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https://www.readbyqxmd.com/read/29457778/theoretical-investigation-of-performance-of-armchair-graphene-nanoribbon-field-effect-transistors
#1
Ji-Hyun Hur, Deok-Kee Kim
In this paper, we examine the highest possible performance level of graphene nanoribbon field effect transistors (GNRFETs) for wide range of operation voltages and device structure parameters such as width of graphene nanoribbon and gate length. To achieve this goal, we formulated a self-consistent non-equilibrium Green's function (NEGF) method in conjunction with the Poisson equation. We model the operation of nanometer sized GNRFETs of which GNR channels have finite bandgaps so that the GNRFET can operate as a switch...
February 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29457737/determining-the-value-of-cerebrospinal-fluid-lactate-dehydrogenase-level-in-differentiating-subarachnoid-hemorrhage-from-traumatic-lumbar-puncture
#2
Morteza Saeedi, Elnaz Vahidi, Shirin Asri, Amirhosein Jahanshir
CONTEXT: - Lumbar puncture (LP) is still an important modality in the diagnosis of subarachnoid hemorrhage (SAH). Rapid and correct fluid analysis can provide patients with a better prognosis by appropriate intervention. OBJECTIVE: - To determine the value of cerebrospinal fluid lactate dehydrogenase level in differentiation between SAH and traumatic LP. DESIGN: - This was a cross-sectional observational study. Patients with a diagnostic suspicion of SAH, who were admitted to the emergency department, were enrolled in our study based on the inclusion criteria...
February 19, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29454992/a-novel-%C3%AE-glucosidase-isolated-from-the-microbial-metagenome-of-lake-poraqu%C3%A3%C2%AA-amazon-brazil
#3
Danyelle Toyama, Mariana Abrahão Bueno de Morais, Felipe Cardoso Ramos, Letícia Maria Zanphorlin, Celisa Caldana Costa Tonoli, Augusto Furio Balula, Fernando Pellon de Miranda, Vitor Medeiros Almeida, Sandro Roberto Marana, Roberto Ruller, Mario Tyago Murakami, Flavio Henrique-Silva
The Amazon region holds most of the biological richness of Brazil. Despite their ecological and biotechnological importance, studies related to microorganisms from this region are limited. Metagenomics leads to exciting discoveries, mainly regarding non-cultivable microorganisms. Herein, we report the discovery of a novel β-glucosidase (glycoside hydrolase family 1) gene from a metagenome from Lake Poraquê in the Amazon region. The gene encodes a protein of 52.9 kDa, named AmBgl-LP, which was recombinantly expressed in Escherichia coli and biochemically and structurally characterized...
February 15, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29454352/lower-pole-approach-in-retroperitoneal-laparoscopic-radical-nephrectomy-a-new-approach-for-the-management-of-renal-vascular-pedicle
#4
Bo Yuan, Yuantao Wang, Jialin Gao, Yongrui Zhang, Yaowen Fu, Wei An
BACKGROUND: The objective of this study was to examine the effectiveness and safety of lower pole (LP) approach in retroperitoneal laparoscopic radical nephrectomy (LRN). METHODS: One hundred thirty-two renal cancer patients were scheduled for selective retroperitoneal LRN. The surgery parameters and outcomes were compared. Out of 132 patients, 78 (59.1%) patients underwent LRN via LP approach, while 54 (40.9%) patients underwent LRN via lateroposterior space (LPS) approach...
February 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29453971/prediction-value-of-serum-hbv-large-surface-protein-in-different-phases-of-hbv-infection-and-virological-response-of-chronic-hepatitis-b-patients
#5
Can Liu, Wennan Wu, Hongyan Shang, Sheng Lin, Zhen Xun, Er Huang, Jinpiao Lin, Bin Yang, Qishui Ou
BACKGROUND: Serum HBV large surface protein (HBV-LP) is an envelope protein that has a close relationship with HBV DNA level. This study is to explore the prediction value of HBV-LP in different phase of HBV infection and during antiviral therapy in chronic hepatitis B (CHB) patients. METHODS: A retrospective study was conducted in 2033 individuals, which included 1677 HBV infected patients in different phases and 356 healthy controls. HBV-LP, HBV serum markers and HBV DNA were detected by ELISA, CMIA and qRT-PCR, respectively...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453902/perioperative-outcome-and-complications-following-laparoscopic-versus-robotic-assisted-dismembered-pyeloplasty-a-systematic-review-and-meta-analysis
#6
REVIEW
Alexander Light, Sandeep Karthikeyan, Sachan Maruthan, Oussama ElHage, Hansjörg Danuser, Prokar Dasgupta
OBJECTIVE: To analyse the current difference between dismembered robotic-assisted pyeloplasty (RP) and laparoscopic pyeloplasty (LP) in the treatment of pelvi-ureteric junction obstruction (PUJO) patients as of June 26 2017, focusing on operative time, length of hospital stay, complication rate, and success rate. PATIENTS AND METHODS: We searched PubMed, Medline, and Embase databases, consulted experts, reviewed reference lists, used the related articles PubMed feature, and reviewed scientific meeting abstracts for eligible articles from 1993 to June 26 2017...
