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Dry eye disease

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https://www.readbyqxmd.com/read/29042648/proteomic-analysis-of-human-lacrimal-and-tear-fluid-in-dry-eye-disease
#1
Jae Hun Jung, Yong Woo Ji, Ho Sik Hwang, Jae Won Oh, Hyun Chang Kim, Hyung Keun Lee, Kwang Pyo Kim
To understand the pathophysiology of dry eye disease (DED), it is necessary to characterize proteins in the ocular surface fluids, including tear fluid (TF) and lacrimal fluid (LF). There have been several reports of TF proteomes, but few proteomic studies have examined LF secreted from the lacrimal gland (LG). Therefore, we characterized the proteins constituting TF and LF by liquid chromatography mass spectrometry. TF and LF were collected from patients with non-Sjögren syndrome DED and from healthy subjects...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29039509/evaluation-of-a-novel-dry-eye-model-induced-by-oral-administration-of-finasteride
#2
Kai Li, Chuanwei Zhang, Zichao Yang, Yuliang Wang, Haipeng Si
Dry eye is a common eye disease, and suitable animal models are indispensable for investigating the pathogenesis and developing treatments for dry eye. The present study was conducted to develop an androgen deficiency dry eye model induced by finasteride, and to evaluate ocular surface status and inflammatory cytokine gene expression in the lacrimal gland using a cytokine antibody array system. The results revealed that the antiandrogenic drug finasteride induced significant tear deficiency, and the histopathology results revealed significant inflammatory cell infiltration in the lacrimal gland...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29034584/modern-therapeutic-approaches-for-noninfectious-ocular-diseases-involving-inflammation
#3
REVIEW
Michelle L Ratay, Elena Bellotti, Riccardo Gottardi, Steven R Little
Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29033539/possible-association-between-subtypes-of-dry-eye-disease-and-seasonal-variation
#4
Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi
PURPOSE: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). METHODS: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29031646/international-publication-trends-in-dry-eye-disease-research-a-bibliometric-analysis
#5
Christophe Boudry, C Baudouin, Fréderic Mouriaux
PURPOSE: To perform a bibliometric analysis in the field of dry eye disease (DED) research to characterize the current international status of DED research and to identify the most effective actors (journals, countries, authors) involved in this field. METHODS: Scientometric methods were used to evaluate global scientific production and development trends in DED research using the Web of Science Core Collection. RESULTS: The growth of the literature related to DED averaged 12...
October 11, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29031645/neuropathic-pain-and-dry-eye
#6
REVIEW
Anat Galor, Hamid-Reza Moein, Charity Lee, Adriana Rodriguez, Elizabeth R Felix, Konstantinos D Sarantopoulos, Roy C Levitt
Dry eye is a common, multifactorial disease currently diagnosed by a combination of symptoms and signs. Its epidemiology and clinical presentation have many similarities with neuropathic pain outside the eye. This review highlights the similarities between dry eye and neuropathic pain, focusing on clinical features, somatosensory function, and underlying pathophysiology. Implications of these similarities on the diagnosis and treatment of dry eye are discussed.
October 11, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29023310/lid-parallel-conjunctival-folds-and-their-ability-to-predict-dry-eye
#7
Heiko Pult, Stefan Bandlitz
PURPOSE: The observation of lid-parallel conjunctival folds (LIPCOF) is reported to be useful in dry eye diagnoses. Around 70% of the European clinicians use this test in a dry eye clinic. This study investigated the sensitivity and specificity of LIPCOF to predict dry eye. METHODS: Ocular Surface Disease Index (OSDI) outcome, noninvasive break-up time (NIKBUT) using the Keratograph (Oculus, Wetzlar, Germany), and LIPCOF of 148 randomized selected patient reports (88 females; mean age=37...
