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https://www.readbyqxmd.com/read/28108561/semaphorin-3e-deficiency-exacerbates-airway-inflammation-hyperresponsiveness-and-remodeling-in-a-mouse-model-of-allergic-asthma
#1
Hesam Movassagh, Lianyu Shan, Ashfaque Mohammed, Andrew J Halayko, Abdelilah S Gounni
Semaphorin 3E (Sema3E) plays a crucial role in axon guidance, vascular patterning, and immune regulation. Nevertheless, the role of Sema3E in asthma is still elusive. In this study, we show that genetic ablation of Sema3E in mice results in increased lung granulocytosis, airway hyperresponsiveness, mucus overproduction, collagen deposition, and Th2/Th17 inflammation. Transfer of Sema3e(-/-) bone marrow progenitor cells to irradiated wild-type (WT) recipients exacerbates airway hyperresponsiveness and inflammation, whereas transfer of WT bone marrow progenitor cells ameliorates asthma pathology in Sema3e(-/-) recipients...
January 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28107552/reflections-on-the-history-of-indoor-air-science-focusing-on-the-last-50-years
#2
Jan Sundell
The scientific articles and Indoor Air conference publications of the indoor air sciences (IAS) during the last 50 years are summarized. In total 7524 presentations, from 79 countries, have been made at Indoor Air conferences held between 1978 (49 presentations) and 2014 (1049 presentations). In the Web of Science 26,992 articles on indoor air research (with the word "indoor" as a search term) have been found (as of 1 Jan 2016) of which 70% were published during the last 10 years. The modern scientific history started in the 1970s with a question: "did indoor air pose a threat to health as did outdoor air?" Soon it was recognized that indoor air is more important, from a health point of view, than outdoor air...
January 20, 2017: Indoor Air
https://www.readbyqxmd.com/read/28107494/protective-roles-for-rgs2-in-a-mouse-model-of-house-dust-mite-induced-airway-inflammation
#3
Tresa George, Matthew Bell, Mainak Chakraborty, David P Siderovski, Mark A Giembycz, Robert Newton
The GTPase-accelerating protein, regulator of G-protein signalling 2 (RGS2) reduces signalling from G-protein-coupled receptors (GPCRs) that signal via Gαq. In humans, RGS2 expression is up-regulated by inhaled corticosteroids (ICSs) and long-acting β2-adrenoceptor agonists (LABAs) such that synergy is produced in combination. This may contribute to the superior clinical efficacy of ICS/LABA therapy in asthma relative to ICS alone. In a murine model of house dust mite (HDM)-induced airways inflammation, three weeks of intranasal HDM (25 μg, 3×/week) reduced lung function and induced granulocytic airways inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28107393/t-cell-subset-and-stimulation-strength-dependent-modulation-of-t-cell-activation-by-kv1-3-blockers
#4
Wai-Ping Fung-Leung, Wilson Edwards, Yi Liu, Karen Ngo, Julianty Angsana, Glenda Castro, Nancy Wu, Xuejun Liu, Ronald V Swanson, Alan D Wickenden
Kv1.3 is a voltage-gated potassium channel expressed on T cells that plays an important role in T cell activation. Previous studies have shown that blocking Kv1.3 channels in human T cells during activation results in reduced calcium entry, cytokine production, and proliferation. The aim of the present study was to further explore the effects of Kv1.3 blockers on the response of different human T cell subsets under various stimulation conditions. Our studies show that, unlike the immune suppressor cyclosporine A, the inhibitory effect of Kv1...
