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https://www.readbyqxmd.com/read/29150896/stereospecific-control-of-peptide-gas-phase-ion-chemistry-with-cis-and-trans-cyclo-ornithine-residues
#1
Aleš Marek, Huong T H Nguyen, Břetislav Brož, František Tureček
We report non-chiral amino acid residues cis- and trans-1,4-diaminocyclohexane-1-carboxylic acid (cyclo-ornithine, cO) that exhibit unprecedented stereospecific control of backbone dissociations of singly charged peptide cations and hydrogen-rich cation radicals produced by electron-transfer dissociation (ETD). Upon collision-induced dissociation (CID) in the slow heating regime, peptide cations containing trans-cO residues undergo facile backbone cleavages of amide bonds C-terminal to trans-cO. In contrast, peptides with cis-cO residues undergo dissociations at several amide bonds along the peptide ion backbone...
November 18, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29150699/three-new-species-of-gyrodactylus-von-nordmann-1832-described-from-goodea-atripinnis-pisces-goodeidae-an-endemic-freshwater-fish-from-the-central-highlands-of-mexico
#2
Adriana García-Vásquez, Ismael Guzmán-Valdivieso, Ulises Razo-Mendivil, Miguel Rubio-Godoy
Goodea atripinnis Jordan, 1880 has a broad range of habitats and is the most widespread species of the endemic goodeid fishes, which inhabit the central highlands of Mexico. This species is known to be host to a high diversity of helminth parasites from which only three belong to the genus Gyrodactylus von Nordmann, 1832: G. lamothei Mendoza-Palmero, Sereno-Uribe et Salgado-Maldonado, 2009, G. mexicanus Mendoza-Palmero, Sereno-Uribe et Salgado-Maldonado, 2009, and G. tomahuac Rubio-Godoy, Razo-Mendivil, García-Vásquez, Freeman, Shinn et Paladini, 2016...
November 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29150613/a-study-of-the-ground-attachment-process-in-natural-lightning-with-emphasis-on-its-breakthrough-phase
#3
M D Tran, V A Rakov
Synchronized high-speed (124 or 210 kiloframes per second) video images and wideband electromagnetic field records of the attachment process were obtained for 4 negative strokes in natural lightning at the Lightning Observatory in Gainesville, Florida. The majority of imaged upward connecting leaders (UCLs) and upward unconnected leaders, inferred to be mostly initiated from trees, exhibited a pulsating behavior (brightening/fading cycles). UCLs, whose maximum extent ranged from 11 to 25 m, propagated in virgin air at speeds ranging from 1...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150500/dynamics-of-heterotrophic-bacterial-assemblages-within-synechococcus-cultures
#4
Qiang Zheng, Yu Wang, Rui Xie, Andrew S Lang, Yanting Liu, Jiayao Lu, Xiaodong Zhang, Jun Sun, Curtis A Suttle, Nianzhi Jiao
Interactions between photoautotrophic and heterotrophic microorganisms are central to the marine microbial ecosystem. Lab cultures of one of the dominant marine photoautotrophs, Synechococcus, have historically been difficult to render axenic, presumably because these bacteria depend upon other organisms to grow in these conditions. These tight associations between Synechococcus and heterotrophic bacteria represent a good, relevant system to study interspecies interactions. Ten individual Synechococcus strains, isolated from eutrophic and oligotrophic waters, were chosen for investigation...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29150346/aerodynamic-study-of-time-trial-helmets-in-cycling-racing-using-cfd-analysis
#5
F Beaumont, R Taiar, G Polidori, H Trenchard, F Grappe
The aerodynamic drag of three different time-trial cycling helmets was analyzed numerically for two different cyclist head positions. Computational Fluid Dynamics (CFD) methods were used to investigate the detailed airflow patterns around the cyclist for a constant velocity of 15 m/s without wind. The CFD simulations have focused on the aerodynamic drag effects in terms of wall shear stress maps and pressure coefficient distributions on the cyclist/helmet system. For a given head position, the helmet shape, by itself, obtained a weak effect on a cyclist's aerodynamic performance (<1...
