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George hoffman

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https://www.readbyqxmd.com/read/28044005/biomechanical-ct-metrics-are-associated-with-patient-outcomes-in-copd
#1
Sandeep Bodduluri, Surya P Bhatt, Eric A Hoffman, John D Newell, Carlos H Martinez, Mark T Dransfield, Meilan K Han, Joseph M Reinhardt
BACKGROUND: Traditional metrics of lung disease such as those derived from spirometry and static single-volume CT images are used to explain respiratory morbidity in patients with COPD, but are insufficient. We hypothesised that the mean Jacobian determinant, a measure of local lung expansion and contraction with respiration, would contribute independently to clinically relevant functional outcomes. METHODS: We applied image registration techniques to paired inspiratory-expiratory CT scans and derived the Jacobian determinant of the deformation field between the two lung volumes to map local volume change with respiration...
January 2, 2017: Thorax
https://www.readbyqxmd.com/read/28017317/a-validation-study-of-the-automated-self-administered-24-hour-dietary-recall-for%C3%A2-children-2014-version-at-school-lunch
#2
Caroline F Krehbiel, George J DuPaul, Jessica A Hoffman
BACKGROUND: Obtaining valid and reliable estimates of usual dietary intake at a reasonable cost is a challenge in school-based nutrition research. The Automated Self-Administered 24-Hour Dietary Recall for Children, 2014 version (ASA24 Kids-2014), a self-administered, computerized 24-hour dietary recall, offers improved feasibility over traditional interviewer-administered 24-hour recalls. OBJECTIVE: This mixed-methods study examined ASA24 Kids-2014's validity for measuring dietary intake from National School Lunch Program lunches...
December 21, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28012642/postoperative-cerebral-and-somatic-near-infrared-spectroscopy-saturations-and-outcome-in-hypoplastic-left-heart-syndrome
#3
George M Hoffman, Nancy S Ghanayem, John P Scott, James S Tweddell, Michael E Mitchell, Kathleen A Mussato
BACKGROUND: Circulatory vulnerability reflected by low systemic venous oxygen saturation after surgical palliation of hypoplastic left heart syndrome predicts adverse neurologic outcome and reduced survival, and targeting venous saturation may improve outcome. We herein test the hypothesis that near-infrared spectroscopy (NIRS)-derived cerebral and somatic/renal regional saturations can predict survival. METHODS: Patient data, from a prospective Institutional Review Board-approved registry of hemodynamic measures after initial palliation of hypoplastic left heart syndrome, were analyzed with logistic and multivariable mixed regression methods to determine relationships between standard hemodynamic measures, direct and NIRS measures of saturation, and outcome...
December 21, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28001101/palatal-fistula-risk-after-primary-palatoplasty-a-retrospective-comparison-of-a-humanitarian-organization-and-tertiary-hospitals
#4
Kimberly M Daniels, Emily Yang Yu, Rebecca G Maine, Yin Heng, Li Yang, Bing Shi, D Scott Corlew, William Y Hoffman, George A Gregory
BACKGROUND:   Humanitarian surgical organizations provide palatoplasties for patients without access to surgical care. Few organizations have evaluated the outcomes of these trips. This study evaluates the palatal fistula rate in patients from two cohorts in rural China and one in the United States. METHODS:   This study compared the odds of fistula formation among three cohorts whose palates were repaired between 2005 and 2009. One cohort included 97 Chinese patients operated on by teams from the United States and Canada under the auspices of Resurge International...
