keyword
https://read.qxmd.com/read/37850066/out-of-hospital-rescue-medication-in-dogs-with-emergency-seizure-disorders-an-owner-perspective
#21
JOURNAL ARTICLE
Charlotte Kähn, Sofie F M Bhatti, Sebastian Meller, Nina Meyerhoff, Holger A Volk, Marios Charalambous
BACKGROUND: Emergency seizure disorders such as status epilepticus and cluster seizures are unlikely to cease spontaneously while prolonged seizure activity become progressively more resistant to treatment. Early administration of rescue medication in canine epileptic patients, in particular benzodiazepines, at seizure onset by the owners can be life-saving and brain protecting. Clinical studies in dogs evaluating the use of rescue medication in hospital environment exist, however, the owner perspective has not been assessed to date...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37835731/-resistance-is-futile-a-pilot-study-into-pseudoresistance-in-canine-epilepsy
#22
JOURNAL ARTICLE
Filip Kajin, Nina Meyerhoff, Marios Charalambous, Holger Andreas Volk
Epilepsy is a common neurological disorder in veterinary practice, complicated by frequent occurrence of medication-resistant epilepsy. In human medicine, it has been noted that some patients with medication-resistant epilepsy have in fact other reasons for their apparent medication-resistance. The aim of this retrospective study was to describe the issue of pseudoresistance using as an example a population of dogs presented with presumed medication-resistant epilepsy and provide an in-depth review of what is known in human medicine about pseudoresistant epilepsy...
October 6, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37675074/duration-of-constant-rate-infusion-with-diazepam-or-propofol-for-canine-cluster-seizures-and-status-epilepticus
#23
JOURNAL ARTICLE
Giulia Cagnotti, Sara Ferrini, Giorgia Di Muro, Eleonora Avilii, Alessandra Favole, Antonio D'Angelo
INTRODUCTION: Constant rate infusion (CRI) of benzodiazepines or propofol (PPF) is a therapeutic option for cluster seizures (CS) and status epilepticus (SE) in canine patients non-responding to first-line benzodiazepines or non-anesthetics. However, specific indications for optimal duration of CRI are lacking. The aim of this study was to determine the effect of duration of anesthetic CRI on outcome and length of hospital stay in dogs with refractory seizure activity of different etiology...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37614731/effects-of-high-dose-docosahexaenoic-acid-supplementation-as-an-add-on-therapy-for-canine-idiopathic-epilepsy-a-pilot-study
#24
JOURNAL ARTICLE
Tomohiro Yonezawa, Cris Niño Bon B Marasigan, Yuki Matsumiya, Shingo Maeda, Tomoki Motegi, Yasuyuki Momoi
BACKGROUND: The anti-epileptic effects of docosahexaenoic acid (DHA) in dogs and humans remain controversial. The dosage and efficacy of DHA were various in the previous reports. AIM: The effects of high-dose DHA supplementation as add-on therapy for idiopathic epilepsy in dogs were evaluated. METHODS: An open-label clinical trial was designed in this pilot study. Six dogs (median age: 6 years) with idiopathic epilepsy were included. All the patients were diagnosed with idiopathic epilepsy using magnetic MRI and cerebrospinal fluid examination (median: 2...
July 2023: Open Veterinary Journal
https://read.qxmd.com/read/37572005/mild-to-moderate-increases-in-activity-are-associated-with-increased-seizure-incidence-in-dogs-with-idiopathic-epilepsy-receiving-anti-epileptic-drugs
#25
JOURNAL ARTICLE
S Cameron, K M Grady, S P Kent, M M Sousa
OBJECTIVE: Epilepsy is a chronic disorder, and approximately 25% to 30% of dogs with epilepsy are refractory to anti-epileptic drugs. As increased activity has been shown to reduce seizure frequency in people with epilepsy, the goal of this study was to evaluate the relationship between deviation from baseline activity and seizure incidence in dogs with epilepsy. MATERIALS AND METHODS: Activity and seizure data were obtained using a canine activity monitoring device and owner observed seizure logs in 53 dogs with idiopathic epilepsy receiving anti-epileptic drugs...
