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Dry eye disease

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https://www.readbyqxmd.com/read/29452970/effect-of-tear-supplements-on-signs-symptoms-and-inflammatory-markers-in-dry-eye
#1
Eilidh Martin, Katherine M Oliver, E Ian Pearce, Alan Tomlinson, Peter Simmons, Suzanne Hagan
PURPOSE: Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. METHODS: In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At each visit, symptoms, tear evaporation rate, stability and osmolarity were measured and tear samples were analyzed for 7 inflammatory markers, using multiplex immunoassays...
February 13, 2018: Cytokine
https://www.readbyqxmd.com/read/29452534/co-culture-of-human-bone-marrow-mesenchymal-stem-cells-and-macrophages-attenuates-lipopolysaccharide-induced-inflammation-in-human-corneal-epithelial-cells
#2
Won-Yong Jeong, Ji-Hye Kim, Chan-Wha Kim
Dry eye syndrome (DES) is considered as an ocular surface inflammatory disease. Previous studies have shown inflammation plays an important role in the progression and onset of DES. Co-culture of human bone marrow mesenchymal stem cells (HBMSCs) and macrophages showed immunomodulatory effects via regulation of cytokine regulation. Thus, the aim of this study was to investigate the effect of the interaction of these cells on in vitro DES model. The conditioned media (CM) from macrophages, HBMSCs, and HBMSCs + macrophages were treated to human corneal epithelial cells, which showed significant reduction in IL-1α and IL-1β expression levels in HBMSCs + macrophages group...
February 16, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29452004/review-of-literature-on-measurements-of-non-invasive-break-up-times-lipid-morphology-and-tear-meniscal-height-using-commercially-available-hand-held-instruments
#3
Louis Tong, Lim Shee Teng
Purpose/aims: Dry eye is a common multi-factorial disease characterized by tearfilm dysfunction. Diagnosis of dry eye requires documentation of tear status with non-invasive tear break up times (NIBUT), tear meniscal height (TMH), and tearfilm lipid layer. These parameters objectively assess tear stability and indirectly, the functional impact of meibomian gland dysfunction. While it is obvious that portable instrumentation gives broader access than fixed instrumentation, its value would be limited if it is unreliable and its precision and accuracy substantially worse than fixed instruments...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29449499/clinical-correlates-outcomes-and-predictors-of-inflammatory-ocular-disease-associated-with-rheumatoid-arthritis-in-the-biologic-era
#4
Cristian Caimmi, Cynthia S Crowson, Wendy M Smith, Eric L Matteson, Ashima Makol
OBJECTIVE: Inflammatory ocular disease (IOD) is a rare but severe extraarticular manifestation of rheumatoid arthritis (ExRA) with high mortality. The aim of our study was to examine clinical characteristics of IOD in rheumatoid arthritis (RA) and their effect on disease severity and outcomes in recent years. METHODS: A retrospective cohort of RA patients with IOD evaluated between 1996 and 2013 was assembled and compared to RA comparators without IOD and matched for age, sex, and disease duration...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449025/-prospective-monocentric-uncontrolled-study-of-efficacy-tolerance-and-adherence-of-cyclosporin-0-1-for-severe-dry-eye-syndrome
#5
Y Boujnah, R Mouchel, H El-Chehab, C Dot, C Burillon, V Kocaba
PURPOSE: To evaluate the efficacy, tolerability and treatment adherence of Ikervis ® (Santen, SAS) (ciclosporine 0.1 %) for first line therapy or following treatment with Restasis ® (Allergan, Inc.) (ciclosporine 0.05 %) for severe dry eye syndrome. MATERIAL AND METHODS: A prospective, monocentric, uncontrolled study was conducted between January 2012 and March 2015 on 110 eyes of 55 patients with severe dry eye on first line therapy or previously treated with Restasis ® who required the introduction of Ikervis ® ...
