keyword
MENU ▼
Read by QxMD icon Read
search

Proton Beam

keyword
https://www.readbyqxmd.com/read/28224302/retinal-cavernous-haemangioma-treated-by-proton-beam-therapy
#1
Amir Mahdjoubi, Rémi Dendale, Livia Lumbroso-Le Rouic, Laurence Desjardins, Nathalie Cassoux
As one of intraocular tumours, retinal cavernous haemangioma is a benign vascular lesion that is mostly unilateral. Very few cases about cavernous haemangioma treatment are reported, and there is currently no consensus on the most effective treatment. This clinical case reports on a 40-year-old male, presenting a peripheral retinal cavernous haemangioma, complicated with a repetitive vitreous haemorrhage causing bad vision. Several therapeutic methods were unsuccessfully attempted to stop haemorrhagic recurrences...
February 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28218368/intravitreal-dexamethasone-implant-ozurdex%C3%A2-for-exudative-retinal-detachment-after-proton-beam-therapy-for-choroidal-melanoma
#2
Ariane Malclès, Anh-Minh Nguyen, Thibaud Mathis, Jean-Daniel Grange, Laurent Kodjikian
PURPOSE: To evaluate the efficacy and safety of intravitreal 0.7-mg dexamethasone implant (DEX-I) (Ozurdex®) in the treatment of extensive exudative retinal detachment (RD) associated with uveal melanoma treated using proton beam therapy (PBT). METHODS: Data from 10 patients with exudative RD after PBT treated with intravitreal injection of 0.7-mg DEX-I were reviewed retrospectively. The main outcome measures were resolution of exudative RD, visual acuity, and safety profile...
February 8, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28214420/prevention-of-radiotherapy-induced-neurocognitive-dysfunction-in-survivors-of-paediatric-brain-tumours-the-potential-role-of-modern-imaging-and-radiotherapy-techniques
#3
REVIEW
Thankamma Ajithkumar, Stephen Price, Gail Horan, Amos Burke, Sarah Jefferies
Neurocognitive dysfunction is the leading cause of reduced quality of life in long-term survivors of paediatric brain tumours. Radiotherapy is one of the main contributors to neurocognitive sequelae. Current approaches for prevention and reduction of neurocognitive dysfunction include avoidance of radiotherapy in young children and reduction of the radiotherapy dose and volume of brain irradiated. Substantial advances have been made in brain imaging, especially with functional imaging and fibre tracking with the use of diffusion tensor imaging...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28214281/patient-characterization-and-usage-trends-of-proton-beam-therapy-for-localized-prostate-cancer-in-the-united-states-a-study-of-the-national-cancer-database
#4
Arya Amini, David Raben, E David Crawford, Thomas W Flaig, Elizabeth R Kessler, Elaine T Lam, Paul Maroni, Thomas J Pugh
PURPOSE: To evaluate usage trends and identify factors associated with proton beam therapy (PBT) compared to alternative forms of external beam radiation therapy (RT) (EBRT) for localized prostate cancer. PATIENTS AND METHODS: The National Cancer Database was queried for men with localized (N0, M0) prostate cancer diagnosed between 2004 and 2013, treated with EBRT, with available data on EBRT modality (photon vs. PBT). Binary multiple logistic regression identified variables associated with EBRT modality...
February 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28211796/fluence-correction-factor-for-graphite-calorimetry-in-a-clinical-high-energy-carbon-ion-beam
#5
Ana Lourenco, Russell Thomas, Michael Homer, Hugo Bouchard, Severine Rossomme, James Renaud, Tatsuaki Kanai, Gary Royle, Hugo Palmans
The aim of this work is to develop and adapt a formalism to determine absorbed dose to water from graphite calorimetry measurements in carbon-ion beams. Fluence correction factors, <i>k</i><sub>fl</sub>, needed when using a graphite calorimeter to derive dose to water, were determined in a clinical high-energy carbon-ion beam. Measurements were performed in a 290 MeV/n carbon-ion beam with a field size of 11 x 11 cm<sup>2</sup>, without modulation. In order to sample the beam, a plane-parallel Roos ionization chamber was chosen for its small collecting volume in comparison with the field size...