August 12, 2023: Journal of Small Animal Practice
https://read.qxmd.com/read/37520003/survey-of-electroencephalography-usage-and-techniques-for-dogs
#26
JOURNAL ARTICLE
Julia Luca, Samantha McCarthy, Thomas Parmentier, Michal Hazenfratz, Alex Zur Linden, Luis Gaitero, Fiona M K James
BACKGROUND: Canine epilepsy is a chronic common neurologic condition where seizures may be underreported. Electroencephalography (EEG) is the patient-side test providing an objective diagnostic criterion for seizures and epilepsy. Despite this, EEG is thought to be rarely used in veterinary neurology. OBJECTIVES: This survey study aims to better understand the current canine EEG usage and techniques and barriers in veterinary neurology. METHODS: The online Qualtrics link was distributed via listserv to members of the American College of Veterinary Internal Medicine (ACVIM) Neurology Specialty and the European College of Veterinary Neurology (ECVN), reaching at least 517 veterinary neurology specialists and trainees worldwide...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37505876/very-low-frequency-spike-wave-complex-partial-motor-seizure-mimicking-canine-idiopathic-head-tremor-syndrome-in-a-dog
#27
Mihai Musteata, Raluca Ștefănescu, Denis Gabriel Borcea, Gheorghe Solcan
Canine idiopathic head tremor syndrome (CIHTS) represents a benign condition characterized by episodic, uncontrolled movement of the head. Even though the condition might be an expression of a partial motor epilepsy, to date, there is a limited number of studies describing the electroencephalographic features. In this report, we describe the case of a dog diagnosed with partial motor epilepsy resembling CIHTS symptomatology, a new slow spike-wave complex pattern similar to that of Lennox-Gastaut syndrome in humans identified on electroencephalographic examination...
July 19, 2023: Veterinary Sciences
https://read.qxmd.com/read/37448119/a-rare-finding-of-double-barr-bodies-and-x-monosomy-x-trisomy-mosaicism-in-a-dog-with-presumed-idiopathic-epilepsy
#28
Nicholas T Noto, Terje Raudsepp, Ellie Kolb, Devon W Hague, Melissa M Lara, Michael F Rosser
A 4-year-old spayed female Border Collie dog presented to the Neurology and Neurosurgery service for an approximately five-month history of seizures. A complete neurodiagnostic workup was performed and did not reveal any significant abnormalities. The patient's seizures were well controlled with a combination of anticonvulsants. During a manual blood smear review at a follow-up appointment, double Barr bodies were identified in segmented neutrophils. Karyotyping revealed that the patient is mosaic for X-monosomy and X-trisomy, a finding that has never been reported in a dog and is rarely reported in people...
July 13, 2023: Veterinary Clinical Pathology
https://read.qxmd.com/read/37443914/defining-a-good-death-exploring-veterinarians-perceptions-of-companion-animal-euthanasia
#29
JOURNAL ARTICLE
Lori R Kogan, Kathleen A Cooney
This study was designed to determine how veterinarians define a good euthanasia experience. This information is used to generate a working definition of companion animal euthanasia that aligns with animal welfare standards and pet owners' expectations. An electronic survey distributed via veterinary-related social media (Facebook, Instagram) and listservs were completed by 249 veterinarians who perform feline and/or canine euthanasia. Our results suggest that very few veterinarians feel their veterinary school training adequately prepared them for euthanasia...
June 26, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37393038/the-role-of-neuroinflammation-in-canine-epilepsy
#30
JOURNAL ARTICLE
Eva-Lotta von Rüden, Heidrun Potschka, Andrea Tipold, Veronika M Stein
The lack of therapeutics that prevent the development of epilepsy, improve disease prognosis or overcome drug resistance represents an unmet clinical need in veterinary as well as in human medicine. Over the past decade, experimental studies and studies in human epilepsy patients have demonstrated that neuroinflammatory processes are involved in epilepsy development and play a key role in neuronal hyperexcitability that underlies seizure generation. Targeting neuroinflammatory signaling pathways may provide a basis for clinically relevant disease-modification strategies in general, and moreover, could open up new therapeutic avenues for human and veterinary patients with drug-resistant epilepsy...