November 8, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29150083/ct-imaging-features-of-symptomatic-and-asymptomatic-floating-aortic-thrombus
#6
E Klang, A Kerpel, S Soffer, M Zlotnik, O Shimon, U Rimon, E Konen, M M Amitai
AIM: To present the computed tomography (CT) imaging features of floating aortic thrombus with emphasis on clinical and radiographic predictors for systemic shower emboli. MATERIALS AND METHODS: A retrospective computerised search for patients with protruding thoracic aortic thrombus on CT was conducted. Clinical and demographic characteristics were retrieved from medical files. Patients were divided into two groups: symptomatic and asymptomatic, based on the presence or absence of documented systemic emboli at the time of diagnosis or during follow-up...
November 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29149699/tetrahymena-cilia-cap-is-built-in-a-multi-step-process-a-study-by-atomic-force-microscopy
#7
Cecília Seixas, João Gonçalves, Luís Viseu Melo, Helena Soares
Cilia are complex and dynamic organelles that have motility and sensory functions. Defects in cilia biogenesis and function are at the origin of human ciliopathies. In motile cilia, a basal body organizes the axoneme composed of nine microtubule doublets surrounding a central pair of singlet microtubules. The distal ends of axonemal microtubules are attached to the membrane by microtubule-capping structures. Little is known about the early steps of cilium assembly. Although cilia grow and resorb from their distal tips, it remains poorly understood where and when the components of the caps are first assembled...
October 20, 2017: Protist
https://www.readbyqxmd.com/read/29149637/antiviral-potential-of-natural-compounds-against-influenza-virus-hemagglutinin
#8
S Kannan, P Kolandaivel
Influenza virus of different subtypes H1N1, H2N2, H3N2 and H5N1 cause many human pandemic deaths and threatening the people worldwide. The Hemagglutinin (HA) protein mediates viral attachment to host receptors act as an attractive target. The sixteen natural compounds have been chosen to target the HA protein. Molecular docking studies have been performed to find binding affinity of the compounds. Out of the sixteen, three compounds CI, CII and CIII found to posses a higher binding affinity. The molecular dynamics (MD) simulation has been performed to study the structural, dynamical properties for the nine different complexes CI, CII, CIII bound with H1, H2, H3 proteins and the results were compared...
November 4, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29149620/the-dopamine-d4-receptor-gene-birth-weight-maternal-depression-maternal-attention-and-the-prediction-of-disorganized-attachment-at-36-months-of-age-a-prospective-gene%C3%A3-environment-analysis
#9
Justin Graffi, Ellen Moss, Alexia Jolicoeur-Martineau, Gal Moss, Vanessa Lecompte, Katherine Pascuzzo, Vanessa Babineau, Cathryn Gordon-Green, Viara R Mileva-Seitz, Klaus Minde, Roberto Sassi, Meir Steiner, James L Kennedy, Helene Gaudreau, Robert Levitan, Michael J Meaney, Ashley Wazana
BACKGROUND: Efforts to understand the developmental pathways for disorganized attachment reflect the importance of disorganized attachment on the prediction of future psychopathology. The inconsistent findings on the prediction of disorganized attachment from the dopamine D4 receptor (DRD4) gene, birth weight, and maternal depression as well as the evidence supporting the contribution of early maternal care, suggest the importance of exploring a gene by environment model. METHODS: Our sample is from the Maternal Adversity, Vulnerability, and Neurodevelopment project; consisting of 655 mother-child dyads...