February 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28211717/isomeric-character-of-the-lowest-observed-4-state-in-44-s
#6
J J Parker, I Wiedenhöver, P D Cottle, J Baker, D McPherson, M A Riley, D Santiago-Gonzalez, A Volya, V M Bader, T Baugher, D Bazin, A Gade, T Ginter, H Iwasaki, C Loelius, C Morse, F Recchia, D Smalley, S R Stroberg, K Whitmore, D Weisshaar, A Lemasson, H L Crawford, A O Macchiavelli, K Wimmer
Previous experiments observed a 4^{+} state in the N=28 nucleus ^{44}S and suggested that this state may exhibit a hindered E2-decay rate, inconsistent with being a member of the collective ground state band. We populate this state via two-proton knockout from a beam of exotic ^{46}Ar projectiles and measure its lifetime using the recoil distance method with the GRETINA γ-ray spectrometer. The result, 76(14)_{stat}(20)_{syst}  ps, implies a hindered transition of B(E2;4^{+}→2_{1}^{+})=0.61(19) single-particle or Weisskopf units strength and supports the interpretation of the 4^{+} state as a K=4 isomer, the first example of a high-K isomer in a nucleus of such low mass...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211058/a-feasibility-study-of-a-hybrid-breast-immobilization-system-for-early-breast-cancer-in-proton-beam-therapy
#7
Takeshi Arimura, Takashi Ogino, Takashi Yoshiura, Mitsugi Matsuyama, Naoaki Kondo, Hideki Miyazaki, Akari Sakuragi, Takayuki Ohara, Etsuyo Ogo, Yoshio Hishikawa
PURPOSE: We aimed to develop a new breast-immobilizing system for proton beam therapy (PBT) of early breast cancer (EBC) that would provide the optimum breast shape during the treatment as well as increased fixation reliability by reducing the influence of respiratory movement. METHODS: The breast-immobilizing system (HyBIS; Hybrid Breast-Immobilizing System) consists of a whole body immobilization system (WBIS), position converting device (to change patient position), photo scanning system, breast cup (made using a three-dimensional printer), breast cup fitting apparatus, breast cup holding device (to ensure the breast remains lifted in the supine position), and dedicated stretcher fixed to the WBIS (to carry the patient)...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28202832/-prognostic-impact-of-radiation-therapy-and-molecular-classification-of-infant-atypical-teratoid-rhabdoid-tumors
#8
Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Takao Yasuhara, Kana Washio, Akira Shimada, Norihisa Katayama, Kuniaki Katsui, Hiroyuki Yanai, Isao Date
Atypical teratoid/rhabdoid tumor(AT/RT)is a rare and lethal childhood cancer. Although radiation therapy in children less than three years of age is generally deferred because of its neural toxicity, recent studies have shown that multimodal therapies, including radiation therapy, are effective in pediatric patients with AT/RT less than three years of age. We treated four infant AT/RT patients and investigated the impact of radiation therapy and genetic classification on the prognosis. The mean age at the time of the operation was 9...
February 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28198880/proton-therapy-dosimetry-using-the-scintillation-of-the-silica-fibers
#9
Arash Darafsheh, Reza Taleei, Alireza Kassaee, Jarod C Finlay
We investigate the feasibility of proton therapy dose measurement by using scintillation of a bare silica glass fiber. The emission spectra of the optical fiber at various depths in tissue-mimicking phantoms, irradiated with proton beams of energies 100-225 MeV show two distinct peaks at 460 and 650 nm whose nature is connected with the silica point defects. Our experimental results and Monte Carlo simulation showed that the Čerenkov radiation cannot be responsible for such a phenomenon. We showed that the intensity of the peak at 650 nm correlates with the proton dose with a minimal effect of ionization quenching, while the intensity peak at 460 nm under-reports the radiation dose...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28198132/clinical-results-of-proton-beam-therapy-for-hepatocellular-carcinoma-over-5%C3%A2-cm
#10
Kanako Kimura, Tatsuya Nakamura, Takashi Ono, Yusuke Azami, Motohisa Suzuki, Hitoshi Wada, Kanako Takayama, Hiromasa Endo, Teruhito Takeyama, Katsumi Hirose, Yoshihiro Takai, Yasuhiro Kikuchi
PURPOSE: This study was conducted to evaluate the safety and efficacy of proton beam therapy for large hepatocellular carcinoma (HCC). METHODS: Twenty-four patients with a HCC larger than 5.0 cm were treated with proton beam therapy at our institution between 2008 and 2015. RESULTS: The clinical stage was I in 2 patients, II in 9 patients and IIIB in 13 patients. Ten of the 24 patients were not surgical candidates because of advanced HCC or old age...
