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Open MRS

Ling Gao, Weina Cui, Pengyuan Zhang, Albert Jang, Wuqiang Zhu, Jianyi Zhang
Utilizing a fast 31P magnetic resonance spectroscopy (MRS) 2-dimensional chemical shift imaging (2D-CSI) method, this study examined the heterogeneity of creatine kinase (CK) forward flux rate of hearts with postinfarction left ventricular (LV) remodeling. Immunosuppressed Yorkshire pigs were assigned to 4 groups: 1) A sham-operated normal group (SHAM, n = 6); 2) A 60 minutes distal left anterior descending coronary artery ligation and reperfusion (MI, n = 6); 3) Open patch group; ligation injury plus open fibrin patch over the site of injury (Patch, n = 6); and 4) Cell group, hiPSCs-cardiomyocytes, -endothelial cells, and -smooth muscle cells (2 million, each) were injected into the injured myocardium pass through a fibrin patch (Cell+Patch, n = 5)...
2016: PloS One
Mario Zanaty, Nohra Chalouhi, Robert M Starke, Badih Daou, Michael Todd, Emine Bayman, James Torner, David Hasan
OBJECTIVE: Studies that showed endovascular coiling of ruptured intracranial aneurysms (RAs) to be superior to microsurgical clipping were comparing dedicated endovascular interventionalists vs. open cerebrovascular surgeons. This is the first study to evaluate outcomes of coiling vs. clipping of RAs treated by a dual trained cerebrovascular surgeon using a specific intervention protocol. METHODS: The prospectively maintained database was reviewed for all patients with RAs undergoing endovascular coiling (+/- stenting) or clipping by the senior author (dual trained vascular neurosurgeon) between July 2010 and April 2015...
August 12, 2016: World Neurosurgery
Lala Ceklic, Marion R Munk, Ute Wolf-Schnurrbusch, Margarita Gekkieva, Sebastian Wolf
PURPOSE: To investigate visual and morphological outcome in eyes with MRS and choroidal neovascularization (CNV) secondary to pathologic myopia treated with intravitreal (IVT) ranibizumab. METHODS: Post hoc analysis of the patients included in the RADIANCE trial (n = 277) was performed to evaluate the impact of MRS on the functional outcome in patients with myopic choroidal neovascularization (mCNV) undergoing intravitreal ranibizumab injections. RESULTS: Prevalence of MRS in pathologic myopia population is 6%...
August 16, 2016: Retina
Franca Podo, Luisa Paris, Serena Cecchetti, Francesca Spadaro, Laura Abalsamo, Carlo Ramoni, Alessandro Ricci, Maria Elena Pisanu, Francesco Sardanelli, Rossella Canese, Egidio Iorio
Elucidation of molecular mechanisms underlying the aberrant phosphatidylcholine cycle in cancer cells plays in favor of the use of metabolic imaging in oncology and opens the way for designing new targeted therapies. The anomalous choline metabolic profile detected in cancer by magnetic resonance spectroscopy and spectroscopic imaging provides molecular signatures of tumor progression and response to therapy. The increased level of intracellular phosphocholine (PCho) typically detected in cancer cells is mainly attributed to upregulation of choline kinase, responsible for choline phosphorylation in the biosynthetic Kennedy pathway, but can also be partly produced by activation of phosphatidylcholine-specific phospholipase C (PC-PLC)...
2016: Frontiers in Oncology
Julien Valette, Brice Tiret, Fawzi Boumezbeur
In vivo carbon 13 ((13)C) MRS opens unique insights into the metabolism of intact organisms, and has led to major advancements in the understanding of cellular metabolism under normal and pathological conditions in various organs such as skeletal muscles, the heart, the liver and the brain. However, the technique comes at the expense of significant experimental difficulties. In this review we focus on the experimental aspects of non-hyperpolarized (13)C MRS in vivo. Some of the enrichment strategies which have been proposed so far are described; the various MRS acquisition paradigms to measure (13)C labeling are then presented...
