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https://www.readbyqxmd.com/read/28062844/phenobarbital-administration-every-eight-hours-improvement-of-seizure-management-in-idiopathic-epileptic-dogs-with-decreased-phenobarbital-elimination-half-life
#1
F Stabile, C R Barnett, L De Risio
Estimated prevalence of canine idiopathic epilepsy is 0.6 per cent in the first-opinion canine population in the UK. Phenobarbital monotherapy has been reported to reduce/eradicate seizure activity in 60-93 per cent of idiopathic epileptic dogs (IEDs). The objective of this study was to evaluate safety and efficacy of the administration of phenobarbital orally every eight hours in IEDs with phenobarbital elimination half-life less than 20 hours. Medical records of 10 IEDs in which steady state trough serum phenobarbital levels were within the reference range and phenobarbital elimination half-life had become less than 20 hours following prolonged administration every 12 hours were reviewed...
January 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28024876/neuronal-ceroid-lipofuscinosis-ncl-is-caused-by-the-entire-deletion-of-cln8-in-the-alpenl%C3%A3-ndische-dachsbracke-dog
#2
M Hirz, M Drögemüller, A Schänzer, V Jagannathan, E Dietschi, H H Goebel, W Hecht, S Laubner, M J Schmidt, F Steffen, M Hilbe, K Köhler, C Drögemüller, C Herden
Neuronal ceroid lipofuscinoses (NCLs) are inherited lysosomal storage diseases that have been described in a variety of dog breeds, where they are caused by different mutations in different genes. However, the causative gene defect in the breed Alpenländische Dachsbracke remained unknown so far. Here we present two confirmed cases of NCL in Alpenländische Dachsbracke dogs from different litters of the same sire with a different dam harboring the same underlying novel mutation in the CLN8 gene. Case 1, a 2-year-old male Alpenländische Dachsbracke was presented with neurological signs including disorientation, character changes including anxiety states and aggressiveness, sudden blindness and reduction of food intake...
December 19, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27995128/intravenous-topiramate-pharmacokinetics-in-dogs-with-naturally-occurring-epilepsy
#3
Irene Vuu, Lisa D Coles, Patricia Maglalang, Ilo E Leppik, Greg Worrell, Daniel Crepeau, Usha Mishra, James C Cloyd, Edward E Patterson
RATIONALE: Barriers to developing treatments for human status epilepticus include the inadequacy of experimental animal models. In contrast, naturally occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. The objectives of this study were to characterize the pharmacokinetics of an intravenous (IV) dose of topiramate (TPM) in dogs with epilepsy and evaluate its effect on intracranial electroencephalographic (iEEG) features...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27966545/the-novel-homozygous-kcnj10-c-986t-c-p-leu329pro-variant-is-pathogenic-for-the-sesame-east-homologue-in-malinois-dogs
#4
Mario Van Poucke, Kimberley Stee, Sofie F M Bhatti, An Vanhaesebrouck, Leslie Bosseler, Luc J Peelman, Luc Van Ham
SeSAME/EAST syndrome is a multisystemic disorder in humans, characterised by seizures, sensorineural deafness, ataxia, developmental delay and electrolyte imbalance. It is exclusively caused by homozygous or compound heterozygous variations in the KCNJ10 gene. Here we describe a similar syndrome in two families belonging to the Malinois dog breed, based on clinical, neurological, electrodiagnostic and histopathological examination. Genetic analysis detected a novel pathogenic KCNJ10 c.986T>C (p.(Leu329Pro)) variant that is inherited in an autosomal recessive way...
December 14, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27932282/serum-cardiac-troponin-i-in-canine-syncope-and-seizures
#5
E Dutton, J Dukes-McEwan, P J Cripps
OBJECTIVE: To determine if serum cardiac troponin I (cTnI) concentration distinguishes between cardiogenic syncope and collapsing dogs presenting with either generalized epileptic seizures (both with and without cardiac disease) or vasovagal syncope. ANIMALS: Seventy-nine prospectively recruited dogs, grouped according to aetiology of collapse: generalized epileptic seizures (group E), cardiogenic syncope (group C), dogs with both epileptic seizures and cardiac disease (group B), vasovagal syncope (group V) or unclassified (group U)...