February 14, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28197927/thermodynamics-and-reaction-mechanisms-of-decomposition-of-the-simplest-protonated-tripeptide-triglycine-a-guided-ion-beam-and-computational-study
#11
Abhigya Mookherjee, Michael J Van Stipdonk, P B Armentrout
We present a thorough characterization of fragmentations observed in threshold collision-induced dissociation (TCID) experiments of protonated triglycine (H(+)GGG) with Xe using a guided ion beam tandem mass spectrometer (GIBMS). Kinetic energy-dependent cross-sections for 10 ionic products are observed and analyzed to provide 0 K barriers for six primary products: [b2](+), [y1 + 2H](+), [b3](+), CO loss, [y2 + 2H](+), and [a1](+); three secondary products: [a2](+), [a3](+), and [y2 + 2H - CO](+); and two tertiary products: high energy [y1 + 2H](+) and [a2 - CO](+) after accounting for multiple ion-molecule collisions, internal energy of reactant ions, unimolecular decay rates, competition between channels, and sequential dissociations...
February 14, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28196271/dose-distribution-at-the-bragg-peak-dose-measurements-using-ebt-and-rtqa-gafchromic-film-set-at-two-positions-to-the-central-beam-axis
#12
Borowicz Dorota Maria, Malicki Julian, Mytsin Gennady, Shipulin Konstantin
AIM: To evaluate the impact of radiochromic film positioning relative to the central beam axis (CAX) in proton beam therapy. Secondarily, to compare the dosimetric measurements obtained by RTQA and EBT film and to compare these to the doses calculated by the treatment planning system (TPS). METHODS: EBT and RTQA dosimetric radiochromic films were immersed in a water phantom and irradiated with a proton beam. The films were placed parallel to the CAX and at a 5º angle on the horizontal plane to assess the effect of film inclination on Bragg peak profiles...
February 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28182320/proton-beam-therapy-for-bone-sarcomas-of-the-skull-base-and-spine-a-retrospective-nationwide-multicenter-study-in-japan
#13
Yusuke Demizu, Masashi Mizumoto, Tsuyoshi Onoe, Naoki Nakamura, Yasuhiro Kikuchi, Tetsushi Shibata, Tomoaki Okimoto, Sakurai Hideyuki, Tetsuo Akimoto, Kota Ono, Takashi Daimon, Shigeyuki Murayama
We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (1) histologically proven bone sarcomas of the skull base or spine, (2) no metastases, (3) ≥20 years of age, and (4) no prior treatment with radiotherapy. Of the 103 patients treated between January 2004 and January 2012, we retrospectively analyzed data from 96 patients who were followed-up for >6 months or had died within 6 months...
February 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/28181780/diagnosis-treatment-clinical-course-and-prognosis-of-childhood-onset-craniopharyngioma-patients
#14
Hermann L Müller
CONTEXT: For decades gross-total resection was the preferred treatment option in childhood-onset craniopharyngioma, assuming that radical strategies at the time of initial diagnosis and treatment would result in cure. Recent reports on long-term prognosis, novel treatment approaches, and molecular genetics provide new insights into more risk-adapted treatment strategies in order to prevent sequelae such as hypothalamic syndrome. EVIDENCE ACQUISITION: A search for original articles published between 2000 and 2016 was performed in PubMed, Science Citation Index Expanded, EMBASE and Scopus...
February 9, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28167775/probing-equilibrium-of-molecular-and-deprotonated-water-on-tio2-110
#15
Zhi-Tao Wang, Yang-Gang Wang, Rentao Mu, Yeohoon Yoon, Arjun Dahal, Gregory K Schenter, Vassiliki-Alexandra Glezakou, Roger Rousseau, Igor Lyubinetsky, Zdenek Dohnálek
Understanding adsorbed water and its dissociation to surface hydroxyls on oxide surfaces is key to unraveling many physical and chemical processes, yet the barrier for its deprotonation has never been measured. In this study, we present direct evidence for water dissociation equilibrium on rutile-TiO2(110) by combining supersonic molecular beam, scanning tunneling microscopy (STM), and ab initio molecular dynamics. We measure the deprotonation/protonation barriers of 0.36 eV and find that molecularly bound water is preferred over the surface-bound hydroxyls by only 0...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28166057/proton-therapy-of-prostate-cancer-by-anterior-oblique-beams-implications-of-setup-and-anatomy-variations
#16
M Moteabbed, A Trofimov, G C Sharp, Y Wang, A L Zietman, J A Efstathiou, H-M Lu
