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https://www.readbyqxmd.com/read/29932732/how-clean-is-your-house-a-study-of-house-dust-mites-allergens-and-other-contents-of-dust-samples-collected-from-households
#1
Lucy S Casley, Tom Godec, James G Logan, James C Pearce, Hugh M P Smith, Sophie A Stewart, Sarah Y Dewhirst
Household dust contains an array of constituents, including house dust mites (HDM) and the HDM allergen, Der p 1, which can cause sensitivities such as asthma and eczema. Vacuuming can help alleviate symptoms, yet little is understood about cleaning behaviour in different households. This pilot study investigated the contents of dust from four household types (students; over 65 s; and families with and without pets). This was then related to cleaning behaviours and perceptions of cleanliness. Our investigation found that HDMs and Der p 1 were present in all households and sampling locations, including participants' cars...
June 22, 2018: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/29922162/multi-walled-carbon-nanotubes-augment-allergic-airway-eosinophilic-inflammation-by-promoting-cysteinyl-leukotriene-production
#2
Sophia Carvalho, Maria Ferrini, Lou Herritt, Andrij Holian, Zeina Jaffar, Kevan Roberts
Multi-walled carbon nanotubes (MWCNT) have been reported to promote lung inflammation and fibrosis. The commercial demand for nanoparticle-based materials has expanded rapidly and as demand for nanomaterials grows, so does the urgency of establishing an appreciation of the degree of health risk associated with their increased production and exposure. In this study, we examined whether MWCNT inhalation elicited pulmonary eosinophilic inflammation and influenced the development of allergic airway inflammatory responses...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29921463/sublingual-immunotherapy-of-house-dust-mite-respiratory-allergy-in-china
#3
REVIEW
L Cheng, W-C Zhou
Sublingual immunotherapy (SLIT) has been widely used for the treatment of allergic respiratory diseases, but many problems remain unsolved. Currently available data suggest that SLIT is very effective in children and adults with IgE-mediated respiratory diseases. Most allergists in China generally believe that SLIT is suitable for allergic rhinitis and asthma due to its safety and tolerability. SLIT for three years is suitable for patients to acquire stable therapeutic effects, and the efficacy of single-allergen SLIT for polysensitized patients has also been confirmed...
June 16, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29911993/endothelial-cells-in-the-innate-response-to-allergens-and-initiation-of-atopic-asthma
#4
Kewal Asosingh, Kelly Weiss, Kimberly Queisser, Nicholas Wanner, Mei Yin, Mark Aronica, Serpil Erzurum
Protease-activated receptor 2 (PAR-2), an airway epithelial pattern recognition receptor (PRR), participates in the genesis of house dust mite-induced (HDM-induced) asthma. Here, we hypothesized that lung endothelial cells and proangiogenic hematopoietic progenitor cells (PACs) that express high levels of PAR-2 contribute to the initiation of atopic asthma. HDM extract (HDME) protease allergens were found deep in the airway mucosa and breaching the endothelial barrier. Lung endothelial cells and PACs released the Th2-promoting cytokines IL-1α and GM-CSF in response to HDME, and the endothelium had PAC-derived VEGF-C-dependent blood vessel sprouting...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29911320/an-open-study-on-the-efficacy-of-a-recombinant-der-f-2-dermatophagoides-farinae-immunotherapy-in-atopic-dogs-in-hungary-and-switzerland
#5
Nina Fischer, Noémi Tarpataki, Federica Leidi, Ana Rostaher, Claude Favrot
BACKGROUND: Previously published studies evaluating a recombinant Der f 2-based immunotherapy have demonstrated efficacy in the treatment of dogs experimentally and naturally sensitized to house dust mites (HDM). Der f 2 sensitization is thought to play a minor role in European atopic dogs sensitized to HDM. OBJECTIVE: The study evaluated the short-term efficacy of a recombinant Der f 2 product in the treatment of naturally sensitized atopic dogs in Switzerland and Hungary...
June 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29910811/il-4-is-a-key-requirement-for-il-4-and-il-4-il-13-expressing-cd4-th2-subsets-in-lung-and-skin
#6
Melanie Sarah Prout, Ryan L Kyle, Franca Ronchese, Graham Le Gros
Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4's role in CD4 Th2 responses by using transgenic mice that express a dual IL-4 AmCyan/IL-13 DsRed (IL-4AC/IL-13DR) fluorescent reporter on an IL-4-sufficient or IL-4-deficient background. Using primary Th2 immune response models against house dust mite or Nippostrongylus brasiliensis ( Nb ) allergens, we examined the requirement for IL-4 by each of the defined Th2 subsets in the antigen draining lymph node, skin, and lung tissues...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29906529/the-emerging-roles-of-the-protease-allergen-der-p-1-in-house-dust-mite-induced-airway-inflammation
#7
EDITORIAL
Andy Chevigne, Alain Jacquet
No abstract text is available yet for this article.
