Imaging (EPI) technique in a previous pilot study. MATERIALS AND METHODS: We enrolled 61 healthy right-handed healthy teenagers (22 males and 39 females) in the age range of 17.40 ± 0.24 years from educational institutes in Bengaluru. Subjects were randomly divided into two groups: (1) (mobile phone in ON mode [MPON] at right ear) and (2) mobile phone in OFF mode (MPOF)...
January 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/28086988/computed-tomographic-findings-and-treatment-of-a-bull-with-pituitary-gland-abscess
#9
Ueli Braun, Alexandra Malbon, Manon Kochan, Barbara Riond, Fredi Janett, Cornelia Iten, Matthias Dennler
BACKGROUND: In cattle, the prognosis of brain abscess is unfavourable and treatment is therefore not recommended. To the knowledge of the authors, there has been no report of successful treatment of a brain abscess in cattle.This report describes the clinical, computed tomographic and postmortem findings in a Holstein-Friesian bull with a hypophyseal abscess. CASE REPORT: The main clinical findings were generalised ataxia, ptyalism, prolapse of the tongue, dropped jaw, dysphagia, head tilt and unilateral ptosis...
January 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27999963/identification-of-an-endocannabinoid-system-in-the-rat-pars-tuberalis-a-possible-interface-in-the-hypothalamic-pituitary-adrenal-system
#10
Arsalan Jafarpour, Faramarz Dehghani, Horst-Werner Korf
Endocannabinoids (ECs) are ubiquitous endogenous lipid derivatives and play an important role in intercellular communication either in an autocrine/paracrine or in an endocrine fashion. Recently, an intrinsic EC system has been discovered in the hypophysial pars tuberalis (PT) of hamsters and humans. In hamsters, this EC system is under photoperiodic control and appears to influence the secretion of hormones such as prolactin from the adenohypophysis. We investigate the EC system in the PT of the rat, a frequently used species in endocrine research...
December 20, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27843750/permeability-and-distribution-of-nerve-growth-factor-in-the-brain-of-neonatal-rats-by-periphery-venous-injection-in-hypoxic-ischemic-state
#11
Wenli Zhou, Jiantao Zhang, Guangming Wang, Limian Ling, Chaoying Yan
OBJECTIVE: To investigate the permeability of β-NGF through blood-brain-barrier (BBB) in neonatal and adult rats, and the spatial distribution of β-NGF in different brain regions in hypoxic-ischemic (HI) and normal neonatal rats. METHODS: To investigate the overall permeability of β-NGF through BBB, β-NGF labeled with I(125) was injected into adult rats, neonatal rats and HI neonatal rats via tail vein. The radioactivity of brain tissue and blood was examined and analyzed 30 min after injection...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27822880/tracing-of-zinc-nanocrystals-in-the-anterior-pituitary-of-zinc-deficient-wistar-rats
#12
Anjana Kuldeep, Neena Nair, Ranveer Singh Bedwal
The aim of this study was to trace zinc nanocrystals in the anterior pituitary of zinc-deficient Wistar rats by using autometallographic technique. Male Wistar rats (30-40 days of age, pre-pubertal period) of 40-50 g body weight were divided into the following: the ZC (zinc control) group-fed with 100 ppm zinc in diet, the ZD (zinc-deficient) group-fed with zinc-deficient (1.00 ppm) diet and the PF (pair-fed) group-received 100 ppm zinc in diet. The experiments were set for 2 and 4 weeks. Pituitary was removed and processed for the autometallographic technique...
November 7, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27713869/short-period-influence-of-chronic-morphine-exposure-on-serum-levels-of-sexual-hormones-and-spermatogenesis-in-rats
#13
Hasan Ahmadnia, Alireza Akhavan Rezayat, Mahmood Hoseyni, Nooriye Sharifi, Mohhamad Khajedalooee, Arash Akhavan Rezayat
BACKGROUND: Increased rates of addiction and its broad societal complications are well known. One of the most important systems that may malfunction in drug abusers is the reproductive system, and evaluating patients for this potential risk may lead to increased awareness. MATERIALS AND METHODS: Thirty 60-day-old male rats were divided into control and target groups. The target group underwent 5 mg/kg intraperitoneal injections of morphine twice a day while the control group underwent normal saline injections (at the same dosage)...
July 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27651755/trpv1-may-increase-the-effectiveness-of-estrogen-therapy-on-neuroprotection-and-neuroregeneration
#14
REVIEW
Ricardo Ramírez-Barrantes, Ivanny Marchant, Pablo Olivero
Aging induces physical deterioration, loss of the blood brain barrier, neuronal loss-induced mental and neurodegenerative diseases. Hypotalamus-hypophysis-gonad axis aging precedes symptoms of menopause or andropause and is a major determinant of sensory and cognitive integrated function. Sexual steroids support important functions, exert pleiotropic effects in different sensory cells, promote regeneration, plasticity and health of the nervous system. Their diminution is associated with impaired cognitive and mental health and increased risk of neurodegenerative diseases...
