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https://www.readbyqxmd.com/read/28228560/expression-of-il-22-in-the-skin-causes-th2-biased-immunity-epidermal-barrier-dysfunction-and-pruritus-via-stimulating-epithelial-th2-cytokines-and-the-grp-pathway
#1
Hongfei Lou, Jingning Lu, Eun Byul Choi, Min Hee Oh, Mingeum Jeong, Sara Barmettler, Zhou Zhu, Tao Zheng
Increased expression of Th22 cytokine IL-22 is a characteristic finding in atopic dermatitis (AD). However, the specific role of IL-22 in the pathogenesis of AD in vivo has yet to be elucidated. Consistent with observations in human AD, IL-22 was significantly increased in the AD skin of mice after epicutaneous sensitization to house dust mite allergen. Utilizing a skin-specific inducible transgenic system, we show in the present study that expression of IL-22 in the skin of mice caused an AD-like phenotype characterized by chronic pruritic dermatitis associated with Th2-biased local and systemic immune responses, downregulation of epidermal differentiation complex genes, and enhanced dermatitis upon epicutaneous allergen exposure...
February 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28224996/intelectin-contributes-to-allergen-induced-il-25-il-33-and-tslp-expression-and-type-2-response-in-asthma-and-atopic-dermatitis
#2
L Yi, D Cheng, K Zhang, X Huo, Y Mo, H Shi, H Di, Y Zou, H Zhang, J Zhao, Y Xu, D J Erle, G Zhen
The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD). However, the mechanism by which the expression of these innate cytokines is regulated remains unclear. Intelectin (ITLN) is expressed in airway epithelial cells and promotes allergic airway inflammation. We hypothesized that ITLN is required for allergen-induced IL-25, IL-33, and TSLP expression. In two asthma models, Itln knockdown reduced allergen-induced increases in Il-25, Il-33, and Tslp and development of type 2 response, eosinophilic inflammation, mucus overproduction, and airway hyperresponsiveness...
February 22, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28223739/effectiveness-of-specific-sublingual-immunotherapy-in-korean-patients-with-atopic-dermatitis
#3
Hyang-Suk You, Min-Young Yang, Gun-Wook Kim, Hyun-Ho Cho, Won-Jeong Kim, Je-Ho Mun, Margaret Song, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Sublingual immunotherapy (SLIT) with house dust mites (HDM) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. However, there has been no report regarding the efficacy and safety of SLIT in Korean patients with atopic dermatitis (AD). OBJECTIVE: We intended to investigate the efficacy and safety of SLIT in Korean patients with AD. METHODS: A total of 34 patients with AD and immunoglobulin E (IgE)-proven HDM sensitization (Class ≥3) were recruited...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28219072/human-allergen-specific-igg-subclass-antibodies-measured-using-immunocap-technology
#4
Robert Movérare, Karin Blume, Peter Lind, René Crevel, Åsa Marknell DeWitt, Stella Cochrane
BACKGROUND: Knowledge of human IgG subclass antibody responses to various allergens has been hampered by a lack of reliable standardized assays. The aim here was to develop quantitative immunoassays for human IgG1, IgG2, and IgG3 antibodies using ImmunoCAP® technology and to evaluate their application. METHODS: Enzyme conjugates with isotype-specific monoclonal antibodies and calibrators composed of purified myeloma paraproteins were developed for each assay and used together with other standardized assay reagents for the Phadia® 100 instrument...
February 21, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28218721/bee-venom-phospholipase-a2-ameliorates-house-dust-mite-extract-induced-atopic-dermatitis-like-skin-lesions-in-mice
#5
Kyung-Hwa Jung, Hyunjung Baek, Manho Kang, Namsik Kim, Seung Young Lee, Hyunsu Bae
Atopic dermatitis (AD) is a biphasic inflammatory skin disease that is provoked by epidermal barrier defects, immune dysregulation, and increased skin infections. Previously, we have demonstrated that bvPLA2 evoked immune tolerance by inducing regulatory T cells (Treg), and thus alleviated Th2 dominant allergic asthma in mice. Here, we would like to determine whether treatment with bvPLA2 exacerbates the AD-like allergic inflammations induced by house dust mite extract (DFE) in a murine model. Epidermal thickness, immune cell infiltration, serum immunoglobulin, and cytokines were measured...
