keyword
https://read.qxmd.com/read/32141047/safety-of-aortic-aneurysm-repair-8-weeks-after-percutaneous-coronary-intervention-for-coronary-artery-disease-a-cohort-study
#21
JOURNAL ARTICLE
Vito A Mannacio, Luigi Mannacio, Mario Monaco, Anita Antignano, Raffaele Giordano, Giovanni B Pinna, Antonino Musumeci, Gabriele Iannelli
Guidelines advice against dual antiplatelet therapy (DAPT) discontinuation less than 12 months after percutaneous coronary intervention with drug-eluting stents (DES-PCI). However, any delay of necessary surgery in patients with descending thoracic (DTA) or abdominal aortic aneurysm (AAA), treated by DES-PCI, increases the risk of aneurysm rupture/dissection. We evaluated the safety of 8-week waiting time between DES-PCI and endovascular aortic repair (EVAR). 1152 consecutive patients with coronary artery disease (CAD) needing elective DTA or AAA repair were enrolled and divided into two groups...
March 5, 2020: Updates in Surgery
https://read.qxmd.com/read/31466339/remodeling-of-human-osteochondral-defects-via-raav-mediated-co-overexpression-of-tgf-%C3%AE-and-igf-i-from-implanted-human-bone-marrow-derived-mesenchymal-stromal-cells
#22
JOURNAL ARTICLE
Stephanie Morscheid, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Magali Cucchiarini
The application of chondrogenic gene sequences to human bone marrow-derived mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative activities of these cells as a means to enhance the processes of cartilage repair using indirect cell transplantation procedures that may improve the repopulation of cartilage lesions. In the present study, we examined the feasibility of co-delivering the highly competent transforming growth factor beta (TGF-β) with the insulin-like growth factor I (IGF-I) in hMSCs via recombinant adeno-associated virus (rAAV) vector-mediated gene transfer prior to implantation in a human model of osteochondral defect (OCD) ex vivo that provides a microenvironment similar to that of focal cartilage lesions...
August 28, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/31178632/a-new-animal-model-of-insulin-glucose-dynamics-in-the-intraperitoneal-space-enhances-closed-loop-control-performance
#23
JOURNAL ARTICLE
Ankush Chakrabarty, Justin M Gregory, L Merkle Moore, Philip E Williams, Ben Farmer, Alan D Cherrington, Peter Lord, Brian Shelton, Don Cohen, Howard C Zisser, Francis J Doyle, Eyal Dassau
Current artificial pancreas systems (AP) operate via subcutaneous (SC) glucose sensing and SC insulin delivery. Due to slow diffusion and transport dynamics across the interstitial space, even the most sophisticated control algorithms in on-body AP systems cannot react fast enough to maintain tight glycemic control under the effect of exogenous glucose disturbances caused by ingesting meals or performing physical activity. Recent efforts made towards the development of an implantable AP have explored the utility of insulin infusion in the intraperitoneal (IP) space: a region within the abdominal cavity where the insulin-glucose kinetics are observed to be much more rapid than the SC space...
April 2019: Journal of Process Control
https://read.qxmd.com/read/30248060/myotonic-dystrophy-type-2-data-from-the-serbian-registry
#24
JOURNAL ARTICLE
Ivo Bozovic, Stojan Peric, Jovan Pesovic, Bogdan Bjelica, Milos Brkusanin, Ivana Basta, Marija Bozic, Ivan Sencanic, Ana Marjanovic, Marija Brankovic, Dusanka Savic-Pavicevic, Vidosava Rakocevic-Stojanovic
BACKGROUND: Myotonic dystrophy type 2 (DM2) is a multisystem disorder, mostly presented with mild but heterogeneous spectrum of symptoms. OBJECTIVE: The aim of this research was to provide detailed sociodemographic, clinical and laboratory data of a large DM2 cohort from the Serbian registry. METHODS: In 2008, we started to prospectively enter data of all DM patients. We also retrospectively collected data of patients hospitalized from 1990 until 2008...
2018: Journal of Neuromuscular Diseases
https://read.qxmd.com/read/29870275/the-clinical-impact-of-glp-1-receptor-agonists-in-type-2-diabetes-focus-on-the-long-acting-analogs
#25
JOURNAL ARTICLE
Helena W Rodbard
GLP-1 receptor agonists (GLP-1 RAs), introduced for clinical use in 2005, have excellent potency in reducing HbA1c and mean glucose, improving fasting plasma glucose, inducing weight loss or protecting against the weight gain associated with insulin therapy, reducing appetite, and delaying gastric emptying. Two of these medications, liraglutide and semaglutide, appear to have cardioprotective effects as reflected in cardiovascular outcomes studies. The GLP-1 RAs are associated with gastrointestinal side effects that tend to diminish over time...
