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https://www.readbyqxmd.com/read/29450658/modified-allergens-for-immunotherapy
#1
REVIEW
Pattraporn Satitsuksanoa, Anna Głobińska, Kirstin Jansen, Willem van de Veen, Mübeccel Akdis
PURPOSE OF REVIEW: During the past few decades, modified allergens have been developed for use in allergen-specific immunotherapy (AIT) with the aim to improve efficacy and reduce adverse effects. This review aims to provide an overview of the different types of modified allergens, their mechanism of action and their potential for improving AIT. RECENT FINDINGS: In-depth research in the field of allergen modifications as well as the advance of recombinant DNA technology have paved the way for improved diagnosis and research on human allergic diseases...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29449864/seasonal-variation-in-circulating-group-2-innate-lymphoid-cells-in-mugwort-allergic-asthmatics-during-and-outside-pollen-season
#2
Qing Miao, Yan Wang, Yong-Ge Liu, Yi-Xin Ren, Hui Guan, Zhen Li, Wei Xu, Li Xiang
Background: Group 2 innate lymphoid cells (ILC2s) are a newly identified cell population with the potent capability to produce Th2-type cytokines in a non-antigen specific manner. Previous study demonstrated that enhanced circulating ILC2s in cat-allergic patient after experimental allergen challenge, whereas the effects of natural allergen exposure on peripheral ILC2s are still unclear. We therefore examined the variations in circulating ILC2s among asthmatic patients sensitized to different allergens in- and outside- pollen season...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29444897/role-of-nkp46-natural-killer-cells-in-house-dust-mite-driven-asthma
#3
Eline Haspeslagh, Mary J van Helden, Kim Deswarte, Sofie De Prijck, Justine van Moorleghem, Louis Boon, Hamida Hammad, Eric Vivier, Bart N Lambrecht
House dust mite (HDM)-allergic asthma is driven by T helper 2 (Th2) lymphocytes, but also innate immune cells control key aspects of the disease. The precise function of innate natural killer (NK) cells during the initiation and propagation of asthma has been very confusing, in part because different, not entirely specific, strategies were used to target these cells. We show that HDM inhalation rapidly led to the accumulation of NK cells in the lung-draining lymph nodes and of activated CD69 + NK cells in the bronchoalveolar lumen...
February 14, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29434645/atopy-and-related-clinical-symptoms-among-swiss-medical-students-from-2007-to-2015
#4
Lukas Steinegger, Stephan Regenass, Lucas M Bachmann, Elsbeth Probst, Urs C Steiner
Background: Atopic allergy is a widespread disease with increasing prevalence in the second half of the twentieth century and is most often associated with clinical symptoms, like rhinoconjunctivitis, asthma or eczema. This study explored the prevalence of atopy and polysensitization in nine cohorts of Swiss medical students during the period of 2007-2015. Furthermore, the self-reported allergic symptoms, such as rhinoconjunctivitis, asthma and eczema, among students with and without atopy were assessed...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29432959/impact-of-adverse-event-solicitation-on-the-safety-profile-of-sq-house-dust-mite-sublingual-immunotherapy-tablet
#5
Hendrik Nolte, David I Bernstein, Gordon L Sussman, Bodil Svanholm Fogh, Susan Lu, Bernt Husøy, Harold S Nelson
BACKGROUND: It has been recommended that sublingual immunotherapy (SLIT) safety be assessed using solicited adverse event (AE) collection methods. OBJECTIVES: To describe the impact on the safety profile of SQ house dust mite (HDM) SLIT-tablet (12 SQ-HDM dose) when pre-specified local application site reactions were solicited vs unsolicited, and discuss ramifications of AE solicitation. METHODS: Subjects were randomized to daily 12 SQ-HDM or placebo for up to 52 weeks in 4 double-blinded, multicenter trials...
