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Proton Beam

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https://www.readbyqxmd.com/read/28721444/neovascular-glaucoma-after-proton-beam-therapy-of-choroidal-melanoma-incidence-and-risk-factors
#1
Aline I Riechardt, Daniel Pilger, Dino Cordini, Ira Seibel, Enken Gundlach, Annette Hager, Antonia M Joussen
PURPOSE: To analyze the risk factors for the development of neovascular glaucoma (NVG) of patients with choroidal melanoma after proton beam therapy (PBT). METHOD: Clinical case series, retrospective study. We evaluated 629 consecutive patients receiving proton beam therapy for the treatment of a choroidal melanoma at the oncology service at Charité, Berlin and Helmholtz-Zentrum, Berlin between 05/1998 and 11/2008 regarding the development and risk factors of NVG...
July 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28719019/initial-testing-of-a-pixelated-silicon-detector-prototype-in-proton-therapy
#2
Andrew J Wroe, Grant McAuley, Anthony V Teran, Jeannie Wong, Marco Petasecca, Michael Lerch, James M Slater, Anatoly B Rozenfeld
As technology continues to develop, external beam radiation therapy is being employed, with increased conformity, to treat smaller targets. As this occurs, the dosimetry methods and tools employed to quantify these fields for treatment also have to evolve to provide increased spatial resolution. The team at the University of Wollongong has developed a pixelated silicon detector prototype known as the dose magnifying glass (DMG) for real-time small-field metrology. This device has been tested in photon fields and IMRT...
July 18, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28716542/on-the-lateral-dose-profile-of-4-he-beams-in-water
#3
A Embriaco, V E Bellinzona, A Fontana, A Rotondi
PURPOSE: We investigate the possibility to improve the accuracy of the lateral dose profile for (4)He beams with a novel approach, by extending an already validated model for proton beams to heavier ions. METHODS: The full Molière theory for the Coulomb multiple scattering is applied to the case of (4)He beams, with a complete separation of the electromagnetic and of the nuclear contributions in the calculation of the total dose. The latter is described with only three free parameters...
July 14, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28714133/tilted-pillar-array-fabrication-by-the-combination-of-proton-beam-writing-and-soft-lithography-for-microfluidic-cell-capture-part-2-image-sequence-analysis-based-evaluation-and-biological-application
#4
Gabor Járvás, Tamas Varga, Marton G Szigeti, Laszlo Hajba, Peter Fürjes, Istvan Rajta, Andras Guttman
As a continuation of our previously published work, this paper presents a detailed evaluation of a microfabricated cell capture device utilizing a doubly tilted micropillar array. The device was fabricated using a novel hybrid technology based on the combination of proton beam writing and conventional lithography techniques. Tilted pillars offer unique flow characteristics and support enhanced fluidic interaction for improved immuno-affinity based cell capture. The performance of the microdevice was evaluated by an image sequence analysis based in-house developed single cell tracking system...
July 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28713989/effects-of-proton-beam-irradiation-on-mitochondrial-biogenesis-in-a-human-colorectal-adenocarcinoma-cell-line
#5
Byung Geun Ha, Sung Suk Jung, Yun Hee Shon
Proton beam therapy has recently been used to improve local control of tumor growth and reduce side-effects by decreasing the global dose to normal tissue. However, the regulatory mechanisms underlying the physiological role of proton beam radiation are not well understood, and many studies are still being conducted regarding these mechanisms. To determine the effects of proton beams on mitochondrial biogenesis, we investigated: mitochondrial DNA (mtDNA) mass; the gene expression of mitochondrial transcription factors, functional regulators, and dynamic-related regulators; and the phosphorylation of the signaling molecules that participate in mitochondrial biogenesis...
