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https://www.readbyqxmd.com/read/27834728/graft-versus-self-gvs-against-t-cell-autoantigens-is-a-mechanism-of-graft-host-interaction
#1
Nora Mirza, Manfred Zierhut, Andreas Korn, Antje Bornemann, Wichard Vogel, Barbara Schmid-Horch, Wolfgang A Bethge, Stefan Stevanović, Helmut R Salih, Lothar Kanz, Hans-Georg Rammensee, Sebastian P Haen
Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self)...
November 10, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27818317/assessment-of-dry-eye-in-a-gvhd-murine-model-approximation-through-tear-osmolarity-measurement
#2
Rafael Martínez-Carrasco, Luis Ignacio Sánchez-Abarca, Cristina Nieto-Gómez, Elisabet Martín García, Teresa L Ramos, Almudena Velasco, Fermín Sánchez-Guijo, José Aijón, Emiliano Hernández-Galilea
Dry eye disease is one of the most frequent pathological events that take place in the course of the graft versus host disease (GVHD), and is the main cause of deterioration in quality of life for patients. Thus, demonstration of dry eye signs in murine models of oGVHD is crucial for the validation of these models for the study of the disease. Given the increasing evidence that tear osmolarity is an important player of dry eye disease, our purpose in this study was to validate the use of a reliable method to assess tear osmolarity in mice: the electrical impedance method...
November 3, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27607414/in-vivo-confocal-microscopy-in-dry-eye-disease-associated-with-chronic-graft-versus-host-disease
#3
Ahmad Kheirkhah, Yureeda Qazi, Michael A Arnoldner, Kunal Suri, Reza Dana
PURPOSE: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host disease (GVHD) using in vivo confocal microscopy (IVCM). METHODS: This study included 54 patients who had moderate to severe DED either associated with (n = 33) or without (n = 21) chronic GVHD. In addition to evaluating clinical parameters of DED, images obtained by laser-scanning IVCM of the central cornea and superior tarsal conjunctiva were analyzed to measure densities of corneal epithelial DCs, corneal subbasal nerves, and conjunctival EICs...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27595285/long-term-safety-and-efficacy-of-autologous-platelet-lysate-drops-for-treatment-of-ocular-gvhd
#4
S Pezzotta, C Del Fante, L Scudeller, G C Rossi, C Perotti, P E Bianchi, E Antoniazzi
Current ocular GvHD (oGvHD) treatments are suboptimal. We investigated the safety and efficacy of long-term continuous treatment with autologous platelet lysate (PL) drops in patients with oGvHD Dry Eye Syndrome (DES) score 2-3 refractory to topical conventional therapy. Ophthalmic evaluation was performed at 6 month intervals. Symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were defined 'responders' when showing a reduction at least one grade on National Institutes of Health Eye Score from baseline at the 6 month visit...
September 5, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27567559/prgf-exerts-more-potent-proliferative-and-anti-inflammatory-effects-than-autologous-serum-on-a-cell-culture-inflammatory-model
#5
E Anitua, F Muruzabal, M de la Fuente, A Riestra, J Merayo-Lloves, G Orive
Ocular graft versus host disease (oGVHD) is part of a systemic inflammatory disease that usually affects ocular surface tissues manifesting as a dry eye syndrome. Current treatments provide unsatisfactory results. Blood-derived products, like plasma rich in growth factors (PRGF) emerge as a potential therapy for this disease. The purpose of this study was to evaluate the tissue regeneration and anti-inflammatory capability of PRGF, an autologous platelet enriched plasma eye-drop, compared to autologous serum (AS) obtained from oGVHD patients on ocular surface cells cultured in a pro-inflammatory environment...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27492793/novel-scoring-criteria-for-the-evaluation-of-ocular-graft-versus-host-disease-in-a-preclinical-allogeneic-hematopoietic-stem-cell-transplantation-animal-model
#6
Victor L Perez, Alexander Barsam, Stephanie Duffort, Maitee Urbieta, Henry Barreras, Casey Lightbourn, Krishna V Komanduri, Robert B Levy
