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https://www.readbyqxmd.com/read/29036225/human-plasma-derived-c1-esterase-inhibitor-concentrate-has-limited-effect-on-house-dust-mite-induced-allergic-lung-inflammation-in-mice
#1
Ingrid Stroo, Jack Yang, Adam A Anas, J Daan de Boer, Gerard van Mierlo, Dorina Roem, Diana Wouters, Ruchira Engel, Joris J T H Roelofs, Cornelis van 't Veer, Tom van der Poll, Sacha Zeerleder
C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a)...
2017: PloS One
https://www.readbyqxmd.com/read/29035391/a-gammaherpesvirus-provides-protection-against-allergic-asthma-by-inducing-the-replacement-of-resident-alveolar-macrophages-with-regulatory-monocytes
#2
Bénédicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil, Catherine Sabatel, Daniel Desmecht, François Lallemand, Philippe Martinive, Hamida Hammad, Martin Guilliams, Benjamin Dewals, Alain Vanderplasschen, Bart N Lambrecht, Fabrice Bureau, Laurent Gillet
The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4) inhibited the development of house dust mite (HDM)-induced experimental asthma by modulating lung innate immune cells. Specifically, infection with MuHV-4 caused the replacement of resident alveolar macrophages (AMs) by monocytes with regulatory functions...
October 16, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29032417/clinical-evaluation-for-sublingual-immunotherapy-with-dermatophagoides-farinae-drops-in-adult-patients-with-allergic-asthma
#3
C Zhong, W Yang, Y Li, L Zou, Z Deng, M Liu, X Huang
PURPOSE: The efficacy and safety of sublingual immunotherapy (SLIT) in house dust mite-induced allergic asthma (AA) have yet to be firmly established, especially in adult patients. Our objective is to evaluate the efficacy of SLIT with Dermatophagoides farinae drops in adult patients with AA. METHODS: One hundred and thirty-four adult patient data with house dust mite (HDM)-induced AA who had been treated for 2 years were collected. These patient data that we collected were divided into the SLIT group (n = 85) and control group (n = 49)...
October 14, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29028288/hypochlorous-acid-is-anti-pruritic-and-anti-inflammatory-in-a-mouse-model-of-atopic-dermatitis
#4
Tomoki Fukuyama, Britta C Martel, Keith Linder, Sarah Ehling, Joy Rachel Ganchingco, Wolfgang Bäumer
BACKGROUND: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis, however the specific anti-pruritic mechanism of action remains unclear. OBJECTIVE: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode of action. METHODS: In this study, the effects of topical administration of HOCl hydrogel (0...
October 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29026003/neutralization-of-either-il-17a-or-il-17f-is-sufficient-to-inhibit-house-dust-mite-induced-allergic-asthma-in-mice
#5
Pauline Chenuet, Louis Fauconnier, Fahima Madouri, Tiffany Marchiol, Nathalie Rouxel, Aurélie Ledru, Pascal Mauny, Rachel Lory, Catherine Uttenhove, Jacques van Snick, Yoichiro Iwakura, Franco di Padova, Valérie Quesniaux, Dieudonnée Togbe, Bernhard Ryffel
T helper (Th)17 immune response participates in allergic lung inflammation and asthma is reduced in the absence of interleukin (IL)-17 in mice. Since IL-17A and IL-17F are induced and bind the shared receptor IL-17RA, we asked whether both IL-17A and IL-17F contribute to house dust mite (HDM) induced asthma. We report that allergic lung inflammation is attenuated in absence of either IL-17A or IL-17F with reduced airway hyperreactivity, eosinophilic inflammation, goblet cell hyperplasia, cytokine and chemokine production as found in absence of IL-17RA...
October 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29022537/respiratory-comorbidity-in-south-african-children-with-atopic-dermatitis
#6
C L Gray, M E Levin, G Du Toit
BACKGROUND: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. OBJECTIVES: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD. METHODS: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28992042/prominent-ige-binding-and-cytokine-inducing-capacities-of-a-newly-cloned-n-terminal-region-of-der-f-14-an-apolipophorin-like-house-dust-mite-allergen
#7
Kareem Gamal ElRamlawy, Takashi Fujimura, Tsunehiro Aki, Akiyasu Okada, Takayuki Suzuki, Takuya Abe, Takaharu Hayashi, Michael J Epton, Wayne R Thomas, Inas Hussein Rafeet, Diaa Beshr Al-Azhary, Kazuhisa Ono, Seiji Kawamoto
We previously characterized a 177 kDa allergen, M-177, from Dermatophagoides farinae. Thereafter, a counterpart to M-177 for Euroglyphus maynei was cloned as Eur m 14, and its sequence revealed that two environmental allergens, Mag 1 and Mag 3, are digested fragments of M-177. The aims of this study were to clone the cDNA of Der f 14 corresponding to M-177 and to elucidate the allergenic capacities of the N-terminal fragment of Der f 14 (Der f 14-N). Recombinant allergens were produced as trigger-factor-fused proteins in Escherichia coli...
