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Dry eye disease

Hande Taylan Sekeroglu, Mehmet Ali Sekeroglu
Major depression is one of the most common psychiatric disorders in the developed countries, and it is well known that depressive symptoms are more frequently encountered in patients with physical disorders, especially those who have chronic diseases. Although there are numerous study concerning the relationship between ocular inflammatory diseases and depression, the majority of them mainly focus on two diseases: uveitis and dry eye disease (DED). With this review, we aimed to analyze the relation between depression and ocular inflammation, specifically DED and uveitis, in the light of the current literature and to summarize the potential mechanisms regarding this interrelation...
June 12, 2018: Current Topics in Medicinal Chemistry
X Yang, Y Li
Objective: To evaluate the short-term efficacy and psycological influence of elastic silicon punctal plugs on severe dry eye patients. Methods: Prospective case series study. Twenty-eight severe dry eye patients (56 eyes) treated with elastic silicon punctal plugs (Snug Plugs(TM), FCI Ophthalmics, France) during January to September 2017 at the ophthalmology department of Peking Union Medical College Hospital were included. All the examination results were collected at baseline and 3 months after insertion...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Z G Liu, W Li
Dry eye has become the most common ocular surface disease in China's clinical ophthalmology. However, dry eye in children has not achieved enough attention. It lacks related information of basic data and diagnostic criteria, and there is no standard for the clinical diagnosis and treatment. As dry eye in children has its own characteristics, its diagnosis and treatment are not exactly the same as adults. In recent years, due to the popularization and widespread usage of electronic products, coupled with some systemic factors, the incidence of dry eye in children has risen rapidly...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Ronald Mauricio Sanchez-Avila, Jesus Merayo-Lloves, Maria Laura Fernandez, Luis Alberto Rodriguez-Gutierrez, Nancy Jurado, Francisco Muruzabal, Gorka Orive, Eduardo Anitua
PURPOSE: The aim of this study was to evaluate the use of plasma rich in growth factors (PRGF) eye drops in patients with dry eye disease after laser-assisted in situ keratomileusis (LASIK) surgery. MATERIAL AND METHODS: This is a longitudinal, retrospective, comparative, and descriptive study of 77 eyes of 42 patients with dry eye disease following LASIK surgery. This study was designed to evaluate the efficacy of PRGF treatment compared to conventional therapy (control group)...
June 8, 2018: Ophthalmic Research
Penny A Asbell, Maureen G Maguire, Ellen Peskin, Vatinee Y Bunya, Eric J Kuklinski
PURPOSE: Describe trial design and baseline characteristics of participants in the DRy Eye Assessment and Management (DREAM©) Study. DESIGN: Prospective, multi-center, randomized, double-masked "real-world" clinical trial assessing efficacy and safety of oral omega-3 (ω3) supplementation for the treatment of dry eye disease (DED). METHODS: RESULTS: Mean age of participants was 58.0 ± 13.2 years. Mean OSDI score at baseline was 44...
June 5, 2018: Contemporary Clinical Trials
Michael T M Wang, Leslie Tien, Alicia Han, Jung Min Lee, Dabin Kim, Maria Markoulli, Jennifer P Craig
PURPOSE: To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology. METHODS: A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session. RESULTS: Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0...
June 5, 2018: Ocular Surface
Miki Uchino, Motoko Kawashima, Yuichi Uchino, Natume Suzuki, Hiroto Mitamura, Miki Mizuno, Yuichi Hori, Norihiko Yokoi, Kazuo Tsubota
PURPOSE: To evaluate the usefulness of a dry eye mobile application (app) for screening dry eye disease (DED) at educational tear events in Japan. METHODS: In this cross-sectional study, Japanese subjects visiting a "Tears Day" event were selected randomly. They completed questionnaires and underwent ophthalmic evaluations for DED (using Japanese revised diagnostic criteria) including a functional visual acuity (FVA) test. The app calculated FVA using the average of the continuous VA over 30 s...
