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Proton Beam

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https://www.readbyqxmd.com/read/29782347/current-questions-in-bone-sarcomas
#1
Sandra J Strauss, Jeremy S Whelan
PURPOSE OF REVIEW: Osteosarcoma and Ewing sarcoma, the most common primary bone tumours in young people, are curable in most patients. However, these tumours remain a significant challenge due to the complexity and intensity of treatment and its long-term morbidity and the significant proportion of patients in whom treatment is unsuccessful. This review addresses questions about current management and emerging therapeutic targets for patients with osteosarcoma, Ewing sarcoma and chondrosarcoma, the commonest bone sarcoma but more common in older patients...
May 17, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29779919/radiation-dose-constraints-for-organs-at-risk-in-neuro-oncology-the-european-particle-therapy-network-consensus
#2
REVIEW
Maarten Lambrecht, Daniëlle B P Eekers, Claire Alapetite, Neil G Burnet, Valentin Calugaru, Ida E M Coremans, Piero Fossati, Morten Høyer, Johannes A Langendijk, Alejandra Méndez Romero, Frank Paulsen, Ana Perpar, Laurette Renard, Dirk de Ruysscher, Beate Timmermann, Pavel Vitek, Damien C Weber, Hiske L van der Weide, Gillian A Whitfield, Ruud Wiggenraad, Erik Roelofs, Petra Witt Nyström, Esther G C Troost
PURPOSE: For unbiased comparison of different radiation modalities and techniques, consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted. Following the publication of a digital, online atlas for OAR delineation in neuro-oncology by the same group, we assessed the brain OAR-dose constraints in a follow-up study. METHODS: We performed a comprehensive search to identify the current papers on OAR dose constraints for normofractionated photon and particle therapy in PubMed, Ovid Medline, Cochrane Library, Embase and Web of Science...
May 17, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29775374/new-measurement-of-the-1s-3s-transition-frequency-of-hydrogen-contribution-to-the-proton-charge-radius-puzzle
#3
Hélène Fleurbaey, Sandrine Galtier, Simon Thomas, Marie Bonnaud, Lucile Julien, François Biraben, François Nez, Michel Abgrall, Jocelyne Guéna
We present a new measurement of the 1S-3S two-photon transition frequency of hydrogen, realized with a continuous-wave excitation laser at 205 nm on a room-temperature atomic beam, with a relative uncertainty of 9×10^{-13}. The proton charge radius deduced from this measurement, r_{p}=0.877(13)  fm, is in very good agreement with the current CODATA-recommended value. This result contributes to the ongoing search to solve the proton charge radius puzzle, which arose from a discrepancy between the CODATA value and a more precise determination of r_{p} from muonic hydrogen spectroscopy...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29763970/technical-note-experimental-verification-of-magnetic-field-induced-beam-deflection-and-bragg-peak-displacement-for-mr-integrated-proton-therapy
#4
Sonja M Schellhammer, Sebastian Gantz, Armin Lühr, Bradley M Oborn, Michael Bussmann, Aswin L Hoffmann
PURPOSE: Given its sensitivity to anatomical variations, proton therapy is expected to benefit greatly from integration with magnetic resonance imaging for on-line anatomy monitoring during irradiation. Such an integration raises several challenges, as both systems mutually interact. The proton beam will experience quasi-continuous energy loss and energy-dependent electromagnetic deflection at the same time, giving rise to a deflected beam trajectory and an altered dose distribution with a displaced Bragg peak...
May 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29759487/clinical-examination-of-proton-pencil-beam-scanning-on-a-moving-anthropomorphic-lung-phantom
#5
Peng Wang, Shikui Tang, Paige A Taylor, David E Cummings, Martin Janson, Erik Traneus, Jared D Sturgeon, Andrew K Lee, Chang Chang
The objective of this study was to examine the use of proton pencil beam scanning for the treatment of moving lung tumors. A single-field uniform dose proton pencil beam scanning (PBS) plan was generated for the standard thorax phantom designed by the Imaging and Radiation Oncology Core (IROC) Houston QA Center. Robust optimization, including range and setup uncertainties as well as volumetric repainting, was used for the plan. Patient-specific quality assurance (QA) measurements were performed using both a water tank and a custom heterogeneous QA phantom...
