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feline seizures

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https://www.readbyqxmd.com/read/28720302/clinical-reasoning-in-feline-epilepsy-which-combination-of-clinical-information-is-useful
#1
Gabriela-Dumitrita Stanciu, Rowena Mary Anne Packer, Akos Pakozdy, Gheorghe Solcan, Holger Andreas Volk
We sought to identify the association between clinical risk factors and the diagnosis of idiopathic epilepsy (IE) or structural epilepsy (SE) in cats, using statistical models to identify combinations of discrete parameters from the patient signalment, history and neurological examination findings that could suggest the most likely diagnosis. Data for 138 cats with recurrent seizures were reviewed, of which 110 were valid for inclusion. Seizure aetiology was classified as IE in 57% and SE in 43% of cats. Binomial logistic regression analyses demonstrated that pedigree status, older age at seizure onset (particularly >7years old), abnormal neurological examinations, and ictal vocalisation were associated with a diagnosis of SE compared to IE, and that ictal salivation was more likely to be associated with a diagnosis of IE than SE...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28613179/unsupervised-learning-of-spike-pattern-for-seizure-detection-and-wavefront-estimation-of-high-resolution-micro-electrocorticographic-%C3%AE-ecog-data
#2
Yilin Song, Yao Wang, Jonathan Viventi
For the past few years, we have developed flexible, active, multiplexed recording devices for high resolution recording over large, clinically relevant areas in the brain. While this technology has enabled a much higher-resolution view of the electrical activity of the brain, the analytical methods to process, categorize and respond to the huge volumes of seizure data produced by these devices have not yet been developed. In this work we proposed an unsupervised learning framework for spike analysis, which by itself reveals spike pattern...
June 9, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28606140/imepitoin-is-well-tolerated-in-healthy-and-epileptic-cats
#3
Odilo Engel, Thilo von Klopmann, Arianna Maiolini, Jessica Freundt-Revilla, Andrea Tipold
BACKGROUND: Epilepsy in the cat is a serious medical condition. To date there are no licensed treatments for feline epilepsy and no well-controlled clinical studies on the efficacy or safety of antiepileptic drugs in cats. The aim of this study was to collect tolerability data and first exploratory efficacy data of imepitoin in both healthy and epileptic cats. RESULTS: In two tolerability studies, 30 healthy cats received imepition twice daily in doses of 0, 30, 40 or 80 mg/kg bodyweight for 30 days...
June 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28605962/novel-approach-to-magnetic-resonance-imaging-of-epileptic-dogs-t2-relaxometry-of-the-brain-with-emphasised-hippocampus
#4
Borbála A Lorincz, Agustina Anson, Péter Csébi, Gábor Bajzik, Gergely Biró, Alexander Tichy, Balázs B Lorincz, Rita Garamvölgyi
Hippocampal sclerosis is the most common imaging finding of intractable human epilepsy, and it may play an important role in canine and feline epileptogenesis and seizure semiology, too. The magnetic resonance imaging (MRI) criteria of hippocampal sclerosis are T2 hyperintensity, shrinkage and loss of internal structure. The detection of these changes is often challenging by subjective visual assessment of qualitative magnetic resonance (MR) images. The recognition is more reliable with quantitative MR methods, such as T2 relaxometry...
June 2017: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/28382749/feline-temporal-lobe-epilepsy-review-of-the-experimental-literature
#5
REVIEW
S Kitz, J G Thalhammer, U Glantschnigg, M Wrzosek, A Klang, P Halasz, M N Shouse, A Pakozdy
Accumulating evidence suggests that epileptic seizures originating from the temporal lobe (TL) occur in cats. Typically, affected animals have clinically focal seizures with orofacial automatisms including salivation, facial twitching, lip smacking, chewing, licking, and swallowing. Motor arrest and autonomic and behavioral signs also may occur. Many affected cats have magnetic resonance imaging (MRI) changes within the hippocampus or histopathologically confirmed hippocampal sclerosis or necrosis. From the 1950s to the 1980s, cats frequently were used as animal models for neurophysiological experiments and electrophysiological studies, from which important basic knowledge about epilepsy originated, but which has been rarely cited in clinical veterinary studies...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27515840/magnetic-resonance-features-of-the-feline-hippocampus-in-epileptic-and-non-epileptic-cats-a-blinded-retrospective-multi-observer-study
#6
Anne Christine Claßen, Sibylle Kneissl, Johann Lang, Alexander Tichy, Akos Pakozdy
BACKGROUND: Hippocampal necrosis in cats has been reported to be associated with epileptic seizures. Magnetic resonance imaging (MRI) features of temporal lobe (TL) abnormalities in epileptic cats have been described but MR images from epileptic and non-epileptic individuals have not yet been systematically compared. TL abnormalities are highly variable in shape, size and signal, and therefore may lead to varying evaluations by different specialists. The aim of this study was to investigate whether there were differences in the appearance of the TL between epileptic and non-epileptic cats, and whether there were any relationships between TL abnormalities and seizure semiologies or other clinical findings...