August 8, 2016: Analytical Biochemistry
M Irem Baharoglu, Rustam Al-Shahi Salman, Charlotte Cordonnier, Rob J de Haan, Yvo B W E M Roos
BACKGROUND: Use of antiplatelet therapy shortly before stroke due to spontaneous primary intracerebral haemorrhage (ICH) is associated with higher case fatality in comparison to ICH without prior antithrombotic drug use. The PlAtelet Transfusion in Cerebral Haemorrhage (PATCH) trial aimed to assess the effect of platelet transfusion in patients presenting with ICH while using antiplatelet therapy. The main hypothesis of PATCH was that platelet transfusion would reduce death or dependence by reducing ICH growth...
2016: Trials
Robert J Brown, Brandon J Jun, Jesse D Cushman, Christine Nguyen, Adam H Beighley, Johnny Blanchard, Kei Iwamoto, Dorthe Schaue, Neil G Harris, James D Jentsch, Stefan Bluml, William H McBride
PURPOSE: In pediatric cancer survivors treated with whole-brain irradiation (WBI), long-term cognitive deficits and morbidity develop that are poorly understood and for which there is no treatment. We describe similar cognitive defects in juvenile WBI rats and correlate them with alterations in diffusion tensor imaging and magnetic resonance spectroscopy (MRS) during brain development. METHODS AND MATERIALS: Juvenile Fischer rats received clinically relevant fractionated doses of WBI or a high-dose exposure...
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Furong Guo, Cheng Chen, Kangcai Wang, Qinghua Zhang, Zhien Lin
A series of open-framework metal oxalates (metal = Zn, Co, Mn, Bi, In) were prepared under solvent-free conditions by a supramolecular templating approach. These compounds have cationic, anionic, and neutral frameworks with pore apertures ranging from small 8-membered rings (8 MRs) to extra-large 16 and 20 MRs. The zinc oxalate exhibits a proton conductivity of 2.6 × 10(-3) S cm(-1) at 60 °C under 98% relative humidity.
August 15, 2016: Inorganic Chemistry
Olvert A Berkhemer, Lucie A van den Berg, Puck S S Fransen, Debbie Beumer, Albert J Yoo, Hester F Lingsma, Wouter J Schonewille, René van den Berg, Marieke J H Wermer, Jelis Boiten, Geert J Lycklama À Nijeholt, Paul J Nederkoorn, Markus W Hollmann, Wim H van Zwam, Aad van der Lugt, Robert J van Oostenbrugge, Charles B L M Majoie, Diederik W J Dippel, Yvo B W E M Roos
BACKGROUND: The aim of the current study was to assess the influence of anesthetic management on the effect of treatment in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN). METHODS: MR CLEAN was a multicenter, randomized, open-label trial of intra-arterial therapy (IAT) vs no IAT. The intended anesthetic management at the start of the procedure was used for this post hoc analysis. The primary effect parameter was the adjusted common odds ratio (acOR) for a shift in direction of a better outcome on the modified Rankin Scale (mRS) at 90 days, estimated with multivariable ordinal logistic regression analysis, which included a term for general anesthesia (GA)...
August 16, 2016: Neurology
Kimberley J Mathot, Robin N Abbey-Lee, Bart Kempenaers, Niels J Dingemanse
Several studies have shown that individuals with higher metabolic rates (MRs) feed at higher rates and are more willing to forage in the presence of predators. This increases the acquisition of resources, which in turn, may help to sustain a higher MR. Elevated predation danger may be expected to result in reduced MRs, either as a means of allowing for reduced feeding and risk-taking, or as a consequence of adaptively reducing intake rates via reduced feeding and/or risk-taking. We tested this prediction in free-living great tits (Parus major) using a playback experiment to manipulate perceived predation danger...
