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https://www.readbyqxmd.com/read/28813505/allostatic-load-as-a-predictor-of-all-cause-and-cause-specific-mortality-in-the-general-population-evidence-from-the-scottish-health-survey
#1
Tony Robertson, Gayle Beveridge, Catherine Bromley
Allostatic load is a multiple biomarker measure of physiological 'wear and tear' that has shown some promise as marker of overall physiological health, but its power as a risk predictor for mortality and morbidity is less well known. This study has used data from the 2003 Scottish Health Survey (SHeS) (nationally representative sample of Scottish population) linked to mortality records to assess how well allostatic load predicts all-cause and cause-specific mortality. From the sample, data from 4,488 men and women were available with mortality status at 5 and 9...
2017: PloS One
https://www.readbyqxmd.com/read/28804509/lifetime-stress-exposure-and-health-a-review-of-contemporary-assessment-methods-and-biological-mechanisms
#2
Grant S Shields, George M Slavich
Life stress is a central construct in health research because it is associated with increased risk for a variety of serious mental and physical health problems, including anxiety disorders, depression, cardiovascular disease, autoimmune disorders, Alzheimer's disease, certain cancers, and other diseases of aging. In this review, we examine how lifetime stress exposure contributes to elevated disease risk, and explore ongoing measurement and scientific issues related to this topic. To accomplish these goals, we first review existing instruments that have been developed for assessing perceived stress, self-reported life events, interviewer-assessed life stressors, and lifetime stress exposure...
August 2017: Social and Personality Psychology Compass
https://www.readbyqxmd.com/read/28767672/bi-stability-in-type-2-diabetes-mellitus-multi-organ-signalling-network
#3
Shubhankar Kulkarni, Sakshi Sharda, Milind Watve
Type 2 diabetes mellitus (T2DM) is believed to be irreversible although no component of the pathophysiology is irreversible. We show here with a network model that the apparent irreversibility is contributed by the structure of the network of inter-organ signalling. A network model comprising all known inter-organ signals in T2DM showed bi-stability with one insulin sensitive and one insulin resistant attractor. The bi-stability was made robust by multiple positive feedback loops suggesting an evolved allostatic system rather than a homeostatic system...
2017: PloS One
https://www.readbyqxmd.com/read/28765100/pacing-conventional-physical-activity-and-active-video-games-to-increase-physical-activity-for-adults-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome-protocol-for-a-pilot-randomized-controlled-trial
#4
Katia Elizabeth Ferrar, Ashleigh E Smith, Kade Davison
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious illness of biological origin characterized by profound physical and cognitive exhaustion and postexertion malaise. Pacing is a common strategy used to manage available energy and complete activities of daily living; yet little research has investigated this as a strategy to increase physical activity levels. Typically, people living with ME/CFS are faced by unique barriers to physical activity participation and are less physically active than healthy peers...
August 1, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28761937/allostatic-breakdown-of-cascading-homeostat-systems-a-computational-approach
#5
Alison Acevedo, Ioannis P Androulakis
Homeostasis posits that physiological systems compensate setpoint deviations in an attempt to maintain a state of internal constancy. Allostasis, on the other hand, suggests that physiological regulation is more appropriately described by predictive modulatory actions that, by adjusting setpoints, anticipate and react to changes in internal and external demand. In other words, "maintaining stability through change." The allostatic perspective enabled the rationalization of predictive and reactive homeostasis...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28752903/erythropoietin-prevents-the-effect-of-chronic-restraint-stress-on-the-number-of-hippocampal-ca3c-dendritic-terminals-relation-to-expression-of-genes-involved-in-synaptic-plasticity-angiogenesis-inflammation-and-oxidative-stress-in-male-rats
#6
Nadia Aalling, Ida Hageman, Kamilla Miskowiak, Dariusz Orlowski, Gregers Wegener, Gitta Wortwein
Stress-induced allostatic load affects a variety of biological processes including synaptic plasticity, angiogenesis, oxidative stress, and inflammation in the brain, especially in the hippocampus. Erythropoietin (EPO) is a pleiotropic cytokine that has shown promising neuroprotective effects. Recombinant human EPO is currently highlighted as a new candidate treatment for cognitive impairment in neuropsychiatric disorders. Because EPO enhances synaptic plasticity, attenuates oxidative stress, and inhibits generation of proinflammatory cytokines, EPO may be able to modulate the effects of stress-induced allostatic load at the molecular level...
