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https://www.readbyqxmd.com/read/29471052/revisiting-rabies-virus-neutralizing-antibodies-through-infecting-balb-c-mice-with-live-rabies-virus
#1
Yunlong Qin, Todd G Smith, Felix Jackson, Nadia F Gallardo-Romero, Clint N Morgan, Victoria Olson, Christina L Hutson, Xianfu Wu
This study investigates the production of rabies virus (RABV) neutralizing antibody after virus infection through a mouse model. The BALB/c mice from different age groups (three, five, seven week old) were intramuscularly inoculated with live rabies virus (TX coyote 323R). Without pre-exposure or post-exposure prophylaxis (PEP), we found there is a decreased fatality with increased age of animals, the mortalities are 60%, 50%, and 30%, respectively. Interestingly, through assay of rapid fluorescent focus inhibition test (RFFIT), direct fluorescent antibody (DFA) and quantitative Polymerase Chain Reaction (qPCR), the results showed that all the animals that succumbed to rabies challenge, except one, developed circulating neutralizing antibodies, and all the healthy animals, except two, did not generate virus neutralizing antibodies (VNA)...
February 19, 2018: Virus Research
https://www.readbyqxmd.com/read/29470317/the-effects-of-leukocyte-filtration-on-cell-salvaged-autologous-blood-transfusion-on-lung-function-and-lung-inflammatory-and-oxidative-stress-reactions-in-elderly-patients-undergoing-lumbar-spinal-surgery
#2
Lili Xu, Jianjun Shen, Jianliang Sun, Patrick M McQuillan, Zhiyong Hu
BACKGROUND: This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. MATERIALS AND METHODS: Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T0), immediately before blood transfusion (T1), and 1 (T2), 6 (T3), and 12 hours (T4) after end of blood transfusion...
February 21, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29469186/serum-brain-derived-neurotrophic-factor-in-children-with-coeliac-disease
#3
Daphne Margoni, Kelly Michalakakou, Eleni Angeli, Panagiota Pervanidou, Christina Kanaka-Gantenbein, George Chrousos, Ioannis Papassotiriou, Eleftheria Roma
BACKGROUND: Brain-derived Neurotrophic Factor (BDNF) is a neurotrophin that has a protective role in the nervous system and is involved in neural plasticity. It is abundant in the central nervous system, but is also expressed in the gastrointestinal tract. Coeliac disease (CD), characterized by intestinal inflammation, has some co-morbidity with neurologic and mental disorders. The aim of this study was to evaluate circulating BDNF concentrations in patients with CD at diagnosis or on a Gluten Free Diet (GFD) for longer than one year and in healthy controls (HC)...
February 22, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29469009/dairy-consumption-and-inflammatory-profile-a-cross-sectional-population-based-study-s%C3%A3-o-paulo-brazil
#4
Tábata Natal Gadotti, Marina Maintinguer Norde, Marcelo Macedo Rogero, Mauro Fisberg, Regina Mara Fisberg, Erica Oki, Lígia Araújo Martini
OBJECTIVES: The aim of this study was to investigate the association between dairy product consumption and plasma inflammatory biomarkers levels among a representative sample of Brazilian adults from São Paulo City. METHODS: Data were acquired from the Health Survey for São Paulo, a cross-sectional population-based study. All individuals 20 to 59 y of age with complete food consumption information (24-h dietary recall and food frequency questionnaire) and blood sample analysis were included (N = 259)...
October 26, 2017: Nutrition
https://www.readbyqxmd.com/read/29468638/accuracy-of-point-of-care-hba1c-testing-in-pregnant-women
#5
Katherine Culliney, Lesley M E McCowan, Karaponi Okesene-Gafa, Rinki Murphy, Janet Rowan, Rennae S Taylor, Christopher J D Mckinlay
BACKGROUND: In New Zealand, it is recommended that all pregnant women have a haemoglobin A1c (HbA1c) test performed with their booking antenatal bloods to identify previously unrecognised diabetes. However, screening rates in some groups are low. Use of a point-of-care device may improve compliance with screening. AIM: To assess the accuracy of the COBAS b101 point-of-care system referenced against a laboratory method, for measurement of HbA1c levels in pregnant women...