February 17, 2018: BJU International
https://www.readbyqxmd.com/read/29449329/impact-of-apolipoprotein-a-isoform-size-on-lipoprotein-a-lowering-in-the-hps2-thrive-study
#7
Sarah Parish, Jemma C Hopewell, Michael R Hill, Santica Marcovina, Elsa Valdes-Marquez, Richard Haynes, Alison Offer, Terje R Pedersen, Colin Baigent, Rory Collins, Martin Landray, Jane Armitage
BACKGROUND: Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on the benefits of therapies that lower Lp(a) remains unclear. METHODS: HPS2-THRIVE (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) is a randomized trial of niacin-laropiprant versus placebo on a background of simvastatin therapy...
February 2018: Circ Genom Precis Med
https://www.readbyqxmd.com/read/29449027/suberized-transport-barriers-in-arabidopsis-barley-and-rice-roots-from-the-model-plant-to-crop-species
#8
Tino Kreszies, Lukas Schreiber, Kosala Ranathunge
Water is the most important prerequisite for life and plays a major role during uptake and transport of nutrients. Roots are the plant organs that take up the major part of water, from the surrounding soil. Water uptake is related to the root system architecture, root growth, age and species dependent complex developmental changes in the anatomical structures. The latter is mainly attributed to the deposition of suberized barriers in certain layers of cell walls, such as endo- and exodermis. With respect to water permeability, changes in the suberization of roots are most relevant...
February 7, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29447785/association-of-lipoprotein-associated-phospholipase-a-2-and-risk-of-incident-atrial-fibrillation-findings-from-3-cohorts
#9
Parveen K Garg, Traci M Bartz, Faye L Norby, Neal W Jorgensen, Robyn L McClelland, Christie M Ballantyne, Lin Y Chen, John S Gottdiener, Philip Greenland, Ron Hoogeveen, Nancy S Jenny, Jorge R Kizer, Robert S Rosenson, Elsayed Z Soliman, Mary Cushman, Alvaro Alonso, Susan R Heckbert
BACKGROUND: Multiple prospective studies have established an association between inflammation and higher risk of atrial fibrillation (AF), but the association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) mass and activity and incident AF has not been extensively evaluated. METHODS: Using data from 10,794 Atherosclerosis Risk In Communities (ARIC) study participants aged 53-75 years, 5,181 Cardiovascular Health Study (CHS) participants aged 65 to 100 years, and 5,425 Multi-Ethnic Study of Atherosclerosis (MESA) participants aged 45-84 years, we investigated the association between baseline Lp-PLA 2 levels and the risk of developing AF...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29445136/goblet-cell-associated-antigen-passages-are-inhibited-during-salmonella-typhimur-cium-infection-to-prevent-pathogen-dissemination-and-limit-responses-to-dietary-antigens
#10
Devesha H Kulkarni, Keely G McDonald, Kathryn A Knoop, Jenny K Gustafsson, Konrad M Kozlowski, David A Hunstad, Mark J Miller, Rodney D Newberry
Dietary antigen acquisition by lamina propria (LP) dendritic cells (DCs) is crucial to induce oral tolerance and maintain homeostasis. However, encountering innocuous antigens during infection can lead to inflammatory responses, suggesting processes may limit steady-state luminal antigen capture during infection. We observed that goblet cell (GC) associated antigen passages (GAPs), a steady-state pathway delivering luminal antigens to LP-DCs, are inhibited during Salmonella infection. GAP inhibition was mediated by IL-1β...