December 21, 2016: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/27903260/clinical-physiologic-and-radiographic-factors-contributing-to-development-of-hypoxemia-in-moderate-to-severe-copd-a-cohort-study
#5
J Michael Wells, Raul San Jose Estepar, Merry-Lynn N McDonald, Surya P Bhatt, Alejandro A Diaz, William C Bailey, Francine L Jacobson, Mark T Dransfield, George R Washko, Barry J Make, Richard Casaburi, Edwin J R van Beek, Eric A Hoffman, Frank C Sciurba, James D Crapo, Edwin K Silverman, Craig P Hersh
BACKGROUND: Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little is known about characteristics that predict onset of resting hypoxemia in patients who are normoxic at baseline. We hypothesized that a combination of clinical, physiologic, and radiographic characteristics would predict development of resting hypoxemia after 5-years of follow-up in participants with moderate to severe COPD METHODS: We analyzed 678 participants with moderate-to-severe COPD recruited into the COPDGene cohort who completed baseline and 5-year follow-up visits and who were normoxic by pulse oximetry at baseline...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27856674/longitudinal-evaluation-of-language-impairment-in-youth-with-perinatally-acquired-human-immunodeficiency-virus-hiv-and-youth-with-perinatal-hiv-exposure
#6
Sean M Redmond, Tzy-Jyun Yao, Jonathan S Russell, Mabel L Rice, Howard J Hoffman, George K Siberry, Toni Frederick, Murli Purswani, Paige L Williams
BACKGROUND: Language impairment (LI) risk is increased for perinatally acquired human immunodeficiency virus-infected (PHIV) and perinatally exposed to HIV but uninfected (PHEU) youth. This study evaluates the persistence of LI in these groups. METHODS: The Clinical Evaluation of Language Fundamentals was repeated on participants of the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol 18 months postbaseline. Regression models identified factors associated with change in standardized score (SC) and the resolution or development of LI...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27780004/effects-of-daytime-exposure-to-light-from-blue-enriched-light-emitting-diodes-on-the-nighttime-melatonin-amplitude-and-circadian-regulation-of-rodent-metabolism-and-physiology
#7
Robert T Dauchy, Melissa A Wren-Dail, Aaron E Hoffman, John P Hanifin, Benjamin Warfield, George C Brainard, Steven M Hill, Victoria P Belancio, Erin M Dauchy, David E Blask
Regular cycles of exposure to light and dark control pineal melatonin production and temporally coordinate circadian rhythms of metabolism and physiology in mammals. Previously we demonstrated that the peak circadian amplitude of nocturnal blood melatonin levels of rats were more than 6-fold higher after exposure to cool white fluorescent (CWF) light through blue-tinted (compared with clear) rodent cages. Here, we evaluated the effects of light-phase exposure of rats to white light-emitting diodes (LED), which emit light rich in the blue-appearing portion of the visible spectrum (465-485 nm), compared with standard broadspectrum CWF light, on melatonin levels during the subsequent dark phase and on plasma measures of metabolism and physiology...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27696640/assessing-the-multiscale-architecture-of-muscular-tissue-with-q-space-magnetic-resonance-imaging-review
#8
Matthew P Hoffman, Erik N Taylor, George E Aninwene, Sakthivel Sadayappan, Richard J Gilbert
Contraction of muscular tissue requires the synchronized shortening of myofibers arrayed in complex geometrical patterns. Imaging such myofiber patterns with diffusion-weighted MRI reveals architectural ensembles that underlie force generation at the organ scale. Restricted proton diffusion is a stochastic process resulting from random translational motion that may be used to probe the directionality of myofibers in whole tissue. During diffusion-weighted MRI, magnetic field gradients are applied to determine the directional dependence of proton diffusion through the analysis of a diffusional probability distribution function (PDF)...
October 2, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27651048/protected-resident-research-time-does-not-increase-the-quantity-or-quality-of-residency-program-research-publications-a-comparison-of-3-orthopedic-residencies
#9
Chad A Krueger, Jeffery D Hoffman, George C Balazs, Anthony E Johnson, Benjamin K Potter, Philip J Belmont
INTRODUCTION: The effect of dedicated resident research time in terms of residency program research productivity remains largely unknown. We hypothesize that the quantity and quality of a residency program's peer-reviewed publications (PRPs) increase proportionately with the amount of dedicated research time given to residents. METHODS: Three residency programs (P1, P2, and P3) were examined. P1 has a mandatory research year for all residents between postgraduate years 3 and 4...
September 16, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27500932/racial-ethnic-disparities-in-measures-of-self-reported-psychosocial-states-and-traits-during-pregnancy
#10
William A Grobman, Corette Parker, Pathik D Wadhwa, Marian Willinger, Hyagriv Simhan, Bob Silver, Ron J Wapner, Samuel Parry, Brian Mercer, David Haas, Alan M Peaceman, Shannon Hunter, Deborah Wing, Steve Caritis, Sean Esplin, Matt Hoffman, Jack Ludmir, Jay Iams, Emily Long, George Saade, Uma M Reddy
Background The aim of this study was to determine whether racial/ethnic differences in psychosocial measures, independent of economic status, exist among a large population of pregnant nulliparas. Methods Between October 2010 and September 2013, nulliparous women at eight U.S. medical centers were followed longitudinally during pregnancy and completed validated instruments to quantify several psychosocial domains: Cohen Perceived Stress Scale, trait subscale of the Spielberger Anxiety Inventory, Connor-Davidson Resilience Scale, Multidimensional Scale of Perceived Social Support, Krieger Racism Scale, Edinburgh Postnatal Depression Scale, and the Pregnancy Experience Scale...
