keyword
MENU ▼
Read by QxMD icon Read
search

Dry eye disease

keyword
https://www.readbyqxmd.com/read/28638660/analysis-of-clinical-characteristics-of-immune-related-dry-eye
#1
Hua Wang, Ping-Bao Wang, Ting Chen, Jing Zou, Ya-Jia Li, Xu-Fang Ran, Qiang-Xiang Li
AIM: To discuss the clinical characteristics of immune-related dry eye. METHODS: Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren's syndrome (SS), 72 cases of systemic lupus erythematosus (SLE), and 65 cases of rheumatoid arthritis (RA). The classification of all patients was performed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28637904/ifn-%C3%AE-expressing-th17-cells-are-required-for-development-of-severe-ocular-surface-autoimmunity
#2
Yihe Chen, Sunil K Chauhan, Chunyi Shao, Masahiro Omoto, Takenori Inomata, Reza Dana
Th17 cells are critical effectors mediating the ocular surface autoimmunity in dry eye disease (DED). Increased IFN-γ has also been implicated in DED; however, it remains unclear to what extent Th1 cells contribute to DED pathogenesis. In this study, we investigated the cellular source of IFN-γ and assessed its contribution to corneal epitheliopathy in DED mice. We discovered a significant IL-17A(+)IFN-γ(+) (Th17/1) population and determined that these cells are derived from Th17 precursors. Adoptive transfer of Th17/1, but not Th1, cells confers the disease to naive recipients as effectively as do Th17 cells alone...
June 21, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28629694/interleukin-6-participation-in-pathology-of-ocular-diseases
#3
REVIEW
Forouhe Zahir-Jouzdani, Fatemeh Atyabi, Nazanin Mojtabavi
Interleukin-6 (IL-6) is a multifunctional cytokine that affects a variety of cells in the body such as osteoclasts, hepatocytes, endothelial cells, epithelial cells, white and red blood cells and etc. Elevated levels of IL-6 have been detected in many ocular diseases. Studies show that IL-6 has a major role in the pathology of glaucoma, CRVO, macular edema, ocular neovascularization, posterior capsule opacity formation, keratitis, dry eye disease, allergic eye disease, ocular autoimmune disease, corneal chemical burn, ocular inflammation and so on...
June 10, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28627956/evaluating-the-effects-of-botulinum-toxin-a-on-tear-metrics-in-patients-with-hemifacial-spasm
#4
Yasmin Poustchi Mali, Robert L Schultze, Edward J Wladis
Hemifacial spasm has been previously shown to result in dry eye and ocular surface diseases. This study was performed to assess the impact of chemodenervation with botulinum toxin on clinically-relevant metrics of tears. Tear osmolarity and lipid layer thickness were measured in patients with hemifacial spasm after they achieved relief from hemifacial spasm via botulinum toxin injections. Twelve eyes of 6 patients with hemifacial spasm (2 men and 4 women; mean age 55.5 years) were assessed in accordance with the Declaration of Helsinki and IRB approval...
June 19, 2017: Orbit
https://www.readbyqxmd.com/read/28622318/characteristics-of-symptoms-experienced-by-persons-with-dry-eye-disease-while-driving-in-china
#5
Y Wang, H Lv, Y Liu, X Jiang, M Zhang, X Li, W Wang
PurposeTo assess the vision-related quality of life and self-reported driving performance of patients with dry eye disease (DED).Patients and methodsThe study was performed in the eye centre of Peking University Third Hospital, China. In total, 87 dry eye patients and 42 controls were enroled, including 49 patients without any treatment (group A), 38 patients treated with artificial tears (group B) and 42 controls without DED (group C). The participants had no eye disease other than DED. Scores of a vision-related quality-of-life questionnaire (Ocular Surface Disease Index (OSDI)), a daily life-related visual function questionnaire and a questionnaire about performance during driving were collected...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28617532/the-effect-of-a-natural-standardized-bilberry-extract-mirtoselect%C3%A2-in-dry-eye-a-randomized-double-blinded-placebo-controlled-trial
#6
A Riva, S Togni, F Franceschi, S Kawada, Y Inaba, R Eggenhoffner, L Giacomelli
OBJECTIVE: Dry eye, a chronic disease of lachrymal fluid and corneo-conjunctival epithelium, could significantly impact visual function, affects quality of life and work productivity. Beside several conventional treatments, nutritional supplements based on bilberry extract have been identified as effective contributors to eye health. Here, we aim at investigating the bioavailability of a standardized bilberry extract, its ability to alleviate dry eye symptoms and its antioxidant potential...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28606267/-comparison-of-two-kinds-of-artificial-tears-on-the-dry-eye-after-phacoemulsification
#7
R You, J Wang, Y Han, L J Liu, W Y Wang
