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JOURNAL ARTICLE
Onorina Laura Manzo, Jasmine Nour, Linda Sasset, Alice Marino, Luisa Rubinelli, Sailesh Palikhe, Martina Smimmo, Yang Hu, Maria Rosaria Bucci, Alain Borczuk, Olivier Elemento, Julie K Freed, Giuseppe Danilo Norata, Annarita Di Lorenzo
BACKGROUND: Growing evidence correlated changes in bioactive sphingolipids, particularly S1P (sphingosine-1-phosphate) and ceramides, with coronary artery diseases. Furthermore, specific plasma ceramide species can predict major cardiovascular events. Dysfunction of the endothelium lining lesion-prone areas plays a pivotal role in atherosclerosis. Yet, how sphingolipid metabolism and signaling change and contribute to endothelial dysfunction and atherosclerosis remain poorly understood...
March 8, 2024: Circulation Research
#22
JOURNAL ARTICLE
A B Delogu, C Aliberti, L Birritella, G De Rosa, C De Rose, R Morello, N Cambise, A G Marino, A Belmusto, L Tinti, A Di Renzo, G A Lanza, D Buonsenso
Although the mechanisms underlying the pathophysiology of long COVID condition are still debated, there is growing evidence that autonomic dysfunction may play a role in the long-term complications or persisting symptoms observed in a significant proportion of patients after SARS-CoV-2 infection. However, studies focused on autonomic dysfunction have primarily been conducted in adults, while autonomic function has not yet been investigated in pediatric subjects. In this study, for the first time, we assessed whether pediatric patients with long COVID present abnormalities in autonomic cardiac function...
March 6, 2024: European Journal of Pediatrics
#23
JOURNAL ARTICLE
Simone Parisi, Becciolini Andrea, Ditto Maria Chiara, Lo Gullo Alberto, Larosa Maddalena, Scolieri Palma, Addimanda Olga, Reta Massimo, Paroli Marino, Caccavale Rosalba, Visalli Elisa, Foti Rosario, Amato Giorgio, De Lucia Francesco, Dal Bosco Ylenia, Foti Roberta, Farina Antonella, Girelli Francesco, Bernardi Simone, Camellino Dario, Bianchi Gerolamo, Colina Matteo, Andracco Romina, Mansueto Natalia, Ferrero Giulio, Del Medico Patrizia, Molica Colella Aldo, Franchina Veronica, Molica Colella Francesco, Lumetti Federica, Sandri Gilda, Salvarani Carlo, Priora Marta, Ianniello Aurora, Nucera Valeria, Santilli Daniele, Lucchini Gianluca, Giuditta Adorni, Di Donato Eleonora, Bravi Elena, Platè Ilaria, Arrigoni Eugenio, Bezzi Alessandra, Focherini Maria Cristina, Mascella Fabio, Bruzzese Vincenzo, Ravagnani Viviana, Fiorenza Alessia, Rovera Guido, Vitetta Rosetta, Marchetta Antonio, Volpe Alessandro, Ometto Francesca, Ariani Alarico, Fusaro Enrico
OBJECTIVES: The persistence in therapy of rheumatoid arthritis drugs and particularly bDMARD is a limiting factor for their long-term use. The randomized controlled trials (RCTs) may not reflect real-world contexts due to strict inclusion and exclusion criteria. Baricitinib, which targets both JAK1 and JAK2, has been used in Italy for several years. The aim of this multi-center study is to assess the real world persistence on therapy of baricitinib in RA patients and to identify predictive factors of baricitinib's survival rate...
2024: Curr Res Pharmacol Drug Discov
#24
JOURNAL ARTICLE
Rodrigo J Mariño, Sergio E Uribe, Rebecca Chen, Falk Schwendicke, Nicolas Giraudeau, Janneke F M Scheerman
OBJECTIVE: Authors reported multiple definitions of e-oral health and related terms, and used several definitions interchangeably, like mhealth, teledentistry, teleoral medicine and telehealth. The International Association of Dental Research e-Oral Health Network (e-OHN) aimed to establish a consensus on terminology related to digital technologies used in oral healthcare. METHOD: The Crowdsourcing Delphi method used in this study comprised of four main stages. In the first stage, the task force created a list of terms and definitions around digital health technologies based on the literature and established a panel of experts...