February 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29468287/pickering-emulsion-for-liver-trans-arterial-chemo-embolization-with-oxaliplatin
#6
Frederic Deschamps, Kathleen R Harris, Laurence Moine, Weiguo Li, Lambros Tselikas, Thomas Isoardo, Robert J Lewandowski, Angelo Paci, Nicolas Huang, Thierry de Baere, Riad Salem, Andrew C Larson
PURPOSE: Biodegradable polylactic-co-glycolic acid (PLGA) nanoparticles can adsorb at the water/oil interface to stabilize the emulsion (forming Pickering-emulsion). The purpose of this study was to compare the release profiles of oxaliplatin from Pickering-emulsion and Lipiodol-emulsion. MATERIALS/METHODS: Pickering-emulsions and Lipiodol-emulsions were both formulated with oxaliplatin (5 mg/mL) and Lipiodol (water/oil ratio: 1/3). For Pickering-emulsion only, PLGA nanoparticles (15 mg/mL) were dissolved into oxaliplatin before formulation...
February 21, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29468144/vaccine-mediated-mechanisms-controlling-replication-of-francisella-tularensis-in-human-peripheral-blood-mononuclear-cells-using-a-co-culture-system
#7
Kjell Eneslätt, Igor Golovliov, Patrik Rydén, Anders Sjöstedt
Cell-mediated immunity (CMI) is normally required for efficient protection against intracellular infections, however, identification of correlates is challenging and they are generally lacking. Francisella tularensis is a highly virulent, facultative intracellular bacterium and CMI is critically required for protection against the pathogen, but how this is effectuated in humans is poorly understood. To understand the protective mechanisms, we established an in vitro co-culture assay to identify how control of infection of F...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29467598/an-attempt-to-induce-an-immunomodulatory-effect-in-rowers-with-spirulina-extract
#8
Artur Juszkiewicz, Piotr Basta, Elżbieta Petriczko, Bogusław Machaliński, Jerzy Trzeciak, Karolina Łuczkowska, Anna Skarpańska-Stejnborn
Background: The aim of this study was to analyze the response of selected components of the immune system in rowers to maximal physical exercise, and to verify if this response can be modulated by supplementation with spirulina (cyanobacterium Spirulina platensis ) . Method: The double-blind study included 19 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group ( n  = 10), receiving 1500 mg of spirulina extract for 6 weeks, or to the placebo group ( n  = 9)...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29467015/prevention-of-disease-progression-in-leishmania-infantum-infected-dogs-with-dietary-nucleotides-and-active-hexose-correlated-compound
#9
Sergi Segarra, Guadalupe Miró, Ana Montoya, Luis Pardo-Marín, Joan Teichenné, Lluís Ferrer, José Joaquín Cerón
BACKGROUND: The prevalence of Leishmania infantum infection in clinically healthy dogs can be several times higher than that of clinical disease in endemic areas. Although treatment is not recommended in dogs with subclinical infection, these animals should be managed to prevent disease progression and parasite transmission to human beings or to other dogs. Dietary nucleotides and active hexose correlated compound (AHCC) have been shown to modulate the immune response. A recent study in dogs with clinical leishmaniosis receiving an initial 28-day course of methylglucamine antimoniate showed that six-month administration of a dietary supplement containing nucleotides plus AHCC achieves similar efficacy to allopurinol...
February 21, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29466996/-just-because-she-s-young-it-doesn-t-mean-she-has-to-die-exploring-the-contributing-factors-to-high-maternal-mortality-in-adolescents-in-eastern-freetown-a-qualitative-study
#10
Lucy November, Jane Sandall
BACKGROUND: In Sierra Leone, 34% of pregnancies and 40% of maternal deaths are in the adolescent population. Risks are known to be higher for younger adolescents, this being borne out by a household survey in Eastern Freetown in 2015. This current qualitative study, funded by Wellbeing of Women's international midwifery fellowship, was conducted to explore the causes of this high incidence of maternal death for younger teenagers, and to identify possible interventions to improve outcomes...