October 11, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29023237/corneal-tissue-from-dry-eye-donors-leads-to-enhanced-graft-rejection
#8
Takenori Inomata, Jing Hua, Takeshi Nakao, Tina Shiang, Homer Chiang, Afsaneh Amouzegar, Reza Dana
PURPOSE: To assess the effect of dry eye disease (DED) in graft donors on dendritic cell (DC) maturation, host T-cell sensitization, and corneal allograft rejection. METHODS: Corneas of control (healthy donor) and DED mice (C57BL/6) were transplanted onto fully allogeneic naive BALB/c recipients (n = 10 mice/group). Long-term allograft survival was evaluated for 8 weeks. Corneas and draining lymph nodes (dLNs) were harvested at posttransplantation day 14 (n = 5 mice/group)...
October 10, 2017: Cornea
https://www.readbyqxmd.com/read/29023165/clinical-characteristics-of-ocular-sarcoidosis-a-population-based-study-1976-2013
#9
Patompong Ungprasert, Andrea A Tooley, Cynthia S Crowson, Eric L Matteson, Wendy M Smith
PURPOSE: To characterize the epidemiology and clinical characteristics of ocular involvement in patients with systemic sarcoidosis. METHODS: An inception cohort of patients with systemic sarcoidosis in 1976-2013 in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Medical records of those patients were then reviewed for ocular involvement. RESULTS: A total of 345 incident cases of systemic sarcoidosis were identified...
October 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29022952/ocular-morbidity-among-porters-at-high-altitudes
#10
Subodh Gnyawali, Gauri Shankar Shrestha, Safal Khanal, Talisa Dennis, John C Spencer
INTRODUCTION: High altitude, often characterized by settings over 2400m, can be detrimental to the human body and pose a significant risk to ocular health. Reports concerning various ocular morbidities occurring as a consequence of high altitude are limited in the current literature. OBJECTIVES: This study was aimed at evaluating the ocular health of porters working at high altitudesof Himalayas in Nepal. MATERIALS AND METHODS: A mobile eye clinic was set up in Ghat and patient data were collected from its out- patient unit by a team of seven optometrists which was run for five days...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29018565/health-related-quality-of-life-and-depression-among-participants-in-the-sj%C3%A3-gren-s-international-collaborative-clinical-alliance-registry
#11
Annie Chou, John A Gonzales, Troy E Daniels, Lindsey A Criswell, Stephen C Shiboski, Caroline H Shiboski
OBJECTIVE: To examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren's syndrome (SS) registry, comparing those with and without SS. METHODS: Cross-sectional study of participants in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. The 2016 American College of Rheumatology/European League Against Rheumatism SS classification criteria were used to determine disease status. HRQoL was assessed using the Short Form 12, version 2 Health Survey to derive scores for physical component summary (PCS) and mental component summary (MCS)...
2017: RMD Open
https://www.readbyqxmd.com/read/28993732/purinergic-signalling-therapeutic-developments
#12
REVIEW
Geoffrey Burnstock
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990's when receptor subtypes for purines and pyrimidines were cloned and characterised, which includes four subtypes of the P1 (adenosine) receptor, seven subtypes of P2X ion channel receptors and 8 subtypes of the P2Y G protein-coupled receptor. Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28985814/tear-osmolarity-and-subjective-dry-eye-symptoms-in-migraine-sufferers
#13
Melody Wong, Mary-Magdalene Dodd, Paul Masiowski, Vikas Sharma
OBJECTIVE: Previous studies have suggested an association between dry eye and migraine. In a busy ophthalmologist clinic, quick identification of dry eye in migraine sufferers may improve their quality of life. Tear osmolarity is an objective and reliable tool for diagnosing dry eye. It has not been investigated in any population with migraine. Using tear osmolarity and questionnaires, we aimed to explore the relationship between dry eye and clinical symptoms in patients with migraine...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28982950/advances-in-dry-eye-imaging-the-present-and-beyond
#14
REVIEW
Tommy C Y Chan, Kelvin H Wan, Kendrick C Shih, Vishal Jhanji