July 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28710866/response-of-synthetic-diamond-detectors-in-proton-carbon-and-oxygen-ion-beams
#6
Séverine Rossomme, Marco Marinelli, Gianluca Verona-Rinati, Francesco Romano, G A Pablo Cirrone, Andrzej Kacperek, Stefaan Vynckier, Hugo Palmans
PURPOSE: In this work, the LET-dependence of the response of synthetic diamond detectors is investigated in different particle beams. METHOD: Measurements were performed in three non-modulated particle beams (proton, carbon and oxygen). The response of five synthetic diamond detectors was compared to the response of a Markus or an Advanced Markus ionization chamber. The synthetic diamond detectors were used with their axis parallel to the beam axis and without any bias voltage...
July 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28704158/factors-associated-with-occurrence-of-radiation-induced-optic-neuropathy-at-safe-radiation-dosage
#7
Pavle Doroslovački, Madhura A Tamhankar, Grant T Liu, Kenneth S Shindler, Gui-Shuang Ying, Michelle Alonso-Basanta
BACKGROUND: Radiation-induced optic neuropathy (RION) is a rare, and often visually devastating, complication of radiation therapy (RT) near the anterior visual pathways. METHODS: A retrospective case series of patients who developed RION at a tertiary medical center, followed by a case-control study comparing RION cases with matched controls who received RT. RESULTS: Thirteen patients (18 eyes) with RION were identified. Radiation modalities included external beam photon radiation, whole brain radiation, stereotactic radiosurgery, proton beam, and unknown...
July 13, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28698447/-a-case-of-perianal-squamous-cell-carcinoma-with-left-inguinal-lymph-node-metastasis-that-showed-a-complete-response-more-than-five-years-after-chemotherapy-and-concomitant-proton-beam-therapy
#8
Nobuyasu Suzuki, Ayaka Azami, Yukitoshi Todate, Takeshi Tada, Mitsuru Waragai, Michitaka Honda, Atai Sato, Yoshinao Takano, Tsuyoshi Abe, Tatsuya Nakamura, Yasushi Teranishi
We report a case of perianal squamous cell carcinoma and left inguinal lymph node metastasis that showed a complete response more than 5 years after chemotherapy and concomitant proton beam therapy. A 34-year-old woman was referred to our hospital for an anal tumor and a left inguinal tumor. A digital rectal examination revealed a tumor in the anterior wall of the anal canal. In addition, the left inguinal lymph nodes were swollen, leading us to suspect metastases. Biopsy specimens confirmed poorly differentiated squamous cell carcinoma...
June 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28696514/modulation-of-lateral-positions-of-bragg-peaks-via-magnetic-fields-inside-cancer-patients-towards-magnetic-field-modulated-proton-therapy
#9
Wencheng Shao, Xiaobin Tang, Yanling Bai, Changran Geng, Diyun Shu, Chunhui Gong, Da Chen
PURPOSE: This work investigated whether the Bragg peak (BP) positions of proton beams can be modulated to produce uniform doses and cover a tumor under the magnetic fields inside cancer patients, and whether magnetic field modulated proton therapy (MMPT) is effective in vital organ protection. METHODS: The authors initially constructed an ideal water phantom comprising a central tumor surrounded by cuboid organ regions using GEANT4. Second, we designed the proton beams passing through the gap between two adjacent organ regions during beam configuration...
July 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28692096/a-quantum-rovibrational-state-selected-study-of-the-proton-transfer-reaction-h2-x-2-%C3%AE-v-1-3-n-0-3-ne-%C3%A2-neh-h-using-the-pulsed-field-ionization-photoion-method-observation-of-the-rotational-effect-near-the-reaction-threshold
#10
Bo Xiong, Yih-Chung Chang, Cheuk-Yiu Ng
Using the sequential electric field pulsing scheme for vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) detection, we have successfully prepared H2(+)(X(2)Σ: v(+) = 1-3; N(+) = 0-5) ions in the form of an ion beam in single quantum-rovibrational-states with high purity, high intensity, and narrow laboratory kinetic energy spread (ΔElab ≈ 0.05 eV). This VUV-PFI-PI ion source, when coupled with the double-quadrupole double-octupole ion-molecule reaction apparatus, has made possible a systematic examination of the vibrational- as well as rotational-state effects on the proton transfer reaction of H2(+)(X(2)Σ: v(+); N(+)) + Ne...
