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https://www.readbyqxmd.com/read/28222481/effect-of-diquafosol-three-per-cent-ophthalmic-solution-on-tear-film-and-corneal-aberrations-after-cataract-surgery
#1
Hun Lee, Sang Myung Kim, Seonghee Choi, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
BACKGROUND: The aim was to evaluate the effect of diquafosol on tear film parameters and corneal aberrations after cataract surgery. METHODS: This retrospective, comparative, observational case series included patients who underwent cataract surgery with or without peri-operative use of diquafosol three per cent ophthalmic solution. Patients in group I (31 eyes) were treated with diquafosol three per cent ophthalmic solution six times a day from one week before surgery to three months after surgery...
February 21, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28211183/a-comparison-of-the-self-reported-dry-eye-practices-of-new-zealand-optometrists-and-ophthalmologists
#2
Ally L Xue, Laura E Downie, Susan E Ormonde, Jennifer P Craig
PURPOSE: The aim of this cross-sectional survey was to evaluate the self-reported clinical practices of New Zealand optometrists and ophthalmologists with respect to the diagnosis and management of dry eye disease. It also sought to compare these behaviours with the current research evidence base. METHODS: An anonymous survey was distributed electronically to New Zealand eye care clinicians (optometrists n = 614, ophthalmologists n = 113) to determine practitioner interest in dry eye disease, practice experience, practice modality, preferred diagnostic and management strategies, and information used to guide patient care...
March 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28207920/paper-based-microfluidic-system-for-tear-electrolyte-analysis
#3
Ali K Yetisen, Nan Jiang, Ali Tamayol, Guillermo U Ruiz-Esparza, Yu Shrike Zhang, Sofía Medina-Pando, Aditi Gupta, James S Wolffsohn, Haider Butt, Ali Khademhosseini, Seok-Hyun Yun
The analysis of tear constituents at point-of-care settings has a potential for early diagnosis of ocular disorders such as dry eye disease, low-cost screening, and surveillance of at-risk subjects. However, current minimally-invasive rapid tear analysis systems for point-of-care settings have been limited to assessment of osmolarity or inflammatory markers and cannot differentiate between dry eye subclassifications. Here, we demonstrate a portable microfluidic system that allows quantitative analysis of electrolytes in the tear fluid that is suited for point-of-care settings...
February 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28197326/efficacy-of-carboxymethylcellulose-and-hyaluronate-in-dry-eye-disease-a-systematic-review-and-meta-analysis
#4
Jae Kyeong Song, Kiheon Lee, Hwa Yeon Park, Joon Young Hyon, Seung-Won Oh, Woo Kyung Bae, Jong-Soo Han, Se Young Jung, Yoo Jin Um, Ga-Hye Lee, Ji Hye Yang
BACKGROUND: The efficacy of two artificial tears, carboxymethylcellulose (CMC) and hyaluronate (HA), was compared in the treatment of patients with dry eye disease. METHODS: We conducted a systematic review and meta-analysis on randomized controlled trials in the PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases. The efficacy was compared in terms of the mean change from baseline in tear break-up time. The meta-analysis was conducted using both random and fixed effect models...
January 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28192377/application-of-casia-ss-1000-optical-coherence-tomography-tear-meniscus-imaging-in-testing-the-efficacy-of-new-strip-meniscometry-in-dry-eye-diagnosis
#5
Megumi Shinzawa, Murat Dogru, Keiichi Miyasaka, Jun Shimazaki, Tetsuju Sekiryu
PURPOSE: To investigate the applicability of CASIA SS-1000 anterior-segment optical coherence tomography (AS-OCT) imaging parameters in testing the efficacy of the new strip meniscometry (SM) namely "Strip Meniscometry Tube" (SMTube) in the diagnosis of dry eyes. METHODS: Forty-three eyes of 22 patients (4 men and 18 women) with definite dry eye disease (DED) and 49 eyes of 28 normal controls (6 men and 22 women) were studied. All subjects underwent symptom questionnaires, SMTube, the Schirmer-1 test, tear film break-up time measurement, vital staining examinations, as well as tear meniscus height (TMH) and TM area (TMA) measurements using an AS-OCT system...
January 6, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28181960/barriers-to-glaucoma-medication-compliance-among-veterans-dry-eye-symptoms-and-anxiety-disorders
#6
Jack Stringham, Noy Ashkenazy, Anat Galor, Sarah R Wellik
OBJECTIVE: To identify barriers to compliance of medical treatment for glaucoma among veterans. METHODS: Patients with glaucoma from the Miami Veterans Affairs Eye Clinic (n=74) filled out a 63-question survey regarding dry eye symptoms, concurrent systemic disease, and medications. The association between glaucoma medical compliance was defined as self-reported adherence to drop regimens greater than 75% of the time. RESULTS: Eighty percent of veterans (n=59) reported compliance with glaucoma therapy...
