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https://www.readbyqxmd.com/read/28332488/parkinson-disease
#1
REVIEW
Werner Poewe, Klaus Seppi, Caroline M Tanner, Glenda M Halliday, Patrik Brundin, Jens Volkmann, Anette-Eleonore Schrag, Anthony E Lang
Parkinson disease is the second-most common neurodegenerative disorder that affects 2-3% of the population ≥65 years of age. Neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates of α-synuclein are the neuropathological hallmarks of Parkinson disease. Multiple other cell types throughout the central and peripheral autonomic nervous system are also involved, probably from early disease onwards. Although clinical diagnosis relies on the presence of bradykinesia and other cardinal motor features, Parkinson disease is associated with many non-motor symptoms that add to overall disability...
March 23, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28315150/radioiodination-and-preclinical-evaluation-of-4-benzyl-1-3-125-i-iodobenzylsulfonyl-piperidine-as-a-breast-tumor-imaging-tracer-in-mouse
#2
Masoud Sadeghzadeh, Behrouz Alirezapour, Ghorban Ali Charkhlooie, Maryam Keshavarz Baghery, Amir Khorouti
OBJECTIVE: 4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[(125)I]-iodobenzylsulfonyl)piperidine, 4-B-[(125)I]IBSP, in human ductal breast carcinoma (T47D) cells and in breast adenocarcinoma-bearing BALB/c mice are described. METHODS: Radioiodination of this new σ ligand was performed by a palladium-catalyzed stannylation approach followed by oxidative iododestannylation reaction using Iodo-Gen...
March 17, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28315063/the-effect-of-regadenoson-on-the-integrity-of-the-human-blood-brain-barrier-a-pilot-study
#3
Sadhana Jackson, Richard T George, Martin A Lodge, Anna Piotrowski, Richard L Wahl, Sachin K Gujar, Stuart A Grossman
Regadenoson is an FDA approved adenosine receptor agonist which increases blood-brain barrier (BBB) permeability in rodents. Regadenoson is used clinically for pharmacologic cardiac stress testing using SPECT or CT imaging agents that do not cross an intact BBB. This study was conducted to determine if standard doses of regadenoson transiently disrupt the human BBB allowing higher concentrations of systemically administered imaging agents to enter the brain. Patients without known intracranial disease undergoing clinically indicated pharmacologic cardiac stress tests were eligible for this study...
March 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28303161/a-systematic-review-of-intervention-studies-examining-nutritional-and-herbal-therapies-for-mild-cognitive-impairment-and-dementia-using-neuroimaging-methods-study-characteristics-and-intervention-efficacy
#4
REVIEW
Genevieve Z Steiner, Danielle C Mathersul, Freya MacMillan, David A Camfield, Nerida L Klupp, Sai W Seto, Yong Huang, Mark I Hohenberg, Dennis H Chang
Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies. The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28298042/the-effect-of-cranioplasty-following-decompressive-craniectomy-on-cerebral-blood-perfusion-neurological-and-cognitive-outcome
#5
Adnan Hussain Shahid, Manju Mohanty, Navneet Singla, Bhagwant Rai Mittal, Sunil Kumar Gupta
OBJECTIVE Decompressive craniectomy is an established therapy for refractory intracranial hypertension. Cranioplasty following decompressive craniectomy not only provides protection to the brain along with cosmetic benefits, but also enhances rehabilitation with meaningful functional recovery of potentially reversible cortical and subcortical damaged areas of the affected as well as the contralateral hemisphere. The aim of the study was to assess neurological and cognitive outcome as well as cerebral blood flow after cranioplasty...
March 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28289629/neurocognitive-dysfunction-according-to-hypoperfusion-territory-in-patients-with-moyamoya-disease
#6
Chang Gu Kang, Min Ho Chun, Jung-A Kang, Kyung Hee Do, Su Jin Choi
OBJECTIVE: To demonstrate the prevalence of cerebral hypoperfusion without focal cerebral lesions in patients with Moyamoya disease (MMD), and the relationship between areas of hypoperfusion and cognitive impairment. METHODS: Twenty-six MMD patients were included. Patients were categorized according to the presence/absence of hypoperfusion in the frontal, parietal, temporal, and occipital lobes on brain single-photon-emission computed tomography (SPECT) after acetazolamide challenge...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28283599/dopamine-transporter-imaging-does-not-predict-the-number-of-nigral-neurons-in-parkinson-disease
#7
Laura Saari, Katri Kivinen, Maria Gardberg, Juho Joutsa, Tommi Noponen, Valtteri Kaasinen
OBJECTIVE: To examine possible associations between in vivo brain dopamine transporter SPECT imaging and substantia nigra pars compacta (SNc) neuronal survival in Parkinson disease (PD). METHODS: Nigral neuron numbers were calculated for 18 patients (11 patients with neuropathologically confirmed PD) who had been examined with dopamine transporter (DAT) SPECT before death. Correlation analyses between SNc tyrosine hydroxylase (TH)-positive and neuromelanin-containing neuron counts and DAT striatal specific binding ratios (SBRs) were performed with semiquantitative region of interest-based and voxel-based analyses...
