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Sex dysfunction in treated breast cancer

Woo-Baek Chung, Ho-Joong Youn
Cardiotoxicity is a well-known complication following treatment with anthracyclines. However, they are still widely used in chemotherapy for breast cancer, lymphoma, leukemia, and sarcoma, among others. Patient clinical characteristics, such as age, sex, comorbidities, anthracycline dose and infusion schedule, and the combined anti-cancer agents used, are diverse among cancer types. It is difficult to recommend guidelines for the prevention or management of anthracycline-induced cardiotoxicity applicable to all cancer types...
July 2016: Korean Journal of Internal Medicine
Susanna B Hummel, Jacques J D M van Lankveld, Hester S A Oldenburg, Daniela E E Hahn, Eva Broomans, Neil K Aaronson
BACKGROUND: Sexual dysfunction is a prevalent, long-term complication of breast cancer and its treatment and can be treated effectively with face-to-face sexual counselling. However, relatively few women actually opt for face-to-face sex therapy, with many women indicating that it is too confronting. Internet-based interventions might be a less threatening and more acceptable approach, because of the convenience, accessibility and privacy it provides. Recent studies have demonstrated the efficacy of internet-based programs for improving sexual functioning in the general population...
April 28, 2015: BMC Cancer
Melissa Dahir, Dianne Travers-Gustafson
INTRODUCTION: Women with breast cancer have better cancer-related outcomes with the use of aromatase inhibitors (AIs), but the physiological suppression of estradiol can negatively affect sexual functioning because of unpleasant urogenital and vaginal symptoms. Local health care practitioners have observed that the benefits of vaginal testosterone in allaying these unpleasant symptoms in women with breast cancer are similar to the benefits of vaginal estrogen in women without breast cancer...
April 2014: Sexual Medicine
Michel G Khouri, Whitney E Hornsby, Niels Risum, Eric J Velazquez, Samantha Thomas, Amy Lane, Jessica M Scott, Graeme J Koelwyn, James E Herndon, John R Mackey, Pamela S Douglas, Lee W Jones
Conventional resting left ventricular ejection fraction (LVEF) assessments have limitations for detecting doxorubicin (DOX)-related cardiac dysfunction. Novel resting echocardiographic parameters, including 3-dimensional echocardiography (3DE) and global longitudinal strain (GLS), have potential for early identification of chemotherapy-related myocardial injury. Exercise "stress" is an established method to uncover impairments in cardiac function but has received limited attention in the adult oncology setting...
February 2014: Breast Cancer Research and Treatment
F Orio, G Muscogiuri, A Ascione, F Marciano, A Volpe, G La Sala, S Savastano, A Colao, S Palomba
The excess in physical activity could be closely linked to considerable negative consequences on the whole body. These dysfunctions called as "female athlete triad"' by the American College of Sports Medicine (ACSM) include amenorrhea, osteoporosis and disorder eating. The female athlete triad poses serious health risks, both on the short and on the long term, to the overall well-being of affected individuals. Sustained low energy availability can impair health, causing many medical complications within skeletal, endocrine, cardiovascular, reproductive and central nervous system...
September 2013: Minerva Endocrinologica
Sonia Zaied, Leila Ben Fatma, Amel Laadhari, Mohamed Zaher Boudegga, Makram Hochlef, Imène Chabchoub, Feten Ezzairi, Olfa Gharbi, Lotfi Gaha, Slim Ben Ahmed
The prognosis of breast cancer has significantly improved during the last years due to progress of the treatment options. It is a public health problem because of its frequency, severity, physical and psychological consequences. Quality of life appears increasingly as fundamental criteria in the assessment of treatment outcomes. This underlines the specific impact on sexuality. Aim. To evaluate the frequency and type of sexual dysfunction in 100 patients treated for non-metastatic breast cancer in post-treatment monitoring in external consultation of the Department of Oncological Medicine, CHU Farhat Hached, Sousse...
