Eric M Parise, Trevonn M Gyles, Arthur Godino, Omar K Sial, Caleb J Browne, Lyonna F Parise, Angélica Torres-Berrío, Marine Salery, Romain Durand-de Cuttoli, Matthew T Rivera, Astrid M Cardona-Acosta, Leanne Holt, Tamara Markovic, Yentl Y van der Zee, Zachary S Lorsch, Flurin Cathomas, Juliet B Garon, Collin Teague, Orna Issler, Peter J Hamilton, Carlos A Bolaños-Guzmán, Scott J Russo, Eric J Nestler
Major depressive disorder (MDD) is linked to impaired structural and synaptic plasticity in limbic brain regions. Astrocytes, which regulate synapses and are influenced by chronic stress, likely contribute to these changes. We analyzed astrocyte gene profiles in the nucleus accumbens (NAc) of humans with MDD and mice exposed to chronic stress. Htra1 , which encodes an astrocyte-secreted protease targeting the extracellular matrix (ECM), was significantly downregulated in the NAc of males but upregulated in females in both species...
April 15, 2024: bioRxiv