Objective: To compare the curative effect of two different artificial tears on dry eye after phacoemulsification. Methods: Prospective randomized controlled clinical trial. From March to June in 2012, 102 patients (102 eyes) with age-related cataract were treated with phacoemulsification at Beijing Tongren Hospital, Capital University of Medical Sciences, and these eyes were randomly divided into blank group (group A ) 32 cases, treatment group 1 (group B) 35 cases and treatment group 2 (group C) 35 cases. Group A was treated with conventional antibiotics...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28587435/effect-of-topical-rebamipide-on-goblet-cells-in-the-lid-wiper-of-human-conjunctiva
#8
Satoru Kase, Toshiya Shinohara, Manabu Kase, Susumu Ishida
It has been demonstrated that topical administration of rebamipide, which is an antiulcer agent, increases the mucin level of the tear film and ameliorates ocular surface conditions such as lid wiper epitheliopathy. The aim of the present study was to analyze the changes in goblet cell number, cell proliferation, and epidermal growth factor receptor (EGFR) induced by topical rebamipide addition to the lid wiper of humans. A total of 30 eyelid tissue samples were obtained during involutional entropion surgeries, fixed in paraformaldehyde, embedded in paraffin and divided into two groups: Rebamipide or non-rebamipide...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28587370/a-novel-noninvasive-ocular-surface-analyzer-for-the-assessment-of-dry-eye-with-meibomian-gland-dysfunction
#9
Yuanyuan Qi, Chen Zhang, Shaozhen Zhao, Yue Huang, Ruibo Yang
Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28587293/pathological-analysis-of-ocular-lesions-in-a-murine-model-of-sj%C3%A3-gren-s-syndrome
#10
Aya Ushio, Rieko Arakaki, Hiroshi Eguchi, Fumika Hotta, Akiko Yamada, Yasusei Kudo, Naozumi Ishimaru
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by severe inflammation of exocrine glands such as the salivary and lacrimal glands. When it affects the lacrimal glands, many patients experience keratoconjunctivitis due to severely dry eyes. This study investigated the pathological and immunological characteristics of ocular lesions in a mouse model of SS. Corneal epithelial injury and hyperplasia were confirmed pathologically. The number of conjunctival mucin-producing goblet cells was significantly decreased in the SS model mice compared with control mice...
June 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28586929/-keratoprosthesis-with-biological-haptic-the-d%C3%A3-sseldorf-offenburg-experience-with-osteo-odonto-and-tibia-keratoprosthesis
#11
Gerd Geerling, Konrad Hille
In severe ocular surface disease with limbal stem cell deficiency associated with severe dry eye, penetrating keratoplasty is likely to fail. In these cases, and provided the posterior segment is normal, keratoprosthesis surgery (KPro) can achieve visual rehabilitation. In KPros with an autologous biological haptic, a bone-tooth-complex (osteo-odonto-keratoprothesis, OOKPro) or a piece of tibial cortex (tibia-keratoprosthesis, TKPro) is used to carry a PMMA cylinder. This construct can successfully be implanted even in severely dry eyes and in those with autoimmune disease, in which other KPro designs frequently fail...
June 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28585267/intense-pulsed-light-treatment-and-meibomian-gland-expression-for-moderate-to-advanced-meibomian-gland-dysfunction
#12
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This single-institution, open-label prospective study involved 26 participants who received bilateral treatments using a proprietary intense pulsed light device (E > Eye, E-Swin, Paris, France) combined with therapeutic meibomian gland expression at baseline, Week 2 and Week 6...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28585260/randomised-controlled-trial-of-topical-antibacterial-manuka-leptospermum-species-honey-for-evaporative-dry-eye-due-to-meibomian-gland-dysfunction
#13
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of standardised Manuka (Leptospermum species) antibacterial honey as adjunctive twice daily treatment to conventional therapy (warm compresses, lid massage and preservative-free lubricant), in participants with evaporative dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This prospective, open-label study involved 114 participants. After two weeks of conventional therapy participants were randomised to one of three treatment groups: Optimel Antibacterial Manuka Eye Gel (98 per cent Leptospermum species honey) plus conventional therapy (n = 37), Optimel Manuka plus Lubricant Eye Drops (16 per cent Leptospermum species honey) plus conventional therapy (n = 37) and a control (conventional therapy) (n = 40)...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28579745/lifitegrast-ophthalmic-solution-in-the-treatment-of-signs-and-symptoms-of-dry-eye-disease-design-development-and-place-in-therapy
#14
REVIEW
Morgan R Godin, Preeya K Gupta
