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JOURNAL ARTICLE
Yashaswinii Polaka, Evangeline P Christina, Karthik Krishna Ramakrishnan, Arunkumar Mohanakrishnan, Paarthipan Natarajan
Background Renal insufficiency, a critical concern in native and transplant kidneys, necessitates effective screening modalities for evaluation and management. Grayscale sonography has been a cornerstone in renal diagnostics, providing basic anatomical insights such as renal length, cortical thickness, and collecting system dilatation. Despite technological advancements, its impact on the differential diagnosis or management of renal disease remains limited, often showing normal findings in the presence of severe renal dysfunction...
March 2024: Curēus
#2
JOURNAL ARTICLE
Alessandra Palmisano, Marta D'Angelo, Ilaria Gandolfini, Marco Delsante, Giovanni Maria Rossi, Micaela Gentile, Enrico Fiaccadori, Paolo Cravedi, Umberto Maggiore
INTRODUCTION: It is unclear whether kidney transplant recipients with a biopsy diagnosis as a "borderline" acute T-cell mediated rejection (TCMR) requires the treatment with intravenous (iv) steroids pulse plus/minus intensification of the maintenance therapy (TRT) in comparison with the simple clinical follow-up (F-UP). METHODS: We retrospectively followed a consecutive series of kidney transplant recipients diagnosed with a borderline acute TCMR at biopsy by surveillance or clinical indication for 12 months and compared TRT and F-UP groups...
April 17, 2024: Transplant Immunology
#3
JOURNAL ARTICLE
Rajesh Nachiappa Ganesh, Edward A Graviss, Duc Nguyen, Ziad El-Zaatari, Lillian Gaber, Roberto Barrios, Luan Truong, Alton B Farris
INTRODUCTION: Semi-quantitative scoring of various parameters in renal biopsy is accepted as an important tool to assess disease activity and prognostication. There are concerns on the impact of inter-observer variability in its prognostic utility, generating a need for computerized quantification. METHODS: We studied 94 patients with renal biopsies, 45 with native diseases and 49 transplant patients with index biopsies for Polyomavirus nephropathy. Chronicity scores were evaluated using two methods...
April 17, 2024: Human Pathology
#4
REVIEW
Olga Balafa, Beatriz Fernandez-Fernandez, Alberto Ortiz, Evangelia Dounousi, Robert Ekart, Charles J Ferro, Patrick B Mark, Jose M Valdivielso, Lucia Del Vecchio, Francesca Mallamaci
Sex (biologically determined) and gender (socially constructed) modulate manifestations and prognosis of a vast number of diseases, including cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD remains the leading cause of death in CKD patients. Population-based studies indicate that women present a higher prevalence of CKD and experience less CVD than men in all CKD stages, although this is not as clear in patients on dialysis or transplantation. When compared to the general population of the same sex, CKD has a more negative impact on women on kidney replacement therapy...
March 2024: Clinical Kidney Journal
#5
JOURNAL ARTICLE
Miko Yu, Kristen L King, Lindsey M Maclay, S Ali Husain, Jesse D Schold, Sumit Mohan
Administrative claims data could provide a unique opportunity to identify acute rejection events by use of specific anti-rejection medications and validate rejection data reported to the Organ Procurement Transplant Network (OPTN). This retrospective cohort study examined differences in registry-reported events and those identified via claims data among adult kidney transplant recipients from 2012-2017 using Standard Analysis Files from the United States Renal Data System. Rejection rates, survival estimates, and center-level differences were assessed using each approach...
April 16, 2024: American Journal of Transplantation
#6
JOURNAL ARTICLE
Tung-Ling Chung, Nai-Ching Chen, Chun-Hao Yin, Ching-Chih Lee, Chien-Liang Chen
BACKGROUND: Conflicting evidence exists regarding the relationship between socioeconomic status and access to or outcomes after kidney transplantation. This study analyzed the effects of individual and neighborhood socioeconomic status on kidney transplant access and outcomes in Taiwan. METHODS: We used a retrospective cohort study design and performed comparisons using the Cox proportional hazards model after adjusting for risk factors. Data were collected from the National Health Insurance Bureau of Taiwan data (2003-2012)...