August 11, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27145746/imaging-diagnosis-magnetic-resonance-imaging-findings-in-a-cat-with-systemic-reactive-angioendotheliomatosis
#7
Amy E Schkeeper, Jill Narak, Richard Weiss
A 10-year-old, castrated male domestic short-haired cat was presented with an acute history of seizures, lethargy, anorexia, vomiting, and dyspnea. Magnetic resonance imaging of the brain showed multifocal areas of gray matter T2-weighted hyperintensity. The lesions did not enhance with intravenous contrast. The cat was diagnosed at necropsy with feline systemic reactive angioendotheliomatosis, a rare vascular proliferative disorder for which a treatment has not yet been identified. This report is the first to describe associated magnetic resonance imaging changes for this disease...
March 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27052436/diagnostic-techniques-to-detect-the-epileptogenic-zone-pathophysiological-and-presurgical-analysis-of-epilepsy-in-dogs-and-cats
#8
REVIEW
Daisuke Hasegawa
The use and availability of magnetic resonance imaging (MRI) and other neurosurgical devices is rapidly increasing in the field of veterinarian medicine. Coincident with these technological advances, there is an increased expectation to treat drug resistant epilepsy in dogs and cats by epilepsy surgery. However, the presurgical evaluation of epileptic animals, by using methodologies to detect the epileptogenic zone for example, have yet to become established in common practice. The epileptogenic zone, defined as the minimum amount of cortex to produce seizure freedom, consists of five conceptual cortical abnormal 'zones': symptomatogenic, irritative, seizure-onset, structurally abnormal (epileptogenic lesion) and functional deficit...
September 2016: Veterinary Journal
https://www.readbyqxmd.com/read/26783020/outbreak-of-thiamine-deficiency-in-cats-associated-with-the-feeding-of-defective-dry-food
#9
Ya-Pei Chang, Po-Yu Chiu, Chung-Tien Lin, I-Hsuan Liu, Chen-Hsuan Liu
Objectives The objective of this study was to determine disease progression, association between neurological signs and magnetic resonance imaging (MRI) findings, and long-term outcome in feline thiamine deficiency associated with defective dry food. Methods The clinical records of 17 cats diagnosed with thiamine deficiency related to a defective dry food were examined and data collected. The thiamine level in the food was analysed by liquid chromatography-tandem mass spectrometry. Results The thiamine level in the food was below the recommendation of the National Research Council...
April 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/26690830/levetiracetam-in-the-management-of-feline-audiogenic-reflex-seizures-a-randomised-controlled-open-label-study
#10
Mark Lowrie, Sarah Thomson, Claire Bessant, Andrew Sparkes, Robert J Harvey, Laurent Garosi
Objectives Currently, there are no published randomised, controlled veterinary trials evaluating the efficacy of antiepileptic medication in the treatment of myoclonic seizures. Myoclonic seizures are a hallmark of feline audiogenic seizures (FARS). Methods This prospective, randomised, open-label trial compared the efficacy and tolerability of levetiracetam (20-25 mg/kg q8h) with phenobarbital (3-5 mg/kg q12h) in cats with suspected FARS that experienced myoclonic seizures. Cats were included that had ⩾12 myoclonic seizure days during a prospective 12 week baseline period...
February 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/26623376/intravenous-lipid-emulsion-and-dexmedetomidine-for-treatment-of-feline-permethrin-intoxication-a-report-from-4-cases
#11
G Ceccherini, F Perondi, I Lippi, G Grazia, V Marchetti
Four cases of feline permethrin intoxication are described. The cause of intoxication is the application of canine permethrin spot-on product (Advantix®, Bayer) by the owners. Principal clinical guidelines recommends the use of anticonvulsant drugs to treat seizures or neurological symptoms after initial stabilization and dermal decontamination. The use of lipid emulsion had an increasing interest in the last decade for treatment of toxicosis caused by lipophylic drugs as reported in human and in veterinary medical practices...