July 28, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28742501/novel-insights-into-the-molecular-mechanisms-underlying-generalized-glucocorticoid-resistance-and-hypersensitivity-syndromes
#7
REVIEW
Nicolas C Nicolaides, Evangelia Charmandari
Glucocorticoids play a fundamental role in many physiologic functions and contribute substantially to the achievement of homeostasis. These pleiotropic glucocorticoid actions are mediated by a ubiquitously expressed transcription factor, the human glucocorticoid receptor (hGR), which may influence the transcription rate of numerous target genes, interact with other transcription factors, trigger the activation of several kinase pathways or modulate mitochondrial DNA expression. Any genetic defects in the NR3C1gene that encodes the hGR may cause Primary Generalized Glucocorticoid Resistance or Hypersensitivity Syndromes, two rare allostatic endocrinologic conditions characterized by partial impaired tissue sensitivity to glucocorticoids...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28709033/vegetated-land-cover-near-residence-is-associated-with-reduced-allostatic-load-and-improved-biomarkers-of-neuroendocrine-metabolic-and-immune-functions
#8
Andrey I Egorov, Shannon M Griffin, Reagan R Converse, Jennifer N Styles, Elizabeth A Sams, Anthony Wilson, Laura E Jackson, Timothy J Wade
BACKGROUND: Greater exposure to urban green spaces has been linked to reduced risks of depression, cardiovascular disease, diabetes and premature death. Alleviation of chronic stress is a hypothesized pathway to improved health. Previous studies linked chronic stress with a biomarker-based composite measure of physiological dysregulation known as allostatic load. OBJECTIVE: This study's objective was to assess the relationship between vegetated land cover near residences and allostatic load...
July 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28693012/stress-measured-by-allostatic-load-in-neurologically-impaired-children-the-importance-of-nutritional-status
#9
Valeria Calcaterra, Hellas Cena, Annalisa de Silvestri, Riccardo Albertini, Mara De Amici, Mario Valenza, Gloria Pelizzo
BACKGROUND: Allostatic load (AL) is the cumulative physiological wear and tear that results from repeated efforts to adapt to stressors over time. The life stress response is modified by nutritional status. AIM: We estimated AL scores among neurologically impaired (NI) children; the association with malnutrition was also evaluated. METHODS: Forty-one patients with severe disabilities were included. Data based on 15 biomarkers were used to create the AL score...
July 10, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28659244/long-term-physical-health-consequences-of-perceived-inequality-results-from-a-twin-comparison-design
#10
Joseph A Schwartz
RATIONALE: Previous research has identified long-term exposure to stress as a risk factor for negative mental and physical health outcomes. This pattern of findings suggests that environmental stimuli that evoke feelings of stress or strain may also result in physiological responses, which may accumulate over the life course and ultimately increase the overall risk of various physical health conditions. This physiological "wear and tear" resulting from sustained levels of stress or strain has been previously operationalized as allostatic load (AL), a comprehensive indicator of stress exposure...
June 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28653044/neuroclinical-framework-for-the-role-of-stress-in-addiction
#11
Laura E Kwako, George F Koob
Addiction has been conceptualized as a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that worsens over time and involves allostatic changes in hedonic function via changes in the brain reward and stress systems. Using the withdrawal/negative affect stage and negative reinforcement as an important source of motivation for compulsive drug seeking, we outline the neurobiology of the stress component of the withdrawal/negative affect stage and relate it to a derivative of the Research Domain Criteria research construct for the study of psychiatric disease, known as the Addictions Neuroclinical Assessment...
February 2017: Chronic stress
https://www.readbyqxmd.com/read/28651371/sleep-and-physiological-dysregulation-a-closer-look-at-sleep-intraindividual-variability
#12
Bei Bei, Teresa E Seeman, Judith E Carroll, Joshua F Wiley
Study Objectives: Variable daily sleep (i.e., higher intraindividual variability; IIV) is associated with negative health consequences, but potential physiological mechanisms are poorly understood. This study examined the associations between sleep timing, duration, and quality IIV and physiological dysregulation, with diurnal cortisol trajectories as a proximal outcome, and allostatic load (AL) as a multi-system distal outcome. Methods: Participants are 436 adults (Mage±SD=54...
June 23, 2017: Sleep
https://www.readbyqxmd.com/read/28643579/religious-participation-and-biological-functioning-in-mexico
#13
Terrence D Hill, Sunshine M Rote, Christopher G Ellison
OBJECTIVE: Although several studies suggest that religious involvement tends to favor healthy biological functioning, most of this work has been conducted in the United States. This study explores the association between religious participation and biological functioning in Mexico. METHOD: The data are drawn from two waves of the Mexican Health and Aging Study (2003-2012) to assess continuous and categorical biomarker specifications. RESULTS: Across specifications, religious participation in 2003 is associated with lower levels of waist-to-hip ratio, total cholesterol, pulse rate, and overall allostatic load in 2012...