March 10, 2017: Neurology
https://www.readbyqxmd.com/read/28265641/-nuclear-medicine-in-germany-updated-key-data-and-trends-from-official-statistics
#8
Dirk Hellwig, Jörg Marienhagen, Karin Menhart, Jirka Grosse
AIM: Updated presentation of the spectrum of nuclear medicine in-vivo examinations and therapies from officially available statistics on out-patient and in-patient care as well as trends of structural data on nuclear medicine in Germany. METHODS: Data from the German Federal Health Monitoring, from the frequency statistics of the statutory health insurance for out-patients and from the German Medical Association were used and supplemented by data from selective literature searches...
March 7, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28263214/regional-cerebral-blood-flow-spect-and-mri-in-logopenic-variant-primary-progressive-aphasia
#9
Aristeidis H Katsanos, Spyridon Tsiouris, Chrissa Sioka, Anastasia Zikou, Andreas Fotopoulos
We report a 61-year-old woman who presented because of gradually progressive speech disorders. MRI scan revealed left temporal lobe atrophy with ex vacuo dilatation of the temporal horn and atrophy of the left inferior frontal gyrus and the left inferior parietal lobe. These findings in brain perfusion SPECT corresponded to a generalized hypoperfusion of the left hemisphere, particularly prominent on the rear parietal cortex and the temporal lobe. After taking into consideration the clinical presentation and imaging findings on MRI and SPECT, the diagnosis of the logopenic variant of primary progressive aphasia was finally reached...
March 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28258205/the-role-of-radionuclide-imaging-in-epilepsy-part-1-sporadic-temporal-and-extratemporal-lobe-epilepsy
#10
REVIEW
Ajay Kumar, Harry T Chugani
Epilepsy is one of the most common yet diverse neurologic disorders, affecting almost 1%-2% of the population. Presently, radionuclide imaging such as PET and SPECT is not used in the primary diagnosis or evaluation of recent-onset epilepsy. However, it can play a unique and important role in certain specific situations, such as in noninvasive presurgical localization of epileptogenic brain regions in intractable-seizure patients being considered for epilepsy surgery. Radionuclide imaging can be particularly useful if MR imaging is either negative for lesions or shows several lesions of which only 1 or 2 are suspected to be epileptogenic and if electroencephalogram changes are equivocal or discordant with the structural imaging...
March 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28256403/the-utility-of-99m-tc-dpd-scintigraphy-in-the-diagnosis-of-cardiac-amyloidosis-an-australian-experience
#11
Peter T Moore, Matthew K Burrage, Emily Mackenzie, W Philip Law, Dariusz Korczyk, Peter Mollee
BACKGROUND: The uptake of bone-seeking radiotracers in the amyloid heart is well recognised. 99(m)Tc-DPD has been shown to be highly sensitive for cardiac transthyretin (ATTR) amyloid in an overseas population, but is not registered for use in Australia. We explored its utility as a diagnostic tool within our population. METHODS: Patients diagnosed with AL and ATTR (wild-type and inherited) cardiac amyloidosis were prospectively recruited from the Princess Alexandra Hospital Amyloidosis Centre...
February 16, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28251150/a-computer-aided-analysis-method-of-spect-brain-images-for-quantitative-treatment-monitoring-performance-evaluations-and-clinical-applications
#12
Xiujuan Zheng, Wentao Wei, Qiu Huang, Shaoli Song, Jieqing Wan, Gang Huang
The objective and quantitative analysis of longitudinal single photon emission computed tomography (SPECT) images are significant for the treatment monitoring of brain disorders. Therefore, a computer aided analysis (CAA) method is introduced to extract a change-rate map (CRM) as a parametric image for quantifying the changes of regional cerebral blood flow (rCBF) in longitudinal SPECT brain images. The performances of the CAA-CRM approach in treatment monitoring are evaluated by the computer simulations and clinical applications...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28237122/a-new-era-for-nuclear-medicine-neuroimaging-in-spain-where-do-we-start-from-in-spain
#13
M A Balsa, V Camacho, P Garrastachu, D García-Solís, M Gómez-Río, S Rubí, X Setoain, J Arbizu
OBJECTIVE: To determine the status of neuroimaging studies of Nuclear Medicine in Spain during 2013 and first quarter of 2014, in order to define the activities of the neuroimaging group of the Spanish Society of Nuclear Medicine and Molecular Imaging (SEMNIM). MATERIAL AND METHODS: A questionnaire of 14 questions was designed, divided into 3 parts: characteristics of the departments (equipment and professionals involved); type of scans and clinical indications; and evaluation methods...