May 11, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29755767/utilization-of-neoadjuvant-intensity-modulated-radiation-therapy-and-proton-beam-therapy-for-esophageal-cancer-in-the-united-states
#6
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
Background: Randomized esophageal cancer (EC) trials have utilized two- or three-dimensional conformal radiotherapy (3DCRT). Advanced radiotherapy (RT) techniques [(ARTs): intensity-modulated radiotherapy (IMRT) and proton beam therapy (PBT)] may have benefits, but are relatively unproven. This is the first study to date evaluating utilization of ARTs versus 3DCRT in the trimodality setting in the United States. Methods: The National Cancer Data Base (NCDB) was queried (2004-2013) for newly-diagnosed cT1b-T4bN0/N+M0 EC receiving neoadjuvant CRT followed by esophagectomy...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755733/recent-advancements-in-the-management-of-retinoblastoma-and-uveal-melanoma
#7
REVIEW
Amy C Schefler, Ryan S Kim
Retinoblastoma and uveal melanoma are the most common intraocular malignancies observed in pediatric and adult populations, respectively. For retinoblastoma, intra-arterial chemotherapy has dramatically improved treatment outcomes and eye salvage rates compared with traditional salvage rates of systemic chemotherapy and external beam radiation therapy. Intravitreal injections of chemotherapy have also demonstrated excellent efficacy for vitreous seeds. Uveal melanoma, on the other hand, is treated predominantly with iodine-125 plaque brachytherapy or with proton beam therapy...
2018: F1000Research
https://www.readbyqxmd.com/read/29754467/teaching-treatment-planning-for-protons-with-educational-open-source-software-experience-with-foca-and-matrad
#8
Daniel Sanchez-Parcerisa, Jose Udías
Open-source, MATLAB-based treatment planning systems FoCa and matRAD were used in a pilot project for training prospective medical physicists and postgraduate physics students in treatment planning and beam modeling techniques for proton therapy. In the four exercises designed, students learnt how proton pencil beams are modeled and how dose is calculated in three-dimensional voxelized geometries, how pencil beam scanning plans (PBS) are constructed, the rationale behind the choice of spot spacing in patient plans, and the dosimetric differences between photon IMRT and proton PBS plans...
May 12, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29754455/technical-note-using-dual-step-wedge-and-2d-scintillator-to-achieve-highly-precise-and-robust-proton-range-quality-assurance
#9
Wei Deng, Wei Liu, Daniel G Robertson, Martin Bues, Terence T Sio, Sameer R Keole, Jiajian Shen
PURPOSE: To develop a fast method for proton range quality assurance (QA) using a dual step-wedge and 2D scintillator and to evaluate the robustness, sensitivity, and long term reproducibility of this method. METHODS: An in-house customized dual step-wedge and a 2D scintillator were developed to measure proton ranges. Proton beams with homogenous fluence were delivered through wedge, and the images captured by the scintillator were used to calculate the proton ranges by a simple trigonometric method...
