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https://www.readbyqxmd.com/read/28814959/poor-sleep-is-highly-associated-with-house-dust-mite-allergic-rhinitis-in-adults-and-children
#1
Damien Leger, Bénédicte Bonnefoy, Bernard Pigearias, Bertrand de La Giclais, Antoine Chartier
BACKGROUND: Sleep disorders are often underreported to physicians by patients with allergies. This study aimed to characterize the sleep disorders associated with respiratory allergy to house dust mites (HDM) at the time of initiation of sublingual allergen immunotherapy (SLIT) in routine clinical practice. METHODS: This prospective, cross-sectional, observational study was conducted between November 2014 and March 2015 at 189 French trial sites and included 1750 participants suffering from HDM allergy who were initiating SLIT...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28814605/adam10-mediated-icos-ligand-shedding-on-b-cells-is-necessary-for-proper-t-cell-icos-regulation-and-t-follicular-helper-responses
#2
Joseph C Lownik, Andrea J Luker, Sheela R Damle, Lauren Folgosa Cooley, Riham El Sayed, Andreas Hutloff, Costantino Pitzalis, Rebecca K Martin, Mohey Eldin M El Shikh, Daniel H Conrad
The proper regulation of ICOS and ICOS ligand (ICOSL) has been shown to be essential for maintaining proper immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant Ab production resembling lupus. How ICOSL is regulated in response to ICOS interaction is still unclear. We demonstrate that a disintegrin and metalloproteinase (ADAM)10 is the primary physiological sheddase of ICOSL in mice and humans. Using an in vivo system in which ADAM10 is deleted only on B cells, elevated levels of ICOSL were seen...
August 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28814357/association-of-aeroallergen-sensitization-and-atopic-disease-in-the-sonoran-desert
#3
Ryan D Buckley, Tara F Carr
BACKGROUND: Numerous aeroallergens have been associated with the development of asthma, including Alternaria, house-dust mite, and pet dander. Tucson, Arizona, is located in the Sonoran Desert, which has the highest diversity of vegetation of any desert in the world. Given the unique pollen profile in this region, we sought to identify the most common aeroallergens associated with rhinitis and asthma diagnosis in the local adult population. OBJECTIVE: To identify the prevalence of aeroallergen sensitivity in the Tucson adult population and to identify which aeroallergens are associated with a diagnosis of asthma...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814355/der-p-1-and-der-p-2-specific-immunoglobulin-e-measurement-for-diagnosis-of-dermatophagoides-pteronyssinus-allergy-a-systematic-review-and-meta-analysis
#4
Man Tian, Ying Zhou, Wenxin Zhang, Yubao Cui
BACKGROUND: A clinical history of allergic symptoms and a skin-prick test with house-dust mite crude extracts are standard diagnostic procedures for Dermatophagoides pteronyssinus allergy. Specific immunoglobulin E (IgE) responses to Der p 1 and Der p 2 allergens have been used for the diagnosis of D. pteronyssinus allergy; however, evaluation of the diagnostic performance of Der p 1 and Der p 2 specific IgE (sIgE) produced inconsistent findings. We sought to evaluate the diagnostic accuracy of Der p 1 sIgE and Der p 2 sIgE measurement in the diagnosis of D...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28811323/il-22-induces-reg3%C3%AE-and-inhibits-allergic-inflammation-in-house-dust-mite-induced-asthma-models
#5
Takashi Ito, Koichi Hirose, Aiko Saku, Kenta Kono, Hiroaki Takatori, Tomohiro Tamachi, Yoshiyuki Goto, Jean-Christophe Renauld, Hiroshi Kiyono, Hiroshi Nakajima
Previous studies have shown that IL-22, one of the Th17 cell-related cytokines, plays multiple roles in regulating allergic airway inflammation caused by antigen-specific Th2 cells; however, the underlying mechanism remains unclear. Here, we show that allergic airway inflammation and Th2 and Th17 cytokine production upon intratracheal administration of house dust mite (HDM) extract, a representative allergen, were exacerbated in IL-22-deficient mice. We also found that IL-22 induces Reg3γ production from lung epithelial cells through STAT3 activation and that neutralization of Reg3γ significantly exacerbates HDM-induced eosinophilic airway inflammation and Th2 cytokine induction...