December 5, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27891564/a-homozygous-pign-missense-mutation-in-soft-coated-wheaten-terriers-with-a-canine-paroxysmal-dyskinesia
#6
Ana L Kolicheski, Gary S Johnson, Tendai Mhlanga-Mutangadura, Jeremy F Taylor, Robert D Schnabel, Taroh Kinoshita, Yoshiko Murakami, Dennis P O'Brien
Hereditary paroxysmal dyskinesias (PxD) are a heterogeneous group of movement disorders classified by frequency, duration, and triggers of the episodes. A young-adult onset canine PxD has segregated as an autosomal recessive trait in Soft-Coated Wheaten Terriers. The medical records and videos of episodes from 25 affected dogs were reviewed. The episodes of hyperkinesia and dystonia lasted from several minutes to several hours and could occur as often as >10/day. They were not associated with strenuous exercise or fasting but were sometimes triggered by excitement...
January 2017: Neurogenetics
https://www.readbyqxmd.com/read/27856943/owner-perception-of-focal-seizures-in-canine-epilepsy
#7
R M A Packer, R Lucas, H A Volk
No abstract text is available yet for this article.
November 17, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27829458/retrospective-epidemiological-study-of-canine-epilepsy-in-japan-using-the-international-veterinary-epilepsy-task-force-classification-2015-2003-2013-etiological-distribution-risk-factors-survival-time-and-lifespan
#8
Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Fujiwara-Igarashi, Michio Fujita
BACKGROUND: Epilepsy is the most common neurological disease in veterinary practice. However, contrary to human medicine, epilepsy classification in veterinary medicine had not been clearly defined until recently. A number of reports on canine epilepsy have been published, reflecting in part updated proposals from the human epilepsy organization, the International League Against Epilepsy. In 2015, the International Veterinary Epilepsy Task Force (IVETF) published a consensus report on the classification and definition of canine epilepsy...
November 9, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27807850/temporal-behavior-of-seizures-and-interictal-bursts-in-prolonged-intracranial-recordings-from-epileptic-canines
#9
Hoameng Ung, Kathryn A Davis, Drausin Wulsin, Joost Wagenaar, Emily Fox, John J McDonnell, Ned Patterson, Charles H Vite, Gregory Worrell, Brian Litt
OBJECTIVE: Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic intracranial recordings in canine epilepsy. METHODS: Continuous, yearlong intracranial electroencephalography (iEEG) recordings from four dogs with naturally occurring epilepsy were analyzed for seizures and interictal bursts...
December 2016: Epilepsia
https://www.readbyqxmd.com/read/27534261/omega-3-fatty-acids-%C3%A1-3-fatty-acids-in-epilepsy-animal-models-and-human-clinical-trials
#10
Christopher M DeGiorgio, Ameer Y Taha
INTRODUCTION: There is growing interest in alternative and nutritional therapies for drug resistant epilepsy. ῳ-3 fatty acids such as fish or krill oil are widely available supplements used to lower triglycerides and enhance cardiovascular health. ῳ-3 fatty acids have been studied extensively in animal models of epilepsy. Yet, evidence from randomized controlled clinical trials in epilepsy is at an early stage. AREAS COVERED: This report focuses on the key ῳ-3 fatty acids DHA and EPA, their incorporation into the lipid bilayer, modulation of ion channels, and mechanisms of action in reducing excitability within the central nervous system...