2017: PloS One
https://www.readbyqxmd.com/read/28107345/syk-regulates-neutrophilic-airway-hyper-responsiveness-in-a-chronic-mouse-model-of-allergic-airways-inflammation
#5
Sepehr Salehi, Xiaomin Wang, Stephen Juvet, Jeremy A Scott, Chung-Wai Chow
BACKGROUND: Asthma is a chronic inflammatory disease characterized by airways hyper-responsiveness (AHR), reversible airway obstruction, and airway inflammation and remodeling. We previously showed that Syk modulates methacholine-induced airways contractility in naïve mice and in mice with allergic airways inflammation. We hypothesize that Syk plays a role in the pathogenesis of AHR; this was evaluated in a chronic 8-week mouse model of house dust mite (HDM)-induced allergic airways inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28102066/erratum-in-vitro-evaluation-of-allergen-potencies-of-commercial-house-dust-mite-sublingual-immunotherapy-reagents
#6
Kyung Hee Park, Mina Son, Soo Young Choi, Hey Jung Park, Jae Hyun Lee, Kyoung Yong Jeong, Joo Shil Lee, Jung Won Park
This corrects the article on p. 124 in vol. 7, PMID: 25729619.
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102060/usefulness-of-house-dust-mite-nasal-provocation-test-in-asthma
#7
Inseon S Choi, Soo Jeong Kim, Joo Min Won, Myeong Soo Park
PURPOSE: We previously reported that the skin prick test was sensitive and the serum specific immunoglobulin E test was specific for predicting positive airway responses to house dust mites (HDMs) in patients with asthma. Because the nose and bronchus are one airway, the nasal provocation test would be more specific for predicting the bronchial responses to HDM than the skin test. METHODS: The allergy skin prick test and nasal and bronchial provocation tests using HDM (Dermatophagoides farinae) were performed in 41 young men (age, 19-28 years) who wanted military certification for asthma...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28098501/prevalence-of-house-dust-mite-allergens-in-low-income-homes-with-evaporative-coolers-in-a-semi-arid-climate
#8
James D Johnston, Taylor Barney, Justin Crandall, Marinn Brown, Tarah Westover, Sterling Paulson, Madeleine Smith, K Scott Weber
House dust mites are typically absent in homes in arid and semi-arid climates due to low humidity. Evaporative "swamp" cooling significantly increases indoor humidity in dry climates, and is suspected of promoting dust mite survival in these regions. We investigated the prevalence and concentration of mite allergens in dust from low-income homes (n = 22) with evaporative coolers in Utah County, Utah. Overall, 15 (68.2%) homes were positive for either Der p 1 or Der f 1 in at least one location. Geometric mean allergen levels in mattresses were 0...
January 18, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28093718/ribosomal-protein-s3-gene-silencing-protects-against-experimental-allergic-asthma
#9
Jinrui Dong, Wupeng Liao, Hong Yong Peh, Tze Khee Chan, W S Daniel Tan, Li Li, Amy Yong, W S Fred Wong
BACKGROUND AND PURPOSE: Ribosomal protein S3 (RPS3) is a 40S ribosomal protein of the S3P family essential for executing protein translation. RPS3 has recently been found to interact with the p65 subunit of the NF-κB complex, and promote p65 DNA-binding activity. Persistent activation of the NF-κB pathway is evident in allergic asthma. We hypothesized that gene silencing of lung RPS3 can ameliorate allergic airway inflammation. EXPERIMENTAL APPROACH: Gene silencing efficacy of RPS3 siRNA was screened in three different mouse cell lines by real-time PCR and immunoblotting...