August 15, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28806766/sublingual-immunotherapy-slit-for-house-dust-mites-does-not-prevent-new-allergen-sensitization-and-bronchial-hyper-responsiveness-in-allergic-rhinitis-children
#6
Jae Hyun Lim, Jin Youp Kim, Doo Hee Han, Chul Hee Lee, Seung-No Hong, Jee Hye Wee, Sue K Park, Chae-Seo Rhee
INTRODUCTION: The aim of this study is to identify the effects of sublingual immunotherapy (SLIT) on immunologic parameters and bronchial-hyper-responsiveness in children with allergic rhinitis to house-dust mite (HDM), through long-term follow-up cohort. METHODS: Among the Allergic Rhinitis Cohort Study for Kids, pediatric patients who visited the hospital for rhinitis symptoms and proven allergy to HDM through skin prick test were studied. In this cohort, 37 patients received SLIT more than 3-years (SLIT group), and 184 patients received only pharmacologic therapy (non-SLIT group) were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28798186/draft-genome-sequence-of-dermatophagoides-pteronyssinus-the-european-house-dust-mite
#7
Rose Waldron, Jamie McGowan, Natasha Gordon, Charley McCarthy, E Bruce Mitchell, Sean Doyle, David A Fitzpatrick
Dermatophagoides pteronyssinus is the European dust mite and a major source of human allergens. Here, we present the first draft genome sequence of the mite, as well as the ab initio gene prediction and functional analyses that will facilitate comparative genomic analyses with other mite species.
August 10, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28792152/prevalence-and-clinical-characteristics-of-local-allergic-rhinitis-to-house-dust-mites
#8
Chang Gyu Jung, Ji Ho Lee, Ga Young Ban, Hae Sim Park, Yoo Seob Shin
Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy. The aim of this study was to evaluate the prevalence and clinical characteristics of LAR in Korean rhinitis patients compared to allergic rhinitis (AR) and non-allergic rhinitis (NAR). A total of 304 rhinitis patients were enrolled from November 2014 to March 2016. A skin prick test, serum total and specific immunoglobulin E, and a nasal provocation test (NPT) with house dust mite (HDM) were performed on all patients...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28783701/ppar-%C3%AE-promotes-type-2-immune-responses-in-allergy-and-nematode-infection
#9
Ting Chen, Christopher A Tibbitt, Xiaogang Feng, Julian M Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K Sedimbi, Mikael C I Karlsson, Bart N Lambrecht, Gunilla B Karlsson Hedestam, Rudi W Hendriks, Benedict J Chambers, Susanne Nylén, Jonathan M Coquet
A hallmark of immunity to worm infections and many allergies is a strong type 2 immune response. This is characterized by the production of cytokines interleukin-5 (IL-5) and IL-13 by adaptive T helper 2 (TH2) cells and/or type 2 innate lymphoid cells. Peroxisome proliferator activated receptor-γ (PPAR-γ) is typically regarded as an anti-inflammatory factor. We report that TH2 cells express high levels of PPAR-γ in response to the allergen house dust mite and after infection with the parasite Heligmosomoides polygyrus Mice lacking PPAR-γ in T cells failed to effectively differentiate into IL-5- and IL-13-secreting cells and, hence, did not develop TH2 cell-associated pathologies, including goblet cell metaplasia and eosinophilia, in response to allergen challenge...
March 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/28783682/myosin-light-chains-9-and-12-are-functional-ligands-for-cd69-that-regulate-airway-inflammation
#10
Koji Hayashizaki, Motoko Y Kimura, Koji Tokoyoda, Hiroyuki Hosokawa, Kenta Shinoda, Kiyoshi Hirahara, Tomomi Ichikawa, Atsushi Onodera, Asami Hanazawa, Chiaki Iwamura, Jungo Kakuta, Kenzo Muramoto, Shinichiro Motohashi, Damon J Tumes, Tomohisa Iinuma, Heizaburo Yamamoto, Yuzuru Ikehara, Yoshitaka Okamoto, Toshinori Nakayama
Recent decades have witnessed a rapid worldwide increase in chronic inflammatory disorders such as asthma. CD4(+) T helper 2 cells play critical roles in the pathogenesis of allergic airway inflammation, and CD69 expression on activated CD4 T cells is required to induce allergic inflammation in tissues. However, how CD69 mechanistically controls allergic inflammation remains poorly defined. In lymphoid tissues, CD69 regulates cellular retention through inhibition of S1P1 expression and requires no specific ligands to function...