June 5, 2018: Ocular Surface
Gemma Caterina Maria Rossi, Luigia Scudeller, Federica Bettio, Gian Maria Pasinetti, Paolo Emilio Bianchi
PURPOSE: To estimate the prevalence of dry eye among video-terminal (VDT) users and to assess risk factors for dry eye in this population. STUDY DESIGN: A single-centre, cross-sectional study was carried out on subjects employed as VDT workers and on a control group. METHODS: Demographic data, years spent working at a VDT, number of effective hours at VDT/day, number and hours of breaks/day were considered. All subjects underwent a complete ophthalmic examination and completed the Italian version of the computer vision symptom scale 17-item (CVSS17) questionnaire...
June 7, 2018: International Ophthalmology
Lapam Panda, Umasankar Barik, Suryasmita Nayak, Biswajit Barik, Gyanaranjan Behera, Ramesh Kekunnaya, Taraprasad Das
Purpose: To evaluate effectiveness of Welch Allyn Spot Vision Screener in detecting refractive error in all age groups and amblyopia risk factors in children in a tribal district of India. Methods: All participants received dry retinoscopy and photorefraction; children also received cycloplegic retinoscopy. Statistical analysis included Bland-Altman and coefficient of determination ( R 2 ). Results: Photoscreener could not elicit a response in 113 adults and 5 children of 580 recruited participants...
May 2018: Translational Vision Science & Technology
Laura L Hanson, Zubair Ahmed, Bradley J Katz, Judith E A Warner, Alison V Crum, Yingying Zhang, Yue Zhang, Susan Baggaley, Karly Pippett, Melissa M Cortez, Kathleen B Digre
OBJECTIVE: Migraine is associated with several important visual symptoms, during both acute attacks and headache-free intervals. The purpose of this investigation was to use validated vision-related quality of life instruments to assess the effect of migraine on visual quality of life. BACKGROUND: Many migraineurs experience visual aura, increased photophobia during and between headache attacks, and increased symptoms of dry eye with structural changes in corneal nerve endings...
June 7, 2018: Headache
Boglarka Racz, Andras Varadi, Jian Kong, Rando Allikmets, Paul G Pearson, Graham Johnson, Christopher L Cioffi, Konstantin Petrukhin
A primary pathological defect in the heritable eye disorder Stargardt disease is excessive accumulation of cytotoxic lipofuscin bisretinoids in the retina. Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) matches the age-dependent increase in the incidence of the atrophic (dry) form of age-related macular degeneration (AMD) and therefore may be one of several pathogenic factors contributing to AMD progression. Lipofuscin bisretinoid synthesis in the retina depends on the influx of serum retinol from the circulation into the RPE...
June 5, 2018: Journal of Biological Chemistry
Michael-Adrien Vitoux, Karima Kessal, Christophe Baudouin, Stéphane Melik Parsadaniantz, Sophie Achard, Françoise Brignole-Baudouin
Dry eye (DE) is a multifactorial ocular surface disease whose incidence continues to rise. Various environmental stresses such as low air humidity and pollution are known to be involved in epithelial alterations inducing ocular discomfort. However, no experimental study assessing the combined effects of dry air and polluted atmospheres has been conducted so far. Formaldehyde (FA) is a ubiquitous pollutant present in the living spaces where humans spend most of their time. Using an in vitro DE model, we evaluated the cytotoxic and inflammatory responses of a conjunctival cell line exposed at the air-liquid interface (ALI) conditions to various controlled atmospheres combining low humidity (LH), airflow (AF) and formaldehyde gas (FG)...
May 31, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Xue Zhang, Zhishun Liu, Wentao Ding, Jun Zhang, Huan Shi, Wenzeng Zhu
BACKGROUND: Dry eye disease (DED) is a very common disease. Although several current treatments offer some symptomatic relief, moderate to severe DED is still difficult to cure at present. Acupuncture may be effective for DED via its promotion of tear secretion and ability to improve symptoms, but evidence of its effectiveness is limited. The aim of this study is to evaluate the effect of acupuncture versus artificial tears in moderate to severe DED. METHODS/DESIGN: A total of 120 participants with moderate to severe DED will be randomly assigned to either an acupuncture group or an artificial tear group at a ratio of 1:1...
June 2018: Medicine (Baltimore)
Wen-Long Hu, Pei-Chang Wu, Li-Yen Pan, Hun-Ju Yu, Chih-Chin Pan, Yu-Chiang Hung
BACKGROUND: Dry eye is a common ophthalmologic disorder that causes ocular discomfort and has become a worldwide health concern. Patients with dry eye often turn to complementary and alternative medicine (CAM) because of unsatisfactory conventional treatments. Acupuncture is one of the most popular interventions of CAM used, and laser acupuncture (LA) is a noninvasive technique. METHODS: This protocol is a 2-center randomized controlled trial investigating the effect of laser acupuncture on dry eye...