June 2018: Diabetes Technology & Therapeutics
https://read.qxmd.com/read/29523133/obesity-as-disruptor-of-the-female-fertility
#26
REVIEW
Erica Silvestris, Giovanni de Pergola, Raffaele Rosania, Giuseppe Loverro
Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the 'hypothalamic pituitary ovarian axis', and frequently suffer of menstrual dysfunction leading to anovulation and infertility. Besides the hormone disorders and subfertility that are common in the polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation...
March 9, 2018: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/29330027/selective-estrogen-receptor-modulator-ormeloxifene-suppresses-embryo-implantation-via-inducing-mir-140-and-targeting-insulin-like-growth-factor-1-receptor-in-rat-uterus
#27
JOURNAL ARTICLE
Vijay Kumar Sirohi, Kanchan Gupta, Rohit Kumar, Vinay Shukla, Anila Dwivedi
Ormeloxifene, the non-steroidal SERM contraceptive, inhibits endometrial receptivity and embryo implantation via countering nidatory estrogen. However, the molecular mechanism of ormeloxifene action responsible for its contraceptive efficacy still remains unclear. Herein, we aimed to identify the miRNAs modulated under the influence of ormeloxifene and to explore their role in endometrial receptivity and embryo implantation. By doing microRNA sequencing analysis, a total of 168 miRNAs were found to be differentially expressed in uterine tissue of ormeloxifene-treated rats, on day 5 (10:00 h) of pregnancy i...
April 2018: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/28916763/maternal-diabetes-causes-developmental-delay-and-death-in-early-somite-mouse-embryos
#28
JOURNAL ARTICLE
Jing Zhao, Theodorus B M Hakvoort, Jan M Ruijter, Aldo Jongejan, Jan Koster, Sigrid M A Swagemakers, Aleksandar Sokolovic, Wouter H Lamers
Maternal diabetes causes congenital malformations and delays embryonic growth in the offspring. We investigated effects of maternal diabetes on mouse embryos during gastrulation and early organogenesis (ED7.5-11.5). Female mice were made diabetic with streptozotocin, treated with controlled-release insulin implants, and mated. Maternal blood glucose concentrations increased up to embryonic day (ED) 8.5. Maternal hyperglycemia induced severe growth retardation (approx.1 day) in 53% of the embryos on ED8.5, death in most of these embryos on ED9...
September 15, 2017: Scientific Reports
https://read.qxmd.com/read/28868248/the-window-of-implantation-is-closed-by-estrogen-via-insulin-like-growth-factor-1-pathway
#29
JOURNAL ARTICLE
Ryosuke Kobayashi, Jumpei Terakawa, Tsutomu Omatsu, Yupadee Hengjan, Tetsuya Mizutani, Yasushige Ohmori, Eiichi Hondo
BACKGROUND: The opening and closing of the implantation window is important for successful pregnancy in eutherians. The recent study demonstrated that the window of uterine receptivity was prepared by the sole action of progesterone in mice, but the mechanism to close the window remained to be elucidated. METHODS: The pregnant mice were ovariectomized on the evening on the third day of pregnancy with a single injection of medroxyprogesterone acetate to induce delayed implantation (DI)...
April 2017: Journal of Reproduction & Infertility
https://read.qxmd.com/read/28736738/preserving-and-restoring-bone-with-continuous-insulin-infusion-therapy-in-a-mouse-model-of-type-1-diabetes
#30
JOURNAL ARTICLE
Jeffry S Nyman, Evangelia Kalaitzoglou, R Clay Bunn, Sasidhar Uppuganti, Kathryn M Thrailkill, John L Fowlkes
Those with type 1 diabetes (T1D) are more likely to suffer a fracture than age- and sex-matched individuals without diabetes, despite daily insulin therapy. In rodent studies examining the effect of bone- or glucose-targeting therapies on preventing the T1D-related decrease in bone strength, insulin co-therapy is often not included, despite the known importance of insulin signaling to bone mass accrual. Therefore, working toward a relevant pre-clinical model of diabetic bone disease, we assessed the effect of continuous subcutaneous insulin infusion (CSII) therapy at escalating doses on preserving bone and the effect of delayed CSII on rescuing the T1D-related bone deterioration in an established murine model of T1D...
December 2017: Bone Reports
https://read.qxmd.com/read/28143857/chronic-hyperinsulinemia-contributes-to-insulin-resistance-under-dietary-restriction-in-association-with-altered-lipid-metabolism-in-zucker-diabetic-fatty-rats
#31
JOURNAL ARTICLE
Ippei Morita, Keiichi Tanimoto, Nobuteru Akiyama, Noriyuki Naya, Kumiko Fujieda, Takanori Iwasaki, Hideo Yukioka
Hyperinsulinemia is widely thought to be a compensatory response to insulin resistance, whereas its potentially causal role in the progression of insulin resistance remains to be established. Here, we aimed to examine whether hyperinsulinemia could affect the progression of insulin resistance in Zucker fatty diabetic (ZDF) rats. Male ZDF rats at 8 wk of age were fed a diet ad libitum (AL) or dietary restriction (DR) of either 15 or 30% from AL feeding over 6 wk. Insulin sensitivity was determined by hyperinsulinemic euglycemic clamp...