September 16, 2016: Science Immunology
https://www.readbyqxmd.com/read/28776792/a-pilot-study-of-the-effect-of-pullulan-conjugated-der-f-2-allergen-specific-immunotherapy-on-canine-atopic-dermatitis
#11
Kouji Kawano, Takuya Mizuno
BACKGROUND: Dermatophagoides farinae is a major and common environmental house dust mite involved in canine atopic dermatitis (CAD). A formulation of recombinant protein Der f 2 is available in Japan for immunotherapy in dogs. HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of a recombinant allergen based on Der f 2-pullulan for the treatment of cAD. METHODS: Dogs (n = 15) with atopic dermatitis were administered Der f 2 conjugated with pullulan (-P)...
August 4, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28768771/activation-of-mas-related-g-protein-coupled-receptors-by-the-house-dust-mite-cysteine-protease-der-p1-provides-a-new-mechanism-linking-allergy-and-inflammation
#12
Vemuri B Reddy, Ethan A Lerner
Cysteine and serine proteases function via protease-activated (PARs) and mas-related G-protein coupled receptors (Mrgprs) to contribute to allergy and inflammation. Der p1 is a cysteine protease and major allergen from the house dust mite and is associated with allergic rhinitis and allergic asthma. Der p1 activates PAR2 and induces the release of the pro-inflammatory cytokine IL-6 from cells. However, the possibility that Der p1 acts on Mrgprs has not been considered. We report here that ratiometric calcium imaging reveals that Der p1 activates the human receptor MRGPRX1 and the mouse homolog MrgprC11, implicated previously in itch...
August 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28765824/is-nonhomogeneous-expression-of-tissue-mast-cells-or-allergen-specific-iges-bound-to-tissue-mast-cells-possible
#13
Murat Türk, Sakine Nazik Bahçecioğlu, İnsu Yılmaz
Skin prick tests (SPTs) are widely used to demonstrate an IgE-mediated hypersensitivity reaction to a specific allergen. However, local allergic conditions cannot be diagnosed with SPTs. Local specific IgE production was only presented before in mucosal tissues. We present a patient with house dust mite sensitization that had variable SPTs results in different body regions.
July 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28763131/the-effect-of-allergen-induced-bronchoconstriction-on-concentration-of-5-oxo-ete-in-exhaled-breath-condensate-of-house-dust-mite-allergic-patients
#14
Krzysztof Kowal, Anna Gielicz, Marek Sanak
BACKGROUND: Arachidonic acid metabolites regulate several aspects of airway function including inflammation, muscle contraction and mucous secretion. OBJECTIVE: The aim of this study was to evaluate concentration of selected 5-lipoxygenase (LOX) and cyclooxygenase (COX)-derived eicosanoids in exhaled breath condensate (EBC) during allergen induced bronchoconstriction. METHODS: The study was performed on 24 allergic rhinitis/asthma patients sensitized to a house dust mite (HDM) Dermatophagoides pteronyssinus (Dp) and 13 healthy controls (HCs)...