February 12, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29448286/-mitochondrial-dysfunctions-and-role-of-coenzyme-q10-in-patients-with-glaucoma
#6
Carl Erb, Katarzyna Konieczka
Mitochondrial function is closely linked to numerous aspects of eye health. Imbalance between the creation of energy and the development of reactive oxygen species (ROS) seems to be the cause of the development of mitochondrial dysfunctions. As a result of this energy deficit, the level of oxidative stress in the eye tissues increases, leading to numerous ophthalmic impairments. It is important to distinguish between primary mitochondrial eye diseases and secondary mitochondrial changes. Primary mitochondrial eye diseases, for example Leber's hereditary optic atrophy (LHON), retinitis pigmentosa and chronic progressive external ophthalmoplegia are caused by direct damage to mitochondrial function induced by defective genes, either located on mitochondrial DNA (mtDNA) or the DNA of the nucleus (nDNA)...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29445264/exercise-program-improved-subjective-dry-eye-symptoms-for-office-workers
#7
Kokoro Sano, Motoko Kawashima, Sayuri Takechi, Masaru Mimura, Kazuo Tsubota
Introduction: We investigated the benefits of a cognitive behavior therapy-based exercise program to reduce the dry eye symptoms of office workers. Materials and methods: We recruited 11 office workers with dry eye symptoms, aged 31-64 years, who voluntarily participated in group health guidance at a manufacturing company. Participants learned about the role of physical activity and exercise in enhancing wellness and performed an exercise program at home 3 days per week for 10 weeks...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29445135/alteration-in-nerves-and-neurotransmitter-stimulation-of-lacrimal-gland-secretion-in-the-tsp-1-mouse-model-of-aqueous-deficiency-dry-eye
#8
Sumit Bhattacharya, Laura García-Posadas, Robin R Hodges, Helen P Makarenkova, Sharmila Masli, Darlene A Dartt
The purpose of this study is to determine neural, vascular, protein secretion, and cellular signaling changes with disease progression in lacrimal glands of the thrombospondin-1 -/- (TSP-1 -/- ) mouse model of dry eye compared to C57BL/6 wild-type (WT) mice. Neural innervation was reduced in TSP-1 -/- lacrimal glands compared to WT controls, whereas the number of blood vessels was increased. Intracellular Ca 2+ stores and the amount of lysosomes, mitochondria, and secretory granules, but not the endoplasmic reticulum, were reduced in TSP-1 -/- compared to WT acini at 12 weeks of age...
February 14, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29443034/subretinal-transplantation-of-human-embryonic-stem-cell-derived-retinal-pigment-epithelial-cells-into-a-large-eyed-model-of-geographic-atrophy
#9
Sandra Petrus-Reurer, Hammurabi Bartuma, Monica Aronsson, Sofie Westman, Fredrik Lanner, Anders Kvanta
Geographic atrophy (GA), the late stage of dry age-related macular degeneration is characterized by loss of the retinal pigment epithelial (RPE) layer, which leads to subsequent degeneration of vital retinal structures (e.g., photoreceptors) causing severe vision impairment. Similarly, RPE-loss and decrease in visual acuity is seen in long-term follow up of patients with advanced wet age-related macular degeneration (AMD) receiving intravitreal anti-vascular endothelial growth factor (VEGF) treatment. Therefore, on the one hand, it is fundamental to efficiently derive RPE cells from an unlimited source that could serve as replacement therapy...
