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Ryan Olson, Sharon V Thompson, Diane L Elliot, Jennifer A Hess, Kristy Luther Rhoten, Kelsey N Parker, Robert R Wright, Brad Wipfli, Katrina M Bettencourt, Annie Buckmaster, Miguel Marino
OBJECTIVES: To determine the effectiveness of the COMmunity of Practice And Safety Support (COMPASS) Total Worker Health intervention for home care workers. METHODS: We randomized 16 clusters of workers (n = 149) to intervention or usual-practice control conditions. The 12-month intervention was scripted and peer-led, and involved education on safety, health, and well-being; goal setting and self-monitoring; and structured social support. We collected measures at baseline, 6 months, and 12 months, which included workers' experienced community of practice (i...
October 2016: American Journal of Public Health
Keith I Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, A R M Ruhul Amin, Amr Amin, Katia Aquilano, Jack Arbiser, Alexandra Arreola, Alla Arzumanyan, S Salman Ashraf, Asfar S Azmi, Fabian Benencia, Dipita Bhakta, Alan Bilsland, Anupam Bishayee, Stacy W Blain, Penny B Block, Chandra S Boosani, Thomas E Carey, Amancio Carnero, Marianeve Carotenuto, Stephanie C Casey, Mrinmay Chakrabarti, Rupesh Chaturvedi, Georgia Zhuo Chen, Helen Chen, Sophie Chen, Yi Charlie Chen, Beom K Choi, Maria Rosa Ciriolo, Helen M Coley, Andrew R Collins, Marisa Connell, Sarah Crawford, Colleen S Curran, Charlotta Dabrosin, Giovanna Damia, Santanu Dasgupta, Ralph J DeBerardinis, William K Decker, Punita Dhawan, Anna Mae E Diehl, Jin-Tang Dong, Q Ping Dou, Janice E Drew, Eyad Elkord, Bassel El-Rayes, Mark A Feitelson, Dean W Felsher, Lynnette R Ferguson, Carmela Fimognari, Gary L Firestone, Christian Frezza, Hiromasa Fujii, Mark M Fuster, Daniele Generali, Alexandros G Georgakilas, Frank Gieseler, Michael Gilbertson, Michelle F Green, Brendan Grue, Gunjan Guha, Dorota Halicka, William G Helferich, Petr Heneberg, Patricia Hentosh, Matthew D Hirschey, Lorne J Hofseth, Randall F Holcombe, Kanya Honoki, Hsue-Yin Hsu, Gloria S Huang, Lasse D Jensen, Wen G Jiang, Lee W Jones, Phillip A Karpowicz, W Nicol Keith, Sid P Kerkar, Gazala N Khan, Mahin Khatami, Young H Ko, Omer Kucuk, Rob J Kulathinal, Nagi B Kumar, Byoung S Kwon, Anne Le, Michael A Lea, Ho-Young Lee, Terry Lichtor, Liang-Tzung Lin, Jason W Locasale, Bal L Lokeshwar, Valter D Longo, Costas A Lyssiotis, Karen L MacKenzie, Meenakshi Malhotra, Maria Marino, Maria L Martinez-Chantar, Ander Matheu, Christopher Maxwell, Eoin McDonnell, Alan K Meeker, Mahya Mehrmohamadi, Kapil Mehta, Gregory A Michelotti, Ramzi M Mohammad, Sulma I Mohammed, D James Morre, Vinayak Muralidhar, Irfana Muqbil, Michael P Murphy, Ganji Purnachandra Nagaraju, Rita Nahta, Elena Niccolai, Somaira Nowsheen, Carolina Panis, Francesco Pantano, Virginia R Parslow, Graham Pawelec, Peter L Pedersen, Brad Poore, Deepak Poudyal, Satya Prakash, Mark Prince, Lizzia Raffaghello, Jeffrey C Rathmell, W Kimryn Rathmell, Swapan K Ray, Jörg Reichrath, Sarallah Rezazadeh, Domenico Ribatti, Luigi Ricciardiello, R Brooks Robey, Francis Rodier, H P Vasantha Rupasinghe, Gian Luigi Russo, Elizabeth P Ryan, Abbas K Samadi, Isidro Sanchez-Garcia, Andrew J Sanders, Daniele Santini, Malancha Sarkar, Tetsuro Sasada, Neeraj K Saxena, Rodney E Shackelford, H M C Shantha Kumara, Dipali Sharma, Dong M Shin, David Sidransky, Markus David Siegelin, Emanuela Signori, Neetu Singh, Sharanya Sivanand, Daniel Sliva, Carl Smythe, Carmela Spagnuolo, Diana M Stafforini, John Stagg, Pochi R Subbarayan, Tabetha Sundin, Wamidh H Talib, Sarah K Thompson, Phuoc T Tran, Hendrik Ungefroren, Matthew G Vander Heiden, Vasundara Venkateswaran, Dass S Vinay, Panagiotis J Vlachostergios, Zongwei Wang, Kathryn E Wellen, Richard L Whelan, Eddy S Yang, Huanjie Yang, Xujuan Yang, Paul Yaswen, Clement Yedjou, Xin Yin, Jiyue Zhu, Massimo Zollo
Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted)...
December 2015: Seminars in Cancer Biology
Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David Jp Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin
Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained amino acid motif that has similarity to the PEXEL-motif of Plasmodium parasites. We show that ASP5 matures substrates at both the N- and C-terminal ends of proteins and also controls trafficking of effectors without this motif. Furthermore, ASP5 controls establishment of the nanotubular network and is required for the efficient recruitment of host mitochondria to the vacuole...
2015: ELife
Jessica Marino, Donald Bucher, Michael Beach, Balaji Yegneswaran, Brad Cooper
BACKGROUND: Delirium is a commonly observed problem for adult patients in the intensive care unit (ICU) that is associated with increased mortality, increased hospital length of stay, and long-term disability of ICU survivors. This makes prevention and prompt treatment of delirium imperative goals for critical-care providers. Bedside critical-care nurses are uniquely poised to champion efforts to prevent, detect, and treat delirium but oftentimes are not aware of the most recent evidence-based guidelines or the potential long-term implications for the ICU survivor...
September 2015: Dimensions of Critical Care Nursing: DCCN
Gila Perk, Roberto M Lang, Miguel Angel Garcia-Fernandez, Joe Lodato, Lissa Sugeng, John Lopez, Brad P Knight, David Messika-Zeitoun, Sanjiv Shah, James Slater, Eric Brochet, Mathew Varkey, Ziyad Hijazi, Nino Marino, Carlos Ruiz, Itzhak Kronzon
BACKGROUND: Real-time three-dimensional (RT3D) echocardiography is a recently developed technique that is being increasingly used in echocardiography laboratories. Over the past several years, improvements in transducer technologies have allowed development of a full matrix-array transducer that allows acquisition of pyramidal-shaped data sets. These data sets can be processed online and offline to allow accurate evaluation of cardiac structures, volumes, and mass. More recently, a transesophageal transducer with RT3D capabilities has been developed...
August 2009: Journal of the American Society of Echocardiography
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