April 18, 2024: Journal of Nephrology
#7
JOURNAL ARTICLE
Steve Biko Tobada, Valérie Chatelet, Clemence Bechade, Antoine Lanot, Annabel Boyer, Cécile Couchoud, Fatouma Toure, Sabrina Boime, Thierry Lobbedez, Mathilde Beaumier
BACKGROUND: Social deprivation is associated with lower peritoneal dialysis (PD) uptake. This study was carried out to evaluate the role of social deprivation on the outcome of PD. METHODS: This was a retrospective study of data extracted from the Renal Epidemiology and Information Network registry for patients older than 18 years who started PD in metropolitan France between 1 January 2017 and 30 June 2018. The end of the observation period was 31 December 2020...
April 17, 2024: Peritoneal Dialysis International
#8
JOURNAL ARTICLE
Angela Ernst, Heinz Regele, Christos Chatzikyrkou, Amélie Dendooven, Sándor Turkevi-Nagy, Ineke Tieken, Rainer Oberbauer, Roman Reindl-Schwaighofer, Daniel Abramowicz, Rachel Hellemans, Annick Massart, Danica Galesic Ljubanovic, Petar Senjug, Bojana Maksimovic, Volker Aßfalg, Ivan Neretljak, Christina Schleicher, Marian Clahsen-van Groningen, Nika Kojc, Carla L Ellis, Christine E Kurschat, Leandra Lukomski, Dirk Stippel, Michael Ströhlein, Florian G Scurt, Joris J Roelofs, Jesper Kers, Ana Harth, Christian Jungck, Albino Eccher, Isabel Prütz, Martin Hellmich, Francesco Vasuri, Deborah Malvi, Wolfgang Arns, Jan U Becker
BACKGROUND AND HYPOTHESIS: The decision for acceptance or discard of the increasingly rare and marginal brain-dead donor kidneys in Eurotransplant (ET) countries has to be made without solid evidence. Thus, we developed and validated flexible clinicopathological scores called 2-Step Scores for the prognosis of delayed graft function (DGF) and one-year death-censored transplant loss (1y-tl) reflecting the current practice of six ET countries including Croatia and Belgium. METHODS: The training set was n=620 for DGF and n=711 for 1y-tl, with validation sets n=158 and n=162...
April 17, 2024: Nephrology, Dialysis, Transplantation
#9
JOURNAL ARTICLE
Gianmarco Lombardi, Pietro Manuel Ferraro, Elisa De Tomi, Matteo Bargagli, Andrea Spasiano, Giovanni Gambaro
BACKGROUND AND HYPOTHESIS: Chronic kidney disease (CKD) is a growing global health concern. Recent research has indicated sex disparities in CKD-related complications, yet the impact of sex differences on critical kidney function levels that trigger these complications and mortality remains inadequately documented. METHODS: We investigated sex-specific disparities in CKD-related complications and mortality according to eGFR levels. We analyzed NHANES data spanning from 1999 to 2018, including adult participants with an eGFR of 15-150 ml/min per 1...
April 17, 2024: Nephrology, Dialysis, Transplantation
#10
MULTICENTER STUDY
Luka Flegar, Johannes Huber, Juliane Putz, Christian Thomas, Hendrik Apel, Bernd Wullich, Frank Friedersdorff, Guido Fechner, Manuel Ritter, Karoline Kernig, Karl Weigand, Hans Heynemann, Michael Stöckle, Philip Zeuschner
PURPOSE: An abnormal lower urinary tract poses significant challenges for transplant surgeons. Besides the ureteral anastomosis to an ileal conduit, there are diverse complex reconstructive solutions. Due to its rarity, standardization and teaching of complex urinary diversion is extremely difficult. METHODS: The indications and outcomes of complex urinary diversions after kidney transplantation (KT) were retrospectively investigated at eight urologic transplant centers including a current follow-up...