January 22, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29440872/topical-ocular-0-1-cyclosporine-a-cationic-emulsion-in-dry-eye-disease-patients-with-severe-keratitis-experience-through-the-french-early-access-program
#10
Pierre-Jean Pisella, Marc Labetoulle, Serge Doan, Beatrice Cochener-Lamard, Mourad Amrane, Dahlia Ismail, Catherine Creuzot-Garcher, Christophe Baudouin
Purpose: The objective of this study was to report the evaluation of efficacy and safety of cyclosporine A cationic emulsion (CsA CE) 0.1% for the treatment of severe keratitis in adults with dry eye disease (DED) in a French early-access program. Methods: Patients with DED and severe keratitis (corneal fluorescein staining [CFS] score of 3-5 on the Oxford scale and/or the presence of corneal lesions [filaments or ulcers]) were enrolled in a compassionate use program (Authorization for Temporary Use [ATU]) for once-daily CsA CE, which was approved by French health authorities prior to its registration...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29440868/ocular-comfort-assessment-of-lifitegrast-ophthalmic-solution-5-0-in-opus-3-a-phase-iii-randomized-controlled-trial
#11
Kelly K Nichols, Edward Holland, Melissa M Toyos, James H Peace, Parag Majmudar, Aparna Raychaudhuri, Mohamed Hamdani, Monica Roy, Amir Shojaei
Purpose: To evaluate ocular comfort of lifitegrast ophthalmic solution 5.0% among patients with dry eye disease (DED) in the OPUS-3 trial. Methods: OPUS-3 was a multicenter, randomized, double-masked, placebo-controlled study. Adults with DED and recent artificial tear use were randomized 1:1 (lifitegrast:placebo) to ophthalmic drops twice daily for 84 days. On days 0 (baseline), 14, 42, and 84, drop comfort score (scale, 0-10; 0 = very comfortable, 10 = very uncomfortable) was measured at 0, 1, 2, and 3 minutes postinstillation...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29438123/relationships-between-meibomian-gland-loss-and-age-sex-and-dry-eye
#12
Heiko Pult
PURPOSE: This study evaluated relationships between meibomian gland loss (MGL) and age, sex, and dry eye. METHODS: Dry eye and MGL of the lower eyelid was evaluated from 112 randomly selected subjects (66 women; mean age 62.8; SD ±15.7; and age range: 19-89 years) from Horst Riede GmbH, Weinheim, Germany. In addition, subjects were grouped into dry eye and non-dry eye by the Ocular Surface Disease Index (OSDI) score, lid-parallel conjunctival folds and non-invasive break-up time...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29429301/-research-progress-of-corneal-langerhans-cells-role-in-the-pathogenesis-of-dry-eye-disease
#13
X Yang, Y Li
Dry eye disease (DED) is the most common ocular surface diseasenowadays. DED can be divided into different types based on the pathogenesis. The progression of DED is strongly related to chronic ocular surface inflammation, regardless of the type of DED. The corneal Langerhans cells (LC) are the dedicated antigen presenting cells in the ocular surface immune system. Along with further understanding of LC recently, its double-sided functions have been discovered: on one hand, LC phagocytize antigen and induce immune tolerance, and on the other hand, LC process and present antigen, and initiate immune response...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429300/-research-progress-of-conscious-pain-and-neurosensory-abnormalities-in-dry-eye-disease
#14
X Lin, Z L Liu, J L Wu, Z G Liu
Dry eye is one of the most common ocular problems in ophthalmology clinic. With the change of social environment and people's life style, the prevalence of dry eye disease is increasing. Currently, the diagnosis criteria for dry eye is controversial, diagnosis of dry eye mainly rely on the comprehensive assessment of symptoms and the presence of associated ocular surface signs. However, previous studies have shown a poor correlation between dry eye symptoms and objective clinical signs in patients. Recent studies have found that neuropathic pain plays an important role in the occurrence of discordance between symptoms and signs in dry eye disease...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429299/-research-progress-of-intense-pulsed-light-treatment-on-meibomian-gland-dysfunction-and-relevant-dry-eye-diseases
#15
W J Song, X M Yan