February 18, 2017: Toxins
https://www.readbyqxmd.com/read/28207927/attenuated-airway-hyperresponsiveness-and-mucus-secretion-in-hdm-exposed-igf1r-deficient-mice
#6
S Piñeiro-Hermida, J A Gregory, I P López, R Torrens, C Ruíz-Martínez, M Adner, J G Pichel
BACKGROUND: Asthma is a common chronic lung disease characterized by airflow obstruction, airway hyperresponsiveness (AHR) and inflammation. IGFs have been reported to play a role in asthma but little is known about how the Insulin-like Growth Factor 1 Receptor (IGF1R) affects asthma pathobiology. METHODS: Female Igf1r-deficient and control mice were intranasally challenged with house dust mite (HDM) extract or PBS five days per week for four weeks. Lung function measurements, and bronchioalveolar lavage fluid (BALF), serum and lungs were collected on day 28 for further cellular, histological and molecular analysis...
February 16, 2017: Allergy
https://www.readbyqxmd.com/read/28194483/-placebo-effect-in-clinical-trials-with-allergen-specific-immunotherapy-with-inhalant-allergens
#7
B Wedi, D Wieczorek, A Kapp
Placebo effects play an important role in the treatment of allergic diseases. Therefore, in this study, we analysed the described effects of placebo in all double-blind placebo-controlled clinical trials of allergen-specific immunotherapy (ASIT) with inhalant allergens (birch, grass, house dust mites) listed in the tables (updated July 2016) attached to the German S2k guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases. The most common placebo consisted of verum without allergen, but when the subcutaneous route was used, histamine was sometimes added...
February 13, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28192144/maternal-house-dust-mite-exposure-during-pregnancy-enhances-severity-of-hdm-induced-asthma-in-murine-offspring
#8
Phoebe K Richgels, Amnah Yamani, Claire A Chougnet, Ian P Lewkowich
BACKGROUND: Atopic status of the mother and maternal exposure to environmental factors is associated with increased asthma risk. Moreover, animal models demonstrate that exposure to allergens in strongly sensitized mothers influences offspring asthma development, suggesting that in utero exposures can influence offspring asthma. However, it is unclear whether maternal exposure to common human allergens like house dust mite (HDM), in the absence of additional adjuvants, influences offspring asthma development...
February 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28188713/-safety-of-subcutaneous-immunotherapy-with-tyrosine-adsorbed-house-dust-mite-extracts-in-patients-with-allergic-disease
#9
Mónica María Molina-Sáenz, Ana María Villa-Arango, Ricardo Cardona-Villa
BACKGROUND: In spite of allergen-specific immunotherapy (SIT) multiple benefits, its use is restricted in some countries owing to concerns about severe adverse reactions. OBJECTIVE: To evaluate systemic adverse reactions in patients with atopic dermatitis, allergic asthma, allergic rhinitis and allergic conjunctivitis who received subcutaneous immunotherapy with tyrosine-adsorbed Dermatophagoides and Glycyphagoides dust mites extracts. METHODS: Retrospective study of the 2010-2015-period that included 773 patients diagnosed with IgE-mediated diseases, where the safety of allergen-specific immunotherapy was described according to the World Organization of Allergy subcutaneous immunotherapy-induced systemic reactions classification system...