February 28, 2024: BMC Oral Health
#25
JOURNAL ARTICLE
Patricia A Carney, Marie B Engstrom, Chrystal Barnes, NithyaPriya Ramalingam, Caitlin Dickinson, Cort Cox, Laura K Ferrara, Paul M Darden, Lyle J Fagnan, Miguel Marino, Brigit A Hatch
INTRODUCTION/OBJECTIVES: With growing vaccination misinformation and mistrust, strategies to improve vaccination communication across community-based settings are needed. METHODS: The Rural Adolescent Vaccine Enterprise (RAVE), a 5-year (2018-2022) stepped-wedge cluster randomized study, tested a clinic-based practice facilitation intervention designed to improve HPV vaccination. An exploratory aim sought to explore the use of partnerships between primary care clinics and a community partner of their choosing, to implement a social marketing campaign related to HPV immunization...
2024: Journal of Primary Care & Community Health
#26
JOURNAL ARTICLE
Enhanced pro-apoptotic activity of rituximab through IBTK silencing in non-Hodgkin lymphoma B-cells.
Eleonora Vecchio, Rossana Marino, Selena Mimmi, Camilla Canale, Carmen Caiazza, Alessandro Arcucci, Maria Rosaria Ruocco, Marco Schiavone, Gianluca Santamaria, Camillo Palmieri, Enrico Iaccino, Massimo Mallardo, Ileana Quinto, Giuseppe Fiume
Rituximab is a commonly used chemotherapeutic drug for patients with aggressive lymphomas, such as non-Hodgkin's lymphoma (NHL). Currently, the combination of Rituximab and chemotherapy (R-CHOP) stands as the most prevalent first-line therapy for NHL. Nevertheless, the development of new therapeutic approaches remains imperative. An increasing body of evidence highlights a novel role for IBTK in tumorigenesis and cancer growth. In this study, we aim to broaden our understanding of IBTK's function in B-lymphoma, with a particular focus on its impact on the expression of the oncogene MYC...
2024: Frontiers in Oncology
#27
JOURNAL ARTICLE
Francesca Petralia, Weiping Ma, Tomer M Yaron, Francesca Pia Caruso, Nicole Tignor, Joshua M Wang, Daniel Charytonowicz, Jared L Johnson, Emily M Huntsman, Giacomo B Marino, Anna Calinawan, John Erol Evangelista, Myvizhi Esai Selvan, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Xiaoyu Song, Berk Turhan, Karen E Christianson, David A Lewis, Eden Z Deng, Daniel J B Clarke, Jeffrey R Whiteaker, Jacob J Kennedy, Lei Zhao, Rossana Lazcano Segura, Harsh Batra, Maria Gabriela Raso, Edwin Roger Parra, Rama Soundararajan, Ximing Tang, Yize Li, Xinpei Yi, Shankha Satpathy, Ying Wang, Maciej Wiznerowicz, Tania J González-Robles, Antonio Iavarone, Sara J C Gosline, Boris Reva, Ana I Robles, Alexey I Nesvizhskii, D R Mani, Michael A Gillette, Robert J Klein, Marcin Cieslik, Bing Zhang, Amanda G Paulovich, Robert Sebra, Zeynep H Gümüş, Galen Hostetter, David Fenyö, Gilbert S Omenn, Lewis C Cantley, Avi Ma'ayan, Alexander J Lazar, Michele Ceccarelli, Pei Wang
Despite the successes of immunotherapy in cancer treatment over recent decades, less than <10%-20% cancer cases have demonstrated durable responses from immune checkpoint blockade. To enhance the efficacy of immunotherapies, combination therapies suppressing multiple immune evasion mechanisms are increasingly contemplated. To better understand immune cell surveillance and diverse immune evasion responses in tumor tissues, we comprehensively characterized the immune landscape of more than 1,000 tumors across ten different cancers using CPTAC pan-cancer proteogenomic data...