November 14, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/29149539/dynamic-cross-exchange-in-halophosphonium-species-first-direct-observation-of-stereochemical-inversion-in-the-course-of-an-sn2-process
#10
Kirill Nikitin, Elizabeth V Jennings, Sulaiman Al Sulaimi, Yannick Ortin, Declan G Gilheany
The complex fluxional interconversions between, otherwise very similar, phosphonium bromides and chlorides R3PX+X- (R = Alk, Ar, X = Cl or Br) was studied by NMR techniques. Their energy barriers are typically ca. 11 kcal/mol but rise rapidly as bulky groups are attached to phosphorus, revealing the importance of steric factors. In contrast, electronic effects, as measured by Hammett analysis, are modest (rho 1.46) but still clearly indicate negative charge flow towards phosphorus in the transition state. Most significantly, detailed analysis of the exchange pathways unequivocally, and for the first time in any such process, shows that nucleophilic attack of the nucleophilic anion on the tetrahedral centre results in inversion of configuration...
November 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29149452/contextual-and-individual-determinants-of-periodontal-disease-multilevel-analysis-based-on-andersen-s-model
#11
Maria I B Valente, Mario V Vettore
AIM: To investigate the relationship of contextual and individual factors with periodontal disease in dentate adults and older people using the Andersen's behavioural model. METHODS: Secondary individual data from 6011 adults and 2369 older people from the Brazilian Oral Health Survey (2010) were combined with contextual data for 27 cities. Attachment loss (AL) categories for each sextant were coded and summed to obtain the periodontal disease measure. The association of predisposing, enabling and need characteristics at city and individual level with periodontal disease was assessed using an adapted version of the Andersen's behavioural model...
November 17, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29148837/prostitution-stigma-and-its-effect-on-the-working-conditions-personal-lives-and-health-of-sex-workers
#12
Cecilia Benoit, S Mikael Jansson, Michaela Smith, Jackson Flagg
Researchers have shown that stigma is a fundamental determinant of behavior, well-being, and health for many marginalized groups, but sex workers are notably absent from their analyses. This article aims to fill the empirical research gap on sex workers by reviewing the mounting evidence of stigmatization attached to sex workers' occupation, often referred to as "prostitution" or "whore" stigma. We give special attention to its negative effect on the working conditions, personal lives, and health of sex workers...
November 17, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29148782/effect-of-side-chain-branching-on-enhancement-of-ionic-conductivity-and-capacity-retention-of-copolymer-electrolyte-membrane
#13
Guopeng Fu, Thein Kyu
Low current drain driven by the low ionic conductivity of solid polymer electrolyte is one of the major obstacles of solid state battery. In an effort to improve the ionic conductivity, polyethylene glycol diacrylate (PEGDA) and monofunctional polyethylene glycol methyl ether acrylate (PEGMEA) were copolymerized via photopolymerization to afford PEGDA network with dangling PEGMEA side chains. By attaching PEGMEA side branches to the PEGDA network backbone, the glass transition temperature (Tg) was found to decrease, which may be controlled by varying relative amounts of PEGMEA and PEGDA...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29148737/site-specific-one-to-one-click-coupling-of-single-proteins-to-individual-carbon-nanotubes-a-single-molecule-approach
#14
Mark Freeley, Harley Worthy, Rochelle Ahmed, Ben Bowen, Daniel Watkins, John Emyr Macdonald, Ming Zheng, Darran Dafydd Jones, Matteo Palma
We report the site-specific coupling of single proteins to individual carbon nanotubes (CNTs) in solution and with single-molecule control. Using an orthogonal Click reaction, Green Fluorescent Protein (GFP) was engineered to contain a genetically encoded azide group and then bound to CNT ends in different configurations: in close proximity or at longer distances from the GFP's functional centre. Atomic force microscopy and fluorescence analysis in solution and on surfaces at the single-protein level confirmed the importance of bioengineering optimal protein attachment sites to achieve direct protein-nanotube communication and bridging...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29148722/acoustic-wave-driven-functionalized-particles-for-aptamer-based-target-biomolecule-separation
#15
Raheel Ahmad, Ghulam Destgeer, Muhammad Afzal, Jinsoo Park, Husnain Ahmed, Jin Ho Jung, Kwangseok Park, Tae-Sung Yoon, Hyung Jin Sung
We developed a hybrid microfluidic device that utilized acoustic waves to drive functionalized microparticles inside a continuous flow microchannel and to separate particle-conjugated target proteins from a complex fluid. The acoustofluidic device comprised of an interdigitated transducer (IDT) that produced high-frequency surface acoustic waves (SAW) in a polydimethylsiloxane (PDMS) microfluidic channel. The SAW interacted with the sample fluid flow inside the microchannel and deflected particles from their original streamlines to achieve separation...