January 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28188710/-prevalence-of-sensitization-to-inhalant-allergens-in-the-immunology-department-from-hospital-de-especialidades-pedi%C3%A3-tricas-mar%C3%A3-a-honduras-2016
#10
Victoria Alejandra Gonzales-González, Adolfo Martín Díaz-Flores, Karla Zobeyda Fernández-Zelaya, María Félix Rivera-Reyes
BACKGROUND: Allergic diseases are a public health problem; estimates indicate that between 30% and 40% of the world population is affected by some allergy. Knowing the prevalence of allergen sensitization allows for adequate diagnoses and treatments to be offered. In Honduras there are no studies available in pediatric patients. OBJECTIVE: The purpose of this research was to identify the most common types of sensitization in children and their correlation with the most common allergic diseases in patients on immunotherapy at the Maria Hospital of Pediatric Specialties...
January 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28181414/a-functional-variant-of-mirna-149-confers-risk-for-allergic-rhinitis-and-comorbid-asthma-in-chinese-children
#11
D Hu, Z Zhang, X Ke, H Kang, S Hong
The prevalence of allergic rhinitis (AR) and asthma has been increasing, and the comorbidity rates of these diseases are very high. Here, 176 AR patients, 124 patients with comorbid AR and asthma (AR-A) and 206 healthy Chinese children as controls were included in a case-control study. Six single-nucleotide polymorphisms (SNPs), miR-146a (rs2910164, rs57095329 and rs6864584), miR-196a2 (rs11614913), miR-499 (rs3746444) and miR-149 (rs2292832), were genotyped. The prevalence of homozygous miR-149 (rs2292832) CC genotype and C allele were considerably increased in AR and AR-A patients, compared with the controls...
February 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28171712/sensitization-to-common-allergens-among-patients-with-allergy-in-major-iranian-cities-a-systemic-review-and-meta-analysis
#12
Mozhgan Moghtaderi, Saeed Hosseini Teshnizi, Shirin Farjadian
Purpose: Various allergens are implicated in the pathogenesis of allergic diseases in different regions. This study attempted to identify the most common allergens among patients with allergy based on results of skin prick tests in different parts of Iran. Methods: Relevant studies were identified from the Medline database from 2000 to 2016. Six common groups of allergens including animals, cockroaches, foods, fungi, house dust mites and pollen were considered. Subgroup analysis was performed to determine prevalence of each type of allergens...
5, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28168947/sublingual-immunotherapy-in-patients-with-house-dust-mite-allergic-rhinitis-prospective-study-of-clinical-outcomes-over-a-two-year-period-corrigendum
#13
J Y Soh, M Thalayasingam, S Ong, E X L Loo, L P Shek, S S Chao
No abstract text is available yet for this article.
February 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28164398/prevalence-of-house-dust-mites-in-the-homes-of-atopic-dogs-in-finland
#14
Kirsti J M Schildt, Riitta T K Seppänen, Anna K Hielm-Björkman, Leena E Saijonmaa-Koulumies, Svetlana Belova
BACKGROUND: The house dust mites (HDM) Dermatophagoides farinae and D. pteronyssinus are important environmental allergens implicated in the pathogenesis of human and canine atopic dermatitis. Sensitization to HDM measured by allergen-specific IgE is common in Finnish atopic dogs. Studies on HDM prevalence in Finland are few but suggest that HDM are scarce. OBJECTIVE: The aim of the present study was to evaluate the prevalence of HDM in the home environments of atopic dogs in Finland...
February 5, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28160515/allergic-asthma-an-overview-of-metabolomic-strategies-leading-to-the-identification-of-biomarkers-in-the-field
#15
Alma Villaseñor, Domenico Rosace, David Obeso, Marina Pérez-Gordo, Tomás Chivato, Coral Barbas, Domingo Barber, María M Escribese
Allergic asthma is a prominent disease especially during childhood. Indoor allergens, in general, and particularly house dust mites (HDM) are the most prevalent sensitizers associated with allergic asthma. Available data shows that 65 to 130 million people are mite-sensitized worldwide and as many as 50% of these are asthmatic. In fact, sensitization to HDM in the first years of life can produce devastating effects on pulmonary function leading to asthmatic syndromes that can be fatal. To date, there has been considerable research into the pathological pathways and structural changes associated with allergic asthma...
