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Infant, ventilation

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https://www.readbyqxmd.com/read/29933338/temperature-and-humidity-associated-with-artificial-ventilation-in-the-premature-infant-an-integrative-review-of-the-literature
#1
Jane L Ralphe, Robin B Dail
BACKGROUND: Approximately half of the 55,000 very low birth-weight infants (<1500 g) born in the United States each year develop bronchopulmonary dysplasia (BPD). Many etiologies have been associated with the development of BPD, including aberrant temperature/humidity levels of artificial ventilation. PURPOSE: The purpose of this literature review is to explore what is known regarding inspired air temperature/humidity levels from artificial ventilation in very premature infants, focusing on what levels these infants actually receive, and what factors impact these levels...
June 21, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29933287/leak-compensation-during-volume-guarantee-with-the-dr%C3%A3-ger-babylog-vn500-neonatal-ventilator
#2
Eniko Szakmar, Colin J Morley, Gusztav Belteki
OBJECTIVES: To investigate how compensating for endotracheal tube leaks by targeting the leak-compensated tidal volume affects measured physiologic and ventilator variables during neonatal mechanical ventilation. DESIGN: Retrospective observational study. SETTING: A level III Neonatal ICU. PATIENTS: We enrolled 30 neonates who were ventilated using synchronized intermittent positive pressure mode with volume guarantee and had at least 12 hours of continuous detailed recording of ventilation variables...
June 21, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29925540/hypoxemic-and-hyperoxemic-likelihood-in-pulse-oximetry-ranges-nicu-observational-study
#3
Thomas E Bachman, Christopher J L Newth, Narayan P Iyer, Patrick A Ross, Robinder G Khemani
OBJECTIVE: Describe the likelihood of hypoxemia and hyperoxemia across ranges of oxygen saturation (SpO2 ), during mechanical ventilation with supplemental oxygenation. DESIGN: Retrospective observational study. SETTING: University affiliated tertiary care neonatal intensive care unit. PATIENTS: Two groups of neonates based on postmenstrual age (PMA): <32 weeks (n=104) and >36 weeks (n=709). MAIN MEASURES: Hypoxemia was defined as a PaO2 <40 mm Hg, hyperoxemia as a PaO2 of >99 mm Hg and normoxemia as a PaO2 of 50-80 mm Hg...
June 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29923109/current-challenges-in-neonatal-resuscitation-what-is-the-role-of-adrenaline
#4
REVIEW
Roberto Antonucci, Luca Antonucci, Cristian Locci, Annalisa Porcella, Laura Cuzzolin
Adrenaline, also known as epinephrine, is a hormone, neurotransmitter, and medication. It is the best established drug in neonatal resuscitation, but only weak evidence supports current recommendations for its use. Furthermore, the available evidence is partly based on extrapolations from adult studies, and this introduces further uncertainty, especially when considering the unique physiological characteristics of newly born infants. The timing, dose, and route of administration of adrenaline are still debated, even though this medication has been used in neonatal resuscitation for a long time...
June 19, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29910496/feeding-obturator-as-an-airway-adjunct-during-complete-unilateral-cleft-palate-repair
#5
Moustafa Abdelaziz Moustafa, Alaa Abdelrahman Kandeel, Ahmed M A Habib, Shady A Hassan
Background and Aims: The palatal defect and abnormal dentition in cleft palate make mask ventilation and laryngoscopy difficult. This study aimed to assess the effect of feeding obturator on laryngeal view in unilateral complete cleft palate. Methods: Ninety non-syndromic infants scheduled for the first stage correction of complete unilateral cleft palate were randomised to Group A (no feeding obturator) or Group B (obturator used for induction and intubation). The primary objective was to assess effect of the feeding obturator on the Cormack-Lehane grade on laryngoscopy...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29910465/neural-breathing-patterns-in-preterm-newborns-supported-with-non-invasive-neurally-adjusted-ventilatory-assist
#6
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, Gloria Galán Henríquez, Sonia Rivero Rodríguez, Alberto Hernández Gómez
OBJECTIVE: To characterize the neural breathing pattern in preterm infants supported with non-invasive neurally adjusted ventilatory assist (NIV-NAVA). STUDY DESIGN: Single-center prospective observational study. The electrical activity of the diaphragm (EAdi) was periodically recorded in 30-second series with the Edi catheter and the Servo-n software (Maquet, Solna, Sweden) in preterm infants supported with NIV-NAVA. The EAdiPeak , EAdiMin , EAdiTonic , EAdiPhasic , neural inspiratory, and expiratory times (nTi and nTe) and the neural respiratory rate (nRR) were calculated...