February 9, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29427643/new-mechanism-underlying-il-31-induced-atopic-dermatitis
#6
Jianghui Meng, Masaki Moriyama, Micha Feld, Joerg Buddenkotte, Timo Buhl, Attila Szöllösi, Jingming Zhang, Paul Miller, Andre Ghetti, Michael Fischer, Peter W Reeh, Chunxu Shan, Jiafu Wang, Martin Steinhoff
BACKGROUND: T helper type 2 cell-released interleukin 31 (IL-31) is a critical mediator in atopic dermatitis (AD), a prevalent and debilitating chronic skin disorder. Brain-derived natriuretic peptide (BNP) has been described as a central itch mediator. The importance of BNP in peripheral (skin-derived) itch and its functional link to IL-31 within the neuro-immune axis of the skin is unknown. OBJECTIVE: To investigate the function of BNP in the peripheral sensory system and skin in IL-31-induced itch and neuro-epidermal communication in AD...
February 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29426044/dysbiosis-of-inferior-turbinate-microbiota-is-associated-with-high-total-ige-levels-in-allergic-rhinitis-patients
#7
Dong-Wook Hyun, Hyun Jin Min, Min-Soo Kim, Tae Woong Whon, Na-Ri Shin, Pil Soo Kim, Hyun Sik Kim, June Young Lee, Woorim Kang, Augustine M K Choi, Joo-Heon Yoon, Jin-Woo Bae
Abnormalities in the human microbiota are associated with the etiology of allergic diseases. Although disease site-specific microbiota may be associated with disease pathophysiology, the role of the nasal microbiota is unclear. We sought to characterize the microbiota of the site of allergic rhinitis, inferior turbinate, in subjects with allergic rhinitis (n=20) and healthy controls (n=12), and to examine the relationship of mucosal microbiota with disease occurrence, sensitized allergen number, allergen-specific- and total-IgE levels...
February 5, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29423377/accuracy-of-serum-specific-ige-test-with-microfluidic-array-enzyme-linked-immunosorbent-assay-for-diagnosing-inhalant-allergen-sensitization-in-asthma-and-or-rhinitis-allergy-patients-in-jakarta-indonesia
#8
Julfreser Sinurat, Iris Rengganis, Cleopas Martin Rumende, Kuntjoro Harimurti
Background: Asthma and allergic rhinitis are a global health burden. Inhalant allergens worsen the symptoms and clinical manifestations of asthma and allergic rhinitis. Skin prick test is the gold standard for diagnosing allergen sensitization but is associated with some limitations. In contrast, in vitro serum-specific immunoglobulin E (SSIgE) test is convenient and is not associated with an anaphylactic risk. Objective: The present study compared the accuracy of the SSIgE test by using microfluidic array enzyme-linked immunosorbent assay (ELISA) with that of the skin prick test for diagnosing inhalant allergen sensitization in patients with asthma and/or allergic rhinitis...
January 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29423373/changes-in-basophil-activation-during-immunotherapy-with-house-dust-mite-and-mugwort-in-patients-with-allergic-rhinitis
#9
Sae-Hoon Kim, Soon-Hee Kim, Soo-Jie Chung, Jung-Hyun Kim, Suh-Young Lee, Byung-Keun Kim, Kyung-Whan Lim, Yoon-Seok Chang
Background: The basophil activation test (BAT) is a promising tool for monitoring allergen-specific immunotherapy responses. Objective: We aimed to investigate the changes in basophil activation in response to the inhalant allergens of house dust mite (HDM) and mugwort pollen during immunotherapy in patients with allergic rhinitis. Methods: We enrolled patients with allergic rhinitis who were to receive subcutaneous immunotherapy for the inhalant allergens HDM or mugwort...
January 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29422615/house-dust-mite-and-cockroach-specific-immunoglobulin-e-sensitization-is-associated-with-diabetes-mellitus-in-the-adult-korean-population
#10
Mee Kyoung Kim, Jee Sun Jeong, Kyungdo Han, Ki Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Immunoglobulin E (IgE) is known to activate mast cells. Prior studies have shown that mast cells contribute to diet-induced obesity and diabetes mellitus (DM). We aimed to determine whether adults with IgE sensitization were at risk of DM. We performed assays regarding serum total IgE and allergen-specific IgE levels against the house dust mite, the cockroach, and the dog on 1,528 adults randomly sampled from every age and gender group in various districts. The total and three allergen-specific IgE levels were positively correlated with fasting glucose level and insulin resistance...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420850/chitotriosidase-inhibits-allergic-asthmatic-airways-via-regulation-of-tgf-%C3%AE-expression-and-foxp3-treg-cells
#11
Jung Yeon Hong, Mina Kim, In Suk Sol, Kyung Won Kim, Chang-Min Lee, Jack A Elias, Myung Hyun Sohn, Chun Geun Lee
BACKGROUND: Chitotriosidase (Chitnase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. We hypothesized that Chit1 plays a significant role in the pathogenesis of allergic asthma. To identify the role of Chit1, the mechanisms that underlie these contributions and the relevance of these murine findings to childhood asthma. METHODS: Wild type and Chit1-deficient mice and cells in culture were used to define the roles of Chit1 in models of allergic adaptive Th2 inflammation...