April 17, 2024: World Journal of Urology
#11
JOURNAL ARTICLE
Carla Ramirez-Amoros, Maria San Basilio, Virginia Amesty, Susana Rivas, Roberto Lobato, Carlota Fernandez-Camblor, Pedro Lopez-Pereira, Maria Jose Martinez-Urrutia
BACKGROUND: Renal transplantation is currently the best treatment option for patients with end-stage renal disease. However, the use of kidneys from donors under 6 years of age as a possibility to increase the organ pool in pediatric recipients remains a controversial matter. We aimed to investigate whether donor age is associated to the long-term functionality of the renal graft. Likewise, we analyzed the adaptation of the graft to the ascending functional requirements in the pediatric patient...
May 2024: Pediatric Transplantation
#12
JOURNAL ARTICLE
Francesc Vigués, Begoña Etcheverry, José I Perez Reggeti, Josep Maria Gaya, Angelo Territo, Andrea Gallioli, Camille Berquin, Giuseppe Basile, José F Suárez, Maria Fiol, Oscar Buisan, Lluís Riera, Thomas Prudhomme, Nicolas Doumerc, Alessio Pecoraro, Alberto Breda
BACKGROUND AND OBJECTIVE: Orthotopic kidney transplantation (KT) has been proposed as an option for patients ineligible for heterotopic KT. In this scenario, orthotopic robot-assisted KT (oRAKT) represents a novel, minimally invasive alternative to the open approach. Here we describe the largest oRAKT series of patients, with a focus on the surgical technique, perioperative surgical outcomes, and functional results. METHODS: We queried prospectively maintained databases from three referral centers to identify patients who underwent oRAKT and evaluated surgical and functional outcomes...
April 15, 2024: European Urology
#13
JOURNAL ARTICLE
Abdallah Damin Abukhalil, Haya Alyazouri, Reem Alsheikh, Hadeel Kahla, Minna Mousa, Hosniyeh Ladadweh, Ni'meh Al-Shami, Yousef Sahoury, Hani Naseef, Abdullah Rabba
BACKGROUND: Acute kidney injury (AKI) is a major medical problem affecting patients' quality of life and healthcare costs. OBJECTIVES: This study evaluated the severity, risk factors, and outcomes of patients diagnosed with acute kidney injury (AKI), including community-acquired AKI (CA-AKI) and hospital-acquired AKI (HA-AKI), who were admitted to tertiary institutions in Palestine. METHODS: This retrospective cross-sectional study was conducted at multiple tertiary care hospitals in Palestine by reviewing patient charts from January 2020 to March 2023...
2024: TheScientificWorldJournal
#14
Hugo Bes-Berlandier, Margaux Garzaro, Claire Rouzaud, Sylvain Bodard, Emmanuelle Bille, Maxence Ficheux, Dominique Cazals-Hatem, Nicolas Veziris, Fanny Lanternier, Olivier Lortholary
Immune reconstitution inflammatory syndrome (IRIS) has been reported in immunocompromised patients with disseminated Mycobacterium genavense . Management relies on high-dose corticosteroids. We describe two cases of late-onset corticosteroid-refractory IRIS related to disseminated infection in a HIV-positive patient and a renal transplant patient who had a favorable outcome with a monoclonal TNF-α blocker.
April 15, 2024: Heliyon
#15
REVIEW
Babak Ghajavand, Carla Avesani, Peter Stenvinkel, Annette Bruchfeld
The rising global incidence of chronic inflammatory diseases calls for innovative and sustainable medical solutions. Brewers' spent grain (BSG), a byproduct of beer production, presents a unique opportunity in this regard. This review explores the multifaceted health benefits of BSG, with a focus on managing chronic kidney disease (CKD). BSG is identified as a potent prebiotic with potential as a therapeutic agent in CKD. We emphasize the role of gut dysbiosis in CKD and discuss how BSG could help mitigate metabolic derangements resulting from dysbiosis and CKD...