Proton therapy of prostate by anterior beams could offer an attractive option for treating patients with hip prosthesis and limiting the high-dose exposure to the rectum. We investigated the impact of setup and anatomy variations on the anterior-oblique (AO) proton plan dose, and strategies to manage these effects via range verification and adaptive delivery. Ten patients treated by bilateral (BL) passive-scattering proton therapy (79.2 Gy in 44 fractions) who underwent weekly verification CT scans were selected...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28166055/a-comprehensive-and-efficient-daily-quality-assurance-for-pbs-proton-therapy
#17
O Actis, D Meer, S König, D C Weber, A Mayor
There are several general recommendations for quality assurance (QA) measures, which have to be performed at proton therapy centres. However, almost each centre uses a different therapy system. In particular, there is no standard procedure for centres employing pencil beam scanning and each centre applies a specific QA program. Gantry 2 is an operating therapy system which was developed at PSI and relies on the most advanced technological innovations. We developed a comprehensive daily QA program in order to verify the main beam characteristics to assure the functionality of the therapy delivery system and the patient safety system...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28162946/first-clinical-report-of-proton-beam-therapy-for-postoperative-radiotherapy-for-non-small-cell-lung-cancer
#18
Jill S Remick, Caitlin Schonewolf, Peter Gabriel, Abigail Doucette, William P Levin, John C Kucharczuk, Sunil Singhal, Taine T V Pechet, Ramesh Rengan, Charles B Simone, Abigail T Berman
BACKGROUND AND PURPOSE: The characteristic Bragg peak of proton beam therapy (PBT) allows for sparing normal tissues beyond the tumor volume that may allow for decreased toxicities associated with postoperative radiation therapy (PORT). Here we report the first institutional experience with proton therapy for PORT in patients with non-small-cell lung cancer (NSCLC) and assess early toxicities and outcomes. MATERIALS AND METHODS: We identified 61 consecutive patients treated from 2011 to 2014 who underwent PORT for locally advanced NSCLC for positive microscopic margins and/or positive N2 lymph nodes (stage III), with 27 patients receiving PBT and 34 receiving intensity-modulated radiation therapy (IMRT)...
January 5, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28157341/are-there-signatures-of-harmonic-oscillator-shells-far-from-stability-first-spectroscopy-of-110-zr
#19
N Paul, A Corsi, A Obertelli, P Doornenbal, G Authelet, H Baba, B Bally, M Bender, D Calvet, F Château, S Chen, J-P Delaroche, A Delbart, J-M Gheller, A Giganon, A Gillibert, M Girod, P-H Heenen, V Lapoux, J Libert, T Motobayashi, M Niikura, T Otsuka, T R Rodríguez, J-Y Roussé, H Sakurai, C Santamaria, N Shimizu, D Steppenbeck, R Taniuchi, T Togashi, Y Tsunoda, T Uesaka, T Ando, T Arici, A Blazhev, F Browne, A M Bruce, R Carroll, L X Chung, M L Cortés, M Dewald, B Ding, F Flavigny, S Franchoo, M Górska, A Gottardo, A Jungclaus, J Lee, M Lettmann, B D Linh, J Liu, Z Liu, C Lizarazo, S Momiyama, K Moschner, S Nagamine, N Nakatsuka, C Nita, C R Nobs, L Olivier, Z Patel, Zs Podolyák, M Rudigier, T Saito, C Shand, P-A Söderström, I Stefan, R Orlandi, V Vaquero, V Werner, K Wimmer, Z Xu
The first measurement of the low-lying states of the neutron-rich ^{110}Zr and ^{112}Mo was performed via in-beam γ-ray spectroscopy after one proton removal on hydrogen at ∼200  MeV/nucleon. The 2_{1}^{+} excitation energies were found at 185(11) keV in ^{110}Zr, and 235(7) keV in ^{112}Mo, while the R_{42}=E(4_{1}^{+})/E(2_{1}^{+}) ratios are 3.1(2), close to the rigid rotor value, and 2.7(1), respectively. These results are compared to modern energy density functional based configuration mixing models using Gogny and Skyrme effective interactions...
January 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28151727/contour-scanning-for-penumbra-improvement-in-pencil-beam-scanned-proton-therapy
#20
Gabriel Meier, Dominic Leiser, Rico Besson, Alexandre Mayor, Sairos Safai, Damien Weber, Antony Lomax
Proton therapy, especially in the form of pencil beam scanning (PBS), allows for the delivery of highly conformal dose distributions for complex tumor geometries. However, due to scattering of protons inside the patient, lateral dose gradients cannot be arbitrarily steep, which is of importance in cases with organs at risk (OARs) in close proximity to or overlapping planning target volumes (PTVs). In the PBS approach, physical pencil beams are planned using a regular grid orthogonal to the beam direction. In this work, we propose an alternative to this commonly used approach, by defining pencil beams on an irregular grid which is concentric to the target contour...
February 2, 2017: Physics in Medicine and Biology
keyword
keyword
38412
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"