February 8, 2018: Allergy
https://www.readbyqxmd.com/read/29408409/characterization-of-a-hybrid-protein-designed-with-segments-of-allergens-from-blomia-tropicalis-and-dermatophagoides-pteronyssinus
#12
Dalgys Martínez, Jose Fernando Cantillo, Helber Herazo, Judith Wortmann, Walter Keller, Luis Caraballo, Leonardo Puerta L
BACKGROUND: Sensitization to allergens of the house dust mites Dermatophagoides pteronyssinnus and Blomia tropicalis is an important risk factor for asthma and allergic diseases. Allergen-specific immunotherapy is currently based on natural allergen extracts, however, in the last years recombinant allergens with different modifications have shown promising immunological properties that may be advantageously applied for developing novel allergy vaccines. METHODS: A hybrid molecule (MAVAC-BD-2) containing epitopes of B...
February 3, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29398016/effect-of-mite-allergenic-components-on-innate-immune-response-synergy-of-protease-group-1-3-and-non-protease-group-2-7-allergens
#13
Sui-Chu Yin, En-Chih Liao, Chi-Xin Ye, Ching-Yun Chang, Jaw-Ji Tsai
The major mite allergenic components of protease allergens (group 1,3) and non-protease allergens (group 2,7) derived from Dermatophagoides peronyssinus (Dp) and D. farinae (Df) are reported to be capable of sensitizing 80-90% of mite-allergic patients. Although protease and non-protease allergens have been demonstrated to trigger innate and adaptive immune responses through epithelium activation, the simultaneous or sequential effects of both groups of allergens has not been reported. Since all allergens are present in the mite crude extracts, it is important to determine whether these allergens can synergistically trigger the immune responses to cause airway inflammation...
October 26, 2017: Immunobiology
https://www.readbyqxmd.com/read/29393977/itgb4-is-essential-for-containing-hdm-induced-airway-inflammation-and-airway-hyperresponsiveness
#14
Chi Liu, Lin Yuan, Yizhou Zou, Ming Yang, Yu Chen, Xiangping Qu, Huijun Liu, Jianxin Jiang, Yang Xiang, Xiaoqun Qin
Airway epithelial cells play a significant role in the pathogenesis of asthma. Although the structural and functional defects of airway epithelial cells have been postulated to increase asthma susceptibility and exacerbate asthma severity, the mechanism and implication of these defects remain uncertain. Integrin β4 (ITGB4) is a structural adhesion molecule that is downregulated in the airway epithelium of asthma patients. In this study, we demonstrated that ITGB4 deficiency leads to severe allergy-induced airway inflammation and airway hyper-responsiveness (AHR) in mice...
February 2, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29384667/effects-of-simulated-smog-atmospheres-in-rodent-models-of-metabolic-and-immunologic-dysfunction
#15
Marie McGee Hargrove, Samantha J Snow, Robert W Luebke, Charles E Wood, Jonathan Krug, Q Todd Krantz, Charly King, Carey Copeland, Shaun D McCullough, Kymberly M Gowdy, Urmila Kodavanti, M Ian Gilmour, Stephen Gavett
Air pollution is a diverse and dynamic mixture of gaseous and particulate matter, limiting our understanding of associated adverse health outcomes. The biological effects of two simulated smog atmospheres (SA) with different compositions but similar air quality health indexes were compared in a non-obese diabetic rat model (Goto-Kakizaki, GK) and three mouse immune models (house dust mite (HDM) allergy, antibody response to heat-killed pneumococcus, and resistance to influenza A infection). In GK rats, both SA-PM (high particulate matter) and SA-O3 (high ozone) decreased cholesterol levels immediately after a 4-hour exposure, whereas only SA-O3 increased airflow limitation...