June 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29900561/rage-dependent-vcam-1-expression-in-the-lung-endothelium-mediates-il-33-induced-allergic-airway-inflammation
#8
Timothy N Perkins, Elizabeth A Oczypok, Pavle S Milutinovic, Regina E Dutz, Tim D Oury
BACKGROUND: The receptor for advanced glycation endproducts (RAGE) has been implicated as a critical molecule in the pathogenesis of experimental asthma/allergic airway inflammation (AAI). It has been previously shown that RAGE acts both upstream of interleukin-33 (IL-33) release and downstream of IL-33 release via RAGE-dependent IL-33 induced accumulation of type 2 innate lymphoid cells (ILC2s) in the lungs, which perpetuate type 2 inflammation and mucus metaplasia. However, the mechanism by which RAGE mediates downstream IL-33 induced type 2 inflammatory responses is unknown...
June 14, 2018: Allergy
https://www.readbyqxmd.com/read/29899324/atopic-dermatitis-like-skin-lesions-are-suppressed-in-fat-1-transgenic-mice-through-the-inhibition-of-inflammasomes
#9
Hyun-Young Jang, Jeung-Hyun Koo, Sang-Myeong Lee, Byung-Hyun Park
Previous clinical trials have addressed the beneficial effects of fish oil supplementation on atopic dermatitis. Recently, we reported that fat-1 mice, which can convert n-6 to n-3 polyunsaturated fatty acids (PUFAs), are protected against allergic airway inflammation because their Th2 immune responses are suppressed. Here, we examined the effects of endogenously synthesized n-3 PUFAs on atopic dermatitis, a representative Th2-dominant allergic inflammatory disease. Mouse models of atopic dermatitis-like skin lesions were prepared by epicutaneous application of 2,4-dinitrochlorobenzene (DNCB) or house dust mite (HDM) extract to the ears...
June 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29890236/a-bispecific-antibody-strategy-to-target-multiple-type-2-cytokines-in-asthma
#10
Marie Godar, Kim Deswarte, Karl Vergote, Michael Saunders, Hans de Haard, Hamida Hammad, Christophe Blanchetot, Bart N Lambrecht
BACKGROUND: Asthma is a chronic inflammatory airway disease in which innate and adaptive immune cells act together to cause eosinophilic inflammation, goblet cell metaplasia (GCM) and bronchial hyperreactivity (BHR). In clinical trials employing biologicals against interleukin (IL)-4Rα or IL-5, only a subset of moderate-to-severe asthmatics responded favorably, suggesting that distinct pathophysiological mechanisms are at play in subgroups of patients, called endotypes. However, the effect of multiple cytokine blockade using bispecific antibodies (Ab) has not been tested...
June 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29885866/leptin-osteopontin-axis-regulated-type-2t-helper-cell-response-in-allergic-rhinitis-with-obesity
#11
Qingxiang Zeng, Xi Luo, Miaomiao Han, Wenlong Liu, Huabin Li
The prevalence of allergic rhinitis (AR) and obesity in children increased concurrently during recent decades. However, the molecular pathway involved in the interaction between obesity and AR is still unclear. We aimed to investigate the interaction between leptin and osteopontin (OPN) and their effect on T helper (TH ) response in the development of AR in children. Thirty AR and 30 healthy children with or without obesity were enrolled. Serum leptin and OPN levels were measured and their relationship with TH 1/2 cytokines was analyzed...
June 6, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29885036/role-of-sublingual-immunotherapy-in-the-treatment-of-asthma-an-updated-systematic-review
#12
Sandra Y Lin, Antoine Azar, Catalina Suarez-Cuervo, Gregory B Diette, Emily Brigham, Jessica Rice, Murugappan Ramanathan, Karen A Robinson
BACKGROUND: The purpose of the systematic review is to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) for the treatment of allergic asthma. METHODS: PubMed, Embase, and CENTRAL databases were searched, updating an earlier review (January 1, 2005 through May 8, 2017). Randomized, controlled studies (RCTs) were included, which reported one of the prespecified outcomes: asthma symptoms measured by control composite scores; quality of life; medication use; pulmonary physiology; and health-care utilization...
