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Proton Beam

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https://www.readbyqxmd.com/read/28921881/use-of-a-radial-projection-to-reduce-the-statistical-uncertainty-of-spot-lateral-profiles-generated-by-monte-carlo-simulation
#1
Xiaoning Ding, Wei Liu, Jiajian Shen, Aman Anand, Joshua B Stoker, Yanle Hu, Martin Bues
Monte Carlo (MC) simulation has been used to generate commissioning data for the beam modeling of treatment planning system (TPS). We have developed a method called radial projection (RP) for postprocessing of MC-simulation-generated data. We used the RP method to reduce the statistical uncertainty of the lateral profile of proton pencil beams with axial symmetry. The RP method takes advantage of the axial symmetry of dose distribution to use the mean value of multiple independent scores as the representative score...
September 18, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28918686/sensitivity-of-post-treatment-positron-emission-tomography-computed-tomography-to-detect-inter-fractional-range-variations-in-scanned-ion-beam-therapy
#2
Josefine Handrack, Thomas Tessonnier, Wenjing Chen, Jakob Liebl, Jürgen Debus, Julia Bauer, Katia Parodi
BACKGROUND: Ion therapy, especially with modern scanning beam delivery, offers very sharp dose gradients for highly conformal cancer treatment. However, it is very sensitive to uncertainties of tissue stopping properties as well as to anatomical changes and setup errors, making range verification highly desirable. To this end, positron emission tomography (PET) can be used to measure decay products of β(+)-emitters created in interactions inside the patient. This work investigates the sensitivity of post treatment PET/CT (computed tomography) to detect inter-fractional range variations...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28917586/dosimetric-comparison-to-the-heart-and-cardiac-substructure-in-a-large-cohort-of-esophageal-cancer-patients-treated-with-proton-beam-therapy-or-intensity-modulated-radiation-therapy
#3
Yutaka Shiraishi, Cai Xu, Jinzhong Yang, Ritsuko Komaki, Steven H Lin
PURPOSE: To compare heart and cardiac substructure radiation exposure using intensity-modulated radiotherapy (IMRT) vs. proton beam therapy (PBT) for patients with mid- to distal esophageal cancer who received chemoradiation therapy. METHODS AND MATERIALS: We identified 727 esophageal cancer patients who received IMRT (n=477) or PBT (n=250) from March 2004 to December 2015. All patients were treated to 50.4Gy with IMRT or to 50.4 cobalt Gray equivalents with PBT...
September 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28917248/stereotactic-body-radiation-therapy-for-prostate-cancer-a-review
#4
Waqar Haque, E Brian Butler, Bin S Teh
Prostate cancer can be managed with external beam radiation therapy, delivered with either protons or photons, brachytherapy, surgery, or active surveillance. Advances in imaging and radiation therapy delivery have allowed treatment of prostate cancer using ultra-hypofractionated radiation therapy with a high dose per fraction using a technique called stereotactic body radiation therapy (SBRT). While no randomized trials have compared the efficacy of SBRT to conventionally fractionated radiation therapy (CFRT), numerous prospective trials and retrospective reviews have demonstrated the safety and efficacy of SBRT for localized prostate cancer, used either definitively or as a boost along with CFRT...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28905399/microdosimetric-measurements-of-a-clinical-proton-beam-with-micrometer-sized-solid-state-detector
#5
Sarah E Anderson, Keith M Furutani, Linh T Tran, Lachlan Chartier, Marco Petasecca, Michael Lerch, Dale A Prokopovich, Mark Reinhard, Vladimir L Perevertaylo, Anatoly B Rosenfeld, Michael G Herman, Chris Beltran
PURPOSE: Microdosimetry is a vital tool for assessing the microscopic patterns of energy deposition by radiation, which ultimately govern biological effect. Solid-state, silicon-on-insulator microdosimeters offer an approach for making microdosimetric measurements with high spatial resolution (on the order of tens of micrometers). These high-resolution, solid-state microdosimeters may therefore play a useful role in characterizing proton radiotherapy fields, particularly for making highly-resolved measurements within the Bragg peak region...