June 18, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29907849/does-prolonged-severe-hypercapnia-interfere-with-normal-cerebrovascular-function-in-piglets
#7
Massroor Pourcyrous, Sandeep Chilakala, Mohamad T Elabiad, Helena Parfenova, Charles W Leffler
BACKGROUND: Hypercapnia causes cerebral vasodilation and increased cerebral blood flow (CBF). During prolonged hypercapnia it is unknown whether cerebral vasodilation persists and whether cerebrovascular function is preserved. We investigated the effects of prolonged severe hypercapnia on pial arteriolar diameters (PAD) and cerebrovascular reactivity to vasodilators and vasoconstrictors. METHODS: Piglets were anesthetized, intubated and ventilated. Closed cranial windows were implanted to measure PAD...
May 28, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29907664/ventilation-inhomogeneity-in-infants-with-recurrent-wheezing
#8
Zihang Lu, Rachel E Foong, Krzysztof Kowalik, Theo J Moraes, Ayanna Boyce, Aimee Dubeau, Susan Balkovec, Per Magnus Gustafsson, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Wendy Lou, Felix Ratjen, Malcolm Sears, Padmaja Subbarao
BACKGROUND: The care of infants with recurrent wheezing relies largely on clinical assessment. The lung clearance index (LCI), a measure of ventilation inhomogeneity, is a sensitive marker of early airway disease in children with cystic fibrosis, but its utility has not been explored in infants with recurrent wheezing. OBJECTIVE: To assess ventilation inhomogeneity using LCI among infants with a history of recurrent wheezing compared with healthy controls. METHODS: This is a case-control study, including 37 infants with recurrent wheezing recruited from outpatient clinics, and 113 healthy infants from a longitudinal birth cohort, the Canadian Healthy Infant Longitudinal Development study...
June 15, 2018: Thorax
https://www.readbyqxmd.com/read/29903033/treatment-of-giant-cervico-mediastinal-lymphatic-malformations-a-case-series
#9
So-Hyun Nam, Kyoung-Ah Kwon
BACKGROUND: Lymphatic malformations are histologically benign vascular structures that vary in anatomic lesion and size. Extensive head and neck lymphatic malformations may be life-threatening. In the present study, we described three difficult-to-treat infants with giant cervico-mediastinal lymphatic malformations accompanied by severe respiratory distress. CASE PRESENTATIONS: Case 1. A Korean girl born at a gestational age of 37 weeks and weighing 2920 g had a large cervical mass compressing the trachea...
June 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29902195/theoretical-open-loop-model-of-respiratory-mechanics-in-the-extremely-preterm-infant
#10
Laura Ellwein Fix, Joseph Khoury, Russell R Moores, Lauren Linkous, Matthew Brandes, Henry J Rozycki
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to their markedly increased chest wall compliance that does not provide enough structure against which the forces of inhalation can generate sufficient pressure. To address the continued challenge of studying treatments in this fragile population, we developed a nonlinear lumped-parameter respiratory system mechanics model of the extremely preterm infant that incorporates nonlinear lung and chest wall compliances and lung volume parameters tuned to this population...