May 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29753854/occurrence-of-phosphenes-in-patients-undergoing-proton-beam-therapy-for-ocular-tumor
#10
Thibaud Mathis, Petter Hofverberg, Jean-Pierre Caujolle, Joël Hérault, Cécilia Leal, Celia Maschi, Benoit Delaunay, Stéphanie Baillif, Laurent Kodjikian, Juliette Thariat
PURPOSE: Phosphenes are frequently reported by patients irradiated in the head and neck area. The aim of the present study was to characterize and investigate potential mechanisms of proton beam therapy (PBT)-induced phosphenes in a large population of patients undergoing PBT for ocular tumors. DESIGN: Prospective cohort study METHODS: Consecutive patients who underwent PBT in a single center were included. Immediately after the first session, all patients completed a questionnaire collecting information about the presence of phosphenes as well as their color, shape, and duration...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29753334/3d-treatment-planning-system-varian-eclipse-for-proton-therapy-planning
#11
REVIEW
Narayan Sahoo, Falk Poenisch, Xiaodong Zhang, Yupeng Li, MingFu Lii, Heng Li, Archana S Gautam, Richard Wu, Michael Gillin, Xiaorong R Zhu
The capabilities of the Eclipse treatment planning system (TPS) (Varian Medical Systems, Palo Alto, CA) for proton therapy treatment planning are described. Various steps involved in the planning process to produce a 3-dimensional (3D) dose distribution both for the passive scattering and pencil beam scanning proton beam therapy are outlined. Mitigation of range and setup uncertainties through robust optimization is discussed. Use of verification plans for patient treatment field dosimetry quality assurance (QA) is presented...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29748836/simulation-study-of-dosimetric-effect-in-proton-beam-therapy-using-concomitant-boost-technique-for-unresectable-pancreatic-cancers
#12
Nobuyoshi Fukumitsu, Toshiyuki Okumura, Yuichi Hiroshima, Toshiki Ishida, Haruko Numajiri, Keiko Nemoto Murofushi, Kayoko Ohnishi, Teruhito Aihara, Hitoshi Ishikawa, Koji Tsuboi, Hideyuki Sakurai
PURPOSE: The purpose of this study is to investigate the dose distribution of proton beam therapy (PBT) using a concomitant boost technique for unresectable pancreatic cancers. MATERIALS AND METHODS: This simulation study involved 36 patients with unresectable pancreatic cancer. The irradiation dose was set as 67.5 gray equivalent (GyE) with 25 fractions using concomitant boost technique. The irradiation dose was set as 50 GyE to cover the whole target and another posterior beam of 17...
May 10, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29747928/monte-carlo-simulation-tool-for-online-treatment-monitoring-in-hadrontherapy-with-in-beam-pet-a-patient-study
#13
E Fiorina, V Ferrero, F Pennazio, G Baroni, G Battistoni, N Belcari, P Cerello, N Camarlinghi, M Ciocca, A Del Guerra, M Donetti, A Ferrari, S Giordanengo, G Giraudo, A Mairani, M Morrocchi, C Peroni, A Rivetti, M D Da Rocha Rolo, S Rossi, V Rosso, P Sala, G Sportelli, S Tampellini, F Valvo, R Wheadon, M G Bisogni
Hadrontherapy is a method for treating cancer with very targeted dose distributions and enhanced radiobiological effects. To fully exploit these advantages, in vivo range monitoring systems are required. These devices measure, preferably during the treatment, the secondary radiation generated by the beam-tissue interactions. However, since correlation of the secondary radiation distribution with the dose is not straightforward, Monte Carlo (MC) simulations are very important for treatment quality assessment...
May 7, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29747872/early-ultrasonographic-tumor-regression-after-linear-accelerator-stereotactic-fractionated-photon-radiotherapy-of-choroidal-melanoma-as-a-predictor-for-metastatic-spread
#14
Christoph Mitsch, Martin Zehetmayer, Andreas Gleiss, Dietmar Georg, Karin Dieckmann, Richard Pötter, Ramzi Sayegh, Ursula Schmidt-Erfurth, Roman Dunavoelgyi
BACKGROUND AND PURPOSE: During extended follow-up (of up to 15 years), approximately fifty percent of patients with choroidal melanoma will develop metastatic disease and eventually die. Thus, continuing research on prognostic factors, early detection and treatment is necessary. Height regression rates both after plaque brachytherapy and proton beam irradiation have been shown to have prognostic value. The purpose of this study was to analyze the influence of early tumor regression rate after treatment of choroidal melanoma with LINAC stereotactic fractionated radiotherapy (SFRT) as an independent risk factor for metastasis...