June 2018: Medicine (Baltimore)
Konstadinos G Boboridis, Anastasios G P Konstas
Ocular surface disease (OSD) is a highly prevalent symptomatic condition caused by dry eye disease (DED), intrinsic, environmental, or iatrogenic causes. It affects patient's visual function and quality of life. Its pathophysiology is centered on tear hyperosmolarity, inflammation, and epithelial damage. Current management is suboptimal and includes artificial tear supplementation and short-term use of topical steroids in severe cases. The recent approval of cyclosporine 0.1% has transformed management strategies of severe DED and moderate-to-severe OSD...
May 30, 2018: Expert Opinion on Pharmacotherapy
Mohamed Nagy Elmohamady, Walid Abdelghaffar, Ahmed Daifalla, Tamer Salem
Purpose: To evaluate femtosecond laser in flap and cap creation, detect some corneal biomechanical changes, and evaluate dry eye after laser in situ keratomileusis (LASIK), Femto-LASIK, and small incision lenticule extraction (SMILE) with 3-year follow-up. Patients and methods: Preoperative evaluation taken: full ophthalmic examination, Pentacam, ocular response analyzer, ocular surface disease index (OSDI), and tear breakup time (TBUT). LASIK flap was created using Moria microkeratome in 30 eyes (LASIK group) and using VisuMax femtosecond laser in 38 eyes (FS-LASIK group) and SMILE was done by VisuMax in 35 eyes (SMILE group)...
2018: Clinical Ophthalmology
Tina T Wong, Tin Aung, Ching Lin Ho
IMPORTANCE: Glaucoma treatment has often been associated with adverse side-effects from preservatives that are included in the used eye drops. BACKGROUND: To evaluate changes in the ocular surface and the presence of prostaglandin-induced corneal disorders after being switched from latanoprost 0.005% to low preservative tafluprost 0.0015% ophthalmic solution. DESIGN: Single centre, prospective study. PARTICIPANTS: Patients with primary open-angle glaucoma or ocular hypertension that had received treatment with once daily latanoprost 0...
May 26, 2018: Clinical & Experimental Ophthalmology
Erlend C S Landsend, Øygunn A Utheim, Hilde R Pedersen, Hans Christian D Aass, Neil Lagali, Darlene A Dartt, Rigmor C Baraas, Tor P Utheim
Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid was collected with Schirmer I test and capillary tubes from each eye, and the concentration of 27 inflammatory cytokines determined using multiplex bead assay. Eyes of all participants were examined with tests for dry eye disease, including evaluation of meibomian glands (meibography)...
April 1, 2018: Investigative Ophthalmology & Visual Science
Sergio Claudio Saccà, Carlo Alberto Cutolo, Daniele Ferrari, Paolo Corazza, Carlo Enrico Traverso
Polyunsaturated fatty acids (PUFA) are known to have numerous beneficial effects, owing to their anti-inflammatory and antioxidant properties. From a metabolic standpoint, the mitochondria play a fundamental role in cellular homeostasis, and oxidative stress can affect their functioning. Indeed, the mitochondria are the main source of ROS, and an imbalance between ROS and antioxidant defenses leads to oxidative stress. In addition, aging, the decline of cellular functions, and continual exposure to light underlie many diseases, particularly those of the eye...
May 24, 2018: Nutrients
Brendon W H Lee, Jeremy C K Tan, Melissa Radjenovic, Minas T Coroneo, Dedee F Murrell
BACKGROUND: Epidermolysis bullosa (EB) and autoimmune blistering diseases (AIBD) describe a group of rare chronic dermatoses characterized by cutaneous fragility and blistering. Although uncommon, significant ocular surface disease (OSD) may occur in both and require ophthalmological assessment. Disease scoring systems have a critical role in providing objective and accurate assessment of disease severity. The objectives of this report were, firstly, to document the prevalence and severity of ocular involvement in EB/AIBD...
May 22, 2018: Orphanet Journal of Rare Diseases
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