2018: PloS One
https://www.readbyqxmd.com/read/29898763/non-invasive-high-frequency-oscillatory-ventilation-versus-nasal-continuous-positive-airway-pressure-in-preterm-infants-with-respiratory-distress-syndrome-study-protocol-for-a-multi-center-prospective-randomized-controlled-trial
#11
Xing-Wang Zhu, Yuan Shi, Li-Ping Shi, Ling Liu, Jiang Xue, Rangasamy Ramanathan
BACKGROUND: Invasive mechanical ventilation (IMV) is associated with the development of adverse pulmonary and non-pulmonary outcomes in very premature infants. Various modes of non-invasive respiratory support are increasingly being used to decrease the incidence of bronchopulmonary dysplasia. The aim of this trial is to compare the effect of non-invasive high-frequency oscillatory ventilation (NHFOV) and nasal continuous positive airway pressure (NCPAP) in preterm infants with respiratory distress syndrome (RDS) as a primary non-invasive ventilation support mode...
June 14, 2018: Trials
https://www.readbyqxmd.com/read/29897161/pressure-ulcers-incidence-preventive-measures-and-risk-factors-in-neonatal-intensive-care-and-intermediate-care-units
#12
Pablo García-Molina, Evelin Balaguer-López, Francisco Pedro García-Fernández, María de Los Ángeles Ferrera-Fernández, José María Blasco, José Verdú
Epidemiological studies on pressure ulcers (PUs) in hospitalised infants are scarce. Spain lacks comprehensive research studies providing data on the prevalence or incidence in this population. This work was developed to determine the incidence of PUs in hospitalised infants admitted to intensive and intermediate care units, along with relevant risk factors and preventive measures. A prospective study appraising the incidence of PUs in infants was performed. The risk factors and preventive measures were evaluated using a multivariate logistic regression model...
June 13, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29895840/altered-metabolites-in-newborns-with-persistent-pulmonary-hypertension
#13
Martina A Steurer, Scott Oltman, Rebecca J Baer, Sky Feuer, Liang Liang, Randi A Paynter, Larry Rand, Kelli K Ryckman, Roberta L Keller, Laura L Jelliffe-Pawlowski
BACKGROUND: There is an emerging evidence that pulmonary hypertension is associated with amino acid, carnitine, and thyroid hormone aberrations. We aimed to characterize metabolic profiles measured by the newborn screen (NBS) in infants with persistent pulmonary hypertension of the newborn (PPHN) METHODS: Nested case-control study from population-based database. Cases were infants with ICD-9 code for PPHN receiving mechanical ventilation. Controls receiving mechanical ventilation were matched 2:1 for gestational age, sex, birth weight, parenteral nutrition administration, and age at NBS collection...
June 12, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29895572/pulseless-electrical-activity-a-misdiagnosed-entity-during-asphyxia-in-newborn-infants
#14
Sparsh Patel, Po-Yin Cheung, Anne Lee Solevåg, Keith J Barrington, C Omar Farouk Kamlin, Peter G Davis, Georg M Schmölzer
BACKGROUND: The 2015 neonatal resuscitation guidelines added ECG as a recommended method of assessment of an infant's heart rate (HR) when determining the need for resuscitation at birth. However, a recent case report raised concerns about this technique in the delivery room. OBJECTIVES: To compare accuracy of ECG with auscultation to assess asystole in asphyxiated piglets. METHODS: Neonatal piglets had the right common carotid artery exposed and enclosed with a real-time ultrasonic flow probe and HR was continuously measured and recorded using ECG...
June 12, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29894475/neonatal-factors-related-to-center-variation-in-the-incidence-of-late-onset-circulatory-collapse-in-extremely-preterm-infants
#15
Yume Suzuki, Yumi Kono, Takahiro Hayakawa, Hironori Shimozawa, Miyuki Matano, Yukari Yada
BACKGROUND: Although late-onset circulatory collapse (LCC) is widely recognized in Japan, its etiology and the reason for center variation in its incidence remain unclear. This study's objectives were to identify the perinatal and neonatal factors related to LCC and to estimate the factors related to the center variation in the incidence of LCC. METHODS: Extremely preterm infants born between 2008 and 2012 who were registered in the database of the Neonatal Research Network, Japan were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29894309/torso-shape-detection-to-improve-lung-monitoring
#16
Serena de Gelidi, Nima Seifnaraghi, Andy Bardill, Andrew Tizzard, Yu Wu, Erich Sorantin, Sven Nordebo, Andreas Demosthenous, Richard H Bayford
Newborns with lung immaturity often require continuous monitoring and treatment of their lung ventilation in intensive care units, especially if born preterm. Recent studies indicate that Electrical Impedance Tomography (EIT) is feasible in newborn&#13; infants and children, and can quantitatively identify changes in regional lung aeration and ventilation following alterations to respiratory conditions. Information on the patient-specic shape of the torso and its role in minimizing the artefacts in the&#13; reconstructed images can improve the accuracy of the clinical parameters obtained from EIT...