July 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28688422/an-imaging-photoelectron-photoion-coincidence-investigation-of-homochiral-2r-3r-butanediol-clusters
#11
Steven Daly, Ivan Powis, Gustavo A Garcia, Maurice Tia, Laurent Nahon
We report an experimental investigation of homochiral cluster formation in seeded molecular beam expansions of (2R,3R)-butanediol. Synchrotron radiation vacuum ultraviolet photoionization measurements have been performed using a double imaging electron-ion spectrometer in various configurations and modes of operation. These include measurements of the cluster ion mass spectra, wavelength scanned ion yields, and threshold electron spectra. Protonated cluster ions ranging up to n = 7 have been observed and size-selected photoelectron spectra and photoelectron circular dichroism (PECD) have been recorded by velocity map imaging, recorded in coincidence with ions, at a number of fixed photon energies...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28687574/successful-treatment-of-recurrent-primitive-myxoid-mesenchymal-tumor-of-infancy-with-bcor-internal-tandem-duplication
#12
Stuart L Cramer, Rong Li, Siraj Ali, Julie A Bradley, Hee K Kim, Joseph G Pressey
Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare tumor with <20 cases reported to date. Recently PMMTI tumors have been found to harbor BCOR internal tandem duplication (ITD), the same genetic alteration detected in clear cell sarcoma of the kidney (CCSK). Complete surgical resection of PMMTI is often curative, but no standard of care has been established for unresectable tumors. We describe a female patient who presented at 13 months of age with a paraspinal mass and spinal cord compression...
July 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28686884/-10-b-11-b-isotopic-ratio-and-atomic-composition-of-boron-carbide-determination-by-proton-induced-%C3%AE-ray-emission-and-proton-elastic-backscattering-spectrometry
#13
Y Sunitha, Sanjiv Kumar
The (10)B/(11)B isotopic ratio and the atomic composition of boron carbide, an important non-metallic ceramic, have been determined non-destructively by the particle induced γ-ray emission (PIGE) and elastic backscattering spectrometry (EBS) techniques with proton beams. The analysis has been performed on powder as well as sintered ceramics containing boron in natural or (10)B enriched composition. The PIGE technique, performed at a 4.0-4.2MeV proton energy, utilizes the (10)B(p,αγ)(7)Be, (10)B(p,p'γ)(10)B and (11)B(p, p'γ)(11)B nuclear reactions for (a) the isotopic analysis of boron and (b) the determination of total boron, and the (13)C(p,p'γ)(13)C nuclear reaction for the determination of carbon...
June 24, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28685904/second-hydrogen-atom-abstraction-by-molecular-ions
#14
Svetlana Tsizin, Boaz Seemann, Tal Alon, Aviv Amirav
We report the observation of a new physical phenomenon of the addition of two hydrogen atoms to molecular ions thus forming [M+2H](+) ions. We demonstrate such second hydrogen atom abstraction onto the molecular ions of pentaerythritol and trinitrotoluene (TNT). We used both GC-MS with supersonic molecular beam (SMB) with methanol added into its make-up gas and electron ionization LC-MS with SMB with methanol as the LC solvent. We found that the formation of methanol clusters resulted upon electron ionization in the formation of dominant protonated pentaerythritol ion at m/z=137 plus about 70% relative abundance of pentaerythritol molecular ion with two additional hydrogen atoms at m/z=138 which is well above the 5...