January 17, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28078853/oxidative-stress-in-asthma-a-distinct-clinical-and-pathologic-feature
#10
Y Li, G P Li
Asthma is a type of chronic airway inflammation. Corticosteroids are inadequate for asthma therapy. However, it remains unclear whether oxidative stress is a distinct clinical and pathologic feature in asthma. We reviewed the articles on asthma-associated oxidative stress. The exposures to airborne allergens, such as house dust mite (HDM) and birch pollen, may not only trigger innate and adaptive immune responses but also cause oxidative stress damage in the airways. Allergen-induced reactive oxygen species (ROS) is involved in p38 MAPK, phosphoinositide-3-kinase (PI3K)/Akt and nuclear factor erythroid 2-related factor (Nrf2) kinase pathway signaling...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28076322/aeroallergen-der-p-2-promotes-motility-of-human-non-small-cell-lung-cancer-cells-via-toll-like-receptor-mediated-up-regulation-of-urokinase-type-plasminogen-activator-and-integrin-focal-adhesion-kinase-signaling
#11
Chun-Hsiang Lin, Hui-Han Lin, Cheng-Yi Kuo, Shao-Hsuan Kao
House dust mite (HDM) allergens are one of the major causes leading to respiratory hypersensitiveness and airway remodeling. Here we hypothesized that a major HDM allergen Der p 2 could increase cell motility and invasiveness of non-small cell lung cancer (NSCLC) cells. Our results showed that low dose (1 and 3 μg/mL) recombinant Der p 2 protein (DP2) enhanced the migration and invasiveness of human NSCLC cell A549, H1299 and CL1-5, but nonsignificantly altered their growth. Further investigation revealed that integrin αV level was increased and its downstream signaling including focal adhesion kinase (FAK) and paxillin were activated in A549 cells exposed to DP2...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28065336/sublingual-immunotherapy-dosing-regimens-what-is-ideal
#12
Jay J Jin, James T Li, Ludger Klimek, Oliver Pfaar
Sublingual immunotherapy (SLIT) is a treatment for allergic respiratory diseases that has demonstrated efficacy and safety. Several formulations of SLIT are now available worldwide for treatment of allergic rhinitis (AR). Grass tablets containing 15 to 25 μg of group 5 major allergen reduced combined AR symptoms and medication use by 23% to 41% in 3 treatment years and 2 follow-up years. Ragweed pollen tablets (12 μg of Ambrosia artemisiifolia 1) and liquid extracts (50 μg of Ambrosia artemisiifolia 1) reduced combined AR symptoms and medication use by 26% and 43%, respectively...
January 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28063044/characterization-of-group-2-innate-lymphoid-cells-in-allergic-airway-inflammation-models-in-the-mouse
#13
Bobby W S Li, Dior M J M Beerens, Maarten D Brem, Rudi W Hendriks
Allergic asthma is a chronic inflammatory lung disease mediated by type 2 cytokines produced by T helper 2 (Th2) cells as well as the recently discovered group 2 innate lymphoid cells (ILC2). Due to a lack of unique markers, the accurate phenotypic characterization and quantification of ILC2 requires a comprehensive panel of fluorescently labeled antibodies. The markers that are currently used to characterize ILC2 have not been standardized and often vary between research groups, which poses significant challenges when comparing data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28063043/subcutaneous-and-sublingual-immunotherapy-in-a-mouse-model-of-allergic-asthma
#14
Laura Hesse, Martijn C Nawijn
Allergic asthma, caused by inhaled allergens such as house dust mite or grass pollen, is characterized by reversible airway obstruction, associated with an eosinophilic inflammation of the airways, as well as airway hyper responsiveness and remodeling. The inhaled allergens trigger a type-2 inflammatory response with involvement of innate lymphoid cells (ILC2) and Th2 cells, resulting in high production of immunoglobulin E (IgE) antibodies. Consequently, renewed allergen exposure results in a classic allergic response with a distinct early and late phase, both resulting in bronchoconstriction and shortness of breath...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28063042/murine-models-of-allergic-asthma
#15
Eline Haspeslagh, Nincy Debeuf, Hamida Hammad, Bart N Lambrecht
Allergic asthma is a heterogeneous inflammatory lung disease affecting millions of people worldwide and with a steadily increasing incidence. Mouse models have been of utmost importance in uncovering key inflammatory cell types, cytokines, and pathways in the development and maintenance of allergic asthma. Historically, the mainstay in experimental asthma research was sensitizing rodents to the model protein antigen ovalbumin (OVA) with the pro-Th2 adjuvant aluminum hydroxide, followed by repetitive OVA exposures to the airways to initiate a Th2-skewed adaptive immune response leading to eosinophilic airway inflammation and airway hyperreactivity (AHR)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28062483/the-sialic-acid-to-urea-ratio-as-a-measure-of-airway-surface-hydration
#16
Charles R Esther, David B Hill, Brian Button, Shuai Shi, Corey M Jania, Elizabeth A Duncan, Claire M Doerschuk, Gang Chen, Sarath Ranganathan, Stephen Michael Stick, Richard C Boucher
INTRODUCTION: Although airway mucus dehydration is key to pathophysiology of cystic fibrosis (CF) and other airways diseases, measuring mucus hydration is challenging. We explored a robust method to estimate mucus hydration using sialic acid as a marker for mucin content. METHODS: Terminal sialic acid residues from mucins were cleaved by acid hydrolysis from airway samples, and concentrations of sialic acid, urea, and other biomarkers analyzed using mass spectrometry...