2015: Open veterinary journal
https://www.readbyqxmd.com/read/26343530/in-vivo-models-of-cortical-acquired-epilepsy
#12
REVIEW
Sylvain Chauvette, Sara Soltani, Josée Seigneur, Igor Timofeev
The neocortex is the site of origin of several forms of acquired epilepsy. Here we provide a brief review of experimental models that were recently developed to study neocortical epileptogenesis as well as some major results obtained with these methods. Most of neocortical seizures appear to be nocturnal and it is known that neuronal activities reveal high levels of synchrony during slow-wave sleep. Therefore, we start the review with a description of mechanisms of neuronal synchronization and major forms of synchronized normal and pathological activities...
February 15, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/26314300/international-veterinary-epilepsy-task-force-consensus-proposal-outcome-of-therapeutic-interventions-in-canine-and-feline-epilepsy
#13
Heidrun Potschka, Andrea Fischer, Wolfgang Löscher, Ned Patterson, Sofie Bhatti, Mette Berendt, Luisa De Risio, Robyn Farquhar, Sam Long, Paul Mandigers, Kaspar Matiasek, Karen Muñana, Akos Pakozdy, Jacques Penderis, Simon Platt, Michael Podell, Clare Rusbridge, Veronika Stein, Andrea Tipold, Holger A Volk
Common criteria for the diagnosis of drug resistance and the assessment of outcome are needed urgently as a prerequisite for standardized evaluation and reporting of individual therapeutic responses in canine epilepsy. Thus, we provide a proposal for the definition of drug resistance and partial therapeutic success in canine patients with epilepsy. This consensus statement also suggests a list of factors and aspects of outcome, which should be considered in addition to the impact on seizures. Moreover, these expert recommendations discuss criteria which determine the validity and informative value of a therapeutic trial in an individual patient and also suggest the application of individual outcome criteria...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26234889/gm1-gangliosidosis-in-a-japanese-domestic-cat-a-new-variant-identified-in-hokkaido-japan
#14
Hiroshi Ueno, Osamu Yamato, Takeshi Sugiura, Moeko Kohyama, Akira Yabuki, Kenjiro Miyoshi, Kazuya Matsuda, Tsuyoshi Uchide
A male Japanese domestic cat with retarded growth in Hokkaido, Japan, showed progressive motor dysfunction, such as ataxia starting at 3 months of age and tremors, visual disorder and seizure after 4 months of age. Finally, the cat died of neurological deterioration at 9 months of age. Approximately half of the peripheral blood lymphocytes had multiple abnormal vacuoles. Magnetic resonance imaging showed bisymmetrical hyperintensity in the white matter of the parietal and occipital lobes in the forebrain on T2-weighted and fluid-attenuated inversion recovery images, and mild encephalatrophy of the olfactory bulbs and temporal lobes...
January 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26215252/feline-hippocampal-and-piriform-lobe-necrosis-as-a-consequence-of-severe-cluster-seizures-in-two-cats-in-finland
#15
Sara Fors, Sofie Van Meervenne, Janis Jeserevics, Mindaugas Rakauskas, Sigitas Cizinauskas
Feline hippocampal and piriform lobe necrosis (FHN) has been reported from several countries worldwide and is considered an important aetiology for feline epileptic seizures. The aetiology of FHN remains unclear, however it is suspected that FHN might occur secondary to intense epileptic activity as described in humans and dogs although this has not yet been documented in cats. The purpose of our report is to describe the first cases of FHN in Finland diagnosed by magnetic resonance imaging (MRI) and histopathology...
July 28, 2015: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/25971245/mucopolysaccharidosis-like-phenotype-in-feline-sandhoff-disease-and-partial-correction-after-aav-gene-therapy
#16
Heather L Gray-Edwards, Brandon L Brunson, Merrilee Holland, Adrien-Maxence Hespel, Allison M Bradbury, Victoria J McCurdy, Patricia M Beadlescomb, Ashley N Randle, Nouha Salibi, Thomas S Denney, Ronald J Beyers, Aime K Johnson, Meredith L Voyles, Ronald D Montgomery, Diane U Wilson, Judith A Hudson, Nancy R Cox, Henry J Baker, Miguel Sena-Esteves, Douglas R Martin
Sandhoff disease (SD) is a fatal neurodegenerative disease caused by a mutation in the enzyme β-N-acetylhexosaminidase. Children with infantile onset SD develop seizures, loss of motor tone and swallowing problems, eventually reaching a vegetative state with death typically by 4years of age. Other symptoms include vertebral gibbus and cardiac abnormalities strikingly similar to those of the mucopolysaccharidoses. Isolated fibroblasts from SD patients have impaired catabolism of glycosaminoglycans (GAGs). To evaluate mucopolysaccharidosis-like features of the feline SD model, we utilized radiography, MRI, echocardiography, histopathology and GAG quantification of both central nervous system and peripheral tissues/fluids...