February 4, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28151586/nuclear-erythroid-2-related-factor-2-activation-inhibits-house-dust-mite-induced-sinonasal-epithelial-cell-barrier-dysfunction
#16
Nyall R London, Anuj Tharakan, Andrew P Lane, Shyam Biswal, Murugappan Ramanathan
BACKGROUND: Dysregulated sinonasal epithelial cell (SNEC) barrier function has been proposed to contribute to the pathogenesis of sinonasal inflammatory conditions such as allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Allergens such as house dust mite (HDM) have been reported to disrupt SNEC barrier integrity. We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function. The purpose of this study was to explore whether Nrf2 activation could ameliorate HDM-induced SNEC barrier dysfunction...
February 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28137259/effect-of-the-topical-application-of-an-ethanol-extract-of-quince-seeds-on-the-development-of-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#17
Takeshi Kawahara, Kanako Tsutsui, Eri Nakanishi, Toshifumi Inoue, Yasunori Hamauzu
BACKGROUND: Quince (Cydonia oblonga Miller) is a deciduous shrub belonging to the Rosaceae family. Quince seed extract has long been used as a cosmetic ingredient for its moisturizing effect. However, little is known about whether quince seed extract has therapeutic effects on keratinocyte-associated skin inflammation. METHODS: In the present study, we investigated the effect of the topical application of ethanol extract of quince seeds (QSEtE) on atopic dermatitis (AD) symptoms in NC/Nga mice...
January 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28134765/dimerized-translationally-controlled-tumor-protein-binding-peptide-ameliorates-atopic-dermatitis-in-nc-nga-mice
#18
Xing-Hai Jin, Juhyeon Lim, Dong Hae Shin, Jeehye Maeng, Kyunglim Lee
Our previous study showed that dimerized translationally controlled tumor protein (dTCTP) plays a role in the pathogenesis of allergic diseases, such as asthma and allergic rhinitis. A 7-mer peptide, called dTCTP-binding peptide 2 (dTBP2), binds to dTCTP and inhibits its cytokine-like effects. We therefore examined the protective effects of dTBP2 in house dust mite-induced atopic dermatitis (AD)-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice. We found that topical administration of dTBP2 significantly reduced the AD-like skin lesions formation and mast cell infiltration in NC/Nga mice, similarly to the response seen in the Protopic (tacrolimus)-treated group...
January 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28124848/the-prevalence-of-grass-pollen-related-allergic-rhinoconjunctivitis-in-elite-amateur-irish-athletes
#19
M Grace, D Hunt, J O'B Hourihane
Allergic rhinoconjunctivitis (AR/C), has been shown to impact upon athletic performance. The championships of the unique, amateur Irish sports of hurling and Gaelic football (collectively known as GAA) take place during the prime pollen months of summer. Elite GAA players must perform optimally when most exposed to pollen. Elite GAA subjects (n=254) underwent skin prick testing to 6 aeroallergens and completed a validated questionnaire (AQUA), producing a score indicating likelihood of having allergy. The prevalence of allergy (positive to at least one aeroallergen on SPT and positive AQUA score) was 27...
September 9, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28124649/dry-eye-disease-and-allergic-conditions-a-korean-nationwide-population-based-study
#20
Minkyeong Kim, Jong-Hyun Oh, Choul Yong Park, Sang Wha Lee
BACKGROUND: Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface. No epidemiologic reports have yet been published about the relationship between DED and allergic rhinitis or sensitization to allergens. OBJECTIVE: To investigate the association between DED and allergic conditions in the general adult Korean population. METHODS: This population-based cross-sectional study included 17,542 individuals (ages ≥ 19 years) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2012...
November 1, 2016: American Journal of Rhinology & Allergy
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