October 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27491217/insights-into-the-pathogenesis-and-treatment-of-krabbe-disease
#11
REVIEW
Ernesto Roque Bongarzone, Maria Luisa Escolar, Steven James Gray, Tal Kafri, Charles Herman Vite, Mark Steven Sands
Krabbe disease (globoid cell leukodystrophy, GLD) is an inherited disease caused by a deficiency in the lysosomal enzyme galactocerebrosidase (GALC). The major galactosylated lipid degraded by GALC is galactosylceramide. However, GALC is also responsible for the degradation of galactosylsphingosine (psychosine), a highly cytotoxic glycolipid. It has been hypothesized that GALC-deficiency leads to psychosine accumulation that preferentially kills oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system...
June 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/27464854/seizure-forecasting-and-the-preictal-state-in-canine-epilepsy
#12
Yogatheesan Varatharajah, Ravishankar K Iyer, Brent M Berry, Gregory A Worrell, Benjamin H Brinkmann
The ability to predict seizures may enable patients with epilepsy to better manage their medications and activities, potentially reducing side effects and improving quality of life. Forecasting epileptic seizures remains a challenging problem, but machine learning methods using intracranial electroencephalographic (iEEG) measures have shown promise. A machine-learning-based pipeline was developed to process iEEG recordings and generate seizure warnings. Results support the ability to forecast seizures at rates greater than a Poisson random predictor for all feature sets and machine learning algorithms tested...
February 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/27458589/canine-butterfly-glioblastomas-a-neuroradiological-review
#13
John H Rossmeisl, Kemba Clapp, Theresa E Pancotto, Samantha Emch, John L Robertson, Waldemar Debinski
In humans, high-grade gliomas may infiltrate across the corpus callosum resulting in bihemispheric lesions that may have symmetrical, winged-like appearances. This particular tumor manifestation has been coined a "butterfly" glioma (BG). While canine and human gliomas share many neuroradiological and pathological features, the BG morphology has not been previously reported in dogs. Here, we describe the magnetic resonance imaging (MRI) characteristics of BG in three dogs and review the potential differential diagnoses based on neuroimaging findings...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27342435/chirally-pure-prodrugs-and-their-converting-enzymes-lead-to-high-supersaturation-and-rapid-transcellular-permeation-of-benzodiazepines
#14
Mamta Kapoor, Narsihmulu Cheryala, Davin Rautiola, Gunda I Georg, James C Cloyd, Ronald A Siegel
Water-soluble prodrugs can be rapidly converted by enzymes to hydrophobic drugs, whose aqueous thermodynamic solubilities are low, but are maintained in aqueous solution at supersaturated concentrations due to slow precipitation kinetics. Recently, we investigated avizafone (AVF) in combination with Aspergillus oryzae protease as a prodrug/enzyme system intended to produce supersaturated diazepam (DZP). Several fold enhancement of permeation of supersaturated DZP across Madin-Darby canine kidney II-wild type (MDCKII-wt) monolayers was observed, compared to saturated DZP solutions...
August 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27329504/quality-of-life-aspects-in-idiopathic-epilepsy-in-dogs
#15
A Wessmann, H A Volk, R M A Packer, M Ortega, T J Anderson
Quality of life (QoL) plays a significant role in the treatment of dogs with idiopathic epilepsy (IE), yet is so far understudied. This study describes the outcome evaluation of an online questionnaire based on the carer's perception focusing on 62 QoL questions in 159 dogs with IE. Results showed that seizure frequency, but not seizure severity or presence of cluster seizures, was significantly associated with carer-perceived dog's QoL. Dogs receiving third-line antiepileptic drugs had a significantly lower perceived QoL than those that did not...
September 3, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27227650/correction-forecasting-seizures-using-bivariate-intracranial-eeg-measures-and-svm-in-naturally-occurring-canine-epilepsy
#16
Benjamin H Brinkmann, Edward E Patterson, Charles Vite, Vincent M Vasoli, Daniel Crepeau, Matt Stead, J Jeffry Howbert, Vladimir Cherkassky, Joost B Wagenaar, Brian Litt, Gregory A Worrell
[This corrects the article DOI: 10.1371/journal.pone.0133900.].