August 1, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28761286/house-dust-mite-sensitization-is-inversely-associated-with-plasma-25-hydroxyvitamin-d3-levels-in-patients-with-severe-atopic-dermatitis
#15
Yong Hyun Jang, Hyun Bo Sim, Sun Young Moon, Weon Ju Lee, Seok-Jong Lee, Meiling Jin, Sang-Hyun Kim, Do Won Kim
BACKGROUND: The relationship between atopic dermatitis (AD) and low vitamin D levels has been studied. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. However, the effect of vitamin D on house dust mite (HDM) sensitization in patients with AD has not been established. OBJECTIVE: We investigated the association between vitamin D levels and HDM sensitization according to AD severity...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28759611/tpl-2-restricts-ccl24-dependent-immunity-to-heligmosomoides-polygyrus
#16
Yashaswini Kannan, Lewis J Entwistle, Victoria S Pelly, Jimena Perez-Lloret, Alan W Walker, Steven C Ley, Mark S Wilson
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We recently demonstrated TPL-2 reduces severe airway allergy to house dust mite by negatively regulating type-2 responses. In the present study, we found that TPL-2 deficiency resulted in resistance to Heligmosomoides polygyrus infection, with accelerated worm expulsion, reduced fecal egg burden and reduced worm fitness...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28741705/house-dust-mites-as-potential-carriers-for-ige-sensitisation-to-bacterial-antigens
#17
Sheron Dzoro, Irene Mittermann, Yvonne Resch, Susanne Vrtala, Marion Nehr, Alexander M Hirschl, Gustav Wikberg, Lena Lundeberg, Catharina Johansson, Annika Scheynius, Rudolf Valenta
BACKGROUND: IgE-reactivity to antigens from gram-positive and negative bacteria is common in patients suffering from respiratory and skin manifestations of allergy, but the routes and mechanisms of sensitisation are not fully understood. The analysis of the genome, transcriptome and microbiome of house dust mites (HDM) has shown that S. aureus and E. coli species are abundant bacteria within the HDM microbiome. Therefore, our aim was to investigate if HDM are carriers of bacterial antigens leading to IgE sensitisation in patients suffering from atopic dermatitis...
July 25, 2017: Allergy
https://www.readbyqxmd.com/read/28740493/impact-of-enhancer-of-zeste-homolog-2-on-t-helper-cell-mediated-allergic-rhinitis
#18
Tsung-Yun Hou, Ming-Rong Chen, Yu-Ching Chou, Po-Chieh Kan, Yi-Ta Tsai, Tai-Lung Cha
Enhancer of zeste homolog 2 (Ezh2) has been shown to play a role in the differentiation of T helper (Th) 1 and 2 cells in mice studies using Ezh2-deficient T cells. However, the results have been inconsistent, and the function of Ezh2 in human Th1 and Th2 cell differentiation and its association with disease remains controversial. We measured the expression of Ezh2 in Th1 and Th2 cells in peripheral blood mononuclear cells after acute challenge with house dust mite using flow cytometry in patients with allergic rhinitis (AR) and controls...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28740386/quantum-dots-based-lateral-flow-immunoassay-combined-with-image-analysis-for-semiquantitative-detection-of-ige-antibody-to-mite
#19
Yan Zhao, Qiang Zhang, Qingfeng Meng, Fenglian Wu, Lihua Zhang, Yao Tang, Yuanyuan Guan, Lixin An
Semiquantitative and rapid detection of specific IgE (sIgE) with well clinical relevance to house dust mite (HDM) are promising for prevalence rhinitis and asthma patients due to the increasing air pollution. However, the conventional IgE measurement systems are time-consuming, complicated and require special instruments. Herein, we overcome the above limitations of sIgE to HDM detection system by developing a quantum dot nanobeads-based lateral flow immunoassay and an image analysis procedure. The proposed detection system could semiquantitatively measure the IgE in a linear range of 0...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28732432/intradermal-skin-testing-in-allergic-rhinitis-and-asthma-with-negative-skin-prick-tests
#20
Fuat Erel, Nurhan Sarioglu, Mehmet Kose, Mustafa Kaymakci, Mucahide Gokcen, Ahmet Hamdi Kepekci, Mehmet Arslan
Taking medical history, physical examination, and performing some in vivo and in vitro tests are necessary for the diagnosis of allergy. Skin prick test (SPT) is considered as the standard method and first-line approach for the detection of allergic sensitization. Although mainly SPT is used for the detection of allergic sensitization, intradermal skin test (IDST) may be necessary, especially in patients with a negative SPT result. IDST is quite safe; however, is nowadays seldom used for detection of inhalant allergy and its value remains controversial...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
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