August 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27611335/stress-increases-gonadotropin-inhibitory-hormone-cell-activity-and-input-to-gonadotropin-releasing-hormone-cells-in-ewes
#15
Iain J Clarke, Danielle Bartolini, Gregory Conductier, Belinda A Henry
Stress reduces GnRH and gonadotropin secretion in sheep, but the central mechanism for this suppressive effect is unknown. GnIH negatively regulates GnRH neurons and gonadotropes. Here, we measured activity of GnIH neurons and contact of GnIH fibres on GnRH neurons during either chronic 'pseudo-stress' or acute stress in sheep. We also measured GnIH secretion into hypophysial portal blood during 'pseudo-stress' and acute stress. The 'pseudo-stress' was daily i.m. injections (0.5mg) of Synacthen Depot (adrenocorticotropin) or vehicle for 4 weeks, which increased the GnIH cell number and gene expression/cell in the hypothalamus, measured by in situ hybridisation...
September 9, 2016: Endocrinology
https://www.readbyqxmd.com/read/27610925/nata-is-required-for-suspensor-development-in-arabidopsis
#16
Jinlin Feng, Ligeng Ma
Suspensor development is essential for early embryogenesis. The filamentous suspensor plays vital roles in supporting the embryo proper and in exchanging nutrients and information between the embryo proper and embryo sac. In addition, at the globular stage, the uppermost suspensor cell differentiates into the hypophysis, which generates the progenitors of the quiescent center and columella stem cells. In naa10 and naa15 mutant plants, suspensor cell identity was found to be abnormal and embryo development was disturbed, leading to embryonic lethality...
October 2, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27583870/sudden-unexpected-death-of-a-15-year-old-boy-due-to-pancarditis-a-case-report-and-possible-etiopathogenesis
#17
Antonio Osculati, Silvia Damiana Visonà, Francesco Ventura, Francesca Castelli, Luisa Andrello
BACKGROUND: Generally, rheumatic heart disease is, today, sporadic in developed countries, even though it continues to be a major health hazard in the developing ones. It is also a very rare cause of sudden unexpected death. We report a case of a 15-year-old boy who suddenly died at home. Since 3 days he had presented fever and chest pain. The family physician had diagnosed bronchitis and treated the boy with amoxicillin. METHODS: Seven hours after death, a forensic autopsy were performed ...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27464540/-correlations-between-hormone-levels-and-psychiatric-symptoms-as-well-as-cognitive-function-in-drug-free-first-episode-schizophrenics
#18
X X Yuan, Q Y Zhu, H B Liang, G R Hei, X Li, L J Pang, H H Li, H Li, X Q Song
OBJECTIVE: To explore hormone such as follicle-stimulating hormone (FSH), luteinizing (LH), prolactin (PRL), estradiol (E2), progesterone (PROG) and testosterone (TESTO) levels in first-episode drug-free schizophrenics, and the relationship between clinical symptoms and sex hormones, in order to further study the pathogenesis of schizophrenia. METHODS: Eighty-one first-episode drug-free schizophrenics including thirty-nine male and forty-two female from First Affiliated Hospital of Zhengzhou University and seventy healthy subjects (thirty male and forty female) were enrolled...
July 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27396833/neuroanatomical-evidence-for-the-involvement-of-%C3%AE-endorphin-during-reproductive-stress-response-in-the-fish-oreochromis-mossambicus
#19
Ambarisha Chabbi, C B Ganesh
Although neuroendocrine regulation of stress response involving hypothalamo-pituitary-adrenal axis is well established in mammals, the mechanism of functioning of endocrine-stress axis is not completely elucidated in fish. Our previous studies suggested a possible role for the opioidergic mediation of reproductive stress response in fish. In the present investigation, by immunocytochemical approach, we studied the distribution of β-endorphin (β-EP) secreting neurons in the brain of the tilapia Oreochromis mossambicus exposed to aquacultural stressors...
July 7, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27385766/protein-n-terminal-acetylation-is-required-for-embryogenesis-in-arabidopsis
#20
Jinlin Feng, Ruiqi Li, Junya Yu, Shuangshuang Ma, Chunyan Wu, Yan Li, Ying Cao, Ligeng Ma
Early embryonic development generates precursors of all major cell types in Arabidopsis. Among these precursors, the hypophysis divides asymmetrically to form the progenitors of the quiescent center and columella stem cells. A great deal has been learnt about the mechanisms that control the asymmetric division of the hypophysis and embryogenesis at the transcriptional level; however, no evidence of regulation at the co- or post-translational level has been reported. Here, we show that mutation of the catalytic subunit (Naa10) or auxiliary subunit (Naa15) of NatA, an N-terminal acetyltransferase that catalyzes protein N-terminal acetylation, produces an embryo-lethal phenotype...
August 2016: Journal of Experimental Botany
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