September 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28890817/proton-beam-reirradiation-for-locally-recurrent-pancreatic-adenocarcinoma
#6
Pamela J Boimel, Abigail T Berman, Jonathan Li, Smith Apisarnthanarax, Stefan Both, Kristi Lelionis, Gary L Larson, Ursina Teitelbaum, John N Lukens, Edgar Ben-Josef, James M Metz, John P Plastaras
BACKGROUND: Local recurrence following definitive treatment for pancreatic adenocarcinoma is common and can be associated with significant morbidity and mortality. Retreatment options for these patients are limited. Proton beam reirradiation (PRT) may limit dose and toxicity to previously irradiated normal tissues in patients without evidence of metastatic disease. METHODS: Between 8/2010-2/2015, 15 patients with isolated, locally-recurrent pancreatic cancer were treated with PRT...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28887837/characterisation-of-proton-pencil-beam-scanning-and-passive-beam-using-a-high-spatial-resolution-solid-state-microdosimeter
#7
Linh T Tran, Lachlan Chartier, David Bolst, Alex Pogossov, Susanna Guatelli, Marco Petasecca, Michael L F Lerch, Dale A Prokopovich, Mark I Reinhard, Benjamin Clasie, Nicolas Depauw, Hanne Kooy, Jacob B Flanz, Aimee McNamara, Harald Paganetti, Chris Beltran, Keith Furutani, Vladimir L Perevertaylo, Michael Jackson, Anatoly B Rosenfeld
PURPOSE: This work aims to characterise a proton pencil-beam scanning (PBS) and passive double scattering (DS) systems as well as to measure parameters relevant to the relative biological effectiveness (RBE) of the beam using a silicon-on-insulator (SOI) microdosimeter with well-defined 3D sensitive volumes (SV). The dose equivalent downstream and laterally outside of a clinical PBS treatment field was assessed and compared to that of a DS beam. METHODS: A novel silicon microdosimeter with well-defined 3D SVs was used in this study...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28886211/homogeneity-study-of-proton-and-carbon-ion-scanning-beams-using-combinations-of-different-spot-sizes-and-grid-sizes
#8
Ying Xing, Xianwei Wu, Yongqiang Li, Jun Zhao
PURPOSE: Different scanning ion beam delivery systems have different delivery accuracies, and the resulting delivery errors will affect field homogeneity. This study was performed to determine an appropriate combination of spot size (FWHM) and spot grid size (GS), which can provide homogenous dose distributions for both proton and carbon ion scanning beam radiotherapy. The combination of the two parameters is represented by a combination factor named n, which is the quotient of FWHM divided by GS...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28885189/addendum-measurement-of-charged-particle-yields-from-pmma-irradiated-by-a-220-mev-u-sup-12-sup-c-beam
#9
Ilaria Mattei, Giuseppe Battistoni, Francesco Collini, Erika De Lucia, Marco Durante, Salvatore Fiore, Chiara Latessa, Carlo Mancini-Terracciano, Michela Marafini, Riccardo Mirabelli, Silvia Muraro, Riccardo Paramatti, Luca Piersanti, Antoni Rucinski, Andrea Russomando, Alessio Sarti, Christoph Schuy, Adalberto Sciubba, Elena Solfaroli Camillocci, Marco Toppi, Giacomo Traini, Serena Marta Valle, Marie Vanstalle, Vincenzo Patera
In this paper we report the re-analysis of the data published in (Piersanti et al. 2014) documenting the charged secondary particles production induced by the interaction of a 220 MeV/u 12C ion beam impinging on a polymethyl methacrylate (PMMA) target, measured in 2012 at the GSI facility in Darmstadt (Germany). This re-analysis takes into account the inhomogeneous light response of the LYSO crystal in the experimental setup measured in a subsequent experiment (2014) performed in the Heidelberg Ion- Beam Therapy Center...
