Peiqian Zhou, Tuozhou Liu, Wenbin Liu, Lingshun Sun, Haifei Kang, Kun Liu, Peiyuan Luo, Youfa Wang, Ling Luo, Honglian Dai
The periosteum, rich in neurovascular networks, bone progenitor cells, and stem cells, is vital for bone repair. Current artificial periosteal materials face challenges in mechanical strength, bacterial infection, and promoting osteogenic differentiation and angiogenesis. To address these issues, we adjusted the electrospinning ratio of poly-ε-caprolactone and chitosan and incorporated Zn doping whitlockite with polydopamine coating into a nanofiber membrane. After a series of characterizations, optimal results were achieved with a poly-ε-caprolactone: chitosan ratio of 8:1 and 5% nanoparticle content...
April 16, 2024: ACS Applied Materials & Interfaces