July 2013: Bulletin du Cancer
Tomoo Shiozawa, Jun-ichi Tadokoro, Toshitaka Fujiki, Koji Fujino, Koji Kakihata, Shuji Masatani, Satoshi Morita, Akihiko Gemma, Narikazu Boku
OBJECTIVES: This analysis was conducted to clarify risk factors for severe adverse effects and treatment-related deaths reported during a postmarketing survey of irinotecan. METHODS: The survey covered all patients treated with irinotecan in Japan between April 1995 and January 2000. The patient background data and adverse drug reactions were collected through case report forms. Univariate and multivariate logistic regression analyses including 14 explanatory variables were performed to determine the risk factors for grade 3-4 leukopenia, thrombocytopenia and diarrhea for all patients and subgroups with five major cancers...
May 2013: Japanese Journal of Clinical Oncology
Stefan Toggweiler, Yvonne Odermatt, Andreas Brauchlin, Thilo Zander, Andrea Müller, Michel Zuber, Ralph Winterhalder, Paul Erne
BACKGROUND: Investigate the usefulness of echocardiography and acoustic cardiography to monitor patients exposed to anthracycline chemotherapy. HYPOTHESIS: Serial echocardiographies to monitor systolic function may not be neccessary in all patients undergoing anthracycline chemotherapy. METHODS: In a prospective study, consecutive patients undergoing anthracycline-containing chemotherapy were evaluated with echocardiography and acoustic cardiography at baseline, after completion of chemotherapy, and after a median follow-up of 3...
April 2013: Clinical Cardiology
Juliane Baumgart, Kerstin Nilsson, Anneli Stavreus Evers, Theodora Kunovac Kallak, Inger Sundström Poromaa
OBJECTIVE: The goal of this study was to investigate sexual function in postmenopausal breast cancer patients treated with aromatase inhibitors. METHODS: A population-based, cross-sectional study was conducted among postmenopausal breast cancer patients on adjuvant endocrine treatment and age-matched controls with and without estrogen treatment. Sexual function was assessed with a standardized questionnaire. RESULTS: In all, 42.4% of aromatase inhibitor-treated breast cancer patients were dissatisfied with their sex life in general, and 50...
February 2013: Menopause: the Journal of the North American Menopause Society
Mohammad Reza Safarinejad, Nayyer Shafiei, Shiva Safarinejad
BACKGROUND: The breast cancer (BC) and its treatment (mastectomy, radiotherapy, and chemotherapy) have considerable psychosexual impacts on women's life. This study evaluated sexual functioning, quality of life, and self-esteem in young women with early-stage BC. METHODS: A total of 186 women with stage I or II BC and 204 age-matched controls aged 25-45 years were recruited. To be eligible, patients had to be disease-free and sexually active. They also had to have undergone lumpectomy at least 1 year previously and have completed chemotherapy and/or radiotherapy...
June 2013: Psycho-oncology
Jennifer Barsky Reese, Francis J Keefe, Tamara J Somers, Amy P Abernethy
INTRODUCTION: Although cancer treatment commonly has a negative impact on sexual functioning, sexual concerns are still largely undertreated in routine cancer care. The medical model that guides current approaches to sexual care in cancer does not adequately address key patient needs. METHODS: In this paper, we describe a broader approach to understanding and treating sexual concerns in cancer that focuses on the construct of flexibility in behavioral and cognitive coping strategies...
July 2010: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Xuenong Ouyang, Wenwu Wang, Yonghai Peng
OBJECTIVE: To investigate the factors related to sexual dysfunction among breast cancer patients so as to improve the prevention and treatment of the disorder as well as the life quality of the patients. METHODS: Sixty-five breast cancer patients during the rehabilitation period were interviewed by questionnaire on the sexual function before and after treatment. RESULTS: Age and perception of sex were two important factors for the significant difference in the rate of sexual dysfunction among the patients...
July 2004: Zhonghua Nan Ke Xue, National Journal of Andrology
Jae C Chang, Tahir Naqvi
To examine the relationship between cancer and development of thrombotic microangiopathy (TM), the medical records of patients with known TM were examined in one institution from January 1981 to December 2002. Nine out of 93 patients with the established diagnosis of TM had active cancer. All nine of those patients had thrombotic thrombocytopenic purpura (TTP). Among those patients, two patients received chemotherapy prior to the development of TTP. Six of the seven patients who received no chemotherapy had extensive bone marrow metastasis and secondary myelofibrosis...