Intense pulsed light (IPL) is a broad spectrum incoherent light which is produced by high-output xenon lamp. Since the invention of the first-generation IPL in 1994, IPL technology has been developing rapidly and extensively utilized in multiple fields relevant to dermatology across the world. In 2004, the fourth-generation IPL system was introduced with the optimal pulse technology (OPT) and has soon been used for cosmetic purposes all over the world. In 2002, Dr. Toyos found that the meibomian gland dysfunction (MGD) and dye eye disease (DED)symptoms of the rosacea patients who received IPL treatment have been improving significantly, therefore he started to explore the application of IPL system to treatment of dry eye disease...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429291/-focusing-on-the-management-of-chronic-dry-eye-disease
#16
Z G Liu, H Wang
Dry eye has become the most common ophthalmic disease besides ametropia. As a chronic ophthalmic disease, dry eye, which in serious cases might even lead to blindness, not only affects the life quality of the patient, but also poses adverse impact on social productivity and work efficiency, and moreover influences the development of society and economy. The incidence of dry eye has been rising in recent years because of the widespread use of video terminals, which poses greater challenges for us. Therefore, we put forward the concept of chronic disease management for dry eye in the hope of drawing extensive attention and planning ahead of time, so as to meet the needs of dry eye patients in China...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29426737/-demodex-genus-colonizing-parasites-of-healthy-people-or-mites-associated-with-ocular-pathology
#17
Florencia Mongi, Laura Laconte, Rodolfo D Casero
Demodex folliculorum and Demodex brevis are mites that are responsible for human demodicosis affecting skin and frequently linked to ocular diseasess. The aim of this work was to determine the association between Demodex sp. and eyelid and eyelash diseases and to establish the predisposing factors for acquiring this parasitic disease. Eyelashes from symptomatic and asymptomatic patients (n=72) between 9 and 82 years old were analyzed, where 53% were positive for Demodex sp., of which 66% manifested ocular symptoms and pathologies, blepharitis and dry eye being prevalent...
February 6, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29422755/comparison-of-the-efficacy-of-carboxymethylcellulose-0-5-hydroxypropyl-guar-containing-polyethylene-glycol-400-propylene-glycol-and-hydroxypropyl-methyl-cellulose-0-3-tear-substitutes-in-improving-ocular-surface-disease-index-in-cases-of-dry-eye
#18
Prafulla K Maharana, Sapna Raghuwanshi, Ashish K Chauhan, Vaishali G Rai, Rajesh Pattebahadur
PURPOSE: To compare the efficacy of carboxymethylcellulose 0.5% (CMC), hydroxypropyl-guar containing polyethylene glycol 400/propylene glycol (PEG/PG), and hydroxypropyl methylcellulose 0.3% (HPMC) as tear substitutes in patients with dry eye. METHODS: A retrospective evaluation of cases presenting with symptoms of dry eye from July 2014 to June 2015 was done. Patients with Ocular Surface Disease Index (OSDI) scoring >12 were included in the study. Parameters such as age, gender, Schirmer test (ST), and tear film breakup time (TBUT) were recorded on day 0, week 1, and week 4...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29417445/a-rating-scale-is-a-proper-method-to-evaluate-changes-in-quality-of-life-due-to-dry-eye-symptoms
#19
Wenwen Xue, Xian Xu, Haidong Zou
PURPOSE: To determine which utility value assessment method is more suitable to evaluate changes in the quality of life due to dry eye symptoms. METHODS: Dry eye outpatients with a presenting visual acuity of 20/25 or better in the worse-seeing eye were recruited. Presenting distance visual acuity, tear film break-up time, Schirmer I test and fluorescein were assessed. The severity of dry eye symptoms was assessed using the Ocular Surface Disease Index (OSDI), and utility values were measured using the time trade-off (TTO), standard gamble (SG1 and SG2) and rating scale (RS) methods...
February 7, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29409963/web-based-longitudinal-remote-assessment-of-dry-eye-symptoms
#20
Francisco Amparo, Reza Dana
PURPOSE: To investigate the feasibility of remote assessment and follow-up of dry eye symptoms using electronic versions of two validated questionnaires. METHODS: We conducted a prospective study of consecutive patients with dry eye disease (DED). Patients were enrolled during a clinical visit and were explained how to respond electronic versions of the Ocular surface Disease Index (OSDI) and the Symptom Assessment in Dry Eye (SANDE) questionnaires using a computer in the presence of investigators...
January 31, 2018: Ocular Surface
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