September 11, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28983982/investigation-of-the-correlation-of-serum-il-31-with-severity-of-dermatitis-in-an-experimental-model-of-canine-atopic-dermatitis-using-beagle-dogs
#8
Rosanna Marsella, Kim Ahrens, Rachel Sanford
BACKGROUND: IL-31 is a cytokine that is believed to play an important role in atopic dermatitis (AD). IL-31 levels positively correlate with disease severity in children with AD. Currently, there is no study that has investigated such a correlation in atopic dogs. HYPOTHESIS/OBJECTIVE: The purpose of this study was to evaluate the correlation between IL-31 serum levels and severity of dermatitis. It was hypothesized that a positive correlation exists between severity of AD and circulating levels of IL-31...
October 6, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28982170/a-combined-transcriptome-and-proteome-analysis-extends-the-allergome-of-house-dust-mite-dermatophagoides-species
#9
Véronique Bordas-Le Floch, Maxime Le Mignon, Laetitia Bussières, Karine Jain, Armelle Martelet, Véronique Baron-Bodo, Emmanuel Nony, Laurent Mascarell, Philippe Moingeon
BACKGROUND: House dust mites (HDMs) such as Dermatophagoides farinae and D. pteronyssinus represent major causes of perennial allergy. HDM proteomes are currently poorly characterized, with information mostly restricted to allergens. As of today, 33 distinct allergen groups have been identified for these 2 mite species, with groups 1 and 2 established as major allergens. Given the multiplicity of IgE-reactive mite proteins, potential additional allergens have likely been overlooked. OBJECTIVE: To perform a comprehensive characterization of the transcriptomes, proteomes and allergomes of D...
2017: PloS One
https://www.readbyqxmd.com/read/28981975/lung-function-improvement-and-airways-inflammation-reduction-in-asthmatic-children-after-a-rehabilitation-program-at-moderate-altitude
#10
Eugen Bersuch, Florian Gräf, Ellen D Renner, Andreas Jung, Claudia Traidl-Hoffmann, Roger Lauener, Caroline Roduit
BACKGROUND: Rehabilitational programs at moderate altitude (1500m to 2500m) showed improvement of lung function and reduction of airways inflammation in asthmatic adults. Allergen avoidance was postulated as the major cause of these improvements. METHODS: Spirometries of 344 and fractional exhaled nitric oxide measurements (FeNO) of 124 asthmatic children and adolescents, staying in a rehabilitation hospital in Davos (1590m) with at least 14 days between admission and discharge, were analysed in associations with atopic sensitisation (skin-prick testing and/or specific IgE), level of asthma control, and inhalative corticosteroid (ICS) dose...
October 5, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28979688/the-role-of-il-25-in-the-reduction-of-oxidative-stress-and-the-apoptosis-of-airway-epithelial-cells-with-specific-immunotherapy-in-an-asthma-mouse-model
#11
Xiefang Yuan, Eryi Wang, Xiaojun Xiao, Junyi Wang, Xiaomeng Yang, Pingchang Yang, Guoping Li, Zhigang Liu
Oxidative stress and cell apoptosis play important roles in the pathogenesis of asthma. Specific immunotherapy (SIT) is the only curative approach for asthma and is effective at decreasing asthmatic oxidation and cell apoptosis, but the mechanisms remain unclear. In this study, by using in vivo and in vitro models, we indirectly demonstrated that SIT alleviated the apoptosis and oxidative stress of bronchial epithelial cells in an asthma model through regulating interleukin (IL)-25. Female BALB/c mice were used for an asthma model induced by exposure to house dust mite (HDM) extracts as allergens...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28978515/late-gestation-maternal-dietary-methyl-donor-and-cofactor-supplementation-in-sheep-partially-reverses-protection-against-allergic-sensitization-by-iugr
#12
Amy L Wooldridge, Robert J Bischof, Hong Liu, Gary K Heinemann, Damien S Hunter, Lynne C Giles, Rebecca A Simmons, Yu-Chin Lien, Wenyun Lu, Joshua D Rabinowitz, Karen L Kind, Julie A Owens, Vicki L Clifton, Kathryn L Gatford
Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our previous work suggest restricted growth in utero (IUGR) is protective against allergic disease. The mechanisms are not clearly defined but reduced fetal abundance and altered metabolism of methyl donors are hypothesized as possible underlying mechanisms. We therefore examined whether late gestation maternal dietary methyl donor and co-factor supplementation of the placentally-restricted (PR) sheep pregnancy would reverse allergic protection in progeny...