2023: Veterinary Journal
https://read.qxmd.com/read/37304610/a-prospective-study-on-clinical-signs-management-outcomes-and-delayed-neurologic-sequelae-due-to-metaldehyde-poisoning-in-26-dogs
#31
JOURNAL ARTICLE
Guillaume Fabien Dutil, Philippe Berny
BACKGROUND: Metaldehyde poisoning in dogs is well known and described issue. Several studies focused on the incidence, epidemiological features, and clinical and pathological findings associated with this intoxication. However, there are no prospective studies of metaldehyde poisoning and late-onset seizures. AIMS: To prospectively describe clinical signs, therapeutic management, outcomes, and delayed-onset seizures due to metaldehyde poisoning in dogs. METHODS: A 15-month prospective study on dogs with a diagnosis of metaldehyde poisoning, either via phone call to the animal poison control center or analysis at the toxicology laboratory in Lyon, France...
May 2023: Open Veterinary Journal
https://read.qxmd.com/read/37275612/quantification-of-phenobarbital-induced-ataxia-in-dogs-with-idiopathic-epilepsy
#32
JOURNAL ARTICLE
Tamara Sherif, Friederike Twele, Sebastian Meller, Alexandra Müller-Anders, Holger A Volk
Ataxia is a clinical sign seen in several neurological diseases and has been reported as an adverse effect of anti-seizure medication such as phenobarbital (PB). Efforts to objectify canine ataxia in order to provide appropriate treatment or monitor adverse effects of drugs remain limited. Automated quantitative gait analysis can be useful for the acquisition of objective data for the evaluation and monitoring of ataxia in dogs. The aim of this prospective clinical study was to examine the gait characteristics of dogs with PB induced ataxia and compare them with healthy dogs using a computer- and treadmill-based gait analysis system...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37235429/congenital-portosystemic-shunts-in-dogs-and-cats-treatment-complications-and-prognosis
#33
REVIEW
Alexandros O Konstantinidis, Katerina K Adamama-Moraitou, Michail N Patsikas, Lysimachos G Papazoglou
Congenital portosystemic shunts (CPSS) are a common vascular anomaly of the liver in dogs and cats. Clinical signs of CPSS are non-specific and may wax and wane, while laboratory findings can raise the clinical suspicion for CPSS, but they are also not specific. Definitive diagnosis will be established by evaluation of liver function tests and diagnostic imaging. The aim of this article is to review the management, both medical and surgical, complications, and prognosis of CPSS in dogs and cats. Attenuation of the CPSS is the treatment of choice and may be performed by open surgical intervention using ameroid ring constrictors, thin film banding, and partial or complete suture ligation or by percutaneous transvenous coil embolization...
May 12, 2023: Veterinary Sciences
https://read.qxmd.com/read/37232512/investigation-of-the-presence-of-specific-neural-antibodies-in-dogs-with-epilepsy-or-dyskinesia-using-murine-and-human-assays
#34
JOURNAL ARTICLE
Lea Hemmeter, Christian G Bien, Corinna I Bien, Andrea Tipold, Jasmin Neßler, Andrea Bathen-Nöthen, Kaspar Matiasek, Maik Dahlhoff, Clare Rusbridge, Carina Rotter Black, Kai Rentmeister, Holger A Volk, Andrea Fischer
BACKGROUND: Autoimmune mechanisms represent a novel category for causes of seizures and epilepsies in humans, and LGI1-antibody associated limbic encephalitis occurs in cats. HYPOTHESIS/OBJECTIVES: To investigate the presence of neural antibodies in dogs with epilepsy or dyskinesia of unknown cause using human and murine assays modified for use in dogs. ANIMALS: Fifty-eight dogs with epilepsy of unknown cause or suspected dyskinesia and 57 control dogs...
2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/37150317/pathophysiology-of-drug-resistant-canine-epilepsy
#35
JOURNAL ARTICLE
Heidrun Potschka, Andrea Fischer, Wolfgang Löscher, Holger A Volk
Drug resistance continues to be a major clinical problem in the therapeutic management of canine epilepsies with substantial implications for quality of life and survival times. Experimental and clinical data from human medicine provided evidence for relevant contributions of intrinsic severity of the disease as well as alterations in pharmacokinetics and -dynamics to failure to respond to antiseizure medications. In addition, several modulatory factors have been identified that can be associated with the level of therapeutic responses...