February 14, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29442044/microrna-3188-targets-ets-domain-protein-4-and-participates-in-rhoa-rock-pathway-to-regulate-the-development-of-atherosclerosis
#11
Na Li, Jinghong Chen, Jingru Zhao, Tianjun Wang
We aimed to elucidate the roles and regulatory mechanism of miR-3188 in oxidized low-density lipoprotein (ox-LDL)-induced cell injury in THP-1 derived macrophages, thus providing a new insight for the treatment of atherosclerosis (AS). A total of 85 AS patients and 45 healthy controls were enrolled. The levels of miR-3188 and lipoprotein-associated phospholipase A2 (Lp-PLA2) in AS patients and healthy controls were detected. Then ox-LDL was used to treat human THP-1 derived macrophages. The effects of overexpression and suppression of miR-3188 on regulating ox-LDL-induced cell injury in THP-1 derived macrophages were investigated...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441875/influence-of-slco1b1-polymorphisms-on-atorvastatin-efficacy-and-safety-in-macedonian-subjects
#12
K Mladenovska, A Daka Grapci, M Vavlukis, A Kapedanovska, A Eftimov, N Matevska Geshkovska, D Nebija, A J Dimovski
Atorvastatin, as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is a widely prescribed medication for the treatment of dyslipidemia. However, despite its clinical efficacy in reducing major cardiovascular events, a wide inter-individual variability in its response exists. Several studies in this area point to the effect of polymorphisms in the solute carrier organic anion transporter 1B1 (SLCO1B1) gene encoding the multiple organic anion-transporting polypeptide 1B1 (OATP1B1) involved in hepatic uptake of atorvastatin...
May 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29438313/polysiloxane-polystyrene-thermo-responsive-and-self-healing-polymer-network-via-lewis-acid-lewis-base-pair-formation
#13
Fernando Vidal, Huina Lin, Cecilia Morales, Frieder Jäkle
The use of thermo-reversible Lewis Pair (LP) interactions in the formation of transient polymer networks is still greatly underexplored. In this work, we describe the synthesis and characterization of polydimethylsiloxane/polystyrene (PDMS/PS) blends that form dynamic Lewis acid-Lewis base adducts resulting in reversible crosslinks. Linear PS containing 10 mol % of di-2-thienylboryl pendant groups randomly distributed was obtained in a two-step one-pot functionalization reaction from silyl-functionalized PS, while ditelechelic PDMS with pyridyl groups at the chain-termini was directly obtained via thiol-ene "click" chemistry from commercially available vinyl-terminated PDMS...
February 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29436406/management-of-suspected-paediatric-meningitis-a-multicentre-prospective-cohort-study
#14
Roshan Ramasamy, Louise Willis, Seilesh Kadambari, Dominic F Kelly, Paul T Heath, Simon Nadel, Andrew J Pollard, Manish Sadarangani
OBJECTIVE: To quantify delays during management of children with suspected meningitis. DESIGN: Multicentre prospective cohort study. SETTING: Three UK tertiary paediatric centres; June 2011-June 2012 PATIENTS: 388 children aged <16 years hospitalised with suspected meningitis or undergoing lumbar puncture (LP) during sepsis evaluation. MAIN OUTCOME MEASURES: Time of prehospital and in-hospital assessments, LP, antibiotic treatment and discharge; types of prehospital medical assessment and microbiological results...
February 7, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29436197/the-role-of-serotonin-in-ventricular-repolarization-in-pregnant-mice
#15
Shanyu Cui, Hyewon Park, Hyelim Park, Dasom Mun, Seung Hyun Lee, Hyoeun Kim, Nuri Yun, Hail Kim, Michael Kim, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung
PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role in mothers remains unclear. We evaluated the role of serotonin in ventricular repolarization in mice hearts via 5Htr3 receptor (Htr3a) and investigated the mechanism of QT-prolongation during pregnancy. MATERIALS AND METHODS: We measured current amplitudes and the expression levels of voltage-gated K⁺ (Kv) channels in freshly-isolated left ventricular myocytes from wild-type non-pregnant (WT-NP), late-pregnant (WT-LP), and non-pregnant Htr3a homozygous knockout mice (Htr3a(-/-)-NP)...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29436013/time-resolved-fluorescence-spectroscopy-for-the-diagnosis-of-oral-lichen-planus
#16
D Gorpas, P Davari, J Bec, M A Fung, L Marcu, D G Farwell, N Fazel
BACKGROUND: Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy. AIM: To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa. METHODS: In this pilot study, measurements of lesional and perilesional buccal and mouth floor mucosa were conducted in vivo with a TRFS system...