November 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29148713/wireless-acoustic-surface-actuators-for-miniaturized-endoscopes
#16
Tian Qiu, Fabian Adams, Stefano Palagi, Kai Melde, Andrew G Mark, Ulrich Wetterauer, Arkadiusz Miernik, Peer Fischer
Endoscopy enables minimally invasive procedures in many medical fields, such as urology. However, current endoscopes are normally cable-driven, which limits their dexterity and makes them hard to miniaturize. Indeed current urological endoscopes have an outer diameter of about 3 mm and still only possess one bending degree of freedom. In this paper, we report a novel wireless actuation mechanism that increases the dexterity and that permits the miniaturization of a urological endoscope. The novel actuator consists of thin active surfaces that can be readily attached to any device and are wirelessly powered by ultrasound...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148699/controlling-ligand-spacing-on-surface-polyproline-based-fluorous-microarray-as-a-tool-in-spatial-specificity-analysis-and-inhibitor-development-for-carbohydrate-protein-interactions
#17
Tse-Hsueh Lin, Cin-Hao Lin, Ying-Jie Liu, Chun Yi Huang, Yen-Cheng Lin, Sheng-Kai Wang
Multivalent carbohydrate-protein interactions are essential for many biological processes. Convenient characterization for multivalent binding property of proteins will aid the development of molecules to manipulate these processes. We exploited the polyproline helix II (PPII) structure as molecular scaffolds to adjust the distances between glycan ligand attachment sites at 9, 18, and 27 Å on a peptide scaffold. Optimized fluorous groups were also introduced to the peptide scaffold for immobilization to the microarray surface through fluorous interaction to control the orientation of the helical scaffolds...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148591/statistical-modelling-of-sea-lice-count-data-from-salmon-farms-in-the-faroe-islands
#18
H Gislason
Fiskaaling regularly counts the number of sea lice in the attached development stages (chalimus, mobiles and adult) for the salmon farms in the Faroe Islands. A statistical model of the data is developed. In the model, the sea-lice infection is represented by the chalimus (or mobile) lice developing into adult lice and is used to simulate past and current levels of adult lice-including treatments-as well as to predict the adult sea lice level 1-2 months into the future. Time series of the chalimus and adult lice show cross-correlations that shift in time and grow in size with temperature...
November 17, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29148394/enteropathogenic-escherichia-coli-o80-h2-in-young-calves-with-diarrhea-belgium
#19
Damien Thiry, Marc Saulmont, Shino Takaki, Klara De Rauw, Jean-Noël Duprez, Atsushi Iguchi, Denis Piérard, Jacques G Mainil
Serogroup O80 was detected in 40% of 104 enteropathogenic Escherichia coli isolates from calves with diarrhea from 42 farms in Belgium during 2008‒2015. These isolates harbored the eae-ξ and fliCH2 genes, similar to the O80 attaching-effacing Shigatoxigenic E. coli isolates found in humans in France. This strain might be emerging.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29148129/development-of-functional-electrical-stimulation-rowing-the-rowstim-series
#20
Brian Andrews, Robin Gibbons, Garry Wheeler
Potentially, functional electrical stimulation (FES)-assisted exercise may have an important therapeutic role in reducing comorbidities associated with spinal cord injury (SCI). Here, we present an overview of these secondary life-threatening conditions, discuss the rationale behind the development of a hybrid exercise called FES rowing, and describe our experience in developing FES rowing technology. FES rowing and sculling are unique forms of adaptive rowing for those with SCI. The paralyzed leg musculature is activated by multiple channels of electrical pulses delivered via self-adhesive electrodes attached to the skin...
November 2017: Artificial Organs
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