2023: Veterinary Journal
https://read.qxmd.com/read/36950536/corrigendum-phenotypic-characterization-of-idiopathic-epilepsy-and-epilepsy-of-unknown-cause-in-irish-setters
#36
Marta Plonek, Montse M Diaz-Espineira, Quirine E M Stassen, Koen M Santifort, Peter A J Leegwater, Paul J J Mandigers
[This corrects the article DOI: 10.3389/fvets.2022.1066094.].
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/36911639/clinical-and-mri-findings-of-a-suspected-cortical-malformation-presented-as-a-giant-cerebral-pseudomass-in-a-german-shepherd-dog
#37
Jos Jacqueline Bongers, Rodrigo Gutierrez-Quintana, Gawain Hammond, Roberto José-López
A 5-month-old German Shepherd dog was presented with cluster seizures. MR imaging showed a large irregular pseudomass in the central region of the cranial cavity, compatible with a malformation of cortical development. Despite the extensive changes, the patient was neurologically normal interictally 1 year following diagnosis.
March 2023: Clinical Case Reports
https://read.qxmd.com/read/36899667/identification-of-a-novel-idiopathic-epilepsy-risk-locus-and-a-variant-in-the-ccdc85a-gene-in-the-dutch-partridge-dog
#38
JOURNAL ARTICLE
Evy Beckers, Sofie F M Bhatti, Mario Van Poucke, Ingeborgh Polis, Frédéric Farnir, Filip Van Nieuwerburgh, Paul Mandigers, Luc Van Ham, Luc Peelman, Bart J G Broeckx
(1) Idiopathic epilepsy (IE) is thought to have a genetic cause in several dog breeds. However, only two causal variants have been identified to date, and few risk loci are known. No genetic studies have been conducted on IE in the Dutch partridge dog (DPD), and little has been reported on the epileptic phenotype in this breed. (2) Owner-filled questionnaires and diagnostic investigations were used to characterize IE in the DPD. A genome-wide association study (GWAS) involving 16 cases and 43 controls was performed, followed by sequencing of the coding sequence and splice site regions of a candidate gene within the associated region...
February 23, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/36864510/a-six-month-prospective-randomised-double-blinded-placebo-controlled-crossover-dietary-trial-design-to-investigate-the-potential-of-psychobiotics-on-seizure-semiology-and-comorbidities-in-canine-epilepsy-study-protocol
#39
JOURNAL ARTICLE
Teresa Schmidt, Sebastian Meller, Nina Meyerhoff, Friederike Twele, Brian Zanghi, Holger Andreas Volk
BACKGROUND: Epilepsy is the most common chronic neurological disease in dogs. More than two-thirds of these patients suffer from associated behavioural comorbidities. The latter could have their origin in partially overlapping pathomechanisms, with the intestinal microbiome as a potential key link between them. The current arsenal of drugs for epilepsy management remains limited. Most canine patients continue to have seizures despite treatment and the occurrence of comorbidities is not sufficiently addressed, limiting quality of life of affected dogs and owners...
March 3, 2023: BMC Veterinary Research
https://read.qxmd.com/read/36823232/hippocampal-expression-of-the-cannabinoid-receptor-type-1-in-canine-epilepsy
#40
JOURNAL ARTICLE
D Kostic, M Nowakowska, J Freundt Revilla, F Attig, K Rohn, F Gualtieri, W Baumgärtner, H Potschka, A Tipold
Canine drug-resistant epilepsy is a prevailing issue in veterinary neurology. Alternative or additional treatment with cannabinoids is showing promising results in seizure management. A crucial component of the endocannabinoid system, cannabinoid receptor type 1 (CB1R), is heavily involved in the control of neurotransmitter release. Knowledge of its distribution in the epileptic brain would serve a better understanding of disease pathology and application of cannabinoids in dogs with epilepsy. CB1R distribution was assessed in sub-regions of hippocampus of dogs with idiopathic epilepsy, structural epilepsy and without cerebral pathology...
February 23, 2023: Scientific Reports
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