October 1, 2016: Physiology & Behavior
Jing-Ya Li, Li-Xin Yuan, Gen-Ming Zhang, Li Zhou, Ying Gao, Qing-Bin Li, Che Chen
OBJECTIVE: To investigate the efficacy and safety of the Chinese herbal therapeutic regimen of activating blood circulation (TRABC) in treatment of hypertensive intracerebral hemorrhage (HICH). METHODS: This was a multi-center prospective randomized open-label blinded-endpoint (PROBE) trial with HICH admitted to 12 hospitals. Totally 240 participants were randomized to the treatment group treated with TRABC in addition to conventional Western treatment or the control group with conventional Western treatment equally for 3 months...
May 2016: Chinese Journal of Integrative Medicine
Suzanne E England
Mary Gordon's short story, Mrs. Cassidy's Last Year, is about a family trying to cope, not only with Mrs. Cassidy, who has dementia and is physically and verbally abusive, but also with her elderly husband's difficulties caring for her at home. Mr. Cassidy's dilemma, expressed through the dissonance between his private "inner talk" of emotions and desires that he feels are forbidden and shameful, and his insistence to his son and daughter-in-law that his wife is still the woman he married and her care is not too much for him...
June 22, 2016: Gerontologist
Albert J Yoo, Olvert A Berkhemer, Puck S S Fransen, Lucie A van den Berg, Debbie Beumer, Hester F Lingsma, Wouter J Schonewille, Marieke E S Sprengers, René van den Berg, Marianne A A van Walderveen, Ludo F M Beenen, Marieke J H Wermer, Geert J Lycklama À Nijeholt, Jelis Boiten, Sjoerd F M Jenniskens, Joseph C J Bot, Anna M M Boers, Henk A Marquering, Yvo B W E M Roos, Robert J van Oostenbrugge, Diederik W J Dippel, Aad van der Lugt, Wim H van Zwam, Charles B L M Majoie
BACKGROUND: Whether infarct size modifies intra-arterial treatment effect is not certain, particularly in patients with large infarcts. We examined the effect of the baseline Alberta Stroke Program Early CT Score (ASPECTS) on the safety and efficacy of intra-arterial treatment in a subgroup analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN). METHODS: MR CLEAN was a randomised, controlled, open-label, phase 3 trial of intra-arterial treatment in patients (aged ≥18 years from the Netherlands) with proximal arterial occlusion of the anterior circulation, given intra-arterial treatment within 6 h of stroke onset...
June 2016: Lancet Neurology
Andrew D Barreto, Christopher V Fanale, Andrei V Alexandrov, Kevin C Gaffney, Farhaan S Vahidy, Claude B Nguyen, Amrou Sarraj, Mohammad Rahbar, James C Grotta, Sean I Savitz
OBJECTIVE: It is estimated that one of four ischemic strokes are noticed upon awakening and are not candidates for intravenous recombinant tissue plasminogen activator (rtPA) because their symptoms are >3 hours from last seen normal (LSN). We tested the safety of rtPA in a multicenter, single-arm, prospective, open-label study (NCT01183533) in patients with wake-up stroke (WUS). METHODS: We aimed to enroll 40 WUS patients with disabling deficits. Patients were 18 to 80 years of age, National Institutes of Health Stroke Scale (NIHSS) ≤25, and selected only on the appearance of noncontrast computed tomography (ie, over one-third middle cerebral artery territory hypodensity)...
August 2016: Annals of Neurology
Ming Lu, Xiao-Hong Zhu, Wei Chen
NAD(+) and NADH play key roles in cellular respiration. Intracellular redox state defined by the NAD(+) /NADH ratio (RX) reflects the cellular metabolic and physiopathological status. By taking advantage of high/ultrahigh magnetic field strengths, we have recently established a novel in vivo (31) P MRS-based NAD assay for noninvasive and quantitative measurements of intracellular NAD concentrations and redox state in animal and human brains at 16.4 T, 9.4 T and 7 T. To explore its potential for clinical application, in this study we investigated the feasibility of assessing the NAD metabolism and redox state in human brain at a lower field of 4 T by incorporating the (1) H-decoupling technique with the in vivo (31) P NAD assay...