October 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28977706/dust-mite-induces-multiple-polar-t-cell-axes-in-human-skin
#13
Kunal Malik, Benjamin Ungar, Sandra Garcet, Riana Dutt, Daniel Dickstein, Xiuzhong Zheng, Hui Xu, Yeriel D Estrada, Mayte Suárez-Fariñas, Avner Shemer, James G Krueger, Emma Guttman-Yassky
BACKGROUND: House dust mite/HDM atopy patch test/APT elicits positive reactions in a high fraction of atopic dermatitis/AD and healthy individuals. Experimental systems for new-onset/chronic AD are needed to support rapid therapeutic development, particularly since animal models representing human AD are lacking. While HDM APT has been considered to simulate AD, its suitability to model AD's emerging Th2/Th22 phenotype with Th1 and Th17 components is unknown. OBJECTIVE: To assess whether HDM APT reproduces AD...
October 4, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28972433/thymic-stromal-lymphopoietin-contribution-to-the-recruitment-of-circulating-fibrocytes-to-the-lung-in-a-mouse-model-of-chronic-allergic-asthma
#14
Zhuang-Gui Chen, Ping Meng, Hong-Tao Li, Ming Li, Li-Fen Yang, Yan Yan, Ya-Ting Li, Xiao-Ling Zou, De-Yun Wang, Tian-Tuo Zhang
OBJECTIVE: Fibrocyte localization to the airways and thymic stromal lymphopoietin (TSLP) overexpression in the lung are features of severe asthma. The aim of this study was to determine whether TSLP contributes to fibrocyte trafficking and airway remodelling in a mouse model of allergic asthma. METHODS: We established a chronic asthma animal model by administering house dust mite (HDM) extracts intranasally for up to 5 consecutive weeks. Mouse anti-TSLP monoclonal antibody (mAb) was given intraperitoneally starting the 4(th) week...
October 3, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28966674/tlr4-antagonist-suppresses-airway-remodeling-in-asthma-by-inhibiting-the-t-helper-2-response
#15
Ming Li, Zhao-Ni Wang, Li-Fen Yang, Yan Yan, Liang-Ming Cai, Ya-Ting Li, Yong-Kang Qiao, Zhuang-Gui Chen
Airway remodeling is a hallmark of bronchial asthma. Our group has previously reported that the thymic stromal lymphopoietin (TSLP), an airway epithelial-derived cytokine, has a central role in the pathogenesis of airway remodeling, and that toll-like receptor (TLR) 4 signaling in epithelial cells may trigger T-helper 2 (Th2) immune responses by overexpression of TSLP. However, it is currently unclear whether TLR4 is a target in the treatment of airway remodeling in asthma. The present study established a house dust mite (HDM)-induced chronic asthmatic model in female BALB/c mice and treated the HDM-exposed mice with 3 mg/kg TAK242, as a TLR4 antagonist, 30 min prior to HDM challenge for up to 2 weeks...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962623/quality-of-life-improvement-after-a-three-year-course-of-sublingual-immunotherapy-in-patients-with-house-dust-mite-and-grass-pollen-induced-allergic-rhinitis-results-from-real-life
#16
Silviya Mihaylova Novakova, Maria Toncheva Staevska, Plamena Ivanova Novakova, Manuela Dimitrova Yoncheva, Maria Stoykova Bratoycheva, Nina Mihaylova Musurlieva, Valeri Dimitrov Tzekov, Dimitar Georgiev Nicolov
BACKGROUND: Along with its high prevalence, the burden of allergic rhinitis rests upon the serious impact on quality of life of patients. Allergic rhinitis is associated with impairments in daily activities, work and school performance, and practical problems. Patients suffer from sleep disorders and emotional problems. Тhe advantages of sublingual immunotherapy on quality of life have only recently begun to emerge. The objective of this prospective real-life study was to evaluate the effect of a three-year course of sublingual immunotherapy with house dust mite (HDM) and grass pollen extracts on quality of life in adults with allergic rhinitis...