April 13, 2024: Journal of Renal Nutrition
#16
JOURNAL ARTICLE
Rima Obeid, Husain Awwad, Gunnar Henrik Heine, Insa E Emrich, Danilo Fliser, Adam M Zawada, Jürgen Geisel
OBJECTIVES: Trimethylamine N-oxide (TMAO) is a gut bacteria mediated liver metabolite of dietary betaine, choline, and carnitine which is excreted by glomerular filtration. We studied whether TMAO is associated with cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). METHODS: Among 478 patients with CKD stage G2 (n = 104), G3a (n = 163), G3b (n = 123), and G4 (n = 88), we studied the association between fasting plasma concentrations of TMAO, choline or betaine at baseline and kidney function, prevalent CVD and future renal outcomes during a mean follow-up of 5...
April 13, 2024: Journal of Renal Nutrition
#17
JOURNAL ARTICLE
Armin Frille, Johannes Broschewitz, Isabella Bettine Metelmann, Matthias Steinert, Maximilian von Laffert, Hubert Wirtz, Alexandra Wald, Sebastian Kraemer
BACKGROUND: Lung cancer following lung transplantation (LT) may require thoracic surgery (TS). There is an urgent need for data on surgical feasibility, clinical and surgical characteristics, as well as outcome data. METHODS: We reviewed the medical records of LT patients who had undergone TS at the University Hospital Leipzig between the years 2000 and 2022. Data on medical and surgical history, pulmonary function test, arterial blood gas analysis, six-minute walking distance test, and surgical approach, perioperative management, anesthesiologic, and surgical procedures were analyzed...
March 29, 2024: Journal of Thoracic Disease
#18
JOURNAL ARTICLE
Rita Eid, Anne Scemla, Magali Giral, Nadia Arzouk, Dominique Bertrand, Marie-Noëlle Peraldi, Laurent Mesnard, Helene Longuet, Mehdi Maanaoui, Geoffroy Desbuissons, Edouard Lefevre, Renaud Snanoudj
BACKGROUND: Efficacy and safety of belatacept have not been specifically reported for kidney transplantations from donors after circulatory death. METHODS: In this retrospective multicenter paired kidney study, we compared the outcome of kidney transplantations with a belatacept-based to a calcineurin inhibitor (CNI)-based immunosuppression. We included all kidney transplant recipients from donors after uncontrolled or controlled circulatory death performed in our center between February 2015 and October 2020 and treated with belatacept (n = 31)...
May 2024: Transplantation Direct
#19
JOURNAL ARTICLE
Kristin J Dolan, Ayse Arikan, Anna M Banc-Husu, Muhammad Umair Mukhtar Mian, Sameer Thadani, Jeffrey Quinn Lee, Lacey Stribling, N Thao N Galván, John Goss, Rahul Baijal, Moreshwar S Desai
BACKGROUND: Intraoperative Continuous Renal Replacement Therapy (iCRRT) can prevent life-threatening complications, facilitate fluid management, and maintain metabolic homeostasis during liver transplantation (LT) in adults. There is a paucity of data in pediatric LT. We evaluated the safety, efficacy, and impact on survival of iCRRT in pediatric LT. METHODS: We conducted a retrospective cohort study of all children requiring CRRT pre-OLT at a quaternary children's hospital from 2014 to 2022...
April 2024: Clinical Transplantation
#20
JOURNAL ARTICLE
Rikako Oki, Kohei Unagami, Taro Banno, Toshihito Hirai, Kazuya Omoto, Tomokazu Shimizu, Sekiko Taneda, Junichi Hoshino, Toshio Takagi, Hideki Ishida
BACKGROUND: The number of marginal living kidney donors has increased. Medically complex donors who have hypertension, older age, or low estimated glomerular filtration rate (eGFR) have been more likely to be used. METHODS: We conducted a retrospective cohort study of living kidney donors at a single center. We analyzed 309 living donors and divided them into three groups: group with older donors (aged ≥70 years) (n = 41), middle-aged (aged 46-69 years) (n = 239), and young donors (aged <46 years) (N = 29)...
April 14, 2024: Clinical and Experimental Nephrology
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