January 6, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28181147/a-clinic-based-survey-of-clinical-characteristics-and-practice-pattern-of-dry-eye-in-japan
#7
Motoko Kawashima, Masakazu Yamada, Kazuhisa Suwaki, Chika Shigeyasu, Miki Uchino, Yoshimune Hiratsuka, Norihiko Yokoi, Kazuo Tsubota
INTRODUCTION: The aim of this study was to investigate the clinical characteristics and practice pattern of patients with dry eye disease (DED) in eye clinics across Japan. METHODS: A multi-center, cross-sectional study was conducted among patients with DED who visited eye clinics in Japan. Subjective symptoms, patient's background, ocular surface features, and tear function were evaluated. Main outcome measures were tear break-up time (TBUT), Schirmer I value, kerato-conjunctival staining score, and dry eye symptom questionnaire score...
February 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28179131/rasch-analysis-of-three-dry-eye-questionnaires-and-correlates-with-objective-clinical-tests
#8
Colm McAlinden, Rongrong Gao, Qinmei Wang, Senmiao Zhu, Jing Yang, Ayong Yu, Anthony J Bron, Jinhai Huang
PURPOSE: To assess the psychometric properties of Chinese versions of the Ocular Comfort Index (OCI), Ocular Surface Disease Index (OSDI) and McMonnies questionnaires. Further, to assess the correlation between questionnaire scores and objective dry eye disease (DED) clinical tests. METHODS: Translated versions of the OCI, OSDI and McMonnies questionnaires were completed in a random order by 238 participants with DED. Objective clinical tests included visual acuity (VA), fluorescein tear film break-up time (TBUT), corneal fluorescein staining, Schirmer I testing and meibomian gland grading...
February 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28170196/lacrimal-gland-repair-using-progenitor-cells
#9
Anastasia Gromova, Dmitry A Voronov, Miya Yoshida, Suharika Thotakura, Robyn Meech, Darlene A Dartt, Helen P Makarenkova
In humans, the lacrimal gland (LG) is the primary contributor to the aqueous layer of the tear film. Production of tears in insufficient quantity or of inadequate quality may lead to aqueous-deficiency dry eye (ADDE). Currently there is no cure for ADDE. The development of strategies to reliably isolate LG stem/progenitor cells from the LG tissue brings great promise for the design of cell replacement therapies for patients with ADDE. We analyzed the therapeutic potential of epithelial progenitor cells (EPCPs) isolated from adult wild-type mouse LGs by transplanting them into the LGs of TSP -1(-/-) mice, which represent a novel mouse model for ADDE...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28165063/heavy-chain-hyaluronan-pentraxin-3-from-amniotic-membrane-suppresses-inflammation-and-scarring-in-murine-lacrimal-gland-and-conjunctiva-of-chronic-graft-versus-host-disease
#10
Yoko Ogawa, Hua He, Shin Mukai, Toshihiro Imada, Shigeru Nakamura, Chen-Wei Su, Megha Mahabole, Scheffer C G Tseng, Kazuo Tsubota
Chronic graft-versus-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. Dry eye disease is the prominent ocular sequel of cGVHD and is caused by excessive inflammation and fibrosis in the lacrimal glands. Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purified from human amniotic membrane (AM) and known to exert anti-inflammatory and anti-scarring actions. In this study, we utilized a mouse model of cGVHD to examine whether HC-HA/PTX3 could attenuate dry eye disease elicited by cGVHD...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163544/lifitegrast-a-novel-drug-for-treatment-of-dry-eye-disease
#11
Afroz Abidi, Pooja Shukla, Ali Ahmad
Dry eye disease (DED) is an inflammatory disorder of ocular surfaces leading to severe disability, especially in the elderly age group. The mainstay of therapy includes artificial tears, punctual plugs, topical anti-inflammatory agents, and corticosteroids. In the past few years, only cyclosporine-A emulsions have been added to the existing therapy, but it is discontinued by most patients as it causes burning sensation in the eye. Hence, progress in new research for a better therapeutic option led to the discovery of lymphocyte function-associated antigen intercellular adhesion molecule 1 antagonist, lifitegrast...
October 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28162126/identification-of-objective-morphometric-markers-of-xerostomia-in-the-oral-mucosa-epithelium-with-in-vivo-confocal-microscopy
#12
Ida G Fostad, Jon R Eidet, Neil S Lagali, Darlene A Dartt, Sten Ræder, Edvard B Messelt, Tor P Utheim
The purpose of this work was to determine whether the morphology of the oral mucosa epithelium (OME) of patients with xerostomia differ from patients without xerostomia. In total, 34 patients with dry eye disease (DED) with or without xerostomia were examined at The Norwegian Dry Eye Disease Clinic with in vivo confocal microscopy of the lower lip. In addition, age- and gender-matched healthy controls (HC) were included. DED patients with xerostomia had a higher superficial to deep backscatter ratio compared with DED patients without xerostomia (p=0...