July 2016: NMR in Biomedicine
Yasuaki Abe, Keisuke Maruyama, Shigeomi Yokoya, Akio Noguchi, Eishi Sato, Motoo Nagane, Yoshiaki Shiokawa
OBJECTIVE Chronic subdural hematoma (CSDH) is widely treated by drainage through a bur hole opening. However, whether and how preexisting comorbidities causing disturbance of consciousness affect patient outcomes remains unclear. METHODS The authors analyzed 188 consecutive patients with CSDH who were surgically treated at the Neurosurgery Institute of the Kyorin University School of Medicine between 2010 and 2012 and followed them for more than 90 days. The mean patient age was 77.0 years (range 33-101 years) and 56 were women...
May 27, 2016: Journal of Neurosurgery
Chunyan Lei, Bo Wu, Ming Liu, Ge Tan, Quantao Zeng
CDATA[Whether original intracerebral hemorrhage (ICH) score can be used to predict clinical outcomes in patients with SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy, systemic disease, hypertension, or undetermined) classification remains an open question. This study obtained data related to consecutive acute patients with ICH from 21 tertiary hospitals in China during January 2012 to December 2014. Using the SMASH-U method, patients were classified into 6 subtypes. Favorable functional outcome and mortality was obtained after ICH at the 3 months...
2016: Current Neurovascular Research
Omar Khan, Navid Seraji-Bozorgzad, Fen Bao, Sara Razmjou, Christina Caon, Carla Santiago, Zahid Latif, Rimma Aronov, Imad Zak, Natalia Ashtamker, Scott Kolodny, Corey Ford, Yulia Sidi
BACKGROUND AND PURPOSE: Conventional MRI techniques do not necessarily provide information about multiple sclerosis (MS) disease pathology or progression. Nonconventional MRI techniques, including proton magnetic resonance spectroscopy ((1) H-MRS), are increasingly used to improve the qualitative and quantitative specificity of MR images. This study explores potential correlations between MRI measures of disease and disability progression as measured by the Expanded Disability Status Scale (EDSS), Functional Systems (FS), and ambulation index scores in a unique cohort of MS patients treated with glatiramer acetate that has been closely monitored for over 20 years...
May 23, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
M Irem Baharoglu, Charlotte Cordonnier, Rustam Al-Shahi Salman, Koen de Gans, Maria M Koopman, Anneke Brand, Charles B Majoie, Ludo F Beenen, Henk A Marquering, Marinus Vermeulen, Paul J Nederkoorn, Rob J de Haan, Yvo B Roos
BACKGROUND: Platelet transfusion after acute spontaneous primary intracerebral haemorrhage in people taking antiplatelet therapy might reduce death or dependence by reducing the extent of the haemorrhage. We aimed to investigate whether platelet transfusion with standard care, compared with standard care alone, reduced death or dependence after intracerebral haemorrhage associated with antiplatelet therapy use. METHODS: We did this multicentre, open-label, masked-endpoint, randomised trial at 60 hospitals in the Netherlands, UK, and France...
June 25, 2016: Lancet
Darrin J Lee, Arjang Ahmadpour, Tamar Binyamin, Brian C Dahlin, Kiarash Shahlaie, Ben Waldau
Cerebral venous sinus thrombosis (CVST) is an uncommon form of stroke with a variable presentation, ranging from headaches, to coma and death. Although the American Stroke Association has developed guidelines for the treatment of CVST, data are sparse on the outcome after treatment with anticoagulation, thrombolysis, and thrombectomy. In this retrospective review, we describe the 5-year UC Davis experience with spontaneous CVST. Forty-one patients (mean age 37.5±23.1, range 0-96 years; 29 female) were identified with CVST...
April 19, 2016: Journal of Neurointerventional Surgery
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