September 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28885130/a-comparison-of-relative-proton-stopping-power-measurements-across-patient-size-using-dual-and-single-energy-ct
#10
Gregory Michalak, Vicki Taasti, Bernhard Krauss, Amanda Deisher, Ahmed Halaweish, Cynthia McCollough
PURPOSE: To evaluate the accuracy and precision across phantom size of a dual-energy computed tomography (DECT) technique used to calculate relative proton stopping power (SPR) in tissue-simulating materials and a silicone implant relative to conventional single-energy CT (SECT). MATERIAL AND METHODS: A 32 cm lateral diameter (CIRS model 062M, Norfolk, Virginia) electron density phantom containing inserts which simulated the chemical composition of eight tissues in a solid-water background was scanned using SECT and DECT...
September 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28885067/differential-gene-expression-in-primary-fibroblasts-induced-by-proton-and-cobalt-60-beam-irradiation
#11
Steffen Nielsen, Niels Bassler, Leszek Grzanka, Jan Swakon, Pawel Olko, Christian Nicolaj Andreassen, Jens Overgaard, Jan Alsner, Brita Singers Sørensen
INTRODUCTION: Proton beam therapy delivers a more conformal dose distribution than conventional radiotherapy, thus improving normal tissue sparring. Increasing linear energy transfer (LET) along the proton track increases the relative biological effectiveness (RBE) near the distal edge of the Spread-out Bragg peak (SOBP). The severity of normal tissue side effects following photon beam radiotherapy vary considerably between patients. AIM: The dual study aim was to identify gene expression patterns specific to radiation type and proton beam position, and to assess whether individual radiation sensitivity influences gene expression levels in fibroblast cultures irradiated in vitro...
September 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28884707/review-of-medical-radiography-and-tomography-with-proton-beams
#12
Robert P Johnson
The use of hadron beams, especially proton beams, in cancer radiotherapy has expanded rapidly in the past two decades. To fully realize the advantages of hadron therapy over traditional X-ray and gamma-ray therapy requires accurate positioning of the Bragg peak throughout the tumor being treated. Already a half century ago suggestions were made to use protons themselves to develop images of tumors and surrounding tissue, to be used for treatment planning. The recent global expansion of hadron therapy coupled with modern advances in computation and particle detection has led several collaborations around the world to develop prototype detector systems and associated reconstruction codes for proton computed tomography (pCT) as well as more simple proton radiography, with the ultimate intention to use such systems in clinical treatment planning and verification...
September 8, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28883747/proton-beam-therapy-in-non-small-cell-lung-cancer-state-of-the-art
#13
REVIEW
Hideyuki Harada, Shigeyuki Murayama
This review summarizes the past and present status of proton beam therapy (PBT) for lung cancer. PBT has a unique characteristic called the Bragg peak that enables a reduction in the dose of normal tissue around the tumor, but is sensitive to the uncertainties of density changes. The heterogeneity in electron density for thoracic lesions, such as those in the lung and mediastinum, and tumor movement according to respiration necessitates respiratory management for PBT to be applied in lung cancer patients. There are two types of PBT - a passively scattered approach and a scanning approach...