June 9, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29881542/cross-sectional-study-on-sensitization-to-mite-and-cockroach-allergen-components-in-allergy-patients-in-the-central-european-region
#13
Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská, Marek Malý
Background: The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite and cockroach allergens in Central Europe has not been established yet. Methods: We assessed sensitization profiles of allergy patients in a Central European region in regard to sensitization to mites and cockroach...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29881388/eicosapentaenoic-acid-enhances-the-effects-of-mesenchymal-stromal-cell-therapy-in-experimental-allergic-asthma
#14
Soraia Carvalho Abreu, Miquéias Lopes-Pacheco, Adriana Lopes da Silva, Debora Gonçalves Xisto, Tainá Batista de Oliveira, Jamil Zola Kitoko, Lígia Lins de Castro, Natália Recardo Amorim, Vanessa Martins, Luisa H A Silva, Cassiano Felippe Gonçalves-de-Albuquerque, Hugo Caire de Castro Faria-Neto, Priscilla Christina Olsen, Daniel Jay Weiss, Marcelo Marcos Morales, Bruno Lourenço Diaz, Patricia Rieken Macêdo Rocco
Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness. Despite recent advances in the understanding of its pathophysiology, asthma remains a major public health problem and, at present, there are no effective interventions capable of reversing airway remodeling. Mesenchymal stromal cell (MSC)-based therapy mitigates lung inflammation in experimental allergic asthma; however, its ability to reduce airway remodeling is limited. We aimed to investigate whether pre-treatment with eicosapentaenoic acid (EPA) potentiates the therapeutic properties of MSCs in experimental allergic asthma...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29848863/-house-dust-and-its-adverse-health-effects
#15
Atsuko Araki, Yu Ait Bamai, Rahel Mesfin Ketema, Reiko Kishi
In this review, we examine house dust and its effect on inhabitants' health. Residential house dust includes components from plants, pollens, microorganisms, insects, skin flakes, hairs and fibers. It also includes materials contaminated with chemicals from combustion, furniture, interior materials, electronics, cleaning agents, personal care products. Nowadays, most people spend their time indoors. Thus, dust is an important medium of exposure to pollutions. According to United States Environmental Protection Agency Exposure Factors Handbook, the estimated amount of dust ingestion is 30 mg/day for adults, and 60 mg/day for children over 1 year of age...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/29846732/th17-induced-neutrophils-enhance-the-pulmonary-allergic-response-following-balb-c-exposure-to-house-dust-mite-allergen-and-fine-particulate-matter-from-california-and-china
#16
Jingjing Zhang, Ciara C Fulgar, Tiffany Mar, Dominique E Young, Qi Zhang, Keith J Bein, Liangliang Cui, Alejandro Castañeda, Christoph F A Vogel, Xiaolin Sun, Wei Li, Suzette Smiley-Jewell, Zunzhen Zhang, Kent E Pinkerton
Asthma is a global and increasingly prevalent disease. According to the World Health Organization, approximately 235 million people suffer from asthma. Studies suggest that fine particulate matter (PM2.5) can induce innate immune responses, promote allergic sensitization, and exacerbate asthmatic symptoms and airway hyper-responsiveness. Recently, severe asthma and allergic sensitization have been associated with T-helper cell type 17 (TH17) activation. Few studies have investigated the links between PM2.5 exposure, allergic sensitization, asthma, and TH17 activation...
May 28, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29813071/elevated-oxytocin-and-noradrenaline-indicate-higher-stress-levels-in-allergic-rhinitis-patients-implications-for-the-skin-prick-diagnosis-in-a-pilot-study
#17
Jelena Gotovina, Christina L Pranger, Annika N Jensen, Stefanie Wagner, Oswald D Kothgassner, Nadine Mothes-Luksch, Rupert Palme, Desirée Larenas-Linnemann, Jaswinder Singh, Ralph Mösges, Anna Felnhofer, Lisa-Maria Glenk, Erika Jensen-Jarolim
BACKGROUND & AIMS: The effects of acute stress on allergic symptoms are little understood. The intention of this clinical study was to study the effects of acute stress and related mediators in allergic rhinitis (AR), taking the wheal and flare reaction in skin prick testing (SPT) as a readout. METHODS: 19 healthy and 21 AR patients were first subjected to SPTs with grass pollen-, birch pollen- and house dust mite allergen extracts, histamine and negative control...
2018: PloS One
https://www.readbyqxmd.com/read/29806218/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2015-part-2-prevention-and-treatment
#18
REVIEW
A Lloyd-Lavery, N K Rogers, E Davies, D J C Grindlay, K S Thomas
This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 26 systematic reviews that were published during 2015, and focuses on the treatment and prevention of AE. For systematic reviews on the epidemiology and methodological issues, see Part 1 of this update. Topical corticosteroid withdrawal syndrome, 'steroid addiction', has been evaluated in a high-quality systematic review, which helps better define this entity and the risk factors for it...
May 27, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29805413/detection-and-allergen-analysis-of-serum-ige-in-pediatric-patients-with-chronic-urticaria
#19
Yi Zhou, Minmin Sheng, Mingyan Chen
Objective: To detect the serum IgE and allergen-specific IgE levels of pediatric patients with chronic urticaria, and to analyze the distribution characteristics of allergens. Methods: Ninety-six patients with chronic urticaria admitted in our hospital, which were not administered antihistamine 10 days before detection or glucocorticoid 20 days before detection, were selected. Their serum IgE levels were measured and 34 antigens were analyzed. Results: Ninety-two of the ninety-six patients were detected as serum IgE positive (positive rate: 95...
March 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29805085/current-status-of-sublingual-immunotherapy-for-allergic-rhinitis-in-japan
#20
REVIEW
Keisuke Masuyama, Tomokazu Matsuoka, Atsushi Kamijo
Japanese cedar pollen (JCP) and house dust mite (HDM) are two major allergens that cause allergic rhinitis (AR) in Japan and the prevalence of AR is increasing. Pharmacothearpy is a commonly used treatment, but the level of patient satisfaction is very low. Allergen immunotherapy (AIT) is the only therapeutic modality that provides not only symptom relief but also quality of life improvement that leads to a high rate of satisfaction. In particular, sublingual immunotherapy (SLIT) is a safe and effective treatment for AR...
May 25, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
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