February 21, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29466485/autonomic-and-vascular-control-in-prehypertensive-subjects-with-a-family-history-of-arterial-hypertension
#11
Josária Ferraz Amaral, Diana de Medeiros Andrade Borsato, Isabelle Magalhães Guedes Freitas, Edgar Toschi-Dias, Daniel Godoy Martinez, Mateus Camaroti Laterza
BACKGROUND: Individuals with a family history of systemic arterial hypertension (FHSAH) and / or prehypertension have a higher risk of developing this pathology. OBJECTIVE: To evaluate the autonomic and vascular functions of prehypertensive patients with FHSAH. METHODS: Twenty-five young volunteers with FHSAH, 14 normotensive and 11 prehypertensive subjects were submitted to vascular function evaluation by forearm vascular conductance(VC) during resting and reactive hyperemia (Hokanson®) and cardiac and peripheral autonomic modulation, quantified, respectively, by spectral analysis of heart rate (ECG) and systolic blood pressure (SBP) (FinometerPRO®)...
February 19, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29466196/-issues-of-adipokine-regulation-in-idiopathic-pulmonary-arterial-hypertension-and-systemic-osteopenia
#12
E A Kochetkova, V A Nevsorova, L G Ugay, Y V Maystrovskaya, T A Brodskaya
PURPOSE: to determine the role of adipokines and vascular remodeling in formation of osteoporosis in idiopathic pulmonary arterial hypertension (IPAH). MATERIALS AND METHODS: Functional and hemodynamic parameters, bone mineral density (BMD) T-score in lumbar spine (LS) and femoral neck (FN), blood serum levels of leptin, adiponectin, visfatin and endothelin-1 were measured in 27 patients with severe IPAH and 30 healthy volunteers. RESULTS: Half of IPAH patients had osteoporosis...
February 2018: Kardiologiia
https://www.readbyqxmd.com/read/29466087/rat-hippocampal-ca3-neuronal-injury-induced-by-limb-ischemia-reperfusion-a-possible-restorative-effect-of-alpha-lipoic-acid
#13
Ola A Hussein, Amel M M Abdel-Hafez, Ayat Abd El Kareim
Limb ischemia reperfusion (I/R) injury is associated with serious local and systemic effects. Reperfusion may augment tissue injury in excess of that produced by ischemia alone. The hippocampus has been reported to be vulnerable to I/R injury. Alpha lipoic acid (ALA) is an endogenous antioxidant with a powerful antioxidative, anti-inflammatory, and antiapoptotic properties. We studied the probable restorative effect of ALA on limb I/R-induced structural damage of rat hippocampus. Forty adult male albino rats were divided equally into four groups: group I (sham); group II (I/R-1 day) has undergone bilateral femoral arteries occlusion (3 h), then reperfusion for 1 day; group III (I/R-7 days) has undergone reperfusion for seven days; group IV (I/R-ALA) has undergone I/R as group III and received an intraperitoneal injection of ALA (100 mg/kg) for 7 days...
March 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29465198/-epistaxis-during-nasotracheal-intubation-attila-s-syndrome
#14
Zaycev A Yu, Svetlov V A, Dubrovin K V, Khrustaleva M V, Dehtjar M A, Titova I V
BACKGROUND: Nasal bleeding is a common complication during nasotracheal intubation (NTI). This is due to the ana- tomical prerequisites and the hemostatic system failure. Using of various research methods in practice can reduce the frequency of such complications. The purpose of the study is to identify predictors of high probability of epistaxis associated with the NTI and the pecu- liarities of the anatomical mucous membrane structure of the nasal passages, and to assess significance of blood coag- ulationfailures in these cases...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29465099/is-it-safe-to-use-gadolinium-based-contrast-agents-in-mri
#15
R Pullicino, K Das
Gadolinium-based contrast agents have greatly expanded the capability of magnetic resonance imaging and have been used extensively in neuroradiology over the past 30 years. When initially developed they were thought to be relatively harmless; it was later discovered they are associated with nephrogenic systemic fibrosis and should be used with caution in certain patient groups, especially those with renal failure. Lately it has been found that the use of these contrast agents may result in deposition of gadolinium in the brain even in patients with an intact blood-brain barrier...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29464314/activation-status-of-peripheral-blood-neutrophils-and-the-complement-system-in-adult-rheumatoid-arthritis-patients-undergoing-combined-therapy-with-infliximab-and-methotrexate
#16
Larissa F Marchi, Adriana B Paoliello-Paschoalato, Renê D R Oliveira, Ana Elisa C S Azzolini, Luciana M Kabeya, Eduardo A Donadi, Yara Maria Lucisano-Valim
We examined the functional activity of peripheral blood neutrophils and the complement system activation status in patients with rheumatoid arthritis (RA) undergoing infliximab/methotrexate combined therapy. We studied female RA patients under treatment with infliximab (3-5 mg/kg) and methotrexate (15-25 mg/week) who presented inactive (i-RA; n = 34, DAS-28 ≤ 2.6) or at least moderately active disease (a-RA; n = 29, DAS-28 > 3.2), and age-matched healthy women (n = 38). We measured the levels of reactive oxygen species (ROS) generation (chemiluminescence assay) and membrane expression of FcγRIIa/CD32, FcγRIIIb/CD16, CR1/CD35, and CR3/CD11b receptors (ELISA assay) in neutrophils...