February 13, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29435078/gene-expression-analyses-associated-with-malignant-phenotypes-of-metastatic-sub-clones-derived-from-a-mouse-oral-squamous-cell-carcinoma-sq-1979-cell-line
#17
Mitsutaka Adachi, Masako Mizuno-Kamiya, Eiji Takayama, Harumi Kawaki, Toshihiro Inagaki, Shigeki Sumi, Masayuki Motohashi, Yasunori Muramatsu, Shin-Ichiro Sumitomo, Michio Shikimori, Yutaka Yamazaki, Nobuo Kondoh
To elucidate the genetic events that occur during the development of OSCC, the present study established a model of oral malignancy using a mouse oral squamous cell carcinoma (OSCC) Sq-1979 cell line. Sq-1979 cells were implanted into syngeneic C3H mice. Subsequently, 233 cells and metastatic sub-clones (L cells) from primary OSCC, as well as the metastasized lymph node tissues of Sq-1979-implanted mice were established. Compared with parental Sq-1979 and 233 cells, the majority of L cells exhibited a higher proliferation rate and transplantability, and conferred a lower survival rate on the implanted mice...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434971/development-and-in-vitro-evaluation-of-mucoadhesive-patches-of-methotrexate-for-targeted-delivery-in-oral-cancer
#18
Bao-Zhong Jin, Xiao-Qi Dong, Xin Xu, Feng-He Zhang
The present study focused on the development of a mucoadhesive patch of methotrexate (MTX) for targeted delivery in oral cancer. Initially, MTX-loaded liposomes were prepared using the thin film hydration method, and had a mean diameter of 105.7-137.4 nm and percentage entrapment efficiency of 54.6±3.5. These liposomes were cast in optimized mucoadhesive film. The film was characterized by its release pattern, thickness, weight and percentage swelling index and the sustained release profile of the optimized film was evaluated...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434593/-leishmania-donovani-inhibitor-of-serine-peptidases-2-mediated-inhibition-of-lectin-pathway-and-upregulation-of-c5ar-signaling-promote-parasite-survival-inside-host
#19
Sudha Verma, Abhishek Mandal, Md Yousuf Ansari, Ajay Kumar, Kumar Abhishek, Ayan Kumar Ghosh, Ashish Kumar, Vinod Kumar, Sushmita Das, Pradeep Das
Leishmania donovani , the causative agent of Indian visceral leishmaniasis has to face several barriers of the immune system inside the mammalian host for its survival. The complement system is one of the first barriers and consists of a well-balanced network of proteases including S1A family serine proteases (SPs). Inhibitor of serine peptidases (ISPs) is considered as inhibitor of S1A family serine peptidases and is reported to be present in trypanosomes, including Leishmania . In our previous study, we have deciphered the role of ISPs [LdISP1 and L...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29433333/growth-performance-duodenal-morphology-and-the-caecal-microbial-population-in-female-broiler-chickens-fed-glycine-fortified-low-protein-diets-under-heat-stress-conditions
#20
Elmutaz Awad, Zulkifli Idrus, Abdoreza Soleimani Farjam, Alhassan O Bello, M Faseleh-Jahromi
1. This study was undertaken to examine the effect of feeding glycine (Gly)-fortified low protein diets on the growth performance, duodenal morphology and caecal microbial populations of broiler chickens raised under unheated, cyclic or constant heat stress environmental conditions. 2. From d 1 - 21 (starter phase), an equivalent number of birds were fed either a normal protein (NP) diet or a low protein (LP) diet fortified with Gly. From d 22 - 42 (grower phase), an equivalent number of birds from each starter diet were distributed to one of the following dietary groups: (1) a normal protein diet during the starter and grower phases (NPNP), (2) a normal protein diet during the starter phase and a low protein diet during the grower phase (NPLP), (3) a low protein diet during the starter phase and a normal protein diet during the grower phase (LPNP) or (4) low protein diets during both phases (LPLP)...
February 13, 2018: British Poultry Science
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