2017: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28883424/efficient-post-acceleration-of-protons-in-helical-coil-targets-driven-by-sub-ps-laser-pulses
#14
H Ahmed, S Kar, G Cantono, P Hadjisolomou, A Poye, D Gwynne, C L S Lewis, A Macchi, K Naughton, G Nersisyan, V Tikhonchuk, O Willi, M Borghesi
The characteristics of laser driven proton beams can be efficiently controlled and optimised by employing a recently developed helical coil technique, which exploits the transient self-charging of solid targets irradiated by intense laser pulses. Here we demonstrate a well collimated (<1° divergence) and narrow bandwidth (~10% energy spread) proton beamlet of ~10(7) particles at 10 ± 0.5 MeV obtained by irradiating helical coil targets with a few joules, sub-ps laser pulses at an intensity of ~2 × 10(19) W cm(-2)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880369/optimization-of-beam-arrangements-in-proton-minibeam-radiotherapy-by-cell-survival-simulations
#15
Matthias Sammer, Christoph Greubel, Stefanie Girst, Günther Dollinger
PURPOSE: Proton minibeam radiotherapy using sub-millimeter beam dimensions allows to enhance tissue sparing in the entrance channel by spatial fractionation additionally to advantageous proton depth dose distribution. In the entrance channel, spatial fractionation leads to reduced side effects compared to conventional proton therapy. The sub-millimeter sized beams widen with depth due to small angle scattering and enable therefore, in contrary to x-ray microbeam radiation therapy (MRT), the homogeneous irradiation of a tumor...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28880368/optimization-of-monte-carlo-particle-transport-parameters-and-validation-of-a-novel-high-throughput-experimental-setup-to-measure-the-biological-effects-of-particle-beams
#16
Darshana Patel, Lawrence Bronk, Fada Guan, Christopher R Peeler, Stephan Brons, Ivana Dokic, Amir Abdollahi, Claudia Rittmüller, Oliver Jäkel, David Grosshans, Radhe Mohan, Uwe Titt
PURPOSE: Accurate modeling of the relative biological effectiveness (RBE) of particle beams requires increased systematic in vitro studies with human cell lines with care towards minimizing uncertainties in biologic assays as well as physical parameters. In this study we describe a novel high-throughput experimental setup and an optimized parameterization of the Monte Carlo (MC) simulation technique that is universally applicable for accurate determination of RBE of clinical ion beams...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28873069/fred-a-gpu-accelerated-fast-monte-carlo-code-for-rapid-treatment-plan-recalculation-in-ion-beam-therapy
#17
A Schiavi, M Senzacqua, S Pioli, A Mairani, G Magro, S Molinelli, M Ciocca, G Battistoni, V Patera
Ion beam therapy is a rapidly growing technique for tumor radiation therapy. Ions allow for a high dose deposition in the tumor region, while sparing the surrounding healthy tissue. For this reason, the highest possible accuracy in the calculation of dose and its spatial distribution is required in treatment planning. On one hand, commonly used treatment planning software solutions adopt a simplified beam-body interaction model by remapping pre-calculated dose distributions into a 3D water-equivalent representation of the patient morphology...
September 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28871993/predicted-rate-of-secondary-malignancies-following-adjuvant-proton-versus-photon-radiation-therapy-for-thymoma
#18
J Vogel, L Lin, L A Litzky, A T Berman, C B Simone
PURPOSE: Thymic malignancies are the most common tumors of the anterior mediastinum. The benefit of adjuvant radiation therapy for stage II disease remains controversial, and patients treated with adjuvant radiation therapy are at risk of late complications, including radiation-induced secondary malignant neoplasms (SMNs), that may reduce the overall benefit of treatment. We assess the risk of predicted SMNs following adjuvant proton radiation therapy compared with photon radiation therapy after resection of stage II thymic malignancies to determine whether proton therapy improves the risk-benefit ratio...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871980/empowering-intensity-modulated-proton-therapy-through-physics-and-technology-an-overview
#19
REVIEW
Radhe Mohan, Indra J Das, Clifton C Ling
Considering the clinical potential of protons attributable to their physical characteristics, interest in proton therapy has increased greatly in this century, as has the number of proton therapy installations. Until recently, passively scattered proton therapy was used almost entirely. Notably, the overall clinical results to date have not shown a convincing benefit of protons over photons. A rapid transition is now occurring with the implementation of the most advanced form of proton therapy, intensity modulated proton therapy (IMPT)...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871342/a-systematic-review-of-publications-on-charged-particle-therapy-for-hepatocellular-carcinoma
#20
REVIEW
Hiroshi Igaki, Masashi Mizumoto, Toshiyuki Okumura, Kiyoshi Hasegawa, Norihiro Kokudo, Hideyuki Sakurai
Charged particle therapy (proton beam therapy and carbon ion therapy) is a form of radiotherapy which has the unique characteristic of superior depth dose distribution, and has been used for the treatment of hepatocellular carcinoma (HCC) in a limited number of patients, especially in Japan. We undertook a systematic review to define the clinical utility of charged particle therapy for patients with HCC. We searched the MEDLINE database from 1983 to June 2016 to identify clinical studies on charged particle therapy for HCC...
September 4, 2017: International Journal of Clinical Oncology
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