February 29, 2024: Cell
#28
JOURNAL ARTICLE
Irene Paterniti, Sarah Adriana Scuderi, Lucia Cambria, Antonia Nostro, Emanuela Esposito, Andreana Marino
Probiotic therapy needs consideration as an alternative strategy to prevent and possibly treat corneal infection. This study aimed to assess the preventive effect of Lactobacillus reuteri and Bifidobacterium longum subsp. infantis on reducing the infection of human corneal epithelial (HCE) cells caused by Pseudomonas aeruginosa . The probiotics' preventive effect against infection was evaluated in cell monolayers pretreated with each probiotic 1 h and 24 h prior to P. aeruginosa challenge followed by 1 h and 24 h of growth in combination...
February 1, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Chiara Mapelli, Elisabetta Miserocchi, Marco Nassisi, Gisella B Beretta, Luca Marelli, Gaia Leone, Achille Marino, Cecilia Chighizola, Gilberto Cincinelli, Teresa Giani, Paolo Nucci, Francesco Viola, Giovanni Filocamo, Francesca Minoia
OBJECTIVES: To investigate clinical features associated with lack of response to MTX in juvenile idiopathic arthritis associated uveitis (JIA-U). METHODS: Clinical records of JIA-U patients were retrospectively reviewed. Differences among variables were assessed by Mann-Whitney and χ 2 or Fisher's exact tests as appropriate. Association between predictors and requirement of a biological disease modifying antirheumatic drug (bDMARD) was evaluated by univariate Cox regression analysis and Kaplan-Meier curves...
February 8, 2024: Rheumatology
#30
JOURNAL ARTICLE
Benjamin Suarez-Jimenez, Amit Lazarov, Xi Zhu, Sigal Zilcha-Mano, Yoojean Kim, Claire E Marino, Pavel Rjabtsenkov, Shreya Y Bavdekar, Daniel S Pine, Yair Bar-Haim, Christine L Larson, Ashley A Huggins, Terri deRoon-Cassini, Carissa Tomas, Jacklynn Fitzgerald, Mitzy Kennis, Tim Varkevisser, Elbert Geuze, Yann Quidé, Wissam El Hage, Xin Wang, Erin N O'Leary, Andrew S Cotton, Hong Xie, Chiahao Shih, Seth G Disner, Nicholas D Davenport, Scott R Sponheim, Saskia B J Koch, Jessie L Frijling, Laura Nawijn, Mirjam van Zuiden, Miranda Olff, Dick J Veltman, Evan M Gordon, Geoffery May, Steven M Nelson, Meilin Jia-Richards, Yuval Neria, Rajendra A Morey
BACKGROUND: Intrusive traumatic re-experiencing domain (ITRED) was recently introduced as a novel perspective on posttraumatic psychopathology, proposing to focus research of posttraumatic stress disorder (PTSD) on the unique symptoms of intrusive and involuntary re-experiencing of the trauma, namely, intrusive memories, nightmares, and flashbacks. The aim of the present study was to explore ITRED from a neural network connectivity perspective. METHODS: Data were collected from 9 sites taking part in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) PTSD Consortium ( n = 584) and included itemized PTSD symptom scores and resting-state functional connectivity (rsFC) data...
January 2024: Biol Psychiatry Glob Open Sci
#31
REVIEW
Marco Campetella, G B Filomena, F Marino, F Fantasia, P Russo, F Gavi, F Rossi, C Gandi, M Ragonese, N Foschi, A Totaro, E Sacco, M Racioppi, R Bientinesi
Urinary tract infections (UTIs) present a formidable challenge in the care of individuals affected by multiple sclerosis (MS). Lower urinary tract dysfunction is a prevalent issue among MS patients, predisposing them to an elevated risk of UTIs. When left untreated, UTIs can further exacerbate the already compromised quality of life in individuals with MS. The diagnosis and management of UTIs in MS patients necessitate a careful clinical evaluation. The objective of this review is to delineate preventive strategies and current and developing therapeutic approaches for preventing and treating UTIs associated with urinary dysfunction, catheterization, and upper urinary tract infections in patients with MS...