February 6, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28157225/corneal-confocal-scanning-laser-microscopy-in-patients-with-dry-eye-disease-treated-with-topical-cyclosporine
#13
B Iaccheri, G Torroni, C Cagini, T Fiore, A Cerquaglia, M Lupidi, S Cillino, H S Dua
PurposeTo investigate the effect of cyclosporine on corneal ultrastructure and on major signs and symptoms of patients with dry eye disease.Patients and methodsIn this prospective cohort study, patients with dry eye disease were treated with a drop of cyclosporine 0.05% twice daily. Clinical evaluation was carried out at baseline and at months 1, 3, and 6. All patients completed the Ocular Surface Disease Index (OSDI) questionnaire, and tear film break-up time (BUT), fluorescein and lissamine green staining, and Schirmer test were carried out...
February 3, 2017: Eye
https://www.readbyqxmd.com/read/28147407/-significance-of-new-methods-of-examining-the-tear-film-in-dry-eye-disease-tear-film-osmolarity-and-matrix-metalloproteinases-mmp-9
#14
M Schargus, G Geerling, S C Joachim
Dry eye disease is one of the most common diagnoses in ophthalmology. A variety of subjective and objective test methods with imprecise limits and highly different sensitivities and specificities complicate the diagnosis. Especially mild to moderate pathological findings can be misdiagnosed. In recent years, new options have opened, through the development of new, clinical practicable diagnostic equipment, for example, for the analysis of tear film osmolarity or matrix metalloproteinases (MMP-9). The value of tear film osmolarity and determination of MMP-9 levels in the diagnosis of dry eye and its subtypes will be discussed and evaluated objectively, on the basis of published study results...
February 1, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28146363/keratitis-in-dry-eye-disease-and-topical-ciclosporin-a
#15
Andrea Leonardi, Bruno Flamion, Christophe Baudouin
Tear film alterations in dry eye disease (DED) include reduced tear volume and an increase in inflammatory cytokines. Instability and reduced tear production initiate a vicious cycle where hyperosmolarity, ocular inflammation, and apoptosis may induce damage of the ocular surface including keratitis. Topical cyclosporine (CsA) has been used for the treatment of moderate-to-severe DED; however, previous studies failed to demonstrate its benefits by the European Agency standards. A new formulation of CsA 0.1% has been recently approved in the EU to treat severe keratitis in DED patients...
February 1, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28139245/a-metabolome-wide-study-of-dry-eye-disease-reveals-serum-androgens-as%C3%A2-biomarkers
#16
Jelle Vehof, Pirro G Hysi, Christopher J Hammond
PURPOSE: To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. DESIGN: Cross-sectional association study. PARTICIPANTS: A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17-82 years). METHODS: We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc...
January 28, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28139163/comparison-of-autologous-serum-versus-preservative-free-artificial-tear-in-patients-with-dry-eyes-due-to-systemic-isotretinoin-therapy
#17
Uğur Yılmaz, Erkut Küçük, Çağdaş Koç, Enes Gökler
PURPOSE: To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease. METHOD: This prospective, crossover, double blind study was conducted on patients who have dry eyes due to systemic isotretinoin treatment for different indications. Patients detected as having dry eye during systemic isotretinoin treatment were included to our study...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28137903/subcorneal-pustular-dermatosis-and-episcleritis-associated-with-poorly-controlled-ulcerative-colitis
#18
Jeffrey J Wargo, Megan Adams, Julian Trevino
A man aged 56 years with a history of ulcerative colitis (UC) status postsubtotal colectomy was hospitalised with fevers, dry cough, eye redness and a new bloody, mucoid rectal discharge. 2 months prior to admission, the dermatologist had started him on dapsone for subcorneal pustular dermatosis but did not recognise that he had recently self-discontinued mesalamine enemas, inducing a flare of his UC. After a thorough inpatient evaluation, including flexible sigmoidoscopy, active UC involving the rectal stump was determined to be driving his dermatological and ophthalmological findings...
January 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28134037/destiny-rides-again-the-reappearance-of-silicone-gel-filled-breast-implant-toxicity
#19
A E Brawer
Background Twenty-five years ago attorneys representing ailing women in class action litigation against silicone breast implant manufacturers made the procedural error of defining silicone-induced toxicity in the courtroom before it was properly studied in the exam room. This aberrant methodology perverted the proper research process, rendered verification of any real disease elusive, and cemented the groundwork for a repeat public health crisis potentially affecting two million women in the USA who possess new silicone gel devices inserted over the past 10 years...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28132878/emerging-strategies-for-the-diagnosis-and-treatment-of-meibomian-gland-dysfunction-proceedings-of-the-ocean-group-meeting
#20
Gerd Geerling, Christophe Baudouin, Pasquale Aragona, Maurizio Rolando, Kostas G Boboridis, José M Benítez-Del-Castillo, Yonca A Akova, Jesús Merayo-Lloves, Marc Labetoulle, Martin Steinhoff, Elisabeth M Messmer
Meibomian gland dysfunction (MGD) is a common and chronic disorder that has a significant adverse impact on patients' quality of life. It is a leading cause of evaporative dry eye disease (DED), as meibomian glands play an important role in providing lipids to the tear film, which helps to retard the evaporation of tears from the ocular surface. MGD is also often present in conjunction with primary aqueous-deficient DED. Obstructive MGD, the most commonly observed type of MGD, is the main ocus of this article...
January 26, 2017: Ocular Surface
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