2003: Oncologist
Jo A Broeckel, Christina L Thors, Paul B Jacobsen, Margaret Small, Charles E Cox
BACKGROUND: Previous reports suggest that problems in sexual functioning may be common among long-term (> 5 years) breast cancer survivors. To investigate this issue further, we examined the characteristics and correlates of sexual functioning in women diagnosed with breast cancer at least 5 years previously and treated with adjuvant chemotherapy and in an age-matched comparison group of women with no history of cancer. PATIENTS AND METHODS: Participants were 58 women initially diagnosed with breast cancer at an average of 7...
October 2002: Breast Cancer Research and Treatment
Cesare Bordi, Cinzia Azzoni, Tiziana D'Adda, Anna Bertele, Riccardo Volpi, Angelo Franze
A 48-year-old woman with Zollinger-Ellison syndrome (ZES), but no evidence of multiple endocrine neoplasia (MEN)-1 syndrome, developed an unusually florid evolution of enterochromaffin-like (ECL) cell hyperplasia, which led to extensive replacement of oxyntic glands by endocrine tissue and resulted in the disappearance of the patient's gastric acid hypersecretion with antisecretory treatment no longer required. The patient's previous history included breast cancer, treated with surgery and 5 years of antiestrogen therapy, and bilateral granulosathecal cell tumor of the ovary...
1995: Endocrine Pathology
Judith A Shell
PURPOSE/OBJECTIVES: To provide a systematic review in relation to evidence-based practice for the management of sexual dysfunction in adults with cancer and to define the current state of knowledge about intervention for this symptom, the gaps and barriers in the current state of knowledge, and recommendations for public education and future research direction. DATA SOURCES: Articles published from 1980-2000, books, and practice standards. DATA SYNTHESIS: Few tested interventions are available to treat sexual dysfunction in patients with cancer...
January 2002: Oncology Nursing Forum
L M Anllo
The trauma of being diagnosed and treated for breast cancer can impact greatly on womens' psychosexual functioning and intimate relationships. Survivors of breast cancer report that issues of body image, sexuality and partner communication rarely are addressed by traditional health care providers (Ganz, Rowland, Desmond, Meyerowitz, & Wyatt, 1998). Psychotherapy can help women cope with difficult changes in body image and sexual functioning, and there is evidence that psychotherapy may prolong life (Speigel, Bloom, Kraemer, & Gottheil, 1989)...
July 2000: Journal of Sex & Marital Therapy
J E Mortimer, L Boucher, J Baty, D L Knapp, E Ryan, J H Rowland
PURPOSE: To define the incidence of sexual dysfunction in a population of women with breast cancer treated with tamoxifen. PATIENTS AND METHODS: Breast cancer patients with a performance status of 0 to 2 who had been treated with tamoxifen for 2 to 24 months completed the following measures: the Center for Epidemiologic Studies-Depression Scale, the Sexual History Form, and the Breast Cancer Prevention Trial Symptom Checklist. Forty-nine of the participants underwent gynecologic examinations with vaginal smears for determination of estrogen effect...
May 1999: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
S Barni, R Mondin
BACKGROUND: This study examined the impact of breast cancer therapy on women's sexuality. PATIENTS AND METHODS: A questionnaire concerning various sexual problems experienced before and after treatment was anonymously completed by 50 women in the outpatient clinic of our hospital's Division of Radiation Oncology. To be eligible, subjects had to be disease-free and sexually active. They also had to have undergone surgery at least one year previously and have completed CT and or RT...
February 1997: Annals of Oncology: Official Journal of the European Society for Medical Oncology
F Bach, B H Larsen, K Rohde, S E Børgesen, F Gjerris, T Bøge-Rasmussen, N Agerlin, B Rasmusson, P Stjernholm, P S Sørensen
We reviewed all medical records concerning patients suffering from spinal cord or cauda equina compression (SCC) secondary to cancer, in the eastern part of Denmark, from 1979 through 1985. During the period the incidence of SCC in cancer patients went up from 4.4% to 6%. However, this increase was not significant. The series comprised 398 cases, with carcinoma of the prostate (19%), lung (18%), breast (14%) and kidney (10%) accounting for 61%. The symptoms were evaluated in accordance with the patients rating of pain, motor deficits, sphincter control and paraesthesia, whereas the clinical manifestations were classified on the basis of motor deficit and bladder dysfunction...
1990: Acta Neurochirurgica
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