Ocular complications occur after transplantation in 60% to 90% of chronic graft-versus-host disease (GVHD) patients and significantly impair vision-related quality of life. Ocular surface inflammation and dry eye disease are the most common manifestations of ocular GVHD. Ocular GVHD can be viewed as an excellent preclinical model that can be studied to understand the immune pathogenesis of this common and debilitating disease. A limitation of this is that only a few experimental models mimic the ocular complications after hematopoietic stem cell transplantation (HSCT) and have focused on the acute GVHD process...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27380960/safety-and-efficacy-of-autologous-serum-eye-drop-for-treatment-of-dry-eyes-in-graft-versus-host-disease
#7
Amir A Azari, Remzi Karadag, Mozhgan Rezaei Kanavi, Sarah Nehls, Neal Barney, Kyungmann Kim, Walter Longo, Peiman Hematti, Mark Juckett
PURPOSE: To evaluate the treatment of autologous serum eye drops (ASED) on dry eyes in patients with graft-versus-host disease (GVHD). METHODS: A retrospective chart review of 35 patients with a history of ocular GVHD following hematopoietic stem cell transplantation that used ASED to alleviate dry eye symptoms was performed. Patients were categorized into three different groups. If patients had available ophthalmic data before and after starting treatment was group 1 (n = 14), had available ophthalmic data after starting treatment in group 2 (n = 10) and had available ophthalmic data before treatment or did not have any data after starting treatment in group 3 (n = 11)...
July 22, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27373389/cataract-surgery-in-patients-with-chronic-severe-graft-versus-host-disease
#8
Ankit Shah, Marcony R Santhiago, Edgar M Espana
PURPOSE: To evaluate the surgical outcomes of cataract extraction with phacoemulsification and intraocular lens implantation in patients with severe chronic ocular graft-versus-host disease (GVHD). SETTING: University of South Florida Eye Institute, Tampa, Florida, USA. DESIGN: Retrospective case study. METHODS: A chart review was performed to identify patients with clinically severe, biopsy-proven chronic ocular GVHD who had cataract extraction...
June 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27267447/treatment-of-severe-chronic-ocular-graft-versus-host-disease-using-100-autologous-serum-eye-drops-from-a-sealed-manufacturing-system-a-retrospective-cohort-study
#9
Volkan Tahmaz, Uta Gehlsen, Laura Sauerbier, Udo Holtick, Lisa Engel, Stela Radojska, Viorica-Maria Petrescu-Jipa, Christof Scheid, Michael Hallek, Birgit Gathof, Claus Cursiefen, Philipp Steven
BACKGROUND/AIMS: To analyse patients with chronic ocular graft-versus-host disease (GvHD) under treatment with 100% autologous serum eye drops from a sealed manufacturing system. METHODS: 17 patients with chronic ocular GvHD received 100% autologous serum eye drops from single use vials manufactured in a sealed system. Retrospective analysis included visual acuity, corneal staining, frequency of artificial tears, ocular symptoms by means of a questionnaire and information on subjective side effects and cost compensation...
June 6, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27198497/graft-versus-host-disease-in-paediatric-solid-organ-transplantation-a-review-of-the-literature
#10
REVIEW
Thomas Green, Jonathan Hind
GvHD is a rare and serious complication of organ transplantation. The literature is sparse following solid organ transplantation. The aim of this report was to review the literature of GvHD in paediatric solid organ transplantation. We searched PubMed for English-language full-text manuscripts between 1990 and 2015 for eligible studies. A total of 28 publications were found pertaining to paediatric GvHD following solid organ transplantation. GvHD had a mean incidence of 11% (range 8.3-13.4%) following SBTx and 1...
August 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27195094/recurrent-corneal-perforation-due-to-chronic-graft-versus-host-disease-a-clinicopathologic-report
#11
Mehrdad Mohammadpour, Siamak Maleki, Hassan Hashemi, Amir Houshang Beheshtnejad
PURPOSE: To describe a case of chronic graft versus host disease (GVHD) leading to severe dry eye and recurrent corneal perforation in both eyes, its stepwise management and histopathological reports. CASE REPORT: A 22-year-old woman with a history of thalassemia and subsequent high-dose chemotherapy followed by allogeneic bone marrow transplant (BMT) was referred to Farabi Eye Hospital. Despite aggressive medical and surgical intervention, corneal vascularization in her right eye progressed and led to corneal perforation...