September 29, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28962133/comparison-of-the-roles-of-house-dust-mite-allergens-ovalbumin-and-lipopolysaccharides-in-the-sensitization-of-mice-to-establish-a-model-of-severe-neutrophilic-asthma
#17
Aijun Jia, Yueling Wang, Wenjin Sun, Bing Xiao, Lin Mu, Yan Wei, Li Xu, Cong Peng, Dongshan Zhang, Huahao Shen, Xudong Xiang
Neutrophilic asthma (NA) is associated with a severe disease course and poor response to corticosteroids. The present study aimed to compare the effects of various concentrations of house dust mite (HDM) allergens, ovalbumin (OVA), the major egg allergen, and lipopolysaccharide (LPS) in combination on the onset of severe NA. Female C57BL/6 mice were grouped according to a random number table and intranasally sensitized with HDM/LPS/OVA extracts on days 0, 1 and 2 of the study. In group 1, mice received 50 µg HDM + 50 µg OVA + 15 µg LPS, mice in group 2 received 50 µg HDM + 100 µg OVA + 15 µg LPS, mice in group 3 received 100 µg HDM + 50 µg OVA + 15 µg LPS and those in group 4 received 100 µg HDM + 100 µg OVA + 15 µg LPS, while mice in the control group received saline only...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28950285/could-sublingual-immunotherapy-affect-oral-health-in-children-with-asthma-and-or-allergic-rhinitis-sensitized-to-house-dust-mite
#18
Ayca Kiykim, Gonca Mumcu, Ismail Ogulur, Elif Karakoc-Aydiner, Haner Direskeneli, Safa Baris, Hasret Cagan, Ahmet Ozen
BACKGROUND: Sublingual immunotherapy (SLIT) has been successfully employed in IgE-mediated respiratory allergies. However, it is not known whether the modulation of immune responses in the sublingual area during SLIT has any deleterious effect on oral health. We sought to determine the oral health prospectively in children receiving SLIT for house dust mite allergy. MATERIAL AND METHODS: Eighteen children with allergic asthma and/or rhinitis and 31 age-matched healthy controls (HC) were included in an open-labeled trial...
September 27, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28950271/bioavailability-of-house-dust-mite-allergens-in-sublingual-allergy-tablets-is-highly-dependent-on-the-formulation
#19
Katsuyo Ohashi-Doi, Hirokazu Kito, Weibin Du, Hiroshi Nakazawa, Henrik Ipsen, Pernille Gudmann, Kaare Lund
BACKGROUND: In sublingual immunotherapy (SLIT), the immune system is addressed by solubilized allergen that interacts with immunocompetent cells of the oral mucosa, the efficiency of which is governed by 2 main factors of SLIT allergen bioavailability: the allergen concentration and the mucosal contact time. Recently, 3 house dust mite (HDM) SLIT tablets were developed that differ with regard to allergen content, nominal strength (maintenance doses: 6 SQ-HDM/10,000 Japanese Allergen Units [JAU], 12 SQ-HDM/ 20,000 JAU, and 300 IR/57,000 JAU), and formulation (freeze-dried/compressed)...
September 27, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28950268/the-sq-house-dust-mite-slit-tablet-is-well-tolerated-in-patients-with-house-dust-mite-respiratory-allergic-disease
#20
Waltraud Emminger, María Dolores Hernández, Victòria Cardona, Frank Smeenk, Bodil S Fogh, Moises A Calderon, Frederic de Blay, Vibeke Backer
BACKGROUND: The SQ house dust mite (HDM) SLIT-tablet (ALK, Denmark) addresses the underlying cause of HDM respiratory allergic disease, and a clinical effect has been demonstrated for both HDM allergic rhinitis and allergic asthma. Here, we present pooled safety data from an adult population with HDM respiratory allergy, with particular focus on the impact of asthma on the SQ HDM SLIT-tablet tolerability profile. METHODS: Safety data from 2 randomised double-blind, placebo-controlled clinical trials were included: MT-04: 834 adults with HDM allergic asthma not well controlled by inhaled corticosteroids and with HDM allergic rhinitis, and MT-06: 992 adults with moderate-to-severe HDM allergic rhinitis despite the use of allergy pharmacotherapy and with or without asthma...
September 27, 2017: International Archives of Allergy and Immunology
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