June 12, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29894205/elafin-treatment-rescues-egfr-klf4-signaling-and-lung-cell-survival-in-ventilated-newborn-mice
#17
Miguel A Alejandre Alcazar, Mark Kaschwich, Robert Ertsey, Stefanie Preuss, Carlos Milla, Sana Mujahid, Juliet Masumi, Suleman Khan, Lucia M Mokres, Lu Tian, Jasmine Mohr, Dharmesh V Hirani, Marlene Rabinovitch, Richard D Bland
RATIONALE: Mechanical ventilation with O2 -rich gas (MV-O2 ) inhibits alveologenesis and lung growth. We showed that MV-O2 increases elastase activity and apoptosis in lungs of newborn mice; elastase inhibition by elafin suppressed apoptosis and enabled lung growth. In pilot studies, MV-O2 reduced lung expression of pro-survival factors, pEGFR and Klf4. OBJECTIVES: Determine if apoptosis and lung growth arrest evoked by MV-O2 reflect disrupted pEGFR-Klf4 signaling, which elafin treatment preserves...
June 12, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29889001/the-mean-airway-pressure-may-be-the-answer
#18
Luis Perez-Baena, Martí Pons-Òdena
Altough the literature data and meta-analysis reported that NIV strategies, nasal intermittent positive pressure ventilation (N-IPPV) and Bi-level-NCPAP (BiPAP), has a better respiratory outcome than n-CPAP in neonatal respiratory distress syndrome, it is possible that the interpretation is not entirely accurate. Salvo et al. found that the incidence of NIV failure was significantly higher in the N-CPAP group versus N-SIPPV/BiPAP groups in infants with RDS. Nevertheless MAP was significantly higher in N-SIPPV group when compared to N-CPAP and BiPAP group (p < 0,05 in both) and MAP in the BiPAP group was significantly higher than N-CPAP group (p < 0,05)...
June 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29887608/early-diastolic-dysfunction-and-respiratory-morbidity-in-premature-infants-an-observational-study
#19
Neidin Bussmann, Colm Breatnach, Philip T Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash
OBJECTIVE: To test if diastolic dysfunction measured on day one of age is associated with the need for invasive ventilation in preterm infants. STUDY DESIGN: We conducted a retrospective observational tissue Doppler echocardiographic study over the first 12 h of age for infants born <32 weeks who were invasively ventilated, and infants on continuous positive pressure ventilation (CPAP). RESULTS: One hundred and eighty-three infants were included (27 ± 2 weeks and 999 ± 296 g)...
June 11, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29885776/early-energy-and-protein-intakes-and-associations-with-growth-bpd-and-rop-in-extremely-preterm-infants
#20
Susanna Klevebro, Vera Westin, Elisabeth Stoltz Sjöström, Mikael Norman, Magnus Domellöf, Anna-Karin Edstedt Bonamy, Boubou Hallberg
BACKGROUND & AIM: Extremely preterm infants face substantial neonatal morbidity. Nutrition is important to promote optimal growth and organ development in order to reduce late neonatal complications. The aim of this study was to examine the associations of early nutritional intakes on growth and risks of bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in a high-risk population. METHODS: This population-based cohort study includes infants born before 27 0/7 weeks of gestational age without severe malformations and surviving ≥10 days...
May 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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