January 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27086024/a-clinical-trial-comparing-the-safety-and-efficacy-of-topical-tacrolimus-versus-methylprednisolone-in-ocular-graft-versus-host-disease
#12
Tulio B Abud, Francisco Amparo, Ujwala S Saboo, Antonio Di Zazzo, Thomas H Dohlman, Joseph B Ciolino, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate the safety and efficacy of topical tacrolimus 0.05% versus topical methylprednisolone 0.5% in patients with ocular graft-versus-host disease (GVHD). DESIGN: Phase 1/2 prospective, randomized, double-masked clinical trial. PARTICIPANTS: Eighty eyes of 40 patients diagnosed with chronic ocular GVHD were enrolled. METHODS: Forty patients with ocular GVHD were randomized; 24 patients were treated with topical tacrolimus 0...
July 2016: Ophthalmology
https://www.readbyqxmd.com/read/26968719/prevalence-of-ocular-hypertension-and-glaucoma-in-patients-with-chronic-ocular-graft-versus-host-disease
#13
Ujwala S Saboo, Francisco Amparo, Hasanain Shikari, Reza Dana
PURPOSE: To evaluate the prevalence of ocular hypertension (OHT) and glaucoma in patients with chronic ocular graft-versus-host disease (GVHD). METHODS: We performed a retrospective chart review of 218 patients diagnosed with chronic ocular GVHD. Ocular hypertension was defined as intraocular pressure (IOP) ≥ 24 mmHg in either eye without any glaucomatous optic disc changes. Glaucoma suspect was defined as optic disc changes with a cup-to-disc ratio ≥ 0...
May 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/26927568/biomarkers-in-ocular-chronic-graft-versus-host-disease-tear-cytokine-and-chemokine-based-predictive-model
#14
Lidia Cocho, Itziar Fernández, Margarita Calonge, Verónica Martínez, María J González-García, Dolores Caballero, Lucía López-Corral, Carmen García-Vázquez, Lourdes Vázquez, Michael E Stern, Amalia Enríquez-de-Salamanca
PURPOSE: To develop a tear molecule level-based predictive model based on a panel of tear cytokines and their correlation with clinical features in ocular chronic graft versus host disease (cGVHD). METHODS: Twenty-two ocular cGVHD patients and 21 healthy subjects were evaluated in a controlled environmental research laboratory (CERLab). Clinical parameters were recorded, and tears were collected. Levels of 15 molecules (epidermal growth factor [EGF], IL receptor antagonist [IL-1Ra], IL-1β, IL-2, IL-6, IL-8/CXCL8, IL-10, IL-12p70, IL-17A, interferon inducible protein [IP]-10/CXCL10, IFN-γ, VEGF, TNF-α, eotaxin 1, and regulated on activation normal T cell expressed and secreted [RANTES]) were measured by multiplex-bead assay and correlated with clinical parameters...
February 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26808567/conjunctival-polyploid-cells-and-donor-derived-myofibroblasts-in-ocular-gvhd
#15
D Hallberg, K Stenberg, C Hanson, U Stenevi, M Brune
After allogeneic hematopoietic stem cell transplantation (allo-SCT), ocular GvHD is a common complication, typical symptoms being dry eye syndrome with features of fibrosis. In this study, we have identified and quantified two cell types-myofibroblasts (MFB) and polyploid (PP) cells-in the conjunctival surface of allo-SCT patients (pts) and have explored their kinetics and association with local and systemic GvHD. Results are compared with control groups of (a) pretransplant samples from allo-SCT patients, (b) recipients of autologous transplantation (auto-SCT) and (c) healthy controls...