New advances in imaging allow objective measurements for dry eye as well as define new parameters that cannot be measured by clinical assessment alone. A combination of these modalities provides unprecedented information on the static and dynamic properties of the structural and functional parameters in this multifactorial disease. A literature search was conducted to include studies investigating the use of imaging techniques in dry eye disease. This review describes the application of non-invasive tear breakup time, optical coherence tomography, meibomian gland imaging, interferometry, in vivo confocal microscopy, thermography and optical quality assessment for this condition...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28975090/chronic-dietary-oxalate-nephropathy-after-intensive-dietary-weight-loss-regimen
#15
Gebran Khneizer, Ahmad Al-Taee, Meher S Mallick, Bahar Bastani
BACKGROUND: Hyperoxaluria has been associated with nephrolithiasis as well as acute and chronic kidney disease. We present a case of end stage renal failure caused by excessive dietary oxalate intake in a dietary weight loss regimen. CASE PRESENTATION: A 51-year-old Caucasian male with the past medical history of type 2 diabetes mellitus, gout, hypertension and morbid obesity was referred to the primary care clinic after being found pale and easily fatigued. The patient had lost 36 kg over a 7-month period by implementing exercise and intense dietary measures that included 6 meals of spinach, kale, berries, and nuts...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28974417/pregnancy-probabilistically-augments-potential-precursors-to-chronic-immune-mediated-or-autoimmune-lacrimal-gland-infiltrates
#16
Austin K Mircheff, Yanru Wang, Meng Li, Billy X Pan, Chuanqing Ding
PURPOSE: This study asked whether pregnancy, a risk factor for dry eye disease associated with both chronic, immune-mediated- and autoimmune etiologies, augments development of clusters of coordinately functioning cells (CCFC) that may be precursors to pathological lacrimal gland infiltrates. METHODS: Lacrimal glands were from six virgin- and six term-pregnant rabbits of the same age and environmental exposure history. Seventy-two immune response-related gene transcripts were assayed by real time RT-PCR...
September 30, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28972684/the-effects-of-topical-aqueous-sirolimus-on-tear-production-in-normal-dogs-and-dogs-with-refractory-dry-eye
#17
Ronald Spatola, Brad Nadelstein, Andrew Berdoulay, Robert V English
PURPOSE: To evaluate the effect of twice daily aqueous 0.02% sirolimus drops on tear production in normal dogs and dogs with refractory keratoconjunctivitis sicca (KCS). METHODS: Two groups of dogs were studied. Ten normal dogs with no signs of ocular disease were administered topical 0.02% sirolimus ophthalmic solution in right eye, and a vehicle control in the left eye twice daily for 4 weeks. Complete ophthalmic examinations, including Schirmer tear test were performed weekly...
October 3, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28969614/public-awareness-of-common-eye-diseases-in-jordan
#18
Mera F Haddad, May M Bakkar, Nour Abdo
BACKGROUND: Cataract, glaucoma, diabetic retinopathy and dry eye disease are common with high prevalence in Jordan. This study aims to assess the awareness of these ocular diseases among Jordanian population. METHOD: A self-designed questionnaire was developed in Arabic and used to interview people in different provinces of Jordan. Socio-demographic data e.g. age, gender and level of education was reported. Public awareness of four ocular diseases; cataract, glaucoma, diabetic retinopathy (DR) and dry eye disease (DED) was assessed...
October 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28967083/author-s-reply-to-concerns-over-efficacy-and-safety-of-0-1-cyclosporine-a-cationic-emulsion-in-the-treatment-of-severe-dry-eye-disease
#19
Andrea Leonardi, Gysbert Van Setten, Mourad Amrane, Dahlia Ismail, Jean-Sebastien Garrigue, Francisco C Figueiredo, Christophe Baudouin
No abstract text is available yet for this article.
September 28, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28967079/concerns-over-efficacy-and-safety-of-0-1-cyclosporine-a-cationic-emulsion-in-the-treatment-of-severe-dry-eye-disease
#20
Louis Clearkin
No abstract text is available yet for this article.
September 28, 2017: European Journal of Ophthalmology
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