December 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27490600/near-infrared-spectroscopy-as-a-hemodynamic-monitor-in-critical-illness
#11
Nancy S Ghanayem, George M Hoffman
OBJECTIVES: The objectives of this review are to discuss the technology and clinical interpretation of near infrared spectroscopy oximetry and its clinical application in patients with congenital heart disease. DATA SOURCE: MEDLINE and PubMed. CONCLUSION: Near infrared spectroscopy provides a continuous noninvasive assessment of tissue oxygenation. Over 20 years ago, near infrared spectroscopy was introduced into clinical practice for monitoring cerebral oxygenation during cardiopulmonary bypass in adults...
August 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27373587/alterations-in-cardiac-mechanics-following-ultra-endurance-exercise-insights-from-left-and-right-ventricular-area-deformation-loops
#12
Rachel Lord, Keith George, John Somauroo, Mike Stembridge, Nikhil Jain, Martin D Hoffman, Rob Shave, Francois Haddad, Euan Ashley, Helen Jones, David Oxborough
BACKGROUND: The aim of this study was to use novel area-deformation (ε) loops to interrogate the interaction between the right ventricular (RV) and left ventricular (LV) mechanics following a 100-mile endurance run. METHODS: Fifteen participants (mean body mass, 70.1 ± 8.8 kg; mean age, 40 ± 8 years) were recruited for the study. Echocardiography was performed before the race, after the race, and 6 hours into recovery. RV and LV area and longitudinal ε were assessed using standard and speckle-tracking echocardiography...
September 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27293068/functional-characterization-of-two-novel-germline-mutations-of-the-kcnj5-gene-in-hypertensive-patients-without-primary-aldosteronism-but-with-acth-dependent-aldosterone-hypersecretion
#13
Amalia Sertedaki, Athina Markou, Dimitrios Vlachakis, Sophia Kossida, Emilie Campanac, Dax A Hoffman, Maria De La Luz Sierra, Paraskevi Xekouki, Constantine A Stratakis, Gregory Kaltsas, George P Piaditis, George P Chrousos, Evangelia Charmandari
BACKGROUND: Germline mutations of the KCNJ5 gene encoding Kir3·4, a member of the inwardly rectifying K(+) channel, have been identified in 'normal' adrenal glands, patients with familial hyperaldosteronism (FH) type III, aldosterone-producing adenomas (APAs) and sporadic cases of primary aldosteronism (PA). OBJECTIVE: To present two novel KCNJ5 gene mutations in hypertensive patients without PA, but with Adrenocorticotropic hormone (ACTH)-dependent aldosterone hypersecretion...
December 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27292566/morbidity-and-mortality-of-radical-nephrectomy-for-patients-with-disseminated-cancer-an-analysis-of-the-national-surgical-quality-improvement-program-database
#14
Christopher J D Wallis, Georg Bjarnason, James Byrne, Douglas C Cheung, Azik Hoffman, Girish S Kulkarni, Avery B Nathens, Robert K Nam, Raj Satkunasivam
OBJECTIVE: To determine the effect of disseminated cancer on perioperative outcomes following radical nephrectomy. METHODS: We conducted a retrospective cohort study of patients undergoing radical nephrectomy for kidney cancer from 2005 to 2014 using the American College of Surgeons National Surgical Quality Improvement Program, a multi-institutional prospective registry that captures perioperative surgical complications. Patients were stratified according to the presence (n = 657) or absence (n = 7143) of disseminated cancer at the time of surgery...
September 2016: Urology
https://www.readbyqxmd.com/read/27258177/management-of-a-patient-with-tetralogy-of-fallot-congenital-diaphragmatic-hernia-and-complete-left-lung-agenesis
#15
Kristen Labovsky, George Hoffman, John Scott
We describe the rare case of an infant with congenital diaphragmatic hernia, unilateral lung agenesis, and unpalliated single-ventricle physiology. Infants with congenital diaphragmatic hernia and parallel circulation are at risk for maldistribution of systemic and pulmonary blood flow. Optimal perioperative management should include an assessment of the ratio of pulmonary to systemic blood flow (Qp:Qs). Traditionally, arterial and systemic venous oxygen (SvO2) saturations are needed to calculate Qp:Qs. However, in this case, SvO2 measurement was not feasible...