February 20, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29463988/sustained-release-of-immunosuppressant-by-nanoparticle-anchoring-hydrogel-scaffold-improved-the-survival-of-transplanted-stem-cells-and-tissue-regeneration
#17
Ruixiang Li, Jianming Liang, Yuwei He, Jing Qin, Huining He, Seungjin Lee, Zhiqing Pang, Jianxin Wang
The outcome of scaffold-based stem cell transplantation remains unsatisfied due to the poor survival of transplanted cells. One of the major hurdles associated with the stem cell survival is the immune rejection, which can be effectively reduced by the use of immunosuppressant. However, ideal localized and sustained release of immunosuppressant is difficult to be realized, because it is arduous to hold the drug delivery system within scaffold for a long period of time. In the present study, the sustained release of immunosuppressant for the purpose of improving the survival of stem cells was successfully realized by a nanoparticle-anchoring hydrogel scaffold we developed...
2018: Theranostics
https://www.readbyqxmd.com/read/29463395/-cardiovascular-protection-of-diabetic-patient-with-chronic-renal-disease-and-particular-case-of-end-stage-renal-disease-in-elderly-patients
#18
P Zaoui, T Hannedouche, C Combe
Type 2 diabetes has an increasing prevalence. Life expectancy is dominated by cardiovascular risk, which is the leading cause of death in these patients. Up to one third of diabetic patients will develop diabetic nephropathy related to micro-angiopathy. Renal impairment further increases cardiovascular risk. Reducing cardiovascular morbidity and mortality is a major public health issue, as well as early preventing and managing chronic kidney disease (CKD). Good glycemic control prevents the micro-vascular complications of the disease (retinopathy, nephropathy, etc...
June 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29463285/network-modules-uncover-mechanisms-of-skeletal-muscle-dysfunction-in-copd-patients
#19
Ákos Tényi, Isaac Cano, Francesco Marabita, Narsis Kiani, Susana G Kalko, Esther Barreiro, Pedro de Atauri, Marta Cascante, David Gomez-Cabrero, Josep Roca
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skeletal muscle dysfunction as a characteristic systemic effect of COPD, potentially modifiable with preventive interventions (i.e. muscle training). The research analyzes network module associated pathways and evaluates the findings using independent measurements. METHODS: We characterized the transcriptionally active network modules of interacting proteins in the vastus lateralis of COPD patients (n = 15, FEV1 46 ± 12% pred, age 68 ± 7 years) and healthy sedentary controls (n = 12, age 65 ± 9 years), at rest and after an 8-week endurance training program...
February 20, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29462939/peripheral-b-cell-subset-distribution-in-primary-antiphospholipid-syndrome
#20
Lorena Alvarez, Leyre Riancho, Jime Calvo-Alén, Marcos Lopez Hoyos, Victor Martinez-Taboada
BACKGROUND: B-cell differentiation and B-cell tolerance checkpoints may be different in antiphospholipid syndrome (APS) from systemic lupus erythematosus (SLE) and can help to understand differences between them. Our aim was to define alterations of B-cell subsets in patients with primary APS (pAPS) and to compare them with SLE patients and healthy controls (HC). METHODS: Cross-sectional study including three study groups: 37 patients with pAPS, 11 SLE patients, and 21 age- and gender-matched HC...
February 16, 2018: International Journal of Molecular Sciences
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