January 27, 2024: Urologia
#32
JOURNAL ARTICLE
Yijia Li, Manish C Choudhary, James Regan, Julie Boucau, Anusha Nathan, Tessa Speidel, May Yee Liew, Gregory E Edelstein, Yumeko Kawano, Rockib Uddin, Rinki Deo, Caitlin Marino, Matthew A Getz, Zahra Reynolds, Mamadou Barry, Rebecca F Gilbert, Dessie Tien, Shruti Sagar, Tammy D Vyas, James P Flynn, Sarah P Hammond, Lewis A Novack, Bina Choi, Manuela Cernadas, Zachary S Wallace, Jeffrey A Sparks, Jatin M Vyas, Michael S Seaman, Gaurav D Gaiha, Mark J Siedner, Amy K Barczak, Jacob E Lemieux, Jonathan Z Li
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the immune defects that predispose an individual to persistent coronavirus disease 2019 (COVID-19) remain incompletely understood. In this study, we performed detailed viro-immunologic analyses of a prospective cohort of participants with COVID-19. The median times to nasal viral RNA and culture clearance in individuals with severe immunosuppression due to hematologic malignancy or transplant (S-HT) were 72 and 40 days, respectively, both of which were significantly longer than clearance rates in individuals with severe immunosuppression due to autoimmunity or B cell deficiency (S-A), individuals with nonsevere immunodeficiency, and nonimmunocompromised groups ( P < 0...
January 24, 2024: Science Translational Medicine
#33
JOURNAL ARTICLE
Pierluigi Scalia, Ignazio R Marino, Salvatore Asero, Giuseppe Pandini, Adda Grimberg, Wafik S El-Deiry, Stephen J Williams
The paraneoplastic syndrome referred in the literature as non-islet-cell tumor hypoglycemia (NICTH) and extra-pancreatic tumor hypoglycemia (EPTH) was first reported almost a century ago, and the role of cancer-secreted IGF-II in causing this blood glucose-lowering condition has been widely established. The landscape emerging in the last few decades, based on molecular and cellular findings, supports a broader role for IGF-II in cancer biology beyond its involvement in the paraneoplastic syndrome. In particular, a few key findings are constantly observed during tumorigenesis, (a) a relative and absolute increase in fetal insulin receptor isoform (IRA ) content, with (b) an increase in IGF-II high-molecular weight cancer-variants (big-IGF-II), and (c) a stage-progressive increase in the IGF-II autocrine signal in the cancer cell, mostly during the transition from benign to malignant growth...
December 22, 2023: Biomedicines
#34
RANDOMIZED CONTROLLED TRIAL
Monique B Does, Sara R Adams, Andrea H Kline-Simon, Catherine Marino, Nancy Charvat-Aguilar, Constance M Weisner, Andrea L Rubinstein, Murtuza Ghadiali, Penney Cowan, Kelly C Young-Wolff, Cynthia I Campbell
BACKGROUND: Given significant risks associated with long-term prescription opioid use, there is a need for non-pharmacological interventions for treating chronic pain. Activating patients to manage chronic pain has the potential to improve health outcomes. The ACTIVATE study was designed to evaluate the effectiveness of a 4-session patient activation intervention in primary care for patients on long-term opioid therapy. METHODS: The two-arm, pragmatic, randomized trial was conducted in two primary care clinics in an integrated health system from June 2015-August 2018...
January 22, 2024: BMC Health Services Research
#35
REVIEW
Lei Wang, Mohsin Tanveer, Hongling Wang, Marino B Arnao
Seed germination (SG) is the first stage in a plant's life and has an immense importance in sustaining crop production. Abiotic stresses reduce SG by increasing the deterioration of seed quality, and reducing germination potential, and seed vigor. Thus, to achieve a sustainable level of crop yield, it is important to improve SG under abiotic stress conditions. Melatonin (MEL) is an important biomolecule that interplays in developmental processes and regulates many adaptive responses in plants, especially under abiotic stresses...
January 2024: Journal of Pineal Research
#36
JOURNAL ARTICLE
María Alejandra Garza-Ledezma, Sofía Mariño-Velasco, Mariana García-Leal, Joel Omar Jáquez-Quintana, Héctor Jesús Maldonado-Garza
This case report describes an 81-year-old male with Child-Pugh B chronic liver disease presenting with dyspnea and atypical precordial pain. Evaluation revealed a third-degree atrioventricular block, necessitating temporary pacemaker placement. Portable cardiac ultrasound identified an intracavitary mass in the right atrium. A triphasic abdominal CT scan unveiled a solid lesion in hepatic segments VII and VIII, displaying arterial phase enhancement and late-phase washout. The neoplastic lesion, measuring 9...
