Myrofora Panagi, Chrysovalantis Voutouri, Fotios Mpekris, Panagiotis Papageorgis, Margaret R Martin, John D Martin, Philippos Demetriou, Chryso Pierides, Christiana Polydorou, Andreas Stylianou, Maria Louca, Laura Koumas, Paul Costeas, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Tumor normalization strategies aim to improve tumor blood vessel functionality (i.e., perfusion) by reducing the hyper-permeability of tumor vessels or restoring compressed vessels. Despite progress in strategies to normalize the tumor microenvironment (TME), their combinatorial antitumor effects with nanomedicine and immunotherapy remain unexplored. Methods : Here, we re-purposed the TGF-β inhibitor tranilast, an approved anti-fibrotic and antihistamine drug, and combined it with Doxil nanomedicine to normalize the TME, increase perfusion and oxygenation, and enhance anti-tumor immunity...
2020: Theranostics