July 7, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28685076/follow-up-study-of-liver-metastasis-from-breast-cancer-treated-by-proton-beam-therapy
#15
Nobuyoshi Fukumitsu, Toshiyuki Okumura, Haruko Numajiri, Daichi Takizawa, Kayoko Ohnishi, Masashi Mizumoto, Teruhito Aihara, Hitoshi Ishikawa, Koji Tsuboi, Hideyuki Sakurai
Liver metastasis from breast cancer (LMBC) is an incurable, fatal disease with a very poor prognosis. Although various local treatments have been applied, their clinical utility has not been established. The purpose of this study was to investigate the safety and effectiveness of proton beam therapy (PBT) for the treatment of patients with LMGC. A total of 8 female patients (aged 38-63 years) with LMBC who received PBT between 2002 and 2012 were retrospectively reviewed. Patients who had tumors confined to the liver were investigated, whereas patients with extrahepatic tumors were excluded...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28682790/comparison-of-geant4-multiple-coulomb-scattering-models-with-theory-for-radiotherapy-protons
#16
Anastasia Makarova, Bernard Gottschalk, Wolfgang Sauerwein
Usually, Monte Carlo models are validated against experimental data. However, models of multiple Coulomb scattering (MCS) in the Gaussian approximation are exceptional in that we have theories which are probably more accurate than the experiments which have, so far, been done to test them. In problems directly sensitive to the distribution of angles leaving the target, the relevant theory is the Molière/Fano/Hanson variant of Molière theory (Gottschalk et al 1993 Nucl. Instrum. Methods Phys. Res. B 74 467-90)...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28678434/prospective-study-of-proton-beam-radiation-therapy-for-limited-stage-small-cell-lung-cancer
#17
Jean-Claude M Rwigema, Vivek Verma, Liyong Lin, Abigail T Berman, William P Levin, Tracey L Evans, Charu Aggarwal, Ramesh Rengan, Corey Langer, Roger B Cohen, Charles B Simone
BACKGROUND: Existing data supporting the use of proton-beam therapy (PBT) for limited-stage small cell lung cancer (LS-SCLC) are limited to a single 6-patient case series. This is the first prospective study to evaluate clinical outcomes and toxicities of PBT for LS-SCLC. METHODS: This study prospectively analyzed patients with primary, nonrecurrent LS-SCLC definitively treated with PBT and concurrent chemotherapy from 2011 to 2016. Clinical backup intensity-modulated radiotherapy (IMRT) plans were generated for each patient and were compared with PBT plans...
July 5, 2017: Cancer
https://www.readbyqxmd.com/read/28675582/optimization-of-dual-energy-ct-acquisitions-for-proton-therapy-using-projection-based-decomposition
#18
Gloria Vilches-Freixas, Jean Michel Létang, Nicolas Ducros, Simon Rit
PURPOSE: Dual-energy computed tomography (DECT) has been presented as a valid alternative to single-energy CT to reduce the uncertainty of the conversion of patient CT numbers to proton stopping power ratio (SPR) of tissues relative to water. The aim of this work was to optimize DECT acquisition protocols from simulations of X-ray images for the treatment planning of proton therapy using a projection-based dual-energy decomposition algorithm. METHODS: We have investigated the effect of various voltages and tin filtration combinations on the SPR map accuracy and precision, and the influence of the dose allocation between the low energy (LE) and the high energy (HE) acquisitions...
July 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28675445/europium-155-as-a-source-for-dual-energy-cone-beam-computed-tomography-in-adaptive-proton-therapy-a-simulation-study
#19
Jiahua Zhu, Scott N Penfold
PURPOSE: To investigate the feasibility of a 3D imaging system utilizing a (155) Eu source and pixelated cadmium-zinc-telluride (CZT) detector for applications in adaptive radiotherapy. Specifically, to compare the reconstructed stopping power ratio (SPR) values of a head phantom obtained with the proposed imaging technique with theoretical SPR values. METHOD: A Geant4 Monte Carlo simulation was performed with the novel imaging system. The simulation was repeated with a typical 120 kV X-ray tube spectrum while maintaining all other parameters...
July 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28673358/difference-in-the-relative-biological-effectiveness-and-dna-damage-repair-processes-in-response-to-proton-beam-therapy-according-to-the-positions-of-the-spread-out-bragg-peak
#20
Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara, Tetsuo Akimoto
BACKGROUND: Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the Spread-Out Bragg Peak (SOBP). Towards this end, we investigated the differences in the biological effect of a high-energy proton beam on the target cells placed at different positions on the SOBP, using two human esophageal cancer cell lines with differing radiosensitivities...
July 3, 2017: Radiation Oncology
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