February 22, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28215236/hyperdopaminergism-in-lenticulostriate-stroke-related-restless-legs-syndrome-an-imaging-study
#14
Elisabeth Ruppert, Marc Bataillard, Izzie Jacques Namer, Laurent Tatu, Aurélien Hacquard, Laurence Hugueny, Jeffrey Hubbard, Ulker Kilic-Huck, Valérie Wolff, Patrice Bourgin
OBJECTIVE: The pathophysiology of restless legs syndrome (RLS) involves a dopaminergic dysregulation that remains poorly understood, with controversial data from the literature. Stroke-related RLS is a rare condition that involves primarily the basal ganglia, the paramedian pons, and the thalamus. Given these elements, we studied dopaminergic metabolism in patients with RLS secondary to lenticulostriate infarction using structural and nuclear imaging in the striatum ipsilateral to the infarction area, as compared to the contralateral side...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28211813/classification-of-depression-cognitive-disorders-and-co-morbid-depression-and-cognitive-disorders-with-perfusion-spect-neuroimaging
#15
Daniel G Amen, Pavitra Krishnamani, Somayeh Meysami, Andrew Newberg, Cyrus A Raji
BACKGROUND: Depression and cognitive disorders (CDs) are two common co-morbid afflictions that commonly present with overlapping symptoms. OBJECTIVE: To evaluate if perfusion neuroimaging with brain SPECT can distinguish persons with depression from those with CDs or both conditions. METHODS: Inclusion criteria were DSM-IV defined depression or CDs (Alzheimer's disease, vascular dementia, dementia not otherwise specified, and amnestic disorders not otherwise specified) including persons with both (total n = 4,541; 847 CDs, 3,269 depression, 425 with both)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28194630/source-based-morphometry-multivariate-approach-to-analyze-123-i-fp-cit-spect-imaging
#16
Enrico Premi, V D Calhoun, V Garibotto, R Turrone, A Alberici, E Cottini, A Pilotto, S Gazzina, M Magoni, B Paghera, B Borroni, A Padovani
PURPOSE: [(123)I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [(123)I]FP-CIT may be considered for other monoaminergic systems, in particular the serotonin transporter (SERT). Independent component analysis (ICA) implemented in source-based morphometry (SBM) could represent an alternative method to explore monoaminergic pathways, studying the relationship among voxels and grouping them into "neurotransmission" networks...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28194558/structural-imaging-of-mild-traumatic-brain-injury-may-not-be-enough-overview-of-functional-and-metabolic-imaging-of-mild-traumatic-brain-injury
#17
REVIEW
Samuel S Shin, James W Bales, C Edward Dixon, Misun Hwang
A majority of patients with traumatic brain injury (TBI) present as mild injury with no findings on conventional clinical imaging methods. Due to this difficulty of imaging assessment on mild TBI patients, there has been much emphasis on the development of diffusion imaging modalities such as diffusion tensor imaging (DTI). However, basic science research in TBI shows that many of the functional and metabolic abnormalities in TBI may be present even in the absence of structural damage. Moreover, structural damage may be present at a microscopic and molecular level that is not detectable by structural imaging modality...
February 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28190492/regional-cerebral-blood-flow-assessed-by-single-photon-emission-computed-tomography-spect-in-dogs-with-congenital-portosystemic-shunt-and-hepatic-encephalopathy
#18
Matan Or, Kathelijne Peremans, Valentine Martlé, Eva Vandermeulen, Tim Bosmans, Nausikaa Devriendt, Hilde de Rooster
Regional cerebral blood flow (rCBF) in eight dogs with congenital portosystemic shunt (PSS) and hepatic encephalopathy (HE) was compared with rCBF in eight healthy control dogs using single photon emission computed tomography (SPECT) with a (99m)technetium-hexamethylpropylene amine oxime ((99m)Tc-HMPAO) tracer. SPECT scans were abnormal in all PSS dogs. Compared to the control group, rCBF in PSS dogs was significantly decreased in the temporal lobes and increased in the subcortical (thalamic and striatal) area...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28182708/comparison-of-brain-serotonin-transporter-using-i-123-adam-between-obese-and-non-obese-young-adults-without-an-eating-disorder
#19
Chih-Hsing Wu, Chin-Sung Chang, Yen Kuang Yang, Lie-Hang Shen, Wei-Jen Yao
Cerebral serotonin metabolism has an important but controversial role in obesity. However, it is not given enough attention in morbidly obese young adults. We used single photon emission computed tomography (SPECT) with [I-123]-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) to investigate changes in serotonin transporter (SERT) availability in 10 morbidly obese young adults without an eating disorder (M/F = 5/5, body mass index (BMI): 40.3 ± 4.1 kg/m2, percentage of body fat (BF%): 46...
2017: PloS One
https://www.readbyqxmd.com/read/28174532/resting-state-brain-abnormalities-in-chronic-subjective-tinnitus-a-meta-analysis
#20
Yu-Chen Chen, Fang Wang, Jie Wang, Fan Bo, Wenqing Xia, Jian-Ping Gu, Xindao Yin
Purpose: The neural mechanisms that give rise to the phantom sound of tinnitus have not been fully elucidated. Neuroimaging studies have revealed abnormalities in resting-state activity that could represent the neural signature of tinnitus, but there is considerable heterogeneity in the data. To address this issue, we conducted a meta-analysis of published neuroimaging studies aimed at identifying a common core of resting-state brain abnormalities in tinnitus patients. Methods: A systematic search was conducted for whole-brain resting-state neuroimaging studies with SPECT, PET and functional MRI that compared chronic tinnitus patients with healthy controls...
2017: Frontiers in Human Neuroscience
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