April 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/27696668/the-impact-of-endobarrier-gastrointestinal-liner-in-obese-patients-with-normal-glucose-tolerance-and-in-patients-with-type-2-diabetes
#32
JOURNAL ARTICLE
Ulrich Rohde, Cecilie A Federspiel, Peter Vilmann, Ebbe Langholz, Steffen U Friis, Martin Krakauer, Jens F Rehfeld, Jens J Holst, Tina Vilsbøll, Filip K Knop
AIMS: The duodenal-jejunal bypass sleeve ((DJBS) or EndoBarrier Gastrointestinal Liner) induces weight loss in obese subjects and may improve glucose homeostasis in patients with type 2 diabetes (T2D). To explore the underlying mechanisms, we evaluated postprandial physiology including glucose metabolism, gut hormone secretion, gallbladder emptying, appetite and food intake in patients undergoing DJBS treatment. MATERIAL AND METHODS: A total of 10 normal glucose-tolerant (NGT) obese subjects and 9 age-, body weight- and body mass index-matched metformin-treated T2D patients underwent a liquid mixed meal test and a subsequent ad libitum meal test before implantation with DJBS and 1 week (1w) and 26 weeks (26w) after implantation...
February 2017: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/27007156/the-effects-of-graded-levels-of-calorie-restriction-v-impact-of-short-term-calorie-and-protein-restriction-on-physical-activity-in-the-c57bl-6-mouse
#33
JOURNAL ARTICLE
Sharon E Mitchell, Camille Delville, Penelope Konstantopedos, Davina Derous, Cara L Green, Yingchun Wang, Jing-Dong J Han, Daniel E L Promislow, Alex Douglas, Luonan Chen, David Lusseau, John R Speakman
Calorie restriction (CR) delays the onset of age-related disease and extends lifespan in a number of species. When faced with reduced energy supply animals need to lower energy demands, which may be achieved in part by reducing physical activity (PA). We monitored changes in PA using implanted transmitters in male C57BL/6 mice in response to graded levels of CR (10 to 40%) or matched levels of graded protein restriction (PR) for 3 months. Mice were fed at lights out and ad libitum controls were limited to dark-phase feeding (12AL) or 24hr/day...
April 12, 2016: Oncotarget
https://read.qxmd.com/read/26817629/vitamin-d-mitigates-the-adverse-effects-of-obesity-on-breast-cancer-in-mice
#34
JOURNAL ARTICLE
Srilatha Swami, Aruna V Krishnan, Jasmaine Williams, Abhishek Aggarwal, Megan A Albertelli, Ronald L Horst, Brian J Feldman, David Feldman
Obesity is an established risk factor for postmenopausal breast cancer (BCa), insulin resistance, and vitamin D deficiency, and all contribute to increased synthesis of mammary estrogens, the drivers of estrogen receptor-positive (ER+) BCa growth. As both dietary vitamin D and calcitriol treatments inhibit breast estrogen synthesis and signaling, we hypothesized that vitamin D would be especially beneficial in mitigating the adverse effects of obesity on ER+BCa. To assess whether obesity exerted adverse effects on BCa growth and whether vitamin D compounds could reduce these unfavorable effects, we employed a diet-induced obesity (DIO) model in ovariectomized C57BL/6 mice...
April 2016: Endocrine-related Cancer
https://read.qxmd.com/read/26678364/daytime-blue-light-enhances-the-nighttime-circadian-melatonin-inhibition-of-human-prostate-cancer-growth
#35
JOURNAL ARTICLE
Robert T Dauchy, Aaron E Hoffman, Melissa A Wren-Dail, John P Hanifin, Benjamin Warfield, George C Brainard, Shulin Xiang, Lin Yuan, Steven M Hill, Victoria P Belancio, Erin M Dauchy, Kara Smith, David E Blask
Light controls pineal melatonin production and temporally coordinates circadian rhythms of metabolism and physiology in normal and neoplastic tissues. We previously showed that peak circulating nocturnal melatonin levels were 7-fold higher after daytime spectral transmittance of white light through blue-tinted (compared with clear) rodent cages. Here, we tested the hypothesis that daytime blue-light amplification of nocturnal melatonin enhances the inhibition of metabolism, signaling activity, and growth of prostate cancer xenografts...