May 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29746413/intravitreal-anti-vascular-endothelial-growth-factor-treatment-at-2-month-intervals-reduces-foveal-avascular-zone-enlargement-and-vision-loss-in-radiation-maculopathy-a-pilot-study
#15
Alejandra Daruich, Alexandre Matet, Ann Schalenbourg, Leonidas Zografos
PURPOSE: To evaluate, in eyes with radiation maculopathy, the effect of 2-month-interval anti-vascular endothelial growth factor therapy on best-corrected visual acuity and foveal avascular zone (FAZ) enlargement using optical coherence tomography angiography. METHODS: Consecutive treatment-naive patients with radiation maculopathy after proton beam irradiation for choroidal melanoma were retrospectively included. Clinical and optical coherence tomography angiography data at baseline and the 6-month visit were recorded...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29744681/proton-therapy-for-head-and-neck-cancer
#16
REVIEW
Joseph K Kim, Jonathan E Leeman, Nadeem Riaz, Sean McBride, Chiaojung Jillian Tsai, Nancy Y Lee
The application of proton beam radiation therapy in the treatment of head and neck cancer has grown tremendously in the past few years. Globally, widespread interest in proton beam therapy has led to multiple research efforts regarding its therapeutic value and cost-effectiveness. The current standard of care using modern photon radiation technology has demonstrated excellent treatment outcomes, yet there are some situations where disease control remains suboptimal with the potential for detrimental acute and chronic toxicities...
May 9, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29742879/radiation-therapy-against-pediatric-malignant-central-nervous-system-tumors-embryonal-tumors-and-proton-beam-therapy
#17
REVIEW
Do Hoon Lim
Radiation therapy is highly effective for the management of pediatric malignant central nervous system (CNS) tumors including embryonal tumors. With the increment of long-term survivors from malignant CNS tumors, the radiation-related toxicities have become a major concern and we need to improve the treatment strategies to reduce the late complications without compromising the treatment outcomes. One of such strategies is to reduce the radiation dose to craniospinal axis or radiation volume and to avoid or defer radiation therapy until after the age of three...
May 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29739209/high-resolution-sub-doppler-infrared-spectroscopy-of-atmospherically-relevant-criegee-precursor-ch-2-i-radicals-ch-2-stretch-vibrations-and-charge-sloshing-dynamics
#18
A Kortyna, D M B Lesko, D J Nesbitt
The combination of a pulsed supersonic slit-discharge source and single-mode difference frequency direct absorption infrared spectroscopy permit first high resolution infrared study of the iodomethyl (CH2 I) radical, with the CH2 I radical species generated in a slit jet Ne/He discharge and cooled to 16 K in the supersonic expansion. Dual laser beam detection and collisional collimation in the slit expansion yield sub-Doppler linewidths (60 MHz), an absolute frequency calibration of 13 MHz, and absorbance sensitivities within a factor of two of the shot-noise limit...
May 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29737969/topas-geant4-configuration-for-ionization-chamber-calculations-in-proton-beams
#19
Jörg Wulff, Kilian-Simon Baumann, Nico Gerd Verbeek, Christian Baeumer, Beate Timmermann, Klemens Zink
Geant4 - as used in TOPAS - is one of the major general purpose codes suitable for investigation of ionization chambers in proton beams. To provide reliable results, the impact of parameter settings and possible limitations of the underlying condensed history (CH) algorithm need to be known.
 A version of the Fano cavity test was implemented in Geant4 (10.03.p1) for protons, which allows comparison of calculation with expected result for a typical ionization chamber-like geometry. Parameters of the CH implementation in the EMStandardOpt4 physics-list were tested...
May 8, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29735194/clinical-trial-strategies-to-compare-protons-with-photons
#20
REVIEW
Johannes A Langendijk, Liesbeth J Boersma, Coen R N Rasch, Marco van Vulpen, Johannes B Reitsma, Arjen van der Schaaf, Ewoud Schuit
The favorable beam properties of protons can be translated into clinical benefits by target dose escalation to improve local control without enhancing unacceptable radiation toxicity or to spare normal tissues to prevent radiation-induced side effects without jeopardizing local tumor control. For the clinical validation of the added value of protons to improve local control, randomized controlled trials are required. For the clinical validation of the added value of protons to prevent side effects, both model-based validation or randomized controlled trials can be used...
April 2018: Seminars in Radiation Oncology
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