July 1, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27257092/treatment-preferences-for-active-surveillance-versus-active-treatment-among-men-with-low-risk-prostate-cancer
#16
Kathryn L Taylor, Richard M Hoffman, Kimberly M Davis, George Luta, Amethyst Leimpeter, Tania Lobo, Scott P Kelly, Jun Shan, David Aaronson, Catherine A Tomko, Amy J Starosta, Charlotte J Hagerman, Stephen K Van Den Eeden
BACKGROUND: Due to the concerns about the overtreatment of low-risk prostate cancer, active surveillance (AS) is now a recommended alternative to the active treatments (AT) of surgery and radiotherapy. However, AS is not widely utilized, partially due to psychological and decision-making factors associated with treatment preferences. METHODS: In a longitudinal cohort study, we conducted pretreatment telephone interviews (N = 1,140, 69.3% participation) with newly diagnosed, low-risk prostate cancer patients (PSA ≤ 10, Gleason ≤ 6) from Kaiser Permanente Northern California...
August 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27091570/sociodemographic-and-clinical-predictors-of-switching-to-active-treatment-among-a-large-ethnically-diverse-cohort-of-men-with-low-risk-prostate-cancer-on-observational-management
#17
Scott P Kelly, Stephen K Van Den Eeden, Richard M Hoffman, David S Aaronson, Tania Lobo, George Luta, Amethyst D Leimpter, Jun Shan, Arnold L Potosky, Kathryn L Taylor
PURPOSE: We determined the clinical and sociodemographic predictors of beginning active treatment in an ethnically diverse population of men with low risk prostate cancer initially on observational treatment. MATERIALS AND METHODS: We retrospectively studied men diagnosed with low risk prostate cancer between 2004 and 2012 at Kaiser Permanente Northern California who did not receive any treatment within the first year of diagnosis and had at least 2 years of followup...
September 2016: Journal of Urology
https://www.readbyqxmd.com/read/27068630/alterations-in-multi-scale-cardiac-architecture-in-association-with-phosphorylation-of-myosin-binding-protein-c
#18
Erik N Taylor, Matthew P Hoffman, David Y Barefield, George E Aninwene, Aurash D Abrishamchi, Thomas L Lynch, Suresh Govindan, Hanna Osinska, Jeffrey Robbins, Sakthivel Sadayappan, Richard J Gilbert
BACKGROUND: The geometric organization of myocytes in the ventricular wall comprises the structural underpinnings of cardiac mechanical function. Cardiac myosin binding protein-C (MYBPC3) is a sarcomeric protein, for which phosphorylation modulates myofilament binding, sarcomere morphology, and myocyte alignment in the ventricular wall. To elucidate the mechanisms by which MYBPC3 phospho-regulation affects cardiac tissue organization, we studied ventricular myoarchitecture using generalized Q-space imaging (GQI)...
March 15, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27027796/exploratory-insights-from-the-right-sided-electrocardiogram-following-prolonged-endurance-exercise
#19
Rachel Lord, Keith George, John Somauroo, Nikhil Jain, Kristin Reese, Martin D Hoffman, Francois Haddad, Euan Ashley, Helen Jones, David Oxborough
BACKGROUND: Prolonged strenuous exercise has a profound effect on cardiac function. The right heart may be more susceptible to this imposition; yet, right-sided chest leads have not been utilised in this setting. METHODS: Thirty highly trained athletes at the 2014 Western States 100-mile Endurance Run from Squaw Valley to Auburn, California (body mass 68 ± 12 kg, age 45 ± 10 years, 57 ± 15 miles per week) were recruited for the study. Pre- and post-race, a right-sided 12-lead ECG was obtained and data were extracted for P, R and S waves, J point, ST segment and T wave amplitude...
November 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/26959201/ultrasound-measurement-of-the-fetal-adrenal-gland-as-a-predictor-of-spontaneous-preterm-birth
#20
MULTICENTER STUDY
Matthew K Hoffman, Ozhan M Turan, Corette B Parker, Ronald J Wapner, Deborah A Wing, David M Haas, M Sean Esplin, Samuel Parry, William A Grobman, Hyagriv N Simhan, Stephen Myers, Tommy E Holder, Pamela Rumney, Christian G Litton, Robert M Silver, Michal A Elovitz, Alan M Peaceman, Stephen Emery, Brian M Mercer, Matthew A Koch, George R Saade
OBJECTIVE: To estimate whether ultrasound measurement of the fetal adrenal gland remote from delivery in asymptomatic women can accurately predict spontaneous preterm birth. METHODS: We conducted a prospective multicenter observational nested cohort study of asymptomatic nulliparous women with a singleton pregnancy to study adverse pregnancy outcomes. Between 22 0/7 and 30 6/7 weeks of gestation, credentialed ultrasonographers measured the width (width), length (length), and, when able, depth (depth) of the "fetal zone" of the fetal adrenal gland as well as the width (Width), length (Length), and depth (Depth) of the total gland...
April 2016: Obstetrics and Gynecology
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