December 2015: Comparative Medicine
https://read.qxmd.com/read/26308506/diabetes-is-reversed-in-a-murine-model-by-marginal-mass-syngeneic-islet-transplantation-using-a-subcutaneous-cell-pouch-device
#36
JOURNAL ARTICLE
Andrew R Pepper, Rena Pawlick, Boris Gala-Lopez, Amanda MacGillivary, Delfina M Mazzuca, David J G White, Philip M Toleikis, A M James Shapiro
BACKGROUND: Islet transplantation is a successful β-cell replacement therapy for selected patients with type 1 diabetes mellitus. Although high rates of early insulin independence are achieved routinely, long-term function wanes over time. Intraportal transplantation is associated with procedural risks, requires multiple donors, and does not afford routine biopsy. Stem cell technologies may require potential for retrievability, and graft removal by hepatectomy is impractical. There is a clear clinical need for an alternative, optimized transplantation site...
November 2015: Transplantation
https://read.qxmd.com/read/26135741/chronic-dietary-administration-of-the-glycolytic-inhibitor-2-deoxy-d-glucose-2-dg-inhibits-the-growth-of-implanted-ehrlich-s-ascites-tumor-in-mice
#37
JOURNAL ARTICLE
Saurabh Singh, Sanjay Pandey, Anant Narayan Bhatt, Richa Chaudhary, Vikas Bhuria, Namita Kalra, Ravi Soni, Bal Gangadhar Roy, Daman Saluja, Bilikere S Dwarakanath
BACKGROUND: Dietary energy restriction (DER) has been well established as a potent anticancer strategy. Non-adoption of restricted diet for an extended period has limited its practical implementation in humans with a compelling need to develop agents that mimic effects similar to DER, without reduction in actual dietary intake. Glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), has recently been shown to possess potential as an energy restriction mimetic agent (ERMA). In the present study we evaluated the effect of dietary 2-DG administration on a mouse tumor model, with a focus on several potential mechanisms that may account for the inhibition of tumorigenesis...
2015: PloS One
https://read.qxmd.com/read/25493642/dose-dependent-ampk-dependent-and-independent-mechanisms-of-berberine-and-metformin-inhibition-of-mtorc1-erk-dna-synthesis-and-proliferation-in-pancreatic-cancer-cells
#38
JOURNAL ARTICLE
Ming Ming, James Sinnett-Smith, Jia Wang, Heloisa P Soares, Steven H Young, Guido Eibl, Enrique Rozengurt
Natural products represent a rich reservoir of potential small chemical molecules exhibiting anti-proliferative and chemopreventive properties. Here, we show that treatment of pancreatic ductal adenocarcinoma (PDAC) cells (PANC-1, MiaPaCa-2) with the isoquinoline alkaloid berberine (0.3-6 µM) inhibited DNA synthesis and proliferation of these cells and delay the progression of their cell cycle in G1. Berberine treatment also reduced (by 70%) the growth of MiaPaCa-2 cell growth when implanted into the flanks of nu/nu mice...
2014: PloS One
https://read.qxmd.com/read/25080048/a-pharmacokinetic-model-of-a-tissue-implantable-insulin-sensor
#39
JOURNAL ARTICLE
Gili Bisker, Nicole M Iverson, Jiyoung Ahn, Michael S Strano
While implantable sensors such as the continuous glucose monitoring system have been widely studied, both experimentally and mathematically, relatively little attention has been applied to the potential of insulin sensors. Such sensors can provide feedback control for insulin infusion systems and pumps and provide platforms for the monitoring of other biomarkers in vivo. In this work, the first pharmacokinetic model of an affinity sensor is developed for insulin operating subcutaneously in the limit of where mass transfer across biological membranes reaches a steady state...
January 7, 2015: Advanced Healthcare Materials
https://read.qxmd.com/read/24982192/device-design-and-materials-optimization-of-conformal-coating-for-islets-of-langerhans
#40
JOURNAL ARTICLE
Alice A Tomei, Vita Manzoli, Christopher A Fraker, Jaime Giraldo, Diana Velluto, Mejdi Najjar, Antonello Pileggi, R Damaris Molano, Camillo Ricordi, Cherie L Stabler, Jeffrey A Hubbell
Encapsulation of islets of Langerhans may represent a way to transplant islets in the absence of immunosuppression. Traditional methods for encapsulation lead to diffusional limitations imposed by the size of the capsules (600-1,000 μm in diameter), which results in core hypoxia and delayed insulin secretion in response to glucose. Moreover, the large volume of encapsulated cells does not allow implantation in sites that might be more favorable to islet cell engraftment. To address these issues, we have developed an encapsulation method that allows conformal coating of islets through microfluidics and minimizes capsule size and graft volume...
July 22, 2014: Proceedings of the National Academy of Sciences of the United States of America
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