June 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28625102/spatiotemporal-meta-analysis-reviewing-health-psychology-phenomena-over-space-and-time
#14
Blair T Johnson, Ellen K Cromley, Natasza Marrouch
Individual studies of health psychology are samples taken in particular places at particular times. The results of such studies manifest multiple processes, including those associated with individual, sample, intervention, and study design characteristics. Although extant meta-analyses of health phenomena have routinely considered these factors to explain heterogeneity, they have tended to neglect the environments where studies are conducted, which is ironic, as health phenomena cluster in space and times (e...
September 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28576664/uncertainty-and-stress-why-it-causes-diseases-and-how-it-is-mastered-by-the-brain
#15
REVIEW
Achim Peters, Bruce S McEwen, Karl Friston
The term 'stress' - coined in 1936 - has many definitions, but until now has lacked a theoretical foundation. Here we present an information-theoretic approach - based on the 'free energy principle' - defining the essence of stress; namely, uncertainty. We address three questions: What is uncertainty? What does it do to us? What are our resources to master it? Mathematically speaking, uncertainty is entropy or 'expected surprise'. The 'free energy principle' rests upon the fact that self-organizing biological agents resist a tendency to disorder and must therefore minimize the entropy of their sensory states...
September 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28561181/-the-load-of-injustice-a-longitudinal-analysis-of-the-impact-of-subjectively-perceived-income-injustice-on-the-risk-of-stress-associated-diseases-based-on-the-german-socio-economic-panel-study
#16
Claudia Boscher, Laura Arnold, Andreas Lange, Bertram Szagun
Background Income injustice is regarded as a psychosocial strain and associated with an increased risk of stress-related diseases. The physiological stress response is thereby considered as a central link. The aim of the study is to reveal the influence of subjectively perceived income injustice on stress-associated diseases, taking into consideration the load duration. Method Based on the German Socio-Economic Panel Study, data on 5,657 workers in the survey years 2005-2013 were analyzed. The dependent variable reflect the doctor's diagnosed new cases of diabetes, asthma, cardiopathy, stroke, hypertension and depression in the years 2009-2013 as an index...
May 30, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28554610/reverse-allostasis-in-biological-systems-minimal-conditions-and-implications
#17
Nasrollah Rezaei-Ghaleh, Davood Bakhtiari, Armin Rashidi
Biological control systems regulate the behavior of biological systems in a constantly changing environment. Homeostasis is the most widely studied outcome of biological control systems. Homeostatic systems maintain the system in its desired state despite variations in system parameters or the externally-determined input rates of their constituents, i.e. they have zero or near zero steady state error. On the other hand, allostatic systems are not resistant against environmental changes and the steady state level of their controlled variables responds positively to the changes in their input rates...
May 26, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28535254/invited-commentary-cassel-s-the-contribution-of-the-social-environment-to-host-resistance-a-modern-classic
#18
Sherman A James
John Cassel's 1976 paper "The Contribution of the Social Environment to Host Resistance" (Am J Epidemiol. 1976;104(2):107-123) is widely regarded as a classic in epidemiology. He makes the compelling argument that the quality of a person's social relationships, that is, the degree to which her relationships are more stressful than supportive (or vice versa) influences her susceptibility to disease independent of genetic endowment, diet, physical activity, etc. Cassel's provocative thesis was anchored in a cogent synthesis of findings from animal experiments and observational studies on diverse human populations...
June 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28522128/does-adult-attachment-style-mediate-the-relationship-between-childhood-maltreatment-and-mental-and-physical-health-outcomes
#19
Cathy Spatz Widom, Sally J Czaja, Sandra Sepulveda Kozakowski, Preeti Chauhan
Attachment theory has been proposed as one explanation for the relationship between childhood maltreatment and problematic mental and physical health outcomes in adulthood. This study seeks to determine whether: (1) childhood physical abuse and neglect lead to different attachment styles in adulthood, (2) adult attachment styles predict subsequent mental and physical health outcomes, and (3) adult attachment styles mediate the relationship between childhood physical abuse and neglect and mental and physical health outcomes...
May 15, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28520779/church-attendance-allostatic-load-and-mortality-in-middle-aged-adults
#20
Marino A Bruce, David Martins, Kenrik Duru, Bettina M Beech, Mario Sims, Nina Harawa, Roberto Vargas, Dulcie Kermah, Susanne B Nicholas, Arleen Brown, Keith C Norris
IMPORTANCE: Religiosity has been associated with positive health outcomes. Hypothesized pathways for this association include religious practices, such as church attendance, that result in reduced stress. OBJECTIVE: The objective of this study was to examine the relationship between religiosity (church attendance), allostatic load (AL) (a physiologic measure of stress) and all-cause mortality in middle-aged adults. DESIGN, SETTING AND PARTICIPANTS: Data for this study are from NHANES III (1988-1994)...
2017: PloS One
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