May 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/26659079/verification-of-the-new-grading-scale-for-ocular-chronic-graft-versus-host-disease-developed-by-the-german-austrian-swiss-consensus-conference-on-chronic-gvhd
#16
Christiane Blecha, Daniel Wolff, Barbara Holler, Ernst Holler, Daniela Weber, Regine Vogt, Horst Helbig, Tina Dietrich-Ntoukas
The purpose of the study was to validate a recently proposed new grading system for ocular manifestations of chronic graft-versus-host disease (cGVHD). Diagnosis of cGVHD was based on the NIH consensus criteria. In addition, a grading scale was applied, which has been developed by the German-Austrian-Swiss Consensus Conference on Clinical Practice in cGVHD. Sixty-six patients (male n = 46, female n = 20, mean age 48 years) with ocular cGVHD were included. Application of the proposed Consensus Conference grading revealed inflammatory activity in all patients with mild (33 %), moderate (44 %), or severe inflammation (23 %)...
February 2016: Annals of Hematology
https://www.readbyqxmd.com/read/26658588/ocular-graft-versus-host-disease-in-allogenic-haematopoetic-stem-cell-transplantation-in-a-tertiary-care-centre-in-india
#17
Rehan Khan, Sridevi Nair, Tullika Seth, Pravas Mishra, Manoranjan Mahapatra, Tushar Agarwal, Radhika Tandon, Murugesan Vanathi
BACKGROUND & OBJECTIVES: This study was aimed to report the occurrence of ocular graft versus host disease (oGVHD) in allogeneic haematopoietic stem cell transplantation (allo-HSCT) patients in a tertiary care hospital setting. METHODS: A cross-sectional study of ocular surface of allo-HSCT patients was done. Slit lamp biomicroscopy, symptom score, tear meniscus height, fluorescein tear break-up time, Schirmer's test I, ocular surface staining, dry eye severity, ocular surface disease index score were done...
November 2015: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/26651304/retinal-toxicity-of-high-dose-hydroxychloroquine-in-patients-with-chronic-graft-versus-host-disease
#18
Eduardo V Navajas, Hatem Krema, Dena S Hammoudi, Jeffrey H Lipton, E Rand Simpson, Shelley Boyd, Michael Easterbrook
OBJECTIVE: To evaluate retinal toxicity in patients treated with high-dose hydroxychloroquine (HCQ) (Plaquenil, Sanofi Pharmaceuticals) for chronic graft-versus-host disease (GVHD). DESIGN: Cohort study. PARTICIPANTS: Twelve patients with chronic GVHD treated with 800 mg/day HCQ between June 2005 and December 2010. METHODS: Patients in this study underwent ophthalmologic examination yearly and ancillary studies including colour vision, Amsler grid, fundus photographs, Humphrey 10-2 automated perimetry, spectral-domain optical coherence tomography (SD-OCT), and multifocal electroretinography (mfERG)...
December 2015: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/26602095/-ocular-graft-versus-host-disease
#19
T Dietrich-Ntoukas, P Steven
Ocular graft-versus-host disease (GvHD) is predominantly an inflammatory ocular surface disorder after allogeneic hematopoietic stem cell transplantation (HSCT) with increasing incidence. It is not only associated with reduced quality of life because of dry eye syndromes but can also impair visual acuity and lead to blindness due to corneal complications. The GvHD is mostly associated with severe moisturizing disorder of the ocular surface, which is often resistant to therapy and accompanied by chronic inflammation...
December 2015: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/26452109/retinal-involvement-in-a-patient-with-cerebral-manifestation-of-chronic-graft-versus-host-disease
#20
Christiane Blecha, Klemens Angstwurm, Daniel Wolff, Ernst Holler, Horst Helbig, Jochen Grassinger, Janine Rennert, Ingo Kleiter, Elisabeth Huber, Christoph Schmid, Tina Dietrich-Ntoukas
BACKGROUND: We report a 35-year-old female patient with cerebral manifestations of chronic graft-versus-host disease (cGvHD) and putative retinal involvement after allogeneic peripheral blood stem cell transplantation (alloHSCT). PATIENT AND METHODS: The patient experienced recurrent episodes of fever and encephalitic signs 7 months after alloHSCT during taper of immunosuppression (IS). RESULTS: Cerebral magnetic resonance imaging (MRI) showed non-gadolinium-enhancing confluent periventricular lesions and cerebrospinal fluid inflammation...
2015: Oncology Research and Treatment
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