2016: PloS One
https://www.readbyqxmd.com/read/27211611/neuronal-ceroid-lipofuscinosis-associated-with-an-mfsd8-mutation-in-chihuahuas
#17
Akanksha Ashwini, Antonio D'Angelo, Osamu Yamato, Cristina Giordano, Giulia Cagnotti, Tom Harcourt-Brown, Tendai Mhlanga-Mutangadura, Juyuan Guo, Gary S Johnson, Martin L Katz
The neuronal ceroid lipofuscinoses (NCLs) are hereditary neurodegenerative disorders characterized by progressive declines in neurological functions, seizures, and premature death. NCLs result from mutations in at least 13 different genes. Canine versions of the NCLs can serve as important models in developing effective therapeutic interventions for these diseases. NCLs have been described in a number of dog breeds, including Chihuahuas. Studies were undertaken to further characterize the pathology of Chihuahua NCL and to verify its molecular genetic basis...
August 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27144775/magnetic-resonance-imaging-of-intracranial-inflammatory-conditions-in-dogs-sensitivity-of-subtraction-images-versus-pre-and-post-gadolinium-t1-weighted-image-pairs
#18
Helen Dirrig, Christopher R Lamb
Ante mortem diagnosis of canine meningoencephalitis is usually based on the results of neurologic examination, cerebrospinal fluid analysis and magnetic resonance (MR) imaging. It has been hypothesized that subtraction MR imaging may increase the sensitivity of MR for intracranial inflammatory lesions compared to conventional post-gadolinium T1-weighted imaging. Sensitivity of pre- and post-gadolinium (C-/C+) image pairs and dynamic subtraction (DS) images was compared in a retrospective diagnostic accuracy study of 52 dogs with inflammatory cerebrospinal fluid and 67 dogs with idiopathic epilepsy...
July 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27052436/diagnostic-techniques-to-detect-the-epileptogenic-zone-pathophysiological-and-presurgical-analysis-of-epilepsy-in-dogs-and-cats
#19
REVIEW
Daisuke Hasegawa
The use and availability of magnetic resonance imaging (MRI) and other neurosurgical devices is rapidly increasing in the field of veterinarian medicine. Coincident with these technological advances, there is an increased expectation to treat drug resistant epilepsy in dogs and cats by epilepsy surgery. However, the presurgical evaluation of epileptic animals, by using methodologies to detect the epileptogenic zone for example, have yet to become established in common practice. The epileptogenic zone, defined as the minimum amount of cortex to produce seizure freedom, consists of five conceptual cortical abnormal 'zones': symptomatogenic, irritative, seizure-onset, structurally abnormal (epileptogenic lesion) and functional deficit...
September 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27034258/crowdsourcing-reproducible-seizure-forecasting-in-human-and-canine-epilepsy
#20
Benjamin H Brinkmann, Joost Wagenaar, Drew Abbot, Phillip Adkins, Simone C Bosshard, Min Chen, Quang M Tieng, Jialune He, F J Muñoz-Almaraz, Paloma Botella-Rocamora, Juan Pardo, Francisco Zamora-Martinez, Michael Hills, Wei Wu, Iryna Korshunova, Will Cukierski, Charles Vite, Edward E Patterson, Brian Litt, Gregory A Worrell
SEE MORMANN AND ANDRZEJAK DOI101093/BRAIN/AWW091 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE  : Accurate forecasting of epileptic seizures has the potential to transform clinical epilepsy care. However, progress toward reliable seizure forecasting has been hampered by lack of open access to long duration recordings with an adequate number of seizures for investigators to rigorously compare algorithms and results. A seizure forecasting competition was conducted on kaggle.com using open access chronic ambulatory intracranial electroencephalography from five canines with naturally occurring epilepsy and two humans undergoing prolonged wide bandwidth intracranial electroencephalographic monitoring...
June 2016: Brain: a Journal of Neurology
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