September 2015: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/25916687/audiogenic-reflex-seizures-in-cats
#17
Mark Lowrie, Claire Bessant, Robert J Harvey, Andrew Sparkes, Laurent Garosi
OBJECTIVES: This study aimed to characterise feline audiogenic reflex seizures (FARS). METHODS: An online questionnaire was developed to capture information from owners with cats suffering from FARS. This was collated with the medical records from the primary veterinarian. Ninety-six cats were included. RESULTS: Myoclonic seizures were one of the cardinal signs of this syndrome (90/96), frequently occurring prior to generalised tonic-clonic seizures (GTCSs) in this population...
April 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/25881213/inter-observer-agreement-of-canine-and-feline-paroxysmal-event-semiology-and-classification-by-veterinary-neurology-specialists-and-non-specialists
#18
Rowena M A Packer, Mette Berendt, Sofie Bhatti, Marios Charalambous, Sigitas Cizinauskas, Luisa De Risio, Robyn Farquhar, Rachel Hampel, Myfanwy Hill, Paul J J Mandigers, Akos Pakozdy, Stephanie M Preston, Clare Rusbridge, Veronika M Stein, Fran Taylor-Brown, Andrea Tipold, Holger A Volk
BACKGROUND: Advances in mobile technology mean vets are now commonly presented with videos of paroxysmal events by clients, but the consistency of the interpretation of these videos has not been investigated. The objective of this study was to investigate the level of agreement between vets (both neurology specialists and non-specialists) on the description and classification of videos depicting paroxysmal events, without knowing any results of diagnostic workup. An online questionnaire study was conducted, where participants watched 100 videos of dogs and cats exhibiting paroxysmal events and answered questions regarding: epileptic seizure presence (yes/no), seizure type, consciousness status, and the presence of motor, autonomic and neurobehavioural signs...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/25779802/inter-observer-agreement-of-canine-and-feline-paroxysmal-event-semiology-and-classification-by-veterinary-neurology-specialists-and-non-specialists
#19
Rowena Ma Packer, Mette Berendt, Sofie Bhatti, Marios Charalambous, Sigitas Cizinauskas, Luisa De Risio, Robyn Farquhar, Rachel Hampel, Myfanwy Hill, Paul Jj Mandigers, Akos Pakozdy, Stephanie M Preston, Clare Rusbridge, Veronika M Stein, Fran Taylor-Brown, Andrea Tipold, Holger A Volk
BACKGROUND: Advances in mobile technology mean vets are now commonly presented with videos of paroxysmal events by clients, but the consistency of the interpretation of these videos has not been investigated. The objective of this study was to investigate the level of agreement between vets (both neurology specialists and non-specialists) on the description and classification of videos depicting paroxysmal events, without knowing any results of diagnostic workup. An online questionnaire study was conducted, where participants watched 100 videos of dogs and cats exhibiting paroxysmal events and answered questions regarding: epileptic seizure presence (yes/no), seizure type, consciousness status, and the presence of motor, autonomic and neurobehavioural signs...
December 2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/25039445/development-of-dialysis-disequilibrium-like-clinical-signs-during-postobstructive-management-of-feline-urethral-obstruction
#20
Cassandra J Ostroski, Edward S Cooper
OBJECTIVE: To describe the clinical features, treatment, and outcome of a cat with acute neurologic signs subsequent to relief of urethral obstruction and rapid resolution of severe azotemia, suggesting a process similar to dialysis disequilibrium syndrome. CASE SUMMARY: A male castrated domestic short-hair cat was presented for weakness and dull mentation. Initial physical examination was consistent with urethral obstruction and laboratory data demonstrated severe azotemia, hyperkalemia, and acidemia...
July 2014: Journal of Veterinary Emergency and Critical Care
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