January 31, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29377900/rewired-rnai-mediated-genome-surveillance-in-house-dust-mites
#16
Mosharrof Mondal, Pavel Klimov, Alex Sutton Flynt
House dust mites are common pests with an unusual evolutionary history, being descendants of a parasitic ancestor. Transition to parasitism is frequently accompanied by genome rearrangements, possibly to accommodate the genetic change needed to access new ecology. Transposable element (TE) activity is a source of genomic instability that can trigger large-scale genomic alterations. Eukaryotes have multiple transposon control mechanisms, one of which is RNA interference (RNAi). Investigation of the dust mite genome failed to identify a major RNAi pathway: the Piwi-associated RNA (piRNA) pathway, which has been replaced by a novel small-interfering RNAs (siRNAs)-like pathway...
January 29, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29374499/long-term-efficacy-of-standardised-specific-subcutaneous-immunotherapy-in-children-with-persistent-allergic-rhinitis-due-to-multiple-allergens-including-house-dust-mites
#17
Y Song, J Long, T Wang, J Xie, M Wang, G Tan
OBJECTIVES: To observe the five-year efficacy of standardised specific subcutaneous immunotherapy for house dust mite allergy in monosensitised and polysensitised children with persistent allergic rhinitis. METHODS: From January 2007 to August 2009, 236 children with persistent allergic rhinitis were divided into 2 groups: 1 group received standardised specific subcutaneous immunotherapy using house dust mite extract; the other received pharmacotherapy with intranasal corticosteroids and oral antihistamines...
January 28, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29367592/persistent-activation-of-interlinked-type-2-airway-epithelial-gene-networks-in-sputum-derived-cells-from-aeroallergen-sensitized-symptomatic-asthmatics
#18
Anya C Jones, Niamh M Troy, Elisha White, Elysia M Hollams, Alexander M Gout, Kak-Ming Ling, Anthony Kicic, Stephen M Stick, Peter D Sly, Patrick G Holt, Graham L Hall, Anthony Bosco
Atopic asthma is a persistent disease characterized by intermittent wheeze and progressive loss of lung function. The disease is thought to be driven primarily by chronic aeroallergen-induced type 2-associated inflammation. However, the vast majority of atopics do not develop asthma despite ongoing aeroallergen exposure, suggesting additional mechanisms operate in conjunction with type 2 immunity to drive asthma pathogenesis. We employed RNA-Seq profiling of sputum-derived cells to identify gene networks operative at baseline in house dust mite-sensitized (HDMS) subjects with/without wheezing history that are characteristic of the ongoing asthmatic state...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29367458/a-pathophysiological-role-of-pde3-in-allergic-airway-inflammation
#19
Jan Beute, Melanie Lukkes, Ewout P Koekoek, Hedwika Nastiti, Keerthana Ganesh, Marjolein Jw de Bruijn, Steve Hockman, Menno van Nimwegen, Gert-Jan Braunstahl, Louis Boon, Bart N Lambrecht, Vince C Manganiello, Rudi W Hendriks, Alex KleinJan
Phosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in various cell types involved in allergic airway inflammation. Although PDE4 inhibition attenuates allergic airway inflammation, reported side effects preclude its application as an antiasthma drug in humans. Case reports showed that enoximone, which is a smooth muscle relaxant that inhibits PDE3, is beneficial and lifesaving in status asthmaticus and is well tolerated. However, clinical observations also showed antiinflammatory effects of PDE3 inhibition...
January 25, 2018: JCI Insight
https://www.readbyqxmd.com/read/29363670/noxa-hsp27-complex-delays-degradation-of-ubiquitylated-ikb%C3%AE-in-airway-epithelial-cells-to-reduce-pulmonary-inflammation
#20
C Zhang, J T Jones, H S Chand, M G Wathelet, C M Evans, B Dickey, J Xiang, Y A Mebratu, Y Tesfaigzi
IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared with noxa+/+ mice. Noxa expression blocked transforming necrosis factor alpha (TNF-α)-induced nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and the production of pro-inflammatory cytokines...
January 24, 2018: Mucosal Immunology
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