January 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28049194/early-intervention-improves-clinical-responses-to-house-dust-mite-immunotherapy-in-allergic-rhinitis-patients
#17
Shanshan Qi, Hao Chen, Nan Huang, Wenjing Li, Guanghui Liu, Yin Wang, Lintao Hu, Xiaolong Wang, Wei Zhang, Rongfei Zhu
BACKGROUND: Allergen immunotherapy (AIT) is the unique causal treatment for respiratory allergy. As AIT is expensive and of long duration, the availability of a marker predicting AIT responders is of crucial relevance. OBJECTIVE: To investigate clinical parameters correlated with effective AIT in allergic rhinitis (AR) patients. METHODS: This is a prospective, nonrandomized open study in which a total of 284 AR patients who had received house dust mite (HDM) subcutaneous AIT were enrolled from January 2011 to December 2015, and then followed up for 3 consecutive years...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28045938/exposure-to-indoor-allergens-in-different-residential-settings-and-its-influence-on-ige-sensitization-in-a-geographically-confined-austrian-cohort
#18
Teresa Stemeseder, Bettina Schweidler, Patrick Doppler, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Martin Himly, Roland Lang, Joerg Zumbach, Gertie J Oostingh, Thomas Hawranek, Arne C Bathke, Gabriele Gadermaier
BACKGROUND: Exposure to indoor allergens is crucial for IgE sensitization and development of allergic symptoms. Residential settings influence the allergen amount in house dust and hence allergic sensitization. Within this study, we investigated allergen exposure and molecule-based IgE levels in a geographically confined region and evaluated the impact of housing, pets and cleaning. METHODS: 501 adolescents from Salzburg, Austria participated in this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28042341/anti-angiogenic-nanotherapy-inhibits-airway-remodeling-and-hyper-responsiveness-of-dust-mite-triggered-asthma-in-the-brown-norway-rat
#19
Gregory M Lanza, John Jenkins, Anne H Schmieder, Aigul Moldobaeva, Grace Cui, Huiying Zhang, Xiaoxia Yang, Qiong Zhong, Jochen Keupp, Ismail Sergin, Krishna S Paranandi, Lindsey Eldridge, John S Allen, Todd Williams, Michael J Scott, Babak Razani, Elizabeth M Wagner
Although angiogenesis is a hallmark feature of asthmatic inflammatory responses, therapeutic anti-angiogenesis interventions have received little attention. Objective: Assess the effectiveness of anti-angiogenic Sn2 lipase-labile prodrugs delivered via αvβ3-micellar nanotherapy to suppress microvascular expansion, bronchial remodeling, and airway hyper-responsiveness in Brown Norway rats exposed to serial house dust mite (HDM) inhalation challenges. Results: Anti-neovascular effectiveness of αvβ3-mixed micelles incorporating docetaxel-prodrug (Dxtl-PD) or fumagillin-prodrug (Fum-PD) were shown to robustly suppress neovascular expansion (p<0...
2017: Theranostics
https://www.readbyqxmd.com/read/28042004/the-potential-role-of-allergen-immunotherapy-in-stepping-down-asthma-treatment
#20
Pascal Demoly, Melina Makatsori, Thomas B Casale, Moises A Calderon
For patients whose asthma is controlled and who have a low risk for future exacerbations, current guidelines recommend gradually stepping down pharmacotherapy to identify the lowest dose needed to maintain control. This review article will discuss the benefits and risks of step down in asthma management and the different strategies of achieving step down with particular focus on allergen immunotherapy (AIT). A literature search was conducted to identify studies that assessed the effect of AIT on asthma step down and evaluated this and asthma control as one of the outcomes...
December 29, 2016: Journal of Allergy and Clinical Immunology in Practice
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