A new topical ophthalmic medication, lifitegrast 5%, was recently approved by the US Food and Drug Administration for use in dry eye patients. Lifitegrast is an integrin antagonist that decreases inflammation on the ocular surface, thereby improving dry eye disease (DED). Through a series of prospective, multicenter, randomized, masked, placebo-controlled studies in >2,000 patients total, lifitegrast was shown to be effective for improvement in both the signs and symptoms of DED. A subsequent study focused on the safety profile of lifitegrast and demonstrated that the majority of adverse events were mild and resolved over time...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28579744/randomized-comparison-of-in-vivo-performance-of-two-point-of-care-tear-film-osmometers
#15
Jerry Nolfi, Barbara Caffery
PURPOSE: To compare the in vivo precision of two commercially available point-of-care osmometers among normal subjects with no dry eye disease. METHODS: Twenty healthy adults with healthy ocular surfaces were evaluated by licensed eye care practitioners. All subjects had low Ocular Surface Disease Index score (<5), normal tear breakup time (>10 seconds), and no evidence of corneal fluorescein staining. Five consecutive measurements of tear osmolarity were measured on each eye using each of the two osmometers: the TearLab Osmolarity System (TearLab) and the I-Med i-Pen (i-Pen), for a total of 200 measurements per device...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28576215/effect-of-dry-eye-on-scheimpflug-imaging-of-the-cornea-and-elevation-data
#16
Leyla Asena, Dilek D Altınörs, Şefik Cezairlioğlu, Sefer Ogün Bölük
OBJECTIVE: To evaluate the effect of dry eye on Scheimpflug imaging of the cornea and elevation data. DESIGN: Prospective observational study. PARTICIPANTS: Scheimpflug images of 50 patients with dry eye who were being tested for eligibility for corneal refractive surgery were screened. Twelve eyes of 12 patients with abnormal Belin/Ambrosio enhanced ectasia display (BAD) anterior elevation difference were included in the study. The patients had no history of contact lens wear or any other sign of ectasia...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28565934/aceclofenac-oil-drops-characterization-and-evaluation-against-ocular-inflammation
#17
Rajesh Katara, Sameer Sachdeva, Dipak K Majumdar
Ocular inflammatory diseases, such as uveitis, scleritis, episcleritis, and dry eye syndrome are commonly treated with eye drop formulations. In the present study, attempts were made to prepare aceclofenac oil formulations to evaluate its transcorneal permeation and anti-inflammatory effect. Ophthalmic solutions of aceclofenac with or without (0.5% v/v) benzyl alcohol were formulated in different vegetable oils and permeation studies were carried out. Aceclofenac ophthalmic solution in linseed oil containing benzyl alcohol exhibited maximum permeation (4...
June 1, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28559720/magnitude-of-diabetes-and-hypertension-among-patients-with-dry-eye-syndrome-at-a-tertiary-hospital-of-riyadh-saudi-arabia-a-case-series
#18
Abdullah Omar Al Houssien, Rana Omar Al Houssien, Abdulaziz Al-Hawass
PURPOSE: To study the magnitude of chronic diseases among patients suffering from Dry Eye Syndrome (DES) and compare them with published findings in the literature. METHODS: Patients diagnosed in 2016 suffering from DES based on presenting symptoms and findings of ocular examination were included in this study. The demographic information included age and gender. Chronic diseases among them were identified through case records, assessment and ongoing medications...
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28555041/the-effect-of-dry-eye-disease-on-scar-formation-in-rabbit-glaucoma-filtration-surgery
#19
Hong Ji, Yingting Zhu, Yingying Zhang, Yu Jia, Yiqing Li, Jian Ge, Yehong Zhuo
The success rate of glaucoma filtration surgery is closely related to conjunctival inflammation, and the main mechanism of dry eye disease (DED) is inflammation. The aim of this study was to evaluate the effect of DED on bleb scar formation after rabbit glaucoma filtration surgery. Sixteen New Zealand white rabbits were randomly divided into control and DED groups. A DED model was induced by twice-daily topical administration of 0.1% benzalkonium chloride (BAC) drops for three weeks. Ocular examinations were performed to verify the DED model...
May 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28553560/optical-coherence-tomography-reveals-changes-to-corneal-reflectivity-and-thickness-in-individuals-with-tear-hyperosmolarity
#20
Laura Adelaide Deinema, Algis Jonas Vingrys, Holly Rose Chinnery, Laura Elizabeth Downie
PURPOSE: To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS: This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-osmolar tears). Symptoms and signs of DED (tear osmolarity, sodium fluorescein tear break-up time, ocular surface staining, Schirmer test) were assessed...
May 2017: Translational Vision Science & Technology
keyword
keyword
38375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"