January 18, 2024: Revista Española de Enfermedades Digestivas
#37
JOURNAL ARTICLE
Simone Schiaffino, Andrea Cozzi, Paola Clauser, Elisabetta Giannotti, Maria Adele Marino, Thiemo J A van Nijnatten, Pascal A T Baltzer, Marc B I Lobbes, Ritse M Mann, Katja Pinker, Michael H Fuchsjäger, Ruud M Pijnappel
OBJECTIVES: To perform a survey among members of the European Society of Breast Imaging (EUSOBI) regarding the use of contrast-enhanced mammography (CEM). METHODS: A panel of nine board-certified radiologists developed a 29-item online questionnaire, distributed to all EUSOBI members (inside and outside Europe) from January 25 to March 10, 2023. CEM implementation, examination protocols, reporting strategies, and current and future CEM indications were investigated...
January 16, 2024: European Radiology
#38
JOURNAL ARTICLE
Shuqing Si, Anbreen Bi, Zhaoying Yu, Cheryl See, Sinead Kelly, Sonia Ambrogi, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Michael Berk, Josefina Castro-Fornieles, Benedicto Crespo-Facorro, Jacob J Crouse, Covadonga M Díaz-Caneja, Anne-Kathrin Fett, Adriana Fortea, Sophia Frangou, Benjamin I Goldstein, Ian B Hickie, Joost Janssen, Kody G Kennedy, Lydia Krabbendam, Marinos Kyriakopoulos, Bradley J MacIntosh, Pedro Morgado, Stener Nerland, Saül Pascual-Diaz, Maria Picó-Pérez, Fabrizio Piras, Bjørn Rishovd Rund, Elena de la Serna, Gianfranco Spalletta, Gisela Sugranyes, Chao Suo, Diana Tordesillas-Gutiérrez, Daniela Vecchio, Joaquim Radua, Philip McGuire, Sophia I Thomopoulos, Neda Jahanshad, Paul M Thompson, Claudia Barth, Ingrid Agartz, Anthony James, Matthew J Kempton
INTRODUCTION: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sample of individuals with EOP, using the newly developed ENIGMA-VBM tool. METHODS: 15 independent cohorts from the ENIGMA-EOP working group participated in the study...
January 10, 2024: Molecular Psychiatry
#39
John K Mich, Jiyun Ryu, Aguan D Wei, Bryan B Gore, Rong Guo, Angela M Bard, Refugio A Martinez, Yemeserach Bishaw, Em Luber, Luiz M Oliveira Santos, Nicole Miranda, Jan-Marino Ramirez, Jonathan T Ting, Ed S Lein, Boaz P Levi, Franck K Kalume
Dravet syndrome (DS) is a devastating developmental epileptic encephalopathy marked by treatment-resistant seizures, developmental delay, intellectual disability, motor deficits, and a 10-20% rate of premature death. Most DS patients harbor loss-of-function mutations in one copy of SCN1A , which has been associated with inhibitory neuron dysfunction. Here we developed an interneuron-targeting AAV human SCN1A gene replacement therapy using cell class-specific enhancers. We generated a split-intein fusion form of SCN1A to circumvent AAV packaging limitations and deliver SCN1A via a dual vector approach using cell class-specific enhancers...
December 15, 2023: bioRxiv
#40
JOURNAL ARTICLE
A J Marín-Peña, I Vega-Mas, I Busturia, C de la Osa, M B González-Moro, J A Monreal, D Marino
Phosphoenolpyruvate carboxylase (PEPC; EC 4.1.1.31) is an enzyme family with pivotal roles in plant carbon and nitrogen metabolism. A main role for non-photosynthetic PEPC is as anaplerotic enzyme to load tricarboxylic acid (TCA) cycle with carbon skeletons that compensate the intermediates diverted for biomolecule synthesis such as amino acids. When plants are grown under ammonium (NH4 + ) nutrition, the excessive uptake of NH4 + often provokes a stress situation. When plants face NH4 + stress, N assimilation is greatly induced and thus, requires the supply of carbon skeletons coming from TCA cycle...
December 25, 2023: Plant Physiology and Biochemistry: PPB
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